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The variability of delivered dose of aerosols with the same respirable concentration but different size distributions. 可吸入浓度相同但粒径分布不同的气溶胶输送剂量的变异性。
Pub Date : 2002-06-01 DOI: 10.1093/ANNHYG/MEF046
N. Esmen, D. Johnson, G. Agron
The influences of aerosol size distribution and breath tidal volume on respirable dose estimates were examined for mouth breathing using the ACGIH/ISO/CEN criterion for respirable-equivalent aerosols. Actual tissue doses predicted from a set of pulmonary empirical deposition equations, the Heyder-Rudolf equations, were compared with deposition assumed to occur under the penetration-based respirable dust sampling criterion. Deposition estimate errors ranged from approximately 1/10- to 10-fold, with aerosol mass median aerodynamic equivalent diameter and geometric standard deviation as well as tidal volume each showing a substantial influence under appropriate conditions. These findings demonstrate that reliance on respirable aerosol sampling data obtained with devices performing on a penetration-based sampling criterion may lead to erroneous dose-response relationships in exposure standard development as well as exposure misclassification errors during epidemiological studies. A more reliable dose estimate would be obtained using devices with collection efficiency performance closely matching the alveolar deposition prediction curves of Heyder and Rudolf. We believe that if it is not currently required, the development of a deposition-based aerosol sampling methodology will soon be required for the determination and quantification of inhaled aerosol-induced adverse health effects.
采用ACGIH/ISO/CEN呼吸当量气溶胶标准,研究了气溶胶粒径分布和呼吸潮气量对口腔呼吸可吸入剂量估计的影响。根据一组肺经验沉积方程(Heyder-Rudolf方程)预测的实际组织剂量与基于穿透性呼吸性粉尘采样标准假设发生的沉积进行了比较。沉积估计误差约为1/10至10倍,在适当条件下,气溶胶质量中位数气动等效直径和几何标准偏差以及潮汐量均显示出重大影响。这些发现表明,依赖基于渗透取样标准的设备获得的可吸入性气溶胶取样数据可能导致暴露标准制定中的剂量-反应关系错误,以及流行病学研究中的暴露误分类错误。使用收集效率性能与Heyder和Rudolf的肺泡沉积预测曲线密切匹配的设备,可以获得更可靠的剂量估计。我们认为,即使目前不需要,也将很快需要开发一种基于沉积的气溶胶采样方法,以确定和量化吸入气溶胶引起的不利健康影响。
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引用次数: 16
Exposure to cooking fumes in restaurant kitchens in norway. 挪威餐馆厨房里的烹饪烟雾。
Pub Date : 2002-06-01 DOI: 10.1093/ANNHYG/MEF045
K. Svendsen, H. N. Jensen, Ingvill Sivertsen, A. Sjaastad
OBJECTIVESThe purpose of this study was to assess exposure to fat aerosols and aldehydes in kitchens and to study the variations in exposure between different types of kitchen.METHODSMeasurements were made in four hotel kitchens, two hamburger chain restaurants, 10 à la carte restaurants and three small local restaurants serving mostly fried food. The measurements were performed as personal measurements and each person carried two sampling devices connected to pumps. One pump was connected to a filter cassette with a 37 mm glassfibre filter and the other to a sampling device for aldehydes. The measurements were repeated on 3 days in each kitchen. Variables which could influence the level of exposure were recorded by the occupational hygienist.RESULTSThe level of fat aerosols varied between the different types of kitchen. The highest measured level of fat aerosol was 6.6 mg/m(3), in a small local restaurant. The arithmetic mean for all the kitchens was 0.62 mg/m(3). The highest level of the sum of the aldehydes was 186 micro g/m(3) (0.186 mg/m(3)), while the arithmetic mean was 69 micro g/m(3).CONCLUSIONSThe exposure to fat aerosols was modest, but could be up to 50% of the Norwegian threshold limit value (TLV) for nuisance dust (10 mg/m(3)). Fat aerosols from frying will, however, contain a mixture of heat- and water-treated fat from the meat which is being fried, hydrolysed vegetable fat and other degradation products, such as fatty acids, other organic acids and aldehydes. As a consequence of this, cooking fumes should be regarded as harmful to the lungs. The levels of formaldehyde, acetaldehyde and acrolein were well below the TLVs.
目的本研究的目的是评估厨房中脂肪气溶胶和醛的暴露情况,并研究不同类型厨房之间暴露情况的变化。方法对4家酒店厨房、2家汉堡连锁店、10家点菜餐厅和3家以油炸食品为主的当地小餐馆进行测量。测量以个人测量方式进行,每个人携带两个连接到泵的采样装置。一个泵连接到带有37毫米玻璃纤维过滤器的过滤盒,另一个泵连接到醛的采样装置。在每个厨房重复测量3天。职业卫生学家记录了可能影响暴露水平的变量。结果不同类型厨房的脂肪气溶胶含量存在差异。在当地一家小餐馆,测出的最高脂肪气溶胶浓度为6.6毫克/立方米。所有厨房的算术平均值为0.62 mg/m(3)。总醛含量最高为186微g/m(3) (0.186 mg/m(3)),算术平均值为69微g/m(3)。结论脂肪气溶胶的暴露是适度的,但可能高达挪威有害粉尘阈值(10 mg/m(3))的50%。然而,油炸过程中产生的脂肪气雾会包含一种混合物,其中包括被油炸的肉中经过热处理和水处理的脂肪、水解的植物脂肪和其他降解产物,如脂肪酸、其他有机酸和醛。因此,烹饪产生的油烟应该被认为对肺部有害。甲醛、乙醛和丙烯醛的含量远低于tlv。
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引用次数: 86
Partnership for sustainable healthy workplaces: Warner Lecture, British Occupational Hygiene Society, Sheffield 9 April 2002. 可持续健康工作场所的伙伴关系:2002年4月9日,英国职业卫生学会,谢菲尔德,华纳讲座。
Pub Date : 2002-06-01 DOI: 10.1093/ANNHYG/MEF061
R. Ennals
The paper sets out a fresh approach to healthy workplaces, laying foundations to meet the demands of the new millennium. Professionals such as occupational hygienists deal with issues at the heart of the economy and society, which are beginning to attract the attention of politicians. Old disciplinary barriers must be crossed and communication improved so that healthy work is accepted as a mainstream concern, integral to sustainable development. This presents challenges both to professionals and to those with responsibilities for policy. As a first step, we need to develop an understanding of how conclusions from research can inform responsible decision making. We will not be able to design and build perfectly safe environments, but real progress can be made in the field of 'workplace health defence', using available human, technical and financial resources. A vital ingredient is partnership in the workplace, involving social partners and professionals working in collaboration.
该文件提出了健康工作场所的新办法,为满足新千年的要求奠定了基础。职业卫生学家等专业人士处理经济和社会的核心问题,这些问题开始引起政治家的注意。必须跨越旧的学科障碍,改善沟通,使健康的工作被接受为一种主流关切,是可持续发展的组成部分。这对专业人员和负责政策的人员都提出了挑战。作为第一步,我们需要了解研究结论如何为负责任的决策提供信息。我们不可能设计和建造完全安全的环境,但可以利用现有的人力、技术和财政资源,在"工作场所健康防御"领域取得真正的进展。一个至关重要的因素是工作场所的伙伴关系,包括社会伙伴和专业人员的合作。
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引用次数: 11
Influence of push element geometry on the capture efficiency of push-pull ventilation systems in surface treatment tanks. 推元件几何形状对表面处理池推拉式通风系统捕集效率的影响。
Pub Date : 2002-06-01 DOI: 10.1093/ANNHYG/MEF048
F. Marzal, E. González, A. Miñana, A. Baeza
A full-scale installation which simulates a surface treatment tank provided with a push-pull ventilation system has been designed. This study examines the influence of the geometry of the push element on the capture efficiency of the system. It is observed that: (i) capture efficiency increases with the number of holes because of the continuous curtain formed, the size of the holes having no significant effect within the range studied (5-20 mm diameter); (ii) the push element is best supported on the tank wall so that no air from outside penetrates below the emitting jets because in this way the impact of the curtain on the tank occurs earlier and losses are less; (iii) the best results are obtained when the holes are directed downwards towards the tank surface at an angle of between 22 and 45 degrees.
设计了一个模拟具有推拉式通风系统的表面处理槽的全尺寸装置。本研究考察了推动元件的几何形状对系统捕获效率的影响。结果表明:(1)由于形成连续幕,捕集效率随孔数的增加而增加,孔的大小在研究范围内(5 ~ 20 mm直径)对捕集效率无显著影响;(ii)推动元件最好支撑在罐壁上,这样外部的空气就不会渗透到喷射器下面,因为这样幕帘对罐的冲击发生得更早,损失也更小;(iii)当孔以22至45度的角度向下指向罐面时,效果最好。
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引用次数: 18
Acute sensory irritation from exposure to isopropanol (2-propanol) at TLV in workers and controls: objective versus subjective effects. 工人和对照组在TLV暴露于异丙醇(2-丙醇)引起的急性感觉刺激:客观与主观影响
Pub Date : 2002-06-01 DOI: 10.1093/ANNHYG/MEF054
M. Smeets, C. Mauté, P. Dalton
OBJECTIVESPhlebotomists occupationally exposed to isopropanol (IPA) (2-propanol) and naïve controls (n = 12 per group) were exposed to the time-weighted average threshold limit value of 400 p.p.m. IPA for 4 h in an environmental chamber to investigate: (i) acute effects of sensory irritation using subjective health symptom reports and objective, physiological end-points; and (ii) differences in measured effects in relation to exposure history.METHODSBefore, during and after exposure subjects gave self-reports of health complaints. During exposure subjects rated the intensity of the odor, sensory irritation and annoyance. Objective end-points of ocular hyperemia, nasal congestion, nasal secretion and respiration were obtained at various times before, during and after exposure. Results were compared with exposure to phenylethyl alcohol (PEA), a negative control for irritation, and to clean air (CA), a negative control for odor and irritation, using a within-subjects design.RESULTSSignificantly higher intensity ratings of odor, irritation and annoyance were reported during the exposure to IPA, when compared with exposure to CA or PEA. Nevertheless, the overall level of reported sensory irritation to IPA was low and perceived as 'weak' on average. Health symptom ratings were not significantly elevated for IPA as compared with PEA or CA exposure. The only physiological end-point that showed a change exclusively in the IPA condition was respiration frequency: relative to baseline, respiration frequency increased in response to IPA in both groups. No differences were encountered between the occupationally exposed and the control groups.CONCLUSIONSThe increase in respiration frequency in response to IPA may reflect either a reflexive change due to sensory irritation (an autonomic event) or a voluntary change in breathing in response to perception of an unpleasant, solvent-like odor (a physiological event caused by cognitive mediation). Our findings on objective end-points, including nasal and ocular sensory irritation, did not confirm subjective irritation reports. Irritation reports and odor intensity decreased, rather than increased, over time, lending credence to the cognitive argument and suggesting that the elevated subjective responses to IPA may be mediated by responses to its odor.
目的:将职业暴露于异丙醇(IPA)(2-丙醇)和naïve对照组(每组n = 12)在环境室中暴露于400ppm IPA的时间加权平均阈限值4小时,以调查:(i)使用主观健康症状报告和客观生理终点的感觉刺激的急性效应;(ii)与暴露史相关的测量效应差异。方法受试者在暴露前、暴露中、暴露后分别自我报告健康状况。在暴露期间,受试者对气味、感官刺激和烦恼的强度进行评级。观察暴露前后不同时间眼充血、鼻塞、鼻分泌物和呼吸的终点。使用受试者内设计,将结果与暴露于苯乙醇(PEA)(刺激阴性对照)和清洁空气(CA)(气味和刺激阴性对照)进行比较。结果与暴露于CA或PEA相比,暴露于IPA期间报告的气味,刺激和烦恼的强度等级显着更高。然而,报告的对IPA的感官刺激的总体水平很低,平均感觉为“弱”。与PEA或CA暴露相比,IPA暴露的健康症状评分没有显著升高。在IPA条件下唯一显示变化的生理终点是呼吸频率:相对于基线,两组的呼吸频率均因IPA而增加。在职业暴露组和对照组之间没有发现差异。结论:IPA引起的呼吸频率增加可能反映了由于感觉刺激引起的反射性变化(一种自主事件),也可能反映了由于感知到令人不快的溶剂样气味而引起的自主呼吸变化(一种由认知介导引起的生理事件)。我们对客观终点的研究结果,包括鼻和眼感觉刺激,并没有证实主观刺激报告。随着时间的推移,刺激报告和气味强度减少而不是增加,这为认知论证提供了证据,并表明对IPA的主观反应升高可能是由对其气味的反应介导的。
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引用次数: 36
A critique of Bayesian methods for retrospective exposure assessment. 回顾性暴露评估贝叶斯方法的批判。
Pub Date : 2002-06-01 DOI: 10.1093/ANNHYG/MEF058
I. Burstyn, H. Kromhout
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引用次数: 22
Measuring the emission rate of an aerosol source placed in a ventilated room using a tracer gas: influence of particle wall deposition. 使用示踪气体测量放置在通风室内的气溶胶源的排放率:粒子壁沉积的影响。
Pub Date : 2002-04-01 DOI: 10.1093/ANNHYG/MEF031
D. Bémer, M. Lecler, R. Régnier, G. Hecht, J. Gerber
A method to measure the emission rate of an airborne pollutant source using a tracer gas was tested in the case of an aerosol source. The influence of particle deposition on the walls of a test room of 72 m3 was studied. The deposition rate of an aerosol of MgCl2 was determined by means of two methods: one based on measuring the aerosol concentration decay inside the ventilated room, the other based on calculation of the material mass balance. The concentration decay was monitored by optical counting and the aerosol mass concentration determined by means of sampling on a filter and analysis of the mass deposited by atomic absorption spectrometry. Four series of measurements were carried out. The curve giving the deposition rate according to the particle aerodynamic diameter (d(ae)) was established and shows deposition rates higher than those predicted using the model of Corner. The decay method gives the best results. The study carried out has shown that the phenomenon of deposition has little effect on the measurement of the aerosol source emission rate using a tracer gas for particles of aerodynamic diameter < 5 microm (underestimation < 25%). For particles of a greater diameter, wall deposition is an extremely limiting factor for the method, the influence of which can, however, be limited by using a test booth of small volume and keeping the sampling duration as short as possible.
在气溶胶源的情况下,测试了使用示踪气体测量空气传播污染源排放率的方法。研究了颗粒沉积对72 m3试验室壁面的影响。采用两种方法测定MgCl2气溶胶的沉积速率:一种是通过测量通风室内气溶胶浓度衰减,另一种是通过计算物质质量平衡。用光学计数法监测浓度衰减,用滤光片取样和原子吸收光谱法测定气溶胶质量浓度。进行了四个系列的测量。根据颗粒气动直径(d(ae))建立了沉积速率曲线,表明沉积速率高于Corner模型预测的沉积速率。衰减法给出了最好的结果。所进行的研究表明,对于气动直径< 5微米的颗粒,使用示踪气体测量气溶胶源排放率时,沉积现象几乎没有影响(低估< 25%)。对于较大直径的颗粒,壁沉积是该方法的一个极具限制性的因素,然而,可以通过使用小体积的测试室和尽可能短的采样时间来限制其影响。
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引用次数: 12
Respirable crystalline silica dust exposure during concrete finishing (grinding) using hand-held grinders in the construction industry. 在建筑行业使用手持式研磨机进行混凝土精加工(研磨)时,可吸入的结晶二氧化硅粉尘暴露。
Pub Date : 2002-04-01 DOI: 10.1093/ANNHYG/MEF043
F. Akbar-khanzadeh, R. L. Brillhart
Studies reporting the findings of exposure to crystalline silica dust during concrete finishing in construction settings are scarce due to the dynamic nature of the activity and the existence of many confounding factors. This study was initiated to explore the issue. A total of 49 personal respirable dust samples were collected during concrete finishing while workers used hand-held grinders. Only 15 (31%) of the grinders were equipped with local exhaust ventilation (LEV) systems. The confounding factors (e.g. wind velocity, wind direction, relative humidity and ambient temperature) were determined. To make the sampling task-specific, air sampling was activated only during actual grinding. Task-specific sampling times during each work shift ranged from 10 to 200 min. The concentration of total respirable particulate ranged from 0.34 to 81 mg/m3, with a mean +/- SD of 18.6 +/- 20.4 mg/m3, and the concentration of crystalline silica in the samples ranged from 0.02 to 7.1 mg/m3, with a mean +/- SD of 1.16 +/- 1.36 mg/m3. LEV on the grinders reduced the silica dust level significantly (P < 0.01) compared to grinders without LEV. Increased wind velocity also reduced the silica dust concentration significantly (P < 0.03). Working upwind reduced the exposure to silica dust compared to working downwind, but the difference was not statistically significant. The time-weighted average concentration of silica dust in 69% of the samples exceeded the current recommended threshold limit value of 0.05 mg/m3, indicating a strong need to devise methods for controlling workers' exposure to crystalline silica dust during concrete finishing activities.
由于活动的动态性和许多混杂因素的存在,在施工环境中暴露于结晶二氧化硅粉尘的研究很少。这项研究是为了探讨这个问题。在工人使用手持式研磨机进行混凝土抛光时,共收集了49份个人可呼吸性粉尘样本。只有15台(31%)研磨机配备了局部排气通风(LEV)系统。确定了干扰因素(如风速、风向、相对湿度和环境温度)。为了使采样任务特定,空气采样仅在实际研磨期间激活。每个班次的特定任务采样时间为10至200分钟。总可吸入颗粒物浓度范围为0.34至81 mg/m3,平均+/- SD为18.6 +/- 20.4 mg/m3,样品中结晶二氧化硅浓度范围为0.02至7.1 mg/m3,平均+/- SD为1.16 +/- 1.36 mg/m3。与未施加LEV的磨机相比,施加LEV可显著降低硅尘水平(P < 0.01)。风速的增加也显著降低了硅尘浓度(P < 0.03)。与下风工作相比,逆风工作减少了二氧化硅粉尘的暴露,但差异无统计学意义。69%的样品中二氧化硅粉尘的时间加权平均浓度超过了目前建议的0.05 mg/m3的阈值,这表明迫切需要设计方法来控制工人在混凝土整理活动中对结晶二氧化硅粉尘的暴露。
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引用次数: 63
Developments in the RICE asbestos fibre counting scheme, 1992-2000. Regular Interlaboratory Counting Exchanges. 1992-2000年稻米石棉纤维计数计划的发展。定期实验室间计数交换。
Pub Date : 2002-04-01 DOI: 10.1093/ANNHYG/MEF033
P. Brown, Alan D. Jones, B. Miller
The UK's Regular Interlaboratory Counting Exchanges (RICE) scheme provides proficiency testing for laboratories counting asbestos fibres by phase contrast optical microscopy, as in the method for measurement of airborne fibre concentrations. From 1984 to 1992, the scheme used circulations of industrial samples containing mostly chrysotile, and reference values were obtained from fibre counts by automated image analysis. In 1992, lower density (< 100 fibres/mm2) samples from asbestos clearance operations were added and the new reference values were medians of the laboratories' determinations. In extensive data from 28 recent rounds of sample exchanges, the new reference values are shown to be more reliable than the old. Average counting levels have changed, with different trends according to fibre density. In low density samples, after initial increases, the levels appear to have stabilized. Counting levels on the higher density samples show a continuing trend of approximately 0.5% decrease per round. Widening the density range may have reduced the influence of counters' preconceptions of what values are expected and so their counts on the reference samples may now better reflect their routine counting. The implications of these findings and of other new developments, such as expected new counting rules, are discussed.
英国的常规实验室间计数交换(RICE)计划为通过相衬光学显微镜计数石棉纤维的实验室提供熟练程度测试,就像测量空气中纤维浓度的方法一样。从1984年到1992年,该方案使用了主要含有温石棉的工业样品的循环,并通过自动图像分析从纤维计数中获得参考值。1992年,从石棉清除行动中增加了较低密度(< 100纤维/平方毫米)的样品,新的参考值是实验室测定的中位数。最近28轮抽样交换的大量数据表明,新的参考值比旧的参考值更可靠。平均计数水平已经改变,根据纤维密度有不同的趋势。在低密度样品中,在最初的增加之后,水平似乎已经稳定下来。高密度样本上的计数水平显示出每轮下降约0.5%的持续趋势。扩大密度范围可能减少了计数员对预期值的先入为主的观念的影响,因此他们对参考样本的计数现在可以更好地反映他们的常规计数。讨论了这些发现和其他新发展的含义,例如预期的新计数规则。
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引用次数: 7
Development of a systematic observation protocol of physical exposure of the back: a preliminary study. 制定背部物理暴露的系统观察方案:初步研究。
Pub Date : 2002-04-01 DOI: 10.1093/ANNHYG/MEF042
M. Tousignant, G. Tougas, M. Rossignol, L. Goulet
OBJECTIVEAt present there is no systematic observation protocol for the assessment of the multi-factorial aspects of physical exposure related to the back used within the constraints of occupational epidemiological research. In this context, a new preliminary systematic observation protocol is proposed to assess exposure to physical loading of the back using nine categories of physical risk factors: the SOPE back protocol. The objective of this study was to investigate whether the new protocol can correctly identify the level of exposure related to measured physical loading of the back.METHODSThe subjects of this closed cohort study were 451 manual workers at a natural gas distribution company. The assessment of exposure was made with the protocol using groups with different job titles. The workers were followed for a 2 yr period to establish the risk of a new occurrence of complete disability related to the back (NOCD back injury) in each job grouping.RESULTSBased on the median of the total scores derived from the protocol, two levels of exposure were identified (high and low).CONCLUSIONTaking into account the limitations of this study, the protocol in development may be a good tool to establish two levels of exposure to physical loading of the back in large epidemiological studies of occupational low back pain. Further research is needed to replicate these results with larger samples and to test the reliability and predictive validity of the protocol.
目的目前在职业流行病学研究的限制下,没有系统的评价背部相关身体暴露多因素的观察方案。在此背景下,提出了一种新的初步系统观察方案,使用九类物理风险因素来评估背部物理负荷暴露:SOPE背部方案。本研究的目的是调查新方案是否能正确识别与背部物理负荷测量相关的暴露水平。方法对某天然气配送公司451名体力劳动者进行封闭式队列研究。根据该方案,使用不同职称的小组进行暴露评估。对工人进行为期2年的随访,以确定每个工作分组中与背部相关的完全残疾(NOCD背部损伤)新发生的风险。结果根据方案得出的总分的中位数,确定了两个暴露水平(高和低)。考虑到本研究的局限性,正在制定的方案可能是在职业性腰痛的大型流行病学研究中建立两个水平的背部物理负荷暴露的良好工具。需要进一步的研究来用更大的样本复制这些结果,并测试该方案的可靠性和预测有效性。
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引用次数: 6
期刊
The Annals of occupational hygiene
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