Lancet Healthy Longevity最新文献

{"title":"The Lancet Healthy Longevity: looking to the future.","authors":"The Lancet Healthy Longevity","doi":"10.1016/j.lanhl.2026.100821","DOIUrl":"https://doi.org/10.1016/j.lanhl.2026.100821","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":" ","pages":"100821"},"PeriodicalIF":14.6,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thank you to The Lancet Healthy Longevity statistical and peer reviewers in 2025.","authors":"The Lancet Healthy Longevity Editors","doi":"10.1016/j.lanhl.2026.100818","DOIUrl":"https://doi.org/10.1016/j.lanhl.2026.100818","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":" ","pages":"100818"},"PeriodicalIF":14.6,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146047066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transgender ageing in Thailand: from visibility to recognition in healthy longevity.","authors":"Suchanan Chieowisaman, Krit Pongpirul","doi":"10.1016/j.lanhl.2025.100813","DOIUrl":"https://doi.org/10.1016/j.lanhl.2025.100813","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":" ","pages":"100813"},"PeriodicalIF":14.6,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining and addressing loneliness in older adults with cancer: an international Delphi consensus from the Multinational Association of Supportive Care in Cancer Geriatrics Study Group.","authors":"Enrique Soto-Perez-de-Celis, Kristen R Haase, Sriram Yennu, Etienne Brain, Chad Yixian Han, Jørn Herrstedt, Ayumu Matsuoka, Joana Marinho, Lewis Mustian, Sophie Pilleron, Imogen Ramsey, Christopher Steer, Matti Aapro","doi":"10.1016/j.lanhl.2025.100811","DOIUrl":"https://doi.org/10.1016/j.lanhl.2025.100811","url":null,"abstract":"<p><p>Loneliness is a growing public health concern among older adults (aged 65 and older) but remains understudied and under-recognised in geriatric oncology. This Health Policy paper presents survey-based Delphi consensus statements developed by a global panel of experts from the Multinational Association of Supportive Care in Cancer Geriatrics Study Group on the definition, assessment, and management of loneliness in older adults with cancer, to inform research and clinical practice. A consensus was reached on the definitions of loneliness, emphasising upon both emotional and social components, and including contextual factors such as life events and community structures. Multidisciplinary assessment using brief evaluation tools at the time of cancer diagnosis was highlighted. Community-based interventions such as support groups, home visits, and psychological counselling were prioritised over technology-driven approaches for future research. Outcomes considered the most relevant for research on loneliness included quality of life, treatment adherence, and survival. These statements could guide future clinical and research initiatives targeting loneliness in geriatric oncology.</p>","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":" ","pages":"100811"},"PeriodicalIF":14.6,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International trends and social disparities in pain of adults aged 50 years and older in 22 countries across Europe, Asia, and the Americas: a longitudinal population-based study.","authors":"Esteban Calvo, Jose T Medina, Hanna Grol-Prokopczyk, Katherine Keyes, Alvaro Castillo-Carniglia, Antonia Díaz-Valdés, Tamara Otzen, Robin Richardson, Silvia Martins","doi":"10.1016/j.lanhl.2025.100808","DOIUrl":"https://doi.org/10.1016/j.lanhl.2025.100808","url":null,"abstract":"<p><strong>Background: </strong>The experience of pain is highly prevalent among older adults worldwide. This study aimed to compare trends and social disparities in pain for middle aged and older adults (ie, those aged ≥50 years) across countries to help identify high-pain or high-disparity hotspots needing intervention, and low-pain or low-disparity locations or timepoints from which policy and practice lessons could be drawn.</p><p><strong>Methods: </strong>Country-specific pain trends were estimated using longitudinal logistic regressions on harmonised data for 212 904 adults aged older than 50 years observed repeatedly from 1998 to 2018 in 22 countries across three continents.</p><p><strong>Findings: </strong>Unadjusted pain prevalence was 43·21% (95% CI 43·10-43·33) across all countries and years pooled. Instrument-adjusted prevalence ranged from 26·70% (95% CI 25·52-27·88; Netherlands, 2006) to 59·20% (58·02-60·38; France, 2016). Over the decade 2006-16, when most countries were observed, prevalence substantially increased in 15 countries (12·01 percentage points), decreased in China (6·60 percentage points), and remained steady in six countries. Prevalence was higher among women, those with less education (ie, completed less than high school), and older respondents (those aged >60 years), though disparities varied substantially across countries. Disparities widened over time in some countries (eg, Spain), but remained stable, declined, or reversed in others (eg, Sweden). In 2016, Denmark had the lowest overall pain disparity index, while South Korea had the highest.</p><p><strong>Interpretation: </strong>There was a substantial increase in pain prevalence among middle aged and older adults in most countries studied. Cross-country, temporal, and sociodemographic variation indicates pain should be treated as a population public health issue.</p><p><strong>Funding: </strong>Agencia Nacional de Investigación y Desarrollo, National Institute on Aging.</p>","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":" ","pages":"100808"},"PeriodicalIF":14.6,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty and prognosis of biomarker-confirmed Alzheimer’s disease: a Swedish, register-based, retrospective cohort study","authors":"Xin Xia PhD ,&nbsp;Prof Maria Eriksdotter MD ,&nbsp;Prof Henrik Zetterberg MD ,&nbsp;Prof Silke Kern MD ,&nbsp;Tobias Skillbäck PhD ,&nbsp;Marco Toccaceli Blasi MD ,&nbsp;Prof Bengt Winblad MD ,&nbsp;Jonathan K L Mak PhD ,&nbsp;Alice Margherita Ornago MD ,&nbsp;Elena Pinardi MD ,&nbsp;Prof Román Romero Ortuño PhD ,&nbsp;Prof Linus Jönsson MD","doi":"10.1016/j.lanhl.2025.100797","DOIUrl":"10.1016/j.lanhl.2025.100797","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to examine the value of frailty status (defined by the frailty index) in informing the prognosis of people living with Alzheimer’s disease.</div></div><div><h3>Methods</h3><div>In this retrospective cohort study, we used the Swedish Registry for Cognitive/Dementia Disorders linked to other Swedish health-care registers to collect data from May 1, 2007, to Dec 31, 2020. We included people with mild cognitive impairment or Alzheimer’s disease dementia, both with cerebrospinal fluid (CSF) biomarkers supporting Alzheimer’s pathology. We excluded people living in an institution or those who did not have at least one Mini-Mental State Examination (MMSE). We constructed a 41-item frailty index, incorporating diseases, symptoms, polypharmacy, nutritional status, and care dependency. Individuals with frailty index scores of 0·25 or above were considered frail. The associations between frailty and MMSE trajectories, subsequent institutionalisation, and mortality were evaluated by jointly modelling longitudinal and survival data. We also examined whether frailty could modify the associations between CSF amyloid β₄₂, phosphorylated tau₁₈₁, and total tau and cognitive decline.</div></div><div><h3>Findings</h3><div>The study included 7251 individuals (mean age 72·7 years, 4271 [58·9%] females, 2980 [41·1%] males). Frailty was associated with a 0·723-point (95% CI 0·250–1·196) lower baseline MMSE but not with the rate of MMSE decline. Frailty was associated with a hazard ratio of 1·91 (1·43–2·54) for institutionalisation and 2·41 (1·73–3·33) for mortality. Individuals living with frailty had a 1·3-year (0·9–1·7) shorter lifespan and a 1·0-year (0·8–1·3) shorter non-institutionalised lifespan. Associations between CSF biomarkers and MMSE trajectories did not differ by frailty status.</div></div><div><h3>Interpretation</h3><div>Frailty, measured by the frailty index, predicted institutionalisation and mortality in people with Alzheimer’s disease, but its absence of association with cognitive decline suggests neurodegeneration as the primary driver.</div></div><div><h3>Funding</h3><div>Innovative Health Initiative Joint Undertaking and Vinnova.</div></div>","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"6 12","pages":"Article 100797"},"PeriodicalIF":14.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical effectiveness of music interventions for dementia and depression in older people (MIDDEL): a multinational, cluster-randomised controlled trial","authors":"Vigdis Sveinsdottir PhD ,&nbsp;Jörg Assmus PhD ,&nbsp;Prof Justine Schneider PhD ,&nbsp;Prof Felicity A Baker PhD ,&nbsp;Burçin Uçaner PhD ,&nbsp;Prof Gunter Kreutz PhD ,&nbsp;Monika Geretsegger PhD ,&nbsp;Naomi Rasing PhD ,&nbsp;Jodie Bloska MA ,&nbsp;Phoebe A Stretton-Smith MMusThrp ,&nbsp;Young-Eun C Lee PhD ,&nbsp;Jo Dugstad Wake PhD ,&nbsp;Prof Helen Odell-Miller PhD ,&nbsp;Jeanette Tamplin PhD ,&nbsp;Annemieke C Vink PhD ,&nbsp;Joanne Ablewhite PhD ,&nbsp;Johanna Neuser MSc ,&nbsp;Ulrike Frischen Dr rer Nat ,&nbsp;Prof Antje Timmer PhD ,&nbsp;Prof Thomas Wosch PhD ,&nbsp;Prof Christian Gold PhD","doi":"10.1016/j.lanhl.2025.100783","DOIUrl":"10.1016/j.lanhl.2025.100783","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Dementia and depression are among the leading causes of global disease burden. Effective and scalable interventions are needed to address the effect of these conditions, and music interventions are a promising non-pharmacological approach. The aim of this study was to determine the effectiveness of music interventions on depressive symptoms among care home residents with dementia in Australia, Germany, the Netherlands, Norway, Türkiye, and the UK.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Music Interventions for Dementia and Depression in Elderly care was a large, multinational, cluster-randomised controlled trial with a 2 × 2 factorial design to examine the effects of group music therapy, recreational choir singing, or both compared with standard care. The trial was done in 86 care home units across Australia, Germany, the Netherlands, Norway, Türkiye, and the UK. Care home units were required to host at least ten residents who met the inclusion criteria. Participants were required to be aged 65 years or older; a full-time resident in a participating care home unit; have dementia as indicated by a Clinical Dementia Rating score of 0·5–3 and a Mini-Mental State Examination score of 26 or less; have mild depressive symptoms as indicated by a Montgomery–Åsberg Depression Rating Scale (MADRS) score of at least 8; and a clinical diagnosis of dementia. Care home units with residents with dementia and depressive symptoms were randomly assigned (1:1:1:1; block randomisation stratified by site, using a computer-generated list) to group music therapy, recreational choir singing, a combination of these strategies, or standard care. The primary outcome was MADRS assessed at 6 months in the intention-to-treat population, which included all participants with available data. Assessors were masked but care staff, intervention providers, and residents were not masked due to the nature of the intervention. Intervention effects were analysed with ANCOVA for the total sample and per country. The trial was registered at &lt;span&gt;&lt;span&gt;ClinicalTrials.gov&lt;/span&gt;&lt;svg&gt;&lt;path&gt;&lt;/path&gt;&lt;/svg&gt;&lt;/span&gt;, &lt;span&gt;&lt;span&gt;NCT03496675&lt;/span&gt;&lt;svg&gt;&lt;path&gt;&lt;/path&gt;&lt;/svg&gt;&lt;/span&gt;, and is completed.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Findings&lt;/h3&gt;&lt;div&gt;Between July 18, 2018, and Feb 1, 2023, 86 care home units with 1021 residents were enrolled and randomly assigned to one of the four groups. 22 care home units with 258 residents were randomly assigned to group music therapy, 22 care home units with 281 residents were allocated to recreational choir singing, 21 care home units with 244 residents were assigned to a combination of both group music therapy and recreational choir singing, and 21 care home units with 238 residents were assigned to standard care. The mean age of residents was 85·6 years (SD 7·4); most residents (747 [73·2%]) were female and 274 (26·8%) were male. Intention-to-treat analysis of 751 residents with data at 6 months showed no significant effect on MADRS scores of eit","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"6 12","pages":"Article 100783"},"PeriodicalIF":14.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145744907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopause hormone therapy and risk of mild cognitive impairment or dementia: a systematic review and meta-analysis","authors":"Melissa Melville MSci ,&nbsp;Lexi He MSci ,&nbsp;Roopal Desai DClinPsy PhD ,&nbsp;Primrose Nyamayaro PhD ,&nbsp;Prof Chris Fox MD ,&nbsp;Kavita U Kothari MPH ,&nbsp;Patrick Condron GradDip ,&nbsp;Miao Miao PhD ,&nbsp;Prof Martha Hickey PhD ,&nbsp;Prof Aimee Spector DClinPsy PhD","doi":"10.1016/j.lanhl.2025.100803","DOIUrl":"10.1016/j.lanhl.2025.100803","url":null,"abstract":"<div><h3>Background</h3><div>Globally, dementia disproportionately affects women. Changes in circulating sex steroids over the menopause transition might contribute to this sex difference. Menopause hormone therapy (MHT) is recommended by the UK National Institute for Health and Care Excellence to manage menopausal symptoms, but whether MHT use affects dementia risk and how this association might vary by age at menopause is unclear. We aimed to assess whether MHT (<em>vs</em> no MHT) affects the risk of mild cognitive impairment or dementia in peri-menopausal or post-menopausal women, including those with premature ovarian insufficiency or early menopause (with normal cognition or mild cognitive impairment), and whether MHT type, duration, or age at initiation influence this risk.</div></div><div><h3>Methods</h3><div>We systematically searched MEDLINE via OVID, Embase via Elsevier, Cochrane via OVID, and PsycINFO via OVID for systematic reviews published between Jan 1, 2000, and Dec 19, 2024. As no existing review met our quality or scope criteria, we proceeded to conduct a systematic review and meta-analysis of primary studies published from Jan 1, 2000, to Oct 20, 2025. Eligible primary studies included randomised controlled trials (RCTs), non-randomised intervention studies, and prospective observational studies examining the association between MHT—including oestrogen-only MHT, combined MHT, testosterone, and tibolone—and incident mild cognitive impairment or dementia. Two reviewers independently screened studies, extracted data, and assessed risk of bias using RoB 2 and ROBINS-E, with certainty of evidence rated using GRADE. Meta-analyses pooled relative risk estimates in a random-effects model. The protocol was preregistered on PROSPERO (CRD42025639384).</div></div><div><h3>Findings</h3><div>Of 5914 records, ten studies (one RCT and nine observational studies) with a total of 1 016 055 participants were included. Certainty of evidence ranged from moderate to very low. No included studies examined testosterone or use in premature ovarian insufficiency. No significant association was found between MHT use and risk of mild cognitive impairment or dementia. Subgroup analyses by timing, duration, and type of MHT showed no significant effects.</div></div><div><h3>Interpretation</h3><div>This review found no evidence that MHT use either increases or decreases the risk of dementia in post-menopausal women. This reinforces current clinical guidance, that MHT prescription should be based on other perceived benefits and risks and not for dementia prevention. High-quality, long-term studies are needed to clarify the role of MHT and dementia risk, particularly regarding formulation, dose, route, timing, and duration of treatment, with a focus on women with premature ovarian insufficiency, early menopause, or mild cognitive impairment.</div></div><div><h3>Funding</h3><div>The Public Health Agency of Canada.</div></div>","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"6 12","pages":"Article 100803"},"PeriodicalIF":14.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporality might matter in people with atrial fibrillation and heart failure","authors":"Laurent Fauchier ,&nbsp;Matthieu Nasarre ,&nbsp;Thibaud Lenormand","doi":"10.1016/j.lanhl.2025.100805","DOIUrl":"10.1016/j.lanhl.2025.100805","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"6 12","pages":"Article 100805"},"PeriodicalIF":14.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145764223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring what matters in ageing societies: integrating dying-well and living-well metrics for resilient health systems","authors":"Andreea Alexandra Piriu ,&nbsp;Aleksandra Torbica","doi":"10.1016/j.lanhl.2025.100799","DOIUrl":"10.1016/j.lanhl.2025.100799","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"6 12","pages":"Article 100799"},"PeriodicalIF":14.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145752229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}