Lancet Healthy Longevity最新文献

{"title":"Thank you to The Lancet Healthy Longevity statistical and peer reviewers in 2025","authors":"The Lancet Healthy Longevity Editors","doi":"10.1016/j.lanhl.2026.100818","DOIUrl":"10.1016/j.lanhl.2026.100818","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"7 1","pages":"Article 100818"},"PeriodicalIF":14.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146047066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A global gap in autonomy assessment among older adults: a COSMIN systematic review","authors":"Masoud Rahmati PhD ,&nbsp;Thomas Renou MSc ,&nbsp;Sibylle Del Duca MSc ,&nbsp;Houria El Ouazzani PhD ,&nbsp;Marie Anastasie Aim PhD ,&nbsp;Prof Lee Smith PhD ,&nbsp;Prof Dong Keon Yon PhD ,&nbsp;Prof Pascal Auquier PhD ,&nbsp;Prof Laurent Boyer PhD ,&nbsp;Karine Baumstarck PhD","doi":"10.1016/j.lanhl.2025.100814","DOIUrl":"10.1016/j.lanhl.2025.100814","url":null,"abstract":"<div><div>Autonomy is increasingly recognised as the basis of healthy ageing and person-centred care; however, it remains under-represented in clinical assessments and policy. We systematically reviewed patient-reported outcome measures and clinician-reported outcome measures of autonomy in adults aged 60 years and older (older adults), following the consensus-based standards for the selection of health measurement instruments (COSMIN) methodology (PROSPERO CRD42025640772). Across 116 studies involving 861 338 older adults in 42 countries, 50 instruments were evaluated for structural validity, reliability, internal consistency, cross-cultural validity, and responsiveness. High-quality evidence supported structural validity in 29 instruments, internal consistency in 33, and test–retest reliability in 17, whereas content validity and responsiveness were often insufficient. 14 instruments met the COSMIN category A criteria (ie, instruments with sufficient content validity and at least low-quality evidence for sufficient internal consistency, indicating that they are reliable and suitable for recommendation) and were recommended for research and clinical use. Substantial gaps remain, particularly in cross-cultural validity and responsiveness of the tested instruments, highlighting the need for internationally aligned, culturally robust, and co-created tools. Health authorities should adopt validated measures to assess autonomy, guide policy, and ensure equitable resource allocation.</div></div>","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"7 1","pages":"Article 100814"},"PeriodicalIF":14.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146195754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining and addressing loneliness in older adults with cancer: an international Delphi consensus from the Multinational Association of Supportive Care in Cancer Geriatrics Study Group","authors":"Enrique Soto-Perez-de-Celis PhD ,&nbsp;Kristen R Haase PhD ,&nbsp;Prof Sriram Yennu MD ,&nbsp;Etienne Brain PhD ,&nbsp;Chad Yixian Han PhD ,&nbsp;Prof Jørn Herrstedt MD ,&nbsp;Ayumu Matsuoka PhD ,&nbsp;Joana Marinho PhD ,&nbsp;Lewis Mustian BS ,&nbsp;Sophie Pilleron PhD ,&nbsp;Imogen Ramsey PhD ,&nbsp;Christopher Steer MD ,&nbsp;Prof Matti Aapro MD","doi":"10.1016/j.lanhl.2025.100811","DOIUrl":"10.1016/j.lanhl.2025.100811","url":null,"abstract":"<div><div>Loneliness is a growing public health concern among older adults (aged 65 and older) but remains understudied and under-recognised in geriatric oncology. This Health Policy paper presents survey-based Delphi consensus statements developed by a global panel of experts from the Multinational Association of Supportive Care in Cancer Geriatrics Study Group on the definition, assessment, and management of loneliness in older adults with cancer, to inform research and clinical practice. A consensus was reached on the definitions of loneliness, emphasising upon both emotional and social components, and including contextual factors such as life events and community structures. Multidisciplinary assessment using brief evaluation tools at the time of cancer diagnosis was highlighted. Community-based interventions such as support groups, home visits, and psychological counselling were prioritised over technology-driven approaches for future research. Outcomes considered the most relevant for research on loneliness included quality of life, treatment adherence, and survival. These statements could guide future clinical and research initiatives targeting loneliness in geriatric oncology.</div></div>","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"7 1","pages":"Article 100811"},"PeriodicalIF":14.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transgender ageing in Thailand: from visibility to recognition in healthy longevity","authors":"Suchanan Chieowisaman ,&nbsp;Krit Pongpirul","doi":"10.1016/j.lanhl.2025.100813","DOIUrl":"10.1016/j.lanhl.2025.100813","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"7 1","pages":"Article 100813"},"PeriodicalIF":14.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Lancet Healthy Longevity: looking to the future","authors":"The Lancet Healthy Longevity","doi":"10.1016/j.lanhl.2026.100821","DOIUrl":"10.1016/j.lanhl.2026.100821","url":null,"abstract":"","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"7 1","pages":"Article 100821"},"PeriodicalIF":14.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International trends and social disparities in pain of adults aged 50 years and older in 22 countries across Europe, Asia, and the Americas: a longitudinal population-based study","authors":"Prof Esteban Calvo PhD ,&nbsp;Jose T Medina MS ,&nbsp;Hanna Grol-Prokopczyk PhD ,&nbsp;Prof Katherine Keyes PhD ,&nbsp;Prof Alvaro Castillo-Carniglia PhD ,&nbsp;Antonia Díaz-Valdés PhD ,&nbsp;Tamara Otzen PhD ,&nbsp;Robin Richardson PhD ,&nbsp;Prof Silvia Martins PhD","doi":"10.1016/j.lanhl.2025.100808","DOIUrl":"10.1016/j.lanhl.2025.100808","url":null,"abstract":"<div><h3>Background</h3><div>The experience of pain is highly prevalent among older adults worldwide. This study aimed to compare trends and social disparities in pain for middle aged and older adults (ie, those aged ≥50 years) across countries to help identify high-pain or high-disparity hotspots needing intervention, and low-pain or low-disparity locations or timepoints from which policy and practice lessons could be drawn.</div></div><div><h3>Methods</h3><div>Country-specific pain trends were estimated using longitudinal logistic regressions on harmonised data for 212 904 adults aged older than 50 years observed repeatedly from 1998 to 2018 in 22 countries across three continents.</div></div><div><h3>Findings</h3><div>Unadjusted pain prevalence was 43·21% (95% CI 43·10–43·33) across all countries and years pooled. Instrument-adjusted prevalence ranged from 26·70% (95% CI 25·52–27·88; Netherlands, 2006) to 59·20% (58·02–60·38; France, 2016). Over the decade 2006–16, when most countries were observed, prevalence substantially increased in 15 countries (12·01 percentage points), decreased in China (6·60 percentage points), and remained steady in six countries. Prevalence was higher among women, those with less education (ie, completed less than high school), and older respondents (those aged &gt;60 years), though disparities varied substantially across countries. Disparities widened over time in some countries (eg, Spain), but remained stable, declined, or reversed in others (eg, Sweden). In 2016, Denmark had the lowest overall pain disparity index, while South Korea had the highest.</div></div><div><h3>Interpretation</h3><div>There was a substantial increase in pain prevalence among middle aged and older adults in most countries studied. Cross-country, temporal, and sociodemographic variation indicates pain should be treated as a population public health issue.</div></div><div><h3>Funding</h3><div>Agencia Nacional de Investigación y Desarrollo, National Institute on Aging.</div></div>","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"7 1","pages":"Article 100808"},"PeriodicalIF":14.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypofractionated split-course versus standard radiotherapy in frail older patients with head and neck squamous-cell carcinoma (ELAN-RT trial): a non-inferiority, multicentre, open-label, randomised controlled trial","authors":"Cécile Ortholan MD ,&nbsp;Anne Aupérin PhD ,&nbsp;Prof Yungan Tao MD ,&nbsp;Sophie Renard MD ,&nbsp;Yoann Pointreau MD ,&nbsp;Cédrik Lafond MD ,&nbsp;Guillaume Bera MD ,&nbsp;Pierre Boisselier MD ,&nbsp;Karen Benezery MD ,&nbsp;Séverine Racadot MD ,&nbsp;Prof Florence Huguet MD ,&nbsp;Marc Bollet MD ,&nbsp;Antoine Laurent Braccini MD ,&nbsp;Cédric Khoury MD ,&nbsp;Stéphane Jacquot MD ,&nbsp;Julie Villa MD ,&nbsp;Laurent Martin MD ,&nbsp;Alessia Di Rito MD ,&nbsp;Nadia Wiazzane MD ,&nbsp;Aurore Goineau MD ,&nbsp;Xu-Shan Sun MD","doi":"10.1016/j.lanhl.2025.100812","DOIUrl":"10.1016/j.lanhl.2025.100812","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;The standard treatment for older patients (aged ≥70 years) with localised, unresectable head and neck squamous-cell carcinoma is standard fractionated radiotherapy (SF-RT). However, its high toxicity and multiple fractions lead physicians to deliver tailored hypofractionated split-course radiotherapy (HSC-RT). The aim of the study was to compare these two radiotherapy methods in older patients.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;This non-inferiority, multicentre, open-label, randomised controlled trial was done in 30 treating centres (cancer centres, university and general hospitals, and private clinics) across France and Monaco. Patients aged 70 years or older, assessed as frail by geriatric evaluation, with stage II–IV head and neck squamous-cell carcinoma and in curative intent were randomly assigned (1:1) to receive either SF-RT (70 Gy, 35 fractions over 7 weeks) or HSC-RT (55 Gy, 20 fractions, two courses of 2 weeks with 2 weeks stop). Randomisation was done by minimisation, and physicians and patients were not masked to the treatment group. The primary endpoint was the proportion of patients alive with complete locoregional response at 6 months, analysed in all randomly assigned patients (intention-to-treat population). The non-inferiority margin was set at 16%. The study was sponsored by the Groupe d'Oncologie Radiothérapie Tête et Cou (GORTEC) and is registered with &lt;span&gt;&lt;span&gt;ClinicalTrials.gov&lt;/span&gt;&lt;svg&gt;&lt;path&gt;&lt;/path&gt;&lt;/svg&gt;&lt;/span&gt;, &lt;span&gt;&lt;span&gt;NCT01864850&lt;/span&gt;&lt;svg&gt;&lt;path&gt;&lt;/path&gt;&lt;/svg&gt;&lt;/span&gt;.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Findings&lt;/h3&gt;&lt;div&gt;Between Oct 21, 2013, and Aug 22, 2018, 102 patients were randomly assigned to the HSC-RT group and 100 patients to the SF-RT group. One patient in the HSC-RT group refused treatment and follow-up and so was excluded, resulting in 101 patients in the HSC-RT group. Median age was 82 years (IQR 77–86); 145 (72%) were male and 56 (28%) were female. Median follow-up for overall survival was 56·6 months (IQR 41–69). In the intent-to-treat population, 35 (35%) of 101 patients were alive with complete locoregional response at 6 months in the HSC-RT group versus 33 (33%) of 100 patients in the SF-RT group (difference +2%, 95% CI –11 to 15). In the per-protocol population, 35 (36%) of 97 patients were alive with complete locoregional response at 6 months in the HSC-RT group versus 33 (35%) of 95 patients in the SF-RT group (difference +1%, –12 to 15). Median overall survival was 13·0 months (95% CI 10·3 to 17·0) in the HSC-RT group versus 18·9 months (14·3 to 30·9) in the SF-RT group (hazard ratio 1·32, 95% CI 0·97 to 1·81). Eight patients died between radiotherapy start and 30 days after radiotherapy end (five [5%] in the HSC-RT group and three [3%] in the SF-RT group). One patient in the HSC-RT group had a grade 4 adverse event (kidney failure), as did four in the SF-RT group (two mucositis, one septic shock, and one hemiplegia). Acute adverse events grade 3–5 occurred in 33 (36%) of 9","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"7 1","pages":"Article 100812"},"PeriodicalIF":14.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146228958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delirium and adverse clinical outcomes: a matched cohort study in the UK Biobank","authors":"Markus J Haapanen MD PhD ,&nbsp;David D Ward PhD ,&nbsp;Alison M Mudge MBBS PhD ,&nbsp;Emily H Gordon MBBS PhD ,&nbsp;Frederick A Graham BNurs PhD ,&nbsp;Prof Kenneth Rockwood MD ,&nbsp;Prof Ruth E Hubbard MD","doi":"10.1016/j.lanhl.2025.100816","DOIUrl":"10.1016/j.lanhl.2025.100816","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Delirium complicates up to one in four hospitalisations among older adults, but its clinical sequelae beyond cognitive impairment, functional decline, and mortality are not well characterised. Whether delirium signals broader multisystem vulnerability leading to later adverse outcomes remains uncertain. We aimed to examine the association of in-hospital delirium with the occurrence of a range of adverse outcomes during later hospitalisations in the UK.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;We performed a matched cohort study among hospitalised UK Biobank participants recruited in England, Scotland, and Wales in 2006–10 with linked hospital inpatient records collected from Jan 1, 1997 to Oct 31, 2022. We matched 14 909 individuals with delirium (1:1) to hospitalised control individuals without delirium by age, sex, Hospital Frailty Risk Score, primary diagnosis, episode length of stay, and intensive care unit length of stay of the index episode. The primary outcome was the risk of adverse clinical outcomes following delirium. Delirium was identified by ICD-10 codes, with exposure intensity defined as the number of episodes within 12 months of the index admission. Adverse clinical outcomes were selected based on existing literature and included incident events occurring during subsequent hospitalisations: falls, fractures (any and hip), pressure injury, urinary and faecal incontinence, myocardial infarction, heart failure, stroke, venous thromboembolism, pulmonary embolism, acute kidney injury, gastrointestinal bleeding, pneumonia, and sepsis. Fine–Gray subdistribution hazard models accounted for death as a competing risk and adjusted for socioeconomic covariates.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Findings&lt;/h3&gt;&lt;div&gt;Over a maximum follow-up of 26 years, the median time to event was 1·2 years (IQR 0·2–3·3) in the delirium group and 1·3 years (0·3–3·6) in the control group. Delirium was associated with a higher risk of 12 of the 15 adverse clinical outcomes than no delirium, which were urinary incontinence (subdistribution hazard ratio 2·01 [95% CI 1·78–2·28]), falls (1·96 [1·78–2·17]), pressure injury (1·72 [1·53–1·93]), acute kidney injury (1·71 [1·57–1·86]), sepsis (1·67 [1·52–1·84]), hip fracture (1·66 [1·39–2·00]), stroke (1·62 [1·41–1·87]), overall fractures (1·56 [1·40–1·74]), pneumonia (1·53 [1·41–1·65]), faecal incontinence (1·53 [1·31–1·78]), heart failure (1·31 [1·18–1·45]), and gastrointestinal bleeding (1·23 [1·09–1·38]). Each additional episode was associated with a 6–17% higher risk. Findings were consistent across sensitivity analyses excluding individuals with short follow-up, those with prevalent dementia, and the least well-matched pairs.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Interpretation&lt;/h3&gt;&lt;div&gt;In-hospital delirium was consistently and dose-responsively associated with a range of adverse outcomes, independent of frailty and pre-existing dementia, supporting its recognition as a sentinel event indicating longer-term vulnerability.&lt;/","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"7 1","pages":"Article 100816"},"PeriodicalIF":14.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146182769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty and prognosis of biomarker-confirmed Alzheimer’s disease: a Swedish, register-based, retrospective cohort study","authors":"Xin Xia PhD ,&nbsp;Prof Maria Eriksdotter MD ,&nbsp;Prof Henrik Zetterberg MD ,&nbsp;Prof Silke Kern MD ,&nbsp;Tobias Skillbäck PhD ,&nbsp;Marco Toccaceli Blasi MD ,&nbsp;Prof Bengt Winblad MD ,&nbsp;Jonathan K L Mak PhD ,&nbsp;Alice Margherita Ornago MD ,&nbsp;Elena Pinardi MD ,&nbsp;Prof Román Romero Ortuño PhD ,&nbsp;Prof Linus Jönsson MD","doi":"10.1016/j.lanhl.2025.100797","DOIUrl":"10.1016/j.lanhl.2025.100797","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to examine the value of frailty status (defined by the frailty index) in informing the prognosis of people living with Alzheimer’s disease.</div></div><div><h3>Methods</h3><div>In this retrospective cohort study, we used the Swedish Registry for Cognitive/Dementia Disorders linked to other Swedish health-care registers to collect data from May 1, 2007, to Dec 31, 2020. We included people with mild cognitive impairment or Alzheimer’s disease dementia, both with cerebrospinal fluid (CSF) biomarkers supporting Alzheimer’s pathology. We excluded people living in an institution or those who did not have at least one Mini-Mental State Examination (MMSE). We constructed a 41-item frailty index, incorporating diseases, symptoms, polypharmacy, nutritional status, and care dependency. Individuals with frailty index scores of 0·25 or above were considered frail. The associations between frailty and MMSE trajectories, subsequent institutionalisation, and mortality were evaluated by jointly modelling longitudinal and survival data. We also examined whether frailty could modify the associations between CSF amyloid β₄₂, phosphorylated tau₁₈₁, and total tau and cognitive decline.</div></div><div><h3>Findings</h3><div>The study included 7251 individuals (mean age 72·7 years, 4271 [58·9%] females, 2980 [41·1%] males). Frailty was associated with a 0·723-point (95% CI 0·250–1·196) lower baseline MMSE but not with the rate of MMSE decline. Frailty was associated with a hazard ratio of 1·91 (1·43–2·54) for institutionalisation and 2·41 (1·73–3·33) for mortality. Individuals living with frailty had a 1·3-year (0·9–1·7) shorter lifespan and a 1·0-year (0·8–1·3) shorter non-institutionalised lifespan. Associations between CSF biomarkers and MMSE trajectories did not differ by frailty status.</div></div><div><h3>Interpretation</h3><div>Frailty, measured by the frailty index, predicted institutionalisation and mortality in people with Alzheimer’s disease, but its absence of association with cognitive decline suggests neurodegeneration as the primary driver.</div></div><div><h3>Funding</h3><div>Innovative Health Initiative Joint Undertaking and Vinnova.</div></div>","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"6 12","pages":"Article 100797"},"PeriodicalIF":14.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145800637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical effectiveness of music interventions for dementia and depression in older people (MIDDEL): a multinational, cluster-randomised controlled trial","authors":"Vigdis Sveinsdottir PhD ,&nbsp;Jörg Assmus PhD ,&nbsp;Prof Justine Schneider PhD ,&nbsp;Prof Felicity A Baker PhD ,&nbsp;Burçin Uçaner PhD ,&nbsp;Prof Gunter Kreutz PhD ,&nbsp;Monika Geretsegger PhD ,&nbsp;Naomi Rasing PhD ,&nbsp;Jodie Bloska MA ,&nbsp;Phoebe A Stretton-Smith MMusThrp ,&nbsp;Young-Eun C Lee PhD ,&nbsp;Jo Dugstad Wake PhD ,&nbsp;Prof Helen Odell-Miller PhD ,&nbsp;Jeanette Tamplin PhD ,&nbsp;Annemieke C Vink PhD ,&nbsp;Joanne Ablewhite PhD ,&nbsp;Johanna Neuser MSc ,&nbsp;Ulrike Frischen Dr rer Nat ,&nbsp;Prof Antje Timmer PhD ,&nbsp;Prof Thomas Wosch PhD ,&nbsp;Prof Christian Gold PhD","doi":"10.1016/j.lanhl.2025.100783","DOIUrl":"10.1016/j.lanhl.2025.100783","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Dementia and depression are among the leading causes of global disease burden. Effective and scalable interventions are needed to address the effect of these conditions, and music interventions are a promising non-pharmacological approach. The aim of this study was to determine the effectiveness of music interventions on depressive symptoms among care home residents with dementia in Australia, Germany, the Netherlands, Norway, Türkiye, and the UK.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Music Interventions for Dementia and Depression in Elderly care was a large, multinational, cluster-randomised controlled trial with a 2 × 2 factorial design to examine the effects of group music therapy, recreational choir singing, or both compared with standard care. The trial was done in 86 care home units across Australia, Germany, the Netherlands, Norway, Türkiye, and the UK. Care home units were required to host at least ten residents who met the inclusion criteria. Participants were required to be aged 65 years or older; a full-time resident in a participating care home unit; have dementia as indicated by a Clinical Dementia Rating score of 0·5–3 and a Mini-Mental State Examination score of 26 or less; have mild depressive symptoms as indicated by a Montgomery–Åsberg Depression Rating Scale (MADRS) score of at least 8; and a clinical diagnosis of dementia. Care home units with residents with dementia and depressive symptoms were randomly assigned (1:1:1:1; block randomisation stratified by site, using a computer-generated list) to group music therapy, recreational choir singing, a combination of these strategies, or standard care. The primary outcome was MADRS assessed at 6 months in the intention-to-treat population, which included all participants with available data. Assessors were masked but care staff, intervention providers, and residents were not masked due to the nature of the intervention. Intervention effects were analysed with ANCOVA for the total sample and per country. The trial was registered at &lt;span&gt;&lt;span&gt;ClinicalTrials.gov&lt;/span&gt;&lt;svg&gt;&lt;path&gt;&lt;/path&gt;&lt;/svg&gt;&lt;/span&gt;, &lt;span&gt;&lt;span&gt;NCT03496675&lt;/span&gt;&lt;svg&gt;&lt;path&gt;&lt;/path&gt;&lt;/svg&gt;&lt;/span&gt;, and is completed.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Findings&lt;/h3&gt;&lt;div&gt;Between July 18, 2018, and Feb 1, 2023, 86 care home units with 1021 residents were enrolled and randomly assigned to one of the four groups. 22 care home units with 258 residents were randomly assigned to group music therapy, 22 care home units with 281 residents were allocated to recreational choir singing, 21 care home units with 244 residents were assigned to a combination of both group music therapy and recreational choir singing, and 21 care home units with 238 residents were assigned to standard care. The mean age of residents was 85·6 years (SD 7·4); most residents (747 [73·2%]) were female and 274 (26·8%) were male. Intention-to-treat analysis of 751 residents with data at 6 months showed no significant effect on MADRS scores of eit","PeriodicalId":34394,"journal":{"name":"Lancet Healthy Longevity","volume":"6 12","pages":"Article 100783"},"PeriodicalIF":14.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145744907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}