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Clinical and cost-effectiveness of a home-based health promotion intervention for older people with mild frailty in England: a multicentre, parallel-group, randomised controlled trial
IF 13.4 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-02-01 DOI: 10.1016/j.lanhl.2024.100670
Prof Kate Walters PhD , Rachael Frost PhD , Christina Avgerinou PhD , Sarah Kalwarowsky MSc , Prof Claire Goodman PhD , Prof Andrew Clegg MD , Louise Marston PhD , Shengning Pan PhD , Jane Hopkins MA , Claire Jowett , Rekha Elaswarapu , Benjamin Gardner DPhil , Farah Mahmood MSc , Matthew Prescott , Gillian Thornton , Prof Dawn A Skelton PhD , Rebecca L Gould PhD , Prof Claudia Cooper PhD , Prof Vari M Drennan PhD , Kalpa Kharicha PhD , Prof Rachael Hunter PhD
<div><h3>Background</h3><div>Health promotion for people with mild frailty has the potential to improve health outcomes, but such services are scarce in practice. We developed a personalised, home-based, behaviour change, health promotion intervention (HomeHealth) and assessed its clinical effectiveness and cost-effectiveness in maintaining independent functioning in activities of daily living in older adults with mild frailty.</div></div><div><h3>Methods</h3><div>This trial was an individual, multicentre, parallel-group, randomised controlled trial done in England. Participants were mainly recruited from general practices in three different areas of England (the London north Thames region, east and north Hertfordshire, and west Yorkshire). Participants were individuals residing in the community who were registered with a general practice, 65 years and older with mild frailty (scoring 5 on the CFS), with a life expectancy of more than 6 months, and with capacity to consent to participate. We excluded adults residing in nursing or care homes, those with moderate-to-severe frailty or with no frailty, those receiving palliative care, and those already case managed (eg, receiving a similar ongoing intervention from the voluntary sector or community service). Eligible participants were randomly assigned 1:1 to either the HomeHealth intervention or to treatment as usual. HomeHealth is a multidomain health promotion intervention delivered by the voluntary sector at home in six sessions over 6 months. The primary outcome was independent functioning (assessed using the modified Barthel Index [BI]) at 12 months. Outcome assessments were masked and were analysed by intention to treat using linear mixed models. Incremental costs and quality-adjusted life-years (QALYs) were calculated using seemingly unrelated regression and bootstrapping. The trial is registered on the ISRCTN registry (ISRCTN54268283).</div></div><div><h3>Findings</h3><div>We recruited 388 participants between Jan 8, 2021 and July 2, 2022 (mean age 81 years, SD 6·5; 249 (64%) of 388 were women and 139 (36%) were men). 195 participants were randomly assigned to HomeHealth and 193 to treatment as usual. Median follow-up was 363 days (IQR 356–370) in the HomeHealth group and 362 days (IQR 355–373) in the treatment-as-usual group. HomeHealth did not improve BI scores at 12 months (mean difference 0·250, 95% CI –0·932 to 1·432). HomeHealth was superior to treatment as usual with a negative point estimate for incremental costs (–£796; 95% CI –2016 to 424) and positive point estimate for incremental QALYs (0·009, –0·021 to 0·039). There were 55 serious adverse events in the HomeHealth group and 85 in the treatment-as-usual group; none were intervention related.</div></div><div><h3>Interpretation</h3><div>HomeHealth is a safe intervention with a high probability of cost-effectiveness, driven by a reduction in unplanned hospital admissions. HomeHealth should be considered as a health promotion interv
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引用次数: 0
Adopting a complex systems approach to functional ageing: bridging the gap between gerontological theory and empirical research.
IF 13.4 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-01-27 DOI: 10.1016/j.lanhl.2024.100673
Almar A L Kok, Martijn Huisman, Erik J Giltay, Gabriela Lunansky

Functional ageing, related to but distinct from biological and environmental systems, is defined as the changes in physical, psychological, cognitive, and social functioning, as well as behavioural factors of individuals as they age. In this Personal View, we propose that a complex systems perspective to functional ageing can show how outcomes such as quality of life and longevity, and success in prevention and treatment, emerge from dynamic interactions among these domains, rather than from single causes. We support this view in three ways. First, we explain how three key principles of complex systems science-namely, resilience, non-linearity, and heterogeneity-apply to functional ageing. Second, we show how established gerontological theories and geriatric models align with these principles. Third, we illustrate the use of novel methodological tools available from complex systems science for studying functional ageing. Finally, we offer a glossary of key concepts and recommendations for researchers to adopt this perspective in future studies on functional ageing.

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引用次数: 0
The life course approach: setting the stage for healthy ageing
IF 13.4 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-01-01 DOI: 10.1016/j.lanhl.2025.100686
The Lancet Healthy Longevity
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引用次数: 0
Whom to target and when to intervene: insights from the Early Palliative Care in Heart Failure Trial
IF 13.4 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-01-01 DOI: 10.1016/j.lanhl.2024.100671
Moritz Blum , Felix Schönrath
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引用次数: 0
Merits of the social return on investment methodology for assessing the value of palliative care programmes 评估姑息治疗方案价值的社会投资回报方法的优点。
IF 13.4 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-01-01 DOI: 10.1016/j.lanhl.2024.100669
Olivia Monton MD ScM , Emmanuel F Drabo PhD , Shannon Fuller MS , Fabian M Johnston MD MHS
Despite the widely accepted benefits of palliative care for individuals with serious illnesses and their families, the utilisation of this approach remains low. Although an increased use of palliative care services can increase the value of health-care spending by providing comprehensive wraparound services to support care, the economic evidence required to implement, promote, and engage in palliative care models on a wide scale eludes the affected individuals, health-care providers, payers, and policy makers. This gap in evidence is partly owing to the methodological limitations of standard value-assessment frameworks, which do not capture important societal dimensions of the value generated by palliative care. This Personal View proposes the adoption of value-assessment frameworks that incorporate broader dimensions of social value into the evaluation of palliative care programmes. We focus on the social return on investment methodology as an example of a value-assessment framework that can complement standard frameworks to better capture the social impact and all-around benefits of palliative care.
尽管姑息治疗对患有严重疾病的个人及其家属的好处被广泛接受,但这种方法的使用率仍然很低。虽然增加姑息治疗服务的使用可以通过提供全面的一揽子服务来支持护理,从而增加卫生保健支出的价值,但在大范围内实施、促进和参与姑息治疗模式所需的经济证据却没有得到受影响的个人、卫生保健提供者、支付方和决策者的支持。证据方面的差距部分是由于标准价值评估框架在方法上的局限性,这些框架没有捕捉到姑息治疗产生的价值的重要社会层面。本个人观点建议采用价值评估框架,将更广泛的社会价值维度纳入姑息治疗方案的评估。我们将重点放在社会投资回报方法上,作为价值评估框架的一个例子,它可以补充标准框架,以更好地捕捉姑息治疗的社会影响和全面效益。
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引用次数: 0
Frailism: a scoping review exploring discrimination against people living with frailty 脆弱主义:一篇探讨对脆弱人群歧视的范围审查。
IF 13.4 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-01-01 DOI: 10.1016/j.lanhl.2024.100651
Philip Braude MBBS , Emma Grace Lewis PhD , Steve Broach KC MA , Edward Carlton PhD , Sarah Rudd MSc , Jean Palmer , Richard Walker MD , Prof Ben Carter PhD , Prof Jonathan Benger MD
People living with frailty can experience discrimination, but unlike the characteristics of age and disability, frailty is not protected by law. Frailty is a clinical syndrome associated with ageing in which health deficits increase a person’s vulnerability to illness, disability, and death. This scoping review, conducted by a team of methodologists, clinicians, lawyers, and patients, aimed to investigate the extent of discrimination against people living with frailty described in health-care literature. We searched five health-care databases from inception up to June, 2022, and grey literature, to identify 144 texts. The texts were classified by the types of discrimination (direct discrimination, indirect discrimination, harassment, and victimisation) and inductively developed into contextual themes. The median age of the participants was 77 years (IQR 69·9–82·0), and 65·4% were women. The most common types of discrimination were direct (in 90 [63%]), indirect (in 66 [46%]), and harassment (in one [1%]) of the 144 texts, with no instances of victimisation reported. Nine themes of discriminatory actions were developed. Discrimination against people living with frailty overlapped with discrimination based on established protected characteristics, including age, disability, race, and sex. Evidence indicated that frailty discrimination replaces, mediates, masks, and potentiates age discrimination. Discrimination against people with frailty seemed to be both an independent event and one that interacts with established protected characteristics. Future research should focus on preventing frailty-based discrimination and establishing whether frailty should be considered a new protected characteristic by law.
体弱者可能会受到歧视,但与年龄和残疾特征不同,体弱不受法律保护。虚弱是一种与衰老相关的临床综合症,在这种情况下,健康缺陷会增加一个人患病、残疾和死亡的可能性。由方法论专家、临床医生、律师和患者组成的团队进行了此次范围界定审查,旨在调查医疗保健文献中描述的对体弱患者的歧视程度。我们检索了从开始到 2022 年 6 月的五个医疗保健数据库以及灰色文献,确定了 144 篇文献。这些文献按照歧视的类型(直接歧视、间接歧视、骚扰和伤害)进行了分类,并归纳出了相关主题。参与者的年龄中位数为 77 岁(IQR 69-9-82-0),65-4% 为女性。在 144 篇文本中,最常见的歧视类型是直接歧视(90 篇 [63%])、间接歧视(66 篇 [46%])和骚扰(1 篇 [1%]),没有受害情况的报告。共形成了九个歧视行为主题。对体弱者的歧视与基于年龄、残疾、种族和性别等既定受保护特征的歧视重叠。有证据表明,体弱歧视会取代、调解、掩盖和加剧年龄歧视。对体弱者的歧视似乎既是一个独立事件,又与既定的受保护特征相互作用。未来的研究应侧重于防止基于体弱的歧视,并确定法律是否应将体弱视为一种新的受保护特征。
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引用次数: 0
Assessment and management of frailty in individuals living with dementia: expert recommendations for clinical practice 痴呆症患者虚弱的评估和管理:临床实践的专家建议。
IF 13.4 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-01-01 DOI: 10.1016/j.lanhl.2024.100666
Miguel Germán Borda MD PhD , Prof Francesco Landi MD PhD , Prof Tommy Cederholm MD PhD , Luis Carlos Venegas-Sanabria MD PhD , Prof Gustavo Duque MD PhD , Prof Hidetaka Wakabayashi MD PhD , George E Barreto PhD , Isabel Rodriguez-Sanchez MD PhD , Marco Canevelli MD PhD , Carlos Cano-Gutierrez MD , Mario Ulises Pérez-Zepeda MD PhD , Lindsay Wallace PhD , Prof Kenneth Rockwood MD , Mario Salas-Carrillo MD , Martha Gjestsen PhD , Prof Ingelin Testad PhD , Prof Clive Ballard MD PhD , Prof Dag Aarsland MD PhD , IPEFUND
Frailty complicates the care of individuals with dementia, increasing their vulnerability to adverse outcomes. This Personal View presents expert recommendations for managing frailty in individuals with dementia, aimed at health-care providers, particularly those in primary care. We conducted a rapid literature review followed by a consensus process involving 18 international experts on dementia and frailty. The experts identified key areas, including diagnosis of frailty, assessment of nutritional status and nutritional management, physical activity, prevention of falls, and polypharmacy management. The recommendations emphasise early identification of frailty and a comprehensive, interdisciplinary approach to care that aims to maintain the individual’s daily functioning, quality of life, and independence. The recommendations highlight the importance of tailored interventions, regular monitoring, and the integration of psychosocial support into the therapeutic approach. These recommendations address a crucial gap in existing clinical guidelines, offering practical guidance for clinicians managing frailty in individuals with dementia.
虚弱使痴呆症患者的护理复杂化,增加了他们对不良后果的脆弱性。本个人观点提出了针对卫生保健提供者,特别是初级保健提供者的专家建议,以管理痴呆症患者的虚弱。我们进行了一项快速的文献综述,随后由18位痴呆症和虚弱方面的国际专家达成共识。专家们确定了关键领域,包括虚弱诊断、营养状况评估和营养管理、身体活动、预防跌倒和多种药物管理。这些建议强调早期识别虚弱和全面的跨学科护理方法,旨在维持个人的日常功能、生活质量和独立性。这些建议强调了有针对性的干预措施、定期监测以及将社会心理支持纳入治疗方法的重要性。这些建议弥补了现有临床指南中的一个关键空白,为临床医生管理痴呆症患者的虚弱提供了实用指导。
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引用次数: 0
Strengthening social connections to address loneliness in older adults 加强社会联系,解决老年人的孤独问题。
IF 13.4 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-01-01 DOI: 10.1016/j.lanhl.2025.100682
Fang Yang , Danan Gu
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引用次数: 0
Risk prediction for health outcomes in type 2 diabetes: utility of a polysocial risk score? 2型糖尿病健康结局的风险预测:多社会风险评分的效用?
IF 13.4 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-01-01 DOI: 10.1016/j.lanhl.2024.100677
Frank Qian , Samia Mora
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引用次数: 0
The effects of volunteering on loneliness among lonely older adults: the HEAL-HOA dual randomised controlled trial
IF 13.4 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-01-01 DOI: 10.1016/j.lanhl.2024.100664
Prof Dannii Yuen-Lan Yeung PhD , Da Jiang PhD , Prof Lisa Marie Warner PhD , Prof Namkee G Choi PhD , Prof Rainbow Tin Hung Ho PhD , Jojo Yan Yan Kwok PhD , Prof Kee-Lee Chou PhD
<div><h3>Background</h3><div>Previous randomised controlled trials have largely relied on self-reported volunteer work to assess the effects of volunteering and have rarely provided structured volunteering activities during the intervention period. The present study aimed to investigate the effects of social volunteering work over 12 months on loneliness among older adults during the COVID-19 pandemic.</div></div><div><h3>Methods</h3><div>A dual randomised controlled trial was done in Hong Kong to investigate the long-term effects of telephone-delivered psychosocial interventions by older Chinese volunteers who were screened as lonely, for older adult recipients who had low income, lived alone, felt lonely, and were digitally excluded. Participants were included if they were aged 50–70 years; had provided consent to be trained and serve as a volunteer for at least 2 h per week for 6 months; had at least 3 years of secondary school education; had no severe self-reported physical, mental, or cognitive health problems; were not working full or part-time; had engaged in formal volunteering fewer than four times within the past year; and were lonely (ie, had a score of at least 6 on the three-item UCLA Loneliness Scale). Participants were allocated into either the volunteering or control group (psychoeducation programme) using a random number method. The details of group allocation were concealed as the research assistant responsible for randomisation was different to the research assistants responsible for recruitment and assessments (who were masked to the condition). Following a 6-week training, the volunteers delivered a psychosocial intervention to older intervention recipients for 6 months. The primary outcome was loneliness measured with the 20-item UCLA Loneliness Scale and the De Jong Gierveld (DJG) Loneliness Scales at 6 months and 12 months. Assessments were performed before training (baseline; T1), at 6 months (T2), and at 12 months after training (T3). The intention-to-treat principle was used to compare the effects of volunteering between the two groups. The trial was registered in the Clinical Trials Registry of the University of Hong Kong Clinical Trials Centre (HKUCTR-2929). This trial has completed.</div></div><div><h3>Findings</h3><div>Between May 3, 2021, and Oct 6, 2022, a total of 375 individuals were recruited to the trial, including 84 males (22%) and 291 females (78%). 185 were randomly assigned to the volunteering group (56 to deliver a mindfulness intervention, 65 to deliver a behavioural activation intervention, and 64 to deliver a befriending intervention) and 190 were assigned to the control group. 311 (83%) of 375 participants were 60 years or older (median 64 years [SD 4·86]). Participants in the volunteering group reported a significantly lower level of loneliness at T2 (<em>d</em><sub><em>ppc2</em></sub> ranged from −0·41 to −0·70) compared with T1 than participants in the control condition. There was a significant de
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引用次数: 0
期刊
Lancet Healthy Longevity
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