JAAD International最新文献

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Managing large cutaneous squamous cell carcinoma with programmed cell death protein 1 inhibitor monotherapy: Real-world experience at a single center 用 PD-1 抑制剂单药治疗大面积皮肤鳞状细胞癌：单个中心的实际经验。

JAAD International

Pub Date : 2024-05-03 DOI: 10.1016/j.jdin.2024.04.008

Sach Thakker BS , Mairead R. Baker MD , Jafar Al-Mondhiry MA, MD , Sekwon Jang MD , Jennifer A. DeSimone MD

引用次数: 0

Botulinum toxin injection shows promise in nail psoriasis: A comparative randomized controlled trial 肉毒杆菌毒素注射有望治疗甲银屑病：随机对照比较试验

JAAD International

Pub Date : 2024-04-30 DOI: 10.1016/j.jdin.2024.03.021

Premjit Juntongjin MD, Suthima Srisinlapakig MD, MSc, Sunatra Nitayavardhana MD

Background

Nail psoriasis remains a challenging condition with limited satisfaction from current treatments. An increasing number of neuropeptides were reported in psoriatic tissue.

Objective

To compare the efficacy of botulinum toxin A (BoNT-A) injection, triamcinolone acetonide (TA) injection, topical combination of vitamin D/steroid (VitD/steroid) and placebo in improving nail psoriasis.

Methods

A 24-week randomized intraindividual comparative-controlled study involved participants with at least 4 psoriatic fingernails, each with a total target nail psoriasis severity index (NAPSI) score of at least 3 points. Nails were randomly received different treatments; intralesional BoNT-A injection at baseline, intralesional TA at baseline and eighth week, daily topical VitD/steroid application for 16 weeks and placebo.

Results

Evaluation of 64 psoriatic fingernails showed a 40% reduction in the total target NAPSI score at 24 weeks following BoNT-A injection (P = .001). BoNT-A significantly improved nail bed lesions more than TA and topical VitD/steroid (P = .038), with no reported serious adverse effects.

Limitations

Relatively small sample size; hand hygiene during the COVID-19 pandemic may interfere NAPSI score evaluation.

Conclusions

BoNT-A injection emerges as a promising and effective therapy for nail psoriasis, providing sustained efficacy lasting up to 6 months with a single injection.

背景指甲银屑病仍然是一种具有挑战性的疾病，目前的治疗方法难以令人满意。目的比较肉毒毒素 A（BoNT-A）注射、曲安奈德（TA）注射、维生素 D/类固醇（VitD/类固醇）外用组合和安慰剂在改善指甲银屑病方面的疗效。方法一项为期 24 周的随机个体内比较对照研究涉及至少有 4 个指甲银屑病患者，每个患者的目标指甲银屑病严重程度指数（NAPSI）总分至少为 3 分。指甲随机接受了不同的治疗方法：基线注射 BoNT-A、基线和第八周注射 TA、16 周内每天外用 VitD/类固醇激素和安慰剂。结果对 64 例银屑病指甲的评估显示，注射 BoNT-A 后 24 周，目标 NAPSI 总分降低了 40%（P = .001）。BoNT-A对甲床病变的改善明显优于TA和外用VitD/类固醇（P = .038），且无严重不良反应。

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引用次数: 0

Characterization of atopic dermatitis in older adults: A retrospective study 老年人特应性皮炎的特征：回顾性研究

JAAD International

Pub Date : 2024-04-30 DOI: 10.1016/j.jdin.2024.03.028

Hannah Y. Wang BS , Denise C. Robson BS , Joanne S. Jacob MD , Milbrey A. Parke MD , Louisa Y. Liu MD , Soo Jung Kim MD, PhD

引用次数: 0

Epidemiology and primary location of melanoma in Asian patients: A surveillance, epidemiology, and end result–based study 亚洲患者黑色素瘤的流行病学和原发部位：基于 SEER 的研究

JAAD International

Pub Date : 2024-04-24 DOI: 10.1016/j.jdin.2024.04.006

Alim Osman MS , Alexandra R. Nigro MS , Sarah F. Brauer MS , Luis J. Borda MD , Alice A. Roberts MD, PhD

引用次数: 0

Treatment of hidradenitis suppurativa with 755-nm alexandrite laser hair removal: A randomized controlled trial 用 755nm 亚力山大激光脱毛治疗化脓性扁平湿疹：随机对照试验

JAAD International

Pub Date : 2024-04-24 DOI: 10.1016/j.jdin.2024.04.005

Seraphima Sidhom MS , Sarah Utz Petry MD , Rachel Ward MD , Steven Daveluy MD

Background

Hidradenitis supprativa is a chronic inflammatory skin disease that can respond to treatment with laser hair removal.

Objective

To assess alexandrite laser hair removal laser as a treatment for hidradenitis suppurativa as measured by the Hidradenitis Supprativa Clinical Response.

Materials and methods

We conducted a prospective, randomized, controlled study in adult patients with hidradenitis supprativa. Participants underwent a series of 4 monthly laser treatments to 1 side of the body, with the contralateral side serving as a control. The primary outcome was Hidradenitis Supprativa Clinical Response at week 24, 8 weeks after the final laser treatment.

Results

The percent improvement across treated sites after 4 treatments was 72.73% axillary, 70% inguinal, and 100% inframammary. Across all body regions, Hidradenitis Supprativa Clinical Response was significantly higher for the sites treated with the alexandrite laser compared to the contralateral controls: 75% vs 33.33% (P = .0046, 95% CI: [0.16, 1]).

Limitations

The limitations of this study include a small sample size from which the data was collected.

Conclusions

The 775-nm alexandrite laser is a safe and effective treatment for hidradenitis supprativa at various anatomic sites in both resolving preexisting lesions and preventing new eruptions.

背景化脓性扁平湿疹是一种慢性炎症性皮肤病，可对激光脱毛治疗产生反应。目的根据化脓性扁平湿疹临床反应评估紫翠宝石激光脱毛作为化脓性扁平湿疹治疗方法的效果。研究人员每月对身体的一侧进行 4 次激光治疗，对侧作为对照。结果4次治疗后，腋窝、腹股沟和乳房下各治疗部位的改善率分别为72.73%、70%和100%。在所有身体部位，与对侧对照组相比，使用紫翠石激光治疗的部位的Hidradenitis Supprativa临床反应明显更高：结论775 nm紫翠宝石激光器是一种安全有效的治疗方法，可用于不同解剖部位的软化湿疹，既能解决原有病变，又能预防新的糜烂。

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引用次数: 0

Alternating suture and staple placement for linear high-tension scalp wounds: A video walk-through 线性高张力头皮伤口的缝合线和缝合钉交替放置：视频演示

JAAD International

Pub Date : 2024-04-23 DOI: 10.1016/j.jdin.2024.03.027

Spencer P. McClure MD , Edward W. Seger MD, MS , Atieh Jibbe MD

引用次数: 0

A blood-free method of performing slit-skin smears 进行裂隙皮肤涂片的无血方法

JAAD International

Pub Date : 2024-04-23 DOI: 10.1016/j.jdin.2024.01.008

Matthew J. Verheyden BSc (Biomed), MD , Margot J. Whitfeld MBBS, DTM&H , Meciusela Tuicakau MBBS, DipDerm , Antoine Bertolotti MD, PhD

引用次数: 0

Cutaneous and noncutaneous features in patients with neurofibromatosis type 1: A retrospective cohort study including 644 patients 1 型神经纤维瘤病患者的皮肤和非皮肤特征：一项包括 644 名患者的回顾性队列研究

JAAD International

Pub Date : 2024-04-21 DOI: 10.1016/j.jdin.2024.03.010

Kaya L. Curtis BA , Victoria De Barros BS , Samantha Jo Albucker BA , Yuqing Qiu MS , Shari R. Lipner MD, PhD

引用次数: 0

Skin cancers arising within tattoos: A systematic review 对已发表的有关纹身引发皮肤癌的报告进行系统回顾和分析

JAAD International

Pub Date : 2024-04-20 DOI: 10.1016/j.jdin.2024.03.015

Jamie Lebhar BME , Jennifer Jacobs BS , Chandler Rundle MD , Samantha J. Kaplan PhD, MLIS , Paul J. Mosca MD, PhD, MBA

Background

Tattooing is a widespread practice and has increased in popularity over time. Many lesions have been described in relation to tattoos, including malignant tumors.

Objectives

The primary goal of this review is to determine whether the frequency of published cases of skin cancers within tattoos has been increasing over time.

Methods

Our review is in adherence to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and reporting criteria. The databases MEDLINE via PubMed, Embase via Elsevier, and Scopus via Elsevier were searched from inception to February 23, 2023. No data or publication date limits were imposed.

Results

Our review identified 160 cases of cutaneous tumors arising within tattoos. An increase in published cases over time was observed. Most reported tumors developed within red tattoo pigment (36.9%), with the largest contribution by squamous cell carcinoma and keratoacanthoma lesions.

Limitations

There was a lack of consistency of information in published case reports which limited the scope of our analysis. Small sample size was also a limitation of this review.

Conclusions

With the increased popularity of tattoos, it is helpful to continue reporting cases of cutaneous malignancies within tattoos. Awareness of the frequency and severity of tumors within tattoos may be communicated to the public.

背景纹身是一种普遍的行为，而且随着时间的推移越来越受欢迎。本综述的主要目的是确定已发表的文身皮肤癌病例的发生频率是否随着时间的推移而增加。我们检索了从开始到 2023 年 2 月 23 日的数据库：MEDLINE（通过 PubMed）、Embase（通过 Elsevier）和 Scopus（通过 Elsevier）。结果我们发现了 160 例纹身引起的皮肤肿瘤。随着时间的推移，发表的病例也在增加。局限性已发表的病例报告中的信息缺乏一致性，这限制了我们的分析范围。结论随着纹身越来越流行，继续报告纹身中的皮肤恶性肿瘤病例很有帮助。可以向公众宣传纹身内肿瘤的发生频率和严重程度。

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引用次数: 0

Gamification of dermatoscopy education using a smartphone mobile platform: A pilot study 利用智能手机移动平台开展皮肤镜游戏化教育：试点研究

JAAD International

Pub Date : 2024-04-20 DOI: 10.1016/j.jdin.2024.03.008

Shashendra Aponso MD, MRCP , Yue Ting Nichole Tan BSc (Pharm) , Siddharth Jain BCom , Choon Chiat Oh MBBS, MSc

Background

Dermatoscopy is a noninvasive method of examining skin lesions under high magnification, gradually replacing the need for invasive biopsies. Training is required to gain clinical competency. Gamification employs game-like elements to enhance education engagement and is an engaging means of delivering medical education. We sought to use gamification and a mobile-based platform to deliver dermatoscopy education to physicians.

Methods

We developed SKIN@GoPRIME, an interactive smartphone platform. Thirty physician participants were randomly assigned to watch an online dermatoscopy lecture or to use SKIN@GoPRIME. Twenty-eight participants completed prelearning and postlearning quizzes and provided feedback on SKIN@GoPRIME.

Results

Users of SKIN@GoPRIME demonstrated a significant 1.71-point mean score improvement (P = .0018). The group that watched the online dermatoscopy lecture had a higher 2.36-point mean score improvement (P = .00021). Both family medicine and internal medicine physicians demonstrated a significant mean score increase of 1.29 (P = .049) and 2.14 (P = .023), respectively, after using SKIN@GoPRIME. Based on feedback, 83% believed that SKIN@GoPRIME can be used to acquire the applied competencies required for their job scope.

Discussion and Conclusion

SKIN@GoPRIME, a novel learning tool via gamification effectively delivers dermatoscopy education, although it is not shown to be more effective than lectures. Larger studies are required to further validate the effectiveness of gamified learning techniques in dermatoscopy education. Future studies should involve the optimization of SKIN@GoPRIME to more effectively deliver dermatoscopy education.

背景皮肤镜是一种在高倍放大镜下检查皮肤病变的无创方法，逐渐取代了有创活检。要获得临床能力，需要进行培训。游戏化采用类似游戏的元素来提高教育参与度，是一种引人入胜的医学教育手段。我们试图利用游戏化和移动平台为医生提供皮肤镜教育。30 名医生参与者被随机分配观看在线皮肤镜讲座或使用 SKIN@GoPRIME。28 名参与者完成了学习前和学习后的测验，并对 SKIN@GoPRIME.ResultsUsers 进行了反馈，结果显示 SKIN@GoPRIME 的平均得分显著提高了 1.71 分（P = .0018）。观看在线皮肤镜讲座的小组平均得分提高了 2.36 分（P = .00021）。使用 SKIN@GoPRIME 后，家庭医生和内科医生的平均得分分别显著提高了 1.29 分（P = 049）和 2.14 分（P = 023）。根据反馈，83%的人认为SKIN@GoPRIME可用于获得其工作范围所需的应用能力。讨论与结论SKIN@GoPRIME是一种通过游戏化实现的新型学习工具，可有效开展皮肤镜教育，但并未显示其比讲课更有效。要进一步验证游戏化学习技术在皮肤镜教学中的有效性，还需要进行更大规模的研究。未来的研究应包括优化SKIN@GoPRIME，以便更有效地开展皮肤镜教育。

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