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Dynamics of changes in the number of relapses of tuberculosis in Republic of Tajikistan 塔吉克斯坦共和国结核病复发率的动态变化
Pub Date : 2023-03-28 DOI: 10.52888/0514-2515-2023-356-1-13-18
O. Bobokhojaev, B. G. Muminzoda, L. S. Ukumatshoeva, P. U. Mahmydova
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引用次数: 0
Some aspects of the clinic, diagnostics and effectiveness of the treatment of solitary and primary multiple tumors of the nose skin and nosolabial folding (SPMTNSNF) 鼻部皮肤单发和原发多发肿瘤及鼻梁折叠(SPMTNSNF)的临床、诊断和疗效分析
Pub Date : 2023-03-28 DOI: 10.52888/0514-2515-2023-356-1-5-12
N. Bazarov, J. A. Kobilov, J. M. Mazhabov, G. A. Khakimov, Sh. B. Saydahmadov, R. I. Yulchiev, F. I. Shukurov
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引用次数: 0
Assessment of the physical and neuropsychological development of infants born to mothers who underwent COVID-19 during pregnancy 评估怀孕期间感染COVID-19的母亲所生婴儿的身体和神经心理发育
Pub Date : 2023-03-28 DOI: 10.52888/0514-2515-2023-356-1-34-39
T. Ikromov, B. Shamsov, L. F. Jumaeva, B. U. Yangibaeva
{"title":"Assessment of the physical and neuropsychological development of infants born to mothers who underwent COVID-19 during pregnancy","authors":"T. Ikromov, B. Shamsov, L. F. Jumaeva, B. U. Yangibaeva","doi":"10.52888/0514-2515-2023-356-1-34-39","DOIUrl":"https://doi.org/10.52888/0514-2515-2023-356-1-34-39","url":null,"abstract":"","PeriodicalId":345517,"journal":{"name":"Health care of Tajikistan","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132200155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assesmen of atherosclerotic lesions of the carotid artery and risk factors for rheumatoi arthritis patients 风湿性关节炎患者颈动脉粥样硬化病变及危险因素的评估
Pub Date : 2023-03-28 DOI: 10.52888/0514-2515-2023-356-1-24-28
R. N. Zubaidov
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引用次数: 0
The use of a modified blelock taussig anastomosis in the surgical treatment of complex congenital heart defects with univentricular hemodynamics and depleted pulmonary blood flow 改良阻断吻合术在复杂先天性心脏缺损单室血流动力学及肺血流衰竭的外科治疗中的应用
Pub Date : 2023-03-28 DOI: 10.52888/0514-2515-2023-356-1-19-23
J. A. Davlatov, B. U. Abduvokhidov, H. F. Yuldoshev, U. T. Toshpulotov, S. Jobirov
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引用次数: 0
Impact of pregnancy on allosensitization in women with stage 5 chronic kidney disease 妊娠对5期慢性肾脏疾病患者同种异体敏感化的影响
Pub Date : 2023-02-18 DOI: 10.52888/0514-2515-2022-355-4-122-127
I. Usmonov
The article is devoted to the problem of the effect of pregnancy on alloimmunization in women with stage 5 chronic kidney disease and the choice of a donor and immunosuppression for kidney allotransplantation. The analysis showed that alloimmunization of pregnant women is common and remains poorly studied. Studies suggest that endogenous mechanisms contributing to maternal-fetal tolerance during pregnancy may persist in the postpartum period. Moreover, it remains to be determined whether this immunological balance can be used to improve transplant outcomes. Thus, significant opportunities remain for clinical researchers to contribute to this field and improve transplant outcomes for sensitized women. 
本文旨在探讨妊娠对5期慢性肾脏疾病妇女异体免疫的影响,以及异体肾移植的供体选择和免疫抑制问题。分析表明,孕妇的同种异体免疫很常见,但研究仍然很少。研究表明,在怀孕期间促进母胎耐受的内源性机制可能会持续到产后。此外,这种免疫平衡是否可以用于改善移植结果仍有待确定。因此,临床研究人员仍然有很大的机会为这一领域做出贡献,并改善敏感妇女的移植结果。
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引用次数: 0
Combination of duodenal ulcer perforation along with bleeding, penetration and stenosis 十二指肠溃疡穿孔伴出血、渗透及狭窄
Pub Date : 2023-02-18 DOI: 10.52888/0514-2515-2022-355-4-107-111
D. M. Kadyrov, Z. V. Tabarov, F. D. Kodirov, S. S. Saidaliev
This article considers a clinical case of a combination of four complications of duodenal ulcer. Against the background of chronic complications of penetrating ulcer and decompensated duodenostenosis, two acute complications were simultaneously observed - perforation of the ulcer and bleeding from it into the lumen of the GI tract and abdominal cavity. A prolonged course of the disease and the absence of timely surgical treatment of penetrating stenotic ulcer were the reasons for the simultaneous development of two acute complications of duodenal ulcer. Against the background of the severe general condition of the patient, caused by decompensated stenosis with profound homeostasis disorders, alimentary dystrophy, widespread purulent-fibrinous peritonitis and hemoperitoneum, suturing of the perforating ulcer was a necessary operation. At the second stage, it is recommended to perform radical surgery as a planned procedure. 
本文报道一例十二指肠溃疡合并四种并发症的临床病例。以穿透性溃疡和失代偿性十二指肠狭窄为慢性并发症为背景,同时观察到溃疡穿孔和出血进入胃肠道和腹腔两种急性并发症。病程延长及穿透性狭窄性溃疡手术治疗不及时是十二指肠溃疡两种急性并发症同时发生的原因。鉴于该患者一般情况严重,包括失代偿性狭窄伴严重体内平衡紊乱、消化不良、广泛的脓纤维性腹膜炎和腹膜出血,缝合穿孔溃疡是必要的手术。在第二阶段,建议将根治性手术作为计划手术。
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引用次数: 0
Evaluation of the hypocoagulatory role of the lungs using thromboelastography in postpartum women with multiple organ failure 应用血栓弹性成像评价产后多器官功能衰竭妇女肺的降凝作用
Pub Date : 2023-02-18 DOI: 10.52888/0514-2515-2022-355-4-100-106
D. B. Khamidov
Aim. To evaluate the hypocoagulatory role of the lungs in postpartum women with multiple organ failure using thromboelastography.Materials and methods. Sixty-six postpartum women aged 19 to 45 with multiple organ failure were examined. Postpartum women were divided into three groups depending on the nonrespiratory lung function impairment stage.The first group included 23 (34.8%) postpartum women with compensated nonrespiratory pulmonary function; the second group included 24 (36.4%) postpartum women with subcompensated stage of nonrespiratory pulmonary function disorder; the third group included 19 (28.8%) postpartum women with a decompensated form of nonrespiratory pulmonary function disorder.Results and discussion. When analyzing the results of studies in healthy individuals noted TEG constant R reflecting the rate of thromboplastin formation. Thrombin constant K, nonspecific coagulation constant R+K, prothrombin use constant R/K, T - total clotting, syneresis (compaction) C are prolonged in the arterial blood flowing from the lungs compared to the mixed venous blood.Conclusions. In healthy humans, the lungs act as a coagulation filter, reducing the hemostatic potential of the blood. The hypocoagulatory function of the lungs in postpartum women with multiple organ failure is impaired in stages. The thromboelastographic hemostasis study allows rapid and complete assessment of the hypocoagulatory role of the lungs in parturient women with multiple organ failure. 
的目标。应用血栓弹性成像评价产后多器官功能衰竭妇女肺的降凝作用。材料和方法。对66例19 ~ 45岁多器官功能衰竭的产后妇女进行了检查。根据非呼吸性肺功能损害分期将产后妇女分为三组。第一组包括23例(34.8%)具有代偿性非呼吸肺功能的产后妇女;第二组包括24例(36.4%)产后非呼吸性肺功能障碍亚代偿期妇女;第三组包括19名(28.8%)患有非呼吸性肺功能失代偿的产后妇女。结果和讨论。在分析健康个体的研究结果时,注意到TEG常数R反映了凝血活素形成的速率。凝血酶常数K、非特异性凝血常数R+K、凝血酶原使用常数R/K、T -总凝血、凝血作用(压实)C较混合静脉血延长。在健康人身上,肺就像一个凝血过滤器,降低血液的止血潜能。产后多器官功能衰竭妇女的肺低凝功能是分阶段受损的。血栓弹性止血研究可以快速和完整地评估多器官衰竭孕妇肺部的低凝作用。
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引用次数: 0
Prothrombotic state in rheumatoid arthritis 类风湿关节炎的血栓形成前状态
Pub Date : 2023-02-18 DOI: 10.52888/0514-2515-2022-355-4-82-91
N. Seredavkina, F. Cheldieva, A. Lila, T. Reshetnyak
Aim. To study the indices of standard coagulogram and thrombodynamics test in native plasma and in the test with phospholipids in relation to the activity of rheumatoid arthritis (RA) and the ongoing therapy.Material and methods. We examined 28 patients with rheumatoid arthritis and eight age- and sex-matched healthy controls: 11 patients with high rheumatoid arthritis activity (DAS28>5.2) (Group 1), nine patients with low and moderate rheumatoid arthritis activity (DAS28<5.2) (Group 2) and eight rheumatoid arthritis patients receiving anticoagulants (Group 3). Results. Elevated fibrinogen was more common in the RA patient groups: 5/11(45%) in group 1, 3/9(33%) in group 2 and 3/8(38%) in group 3. In the control group, fibrinogen was normal, p><0.05. Increased SFMC was found in all patients in all three groups (100%) and only in 2 of the controls (25%), with p><0.05. Mean clot density was significantly higher in RA groups than in controls: 26811, 25437 and 24740 versus 20631 c.u. in groups 1, 2, 3 and control, respectively, p><0,01. In patients with anticoagulants, lag time (1.4 minutes) was longer than without anticoagulants (1.1-1.2 minutes), with p><0.05 in all cases. Spontaneous clots were detected only in patients: 3 in groups 1 and 1 each in groups 2 and 3. Hypocoagulation was detected only in group 3 in 1/8(12%) patients, and thrombotic readiness status was detected in groups 1 and 2: in 2/11(18%) and 1/9(11%) patients, respectively. The frequency of normal- and hypercoagulation did not differ between the patient and control groups. Conclusion. According to the thrombodynamics test, hypercoagulability is present in RA patients. Thrombodynamics test can be used to identify the risk of thrombosis and to individualize therapy in RA patients. Keywords: prothrombotic state, hypercoagulation, rheumatoid arthritis, thrombodynamics>˂ 5.2) (Group 2) and eight rheumatoid arthritis patients receiving anticoagulants (Group 3).Results. Elevated fibrinogen was more common in the RA patient groups: 5/11(45%) in group 1, 3/9(33%) in group 2 and 3/8(38%) in group 3. In the control group, fibrinogen was normal, p˂ 0.05. Increased SFMC was found in all patients in all three groups (100%) and only in 2 of the controls (25%), with p˂ 0.05. Mean clot density was significantly higher in RA groups than in controls: 26811, 25437 and 24740 versus 20631 c.u. in groups 1, 2, 3 and control, respectively, p˂ 0,01. In patients with anticoagulants, lag time (1.4 minutes) was longer than without anticoagulants (1.1-1.2 minutes), with p˂ 0.05 in all cases. Spontaneous clots were detected only in patients: 3 in groups 1 and 1 each in groups 2 and 3. Hypocoagulation was detected only in group 3 in 1/8(12%) patients, and thrombotic readiness status was detected in groups 1 and 2: in 2/11(18%) and 1/9(11%) patients, respectively. The frequency of normal- and hypercoagulation did not differ between the patient and control groups.Conclusion. According to the thrombodynamics test,
的目标。目的:探讨类风湿性关节炎(RA)患者血浆标准凝血仪、血栓动力学试验指标、磷脂试验指标与RA活动度的关系及治疗进展。材料和方法。我们检查了28例类风湿关节炎患者和8例年龄和性别匹配的健康对照:11例类风湿关节炎高活度患者(DAS28依据依据:5.2)(1组),9例类风湿关节炎低度和中度活度患者(DAS28依据依据:5.2)(2组)和8例类风湿关节炎患者接受抗凝治疗(3组)。纤维蛋白原升高在RA患者组中更为常见:1组5/11(45%),2组3/9(33%),3组3/8(38%)。对照组纤维蛋白原正常,p < 0.05。三组患者SFMC均升高(100%),对照组仅有2例(25%),p值小于0.05。RA组的平均血凝块密度显著高于对照组:1、2、3组和对照组的血凝块密度分别为26811、25437和24740,p值小于0.001。在使用抗凝药物的患者中,延迟时间(1.4分钟)比未使用抗凝药物的患者(1.1-1.2分钟)长,p值均小于0.05。自发性血块仅在患者中检测到:1组3例,2组和3组各1例。第3组只有1/8(12%)的患者检测到低凝,第1组和第2组分别有2/11(18%)和1/9(11%)的患者检测到血栓形成准备状态。正常凝血和高凝血的频率在患者和对照组之间没有差异。根据血栓动力学试验,RA患者存在高凝性。血栓动力学试验可用于识别RA患者的血栓形成风险和个体化治疗。
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引用次数: 1
Modern principles of diagnostics of acute destructive pancreatitis 急性破坏性胰腺炎的现代诊断原则
Pub Date : 2023-02-18 DOI: 10.52888/0514-2515-2022-355-4-112-122
S. Nazarov, S. Alizade, J. K. Ayubov, T. Nazarov, K. N. Nosiri, E. I. Asadulloeva
The incidence of acute destructive pancreatitis is steadily increasing worldwide and, according to the recent literature, is 300-900 patients/mil per year. The increased lethality rate of acute destructive pancreatitis in recent decades, which according to global statistics, ranges from 5% to 20% depending on the severity of the disease, is a cause for concern. It should be noted that most patients with acute destructive pancreatitis are working-age patients, which significantly increases the socio-economic aspect of the problem and urgently requires an active search for ways to solve it. It has been established that the leading pathogenetic mechanism of acute destructive pancreatitis development is enzymatic autolysis of pancreatic parenchyma by its enzymes with their subsequent release into the bloodstream and damage of other organs. 
急性破坏性胰腺炎的发病率在世界范围内稳步上升,根据最近的文献,每年为300-900例患者/百万人。近几十年来,急性破坏性胰腺炎的死亡率不断上升,根据全球统计数据,根据疾病的严重程度,死亡率在5%至20%之间,这是一个令人担忧的问题。应该指出的是,大多数急性破坏性胰腺炎患者都是工作年龄的患者,这大大增加了该问题的社会经济方面,迫切需要积极寻找解决方法。已经确定急性破坏性胰腺炎发展的主要发病机制是胰实质酶的酶自溶,随后释放到血液中并损害其他器官。
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引用次数: 1
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Health care of Tajikistan
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