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Morphofunctional changes in the small intestine in acute adhesive small bowel obstruction 急性粘连性小肠梗阻小肠形态功能改变
Pub Date : 2023-02-15 DOI: 10.52888/0514-2515-2022-355-4-11-16
M. Gulzoda, B. I. Safarov, K. R. Ruziboyzoda, K. K. Kobilov
Aim: To study the features of morpho-functional changes in the small intestine mucosa in acute adhesive small bowel obstruction.Material and methods. The results of a comprehensive study of morphological and functional changes in the small intestine’s mucous membrane in 20 patients out of 50 with acute adhesive small intestinal obstruction were analyzed. Patients underwent resection of the small intestine with a biopsy from the mucous membrane, followed by a pathomorphological and biochemical examination of biopsy specimens.Results. The study results show that more pronounced pathomorphological changes in the mucous membrane of the small intestine were observed in patients with acute adhesive small intestinal obstruction with widespread (multiple) adhesions compared with limited (single) adhesions. In the study of biochemical parameters in the small intestine mucosa in patients with acute adhesive small intestinal obstruction with the presence of multiple (widespread) adhesions, there was a significant and critical increase in lipid peroxidation and proinflammatory cytokines, a decrease in antioxidant protection compared to the patient group with the presence of single (limited) adhesions. There was also a decrease in the concentration of serotonin in the mucosa of the small intestine. In the presence of single (limited) adhesions in these patients, it decreases to 0,50±0,3 units, and in patients with multiple (common) adhesions - to 0,20±0,2 arb. units.Conclusion. The severity of morpho-functional changes in the mucosa of the small intestine directly correlates with the severity of the development of the adhesive process and acute adhesive small bowel obstruction. 
目的:探讨急性粘连性小肠梗阻小肠黏膜形态功能变化特点。材料和方法。本文对50例急性粘连性小肠梗阻患者中的20例进行了小肠粘膜形态学和功能变化的综合研究。患者接受小肠切除术和粘膜活检,然后对活检标本进行病理形态学和生化检查。研究结果表明,急性粘连性小肠梗阻伴广泛(多发)粘连患者的小肠黏膜病理形态学改变较伴局限性(单一)粘连患者更为明显。在多发性(广泛)粘连的急性粘连性小肠梗阻患者的小肠黏膜生化参数研究中,与单一(有限)粘连患者组相比,脂质过氧化和促炎细胞因子显著且临界增加,抗氧化保护能力下降。小肠黏膜的血清素浓度也有所下降。在这些患者中存在单一(有限)粘连时,它降低到0,50±0,3个单位,在多个(常见)粘连的患者中-降低到0,20±0,2 arb。units.Conclusion。小肠黏膜形态功能改变的严重程度与粘连过程发展的严重程度和急性粘连性小肠梗阻直接相关。
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引用次数: 0
Current views on the etiology, classification, diagnosis, treatment of chemical burns and post-burn scar stenosis of the esophagus in children 儿童化学性烧伤及烧伤后瘢痕性食管狭窄的病因、分类、诊断及治疗现状
Pub Date : 2022-11-13 DOI: 10.52888/0514-2515-2022-354-3-108-119
A. M. Sharipov, B. H. Yusupov
This review analyzes different scientific views on the diagnosis and treatment of chemical burns of the esophagus and its consequences - the formation of cicatricial stenosis of the organ. Post-burn scar stenosis of the esophagus in pediatric surgery is a fairly common disease that is formed in children with chemical burn of the 3rd degree. In the study of this pathology a timely diagnosis between the degrees of esophageal burns and the correct selection of patients for dilatation of the organ is of particular interest for the correct treatment of patients.
本文就食道化学烧伤的诊断和治疗及其后果——瘢痕性食道狭窄的形成,分析不同的科学观点。在小儿手术中,食道烧伤后瘢痕狭窄是一种相当常见的疾病,发生在三度化学烧伤的儿童中。在该病理研究中,及时诊断食管烧伤程度和正确选择患者进行器官扩张对患者的正确治疗具有特别重要的意义。
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引用次数: 0
Features of the hemostasis system in COVID-19 COVID-19患者止血系统的特点
Pub Date : 2022-11-13 DOI: 10.52888/0514-2515-2022-354-3-102-108
A. Muradov, A. A. Ibragimova, N. Z. Nazirova, U. S. Valieva, M. Shumilina
The objective difficulties of managing patients with SARS-CoV-2 infection have attracted the attention of the global medical and scientific community. Despite the optimal treatment, in some cases a cascade of reactions is triggered. It leads to a deterioration in the clinical condition of patients, up to a fatal outcome. The article presents current research data on the pathogenesis, clinical and laboratory features of COVID-19 associated coagulopathy.
SARS-CoV-2感染患者管理的客观困难引起了全球医学界和科学界的关注。尽管有最佳的治疗方法,但在某些情况下会引发一连串的反应。它会导致患者的临床状况恶化,直至致命的结果。本文介绍了COVID-19相关凝血病的发病机制、临床和实验室特征的最新研究数据。
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引用次数: 0
Selection of a modern strategy for the treatment of acute coronary syndrome with elevated ST segment ST段抬高急性冠状动脉综合征现代治疗策略的选择
Pub Date : 2022-11-13 DOI: 10.52888/0514-2515-2022-354-3-119-127
S. Shukurova, R. H. Kabirzoda, G. M. Radzhabova, H. F. Rakhmatulloev, A. I. Faizulloev
The review is based on the analysis of current literature data on acute coronary syndrome (ACS): definition, epidemiology, classification, and methods of modern therapy methods. The article presents in detail the premedication and reperfusion strategies of introduction with an emphasis on a differential approach in the choice of therapy depending on the state of the ST-segment elevation. According to the literature the choice of treatment differs in patients with ACS with ST. The results of multicenter studies on the use of anticoagulant therapy in ACS and the need for double anticoagulant therapy against the background of the use of statins, ACE inhibitors, and beta blockers are presented.
本文就急性冠脉综合征(ACS)的定义、流行病学、分类及现代治疗方法进行综述。本文详细介绍了引入的药物前治疗和再灌注策略,重点是根据st段抬高的状态选择不同的治疗方法。根据文献,ACS合并st患者的治疗选择不同。本文介绍了ACS抗凝治疗的多中心研究结果,以及在使用他汀类药物、ACE抑制剂和受体阻滞剂的背景下,需要双重抗凝治疗。
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引用次数: 0
Multiple complications of postbulbar parapapillary ulcer combined with arteriomesenteric compression of the duodenum 球后乳头旁溃疡合并十二指肠动肠系膜压迫的多重并发症
Pub Date : 2022-11-13 DOI: 10.52888/0514-2515-2022-354-3-83-89
D. M. Kadyrov, Z. V. Tabarov, F. D. Kodirov, S. S. Saidaliev, V. S. Sharipov
The article explores a clinical observation of a giant postbulbar parapapillary duodenal ulcer with multiple combined complications in the form of penetration into the pancreas, acute gastroduodenal bleeding and subcompensated stenosis occurred against the background of arterio-mesenteric compression of the duodenum in the subcompensation stage. The long course of the disease contributed to the development of alimentary dystrophy, cachexia and severe anemia. After stopping the bleeding, carrying out adequate preoperative preparation, the patient underwent Roux-en-Y gastric resection to “turn off” the ulcer with demucosation of the antrum and formation of the epipyloric stump of the duodenum according to the method modified in the clinic. The postoperative period was complicated by the development of a fistulous variant of duodenal stump suture failure, which was conservatively eliminated. The patient recovered.
本文探讨了在十二指肠亚代偿期以动脉-肠系膜压迫十二指肠为背景,发生巨大的球后十二指肠乳头旁溃疡,并发浸润胰腺、急性胃十二指肠出血和亚代偿性狭窄等多重合并并发症的临床观察。长期病程导致消化道营养不良、恶病质和严重贫血。止血后,做好术前准备,按照临床修改的方法行Roux-en-Y胃切除术,“关闭”胃溃疡,清除胃窦黏膜,形成十二指肠上幽门残端。术后期间由于十二指肠残端缝合失败发生瘘变而变得复杂,保守地消除了这种情况。病人康复了。
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引用次数: 0
Modern surgery of combined nose pathologies and paranasal sinuses 现代鼻病及副鼻窦联合外科
Pub Date : 2022-11-13 DOI: 10.52888/0514-2515-2022-354-3-96-102
M. I. Makhmudnazarov
The review article is devoted to the issues of surgical treatment and postoperative rehabilitation of patients with deformity of the nose, combined with the pathology of the nasal cavity and paranasal sinuses. Analysis of the literature shows that in terms of the tactics of surgical treatment of patients with nasal deformity, combined with the pathology of the nasal cavity and paranasal sinuses, there is no consensus, and the development of more effective methods of simultaneous surgical treatment remains a subject of discussion.
这篇综述文章结合鼻腔和副鼻窦的病理,讨论了鼻畸形患者的手术治疗和术后康复问题。文献分析表明,在鼻畸形患者的手术治疗策略方面,结合鼻腔和鼻窦的病理情况,尚未达成共识,开发更有效的手术同时治疗方法仍是一个讨论的主题。
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引用次数: 1
Organization of medical care to cancer patients during Covid-19 pandemic and postcovid period 新冠肺炎大流行期间及后时期癌症患者的医疗护理组织
Pub Date : 2022-11-13 DOI: 10.52888/0514-2515-2022-354-3-89-96
J. Abdullozoda, J. R. Sanginov, Z. K. Huseynzoda
The article touches upon the problem of coronavirus infection as a serious problem of the public health system at the current stage. The activity of different subdivisions of the oncological service of the republic was analyzed, the features and tendencies of their functioning were noted and conclusions on the correction of diagnostics and treatment of oncological diseases were made. The results of foreign multicenter studies related to the impact of COVID-19 on the activities of cancer services in different countries and regions and their recommendations were also studied. Cancer patients are the most vulnerable group, as they are at high risk of immunosuppression, are elderly, and have comorbidities (diabetes, cardiovascular). The manifestation of post-COVID19 syndrome becomes relevant and requires further study.
本文论述了冠状病毒感染问题是现阶段公共卫生系统的一个严重问题。分析了共和国肿瘤服务不同部门的活动,指出了其功能的特点和趋势,并就肿瘤疾病的诊断和治疗的纠正作出了结论。本文还研究了国外关于新冠肺炎对不同国家和地区癌症服务活动影响的多中心研究结果及其建议。癌症患者是最脆弱的群体,因为他们免疫抑制的风险高,年龄大,并有合并症(糖尿病,心血管)。covid - 19后综合征的表现具有相关性,需要进一步研究。
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引用次数: 0
Cognitive impairment in patients with hypothyroidism and possibilities of its correction 甲状腺功能减退患者的认知障碍及其矫正的可能性
Pub Date : 2022-11-12 DOI: 10.52888/0514-2515-2022-354-3-66-71
E. V. Chernyadeva
Aim. To identify and correct cognitive impairment in patients with hypothyroidism.Materials and methods. The study included 76 patients with primary hypothyroidism. All patients were divided into 2 groups: compensated and decompensated hypothyroidism. In addition to general clinical, and hormonal blood tests all participants in the study underwent ultrasound of the thyroid gland and ECG, the neurophysiological study of cognitive evoked potentials, and testing according to the Montreal cognitive function assessment scale.Results. In the majority of patients with a lack of thyroid hormones, cognitive impairments were detected, which increase with worsening compensation for hypothyroidism according to the results of Montreal Cognitive Assessment Scale testing. The study of evoked potentials in patients with hypothyroidism revealed an increase in latency and a decrease in the amplitude of the P300 indicator, indicating the presence of cognitive deficit. The addition of ethylmethylhydroxypyridine succinate to hormone replacement therapy in patients with hypothyroidism significantly improves cognitive performance more than hormone monotherapy.Conclusions. This study showed the need to identify cognitive impairments in patients with primary hypothyroidism, and their correction with the help of complex therapy increases the cognitive potential and the effectiveness of their treatment.
的目标。目的:鉴别和纠正甲状腺功能减退患者的认知功能障碍。材料和方法。该研究包括76例原发性甲状腺功能减退患者。所有患者分为代偿性和失代偿性甲状腺功能减退2组。除了一般的临床和激素血液检查外,所有研究参与者都进行了甲状腺超声检查和心电图,认知诱发电位的神经生理学研究,并根据蒙特利尔认知功能评估量表进行了测试。在大多数甲状腺激素缺乏的患者中,发现认知障碍,根据蒙特利尔认知评估量表测试结果,随着甲状腺功能减退代偿的加重,认知障碍增加。甲状腺功能减退患者的诱发电位研究显示潜伏期增加,P300指标幅度降低,提示存在认知缺陷。甲状腺功能减退患者在激素替代治疗中加入丁二酸乙基甲基羟吡啶比单激素治疗更能显著改善认知能力。本研究表明,原发性甲状腺功能减退患者需要识别认知障碍,并在综合治疗的帮助下进行纠正,以增加认知潜能和治疗效果。
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引用次数: 0
Frequency and structure of congenital fetal malformations in the new socioeconomic conditions 新社会经济条件下先天性胎儿畸形的频率和结构
Pub Date : 2022-11-12 DOI: 10.52888/0514-2515-2022-354-3-41-47
B. T. Mirzabekova, H. O. Saidova, S. M. Mukhamadieva, Sh. J. Saydahmadova
Aim. To identify the frequency and the structure of congenital malformations in the new socio-economic conditions of the region for the period betwee 2014-2018.Material and methods. Annual statistical data of form 32 “Report on the provision of medical care to pregnant women, women in labor and newborns”, approved by No. 54 of 11.11.2014, of the Center for Medical Statistics and Information of the Ministry of Health and Social Protection of the Republic of Tajikistan for the period 2014-2018 were analyzed.Results and discussion. In the new socio-economic conditions of the country, a high frequency of congenital malformations has been established, which has an unstable tendency to decrease. The findings indicate that congenital malformations occur mainly among premature newborns, while lesions of the central nervous system prevail. Defects of the cardiovascular system prevail among full-term infants, which is possibly associated with the late diagnosis of the pathology.Conclusion. Perinatal screening will allow timely detection of congenital malformations of the fetus, reduce perinatal morbidity and mortality.
的目标。确定2014-2018年该地区新社会经济条件下先天性畸形的频率和结构。材料和方法。对塔吉克斯坦共和国卫生和社会保障部医学统计和信息中心2014年11月11日第54号法令批准的2014-2018年期间《关于向孕妇、产妇和新生儿提供医疗服务的报告》表格32的年度统计数据进行了分析。结果和讨论。在该国新的社会经济条件下,先天性畸形的发病率很高,而且有不稳定的下降趋势。研究结果表明,先天性畸形主要发生在早产儿中,而中枢神经系统病变则普遍存在。足月儿普遍存在心血管系统缺陷,这可能与病理诊断较晚有关。围产期筛查可以及时发现胎儿的先天性畸形,降低围产期的发病率和死亡率。
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引用次数: 0
Treatment of neuromuscular dysplasia of the vesicoureteral segment of the ureters in children 儿童输尿管膀胱输尿管段神经肌肉发育不良的治疗
Pub Date : 2022-11-12 DOI: 10.52888/0514-2515-2022-354-3-34-41
H. Ibodov, K. Mirakov, R. Rofiev, A. Davlatov, N. S. Ibodov
Aim. To optimize conservative and surgical treatment of neuromuscular dysplasia of the vesicoureteral segment in children.Materials and methods. Study included 84 operated children with neuromuscular dysplasia of the vesicoureteral segment of the ureters. Megaureter antenatally diagnosed in 28 (25.4%) children: Ι degree - in 5, II degree - in 9, III degree - in 10, IV degree - in 4 children. The main criteria for diagnosing a megaureter in the perinatal period are an expansion of the anterior-posterior size of the pelvis, visualization of the dilated ureter, and in СFM - identification of weakening of the renal blood flow in the affected side.Results and discussion. As a result of the conservative and minimally invasive therapy – stenting of the ureters for up to 2 years, urodynamics were restored and the phenomena of ureterohydronephrosis were eliminated in 30 (27.2%) patients. In 32 (29%) patients, percutaneous puncture nephrostomy was performed, aimed at reducing the collecting system of the kidney, and ureter, as well as preparing for surgical treatment. The operated patients (84) were divided into 3 groups: Group I - operated according to the Politano-Ledbetter method (29); Group II - according to Cohen (20); Group III operated according to the method of extravesical reimplantation of the ureter with antireflux protection, developed in the clinic of pediatric surgery (35). Complications were noted in 8 (27.5%) patients after the Politano-Ledbetter operation; in 4 (20%) cases after the Cohen method operation; and in 5 (14.2%) cases after the extravesical reimplantation with antireflux protection.Conclusion. The method of ureteral reimplantation, developed and tested at the Clinic of Pediatric Surgery, is a fairly effective way to treat megareteral disease in children. This technique is highly effective in children older than 1-3 years, which makes 85.8%.
的目标。目的:优化儿童膀胱输尿管段神经肌肉发育不良的保守和手术治疗方法。材料和方法。研究对象为84例输尿管膀胱输尿管段神经肌肉发育不良手术患儿。在28名(25.4%)儿童中进行了产前诊断:Ι度- 5人,II度- 9人,III度- 10人,IV度- 4人。围产期诊断尿量计的主要标准是骨盆前后尺寸的扩张,输尿管扩张的可视化,以及СFM -识别受累侧肾血流的减弱。结果和讨论。经保守微创输尿管支架治疗2年,30例(27.2%)患者尿动力学恢复,输尿管肾积水消除。32例(29%)患者行经皮穿刺肾造口术,目的是减少肾脏和输尿管的收集系统,为手术治疗做准备。手术患者84例,分为3组:第一组,采用Politano-Ledbetter法(29例);第二组-根据Cohen (20);III组采用小儿外科临床发展的输尿管体外再植抗反流保护方法(35)。8例(27.5%)患者术后出现并发症;Cohen法术后4例(20%);5例(14.2%)术后有抗反流保护。输尿管再植术是儿科外科诊所开发和试验的一种相当有效的治疗儿童巨肠管疾病的方法。这种方法对1-3岁以上的儿童非常有效,占85.8%。
{"title":"Treatment of neuromuscular dysplasia of the vesicoureteral segment of the ureters in children","authors":"H. Ibodov, K. Mirakov, R. Rofiev, A. Davlatov, N. S. Ibodov","doi":"10.52888/0514-2515-2022-354-3-34-41","DOIUrl":"https://doi.org/10.52888/0514-2515-2022-354-3-34-41","url":null,"abstract":"Aim. To optimize conservative and surgical treatment of neuromuscular dysplasia of the vesicoureteral segment in children.Materials and methods. Study included 84 operated children with neuromuscular dysplasia of the vesicoureteral segment of the ureters. Megaureter antenatally diagnosed in 28 (25.4%) children: Ι degree - in 5, II degree - in 9, III degree - in 10, IV degree - in 4 children. The main criteria for diagnosing a megaureter in the perinatal period are an expansion of the anterior-posterior size of the pelvis, visualization of the dilated ureter, and in СFM - identification of weakening of the renal blood flow in the affected side.Results and discussion. As a result of the conservative and minimally invasive therapy – stenting of the ureters for up to 2 years, urodynamics were restored and the phenomena of ureterohydronephrosis were eliminated in 30 (27.2%) patients. In 32 (29%) patients, percutaneous puncture nephrostomy was performed, aimed at reducing the collecting system of the kidney, and ureter, as well as preparing for surgical treatment. The operated patients (84) were divided into 3 groups: Group I - operated according to the Politano-Ledbetter method (29); Group II - according to Cohen (20); Group III operated according to the method of extravesical reimplantation of the ureter with antireflux protection, developed in the clinic of pediatric surgery (35). Complications were noted in 8 (27.5%) patients after the Politano-Ledbetter operation; in 4 (20%) cases after the Cohen method operation; and in 5 (14.2%) cases after the extravesical reimplantation with antireflux protection.Conclusion. The method of ureteral reimplantation, developed and tested at the Clinic of Pediatric Surgery, is a fairly effective way to treat megareteral disease in children. This technique is highly effective in children older than 1-3 years, which makes 85.8%.","PeriodicalId":345517,"journal":{"name":"Health care of Tajikistan","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128531098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Health care of Tajikistan
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