Background: Improving programs for early prenatal detection of congenital malformations remains a relevant scientific and practical problem. The prevalence of congenital anomalies in Ukraine is 23.7:1000 among live-born babies, and there is no significant decrease in it. The aim of this study was to compare clinical, ultrasound and cytogenetic data in swollen fetuses with increased nuchal translucency (NT) thicknesses from the group of pregnant women in the first trimester at high genetic risk to optimize the algorithm of prenatal diagnostics. Materials and Methods: Clinical examinations, ultrasound diagnostics, invasive methods of prenatal diagnostics (chorion biopsy, amniocentesis), genetic testing techniques, such as karyotyping and FISH, genetic counseling and statistical analysis were carried out. The results of complex examinations of 127 fetuses with an increased NT thickness from the group of pregnant women were analyzed. Fetuses were divided into two groups with an NT thickness of 2.5–3.5 mm (group 1) (38 cases) and with an NT above 3.5 mm (group 2)(89 cases). Results: Among pregnancies with fetuses with an increased NT thickness, there were 65.4% cases of adverse outcomes with chromosomal pathology (69.9%), congenital malformations of non-chromosomal etiology (25.3%) and pregnancy loss (4.8%). The frequency of chromosomal abnormalities in fetuses of group 1 was 55.3% and 41.6% in group 2. Congenital malformations of various systems and organs in fetuses, the most frequent of which were cardiac defects, were diagnosed. The ratio of congenital heart defects in the fetuses of groups 1 and 2 was 23.7% and 43.8%, respectively (p=0.03; OR=0.40). Conclusion: There is no significant difference between the frequency of chromosomal abnormalities in the fetuses of group 1 compared to group 2, which indicates a high informative value of an increased NT thickness, including the thickness of 2.5–3.5 mm in fetuses in the first trimester as a marker of chromosomal pathology. A significantly higher incidence of congenital malformations of non-chromosomal etiology was found in fetuses with venous duct pathology and NT thickness over 3.5 mm compared to fetuses with the same pathology and NT thickness of 2.5–3.5 mm. Proposed changes to the management algorithm for pregnant women with swollen fetuses include mandatory congenital heart defects screening in the first trimester.
背景：改进产前早期发现先天性畸形的计划仍然是一个相关的科学和实际问题。在乌克兰，先天性畸形在活产婴儿中的发病率为 23.7:1000，且没有明显下降。本研究旨在比较高遗传风险孕妇群体中颈透明层（NT）厚度增加的肿胀胎儿的临床、超声和细胞遗传学数据，以优化产前诊断算法。 材料与方法：进行了临床检查、超声诊断、有创产前诊断方法（绒毛活检、羊膜腔穿刺术）、基因检测技术（如核型和 FISH）、遗传咨询和统计分析。对孕妇组中 127 个 NT 厚度增高胎儿的综合检查结果进行了分析。胎儿被分为两组，NT 厚度为 2.5-3.5 毫米（第 1 组）（38 例）和 NT 厚度超过 3.5 毫米（第 2 组）（89 例）。 结果在 NT 厚度增加的孕妇中，65.4% 的胎儿出现不良结局，包括染色体病变（69.9%）、非染色体病因的先天畸形（25.3%）和妊娠失败（4.8%）。第一组胎儿染色体异常的频率为 55.3%，第二组为 41.6%。胎儿各系统和器官的先天畸形均已确诊，其中最常见的是心脏缺陷。第 1 组和第 2 组胎儿的先天性心脏缺陷比例分别为 23.7%和 43.8%（P=0.03；OR=0.40）。 结论第 1 组胎儿的染色体异常频率与第 2 组胎儿的染色体异常频率相比无明显差异，这表明 NT 厚度增加（包括前三个月胎儿 NT 厚度为 2.5-3.5 mm）作为染色体病变的标志物具有很高的参考价值。在静脉导管病变和 NT 厚度超过 3.5 毫米的胎儿中，非染色体病因的先天畸形发生率明显高于同样病变和 NT 厚度为 2.5-3.5 毫米的胎儿。建议对胎儿浮肿孕妇的管理算法进行修改，包括在妊娠头三个月进行强制性先天性心脏缺陷筛查。
{"title":"CLINICAL, ULTRASOUND AND CYTOGENETIC CHARACTERISTICS OF FETUSES WITH INCREASED NUCHAL TRANSLUCENCY THICKNESS IN THE FIRST TRIMESTER OF PREGNANCY","authors":"Natalia Prokopchuk, Marharyta Nikolenko, Mariya Lozynska, Olha Antoniuk, Yaroslav Korinetz, Yuriy Ivaniv","doi":"10.25040/ntsh2023.02.15","DOIUrl":"https://doi.org/10.25040/ntsh2023.02.15","url":null,"abstract":"Background: Improving programs for early prenatal detection of congenital malformations remains a relevant scientific and practical problem. The prevalence of congenital anomalies in Ukraine is 23.7:1000 among live-born babies, and there is no significant decrease in it. The aim of this study was to compare clinical, ultrasound and cytogenetic data in swollen fetuses with increased nuchal translucency (NT) thicknesses from the group of pregnant women in the first trimester at high genetic risk to optimize the algorithm of prenatal diagnostics. Materials and Methods: Clinical examinations, ultrasound diagnostics, invasive methods of prenatal diagnostics (chorion biopsy, amniocentesis), genetic testing techniques, such as karyotyping and FISH, genetic counseling and statistical analysis were carried out. The results of complex examinations of 127 fetuses with an increased NT thickness from the group of pregnant women were analyzed. Fetuses were divided into two groups with an NT thickness of 2.5–3.5 mm (group 1) (38 cases) and with an NT above 3.5 mm (group 2)(89 cases). Results: Among pregnancies with fetuses with an increased NT thickness, there were 65.4% cases of adverse outcomes with chromosomal pathology (69.9%), congenital malformations of non-chromosomal etiology (25.3%) and pregnancy loss (4.8%). The frequency of chromosomal abnormalities in fetuses of group 1 was 55.3% and 41.6% in group 2. Congenital malformations of various systems and organs in fetuses, the most frequent of which were cardiac defects, were diagnosed. The ratio of congenital heart defects in the fetuses of groups 1 and 2 was 23.7% and 43.8%, respectively (p=0.03; OR=0.40). Conclusion: There is no significant difference between the frequency of chromosomal abnormalities in the fetuses of group 1 compared to group 2, which indicates a high informative value of an increased NT thickness, including the thickness of 2.5–3.5 mm in fetuses in the first trimester as a marker of chromosomal pathology. A significantly higher incidence of congenital malformations of non-chromosomal etiology was found in fetuses with venous duct pathology and NT thickness over 3.5 mm compared to fetuses with the same pathology and NT thickness of 2.5–3.5 mm. Proposed changes to the management algorithm for pregnant women with swollen fetuses include mandatory congenital heart defects screening in the first trimester.","PeriodicalId":345961,"journal":{"name":"Proceeding of the Shevchenko Scientific Society. Medical Sciences","volume":"32 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139166015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. In modern societal conditions, the pathology of the affective sphere occupies a special place among general medical problems. One of the central phenomena, both in depression and in another common affective disorder – mania, is the issue of self-esteem. Aim. To study the presence of depressive disorders depending on the presence of the inferiority phenomenon. Methods of research. The study uses data from the survey of 612 university students of higher education institutions of III and IV accreditation in Lviv, conducted in October – November 2021. Among the respondents, 57.35% (n=351) were men and 42.65% (n=261) were women. The average age of respondents was 20.31±2.99. Respondents filled out questionnaires of the Comparative Feeling of Inferiority Index (CFII) to determine the presence or absence of phenomenon of inferiority (PhI) and Beck’s Depression Inventory – to determine the level of depression. Results. Most often, depression was found in the group of individuals with the index of PhI superiority, who had signs of an extreme desire to compensate for an excessive feeling of inferiority in any way. In particular, about a third (32.35% [21.83–43.86]) of those surveyed had depression, while in the group with no altered self-esteem, the value was 21.36% [17.88–25.05] (p=0.042). The highest median value of scores on the depression scale was also found in the group of individuals with the index of PhI superiority (10 [6; 15] points), p<0.001, compared to respondents with no altered self-esteem. A comparison by gender showed a significantly higher number of women with depression than men; 46.67% [29.40-64.35] of women with the index of PhI superiority had symptoms of depression. Median values of depression scores were also higher in women in all studied subgroups (p<0.05). Conclusions. Research and understanding the phenomenon of inferiority is important for its in-depth study in the context of association with other psychopathological human conditions, especially in the current environment.
{"title":"THE PHENOMENON OF INFERIORITY AND DEPRESSION","authors":"O.R. Berezyuk, O. Filts, V. Hrabchak, R. Sirko","doi":"10.25040/ntsh2023.02.11","DOIUrl":"https://doi.org/10.25040/ntsh2023.02.11","url":null,"abstract":"Introduction. In modern societal conditions, the pathology of the affective sphere occupies a special place among general medical problems. One of the central phenomena, both in depression and in another common affective disorder – mania, is the issue of self-esteem. Aim. To study the presence of depressive disorders depending on the presence of the inferiority phenomenon. Methods of research. The study uses data from the survey of 612 university students of higher education institutions of III and IV accreditation in Lviv, conducted in October – November 2021. Among the respondents, 57.35% (n=351) were men and 42.65% (n=261) were women. The average age of respondents was 20.31±2.99. Respondents filled out questionnaires of the Comparative Feeling of Inferiority Index (CFII) to determine the presence or absence of phenomenon of inferiority (PhI) and Beck’s Depression Inventory – to determine the level of depression. Results. Most often, depression was found in the group of individuals with the index of PhI superiority, who had signs of an extreme desire to compensate for an excessive feeling of inferiority in any way. In particular, about a third (32.35% [21.83–43.86]) of those surveyed had depression, while in the group with no altered self-esteem, the value was 21.36% [17.88–25.05] (p=0.042). The highest median value of scores on the depression scale was also found in the group of individuals with the index of PhI superiority (10 [6; 15] points), p<0.001, compared to respondents with no altered self-esteem. A comparison by gender showed a significantly higher number of women with depression than men; 46.67% [29.40-64.35] of women with the index of PhI superiority had symptoms of depression. Median values of depression scores were also higher in women in all studied subgroups (p<0.05). Conclusions. Research and understanding the phenomenon of inferiority is important for its in-depth study in the context of association with other psychopathological human conditions, especially in the current environment.","PeriodicalId":345961,"journal":{"name":"Proceeding of the Shevchenko Scientific Society. Medical Sciences","volume":"9 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139165119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Yusko, Taras Chendey, Vasyl Lohoida, T. Meleshko, Mykola Rishko, Aleksandra Konic-Ristic, Nadiya Boyko
Introduction: The intestinal microbiome is a diagnostic indicator and therapeutic target for non-communicable diseases. The aim of this work is to test the relationship between arterial stiffness, elasticity, gut microbiota and inflammation markers in the patients with acute coronary syndrome. Methods: Elastic properties of arteries were evaluated by non-invasive arteriography (Tensiomed, Hungary), and intestinal microbiota was studied with the determination of key representatives by routine culturing methodology using biochemical identification kits (LACHEMA, Czech Republic). The level of SIgA and cytokines were detected by enzyme-linked immunosorbent assay (ELISA). The data obtained for the clinical experimental group of patients were compared with the results obtained for the control group. Results: Obtained data demonstrated a strong correlation between intestinal colonization by Enterococcus faecalis and PPbr (r=0.98), AIbr (r=-0.99) and AIao (r=-0.99). Significant correlations were found for Escherichia coli (lac+) and PPbr indicators (r=-0.97), and for Klebsiella oxytoca and SBP (r=-0.95), the systolic area index of the volumetric curve (r=+0.99), and the index of the diastolic area of the volumetric curve (r=-0.99). Indexed areas of the volumetric curve were correlated with colonization of Streptococcus spp. (r=-0.9 and 0.9 for systolic and diastolic area, respectively). Blood pressure correlated with the consentration of Candida spp. (r=0.95). Conclusion: Detected bacteria (E. faecalis, K. oxytoca), pro-inflammatory cytokines, and intestine level of SIgA correlated with increased arterial stiffness and elasticity observed in patients with acute coronary syndromes (ACS) might be used as a rationale for the prevention and individual treatment of ACS in the earlier stages of the disease.
{"title":"GUT MICROBIOME IN ACUTE CORONARY SYNDROME","authors":"L. Yusko, Taras Chendey, Vasyl Lohoida, T. Meleshko, Mykola Rishko, Aleksandra Konic-Ristic, Nadiya Boyko","doi":"10.25040/ntsh2023.02.16","DOIUrl":"https://doi.org/10.25040/ntsh2023.02.16","url":null,"abstract":"Introduction: The intestinal microbiome is a diagnostic indicator and therapeutic target for non-communicable diseases. The aim of this work is to test the relationship between arterial stiffness, elasticity, gut microbiota and inflammation markers in the patients with acute coronary syndrome. Methods: Elastic properties of arteries were evaluated by non-invasive arteriography (Tensiomed, Hungary), and intestinal microbiota was studied with the determination of key representatives by routine culturing methodology using biochemical identification kits (LACHEMA, Czech Republic). The level of SIgA and cytokines were detected by enzyme-linked immunosorbent assay (ELISA). The data obtained for the clinical experimental group of patients were compared with the results obtained for the control group. Results: Obtained data demonstrated a strong correlation between intestinal colonization by Enterococcus faecalis and PPbr (r=0.98), AIbr (r=-0.99) and AIao (r=-0.99). Significant correlations were found for Escherichia coli (lac+) and PPbr indicators (r=-0.97), and for Klebsiella oxytoca and SBP (r=-0.95), the systolic area index of the volumetric curve (r=+0.99), and the index of the diastolic area of the volumetric curve (r=-0.99). Indexed areas of the volumetric curve were correlated with colonization of Streptococcus spp. (r=-0.9 and 0.9 for systolic and diastolic area, respectively). Blood pressure correlated with the consentration of Candida spp. (r=0.95). Conclusion: Detected bacteria (E. faecalis, K. oxytoca), pro-inflammatory cytokines, and intestine level of SIgA correlated with increased arterial stiffness and elasticity observed in patients with acute coronary syndromes (ACS) might be used as a rationale for the prevention and individual treatment of ACS in the earlier stages of the disease.","PeriodicalId":345961,"journal":{"name":"Proceeding of the Shevchenko Scientific Society. Medical Sciences","volume":"119 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139163546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The successful execution of clinical trials for novel anti-rheumatic compounds is increasingly approaching the limits of what can be achieved using radiographic outcomes for the assessment of disease modification. Moreover, there is a growing need for more objective tools to assess joint inflammation, especially for disorders such as axial spondyloarthritis where spinal symptoms are often non-specific and physical findings may be minimal until later stages of disease. The use of MRI to evaluate inflammation in the synovium and bone marrow as well as erosions in peripheral joints of patients with RA and PsA represents a major new advance that should now be routinely implemented in clinical trials of RA. MRI-based scoring systems have been well validated and demonstrate that, for RA, MRI changes after therapeutic intervention may be observed in a month and precede findings on radiography that only become evident after a year. The assessment of disease activity on MRI of the sacroiliac joints and spine using a standardized and well-validated method, such as the SPARCC instruments, is indispensable to the evaluation of efficacy for new agents aimed at the treatment of spondyloarthritis. Further advances include the use of whole-body MRI evaluation to assess inflammation in both the axial and peripheral skeleton as well as sequences that dispense with the requirement for the use of contrast agents, such as gadolinium, and data processing techniques that permit full automation and absolute quantification. This review will discuss how imaging is transforming clinical trials in rheumatic diseases.
新型抗风湿化合物临床试验的成功实施正日益逼近利用放射学结果评估疾病变化所能达到的极限。此外，人们越来越需要更客观的工具来评估关节炎症，尤其是轴性脊柱关节炎等疾病，因为这些疾病的脊柱症状往往没有特异性，而且直到疾病晚期才会有明显的体征。使用核磁共振成像评估RA和PsA患者滑膜和骨髓中的炎症以及外周关节的侵蚀是一项重大的新进展，现在应在RA临床试验中常规应用。基于核磁共振成像的评分系统已得到很好的验证，并证明对于 RA 来说，治疗干预后核磁共振成像的变化可在一个月内观察到，并早于一年后才明显出现的影像学检查结果。使用 SPARCC 等标准化且经过充分验证的方法对骶髂关节和脊柱的 MRI 进行疾病活动性评估，对于评估治疗脊柱关节炎新药的疗效是不可或缺的。进一步的进展包括使用全身 MRI 评估轴向和外周骨骼的炎症，以及无需使用钆等造影剂的序列和允许完全自动化和绝对量化的数据处理技术。本综述将讨论成像技术如何改变风湿性疾病的临床试验。
{"title":"ADVANCES IN IMAGING FOR CLINICAL TRIALS IN RHEUMATIC DISEASES","authors":"Wolodymyr P. Maksymowych","doi":"10.25040/ntsh2023.02.04","DOIUrl":"https://doi.org/10.25040/ntsh2023.02.04","url":null,"abstract":"The successful execution of clinical trials for novel anti-rheumatic compounds is increasingly approaching the limits of what can be achieved using radiographic outcomes for the assessment of disease modification. Moreover, there is a growing need for more objective tools to assess joint inflammation, especially for disorders such as axial spondyloarthritis where spinal symptoms are often non-specific and physical findings may be minimal until later stages of disease. The use of MRI to evaluate inflammation in the synovium and bone marrow as well as erosions in peripheral joints of patients with RA and PsA represents a major new advance that should now be routinely implemented in clinical trials of RA. MRI-based scoring systems have been well validated and demonstrate that, for RA, MRI changes after therapeutic intervention may be observed in a month and precede findings on radiography that only become evident after a year. The assessment of disease activity on MRI of the sacroiliac joints and spine using a standardized and well-validated method, such as the SPARCC instruments, is indispensable to the evaluation of efficacy for new agents aimed at the treatment of spondyloarthritis. Further advances include the use of whole-body MRI evaluation to assess inflammation in both the axial and peripheral skeleton as well as sequences that dispense with the requirement for the use of contrast agents, such as gadolinium, and data processing techniques that permit full automation and absolute quantification. This review will discuss how imaging is transforming clinical trials in rheumatic diseases.","PeriodicalId":345961,"journal":{"name":"Proceeding of the Shevchenko Scientific Society. Medical Sciences","volume":"21 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139164488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pedro Lylyk, A. Netliukh, O. Kobyletskyi, Oleksander Holub, Andrian Sukhanov
Introduction. It is believed that vascular anatomy has a direct influence on the complexity and course of mechanical thrombectomy, and its outcome determines the degree of reperfusion and clinical effect. Aim. To analyze the influence of the curvature of the intracranial arteries and the composition of the thrombus on the results of thrombectomy. Materials and methods. 64 patients who underwent mechanical thrombectomy for acute proximal occlusion of the ICA or MCA were prospectively examined. (44man/20women among them, the age of the patients ranged from 47-89years (67.2±1.2). The study was performed by measuring the ICA-M1 angle on angiograms in direct projection. Angles were compared between patients with successful (mTICI group 2b/3) and unsuccessful (mTICI group 0-2a) reperfusion. The functional result was evaluated according to the mRS scale as positive (0-3) and negative (4-5). Removed thrombi were examined by light microscopy with hematoxylin-eosin and orange-red-blue staining. Results. Among patients of the mTICI 2b/3 group, a larger angle of the ICA-M1 was measured (126.4±2.8°) compared to patients in the mTICI 0-2a group - 107.1±4.9° (p=0.05). Among patients with 1-2 passages, statistically significantly larger ICA-M1 angles were recorded (129.8±3.3°) than among patients with a number of passages >2 (109.2±5,7°, p<0.02). The duration of mechanical thrombectomy was <60min among patients with larger angles of the ICA-M1 (127.6±4.4° vs. 119.6±4.5°) than in patients with long interventions (>60 min) (p<0.05). Successful reperfusion (group mTICI 2b/3) was achieved in 47 (73.4%) patients. A clinically positive result(mRS 0-3) was observed among 37(57.8%) patients. During microscopic examination of thrombi among patient groups mTICI 0/2a, fibrin threads with signs of aging with purple and blue color were present on the periphery (24-48hours). With a favorable outcome of the operation, the coagulated fibrin fibers were stained red (<16hours). Conclusions. With a smaller curvature of the ICA and its branches, and in the presence of "fresh" thrombi, the efficiency of operations increases, and the number of passages and the duration of mechanical thrombectomy decrease. The neurological status of patients at admission correlates with the functional outcome at the time of discharge.
{"title":"THE INFLUENCE OF VESSEL CURVATURE AND THROMBUS COMPOSITION ON THE EFFECTIVENESS AND OUTCOMES OF THROMBECTOMY IN THE CASE OF ACUTE ISCHEMIC STROKE","authors":"Pedro Lylyk, A. Netliukh, O. Kobyletskyi, Oleksander Holub, Andrian Sukhanov","doi":"10.25040/ntsh2023.02.12","DOIUrl":"https://doi.org/10.25040/ntsh2023.02.12","url":null,"abstract":"Introduction. It is believed that vascular anatomy has a direct influence on the complexity and course of mechanical thrombectomy, and its outcome determines the degree of reperfusion and clinical effect. Aim. To analyze the influence of the curvature of the intracranial arteries and the composition of the thrombus on the results of thrombectomy. Materials and methods. 64 patients who underwent mechanical thrombectomy for acute proximal occlusion of the ICA or MCA were prospectively examined. (44man/20women among them, the age of the patients ranged from 47-89years (67.2±1.2). The study was performed by measuring the ICA-M1 angle on angiograms in direct projection. Angles were compared between patients with successful (mTICI group 2b/3) and unsuccessful (mTICI group 0-2a) reperfusion. The functional result was evaluated according to the mRS scale as positive (0-3) and negative (4-5). Removed thrombi were examined by light microscopy with hematoxylin-eosin and orange-red-blue staining. Results. Among patients of the mTICI 2b/3 group, a larger angle of the ICA-M1 was measured (126.4±2.8°) compared to patients in the mTICI 0-2a group - 107.1±4.9° (p=0.05). Among patients with 1-2 passages, statistically significantly larger ICA-M1 angles were recorded (129.8±3.3°) than among patients with a number of passages >2 (109.2±5,7°, p<0.02). The duration of mechanical thrombectomy was <60min among patients with larger angles of the ICA-M1 (127.6±4.4° vs. 119.6±4.5°) than in patients with long interventions (>60 min) (p<0.05). Successful reperfusion (group mTICI 2b/3) was achieved in 47 (73.4%) patients. A clinically positive result(mRS 0-3) was observed among 37(57.8%) patients. During microscopic examination of thrombi among patient groups mTICI 0/2a, fibrin threads with signs of aging with purple and blue color were present on the periphery (24-48hours). With a favorable outcome of the operation, the coagulated fibrin fibers were stained red (<16hours). Conclusions. With a smaller curvature of the ICA and its branches, and in the presence of \"fresh\" thrombi, the efficiency of operations increases, and the number of passages and the duration of mechanical thrombectomy decrease. The neurological status of patients at admission correlates with the functional outcome at the time of discharge.","PeriodicalId":345961,"journal":{"name":"Proceeding of the Shevchenko Scientific Society. Medical Sciences","volume":"7 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139164947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We are deeply saddened to inform that on August 12, Yarema Illich Tomashevskyi, a distinguished professor of the Danylo Halytsky Lviv National Medical University, passed away at the age of 94. Professor Tomashevskyi was born on December 3, 1929, in the village of Stetseva in Pokuttia area. In 1953, he graduated with honors from Lviv Medical Institute and then studied in the clinical residency program for internal medicine from 1953 to 1955. In the following three years, he chaired the therapeutic departments of Kamianka-Buzka District Hospital and the 4th Hospital in Lviv. In 1958, he commenced employment as an assistant at Lviv Medical Institute and was subsequently promoted to Associate Professor of therapeutic departments. He started and chaired the Department of Endocrinology and Clinical Pharmacology, where he worked for 44 years, from 1978 to 2022. Yarema Illich created and developed the Lviv endocrinological school, the regional endocrinological dispensary, and headed the regional association of endocrinologists. He was a member of the Ukrainian Scientific Society of Endocrinologists. Professor Tomashevskyi’s scientific and research endeavors are centered around the issues of cardiology, rheumatology, gastroenterology, balneotherapy, clinical vitaminology, and endocrinology. He deemed the prevention of diseases to be of paramount significance. He founded the Academy of Preventive Medicine at the Shevchenko Scientific Society. He has worked on programs aimed at preventing iodine deficiency disorders and early diagnosis of diabetes, which he diligently implemented in practice. Professor Tomashevskyi is the author and co-author of over 350 publications, including seven monographs and textbooks and many methodological recommendations. Under his leadership, two doctoral and 15 candidate theses were successfully defended. The professor’s professional activities included membership in the Ukrainian Medical Association, the European Association for the Study of Diabetes, and editorial boards of the journals “Endocrinology” and “International Endocrinology Journal.” He also contributed to the compilation of scientific works “The Phenomenon of Human. Healthy lifestyle,” “Medical Collection of The Shevchenko Scientific Society.” He was a full member of the Shevchenko Scientific Society and headed the Medical Commission of the SSS for several years. He was respected and known in the medical scientific community of Ukraine. In 1985, Yarema Illich was awarded the badge “Excellence in Healthcare.” Professor Yarema Tomashevskyi was an excellent teacher and lecturer, a highly qualified doctor who was loved and respected by students, colleagues, and patients. He was a respected citizen. The professor led a respectable life full of tireless work and care. His favorite sayings from the ancient sacraments, which he steadfastly adhered to, were: “Rush to do good, as human life is fleeting; do everything in moderation; and never express anger.” He was always
{"title":"IN MEMORY OF PROFESSOR YAREMA TOMASHEVSKYI – SCIENTIST, DOCTOR AND TEACHER","authors":"V. Chopyak","doi":"10.25040/ntsh2023.02.22","DOIUrl":"https://doi.org/10.25040/ntsh2023.02.22","url":null,"abstract":"We are deeply saddened to inform that on August 12, Yarema Illich Tomashevskyi, a distinguished professor of the Danylo Halytsky Lviv National Medical University, passed away at the age of 94. Professor Tomashevskyi was born on December 3, 1929, in the village of Stetseva in Pokuttia area. In 1953, he graduated with honors from Lviv Medical Institute and then studied in the clinical residency program for internal medicine from 1953 to 1955. In the following three years, he chaired the therapeutic departments of Kamianka-Buzka District Hospital and the 4th Hospital in Lviv. In 1958, he commenced employment as an assistant at Lviv Medical Institute and was subsequently promoted to Associate Professor of therapeutic departments. He started and chaired the Department of Endocrinology and Clinical Pharmacology, where he worked for 44 years, from 1978 to 2022. Yarema Illich created and developed the Lviv endocrinological school, the regional endocrinological dispensary, and headed the regional association of endocrinologists. He was a member of the Ukrainian Scientific Society of Endocrinologists. Professor Tomashevskyi’s scientific and research endeavors are centered around the issues of cardiology, rheumatology, gastroenterology, balneotherapy, clinical vitaminology, and endocrinology. He deemed the prevention of diseases to be of paramount significance. He founded the Academy of Preventive Medicine at the Shevchenko Scientific Society. He has worked on programs aimed at preventing iodine deficiency disorders and early diagnosis of diabetes, which he diligently implemented in practice. Professor Tomashevskyi is the author and co-author of over 350 publications, including seven monographs and textbooks and many methodological recommendations. Under his leadership, two doctoral and 15 candidate theses were successfully defended. The professor’s professional activities included membership in the Ukrainian Medical Association, the European Association for the Study of Diabetes, and editorial boards of the journals “Endocrinology” and “International Endocrinology Journal.” He also contributed to the compilation of scientific works “The Phenomenon of Human. Healthy lifestyle,” “Medical Collection of The Shevchenko Scientific Society.” He was a full member of the Shevchenko Scientific Society and headed the Medical Commission of the SSS for several years. He was respected and known in the medical scientific community of Ukraine. In 1985, Yarema Illich was awarded the badge “Excellence in Healthcare.” Professor Yarema Tomashevskyi was an excellent teacher and lecturer, a highly qualified doctor who was loved and respected by students, colleagues, and patients. He was a respected citizen. The professor led a respectable life full of tireless work and care. His favorite sayings from the ancient sacraments, which he steadfastly adhered to, were: “Rush to do good, as human life is fleeting; do everything in moderation; and never express anger.” He was always","PeriodicalId":345961,"journal":{"name":"Proceeding of the Shevchenko Scientific Society. Medical Sciences","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139164964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We present a clinical case of the association of CCHB and HLHS in a newborn. The etiological relation between these two pathologies is unclear. According to the literature data, 70–90% of isolated CCHB are caused by maternal anti-Ro and anti-La antibodies, which cross the placenta and lead to fibrosis of the AV node or occur due to genetic defects, such as mutations in the SCN5A gene. Other theories suggest that compromised coronary blood flow in late fetal life could be a cause of CCHB, as the AV-node artery is the first and longest inferior septal branch of the right (90%) or left (10%) coronary artery, arising from U- or V-shaped segment of the corresponding artery at the level of the crux cordis. In our case, the level of maternal auto-antibody titers was unknown. It is possible that the heart block could be linked to the structural heart defect – HLHS, which could be the cause of hypoperfusion of AV node in fetal life. Only two similar cases of such combination are described in the literature.
我们介绍了一例新生儿合并 CCHB 和 HLHS 的临床病例。这两种病症之间的病因关系尚不清楚。根据文献资料，70%-90%的孤立性 CCHB 是由母体的抗 Ro 和抗 La 抗体穿过胎盘导致房室结纤维化引起的，或者是由于遗传缺陷（如 SCN5A 基因突变）引起的。其他理论认为，胎儿晚期冠状动脉血流受损可能是导致 CCHB 的原因之一，因为房室结动脉是右冠状动脉（90%）或左冠状动脉（10%）的最先和最长的下隔分支，起源于相应动脉在嵴水平的 U 形或 V 形段。在我们的病例中，母体自身抗体滴度水平不明。心脏传导阻滞可能与结构性心脏缺陷（HLHS）有关，HLHS 可能是导致胎儿期房室结灌注不足的原因。文献中仅有两例类似病例。
{"title":"HYPOPLASTIC LEFT HEART SYNDROME AND COMPLETE CONGENITAL HEART BLOCK IN A NEWBORN, A RARE ASSOCIATION","authors":"A. Malska, Olha Kuryliak, Martha Telishevska","doi":"10.25040/ntsh2023.02.19","DOIUrl":"https://doi.org/10.25040/ntsh2023.02.19","url":null,"abstract":"We present a clinical case of the association of CCHB and HLHS in a newborn. The etiological relation between these two pathologies is unclear. According to the literature data, 70–90% of isolated CCHB are caused by maternal anti-Ro and anti-La antibodies, which cross the placenta and lead to fibrosis of the AV node or occur due to genetic defects, such as mutations in the SCN5A gene. Other theories suggest that compromised coronary blood flow in late fetal life could be a cause of CCHB, as the AV-node artery is the first and longest inferior septal branch of the right (90%) or left (10%) coronary artery, arising from U- or V-shaped segment of the corresponding artery at the level of the crux cordis. In our case, the level of maternal auto-antibody titers was unknown. It is possible that the heart block could be linked to the structural heart defect – HLHS, which could be the cause of hypoperfusion of AV node in fetal life. Only two similar cases of such combination are described in the literature.","PeriodicalId":345961,"journal":{"name":"Proceeding of the Shevchenko Scientific Society. Medical Sciences","volume":"24 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139165127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Duve, Robert Olszewski, S. Shkrobot, Natalia Shalabay
The aim: To investigate potential associations between the C3953T polymorphic variant of the interleukin-one beta (IL1β) gene and clinical-neurological, neuroimaging, hemodynamic characteristics, as well as cognitive dysfunction in patients with post-infectious encephalopathy (PIE). Materials and methods: A total of 128 patients with post-infectious encephalopathy (PIE) who were receiving inpatient treatment in the neurological departments of the Communal Non-commercial Enterprise “Ternopil Regional Clinical Psychoneurological Hospital” of Ternopil Regional Council,” Ternopil, Ukraine, were examined and included in the retrospective analysis in 2021–2022. The molecular-genetic testing was performed for 26 patients in the molecular genetics laboratory of the State Institution “Reference Centre for Molecular Diagnostics of the Ministry of Health of Ukraine,” Kyiv. The control group consisted of 12 people, who were representative in age and gender. Statistical processing of the results was performed using the STATISTICA 10.0 software. Results: Analysis of the dependence of neuroimaging changes on the frequency of genotypes of the C3953T polymorphic variant of the IL1β gene in patients with PIE showed a significant relationship between their frequency distribution and the presence/absence of gliosis phenomena (p=0.009). Thus, gliosis was detected in all carriers of the T/T genotype C3953T polymorphic variant of the IL1β gene. Analyzing the dependence of changes obtained during the transcranial Doppler ultrasound scanning of cerebral vessels on the polymorphic variant C3953T of the IL1β gene in patients with PIE, all carriers of the T/T genotype were diagnosed with angiospasm (p=0.038) and vertebrobasilar insufficiency (p=0.010). Conclusions: Results suggest the reasonability of further researching the interaction between IL1β and glial cells and changes in the cognitive functioning of cytokine genotypes with larger sample sizes that may help explain the pathophysiological mechanisms leading to cognitive impairment in patients with PIE.
{"title":"THE STUDY OF ASSOCIATIONS BETWEEN IL1Β C3953T GENE POLYMORPHISM AND CLINICAL-NEUROLOGICAL, NEUROIMAGING, HEMODYNAMIC CHARACTERISTICS AND COGNITIVE DYSFUNCTION IN PATIENTS WITH POST-INFECTIOUS ENCEPHALOPATHY","authors":"K. Duve, Robert Olszewski, S. Shkrobot, Natalia Shalabay","doi":"10.25040/ntsh2023.02.09","DOIUrl":"https://doi.org/10.25040/ntsh2023.02.09","url":null,"abstract":"The aim: To investigate potential associations between the C3953T polymorphic variant of the interleukin-one beta (IL1β) gene and clinical-neurological, neuroimaging, hemodynamic characteristics, as well as cognitive dysfunction in patients with post-infectious encephalopathy (PIE). Materials and methods: A total of 128 patients with post-infectious encephalopathy (PIE) who were receiving inpatient treatment in the neurological departments of the Communal Non-commercial Enterprise “Ternopil Regional Clinical Psychoneurological Hospital” of Ternopil Regional Council,” Ternopil, Ukraine, were examined and included in the retrospective analysis in 2021–2022. The molecular-genetic testing was performed for 26 patients in the molecular genetics laboratory of the State Institution “Reference Centre for Molecular Diagnostics of the Ministry of Health of Ukraine,” Kyiv. The control group consisted of 12 people, who were representative in age and gender. Statistical processing of the results was performed using the STATISTICA 10.0 software. Results: Analysis of the dependence of neuroimaging changes on the frequency of genotypes of the C3953T polymorphic variant of the IL1β gene in patients with PIE showed a significant relationship between their frequency distribution and the presence/absence of gliosis phenomena (p=0.009). Thus, gliosis was detected in all carriers of the T/T genotype C3953T polymorphic variant of the IL1β gene. Analyzing the dependence of changes obtained during the transcranial Doppler ultrasound scanning of cerebral vessels on the polymorphic variant C3953T of the IL1β gene in patients with PIE, all carriers of the T/T genotype were diagnosed with angiospasm (p=0.038) and vertebrobasilar insufficiency (p=0.010). Conclusions: Results suggest the reasonability of further researching the interaction between IL1β and glial cells and changes in the cognitive functioning of cytokine genotypes with larger sample sizes that may help explain the pathophysiological mechanisms leading to cognitive impairment in patients with PIE.","PeriodicalId":345961,"journal":{"name":"Proceeding of the Shevchenko Scientific Society. Medical Sciences","volume":"17 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139165009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
For at least a century, an often-debated topic is what is of primary importance to make breakthrough in biomedical research: originality/creativity or sophisticated methods/equipment. We present here a short historical overview arguing about the importance of creativity, originality, and persistence. Namely, the best living example of this is the 2023 Nobel Prize in Physiology or Medicine awarded to Drs. Katalin Kariko and Drew Weissman for the invention and development of mRNA-based vaccine against COVID-19. Katalin Kariko had a life-long obsession to use mRNA for cancer therapy, but when the structure of SARS-CoV-2 was announced, she shifted her interest to develop an mRNA-based vaccine against the new virus. But since the mRNA molecule is notoriously unstable and easily degraded if injected intracellularly, she teamed up with Dr. Weissman who was working on techniques to deliver mRNA molecules intracellularly. This creative teamwork with original ideas of vaccine development illustrates what other creative scientists, like Alexander Flemming, Hans Selye, Leon Popielski and James Black discovered in their fields. The sad part of the story is that only two of these scientists got the Nobel Prize.
{"title":"CREATIVITY AND ORIGINALITY ARE KEY ELEMENTS IN MEDICAL RESEARCH: RECENT ILLUSTRATION BY THE 2023 NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE TO KATALIN KARIKO AND DREW WEISSMAN","authors":"Sandor Szabo, Oksana Zayachkivska","doi":"10.25040/ntsh2023.02.20","DOIUrl":"https://doi.org/10.25040/ntsh2023.02.20","url":null,"abstract":"For at least a century, an often-debated topic is what is of primary importance to make breakthrough in biomedical research: originality/creativity or sophisticated methods/equipment. We present here a short historical overview arguing about the importance of creativity, originality, and persistence. Namely, the best living example of this is the 2023 Nobel Prize in Physiology or Medicine awarded to Drs. Katalin Kariko and Drew Weissman for the invention and development of mRNA-based vaccine against COVID-19. Katalin Kariko had a life-long obsession to use mRNA for cancer therapy, but when the structure of SARS-CoV-2 was announced, she shifted her interest to develop an mRNA-based vaccine against the new virus. But since the mRNA molecule is notoriously unstable and easily degraded if injected intracellularly, she teamed up with Dr. Weissman who was working on techniques to deliver mRNA molecules intracellularly. This creative teamwork with original ideas of vaccine development illustrates what other creative scientists, like Alexander Flemming, Hans Selye, Leon Popielski and James Black discovered in their fields. The sad part of the story is that only two of these scientists got the Nobel Prize.","PeriodicalId":345961,"journal":{"name":"Proceeding of the Shevchenko Scientific Society. Medical Sciences","volume":"6 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139165137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marta Nadragа, Roman Holyk, V. Lonchyna, Melania-Iryna Nadraga
The year 2022 marks the 100th anniversary of Bohdan Yevhen Nadragа’s birth (1922–2018): A medical doctor, an active member of the SHEVCHENKO SCIENTIFIC SOCIETY (SSS) and the UKRAINIAN MEDICAL ASSOCIATION (UMA), and one of the promoters of the restoration of the traditions of Galician medicine. The purpose of the article is to show the figure of Bohdan Yevhen Nadragа in the context of the history of medicine, scientific and professional interests, and reader preferences based on his own memories and the collective memory of him as a doctor. Bohdan-Yevhen Nadragа was born on March 24, 1922, in Lviv, in the family of lawyer Oleksandr Nadragа and one of the first Galician Ukrainian doctors, Theodosia Tuna-Nadragа. The father passed on a keen sense of moral and legal justice to his son, while the mother – an interest in medicine. His love of medicine and biology was facilitated by his matriculation at the Lviv Academic Gymnasium in the conditions of interwar Poland. After graduating from the gymnasium, B. Nadragа entered Lviv State Medical Institute, where he studied specialized medical courses organized by the German occupation authorities from 1941 to 1944 and graduated in 1945. Here, he entered postgraduate studies at the Department of Normal Physiology, but in October 1947, he was deported to Anzhero-Sudzhensk, Kemerovo Region (Siberia) with his family. There, he worked with his mother, first as a state farm worker and then as a district pediatrician. Only in 1959 was he able to return to Galicia, where he worked as a doctor and was the chief doctor (1966–1983) at Sambir City Children’s Hospital. In 1993, he returned to his native Lviv, where he began working in the methodological office of Lviv Regional Children’s Clinical Hospital (1993-2012). During 1993–1995, he served as the director of the Hospital named after Metropolitan Andrey Sheptytskyi (“Narodna Lichnytsia”), became a member of the board of the restored UMA, joined the work of the medical commission of the Shevchenko Scientific Society, and was the author and editor of many publications of these societies. As the head of the Council of Medical Ethics at UMA, he became one of the authoritative participants in ethical discussions in the medical environment in 1990–2000; he was interested in the history of Lviv medicine and promoted the image of Lviv and Galicia. Respected by everyone as a model doctor and patriot, he passed away on September 28, 2018, at the age of almost 97. The activities of Bohdan Yevhen Nadragа are part of the history of Lviv and Galicia and Galician medicine, in particular pediatrics, to which he devoted his entire professional life.
{"title":"BOHDAN YEVHEN NADRAGА – A DOCTOR BY DESTINY’S CALLING","authors":"Marta Nadragа, Roman Holyk, V. Lonchyna, Melania-Iryna Nadraga","doi":"10.25040/ntsh2023.02.21","DOIUrl":"https://doi.org/10.25040/ntsh2023.02.21","url":null,"abstract":"The year 2022 marks the 100th anniversary of Bohdan Yevhen Nadragа’s birth (1922–2018): A medical doctor, an active member of the SHEVCHENKO SCIENTIFIC SOCIETY (SSS) and the UKRAINIAN MEDICAL ASSOCIATION (UMA), and one of the promoters of the restoration of the traditions of Galician medicine. The purpose of the article is to show the figure of Bohdan Yevhen Nadragа in the context of the history of medicine, scientific and professional interests, and reader preferences based on his own memories and the collective memory of him as a doctor. Bohdan-Yevhen Nadragа was born on March 24, 1922, in Lviv, in the family of lawyer Oleksandr Nadragа and one of the first Galician Ukrainian doctors, Theodosia Tuna-Nadragа. The father passed on a keen sense of moral and legal justice to his son, while the mother – an interest in medicine. His love of medicine and biology was facilitated by his matriculation at the Lviv Academic Gymnasium in the conditions of interwar Poland. After graduating from the gymnasium, B. Nadragа entered Lviv State Medical Institute, where he studied specialized medical courses organized by the German occupation authorities from 1941 to 1944 and graduated in 1945. Here, he entered postgraduate studies at the Department of Normal Physiology, but in October 1947, he was deported to Anzhero-Sudzhensk, Kemerovo Region (Siberia) with his family. There, he worked with his mother, first as a state farm worker and then as a district pediatrician. Only in 1959 was he able to return to Galicia, where he worked as a doctor and was the chief doctor (1966–1983) at Sambir City Children’s Hospital. In 1993, he returned to his native Lviv, where he began working in the methodological office of Lviv Regional Children’s Clinical Hospital (1993-2012). During 1993–1995, he served as the director of the Hospital named after Metropolitan Andrey Sheptytskyi (“Narodna Lichnytsia”), became a member of the board of the restored UMA, joined the work of the medical commission of the Shevchenko Scientific Society, and was the author and editor of many publications of these societies. As the head of the Council of Medical Ethics at UMA, he became one of the authoritative participants in ethical discussions in the medical environment in 1990–2000; he was interested in the history of Lviv medicine and promoted the image of Lviv and Galicia. Respected by everyone as a model doctor and patriot, he passed away on September 28, 2018, at the age of almost 97. The activities of Bohdan Yevhen Nadragа are part of the history of Lviv and Galicia and Galician medicine, in particular pediatrics, to which he devoted his entire professional life.","PeriodicalId":345961,"journal":{"name":"Proceeding of the Shevchenko Scientific Society. Medical Sciences","volume":"27 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139164533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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