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Functional (psychogenic) seizures are associated with thyroid disorders 功能性(心因性)癫痫发作与甲状腺疾病有关
Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-04-01 DOI: 10.4103/hm.hm_37_21
A. Asadi-Pooya, Mohsen Farazdaghi
Objective: We investigated medical comorbidities in patients with functional seizures (FS) and those with epilepsy (idiopathic generalized epilepsies [IGEs] or temporal lobe epilepsy [TLE]). We hypothesized that the nature of medical comorbidities differs between these three groups. This might be helpful to postulate on the pathophysiology of FS. Materials and Methods: In a retrospective study, all adult patients with a diagnosis of IGE, TLE, or FS were recruited at the outpatient epilepsy clinic at Shiraz University of Medical Sciences, Iran, from 2008 until 2020. The three groups of patients were matched with regard to their age. Age, sex, and medical comorbidities were registered routinely for all patients at the time of the first visit. Results: Nine hundred and sixty-six patients were studied (254 patients with IGE, 467 persons with TLE, and 245 individuals with FS). The groups differed significantly with regard to having medical comorbidities. The most striking difference was comorbid thyroid disorders; this was more common among patients with FS. The diagnosis of FS was independently significantly associated with thyroid disorder comorbidity (odds ratio: 2.77, 95% confidence interval: 1.06–7.23; P = 0.038). Conclusion: Thyroid disorders are significantly associated with FS. We can make the following suggestions to advance the field: a. It is necessary to reproduce this observation in larger multicenter studies; b. We recommend to evaluate thyroid function in all patients with FS; c. It might be helpful to design clinical trials to investigate whether correction of any clinical or subclinical thyroid disorders changes the treatment outcome in patients with FS.
目的:探讨功能性癫痫发作(FS)和癫痫(特发性全身性癫痫[IGEs]或颞叶癫痫[TLE])患者的合并症。我们假设,医学合并症的性质在这三组之间有所不同。这可能有助于对FS的病理生理进行推测。材料和方法:在一项回顾性研究中,从2008年到2020年,在伊朗设拉子医科大学门诊癫痫诊所招募了所有诊断为IGE、TLE或FS的成年患者。这三组患者的年龄是相匹配的。在第一次就诊时,对所有患者的年龄、性别和合并症进行常规登记。结果:共纳入966例患者(254例IGE, 467例TLE, 245例FS)。两组在医疗合并症方面存在显著差异。最显著的差异是共病性甲状腺疾病;这在FS患者中更为常见。FS的诊断与甲状腺疾病合并症独立显著相关(优势比:2.77,95%可信区间:1.06-7.23;P = 0.038)。结论:甲状腺功能障碍与FS有显著相关性。我们可以提出以下建议来推进该领域:a.有必要在更大的多中心研究中重现这一观察结果;b.我们建议对所有FS患者进行甲状腺功能评估;c.可能有助于设计临床试验来研究纠正任何临床或亚临床甲状腺疾病是否会改变FS患者的治疗结果。
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引用次数: 0
An unusual case of dense mitral annular calcification in a young with plethora of mitral annular premature ventricular complexes 一例罕见的年轻人二尖瓣环致密钙化伴二尖瓣环早搏复合体过多
Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-04-01 DOI: 10.4103/hm.hm_57_21
Debasish Das, Tutan Das, Subhash R. Pramanik
We report a rare case of dense mitral annular calcification in a 26-year-old male presenting with recurrent palpitation for the last year with a plethora of mitral annular premature ventricular complexes (PVCs). PVCs had right bundle branch block morphology, were notched in inferior leads with negative QRS complexes in aVL suggestive of likely origin from the lateral mitral annulus. Patients with PVCs from mitral annulus are usually advised to undergo cardiac magnetic resonance imaging to localize the site of subtle mitral annular calcification and plan subsequent delivery of radiofrequency lesions at the same site during radiofrequency ablation. Dense calcification of the lateral mitral annulus is extremely rare to encounter in such a young age of below 30 years without the presence of any predisposing risk factors for calcification. Our case is the first illustration of dense mitral annular calcification secondary to the plethora of mitral annular PVCs in a symptomatic young person below the age of 30 years. PVCs-induced excessive local excursion with wear and tear phenomenon and secondary dystrophic calcification may be the plausible explanation behind this interesting presentation.
我们报告一个罕见的病例密集的二尖瓣环钙化在一个26岁的男性表现为反复心悸,为去年过多的二尖瓣环早衰心室复核(pvc)。室性早搏呈右束支闭塞形态,下导联呈缺口状,aVL QRS复合物阴性,提示可能起源于二尖瓣外侧环。来自二尖瓣环的室性早搏患者通常建议进行心脏磁共振成像以定位细微二尖瓣环钙化的部位,并计划随后在射频消融过程中在同一部位进行射频病灶的输送。二尖瓣外侧环致密钙化在30岁以下的年轻人中是非常罕见的,没有任何钙化的易感危险因素。我们的病例是一例30岁以下有症状的年轻人二尖瓣环钙化的第一例,继发于二尖瓣环室性早衰过多。聚氯乙烯引起的过度局部偏移与磨损现象和继发性营养不良钙化可能是这种有趣表现背后的合理解释。
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引用次数: 0
Anxiety in individuals with cardiovascular diseases: A narrative review and expert opinion 心血管疾病患者的焦虑:叙述回顾和专家意见
Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-04-01 DOI: 10.4103/hm.hm_5_22
Weiguang Jiang
Anxiety is a commonly prevalent mental problem in patients with cardiovascular diseases (CVD), but its significance and clinical management have been neglected until recently. Similar to depression, anxiety has been demonstrated to be prevalent and hinging the quality of life and optimal outcome of patients with CVD. Although research evidence is still limited, clinical management for depression may be adopted for the care of anxiety in patients with CVD. Special attention needs to be paid when diagnosing anxiety disorder in patients with CVD because the fear may be a normal reaction of these patients and anxiety may manifest somatically.
焦虑是心血管疾病(CVD)患者普遍存在的心理问题,但其意义和临床管理一直被忽视。与抑郁症类似,焦虑已被证明是普遍的,并关系到CVD患者的生活质量和最佳结果。尽管研究证据仍然有限,但抑郁症的临床治疗可以用于治疗CVD患者的焦虑。在诊断CVD患者的焦虑症时需要特别注意,因为恐惧可能是这些患者的正常反应,焦虑可能在身体上表现出来。
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引用次数: 0
Trends and outcomes of coronary artery bypass grafting in patients with major depressive disorder: A perspective from the national inpatient sample 重度抑郁症患者冠状动脉旁路移植术的趋势和结果:来自全国住院患者样本的视角
Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-04-01 DOI: 10.4103/hm.hm_62_21
Andrew M Del Re, Krissia M. Rivera Perla, Ghazal Aghagoli, K. Bellam, F. Sellke, A. Ehsan
Purpose: Coronary artery disease is a major cause of morbidity and mortality in the United States, representing the highest proportion of deaths due to cardiovascular disease. Treatment of coronary artery disease ranges from prevention to intervention, with the latter warranting a decision between surgical versus percutaneous revascularization. Medical optimization before coronary artery bypass grafting (CABG) is an important step in the care continuum. While the optimization of many risk factors such as smoking has been studied extensively, the inclusion of mental health conditions in preoperative health assessment is not yet standard of care. Major depressive disorder (MDD) is the most prevalent mental health disorder and has been shown to affect physiological processes that are critical in recovery after cardiac surgery. Methods: We queried the national inpatient sample from 2000 to 2017 for patients ≥18 years undergoing CABG with and without MDD. Patients who left against medical advice were excluded. Patients with a diagnosis of MDD were compared against those without. Our primary outcomes were in-hospital mortality, favorable discharge (home or home with services), and length of stay. Multivariable models were used for the various outcomes and each model adjusted for confounding variables. Results: A total of 2,988,997 met clinical criteria for inclusion including 108,782 with an MDD diagnosis. Most patients were male (n = 2,135,804, 71.46%), White (n = 2,417,216, 80.87%), and the average age was 66.3 years (standard deviation = 10.8 years). After adjustment, patients with a diagnosis of MDD were found to have lower odds of in-hospital mortality (odds ratio [OR] [95% confidence interval {CI}] 0.64 [0.56–0.73], P < 0.001) and had decreased odds of home discharge (OR = 0.66 [0.63–0.69], P < 0.001) after CABG. Overall, length of stay was similar between the groups, with MDD patients having a slightly longer length of stay (β-coefficient = 1.03 [1.03–1.04], P < 0.001). Patients with a diagnosis of MDD were also found to have lower odds of acute kidney injury (OR = 0.70 [0.61–0.81], P < 0.001), cardiogenic shock (OR = 0.75 [0.68–0.83], P < 0.001), infection (OR = 0.78 [0.69–0.89], P < 0.001), transient ischemic attack/stroke (OR = 0.75 [0.63–0.89], P = 0.001), acute liver injury (OR = 0.45 [0.34–0.61], P < 0.001), and acute limb ischemia (OR = 0.57 [0.40–0.82], P = 0.003). Conclusions: Patients with a diagnosis of MDD have decreased odds of postoperative morbidity and mortality after CABG in addition to having lower odds of home discharge. The present study suggests a need for prospective investigations on the impact of MDD diagnosis and outcomes after CABG to further understand this relationship.
目的:冠状动脉疾病是美国发病率和死亡率的主要原因,在心血管疾病死亡中所占比例最高。冠状动脉疾病的治疗范围从预防到干预,后者需要在手术与经皮血管重建术之间做出决定。冠状动脉旁路移植术(CABG)前的医疗优化是护理连续性的重要步骤。虽然对吸烟等许多危险因素的优化已经进行了广泛的研究,但在术前健康评估中纳入心理健康状况尚未成为标准的护理。重度抑郁症(MDD)是最普遍的精神健康障碍,已被证明会影响心脏手术后恢复的关键生理过程。方法:我们查询了2000年至2017年全国住院患者样本,包括≥18岁的伴有和不伴有MDD的CABG患者。不遵医嘱离开的患者被排除在外。将诊断为重度抑郁症的患者与未诊断为重度抑郁症的患者进行比较。我们的主要结局是住院死亡率、出院情况良好(在家或有服务的在家)和住院时间。各种结果采用多变量模型,每个模型对混杂变量进行调整。结果:共有298,997人符合临床入选标准,其中108,782人诊断为重度抑郁症。患者以男性(n = 2135804, 71.46%)、白人(n = 2417216, 80.87%)居多,平均年龄66.3岁(标准差= 10.8岁)。调整后发现,诊断为重度抑郁症的患者在CABG后住院死亡率较低(比值比[OR][95%可信区间{CI}] 0.64 [0.56-0.73], P < 0.001),出院率较低(OR = 0.66 [0.63-0.69], P < 0.001)。总体而言,两组间的住院时间相似,重度抑郁症患者的住院时间稍长(β-系数= 1.03 [1.03 - 1.04],P < 0.001)。诊断为MDD的患者发生急性肾损伤(OR = 0.70 [0.61-0.81], P < 0.001)、心源性休克(OR = 0.75 [0.68-0.83], P < 0.001)、感染(OR = 0.78 [0.69-0.89], P < 0.001)、短暂性脑缺血发作/卒中(OR = 0.75 [0.63-0.89], P = 0.001)、急性肝损伤(OR = 0.45 [0.34-0.61], P < 0.001)、急性肢体缺血(OR = 0.57 [0.40-0.82], P = 0.003)的几率也较低。结论:诊断为重度抑郁症的患者在CABG术后发病率和死亡率以及出院率均较低。目前的研究表明,有必要对冠脉搭桥后重度抑郁症诊断和预后的影响进行前瞻性调查,以进一步了解这种关系。
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引用次数: 2
Impact of atrial fibrillation on the severity, progress, and disability of the ischemic stroke patients 房颤对缺血性脑卒中患者严重程度、进展和残疾的影响
Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-01-01 DOI: 10.4103/hm.hm_27_21
Kiriaki Mavromoustakou, I. Doundoulakis, S. Soulaidopoulos, P. Arsenos, A. Laina, S. Sideris, P. Dilaveris, D. Tsiachris, A. Kordalis, K. Tsioufis, K. Gatzoulis
Background and Aim: The association of atrial fibrillation (AF) with the ischemic stroke has emerged as an area of clinical research. The purpose of the present study is to investigate possible correlations between the severity, progress, and outcome of ischemic stroke and the presence of AF. Materials and Methods and Results: The clinical assessment of patients was based on the neurological status at the time of diagnosis utilizing the National Institutes of Health Stroke Scale (NIHSS), the neurological semiology during hospitalization (improvement, deterioration, and without differentiation), and the final outcome at the end of the treatment optimizing the modified Rankin scale (mRS). A total of 344 patients diagnosed with an ischemic stroke were enrolled in the study. The presence of AF was found to be associated with higher severity, poorer progress, and more adverse clinical outcomes of the ischemic stroke. Furthermore, a lower frequency of transient ischemic attacks was observed in patients with AF. Finally, patients with AF presented higher incidence of middle cerebral artery occlusion and were more frequently found with a lesion on the left brain hemisphere. Conclusion: AF was found to be highly associated with higher severity and poorer prognosis of ischemic strokes, independently from the presence of other cardiovascular risk factors.
背景和目的:心房颤动(AF)和缺血性卒中的相关性已成为临床研究的一个领域。本研究的目的是调查缺血性卒中的严重程度、进展和结果与AF的存在之间的可能相关性。材料、方法和结果:患者的临床评估基于诊断时的神经状态,采用美国国立卫生研究院卒中量表(NIHSS),住院期间的神经症状学(改善、恶化和无分化),以及优化改良兰金量表(mRS)的治疗结束时的最终结果。共有344名被诊断为缺血性中风的患者参与了这项研究。研究发现,房颤的存在与缺血性中风的严重程度更高、进展更差和更不利的临床结果有关。此外,在AF患者中观察到短暂性脑缺血发作的频率较低。最后,AF患者大脑中动脉闭塞的发生率较高,并且更频繁地发现左大脑半球有病变。结论:房颤与缺血性中风的严重程度和预后密切相关,与其他心血管危险因素无关。
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引用次数: 3
Maternal depression and preeclampsia: Effects on the maternal and offspring's mental and physical health 母亲抑郁和子痫前期:对母亲和后代身心健康的影响
Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-01-01 DOI: 10.4103/hm.hm_41_21
D. Lin, Yequn Chen
Prenatal depression and preeclampsia (PE) are well-known risk factors of maternal and fetal mortality and morbidity. In recent years, there are emerging evidence suggesting that prenatal depression and PE could be environmental risk factors for several neurodevelopment disorders of offspring. Prenatal depression and PE were also found to be risk factors of each other. At present, the mechanism (s) of how prenatal depression and PE affect one another and their roles in the development of maternal and fetal adverse outcomes are uncertain. In this review, we outline the most recent clinical studies on the effects of prenatal depression and PE on the neurodevelopmental outcomes of offspring, as well as the plausible mechanism(s) of how these two maternal conditions affect each other and their roles in the neurodevelopment of offspring, including inflammation, oxidative stress, and maternal immune activation. We postulate that the overproduction of pro-inflammatory cytokines and increased cortisol levels in maternal depression can alter fetal neurodevelopment, and the autonomic nervous system dysfunction caused by maternal depression may accelerate heart rate and elevate blood pressure in mothers. Similarly, in PE, the elevated inflammation and exaggerated oxidative stress in the mothers, placenta, and fetus could negatively affect maternal depression on and impair the neurodevelopment of offspring. Further studies are needed to examine the combined effects of prenatal depression and PE on the health outcomes of mothers and offspring, to explore the mechanism of maternal depression in the development of PE and to investigate their roles in the neurodevelopment of offspring.
产前抑郁症和先兆子痫(PE)是众所周知的孕产妇和胎儿死亡率和发病率的危险因素。近年来,有新的证据表明,产前抑郁症和PE可能是后代几种神经发育障碍的环境风险因素。产前抑郁和PE也是相互影响的危险因素。目前,产前抑郁症和PE如何相互影响的机制及其在母婴不良结局发展中的作用尚不确定。在这篇综述中,我们概述了关于产前抑郁症和PE对后代神经发育结果影响的最新临床研究,以及这两种母体疾病如何相互影响的可能机制及其在后代神经发育中的作用,包括炎症、氧化应激和母体免疫激活。我们推测,母体抑郁症中促炎细胞因子的过度产生和皮质醇水平的升高可以改变胎儿的神经发育,母体抑郁症引起的自主神经系统功能障碍可能会加速母亲的心率并升高血压。同样,在PE中,母亲、胎盘和胎儿的炎症升高和氧化应激加剧可能会对母亲的抑郁产生负面影响,并损害后代的神经发育。需要进一步的研究来检验产前抑郁和PE对母亲和后代健康结果的综合影响,探索母亲抑郁在PE发展中的机制,并研究它们在后代神经发育中的作用。
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引用次数: 0
Lifestyle, social environment, physiological environment and cardiovascular disease 生活方式、社会环境、生理环境与心血管疾病
Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-01-01 DOI: 10.4103/hm.hm_1_22
Xuerui Tan
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引用次数: 0
Socioeconomic and clinical factors associated with disease-related knowledge of cardiac rehabilitation patients in Brazil 巴西心脏康复患者与疾病相关知识相关的社会经济和临床因素
Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-01-01 DOI: 10.4103/hm.hm_64_21
J. Loures, Gabriela S. Chaves, Renata Ribas, R. Britto, M. Marchiori, Gabriela M. Ghisi
Objective: The objective of this study was to identify socioeconomic and clinical factors associated with disease-related knowledge of cardiac rehabilitation (CR) patients. Methods: Adults with coronary artery disease (CAD) were recruited during CR Phase 1 and completed questionnaires on the 1st day of Phase 2. Disease-related knowledge was assessed by the short version of the CAD Education Questionnaire. Socioeconomic status was defined by educational level, family income, and employment status. MannWhitney U and Spearman correlation were calculated to determine the association of knowledge with socioeconomic factors, number of risk factors, and wait time between hospital discharge and start of outpatient CR. Results: A convenience sample of 39 patients were recruited. Overall, the mean knowledge was 12.00 ± 3.3, which corresponds to 60% of possible scores. Monthly family income and number of risk factors influenced medical condition knowledge (P < 0.05), and employment status influenced total knowledge (P = 0.005) and risk factor knowledge (P = 0.002). Participants with three or more risk factors presented significantly higher knowledge (P = 0.02). Those that waited more than 17 weeks to start the CR presented significantly lower knowledge (P = 0.04). Conclusion: Participants with low income and unemployed were more likely to have inadequate disease-related knowledge; however, the entire sample presented low understanding of their condition. Public health strategies and educational interventions must continue to focus on these vulnerable groups.
目的:本研究的目的是确定与心脏康复(CR)患者疾病相关知识相关的社会经济和临床因素。方法:在CR第一阶段招募冠心病患者,并于第二阶段第一天完成问卷调查。通过简易CAD教育问卷评估疾病相关知识。社会经济地位由教育水平、家庭收入和就业状况来定义。计算MannWhitney U和Spearman相关,以确定知识与社会经济因素、危险因素数量、出院和门诊CR开始之间的等待时间的关联。结果:招募了39名患者的方便样本。总体而言,平均知识为12.00±3.3,相当于可能得分的60%。家庭月收入和危险因素数量影响医疗状况知识(P < 0.05),就业状况影响总知识(P = 0.005)和危险因素知识(P = 0.002)。有三个或三个以上危险因素的参与者表现出更高的知识水平(P = 0.02)。那些等待超过17周才开始CR的人表现出明显较低的知识(P = 0.04)。结论:低收入、无业的被试对疾病相关知识的了解程度较低;然而,整个样本对他们的病情的了解程度很低。公共卫生战略和教育干预措施必须继续以这些弱势群体为重点。
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引用次数: 0
Heart diseases, anxiety disorders, and negative thoughts 心脏病、焦虑症和消极想法
Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-01-01 DOI: 10.4103/hm.hm_45_21
M. Karki, G. Mahara
The mind and the heart are inextricably linked. Depression, worry, loneliness, anger, and chronic stress are all negative mental states that can increase the risk of heart disease or worsen existing cardiac problems. Cardiomyopathy develops in response to suddenly hearing stressful news, such as a loved one diagnosed with cancer. Thus, intense emotions, such as anger, can also lead to abnormal heart rhythms. When you are stressed, your blood pressure and heart rate both rise. Chronic stress causes your body to produce harmful quantities of stress hormones such as cortisol, which can alter blood clots. All of these factors can lead to a heart attack or a stroke. Negative thoughts, feelings, or emotions may influence lifestyle patterns, increasing the risk of heart disease. People who are chronically stressed, nervous, sad, or angry are more likely to consume excessive amounts of alcohol, smoke, overeat, and exercise insufficiently– all harmful habits that are detrimental to their heart health.
心灵是密不可分的。抑郁、担忧、孤独、愤怒和慢性压力都是负面的心理状态,会增加患心脏病的风险或加剧现有的心脏问题。突然听到有压力的消息,比如爱人被诊断出患有癌症,会导致心肌病。因此,愤怒等强烈的情绪也会导致心律失常。当你有压力时,你的血压和心率都会升高。慢性压力会导致你的身体产生大量有害的压力激素,如皮质醇,这会改变血栓。所有这些因素都可能导致心脏病发作或中风。消极的想法、感受或情绪可能会影响生活方式,增加患心脏病的风险。长期压力大、紧张、悲伤或愤怒的人更有可能过量饮酒、吸烟、暴饮暴食和运动不足——所有这些都是有害于心脏健康的有害习惯。
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引用次数: 3
Decision-making experiences and decisional regret in patients receiving implanted cardioverter-defibrillators 植入心律转复除颤器患者的决策经验和决策后悔
Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2022-01-01 DOI: 10.4103/hm.hm_51_21
Idean Pourshams, Bryant Lin, Paul Wang, R. Stafford
Background: Patient education before the placement of an implantable cardioverter-defibrillator (ICD) is strongly recommended to prevent or mitigate feelings of regret and frustration in ICD recipients. Medicare guidelines for ICDs require a shared decision-making approach that focuses on patients' health goals, values, and preferences before implantation. However, many patients are not fully informed of what to expect when recovering from ICD placement or living with an ICD long-term. Objectives: Our objective is to understand decision-making processes and decisional regret in patients requiring ICDs using in-depth interviews. Methods: Nineteen patients at Stanford University Medical Center were recruited to participate in individual interviews using closed-ended and open-ended questions to engage dialogue. Notes taken during interviews were assessed and used to identify major themes. Results: Participants described a lack of adequate education about ICD postoperative recovery and long-term, postimplantation considerations such as avoiding electromagnetic fields, false-positive ICD shocks, and the esthetic effect of ICD implantation. In addition, feelings of fear and anxiety were prevalent in participants' recollections of accepting an ICD. Conclusion: Further improvement in patient education before ICD placement is needed. The decision-making process can be simplified and patient regret and frustration minimized by providing reliable information that is accessible and interactive.
背景:强烈建议在植入心律转复除颤器(ICD)之前对患者进行教育,以防止或减轻ICD接受者的后悔和沮丧情绪。针对ICD的医疗保险指南需要一种共同的决策方法,在植入前关注患者的健康目标、价值观和偏好。然而,许多患者在植入ICD后康复或长期使用ICD时,并没有完全了解预期情况。目的:我们的目的是通过深入访谈了解需要ICD的患者的决策过程和决策后悔。方法:斯坦福大学医学中心的19名患者被招募参加个人访谈,使用封闭式和开放式问题进行对话。对访谈中的笔记进行了评估,并用于确定主要主题。结果:参与者描述了缺乏关于ICD术后恢复和植入后长期考虑的充分教育,如避免电磁场、假阳性ICD电击和ICD植入的美学效果。此外,在参与者接受ICD的回忆中,恐惧和焦虑情绪普遍存在。结论:植入式心脏复律除颤器植入前的患者教育需要进一步改进。通过提供可访问和交互式的可靠信息,可以简化决策过程,最大限度地减少患者的后悔和沮丧。
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引用次数: 1
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Heart and Mind
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