Digital Diagnostics最新文献

{"title":"Multidisciplinary approach and diagnostic difficulties in esophageal adenocarcinoma: a case report","authors":"D. A. Akhmedzyanova, O. K. Yutsevich, R. V. Reshetnikov, O. V. Tashchyаn, Sergey S. Pirogov, M. P. Mazurova, N. N. Volchenko, A. K. Kamalov, Y. Shumskaya, M. Mnatsakanyan","doi":"10.17816/dd561354","DOIUrl":"https://doi.org/10.17816/dd561354","url":null,"abstract":"Esophageal adenocarcinoma is one of the most common gastrointestinal cancers. Esophagogastroduodenoscopy (EGD) with biopsy and immunohistochemistry are used to detect neoplasm at an early stage. Definitive diagnosis requires not only highly specialized equipment, but also depends on the skills of endoscopist and pathologist. We report a case of a 35-year-old man with progressive dysphagia caused by gastroesophageal cancer. Numerous EGD studies, computed tomography and barium X-ray swallow revealed an extensive esophageal lesion, but pathomorphologic examinations did not confirm malignancy within a year. The results of histological studies showed pyloric gland adenoma, adenoma from parietal or oncocytic cells with high-grade dysplasia. EGD with targeted biopsy at the specialized center confirmed the tumor malignancy. This clinical case demonstrates the importance of clinical symptoms and additional instrumental methods for making a definitive diagnosis if the biopsy results are ambiguous.","PeriodicalId":34831,"journal":{"name":"Digital Diagnostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139253227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual platform for computer simulation of radionuclide imaging in nuclear cardiology. Comparison with clinical data.","authors":"N. Denisova, M. Gurko, Inna Kolinko, Alexey Ansheles, Vladimir Sergienko","doi":"10.17816/dd595696","DOIUrl":"https://doi.org/10.17816/dd595696","url":null,"abstract":"Background: In the field of radionuclide imaging, in vivo human clinical studies are limited due to radiation exposure and ethical concerns, so mathematical modeling and in silico computer simulations based on digital models are becoming increasingly important. In the English-language literature, this approach is called \"Virtual clinical trials\". Aims: The aim of this work is to develop software tools for simulation of radionuclide visualization of myocardial perfusion by SPECT/CT with 99mTc-MIBI and to perform studies aimed at improving the accuracy of SPECT. Materials and methods: A software package \"Virtual platform for simulations of the SPECT/CT method in nuclear cardiology\" was developed using digital patient models, a scanner and assessment of the state of the myocardium using digital images of the left ventricle (LV) in the form of a \"polar map\". Verification of the software package was performed by comparing with clinical data obtained at the National Medical Research Center of Cardiology (Moscow). Simulation computer tests were carried out, in which the accuracy of assessing the state of the myocardium was studied, depending on the approach to normalizing the \"polar map\" and corrective factors in the reconstruction algorithm. Results: The results of simulation tests showed that the assessment of LV myocardial perfusion significantly depends on the method of normalizing the \"polar map\" and taking into account corrective factors in the reconstruction algorithm. The most accurate estimates were obtained when calculating the normalization coefficient from the average value of activity in the normal zone of the myocardium. It is shown that the common approach to pixel normalization with maximum intensity can lead to errors. The results of \"virtual\" trials were fully consistent with clinical observations. Conclusions: The transition from relative normalized values of activity in the myocardium to absolute quantitative estimates will allow removing the existing limitations and uncertainties and is the main condition for improving the diagnostic accuracy of the SPECT/CT method in nuclear cardiology.","PeriodicalId":34831,"journal":{"name":"Digital Diagnostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139268547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI for differential diagnosis of primary extra-axial brain tumors (a review of radiomic studies)","authors":"E. Surovcev, Aleksandr Kapishnikov","doi":"10.17816/dd569149","DOIUrl":"https://doi.org/10.17816/dd569149","url":null,"abstract":"Обоснование. Анализ данных магнитно-резонансной томографии (МРТ) является основным методом для предоперационной дифференциальной диагностики первичных внемозговых опухолей (ПВО). Однако точное разграничение различных ПВО только на основе визуальной оценки данных МРТ может быть затруднена. Радиомика это количественный подход к анализу данных медицинских изображений, позволяющий выявить взаимосвязь данных визуализации с фенотипическими и генотипическими особенностями опухолей. Ранее в ряде аналитических публикаций проводилось обобщение результатов исследований, посвященных дифференциальной диагностике ПВО на основе принципов радиомики. Быстрое накопление новых клинических примеров и увеличение количества исследований по данной проблеме обуславливают необходимость их дальнейшего анализа и систематизации, что и послужило основанием для выполнения настоящей работы. Цель систематизировать существующие данные о возможностях радиомики для дифференциальной диагностики первичных внемозговых опухолей. Материалы и методы. Проведены поиск и анализ публикаций на русском и английском языках за последние пять лет. Поиск осуществлялся в системах PubMed/Medline, Google Scholar и еLibrary. В окончательный анализ включено 19 публикаций касающиеся дифференциальной диагностики первичных внемозговых опухолей в которых были приведены радиомические признаки, использованные для дифференциальной диагностики новообразований. Результаты. Выполнен поиск публикаций, касающихся дифференциальной диагностики ПВО на основе принципов радиомики. После анализа публикаций в обзор было включено 19 исследований. Во всех исследованиях было показано наличие взаимосвязи между радиомическими параметрами (текстурными и гистограммными) и типом опухоли. Эффективность дифференциальной диагностики опухолей радиомическими моделями превосходила эффективность классификации новообразований рентгенологами. Наиболее часто использовались следующие алгоритмы для создания магических моделей классификации опухолей на основе радиомических параметров: метод опорных векторов, логистическая регрессия, случайный лес. Методы опорных векторов и логистической регрессии продемонстрировали лучшие и более стабильные результаты. Заключение. Использование концепции радиомики показывает многообещающие результаты в дифференциальной диагностике первичных внемозговых опухолей. Дальнейшее развитие этого направления требует стандартизации как методов сегментации, так и набора признаков, а также эффективного метода математического моделирования.","PeriodicalId":34831,"journal":{"name":"Digital Diagnostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139269178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The difficulty of making a differential diagnosis in a young female patient with ascites: a case report","authors":"T. S. Nefedova, Y. Shumskaya, Marta V. Yurazh, A. S. Panferov, Pavel V. Senchikhin, Alexey E. Grabarnik, I. O. Shchekoturov, M. Mnatsakanyan","doi":"10.17816/dd568134","DOIUrl":"https://doi.org/10.17816/dd568134","url":null,"abstract":"There is a difficulty in differential diagnosis between peritoneal tuberculosis and malignant ovarian neoplasm due to the similarity of clinical picture, laboratory and instrumental examination data. In this article, we describe a clinical case of a young patient with ascites and gastrointestinal symptoms. The examination revealed ovarian masses and signs of peritoneal carcinomatosis, as well as lung nodules. However, the clinical presentation was atypical for ovarian cancer, and lung lesions were suspicious for tuberculous, which allowed to hypothesize regarging tuberculosis of multiple localizations. The diagnosis was confirmed by laparoscopy with biopsy of the involved tissues and subsequent histologic and laboratory confirmation of the etiologic role of Mycobacterium tuberculosis. The described case demonstrates the importance of using all available diagnostic methods in establishing the causes of ascites in young female patients for differential diagnosis between specific and neoplastic etiologies.","PeriodicalId":34831,"journal":{"name":"Digital Diagnostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139268692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left ventricular non-compaction with ventricular aneurysm in 6-year-old patient","authors":"Bauyrzhan Bakhytovich Kaliyev, Tairkhan Bekpolatovich Dautov, Bibissara Yerekesh","doi":"10.17816/dd551837","DOIUrl":"https://doi.org/10.17816/dd551837","url":null,"abstract":"Ventricular noncompaction is a very rare form of cardiomyopathy and its combination with a ventricular aneurysm is even more uncommon. We present a clinical case of a 6-year-old girl, who was admitted to our clinic with complaints of physical exertion. Echocardiography demonstrated prominent trabeculations in the left ventricular wall with a lateral basal part ballooning out, findings consistent with noncompaction of the left ventricular myocardium with an aneurysm. Magnetic resonance imaging confirmed evidence of non-compacted myocardium with a non-compacted /compacted myocardium ratio of 2.7. Impaired left ventricular systolic function and left ventricular aneurysm with myocardial scarring were found on magnetic resonance imaging. Coronary angiography excluded coronary artery disease, which justified myocardial scarring due to microcirculatory disorder of non-compacted myocardium","PeriodicalId":34831,"journal":{"name":"Digital Diagnostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135992606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation for radioiodine therapy in patients with differentiated thyroid cancer, modern perspective. Review of the literature.","authors":"Maria V. Ryzhenko, Konstantin Y. Slashchuk, Alexey A. Trukhin, Karina I. Avramova, Marina S. Sheremeta","doi":"10.17816/dd532728","DOIUrl":"https://doi.org/10.17816/dd532728","url":null,"abstract":"Thyroid cancer is the most common tumor of the endocrine system, 1-3% of all malignant neoplasms as of 2021. Differentiated forms, papillary and follicular, with a relatively favorable prognosis, are detected in 90% of cases. In recent years, therapy for well-differentiated thyroid cancer (WDTC) has not significantly changed and includes surgical treatment, hormone therapy, radioiodine therapy when indicated, and dynamic monitoring with possible expansion to advanced therapeutic options in cases of disease recurrence. However, there are a range of unresolved issues that are continuing to be actively investigated by new laboratory and instrumental methods. Particularly, one of these issues is the preparation in patients with differentiated thyroid cancer for radioiodine therapy.
 Radioiodine therapy (RIT) is considered as one of the first targeted therapies for thyroid cancer with a history of over 80 years of use, the main purpose of which is ablation of residual thyroid tissue as well as therapy of distant and/or regional metastases of thyroid cancer. The combination of surgical treatment and subsequent radioiodine therapy provides a favorable prognosis in patients with WDTC, but there is a remaining possibility of insufficient response to radioiodine therapy, which may be associated with multiple factors, including the phase of preparation for RIT.
 The publication provides a review of the scientific literature on the aspects of preparation of patients with WDTC for radioiodine therapy. The principles of preparation are based on the recommendations of the leading expert societies and studies published in the world practice, as well as known side effects during preparation for radioiodine therapy and thereafter, their impact on patients' quality of life, effectiveness and long-term results of treatment.
 Materials and Methods
 Scientific articles and reviews from Medline, Cochrane, and Google Scholar databases were searched by keywords, and recommendations regarding WDTC of the scientific societies were used. Articles in Russian and English with full-text availability were selected; those published after January 2023 were excluded. A systematic evaluation of 130 sources was performed, general trends in the modern approach to patient preparation for radioiodine therapy and current problems were highlighted, and results and conclusions were formulated","PeriodicalId":34831,"journal":{"name":"Digital Diagnostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136352743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"99mTc-MIBI washout rate as a marker of myocardial mitochondrial dysfunction; a systematic review and meta-analysis","authors":"Konstantin Valeryevich Zavadovsky, Marina Olegovna Gulya","doi":"10.17816/dd568668","DOIUrl":"https://doi.org/10.17816/dd568668","url":null,"abstract":"The systemic review and metaanalysis describes the features of the 99mTc-MIBI pharmacokinetics, which make it possible to assess mitochondrial myocardial dysfunction in vivo, and also shows the main clinical application points the phenomenon of accelerated 99mTc-MIBI washout rate. The study of foreign and domestic literature described the informativeness of the reverse redistribution phenomenon and the 99mTc-MIBI washout rate as a marker of mitochondrial myocardial dysfunction was carried out. The analysis included publications selected by the following keywords and their combinations: mitochondrial dysfunction, 99mTc-MIBI, 99mTc-Tetrofosmin, myocardial perfusion scintigraphy, reverse redistribution, washout rate. A total of 17 publications have been collected for a systematic review of clinical studies in the field of studying and evaluating mitochondrial dysfunction according to myocardial perfusion scintigraphy. 6 studies with a case-control design were selected to perform the metaanalysis.
 An analysis of the literature shows that the severity of the reverse redistribution phenomenon and 99mTc-MIBI washout rate are associated with the microstructure of mitochondria and myocardium, contractility and hemodynamics of the left ventricle, the level of natriuretic peptides, exercise tolerance, severity of coronary atherosclerosis, oxidative metabolism of the myocardium, the risk of cardiovascular events. According to the data of the meta-analysis, it was found that the rate of washout rate was statistically significantly accelerated in patients with heart pathology, as compared to the control. Thus, the assessment of mitochondrial function by 99mTc-MIBI washout assessment can provide additional information about the functional state of the myocardium.","PeriodicalId":34831,"journal":{"name":"Digital Diagnostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136294344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic resonance imaging in the diagnosis of a rare disease - incontinentia pigmenti (Bloch-Sulzberger syndrome) on the example of a clinical case","authors":"Igor Yarmola, Anatoly V. Anikin, Dmitry A. Gankin, Lyubov E. Fomina, Milana A. Basargina, Natalia A. Kharitonova, Aleksandr A. Pushkov, Zhanin Ilya, Olga B. Kondakova","doi":"10.17816/dd430154","DOIUrl":"https://doi.org/10.17816/dd430154","url":null,"abstract":"Incontinentia pigmenti, also known as BlochSulzberger syndrome, is a rare hereditary disease characterized by typical skin rashes and involvement of other organs and systems. Magnetic resonance imaging stands as the primary method for visualizing the structural pathology of the brain and predicting neurological manifestations in an affected child.
 Diagnosing incontinentia pigmenti predominantly falls within the domain of dermatologists; verification is performed by molecular genetic analysis of the IKBKG gene. This study involved magnetic resonance imaging of the brain in a patient with skin rashes, characteristic of BlochSulzberger syndrome, and deletion in the IKBKG gene, where numerous foci of ischemia, hemorrhages, and lesions of the tracts were detected.
 Magnetic resonance imaging of the brain in patients with BlochSulzberger syndrome is used to evaluate the severity of damage to the brain substance, which makes it possible to explain the cause of neurological symptoms and correct habilitation, as well as predict the development of the child.","PeriodicalId":34831,"journal":{"name":"Digital Diagnostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134904378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum in “Volumetry versus linear diameter lung nodule measurement: an ultra-low-dose computed tomography lung cancer screening study” (doi: 10.17816/DD117481)","authors":"M. M. Suchilova, I. A. Blokhin, O. Aleshina, Victor A. Gombolevskiy, R. V. Reshetnikov, Viktor Yu. Bosin, O. Omelyanskaya","doi":"10.17816/dd569112","DOIUrl":"https://doi.org/10.17816/dd569112","url":null,"abstract":"In the article \"Volumetry versus linear diameter lung nodule measurement: an ultra-low-dose computed tomography lung cancer screening study\" published in Digital Diagnostics journal Volume 4 Issue 1 in 2023 (doi: 10.17816/DD117481) contained an error in the paragraph with data of funding sources for the study. At the request of the authors team, the error was eliminated, the original version of the published article and the information on the journals site was replaced with the corrected one. Correct text of the changed: This paper was prepared by a group of authors as part of the research work (USIS No. 123031400009-1) in accordance with the Order issued by the Moscow Health Care Department No. 1196 dated December 21, 2022. The authors and the publisher apologize to readers for the published error and express their confidence that this mistake could not significantly affect the perception and interpretation of the results of the study described in the text of the article.","PeriodicalId":34831,"journal":{"name":"Digital Diagnostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139335847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural gray matter changes in primary progressive aphasia variants","authors":"Diliara R. Akhmadullina, Rodion N. Konovalov, Yulia A. Shpilyukova, Ekaterina Yu. Fedotova","doi":"10.17816/dd567783","DOIUrl":"https://doi.org/10.17816/dd567783","url":null,"abstract":"Background: Primary progressive aphasia (PPA) is a rare neurodegenerative disease with high clinical, genetic and pathomorphological heterogeneity that greatly complicates its diagnosis. Voxel-based morphometry (VBM) can be used to objectively assess structural gray matter changes and determine atrophy patterns of PPA variants, which can improve the diagnosis of the disease and our understandings of its pathogenesis.
 Aims: The aim of our work was to evaluate the patterns of atrophy in each of the PPA variants in comparison with the control group.
 Materials and methods: Patients with a diagnosis of one of the PPA variants, established in accordance with the current diagnostic criteria, were included in the main group. The control group consisted of healthy volunteers without any neurological symptoms and structural brain changes according to MRI. All participants underwent brain MRI, obtained images were processed and used for VBM. VBM was performed with a comparison of gray matter volume between each of the PPA variants and the control group. The study was adjusted for gender, age, and intracranial volume of the participants.
 Results: 25 patients with nonfluent (nfvPPA), 11 - semantic (svPPA), and 9 - logopenic (lvPPA) PPA variants and 20 healthy volunteers were included in the study. The VBM showed that there is a specific atrophy pattern in each of the PPA variants with predominant involvement of the frontal and insular lobes in nfvPPA, the temporal lobe and hippocampus in svPPA, and a more diffuse frontotemporal pattern in lvPPA.
 Conclusions: The study revealed gray matter atrophy patterns specific to each of the PPA variants. Obtained results mainly correspond to the clinical presentations of the disease. At the same time, some findings (e.g. absence of the posterior perisylvian atrophy in lvPPA as well as reduced gray matter volume of the orbitofrontal cortex and cerebellum in nfvPPA, premotor cortex, precentral and inferior frontal gyrus in svPPA, and motor cortex in lvPPA) do not correlate with the usual understanding of PPA pathogenesis and require further study.","PeriodicalId":34831,"journal":{"name":"Digital Diagnostics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134913200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}