Pub Date : 2023-09-09DOI: 10.1183/13993003.congress-2023.pa3525
bahar kubat, Mehmet Cüneyt Tetikkurt, Haluk Burçak Sayman
Aim: The aim of this study is to compare the traditional clinical and laboratory parameters used for the diagnosis and activity of sarcoidosis with 68Ga citrate PET/CT and 18F-FDG PET/CT findings. Material and Method: 19 68Ga citrate PET/CT scans and 20 68Ga citrate PET/CT and 18F-FDG PET/CT scans of both patients were included in the study. Demographic features of the cases, clinical findings, chest X-ray, Thorax CT, respiratory function tests, laboratory results, bronchoscopic and extrapulmonary organ biopsies, 68Ga citrate PET/CT and 18F-FDG PET/CT scan results retrospectively. The obtained data were uploaded to computer systems. Analysis was performed using statistical methods. Conclusion: A statistically significant difference was found between 68Ga Citrate PET/CT result and acceptance of active sarcoidosis (p=0.001), acceptance of clinical sarcoidosis (p=0.029), and probability of sarcoidosis (p=0.020). There was no statistically significant difference between the 18F-FDG PET/CT and 68Ga Citrate PET/CT results of patients who were accepted as clinical sarcoidosis (p=0.1000). Extrathoracic involvement was detected in %44,4 of 18 patients with active sarcoidosis in 68Ga citrate PET/CT. The cost advantage of 68Ga Citrate PET/CT has been demonstrated. Results: The success of 68Ga citrate PET/CT has been proven in the diagnosis of sarcoidosis, activation and detection of extrathoracic involvement and determination of biopsy sites. No significant difference was found in the comparison with 18F-FDG PET/CT
{"title":"Comparison of Conventional Clinical and Laboratory Findings with 18F-FDG PET/CT and 68Ga Citrate PET/CT in terms of Diagnostic Utility and Disease Activity Among Sarcoidosis Patients","authors":"bahar kubat, Mehmet Cüneyt Tetikkurt, Haluk Burçak Sayman","doi":"10.1183/13993003.congress-2023.pa3525","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa3525","url":null,"abstract":"<b>Aim:</b> The aim of this study is to compare the traditional clinical and laboratory parameters used for the diagnosis and activity of sarcoidosis with <sup>68</sup>Ga citrate PET/CT and <sup>18</sup>F-FDG PET/CT findings. Material and Method: 19 <sup>68</sup>Ga citrate PET/CT scans and 20 <sup>68</sup>Ga citrate PET/CT and <sup>18</sup>F-FDG PET/CT scans of both patients were included in the study. Demographic features of the cases, clinical findings, chest X-ray, Thorax CT, respiratory function tests, laboratory results, bronchoscopic and extrapulmonary organ biopsies, <sup>68</sup>Ga citrate PET/CT and <sup>18</sup>F-FDG PET/CT scan results retrospectively. The obtained data were uploaded to computer systems. Analysis was performed using statistical methods. Conclusion: A statistically significant difference was found between <sup>68</sup>Ga Citrate PET/CT result and acceptance of active sarcoidosis (p=0.001), acceptance of clinical sarcoidosis (p=0.029), and probability of sarcoidosis (p=0.020). There was no statistically significant difference between the <sup>18</sup>F-FDG PET/CT and <sup>68</sup>Ga Citrate PET/CT results of patients who were accepted as clinical sarcoidosis (p=0.1000). Extrathoracic involvement was detected in %44,4 of 18 patients with active sarcoidosis in <sup>68</sup>Ga citrate PET/CT. The cost advantage of <sup>68</sup>Ga Citrate PET/CT has been demonstrated. Results: The success of <sup>68</sup>Ga citrate PET/CT has been proven in the diagnosis of sarcoidosis, activation and detection of extrathoracic involvement and determination of biopsy sites. No significant difference was found in the comparison with <sup>18</sup>F-FDG PET/CT","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"2016 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136260680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-09DOI: 10.1183/13993003.congress-2023.pa3533
Stevan Ivković, Dušan Ivković, Aleksandar Ivković
{"title":"Incidentaloma in covid 19","authors":"Stevan Ivković, Dušan Ivković, Aleksandar Ivković","doi":"10.1183/13993003.congress-2023.pa3533","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa3533","url":null,"abstract":"","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136265105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-09DOI: 10.1183/13993003.congress-2023.pa2293
Mathieu Bottier, Andreia Lucia Do Nascimento Pinto, Emily Howieson, Britt J Van Akker, Oliver Hamilton, Ioannis Katramados, Jane Davies, Amelia Shoemark, Claire Hogg, Thomas Burgoyne
Mucociliary clearance is an essential defence mechanism against chronic airway infection and inflammation. Defects in ciliary motility are either primary, as in primary ciliary dyskinesia (PCD), or secondary. Identification of mucociliary clearance defects allows the implementation of appropriate management. High-speed video-microscopy (HSVM) is used to assess cilia motility from nasal biopsy samples. It is a time consuming and subjective requiring significant expertise. Computer vision can improve the identification of cilia motility defects by minimising subjectivity and reducing the cost and time to analyse samples. Using an artificial intelligence platform (Intel® Geti™), we have trained several models using archived HSVM videos from patients referred to the Royal Brompton Hospital who were diagnosed with PCD and display a range of ciliary motility phenotypes and non-PCD controls. The videos used are converted to optical flow to provide temporal information to the machine learning algorithm. We are training the platform to classify different categories of beat pattern: Immotile, Normal, Reduced Amplitude and Rotation. Models also include assessing sample quality and cilia beating orientation. The preliminary data based on projects currently in development are promising: the model classifying normal beating vs immotile cilia (around 30,000 frames) has a predictive accuracy of 100% and the beat pattern recognition model (around 25,000 frames) has a predictive accuracy of 97%. Further training and testing are ongoing, and more models are being developed to include a greater range of motility phenotypes and to encompass chronic inflammatory lung diseases.
{"title":"Utilising computer vision artificial intelligence to identify defects in airway ciliary motility and mucociliary clearance","authors":"Mathieu Bottier, Andreia Lucia Do Nascimento Pinto, Emily Howieson, Britt J Van Akker, Oliver Hamilton, Ioannis Katramados, Jane Davies, Amelia Shoemark, Claire Hogg, Thomas Burgoyne","doi":"10.1183/13993003.congress-2023.pa2293","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa2293","url":null,"abstract":"Mucociliary clearance is an essential defence mechanism against chronic airway infection and inflammation. Defects in ciliary motility are either primary, as in primary ciliary dyskinesia (PCD), or secondary. Identification of mucociliary clearance defects allows the implementation of appropriate management. High-speed video-microscopy (HSVM) is used to assess cilia motility from nasal biopsy samples. It is a time consuming and subjective requiring significant expertise. Computer vision can improve the identification of cilia motility defects by minimising subjectivity and reducing the cost and time to analyse samples. Using an artificial intelligence platform (Intel® Geti™), we have trained several models using archived HSVM videos from patients referred to the Royal Brompton Hospital who were diagnosed with PCD and display a range of ciliary motility phenotypes and non-PCD controls. The videos used are converted to optical flow to provide temporal information to the machine learning algorithm. We are training the platform to classify different categories of beat pattern: Immotile, Normal, Reduced Amplitude and Rotation. Models also include assessing sample quality and cilia beating orientation. The preliminary data based on projects currently in development are promising: the model classifying normal beating vs immotile cilia (around 30,000 frames) has a predictive accuracy of 100% and the beat pattern recognition model (around 25,000 frames) has a predictive accuracy of 97%. Further training and testing are ongoing, and more models are being developed to include a greater range of motility phenotypes and to encompass chronic inflammatory lung diseases.","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136201067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-09DOI: 10.1183/13993003.congress-2023.pa3528
Riccardo Ripamonti, Bianca Corrò, Silvia Pagani, Stefania Raschi, Pierfranco Usai, Cristiano Bonacina, Roberta Cattaneo, Monica Bernareggi, Chiara Melacini, Serena Bencini, Martina Piluso, Francesca D'Arcangelo, Luca Parachini, Chiara Milano, Roberta Ciceri, Angela Brancaforte, Marcello Intotero, Paolo Scarpazza
Introduction: COVID-19 pneumonia often causes long term radiological and functional lung alterations. Aims and objectives: Primary endpoint of our retrospective study was to evaluate the frequency and the extension after 1 year from the discharge of CT alterations (conventional and quantitative study) in the lungs of patients (pts) admitted to Vimercate Hospital for COVID-19 associated ARDS (CARDS). Secondarily, alterations in pulmonary function tests (PFTs) and 6 minute walking distance (6MWD) were investigated. Methods: 66 pts with CARDS entered the study and no one had previous chronic lung disease. Volumetric data were measured with Synapse 3D software and were compared with 20 healthy subjects of the same age. Categorical data were expressed as frequencies and percentages. Continuous variables were represented using median values. Multivariate logistic regression was performed for every category of data. Statistical significance was considered for p-value <0.05. Results: At 1-year follow-up only 5/66 pts (7.6%) showed a normal CT pattern. Conventional CT patterns were mostly ground-glass opacities, reticulations, subpleurical curves, traction bronchiectasis and fibrotic-like alterations. Quantitative analysis pointed out that the median lung volume of pts was significantly lower than that of the control group (p=0.011). The median compromised lung volume (VCo), including emphysema, interstitial impairment and consolidation was significantly higher in CARDS than in the control group (p≤0.001). DLCO, TLC and 6MWD were found to be negatively correlated with VCo. Conclusions: Our study highlights the need of a longer radiological and functional follow-up post-CARDS.
{"title":"Quantitative CT lung alterations and lung function in COVID-19 associated ARDS: 1-year follow-up","authors":"Riccardo Ripamonti, Bianca Corrò, Silvia Pagani, Stefania Raschi, Pierfranco Usai, Cristiano Bonacina, Roberta Cattaneo, Monica Bernareggi, Chiara Melacini, Serena Bencini, Martina Piluso, Francesca D'Arcangelo, Luca Parachini, Chiara Milano, Roberta Ciceri, Angela Brancaforte, Marcello Intotero, Paolo Scarpazza","doi":"10.1183/13993003.congress-2023.pa3528","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa3528","url":null,"abstract":"<i><b>Introduction</b></i>: COVID-19 pneumonia often causes long term radiological and functional lung alterations. <i><b>Aims and objectives</b></i>: Primary endpoint of our retrospective study was to evaluate the frequency and the extension after 1 year from the discharge of CT alterations (conventional and quantitative study) in the lungs of patients (pts) admitted to Vimercate Hospital for COVID-19 associated ARDS (CARDS). Secondarily, alterations in pulmonary function tests (PFTs) and 6 minute walking distance (6MWD) were investigated. <i><b>Methods</b></i>: 66 pts with CARDS entered the study and no one had previous chronic lung disease. Volumetric data were measured with Synapse 3D software and were compared with 20 healthy subjects of the same age. Categorical data were expressed as frequencies and percentages. Continuous variables were represented using median values. Multivariate logistic regression was performed for every category of data. Statistical significance was considered for p-value <0.05. <i><b>Results</b></i>: At 1-year follow-up only 5/66 pts (7.6%) showed a normal CT pattern. Conventional CT patterns were mostly ground-glass opacities, reticulations, subpleurical curves, traction bronchiectasis and fibrotic-like alterations. Quantitative analysis pointed out that the median lung volume of pts was significantly lower than that of the control group (p=0.011). The median compromised lung volume (VCo), including emphysema, interstitial impairment and consolidation was significantly higher in CARDS than in the control group (p≤0.001). DLCO, TLC and 6MWD were found to be negatively correlated with VCo. <i><b>Conclusions</b></i>: Our study highlights the need of a longer radiological and functional follow-up post-CARDS.","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"231 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136259453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-09DOI: 10.1183/13993003.congress-2023.pa3539
Bart P.C. Hoppe, Gijs C.M. Ven, Tijmen, J.W.T. Van De Wel, Rajen, S.R.S. Ramai, Pieter E. Postmus
Introduction: Primary spontaneous pneumothorax (PSP) patients are probably exposed to a high burden of radiation. These patients are usually young and radiation exposure can be harmful. Aim and objectives The aim of this study is to analyse the amount of radiation exposure in primary spontaneous pneumothorax patients during the first event and subsequent episodes. Methods: Patients with primary spontaneous pneumothorax were retrospectively analyzed for the number of chest x rays and chest CT scans related to the diagnosis/treatment of the pneumothorax in an academic (Leiden University Medical Center) and a teaching hospital (Alrijne) in the Netherlands. The number of imaging studies was counted for the first episode and all subsequent episodes of ipsilateral and contralateral recurrence. Results: From January 2015 till December 2022 the medical files of 180 primary spontaneous pneumothorax patients were analyzed. An average number of 20 chest x rays were performed per patient. In the academic center half of these patients received one or more chest CT scans. In the teaching hospital a chest CT was performed in one third of all pneumothorax patients. Conclusions: These findings suggest that the radiation exposure is high in spontaneous pneumothorax patients. Aims to reduce recurrence (smoking cessation and detecting and treating high risk cases with thoracic surgery for the first episode such as Birt-Hogg-Dubé patients), as well as other techniques to confirm a diagnosis of pneumothorax or evaluate the efficacy of chest tube drainage (ultrasound) are needed 1,2. References 1. Critical Care 2013; 17(5): R208 2. Chest 2011; 140: 859-66
简介:原发性自发性气胸(PSP)患者可能暴露在高负荷的辐射中。这些患者通常很年轻，辐射暴露可能是有害的。目的和目的本研究的目的是分析原发性自发性气胸患者在首次发作和随后发作期间的辐射暴露量。方法:回顾性分析荷兰一家学术医院(Leiden University Medical Center)和一家教学医院(Alrijne)原发性自发性气胸患者与气胸诊断/治疗相关的胸部x线片和胸部CT扫描次数。计算首次发作和随后所有同侧和对侧复发的影像学检查次数。结果:对2015年1月至2022年12月180例原发性自发性气胸患者的医疗档案进行分析。每位患者平均做了20次胸部x光检查。在学术中心，这些患者中有一半接受了一次或多次胸部CT扫描。在教学医院，三分之一的气胸患者进行了胸部CT检查。结论:提示自发性气胸患者的辐射暴露程度较高。需要以减少复发为目的(戒烟、首次发病即行胸外科手术的高危病例如birt - hogg - dub患者)，以及其他确认气胸诊断或评价胸管引流(超声)疗效的技术1,2。引用1。重症监护2013;17(5): r208胸部2011;140: 859 - 66
{"title":"Radiation exposure in primary spontaneous pneumothorax patients.","authors":"Bart P.C. Hoppe, Gijs C.M. Ven, Tijmen, J.W.T. Van De Wel, Rajen, S.R.S. Ramai, Pieter E. Postmus","doi":"10.1183/13993003.congress-2023.pa3539","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa3539","url":null,"abstract":"<b>Introduction:</b> Primary spontaneous pneumothorax (PSP) patients are probably exposed to a high burden of radiation. These patients are usually young and radiation exposure can be harmful. Aim and objectives The aim of this study is to analyse the amount of radiation exposure in primary spontaneous pneumothorax patients during the first event and subsequent episodes. <b>Methods:</b> Patients with primary spontaneous pneumothorax were retrospectively analyzed for the number of chest x rays and chest CT scans related to the diagnosis/treatment of the pneumothorax in an academic (Leiden University Medical Center) and a teaching hospital (Alrijne) in the Netherlands. The number of imaging studies was counted for the first episode and all subsequent episodes of ipsilateral and contralateral recurrence. <b>Results:</b> From January 2015 till December 2022 the medical files of 180 primary spontaneous pneumothorax patients were analyzed. An average number of 20 chest x rays were performed per patient. In the academic center half of these patients received one or more chest CT scans. In the teaching hospital a chest CT was performed in one third of all pneumothorax patients. <b>Conclusions:</b> These findings suggest that the radiation exposure is high in spontaneous pneumothorax patients. Aims to reduce recurrence (smoking cessation and detecting and treating high risk cases with thoracic surgery for the first episode such as Birt-Hogg-Dubé patients), as well as other techniques to confirm a diagnosis of pneumothorax or evaluate the efficacy of chest tube drainage (ultrasound) are needed 1,2. References 1. Critical Care 2013; 17(5): R208 2. Chest 2011; 140: 859-66","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136259538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-09DOI: 10.1183/13993003.congress-2023.pa3996
Carmen Streibel, C. Corin Willers, Grzegorz Bauman, Orso Pusterla, Oliver Bieri, Enno Stranzinger, Ben Brabandt, Marion Curdy, Yasmin Salem, Carmen Casaulta, Insa Korten, Sophie Yammine, Philipp Latzin, Elisabeth Kieninger
Background: Structural and functional magnetic resonance imaging (MRI) of the lung is well suited for repeated measurements especially in children, as patients are not exposed to ionizing radiation. Matrix-Pencil decomposition (MP)-MRI is a highly promising approach allowing simultaneous assessment of lung ventilation and perfusion without the need of contrast agent, hyperpolarized gas and/or specific breathing maneuvers. Aim: To report our experience of seven years lung MP-MRI measurements in children. Methods: Since 2016 we performed more than 900 functional MP-MRI lung scans in children aged 5-18 years on a standard clinical 1.5 Tesla Siemens MRI scanner. Scans were used for both, study investigations and clinical questions, and were performed together with structural lung MRI measurements. Results: MP-MRI is easily feasible even in young children and of short duration (8 minutes on average). Outcome parameters like ventilation and perfusion defect percentage (VDP, QDP) and defect distribution index (DDI) are suited as study endpoints in lung diseases, e.g. cystic fibrosis, primary ciliary dyskinesia and congenital diaphragmatic hernia. In addition, MP-MRI is of help in clinical decision making, such as assessing the residual, local ventilation and perfusion after surgery for congenital airway malformation or necrotising pneumonia. Conclusions: We have pioneered the implementation of MP-MRI into clinics and shown that MP-MRI is applicable in various study settings. It helps guiding clinical decisions and is a promising tool for follow-up of chronic lung diseases providing spatially resolved information on functional deficits.
{"title":"Seven years of functional lung MRI in children: experiences of more than 900 matrix-pencil decomposition (MP-)MRI measurements in clinics and research","authors":"Carmen Streibel, C. Corin Willers, Grzegorz Bauman, Orso Pusterla, Oliver Bieri, Enno Stranzinger, Ben Brabandt, Marion Curdy, Yasmin Salem, Carmen Casaulta, Insa Korten, Sophie Yammine, Philipp Latzin, Elisabeth Kieninger","doi":"10.1183/13993003.congress-2023.pa3996","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa3996","url":null,"abstract":"<b>Background:</b> Structural and functional magnetic resonance imaging (MRI) of the lung is well suited for repeated measurements especially in children, as patients are not exposed to ionizing radiation. Matrix-Pencil decomposition (MP)-MRI is a highly promising approach allowing simultaneous assessment of lung ventilation and perfusion without the need of contrast agent, hyperpolarized gas and/or specific breathing maneuvers. <b>Aim:</b> To report our experience of seven years lung MP-MRI measurements in children. <b>Methods:</b> Since 2016 we performed more than 900 functional MP-MRI lung scans in children aged 5-18 years on a standard clinical 1.5 Tesla Siemens MRI scanner. Scans were used for both, study investigations and clinical questions, and were performed together with structural lung MRI measurements. <b>Results:</b> MP-MRI is easily feasible even in young children and of short duration (8 minutes on average). Outcome parameters like ventilation and perfusion defect percentage (VDP, QDP) and defect distribution index (DDI) are suited as study endpoints in lung diseases, e.g. cystic fibrosis, primary ciliary dyskinesia and congenital diaphragmatic hernia. In addition, MP-MRI is of help in clinical decision making, such as assessing the residual, local ventilation and perfusion after surgery for congenital airway malformation or necrotising pneumonia. <b>Conclusions:</b> We have pioneered the implementation of MP-MRI into clinics and shown that MP-MRI is applicable in various study settings. It helps guiding clinical decisions and is a promising tool for follow-up of chronic lung diseases providing spatially resolved information on functional deficits.","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136259963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-09DOI: 10.1183/13993003.congress-2023.pa3532
Elmira Chuvakova, Lina Zaripova, Timur Sarsengaliyev, Manana Peradze, Abay Baigenzhin
Introduction: The identification of pulmonary thromboembolism (PTE) associated with COVID-19 requires careful diagnostic approach. Objective: to analyse the multislice CT (MSCT) data from patients with COVID-19. Methods: MSCT of 2,746 patients with COVID-19 was analysed, apart from them 112 patients with increased D-dimer underwent CT pulmonary angiography with post-processing analysis. In 14 patients the diagnosis was verified morphologically(autopsies). Results: CT pulmonary angiography revealed PTE in 45.9% of COVID-19 patients with elevated D-dimer. Indirect signs of PTE included: -areas of increased density, often triangular in shape (arrow, Fig.1A) and linear thickening (arrow, Fig.1B); -Westermarck9s symptom - local depletion of the lung pattern (arrow, Fig.1C) in three mutually perpendicular projections; -expansion of small branches of pulmonary arteries as signs of pulmonary hypertension (Fig.1D). Central and parietal emboli were visible in the lumen of the subsubsegmental and subsegmental arteries of the lungs (Fig.1E, F). The central embolus was surrounded by the contrast - a symptom of "polo stamp" (Fig.1G). Thrombus in the pulmonary artery was morphologically confirmed (Fig.1H, hematoxylin and eosin staining). Conclusions: CT pulmonary angiography allows revealing the acute thromboembolism of small branches of pulmonary artery and should be recommended in case of COVID-19 with elevated D-dimer level.
{"title":"Multislice CT in the visualisation of thromboembolism of small branches of pulmonary arteries in COVID-19","authors":"Elmira Chuvakova, Lina Zaripova, Timur Sarsengaliyev, Manana Peradze, Abay Baigenzhin","doi":"10.1183/13993003.congress-2023.pa3532","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa3532","url":null,"abstract":"<b>Introduction:</b> The identification of pulmonary thromboembolism (PTE) associated with COVID-19 requires careful diagnostic approach. <b>Objective:</b> to analyse the multislice CT (MSCT) data from patients with COVID-19. <b>Methods:</b> MSCT of 2,746 patients with COVID-19 was analysed, apart from them 112 patients with increased D-dimer underwent CT pulmonary angiography with post-processing analysis. In 14 patients the diagnosis was verified morphologically(autopsies). <b>Results:</b> CT pulmonary angiography revealed PTE in 45.9% of COVID-19 patients with elevated D-dimer. Indirect signs of PTE included: -areas of increased density, often triangular in shape (arrow, Fig.1A) and linear thickening (arrow, Fig.1B); -Westermarck9s symptom - local depletion of the lung pattern (arrow, Fig.1C) in three mutually perpendicular projections; -expansion of small branches of pulmonary arteries as signs of pulmonary hypertension (Fig.1D). Central and parietal emboli were visible in the lumen of the subsubsegmental and subsegmental arteries of the lungs (Fig.1E, F). The central embolus was surrounded by the contrast - a symptom of \"polo stamp\" (Fig.1G). Thrombus in the pulmonary artery was morphologically confirmed (Fig.1H, hematoxylin and eosin staining). <b>Conclusions:</b> CT pulmonary angiography allows revealing the acute thromboembolism of small branches of pulmonary artery and should be recommended in case of COVID-19 with elevated D-dimer level.","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136260113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-09DOI: 10.1183/13993003.congress-2023.pa3994
Carmen Streibel, C Corin Willers, Grzegorz Bauman, Orso Pusterla, Oliver Bieri, Marion Curdy, Matthias Horn, Carmen Casaulta, Steffen Berger, Gabriela Marta Dekany, Elisabeth Kieninger, Andreas Bartenstein, Philipp Latzin
Objectives: In patients with congenital diaphragmatic hernia (CDH) the exact functional outcome of the affected lung side is still unknown, mainly due to the lack of spatially resolved diagnostic tools. Functional matrix-pencil decomposition (MP-) lung MRI fills this gap as it measures side-specific ventilation and perfusion. We aimed to assess the overall and side-specific pulmonary long-term outcome of patients with CDH using lung function tests and functional MP-MRI. Methods: Thirteen school aged children with CDH (seven with small and six with large defect-sized CDH, defined as >50% of the chest wall circumference being devoid of diaphragm tissue) and thirteen healthy matched controls underwent spirometry, multiple-breath washout and MP-MRI. Main outcomes were forced expiratory volume in 1 second (FEV1), lung clearance index (LCI), ventilation defect percentage (VDP), perfusion defect percentage (QDP). Results: Patients with a large CDH showed significantly reduced overall lung function compared to healthy controls [mean difference; 95%-CIadjusted.: FEV1 (z-score) -4.26 (-5.61 to -2.92), LCI2.5 (TO) 1.12 (0.47 to 1.76), VDP (%) 8.59 (3.58 to 13.60), QDP (%) 17.22 (13.16 to 21.27)] and to patients with a small CDH. Side-specific examination by MP-MRI revealed particularly reduced ipsilateral ventilation and perfusion in patients with a large CDH [mean difference to contralateral side; 95%-CIadjusted.: VDP (%) 14.80 (10.50 to 19.00), QDP (%) 23.50 (1.75 to 45.20)]. Conclusions: Patients with a large CDH showed impaired overall lung function with particular limitation of the ipsilateral side. MP-MRI is a promising tool to provide valuable side-specific functional information in the follow-up of patients with CDH.
{"title":"Side-specific assessment of lung function in children with congenital diaphragmatic hernia - functional matrix pencil decomposition MRI as a promising diagnostic tool","authors":"Carmen Streibel, C Corin Willers, Grzegorz Bauman, Orso Pusterla, Oliver Bieri, Marion Curdy, Matthias Horn, Carmen Casaulta, Steffen Berger, Gabriela Marta Dekany, Elisabeth Kieninger, Andreas Bartenstein, Philipp Latzin","doi":"10.1183/13993003.congress-2023.pa3994","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa3994","url":null,"abstract":"<b>Objectives:</b> In patients with congenital diaphragmatic hernia (CDH) the exact functional outcome of the affected lung side is still unknown, mainly due to the lack of spatially resolved diagnostic tools. Functional matrix-pencil decomposition (MP-) lung MRI fills this gap as it measures side-specific ventilation and perfusion. We aimed to assess the overall and side-specific pulmonary long-term outcome of patients with CDH using lung function tests and functional MP-MRI. <b>Methods:</b> Thirteen school aged children with CDH (seven with small and six with large defect-sized CDH, defined as >50% of the chest wall circumference being devoid of diaphragm tissue) and thirteen healthy matched controls underwent spirometry, multiple-breath washout and MP-MRI. Main outcomes were forced expiratory volume in 1 second (FEV1), lung clearance index (LCI), ventilation defect percentage (VDP), perfusion defect percentage (QDP). <b>Results:</b> Patients with a large CDH showed significantly reduced overall lung function compared to healthy controls [mean difference; 95%-CIadjusted.: FEV1 (z-score) -4.26 (-5.61 to -2.92), LCI2.5 (TO) 1.12 (0.47 to 1.76), VDP (%) 8.59 (3.58 to 13.60), QDP (%) 17.22 (13.16 to 21.27)] and to patients with a small CDH. Side-specific examination by MP-MRI revealed particularly reduced ipsilateral ventilation and perfusion in patients with a large CDH [mean difference to contralateral side; 95%-CIadjusted.: VDP (%) 14.80 (10.50 to 19.00), QDP (%) 23.50 (1.75 to 45.20)]. <b>Conclusions:</b> Patients with a large CDH showed impaired overall lung function with particular limitation of the ipsilateral side. MP-MRI is a promising tool to provide valuable side-specific functional information in the follow-up of patients with CDH.","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"369 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136260643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-09DOI: 10.1183/13993003.congress-2023.pa4011
Jude Wellens-Mensah, Matthew Embley, Paul Cadden, Mudher Al-Khairalla, Peter Williamson, Mark Spears
Introduction: Early use of anti-fibrotic medication in pulmonary fibrosis protects lung function, prolonging quality of life. Increased use of CT could enable detection of disease before significant symptoms develop. The majority of CT scans are requested by primary care teams, general physicians or surgeons. However these groups are unfamiliar with the significance of classical descriptors for pulmonary fibrosis used by radiologists. A recent case (patient presented with disabling breathlessness requiring oxygen at diagnosis, a year after CT for cholecystitis) led us to audit our ILD clinic with the aim of determining local prevalence. Methods: 116 patient records at a University Clinic were reviewed, to ascertain the prevalence of CT abdomen scans prior to referral. In addition to reports with ’refer to respiratory’ we sought words commonly employed to describe fibrosing interstitial lung diseases (reticulation, honeycombing, ground glass). Findings 11 patients had abdominal CT scans before referral. 5 had fibrosis present. Time from these scans to clinic review ranged from 3 to 36 months. Only 2 reports recommended referral to the respiratory team. A further 2 contained descriptors but no guidance, and one report failed to describe the fibrosis. Reports recommending ’refer to respiratory’ were followed. Of the remaining three patients, all were referred by their GP following presentation with symptoms. Conclusions: Abdominal CTs could enable early referral to ILD clinics, but this opportunity is lost due to reporting habits. Clear guidance to requestors is followed and should be employed as standard. Radiology training and education should target this issue, to improve outcomes for patients.
{"title":"A missed opportunity - fibrosis on previous abdominal CTs in patients referred to an ILD clinic","authors":"Jude Wellens-Mensah, Matthew Embley, Paul Cadden, Mudher Al-Khairalla, Peter Williamson, Mark Spears","doi":"10.1183/13993003.congress-2023.pa4011","DOIUrl":"https://doi.org/10.1183/13993003.congress-2023.pa4011","url":null,"abstract":"<b>Introduction:</b> Early use of anti-fibrotic medication in pulmonary fibrosis protects lung function, prolonging quality of life. Increased use of CT could enable detection of disease before significant symptoms develop. The majority of CT scans are requested by primary care teams, general physicians or surgeons. However these groups are unfamiliar with the significance of classical descriptors for pulmonary fibrosis used by radiologists. A recent case (patient presented with disabling breathlessness requiring oxygen at diagnosis, a year after CT for cholecystitis) led us to audit our ILD clinic with the aim of determining local prevalence. <b>Methods:</b> 116 patient records at a University Clinic were reviewed, to ascertain the prevalence of CT abdomen scans prior to referral. In addition to reports with ’refer to respiratory’ we sought words commonly employed to describe fibrosing interstitial lung diseases (reticulation, honeycombing, ground glass). Findings 11 patients had abdominal CT scans before referral. 5 had fibrosis present. Time from these scans to clinic review ranged from 3 to 36 months. Only 2 reports recommended referral to the respiratory team. A further 2 contained descriptors but no guidance, and one report failed to describe the fibrosis. Reports recommending ’refer to respiratory’ were followed. Of the remaining three patients, all were referred by their GP following presentation with symptoms. <b>Conclusions:</b> Abdominal CTs could enable early referral to ILD clinics, but this opportunity is lost due to reporting habits. Clear guidance to requestors is followed and should be employed as standard. Radiology training and education should target this issue, to improve outcomes for patients.","PeriodicalId":34850,"journal":{"name":"Imaging","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136260884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Human cysticercosis, caused by the parasitic infection of Taenia Solium, is an important challenge for public health in Ecuador and other countries where poor sanitary conditions are a key factor for its appearance. In this series of cases, we publish the imaging findings corresponding to three patients treated in 2022 at the Center of Medical Specialties “Comité del Pueblo” Quito - Ecuador, in which, through radiographic images, multiple radiodense lesions were found in different anatomical regions which follow the typical pattern of distribution parallel to the muscular tissues of the affected region, generating the radiological sign known as “rice grain calcifications”, which corresponds to the presence of Disseminated Cysticercosis (DCC)in the muscular tissue of the host.
{"title":"Disseminated cysticercosis in humans","authors":"S. S. Celi Simbaña, D. S. Andrade Mora","doi":"10.1556/1647.2023.00150","DOIUrl":"https://doi.org/10.1556/1647.2023.00150","url":null,"abstract":"Human cysticercosis, caused by the parasitic infection of Taenia Solium, is an important challenge for public health in Ecuador and other countries where poor sanitary conditions are a key factor for its appearance. In this series of cases, we publish the imaging findings corresponding to three patients treated in 2022 at the Center of Medical Specialties “Comité del Pueblo” Quito - Ecuador, in which, through radiographic images, multiple radiodense lesions were found in different anatomical regions which follow the typical pattern of distribution parallel to the muscular tissues of the affected region, generating the radiological sign known as “rice grain calcifications”, which corresponds to the presence of Disseminated Cysticercosis (DCC)in the muscular tissue of the host.","PeriodicalId":34850,"journal":{"name":"Imaging","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45762288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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