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A prospective, randomized, open-label, active-controlled study to compare the efficacy and safety of levocetirizine and bepotastine in chronic spontaneous urticaria 一项前瞻性、随机、开放标签、主动对照研究,比较左西替利嗪和贝泊司汀治疗慢性自发性荨麻疹的疗效和安全性
Pub Date : 2023-04-01 DOI: 10.4103/cdr.cdr_105_21
G. Menghani, N. Kaur, K. Vyas, Kalpana Gupta, K. Maheshwari, R. Singh
Background: Management of chronic spontaneous urticaria (CSU) is challenging because of its unpredictable course and negative influence on the quality of life. Second-generation antihistaminics are the first-line treatment. Levocetirizine, a time-tested antihistaminic, has proven efficacy in CSU. Bepotastine, which was previously used for allergic rhinitis and conjunctivitis, has recently been tried in urticaria. It may be a better alternative to levocetirizine because of its long-term safety. Objectives: The aim of this study was to compare the efficacy and safety of levocetirizine and bepotastine in CSU. Materials and Methods: A randomized, active-controlled, open-label, prospective, interventional study was conducted on 70 patients of CSU. After initial clinical assessment and baseline investigations, bepotastine and levocetirizine were prescribed to separate groups of 35 patients for a period of 12 weeks. Urticaria Activity Score (UAS) and Dermatology Life Quality Index (DLQI) were used for assessing the severity of disease. Follow-up visits were planned for evaluating clinical improvement and adverse effects. Results were compared using Mann–Whitney U test and Fisher's exact test. P < 0.05 was considered statistically significant. Results: The reduction in UAS and DLQI score in levocetirizine group was better than bepotastine group, and the results were statistically significant at 12 weeks (P = 0.0001). Incidence of adverse effects such as sedation and weight gain was higher in levocetirizine group at 12th week (P = 0.0003). Conclusion: The result of the study reveals the superiority of levocetirizine in terms of efficacy, i.e., reduction of UAS and DLQI scores. Bepotastine although slightly lower in efficacy shows better safety profile.
背景:慢性自发性荨麻疹(CSU)由于其不可预测的病程和对生活质量的负面影响,其治疗具有挑战性。第二代抗组胺药是一线治疗。左西替利嗪是一种经过时间测试的抗组胺药,已被证明在CSU中有效。以前用于治疗过敏性鼻炎和结膜炎的贝他斯汀,最近已被用于治疗荨麻疹。由于其长期安全性,它可能是左西替利嗪的更好替代品。目的:本研究的目的是比较左西替利嗪和贝他斯汀治疗CSU的疗效和安全性。材料与方法:对70例CSU患者进行随机、主动对照、开放标签、前瞻性、介入性研究。在初步临床评估和基线调查后,对35名患者分别开贝他斯汀和左西替利嗪,为期12周。荨麻疹活动评分(UAS)和皮肤病生活质量指数(DLQI)用于评估疾病的严重程度。计划随访以评估临床改善和不良反应。使用Mann-Whitney U检验和Fisher精确检验对结果进行比较。P<0.05被认为具有统计学意义。结果:左西替利嗪组的UAS和DLQI评分的降低优于贝他斯汀组,且在12周时结果具有统计学意义(P=0.0001)。左西替利嗪组在12周后镇静和体重增加等不良反应的发生率更高(P=0.0003),即UAS和DLQI得分的降低。贝他斯汀虽然疗效稍低,但显示出更好的安全性。
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引用次数: 0
A retrospective study to analyze the pattern of referrals to the department of dermatology, venereology, and leprosy at a tertiary care center in Karnataka 回顾性研究分析在卡纳塔克邦的三级保健中心皮肤科,性病和麻风病的转诊模式
Pub Date : 2023-04-01 DOI: 10.4103/cdr.cdr_12_22
S. Somaiah, S. Manjunath, T. Nagesh
Background: Dermatology is mainly considered as an outpatient specialty. In an institutional set up, the patients who are hospitalized in nondermatology departments may have skin diseases. The patients visiting other outpatient departments might have skin disorders. Such patients are referred to the department of dermatology and can be diagnosed and treated better in dermatology departments. Objectives: The objective was to analyze the pattern of referrals to the department of dermatology, venereology, and leprosy from other departments of the hospital. Materials and Methods: The records of the department of dermatology, venereology, and leprosy were analyzed for referrals between September 2019 and February 2020. Results: There were 214 males (46.8%) and 188 (53.2%) females in the study. The mean age of the patients in the study was 40.9 ± 20.8 years. Maximum number of referrals were received from the department of general medicine (192 cases, 47.7%), followed by general surgery (64 cases, 15.9%). Infections and infestations accounted for 183 (45.5%) cases out of the 402 referrals, and eczematous disorders were seen in 58 (14.4%) cases. The referring departments mentioned their dermatological diagnosis in 24% of the cases and were found to be correct in 18% of cases. Conclusion: The common dermatological conditions are often undiagnosed or misdiagnosed by nondermatologist, leading to incorrect treatment, and contributes to delay in treatment. By focusing on improving the training of undergraduate and postgraduate students in the conditions for which dermatology referrals are usually sought might help in improving their knowledge and later help them treat patients better.
背景:皮肤科主要被认为是门诊专科。在医疗机构中,在非皮肤科住院的患者可能患有皮肤病。到其他门诊就诊的病人可能有皮肤病。这类患者转诊到皮肤科,在皮肤科可以得到更好的诊断和治疗。目的:目的是分析从医院其他科室转到皮肤科、性病科和麻风病科的情况。材料与方法:分析2019年9月至2020年2月期间皮肤科、性病科和麻风病科的转诊记录。结果:男性214例(46.8%),女性188例(53.2%)。患者的平均年龄为40.9±20.8岁。转诊最多的是普通内科(192例,47.7%),其次是普通外科(64例,15.9%)。在402例转诊病例中,感染和侵染占183例(45.5%),湿疹性疾病占58例(14.4%)。在24%的病例中,转诊部门提到了他们的皮肤科诊断,18%的病例被发现是正确的。结论:常见皮肤病常被非皮肤科医师漏诊或误诊,导致治疗错误,延误治疗。在通常寻求皮肤科转诊的情况下,通过重点改进对本科生和研究生的培训,可能有助于提高他们的知识,并在以后帮助他们更好地治疗病人。
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引用次数: 0
Punctate palmoplantar keratoderma: A case report and literature review 点状掌跖角化病1例报告及文献复习
Pub Date : 2023-04-01 DOI: 10.4103/cdr.cdr_49_21
J. Prathibha, Vijay V Aithal
Punctured palmoplantar keratodermas are rare autosomal-dominant keratodermas presenting as asymptomatic, tiny hyperkeratotic pigmented papules on the palms and soles. We present a rare case of punctate palmoplantar keratoderma type 1 extending to the dorsum of the foot with pes cavus deformity of the foot. We did the literature review.
穿刺掌跖角化病是一种罕见的常染色体显性角化病,表现为手掌和足底无症状、微小的角化过度色素丘疹。我们报告了一例罕见的1型点状掌跖角化病,延伸至足背并伴有足腔畸形。我们做了文献综述。
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引用次数: 0
Nevus unius lateris with coexisting unilateral atrophoderma vermiculatum: A rare presentation 猩红痣合并单侧蠕状萎缩皮病:罕见的表现
Pub Date : 2023-04-01 DOI: 10.4103/cdr.cdr_32_22
S. Singh, Deeksha Goyal, A. Mohan
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引用次数: 0
Vitiligo: Prevalence, clinical patterns, and efficacy of narrow band ultraviolet B phototherapy 白癜风:流行,临床模式,和窄带紫外线B光疗的疗效
Pub Date : 2023-04-01 DOI: 10.4103/cdr.cdr_49_22
Yoganand J. Phulari, Ram Kukreja, R. Hiremath, Chetan C. Patil, P. Patel
Background: Vitiligo denotes an acquired primary, usually progressive, melanocytopenia of unknown etiology, and clinically manifested by circumscribed achromic macules often associated with leukotrichia. Objective: The objective was to assess the prevalence and various clinical patterns of vitiligo and to study the efficacy of narrow-band ultraviolet B (NB-UVB) radiation. Materials and Methods: A prospective case series study was carried out at dermatology outpatient department (OPD), of tertiary care center in Central India on 50 patients of Vitiligo, who were diagnosed clinically, age ranging from 5 to 70 years of age. A thorough history and clinical examination as per institutional protocol was done for all the patients included in the study. Patients were exposed to NB-UVB rays in a phototherapy unit (Dermaindia Spiegel Series) with a standard protocol. Two scores designed for the assessment of vitiligo are Vitiligo Area Severity Index and Wallace Rule of Nines. Results: During the period of two years, 6638 patients were seen in dermatology OPD, out of which 129 patients were having vitiligo clinically. Thus, the prevalence of vitiligo was 1.9% in our study. The mean age in male was 40.4 years and that of female was 30.85 years. The female-to-male ratio was 2:3. 6% had a positive family history of vitiligo. The most common site affected was leg (pretibial region) (48%). Two patients (4%) were in Category– 0, 12 patients (24%) were in Category– I, 24 patients (48%) were in Category-II, and 12 patients (24%) were in Category– III, when graded according to their improvement. Forty-five patients (90%) had vitiligo vulgaris, two patients (4%) had segmental vitiligo, and one patient (2%) each of acrofacial vitiligo, lip-tip vitiligo, and focal vitiligo. On comparing the level of significance before treatment and after 2 months of treatment, after 4 and 6 months of treatment, and before treatment and at the end of treatment, it was found that the results were statistically highly significant. Thus, indicating that the improvement in the disease after NB-UVB therapy is statically significant. Conclusion: Our study found 1.9% prevalence of vitiligo among patients attending OPD. On comparing the level of significance, before treatment and at the end of treatment, it was found that the results were statistically highly significant with respect to improvement. Side effects were minimal in our participants. Thus, our study concludes that NB-UVB radiation is an effective and safe therapy for vitiligo.
背景:白癜风是一种病因不明的获得性原发性,通常为进行性,黑色素细胞减少症,临床表现为界限分明的色斑,常伴有白斑病。目的:了解白癜风的患病率及各种临床表现,探讨窄带紫外线B (NB-UVB)辐射治疗白癜风的疗效。材料与方法:在印度中部三级保健中心皮肤科门诊(OPD)对50例临床诊断为白癜风的患者进行前瞻性病例系列研究,年龄从5岁到70岁不等。所有纳入研究的患者都按照机构方案进行了全面的病史和临床检查。患者在标准方案的光疗单元(Dermaindia Spiegel系列)中暴露于NB-UVB射线。白癜风的两个评分是白癜风区域严重程度指数和华莱士九分法则。结果:2年期间皮肤科门诊共就诊6638例,其中临床表现为白癜风的患者129例。因此,在我们的研究中,白癜风的患病率为1.9%。男性平均年龄40.4岁,女性平均年龄30.85岁。男女比例为2:3。6%的人有白癜风家族史。最常见的受累部位是腿部(胫骨前区域)(48%)。2例患者(4%)为- 0类,12例患者(24%)为- 1类,24例患者(48%)为- 2类,12例患者(24%)为- 3类。普通白癜风45例(90%),节段性白癜风2例(4%),面部面部白癜风、唇尖白癜风和局灶性白癜风各1例(2%)。比较治疗前与治疗后2个月、治疗后4个月与6个月、治疗前与治疗结束时的显著性水平,发现结果具有高度统计学意义。因此,表明NB-UVB治疗后疾病的改善具有统计学意义。结论:我们的研究发现,在门诊就诊的患者中,白癜风患病率为1.9%。在比较治疗前和治疗结束时的显著性水平时,发现结果在改善方面具有统计学上的高度显著性。我们的参与者的副作用很小。因此,我们的研究得出结论,NB-UVB辐射是一种有效和安全的治疗白癜风的方法。
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引用次数: 0
Prevalence of metabolic syndrome among children with psoriasis in urban Bengaluru 班加罗尔市区牛皮癣儿童代谢综合征患病率
Pub Date : 2023-04-01 DOI: 10.4103/cdr.cdr_73_21
H. Lakshmi, L. Budamakuntla, C. M. S. Sundar
Background: Psoriasis is a common, chronic inflammatory dermatosis that often has its onset during childhood. There is increasing evidence that psoriasis in adults is associated with obesity, metabolic syndrome (MetS), and associated comorbidities. Such an association raises concern with regard to the long-term health implications for children with psoriasis and suggests that better awareness, evaluation, and management of overweight and obese patients and associated metabolic disease are warranted in this population. Objectives: The present study was undertaken to evaluate the prevalence of MetS in childhood psoriasis. Materials and Methods: It was a cross-sectional, observational study in children aged between 6 and 18 years with psoriasis involving >10% body surface area. All children were evaluated and investigated for MetS. Results: The study included 32 children, female-to-male ratio was 5:3 with an earlier presentation in females. Body mass index was >75th centile in eight children, and among them, four had >90th centile. The waist circumference of four children was in the 90th percentile for age. Mean fasting plasma glucose, serum triglycerides, and serum high-density lipoprotein (HDL) were 89.81 ± 6.56 mg/dl, 109.25 ± 36.29 mg/dl, and 37.78 ± 7.40 mg/dl, respectively. Four of 32 children met the criteria for MetS, 14 others had at least one criterion. Fifty percent (16/32) of them had HDL lower than 40 mg/dl. The mean duration of psoriasis was more in those with MetS (4.75 years vs. 1.44 years, P = 0.005). Conclusion: Pediatric psoriasis is found to be associated with obesity and MetS. The presence of obesity with psoriasis mandates evaluation for MetS.
背景:牛皮癣是一种常见的慢性炎症性皮肤病,通常在儿童期发病。越来越多的证据表明,成人牛皮癣与肥胖、代谢综合征(MetS)和相关合并症有关。这种关联引起了人们对牛皮癣儿童长期健康影响的关注,并表明有必要在这一人群中更好地认识、评估和管理超重和肥胖患者及相关代谢疾病。目的:本研究旨在评估儿童牛皮癣中MetS的患病率。材料与方法:这是一项横断面观察性研究,研究对象为6 - 18岁的牛皮癣患儿,患者体表面积为bb10 - 10%。对所有儿童进行met评估和调查。结果:本研究纳入32例儿童,男女比例为5:3,女性发病较早。8名儿童体重指数为>75百分位,其中4名儿童体重指数为>90百分位。4名儿童的腰围在年龄的第90百分位。平均空腹血糖、血清甘油三酯和血清高密度脂蛋白(HDL)分别为89.81±6.56 mg/dl、109.25±36.29 mg/dl和37.78±7.40 mg/dl。32名儿童中有4名符合met的标准,另外14名至少有一项标准。50%(16/32)的人HDL低于40 mg/dl。met患者牛皮癣的平均持续时间更长(4.75年比1.44年,P = 0.005)。结论:小儿牛皮癣与肥胖和MetS相关。伴有牛皮癣的肥胖需要对MetS进行评估。
{"title":"Prevalence of metabolic syndrome among children with psoriasis in urban Bengaluru","authors":"H. Lakshmi, L. Budamakuntla, C. M. S. Sundar","doi":"10.4103/cdr.cdr_73_21","DOIUrl":"https://doi.org/10.4103/cdr.cdr_73_21","url":null,"abstract":"Background: Psoriasis is a common, chronic inflammatory dermatosis that often has its onset during childhood. There is increasing evidence that psoriasis in adults is associated with obesity, metabolic syndrome (MetS), and associated comorbidities. Such an association raises concern with regard to the long-term health implications for children with psoriasis and suggests that better awareness, evaluation, and management of overweight and obese patients and associated metabolic disease are warranted in this population. Objectives: The present study was undertaken to evaluate the prevalence of MetS in childhood psoriasis. Materials and Methods: It was a cross-sectional, observational study in children aged between 6 and 18 years with psoriasis involving >10% body surface area. All children were evaluated and investigated for MetS. Results: The study included 32 children, female-to-male ratio was 5:3 with an earlier presentation in females. Body mass index was >75th centile in eight children, and among them, four had >90th centile. The waist circumference of four children was in the 90th percentile for age. Mean fasting plasma glucose, serum triglycerides, and serum high-density lipoprotein (HDL) were 89.81 ± 6.56 mg/dl, 109.25 ± 36.29 mg/dl, and 37.78 ± 7.40 mg/dl, respectively. Four of 32 children met the criteria for MetS, 14 others had at least one criterion. Fifty percent (16/32) of them had HDL lower than 40 mg/dl. The mean duration of psoriasis was more in those with MetS (4.75 years vs. 1.44 years, P = 0.005). Conclusion: Pediatric psoriasis is found to be associated with obesity and MetS. The presence of obesity with psoriasis mandates evaluation for MetS.","PeriodicalId":34880,"journal":{"name":"Clinical Dermatology Review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42725350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Profile of dermatological disorders among construction workers: A cross-sectional study 建筑工人皮肤病概况:一项横断面研究
Pub Date : 2023-04-01 DOI: 10.4103/cdr.cdr_113_21
Nafina Jasmine, S. Shetty, S. Pai
Background: The construction industry is a growing industry worldwide, including India, employing a large population. Construction workers perform a variety of work including mixing concrete and carrying heavy objects. Occupational contact dermatitis is a significant occupational dermatosis, cement being the most important agent and is an occupational hazard. Objective: The objective of this study was to estimate the prevalence of occupational skin diseases among construction workers. Materials and Methods: This cross-sectional study was conducted in Manipal, Karnataka, among 300 construction workers. A detailed inquiry was made on demographic parameters such as age, sex, nature of work, duration of the job, chemicals exposed to, symptoms, and use of protective devices. They were examined to note the symptoms, clinical pattern, and distribution of lesions. Results: The majority of the workers belonged to the age group between 20 and 29 years. The common skin disorders noticed were callosities (17.33%), traumatic injuries (10%), dermatophyte infections (8.33%), and dermatitis (5.7%) along with few other dermatoses encountered due to increased exposure to heat and due to increased wet work in workers who did not wear protective devices. Conclusions: There is a lack of preemployment and periodic medical examinations for construction workers. Common dermatoses seen among the construction workers were mainly due to the lack of preventive measures. Hence, it is important to raise health awareness to recognize early signs and symptoms of various dermatoses and educate regarding the use of personal protective equipment.
背景:建筑行业是世界范围内一个不断发展的行业,包括印度,雇用大量人口。建筑工人从事各种各样的工作,包括搅拌混凝土和搬运重物。职业性接触性皮炎是一种重要的职业性皮肤病,水泥是最主要的病原体,是一种职业性危害。目的:本研究旨在了解建筑工人职业性皮肤病的流行情况。材料与方法:本横断面研究在卡纳塔克邦的马尼帕尔进行,调查对象为300名建筑工人。对人口统计参数进行了详细调查,如年龄、性别、工作性质、工作时间、接触的化学品、症状和防护装置的使用情况。他们被检查以记录症状、临床模式和病变分布。结果:职工年龄以20 ~ 29岁为主。常见的皮肤疾病是老茧(17.33%)、外伤性损伤(10%)、皮肤真菌感染(8.33%)和皮炎(5.7%),还有一些其他皮肤病是由于暴露在高温下的时间增加和没有佩戴防护装置的工人在潮湿的工作中工作时间增加而引起的。结论:建筑工人就业前体检和定期体检不足。建筑工人常见的皮肤病主要是由于缺乏预防措施。因此,重要的是要提高健康意识,以识别各种皮肤病的早期体征和症状,并就个人防护装备的使用进行教育。
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引用次数: 0
Effective role of teledermatology in managing chronic urticaria patients during the COVID-19 pandemic 远程皮肤科在COVID-19大流行期间治疗慢性荨麻疹患者中的有效作用
Pub Date : 2023-04-01 DOI: 10.4103/cdr.cdr_101_21
Y. Pathania
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引用次数: 0
Coexistence of lupus vulgaris and scrofuloderma in an immunocompetent patient: A rare presentation 寻常狼疮和阴囊皮病共存在一个免疫功能正常的病人:一个罕见的表现
Pub Date : 2023-04-01 DOI: 10.4103/cdr.cdr_37_21
Navneet Kaur, Amandeep Saluja, K. Vyas, Kalpana Gupta
Tuberculosis (TB) may involve cutaneous tissue in approximately 0.1%–0.5% of the cases. There are various morphological presentations of cutaneous TB such as lupus vulgaris (LV), scrofuloderma, TB verrucosa cutis, and tuberculids. Usually, a single form is observed in an individual, but coexistence of the multiple forms has been rarely reported in the literature. These concurrences may be considered an interesting immunological phenomenon as two immunologically different poles are occurring simultaneously. We present a case of LV and scrofuloderma in the same patient at different sites.
约0.1%-0.5%的病例可累及皮肤组织。皮肤结核有多种形态表现,如寻常性狼疮(LV)、阴囊皮病、皮肤疣状结核和结核。通常,在个体中观察到一种形式,但多种形式的共存在文献中很少报道。这些并发可能被认为是一个有趣的免疫学现象,因为两个免疫学上不同的极点同时发生。我们提出一个病例的左室和硬皮病在同一患者在不同的部位。
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引用次数: 0
Dermatological quality of life among leprosy patients residing at a rehabilitation center in North-Eastern India: A cross-sectional study 居住在印度东北部康复中心的麻风病患者的皮肤病生活质量:一项横断面研究
Pub Date : 2023-04-01 DOI: 10.4103/cdr.cdr_112_21
Sampriti Samanta, A. Bandyopadhyay, S. Bhattacherjee, A. Mukherjee
Background: Leprosy has been affecting humans since ancient times. A chronic infectious disease, it affects skin, peripheral nervous system, and other tissues which lead to nerve damage, pain, and visible deformities. The characteristic skin lesions of leprosy can lead to significant social stigmatization and functional impairments which can affect the quality of life (QoL). Objective: The present study was conducted to assess the dermatological QoL among these leprosy patients. Materials and Methods: An observational cross-sectional study was conducted among 122 leprosy patients who were receiving treatments at a rehabilitation center in North-Eastern India in a 3-month time period. The dermatology QoL Index (DQLI) questionnaire was used to assess the QoL among these patients. Descriptive statistics and logistic regression analyses were used. Results: Among a total of 122 patients, leprosy had no effect on QoL in 4.9%, small effect in 11.5%, moderate effect in 37.7%, very large effect in 43.4%, and extremely large effect in 2.5% cases. Mean DQLI score was 10.5 ± 5.1. The most affected domain was leisure and social followed by symptoms and feelings. When adjusted for predictors, age and sex were found to have a significant association with QoL. Conclusions: Leprosy with dermatological manifestations had a very large effect on QoL. The impairment was more than other chronic skin diseases, such as chronic urticaria, vitiligo, and psoriasis. It is necessary that periodic assessment of QoL should be incorporated into the management of leprosy patients.
背景:麻风病自古以来就影响着人类。它是一种慢性传染病,影响皮肤、周围神经系统和其他组织,导致神经损伤、疼痛和明显的畸形。麻风病的特征性皮肤病变可导致严重的社会污名化和功能障碍,从而影响生活质量。目的:评价麻风病患者皮肤病学生活质量。材料和方法:对122名在印度东北部一家康复中心接受治疗的麻风病患者进行了为期3个月的观察性横断面研究。采用皮肤病生活质量指数(DQLI)问卷评估患者的生活质量。采用描述性统计和逻辑回归分析。结果:122例患者中,麻风对生活质量无影响者占4.9%,影响小者占11.5%,影响中者占37.7%,影响很大者占43.4%,影响极大者占2.5%。DQLI平均评分为10.5±5.1分。受影响最大的领域是休闲和社交,其次是症状和感觉。当调整预测因子时,发现年龄和性别与生活质量有显著关联。结论:有皮肤病表现的麻风病对患者的生活质量影响很大。这种损害比其他慢性皮肤病,如慢性荨麻疹、白癜风和牛皮癣更严重。将生活质量的定期评估纳入麻风患者的管理中是必要的。
{"title":"Dermatological quality of life among leprosy patients residing at a rehabilitation center in North-Eastern India: A cross-sectional study","authors":"Sampriti Samanta, A. Bandyopadhyay, S. Bhattacherjee, A. Mukherjee","doi":"10.4103/cdr.cdr_112_21","DOIUrl":"https://doi.org/10.4103/cdr.cdr_112_21","url":null,"abstract":"Background: Leprosy has been affecting humans since ancient times. A chronic infectious disease, it affects skin, peripheral nervous system, and other tissues which lead to nerve damage, pain, and visible deformities. The characteristic skin lesions of leprosy can lead to significant social stigmatization and functional impairments which can affect the quality of life (QoL). Objective: The present study was conducted to assess the dermatological QoL among these leprosy patients. Materials and Methods: An observational cross-sectional study was conducted among 122 leprosy patients who were receiving treatments at a rehabilitation center in North-Eastern India in a 3-month time period. The dermatology QoL Index (DQLI) questionnaire was used to assess the QoL among these patients. Descriptive statistics and logistic regression analyses were used. Results: Among a total of 122 patients, leprosy had no effect on QoL in 4.9%, small effect in 11.5%, moderate effect in 37.7%, very large effect in 43.4%, and extremely large effect in 2.5% cases. Mean DQLI score was 10.5 ± 5.1. The most affected domain was leisure and social followed by symptoms and feelings. When adjusted for predictors, age and sex were found to have a significant association with QoL. Conclusions: Leprosy with dermatological manifestations had a very large effect on QoL. The impairment was more than other chronic skin diseases, such as chronic urticaria, vitiligo, and psoriasis. It is necessary that periodic assessment of QoL should be incorporated into the management of leprosy patients.","PeriodicalId":34880,"journal":{"name":"Clinical Dermatology Review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46424757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Clinical Dermatology Review
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