Pub Date : 2025-07-03DOI: 10.1177/15563316251349543
Michael S Lee, Nicholas J Pettinelli, Jack Gagné, Justin Zhu, Mackenzie Norman, Louise Atadja, Ronak J Mahatme, Scott Fong, Jay Moran, Stephen M Gillinov, Wasif Islam, Nancy Park, Andrew E Jimenez
Introduction: There is little literature reporting on the efficacy of bone marrow aspirate concentrate (BMAC) in conjunction with hip arthroscopy.
Purpose: We sought to systematically review the literature on BMAC use following hip arthroscopy, in particular, whether its use results in improved patient-reported outcome measures (PROMs).
Methods: The Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines were followed when querying PubMed, Cochrane Central Register of Controlled Trials, and Scopus in January 2023. Articles were included if they reported on pre- and postoperative outcomes for patients undergoing hip arthroscopy with concomitant BMAC and were written in English.
Results: Five articles were included in the review. A total of 252 hips undergoing BMAC and hip arthroscopy performed between 2010 and 2020 were evaluated. The average age of patients in the studies ranged between 32.8 and 48.5 years. All studies reported improved postoperative PROM scores compared to preoperative outcome scores after BMAC and hip arthroscopy. Two studies reported survivorship of 100% and 85.7%. All 5 studies conducted a subanalysis between BMAC and hip arthroscopy and a control group. Three studies reported superior outcomes in the BMAC and hip arthroscopy group, while another study reported findings that trended toward favoring the BMAC and hip arthroscopy group but that did not reach statistical significance.
Conclusion: BMAC may improve outcomes in patients undergoing hip arthroscopy. However, due to the small sample size and lack of standardized control groups, the results of this systematic review are inconclusive.
关于骨髓浓缩液(BMAC)联合髋关节镜治疗的疗效的文献报道很少。目的:我们试图系统地回顾髋关节镜术后使用BMAC的文献,特别是使用BMAC是否能改善患者报告的结果测量(PROMs)。方法:在2023年1月查询PubMed、Cochrane Central Register of Controlled Trials和Scopus时,遵循系统评价和meta分析指南的首选报告项目。如果文章报道了髋关节镜下合并BMAC患者的术前和术后结果,并以英文撰写,则纳入。结果:共纳入5篇文章。在2010年至2020年期间,共有252个髋关节接受了BMAC和髋关节镜检查。研究中患者的平均年龄在32.8至48.5岁之间。所有研究都报告了BMAC和髋关节镜手术后术后PROM评分与术前结果评分相比的改善。两项研究报告了100%和85.7%的生存率。所有5项研究都在BMAC和髋关节镜以及对照组之间进行了亚分析。三项研究报告了BMAC和髋关节镜组的优越结果,而另一项研究报告的结果倾向于BMAC和髋关节镜组,但没有达到统计学意义。结论:BMAC可改善髋关节镜患者的预后。然而,由于样本量小且缺乏标准化的对照组,本系统综述的结果尚无定论。
{"title":"Bone Marrow Aspirate Concentrate With Hip Arthroscopy in a Heterogenous Group of Patients May Result in Improved Patient-Reported Outcomes: A Systematic Review.","authors":"Michael S Lee, Nicholas J Pettinelli, Jack Gagné, Justin Zhu, Mackenzie Norman, Louise Atadja, Ronak J Mahatme, Scott Fong, Jay Moran, Stephen M Gillinov, Wasif Islam, Nancy Park, Andrew E Jimenez","doi":"10.1177/15563316251349543","DOIUrl":"10.1177/15563316251349543","url":null,"abstract":"<p><strong>Introduction: </strong>There is little literature reporting on the efficacy of bone marrow aspirate concentrate (BMAC) in conjunction with hip arthroscopy.</p><p><strong>Purpose: </strong>We sought to systematically review the literature on BMAC use following hip arthroscopy, in particular, whether its use results in improved patient-reported outcome measures (PROMs).</p><p><strong>Methods: </strong>The Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines were followed when querying PubMed, Cochrane Central Register of Controlled Trials, and Scopus in January 2023. Articles were included if they reported on pre- and postoperative outcomes for patients undergoing hip arthroscopy with concomitant BMAC and were written in English.</p><p><strong>Results: </strong>Five articles were included in the review. A total of 252 hips undergoing BMAC and hip arthroscopy performed between 2010 and 2020 were evaluated. The average age of patients in the studies ranged between 32.8 and 48.5 years. All studies reported improved postoperative PROM scores compared to preoperative outcome scores after BMAC and hip arthroscopy. Two studies reported survivorship of 100% and 85.7%. All 5 studies conducted a subanalysis between BMAC and hip arthroscopy and a control group. Three studies reported superior outcomes in the BMAC and hip arthroscopy group, while another study reported findings that trended toward favoring the BMAC and hip arthroscopy group but that did not reach statistical significance.</p><p><strong>Conclusion: </strong>BMAC may improve outcomes in patients undergoing hip arthroscopy. However, due to the small sample size and lack of standardized control groups, the results of this systematic review are inconclusive.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251349543"},"PeriodicalIF":1.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-26DOI: 10.1177/15563316251346485
Will Jiang, Sangmin Lee, Donghao Gan, Igor Latich
Background: For orthopedic oncology patients who are poor candidates for open spine surgery, minimally invasive radiofrequency ablation and cementoplasty (RFA/C) is becoming increasingly popular for managing osteolytic vertebral metastases. Purpose: We sought to characterize long-term changes in vertebral body radiographical parameters and potential risk of adjacent fractures occurring. Methods: A single-institution, retrospective study of all patients receiving RFA/C for osteolytic thoracic or lumbar vertebral body metastases from 2017 to 2023 was conducted. Vertebral body integrity was assessed by column height changes (anterior, middle, and posterior 1/3), local vertebral angle, and indirect bone mass assessment (at 3, 6, 12, and 24 months postoperatively). The latter was assessed via Hounsfield unit (HU) changes on axial computed tomography. Adjacent vertebral fractures were defined as within 3 vertebral levels above or below index site. Treatment history including radiation therapy was tracked. Results: A total of 54 vertebral levels (26 patients; mean age 59.8 ± 19.0 years; 18 females) were included (mean follow-up 15.8 ± 13.8 months). HU (bone mass proxy) stabilized after RFA/C. Except for middle column height increasing at 3 months, no column height or local angle deformity changes were detected. Adjacent fracture occurred in 4 patients (15.4%); all 4 demonstrated systemic cancer progression. Conclusions: Our findings suggest that RFA/C may provide effective long-term stabilization of the index site that is maintained for at least 1 year postoperatively. All patients who experienced an adjacent fracture occurrence demonstrated radiographic evidence of cancer progression surrounding the treatment sites that appeared unrelated to the procedure itself.
{"title":"Longitudinal Radiographical Changes Following Minimally Invasive Ablation and Cementoplasty of Osteolytic Vertebral Metastases: A Retrospective Study.","authors":"Will Jiang, Sangmin Lee, Donghao Gan, Igor Latich","doi":"10.1177/15563316251346485","DOIUrl":"10.1177/15563316251346485","url":null,"abstract":"<p><p><i>Background:</i> For orthopedic oncology patients who are poor candidates for open spine surgery, minimally invasive radiofrequency ablation and cementoplasty (RFA/C) is becoming increasingly popular for managing osteolytic vertebral metastases. <i>Purpose:</i> We sought to characterize long-term changes in vertebral body radiographical parameters and potential risk of adjacent fractures occurring. <i>Methods:</i> A single-institution, retrospective study of all patients receiving RFA/C for osteolytic thoracic or lumbar vertebral body metastases from 2017 to 2023 was conducted. Vertebral body integrity was assessed by column height changes (anterior, middle, and posterior 1/3), local vertebral angle, and indirect bone mass assessment (at 3, 6, 12, and 24 months postoperatively). The latter was assessed via Hounsfield unit (HU) changes on axial computed tomography. Adjacent vertebral fractures were defined as within 3 vertebral levels above or below index site. Treatment history including radiation therapy was tracked. <i>Results:</i> A total of 54 vertebral levels (26 patients; mean age 59.8 ± 19.0 years; 18 females) were included (mean follow-up 15.8 ± 13.8 months). HU (bone mass proxy) stabilized after RFA/C. Except for middle column height increasing at 3 months, no column height or local angle deformity changes were detected. Adjacent fracture occurred in 4 patients (15.4%); all 4 demonstrated systemic cancer progression. <i>Conclusions:</i> Our findings suggest that RFA/C may provide effective long-term stabilization of the index site that is maintained for at least 1 year postoperatively. All patients who experienced an adjacent fracture occurrence demonstrated radiographic evidence of cancer progression surrounding the treatment sites that appeared unrelated to the procedure itself.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251346485"},"PeriodicalIF":1.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-26DOI: 10.1177/15563316251347295
Olivia C Tracey, Ruth H Jones, Akshitha Adhiyaman, Emilie Lijesen, Daniel W Green, Moira M McCarthy, Andy O Miller, Peter D Fabricant
Background: Prior studies have suggested a possible association between eczema and postoperative surgical site infections (SSI) following anterior cruciate ligament reconstruction (ACL-R), presumably due to higher rates of staphylococcal colonization in patients with eczema. Purpose:We sought to determine if patients with a history of eczema are at an increased risk for postoperative SSI following ACL-R, medial patellofemoral ligament reconstruction (MPFL-R), and/or knee arthroscopy. Methods:We conducted a retrospective matched case-control study of patients aged 5 to 25 years who underwent ACL-R, MPFL-R, and/or knee arthroscopy from February 1, 2016 to February 8, 2023 at a single tertiary care facility. Cases of postoperative infection were identified as those requiring surgical irrigation and debridement (I&D) and/or postoperative oral antibiotics or had a documented visit for postoperative infection with an infectious disease specialist within 6 months of the indexed procedure. Cases and controls were matched 1:2 based on sex, age ±1 year, body mass index ±1 kg/m2, and primary Current Procedural Terminology code. Preoperative diagnosis of eczema and postoperative diagnosis of infection were compared between cases and controls. Results:Three hundred patients were analyzed (mean age 18.2 ± 3.8 years); 4% of both cases and controls had a history of eczema. Patients with postoperative SSI did not have greater odds of having an eczema diagnosis preoperatively compared to matched controls. Overall, 32% of cases required an I&D procedure; these patients did not have greater odds of having an eczema diagnosis preoperatively compared to matched controls. Conclusion:This retrospective matched case-control study suggests that a prior or current diagnosis of eczema is not associated with SSI following ACL-R, MPFL-R, or knee arthroscopy in patients aged 5 to 25 years. Level of Evidence: Level III: Case-Control Study.
{"title":"Eczema Is Not Associated with an Increased Risk of Postoperative Infection Following Arthroscopic Knee Surgeries: A Retrospective Matched Case-Control Study.","authors":"Olivia C Tracey, Ruth H Jones, Akshitha Adhiyaman, Emilie Lijesen, Daniel W Green, Moira M McCarthy, Andy O Miller, Peter D Fabricant","doi":"10.1177/15563316251347295","DOIUrl":"10.1177/15563316251347295","url":null,"abstract":"<p><p><i>Background:</i> Prior studies have suggested a possible association between eczema and postoperative surgical site infections (SSI) following anterior cruciate ligament reconstruction (ACL-R), presumably due to higher rates of staphylococcal colonization in patients with eczema. <i>Purpose:</i>We sought to determine if patients with a history of eczema are at an increased risk for postoperative SSI following ACL-R, medial patellofemoral ligament reconstruction (MPFL-R), and/or knee arthroscopy. <i>Methods:</i>We conducted a retrospective matched case-control study of patients aged 5 to 25 years who underwent ACL-R, MPFL-R, and/or knee arthroscopy from February 1, 2016 to February 8, 2023 at a single tertiary care facility. Cases of postoperative infection were identified as those requiring surgical irrigation and debridement (I&D) and/or postoperative oral antibiotics or had a documented visit for postoperative infection with an infectious disease specialist within 6 months of the indexed procedure. Cases and controls were matched 1:2 based on sex, age ±1 year, body mass index ±1 kg/m<sup>2</sup>, and primary Current Procedural Terminology code. Preoperative diagnosis of eczema and postoperative diagnosis of infection were compared between cases and controls. <i>Results:</i>Three hundred patients were analyzed (mean age 18.2 ± 3.8 years); 4% of both cases and controls had a history of eczema. Patients with postoperative SSI did not have greater odds of having an eczema diagnosis preoperatively compared to matched controls. Overall, 32% of cases required an I&D procedure; these patients did not have greater odds of having an eczema diagnosis preoperatively compared to matched controls. <i>Conclusion:</i>This retrospective matched case-control study suggests that a prior or current diagnosis of eczema is not associated with SSI following ACL-R, MPFL-R, or knee arthroscopy in patients aged 5 to 25 years. <b>Level of Evidence:</b> Level III: Case-Control Study.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251347295"},"PeriodicalIF":1.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-19DOI: 10.1177/15563316251346443
Austin C Kaidi, Joshua Zhang, Tejas Subramanian, Chad Simon, Eric Mai, Adin Ehrlich, Prerana Katiyar, Gregory Kazarian, Patawut Bovonratwet, Evan Sheha, James Dowdell, Sheeraz A Qureshi, Sravisht Iyer
Background: Far-lateral lumbar disk herniation (FLLDH) poses a surgical challenge given the difficulty in visualizing the pathology with traditional techniques. Endoscopic microdiscectomy is a novel technique for the treatment of FLLDH with decreased soft tissue disruption. Purposes: We sought to compare the efficacy of tubular versus endoscopic microdiscectomy for FLLDH. Methods: A retrospective cohort study was performed that included patients undergoing uniportal endoscopic or tubular decompression for FLLDH over a 5-year period. The primary outcome was patient-reported outcome measures (PROMs). Secondary outcomes included operative time, intraoperative radiation, length of stay (LOS), and reoperation/complication rates. Comparisons between non-paired continuous variables were done with a 2-tailed independent sample t-test. Categorical variables were compared with a χ2 or a Fisher exact test. Significance was assumed at P < .05. Results: We identified 135 patients, 64 having undergone endoscopic and 71 tubular microdiscectomy. There were no differences in operative times (67.7 vs 68.2 minutes) or LOS (945.5 vs 911.1 minutes). Endoscopic microdiscectomy was associated with increased total fluoroscopy time (105.92 vs 34.66 seconds) and intraoperative radiation dose (33.68 vs 19.12 mGy). Postoperatively, both groups had statistically significant improvements in all PROMs at early and late follow-up. There was no difference in the magnitude of improvement or the rate of postoperative complications/reoperations between the groups. Conclusion: This retrospective review found that endoscopic microdiscectomy and tubular decompression were effective techniques for the treatment of FLLDH, showing significant improvement in postoperative PROMs and no differences in postoperative complications. However, endoscopic microdiscectomy is associated with increased intraoperative radiation exposure.
背景:远外侧腰椎间盘突出症(FLLDH)是一个外科挑战,因为传统技术很难看到病理。内窥镜显微椎间盘切除术是一种治疗FLLDH的新技术,减少了软组织的破坏。目的:我们试图比较管状椎间盘切除术与内窥镜显微椎间盘切除术治疗FLLDH的疗效。方法:一项回顾性队列研究,包括5年内接受单门静脉内窥镜或小管减压治疗FLLDH的患者。主要终点是患者报告的结果测量(PROMs)。次要结果包括手术时间、术中放射、住院时间(LOS)和再手术/并发症发生率。非配对连续变量间的比较采用双尾独立样本t检验。分类变量比较采用χ2或Fisher精确检验。结果:我们确定了135例患者,64例接受了内窥镜手术,71例接受了管状显微椎间盘切除术。手术时间(67.7 vs 68.2分钟)和LOS (945.5 vs 911.1分钟)无差异。内镜下显微椎间盘切除术增加了全透视时间(105.92 vs 34.66秒)和术中辐射剂量(33.68 vs 19.12 mGy)。术后,两组在早期和晚期随访时,所有prom均有统计学显著改善。两组之间的改善程度和术后并发症/再手术率没有差异。结论:本回顾性研究发现,内镜下显微椎间盘切除术和管状减压是治疗FLLDH的有效技术,可显著改善术后PROMs,术后并发症无差异。然而,内窥镜显微椎间盘切除术与术中辐射暴露增加有关。
{"title":"Uniportal Endoscopic Microdiscectomy Is an Effective Treatment Option for Far-Lateral Lumbar Disk Herniations.","authors":"Austin C Kaidi, Joshua Zhang, Tejas Subramanian, Chad Simon, Eric Mai, Adin Ehrlich, Prerana Katiyar, Gregory Kazarian, Patawut Bovonratwet, Evan Sheha, James Dowdell, Sheeraz A Qureshi, Sravisht Iyer","doi":"10.1177/15563316251346443","DOIUrl":"10.1177/15563316251346443","url":null,"abstract":"<p><p><i>Background:</i> Far-lateral lumbar disk herniation (FLLDH) poses a surgical challenge given the difficulty in visualizing the pathology with traditional techniques. Endoscopic microdiscectomy is a novel technique for the treatment of FLLDH with decreased soft tissue disruption. <i>Purposes</i>: We sought to compare the efficacy of tubular versus endoscopic microdiscectomy for FLLDH. <i>Methods</i>: A retrospective cohort study was performed that included patients undergoing uniportal endoscopic or tubular decompression for FLLDH over a 5-year period. The primary outcome was patient-reported outcome measures (PROMs). Secondary outcomes included operative time, intraoperative radiation, length of stay (LOS), and reoperation/complication rates. Comparisons between non-paired continuous variables were done with a 2-tailed independent sample <i>t-</i>test. Categorical variables were compared with a χ<sup>2</sup> or a Fisher exact test. Significance was assumed at <i>P</i> < .05. <i>Results</i>: We identified 135 patients, 64 having undergone endoscopic and 71 tubular microdiscectomy. There were no differences in operative times (67.7 vs 68.2 minutes) or LOS (945.5 vs 911.1 minutes). Endoscopic microdiscectomy was associated with increased total fluoroscopy time (105.92 vs 34.66 seconds) and intraoperative radiation dose (33.68 vs 19.12 mGy). Postoperatively, both groups had statistically significant improvements in all PROMs at early and late follow-up. There was no difference in the magnitude of improvement or the rate of postoperative complications/reoperations between the groups. <i>Conclusion</i>: This retrospective review found that endoscopic microdiscectomy and tubular decompression were effective techniques for the treatment of FLLDH, showing significant improvement in postoperative PROMs and no differences in postoperative complications. However, endoscopic microdiscectomy is associated with increased intraoperative radiation exposure.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251346443"},"PeriodicalIF":1.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-17DOI: 10.1177/15563316251343034
Tyler D DeSena, LaYow C Yu, S Robert Rozbruch, Taylor J Reif, Jidapa Wongcharoenwatana, Jason S Hoellwarth
Background: Management of total knee arthroplasty (TKA) periprosthetic joint infection (PJI) can prompt knee fusion or transfemoral amputation, both associated with poor mobility. The titanium transcutaneous osseointegrated nail (TiTON) provides superior mobility versus traditional socket prostheses but has been minimally studied for amputees with prior TKA PJI. Purpose: This study investigated the complications and mobility experience of 9 transfemoral osseointegration patients whose initial amputation was for TKA PJI management. Methods: A retrospective review of a prospectively maintained registry was conducted of 9 patients whose unilateral transfemoral osseointegration was performed following TKA PJI. Complications associated with the implantation of the titanium implant were noted, specifically antibiotic prescription or any additional surgery. K-level mobility performance before and after osseointegration was also compared. Results: Three patients (33.3%) had management for an infectious concern: 2 had a 10-day course of oral doxycycline for periportal drainage, and 1 had operative debridement with implant retention. No other complications (periprosthetic fracture, implant removal, and additional amputation) occurred. Eight patients (88.9%) improved their K-level, while 1 remained at K3. None declined. All achieved at least K2. Three patients were wheelchair-bound (K0) before osseointegration and achieved K3 or better. Conclusions: While infection may occur in patients who have TiTON following TKA PJI, our findings suggest that it does not seem inevitable, severe, or likely to further disable the patient. We noted meaningful mobility improvement that was common and lasting. Although our sample was small, we suggest that TiTON seems safe and reasonable to offer to patients seeking improved mobility and quality of life after amputation for TKA PJI management. Further study is warranted.
{"title":"Outcomes of Transfemoral Osseointegration for Patients With Prior Amputation to Manage Infected Total Knee Arthroplasty.","authors":"Tyler D DeSena, LaYow C Yu, S Robert Rozbruch, Taylor J Reif, Jidapa Wongcharoenwatana, Jason S Hoellwarth","doi":"10.1177/15563316251343034","DOIUrl":"10.1177/15563316251343034","url":null,"abstract":"<p><p><i>Background:</i> Management of total knee arthroplasty (TKA) periprosthetic joint infection (PJI) can prompt knee fusion or transfemoral amputation, both associated with poor mobility. The titanium transcutaneous osseointegrated nail (TiTON) provides superior mobility versus traditional socket prostheses but has been minimally studied for amputees with prior TKA PJI. <i>Purpose</i>: This study investigated the complications and mobility experience of 9 transfemoral osseointegration patients whose initial amputation was for TKA PJI management. <i>Methods</i>: A retrospective review of a prospectively maintained registry was conducted of 9 patients whose unilateral transfemoral osseointegration was performed following TKA PJI. Complications associated with the implantation of the titanium implant were noted, specifically antibiotic prescription or any additional surgery. K-level mobility performance before and after osseointegration was also compared. <i>Results</i>: Three patients (33.3%) had management for an infectious concern: 2 had a 10-day course of oral doxycycline for periportal drainage, and 1 had operative debridement with implant retention. No other complications (periprosthetic fracture, implant removal, and additional amputation) occurred. Eight patients (88.9%) improved their K-level, while 1 remained at K3. None declined. All achieved at least K2. Three patients were wheelchair-bound (K0) before osseointegration and achieved K3 or better. <i>Conclusions</i>: While infection may occur in patients who have TiTON following TKA PJI, our findings suggest that it does not seem inevitable, severe, or likely to further disable the patient. We noted meaningful mobility improvement that was common and lasting. Although our sample was small, we suggest that TiTON seems safe and reasonable to offer to patients seeking improved mobility and quality of life after amputation for TKA PJI management. Further study is warranted.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251343034"},"PeriodicalIF":1.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-17DOI: 10.1177/15563316251345479
Robert Koucheki, Johnathan R Lex, Michael Brock, Danny P Goel
Artificial intelligence (AI) and virtual reality (VR) are being used in orthopedic surgery, with goals of enhancing surgical precision, trainee education, patient engagement, and personalized surgical strategies. AI-based predictive modeling, automated computer vision and image analytics, and robotic surgery are changing orthopedic preoperative planning and intraoperative decision-making, with the ultimate aim of improving postoperative outcomes through reduced variability in surgery. VR technologies are being used in orthopedic surgical simulations to provide safe environments for skill development in surgical trainees, helping them practice complex procedures before performing live surgeries. VR platforms are also being studied in-patient rehabilitation, focusing on interactive and gamified approaches that could enhance patients' adherence, recovery, and outcomes. Major pitfalls and challenges that need to be addressed include technical and logistical barriers, ethical concerns surrounding patient data privacy, and resistance to change among surgeons, trainees, and scientists. Improved infrastructure, standardized protocols, and further research to validate the long-term benefits will be imperative for the integration of AI and VR technologies into clinical and surgical workflows.
{"title":"Integrating Artificial Intelligence and Virtual Reality in Orthopedic Surgery: A Comprehensive Review.","authors":"Robert Koucheki, Johnathan R Lex, Michael Brock, Danny P Goel","doi":"10.1177/15563316251345479","DOIUrl":"10.1177/15563316251345479","url":null,"abstract":"<p><p>Artificial intelligence (AI) and virtual reality (VR) are being used in orthopedic surgery, with goals of enhancing surgical precision, trainee education, patient engagement, and personalized surgical strategies. AI-based predictive modeling, automated computer vision and image analytics, and robotic surgery are changing orthopedic preoperative planning and intraoperative decision-making, with the ultimate aim of improving postoperative outcomes through reduced variability in surgery. VR technologies are being used in orthopedic surgical simulations to provide safe environments for skill development in surgical trainees, helping them practice complex procedures before performing live surgeries. VR platforms are also being studied in-patient rehabilitation, focusing on interactive and gamified approaches that could enhance patients' adherence, recovery, and outcomes. Major pitfalls and challenges that need to be addressed include technical and logistical barriers, ethical concerns surrounding patient data privacy, and resistance to change among surgeons, trainees, and scientists. Improved infrastructure, standardized protocols, and further research to validate the long-term benefits will be imperative for the integration of AI and VR technologies into clinical and surgical workflows.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251345479"},"PeriodicalIF":1.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-11DOI: 10.1177/15563316251344945
Gage Olson, Isabel Hansmann-Canas, Zahra Karimi, Amirhossein Yazdkhasti, Ghazal Shabestanipour, Hamid Ghaednia, Joseph H Schwab
As wearables are becoming an increasingly important part of wellness and everyday life for many people, their potential in healthcare is also expanding, particularly in personalized and remote healthcare. However, many wearables lack sophistication, relying on simple sensors such as accelerometers and pulse meters to measure heart rate, body composition, and daily activity. Such basic metrics are insufficient for musculoskeletal disease diagnosis, which requires more detailed, multimodal neuromusculoskeletal monitoring. A major challenge in wearables development is the need for precise electromechanical signal measurements, which are difficult to obtain with low-cost systems. Artificial intelligence (AI) holds promise in addressing these analytical challenges and enabling the creation of affordable, sophisticated wearables. While AI has been used for decades in engineering, its clinical application is still emerging, creating an opportunity for the development of AI-enhanced wearables capable of clinical diagnosis. AI can enhance data generated by various sensor types in wearable devices (such as accelerometers, electrical, optical, and acoustic sensors), enabling clinicians to monitor and diagnose complex conditions that require multiple sensing modalities. This review explores current wearable technologies, ongoing research in AI-enhanced wearables, the potential for AI to advance wearable technologies in healthcare, and the future directions in the development of multimodal wearables.
{"title":"The Impact of AI on the Development of Multimodal Wearable Devices in Musculoskeletal Medicine.","authors":"Gage Olson, Isabel Hansmann-Canas, Zahra Karimi, Amirhossein Yazdkhasti, Ghazal Shabestanipour, Hamid Ghaednia, Joseph H Schwab","doi":"10.1177/15563316251344945","DOIUrl":"10.1177/15563316251344945","url":null,"abstract":"<p><p>As wearables are becoming an increasingly important part of wellness and everyday life for many people, their potential in healthcare is also expanding, particularly in personalized and remote healthcare. However, many wearables lack sophistication, relying on simple sensors such as accelerometers and pulse meters to measure heart rate, body composition, and daily activity. Such basic metrics are insufficient for musculoskeletal disease diagnosis, which requires more detailed, multimodal neuromusculoskeletal monitoring. A major challenge in wearables development is the need for precise electromechanical signal measurements, which are difficult to obtain with low-cost systems. Artificial intelligence (AI) holds promise in addressing these analytical challenges and enabling the creation of affordable, sophisticated wearables. While AI has been used for decades in engineering, its clinical application is still emerging, creating an opportunity for the development of AI-enhanced wearables capable of clinical diagnosis. AI can enhance data generated by various sensor types in wearable devices (such as accelerometers, electrical, optical, and acoustic sensors), enabling clinicians to monitor and diagnose complex conditions that require multiple sensing modalities. This review explores current wearable technologies, ongoing research in AI-enhanced wearables, the potential for AI to advance wearable technologies in healthcare, and the future directions in the development of multimodal wearables.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251344945"},"PeriodicalIF":1.6,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-30DOI: 10.1177/15563316251340983
Kyle N Kunze, David Ferguson, Ayoosh Pareek, Nicholas Colyvas
Robotic-assisted surgery is now well-established in spine surgery and total joint arthroplasty, but its application to arthroscopy has only recently emerged in the context of advances in artificial intelligence (AI) and robotic technology. This new application addresses limitations of conventional arthroscopy, including constrained depth perception, variation in technique or anatomy leading to inaccuracies, manual fluid management adjustments, and limitations in dexterity due to the requirement that one hand is occupied by the arthroscope. Early preclinical and cadaveric studies demonstrate submillimeter precision and improved anatomic accuracy in procedures such as anterior cruciate ligament reconstruction, but widespread clinical adoption remains limited by regulatory, economic, and training hurdles. This review article synthesizes the capabilities and applications of current robotic-assisted arthroscopy platforms, surveys the landscape of available technologies, and examines barriers to adoption, thereby looking ahead to the potential use of this technology in redefining arthroscopic surgery.
{"title":"Robotic-Assisted Arthroscopy Promises Enhanced Procedural Efficiency, Visualization, and Control but Must Overcome Barriers to Adoption.","authors":"Kyle N Kunze, David Ferguson, Ayoosh Pareek, Nicholas Colyvas","doi":"10.1177/15563316251340983","DOIUrl":"10.1177/15563316251340983","url":null,"abstract":"<p><p>Robotic-assisted surgery is now well-established in spine surgery and total joint arthroplasty, but its application to arthroscopy has only recently emerged in the context of advances in artificial intelligence (AI) and robotic technology. This new application addresses limitations of conventional arthroscopy, including constrained depth perception, variation in technique or anatomy leading to inaccuracies, manual fluid management adjustments, and limitations in dexterity due to the requirement that one hand is occupied by the arthroscope. Early preclinical and cadaveric studies demonstrate submillimeter precision and improved anatomic accuracy in procedures such as anterior cruciate ligament reconstruction, but widespread clinical adoption remains limited by regulatory, economic, and training hurdles. This review article synthesizes the capabilities and applications of current robotic-assisted arthroscopy platforms, surveys the landscape of available technologies, and examines barriers to adoption, thereby looking ahead to the potential use of this technology in redefining arthroscopic surgery.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251340983"},"PeriodicalIF":1.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-30DOI: 10.1177/15563316251340303
Lulla V Kiwinda, Sophia D Kocher, Anna R Bryniarski, Christian A Pean
Artificial intelligence (AI) has emerged in orthopedics with the potential to improve diagnostic accuracy, optimize surgical workflows, and support personalized care. We conducted a narrative review exploring the bioethical considerations of AI use in the orthopedic clinical setting, focusing on 4 core principles-autonomy, beneficence, nonmaleficence, and justice-to provide orthopedists with a practical framework for AI's implementation. We utilized the Preferred Reporting Items for Systematic Reviews and Meta-Analyses framework to conduct a comprehensive PubMed search; 89 articles were evaluated and 23 met our inclusion criteria. Across these studies, bioethical considerations for the clinical implementation of AI tools consistently emerged, most commonly concerning privacy, bias, transparency, informed consent, and regulation. We offer recommendations for strengthening privacy safeguards, adopting bias mitigation strategies, improving transparency through explainable AI tools, and establishing clear regulatory frameworks with lifecycle evaluation.
{"title":"Bioethical Considerations of Deploying Artificial Intelligence in Clinical Orthopedic Settings: A Narrative Review.","authors":"Lulla V Kiwinda, Sophia D Kocher, Anna R Bryniarski, Christian A Pean","doi":"10.1177/15563316251340303","DOIUrl":"10.1177/15563316251340303","url":null,"abstract":"<p><p>Artificial intelligence (AI) has emerged in orthopedics with the potential to improve diagnostic accuracy, optimize surgical workflows, and support personalized care. We conducted a narrative review exploring the bioethical considerations of AI use in the orthopedic clinical setting, focusing on 4 core principles-autonomy, beneficence, nonmaleficence, and justice-to provide orthopedists with a practical framework for AI's implementation. We utilized the Preferred Reporting Items for Systematic Reviews and Meta-Analyses framework to conduct a comprehensive PubMed search; 89 articles were evaluated and 23 met our inclusion criteria. Across these studies, bioethical considerations for the clinical implementation of AI tools consistently emerged, most commonly concerning privacy, bias, transparency, informed consent, and regulation. We offer recommendations for strengthening privacy safeguards, adopting bias mitigation strategies, improving transparency through explainable AI tools, and establishing clear regulatory frameworks with lifecycle evaluation.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251340303"},"PeriodicalIF":1.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-30DOI: 10.1177/15563316251341321
Johannes Pawelczyk, Moritz Kraus, Sebastian Voigtlaender, Sebastian Siebenlist, Marco-Christopher Rupp
Artificial intelligence (AI) and digital health (DH) solutions are reshaping musculoskeletal (MSK) care across diagnostics, treatment planning, workflow optimization, and administrative burden reduction. AI-enabled triage systems enhance patient flow efficiency, while automated scheduling, symptom checkers, and AI-powered virtual assistants streamline pre-visit interactions. In MSK radiographic diagnostics, AI augments imaging interpretation, enabling automated fracture detection, opportunistic screening, and quantitative imaging, improving diagnostic accuracy and standardization. Preoperative planning solutions facilitate implant templating, surgical navigation, and patient-specific instrumentation, reducing variability and enhancing surgical precision. Concurrently, digital scribes and AI-driven documentation tools alleviate administrative overhead, mitigating clinician burnout and enabling refocused patient engagement. Predictive analytics optimize treatment pathways by leveraging multimodal patient data for risk stratification and personalized decision support. However, algorithmic bias, model generalizability, regulatory hurdles, and legal ambiguities present substantial implementation barriers, necessitating rigorous validation, adaptive governance, and seamless clinical integration. The U.S. and EU regulatory landscapes diverge in their approaches to AI oversight, with the former favoring expedited market access and the latter imposing stringent compliance mandates under the EU AI Act. AI's integration into MSK care demands robust validation frameworks, standardized interoperability protocols, and dynamic regulatory pathways balancing safety and innovation. Emerging generalist foundation models, open-source large language models (LLMs), and specialized AI-driven medical applications herald a paradigm shift toward precision MSK care. These innovations will require prospective clinical validation to ensure patient benefit and mitigate risk. Addressing ethical considerations, ensuring equitable access, and fostering interdisciplinary collaboration remain paramount in translating AI's potential into tangible improvements in MSK healthcare delivery.
人工智能(AI)和数字健康(DH)解决方案正在从诊断、治疗计划、工作流程优化和行政负担减轻等方面重塑肌肉骨骼(MSK)护理。支持人工智能的分诊系统提高了患者流程效率,而自动调度、症状检查器和人工智能驱动的虚拟助手简化了就诊前的互动。在MSK放射诊断中,人工智能增强了成像解释,实现了自动骨折检测、机会性筛查和定量成像,提高了诊断的准确性和标准化。术前计划解决方案有助于植入物模板、手术导航和患者特定的器械,减少可变性并提高手术精度。同时,数字抄写员和人工智能驱动的文档工具减轻了管理开销,减轻了临床医生的倦怠,并使患者重新关注。预测分析通过利用多模式患者数据进行风险分层和个性化决策支持来优化治疗途径。然而,算法偏差、模型可泛化性、监管障碍和法律模糊性构成了实质性的实施障碍,需要严格的验证、适应性治理和无缝的临床整合。美国和欧盟的监管格局在人工智能监管方面存在分歧,前者倾向于加快市场准入,后者则根据《欧盟人工智能法案》(EU AI Act)实施严格的合规要求。将人工智能集成到MSK护理中需要强大的验证框架、标准化的互操作性协议以及平衡安全和创新的动态监管途径。新兴的多面手基础模型、开源大型语言模型(llm)和专门的人工智能驱动的医疗应用预示着向精确MSK护理的范式转变。这些创新将需要前瞻性临床验证,以确保患者受益并降低风险。在将人工智能的潜力转化为MSK医疗保健服务的切实改进方面,解决伦理问题、确保公平获取和促进跨学科合作仍然至关重要。
{"title":"Advancing Musculoskeletal Care Using AI and Digital Health Applications: A Review of Commercial Solutions.","authors":"Johannes Pawelczyk, Moritz Kraus, Sebastian Voigtlaender, Sebastian Siebenlist, Marco-Christopher Rupp","doi":"10.1177/15563316251341321","DOIUrl":"10.1177/15563316251341321","url":null,"abstract":"<p><p>Artificial intelligence (AI) and digital health (DH) solutions are reshaping musculoskeletal (MSK) care across diagnostics, treatment planning, workflow optimization, and administrative burden reduction. AI-enabled triage systems enhance patient flow efficiency, while automated scheduling, symptom checkers, and AI-powered virtual assistants streamline pre-visit interactions. In MSK radiographic diagnostics, AI augments imaging interpretation, enabling automated fracture detection, opportunistic screening, and quantitative imaging, improving diagnostic accuracy and standardization. Preoperative planning solutions facilitate implant templating, surgical navigation, and patient-specific instrumentation, reducing variability and enhancing surgical precision. Concurrently, digital scribes and AI-driven documentation tools alleviate administrative overhead, mitigating clinician burnout and enabling refocused patient engagement. Predictive analytics optimize treatment pathways by leveraging multimodal patient data for risk stratification and personalized decision support. However, algorithmic bias, model generalizability, regulatory hurdles, and legal ambiguities present substantial implementation barriers, necessitating rigorous validation, adaptive governance, and seamless clinical integration. The U.S. and EU regulatory landscapes diverge in their approaches to AI oversight, with the former favoring expedited market access and the latter imposing stringent compliance mandates under the EU AI Act. AI's integration into MSK care demands robust validation frameworks, standardized interoperability protocols, and dynamic regulatory pathways balancing safety and innovation. Emerging generalist foundation models, open-source large language models (LLMs), and specialized AI-driven medical applications herald a paradigm shift toward precision MSK care. These innovations will require prospective clinical validation to ensure patient benefit and mitigate risk. Addressing ethical considerations, ensuring equitable access, and fostering interdisciplinary collaboration remain paramount in translating AI's potential into tangible improvements in MSK healthcare delivery.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251341321"},"PeriodicalIF":1.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}