Pub Date : 2025-05-30DOI: 10.1177/15563316251341321
Johannes Pawelczyk, Moritz Kraus, Sebastian Voigtlaender, Sebastian Siebenlist, Marco-Christopher Rupp
Artificial intelligence (AI) and digital health (DH) solutions are reshaping musculoskeletal (MSK) care across diagnostics, treatment planning, workflow optimization, and administrative burden reduction. AI-enabled triage systems enhance patient flow efficiency, while automated scheduling, symptom checkers, and AI-powered virtual assistants streamline pre-visit interactions. In MSK radiographic diagnostics, AI augments imaging interpretation, enabling automated fracture detection, opportunistic screening, and quantitative imaging, improving diagnostic accuracy and standardization. Preoperative planning solutions facilitate implant templating, surgical navigation, and patient-specific instrumentation, reducing variability and enhancing surgical precision. Concurrently, digital scribes and AI-driven documentation tools alleviate administrative overhead, mitigating clinician burnout and enabling refocused patient engagement. Predictive analytics optimize treatment pathways by leveraging multimodal patient data for risk stratification and personalized decision support. However, algorithmic bias, model generalizability, regulatory hurdles, and legal ambiguities present substantial implementation barriers, necessitating rigorous validation, adaptive governance, and seamless clinical integration. The U.S. and EU regulatory landscapes diverge in their approaches to AI oversight, with the former favoring expedited market access and the latter imposing stringent compliance mandates under the EU AI Act. AI's integration into MSK care demands robust validation frameworks, standardized interoperability protocols, and dynamic regulatory pathways balancing safety and innovation. Emerging generalist foundation models, open-source large language models (LLMs), and specialized AI-driven medical applications herald a paradigm shift toward precision MSK care. These innovations will require prospective clinical validation to ensure patient benefit and mitigate risk. Addressing ethical considerations, ensuring equitable access, and fostering interdisciplinary collaboration remain paramount in translating AI's potential into tangible improvements in MSK healthcare delivery.
人工智能(AI)和数字健康(DH)解决方案正在从诊断、治疗计划、工作流程优化和行政负担减轻等方面重塑肌肉骨骼(MSK)护理。支持人工智能的分诊系统提高了患者流程效率,而自动调度、症状检查器和人工智能驱动的虚拟助手简化了就诊前的互动。在MSK放射诊断中,人工智能增强了成像解释,实现了自动骨折检测、机会性筛查和定量成像,提高了诊断的准确性和标准化。术前计划解决方案有助于植入物模板、手术导航和患者特定的器械,减少可变性并提高手术精度。同时,数字抄写员和人工智能驱动的文档工具减轻了管理开销,减轻了临床医生的倦怠,并使患者重新关注。预测分析通过利用多模式患者数据进行风险分层和个性化决策支持来优化治疗途径。然而,算法偏差、模型可泛化性、监管障碍和法律模糊性构成了实质性的实施障碍,需要严格的验证、适应性治理和无缝的临床整合。美国和欧盟的监管格局在人工智能监管方面存在分歧,前者倾向于加快市场准入,后者则根据《欧盟人工智能法案》(EU AI Act)实施严格的合规要求。将人工智能集成到MSK护理中需要强大的验证框架、标准化的互操作性协议以及平衡安全和创新的动态监管途径。新兴的多面手基础模型、开源大型语言模型(llm)和专门的人工智能驱动的医疗应用预示着向精确MSK护理的范式转变。这些创新将需要前瞻性临床验证,以确保患者受益并降低风险。在将人工智能的潜力转化为MSK医疗保健服务的切实改进方面,解决伦理问题、确保公平获取和促进跨学科合作仍然至关重要。
{"title":"Advancing Musculoskeletal Care Using AI and Digital Health Applications: A Review of Commercial Solutions.","authors":"Johannes Pawelczyk, Moritz Kraus, Sebastian Voigtlaender, Sebastian Siebenlist, Marco-Christopher Rupp","doi":"10.1177/15563316251341321","DOIUrl":"10.1177/15563316251341321","url":null,"abstract":"<p><p>Artificial intelligence (AI) and digital health (DH) solutions are reshaping musculoskeletal (MSK) care across diagnostics, treatment planning, workflow optimization, and administrative burden reduction. AI-enabled triage systems enhance patient flow efficiency, while automated scheduling, symptom checkers, and AI-powered virtual assistants streamline pre-visit interactions. In MSK radiographic diagnostics, AI augments imaging interpretation, enabling automated fracture detection, opportunistic screening, and quantitative imaging, improving diagnostic accuracy and standardization. Preoperative planning solutions facilitate implant templating, surgical navigation, and patient-specific instrumentation, reducing variability and enhancing surgical precision. Concurrently, digital scribes and AI-driven documentation tools alleviate administrative overhead, mitigating clinician burnout and enabling refocused patient engagement. Predictive analytics optimize treatment pathways by leveraging multimodal patient data for risk stratification and personalized decision support. However, algorithmic bias, model generalizability, regulatory hurdles, and legal ambiguities present substantial implementation barriers, necessitating rigorous validation, adaptive governance, and seamless clinical integration. The U.S. and EU regulatory landscapes diverge in their approaches to AI oversight, with the former favoring expedited market access and the latter imposing stringent compliance mandates under the EU AI Act. AI's integration into MSK care demands robust validation frameworks, standardized interoperability protocols, and dynamic regulatory pathways balancing safety and innovation. Emerging generalist foundation models, open-source large language models (LLMs), and specialized AI-driven medical applications herald a paradigm shift toward precision MSK care. These innovations will require prospective clinical validation to ensure patient benefit and mitigate risk. Addressing ethical considerations, ensuring equitable access, and fostering interdisciplinary collaboration remain paramount in translating AI's potential into tangible improvements in MSK healthcare delivery.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251341321"},"PeriodicalIF":1.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-29DOI: 10.1177/15563316251340696
Romil Shah, Joseph H Schwab
Large language models (LLMs) offer potential applications across medical specialties; in spine surgery, opportunities exist to enhance patient care, streamline research, and improve clinical practice. This review explores the current and potential applications of LLMs in spine surgery, assessing their possibilities and limitations across patient education, research, clinical practice, and perioperative assistance.
{"title":"Large Language Models in Spine Surgery: A Promising Technology.","authors":"Romil Shah, Joseph H Schwab","doi":"10.1177/15563316251340696","DOIUrl":"10.1177/15563316251340696","url":null,"abstract":"<p><p>Large language models (LLMs) offer potential applications across medical specialties; in spine surgery, opportunities exist to enhance patient care, streamline research, and improve clinical practice. This review explores the current and potential applications of LLMs in spine surgery, assessing their possibilities and limitations across patient education, research, clinical practice, and perioperative assistance.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251340696"},"PeriodicalIF":1.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-28DOI: 10.1177/15563316251339660
Miguel M Girod, Sami Saniei, Marisa N Ulrich, Lainey G Bukowiec, Kellen L Mulford, Michael J Taunton, Cody C Wyles
As artificial intelligence (AI) advances in healthcare, encompassing robust applications for the diagnosis and prognostication of musculoskeletal diseases, clinicians must increasingly understand the implications of machine learning and deep learning in their practice. This review article explores computer vision algorithms and patient-specific, multimodal prediction models; provides a simple framework to guide discussion on the limitations of AI model development; and introduces the field of generative AI.
{"title":"Artificial Intelligence in the Diagnosis and Prognostication of the Musculoskeletal Patient.","authors":"Miguel M Girod, Sami Saniei, Marisa N Ulrich, Lainey G Bukowiec, Kellen L Mulford, Michael J Taunton, Cody C Wyles","doi":"10.1177/15563316251339660","DOIUrl":"10.1177/15563316251339660","url":null,"abstract":"<p><p>As artificial intelligence (AI) advances in healthcare, encompassing robust applications for the diagnosis and prognostication of musculoskeletal diseases, clinicians must increasingly understand the implications of machine learning and deep learning in their practice. This review article explores computer vision algorithms and patient-specific, multimodal prediction models; provides a simple framework to guide discussion on the limitations of AI model development; and introduces the field of generative AI.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251339660"},"PeriodicalIF":1.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-28DOI: 10.1177/15563316251341229
Mitchell A Johnson, Tyler Khilnani, Abigail Hyun, Troy B Amen, Nathan H Varady, Benedict U Nwachukwu, Joshua S Dines
Telemedicine has become an increasingly important component of musculoskeletal care, with recent advances in virtual physical examinations, enhanced patient education, and expanded access to treatment and telerehabilitation. Emerging applications of artificial intelligence, including virtual triaging and remote patient monitoring, promise to further augment telemedicine's effectiveness and scope. Despite limitations and a continued preference for in-person visits among some patients, telemedicine can be a valuable tool for musculoskeletal health practitioners, offering new ways to deliver high-quality, timely, and cost-effective care.
{"title":"The State of Telemedicine, Telerehabilitation, and Virtual Care in Musculoskeletal Health: A Narrative Review.","authors":"Mitchell A Johnson, Tyler Khilnani, Abigail Hyun, Troy B Amen, Nathan H Varady, Benedict U Nwachukwu, Joshua S Dines","doi":"10.1177/15563316251341229","DOIUrl":"10.1177/15563316251341229","url":null,"abstract":"<p><p>Telemedicine has become an increasingly important component of musculoskeletal care, with recent advances in virtual physical examinations, enhanced patient education, and expanded access to treatment and telerehabilitation. Emerging applications of artificial intelligence, including virtual triaging and remote patient monitoring, promise to further augment telemedicine's effectiveness and scope. Despite limitations and a continued preference for in-person visits among some patients, telemedicine can be a valuable tool for musculoskeletal health practitioners, offering new ways to deliver high-quality, timely, and cost-effective care.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251341229"},"PeriodicalIF":1.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-28DOI: 10.1177/15563316251340074
Romil Shah, Kevin J Bozic, Prakash Jayakumar
Artificial intelligence (AI) presents new opportunities to advance value-based healthcare in orthopedic surgery through 3 potential mechanisms: agency, automation, and augmentation. AI may enhance patient agency through improved health literacy and remote monitoring while reducing costs through triage and reduction in specialist visits. In automation, AI optimizes operating room scheduling and streamlines administrative tasks, with documented cost savings and improved efficiency. For augmentation, AI has been shown to be accurate in diagnostic imaging interpretation and surgical planning, while enabling more precise outcome predictions and personalized treatment approaches. However, implementation faces substantial challenges, including resistance from healthcare professionals, technical barriers to data quality and privacy, and significant financial investments required for infrastructure. Success in healthcare AI integration requires careful attention to regulatory frameworks, data privacy, and clinical validation.
{"title":"Artificial Intelligence in Value-Based Health Care.","authors":"Romil Shah, Kevin J Bozic, Prakash Jayakumar","doi":"10.1177/15563316251340074","DOIUrl":"10.1177/15563316251340074","url":null,"abstract":"<p><p>Artificial intelligence (AI) presents new opportunities to advance value-based healthcare in orthopedic surgery through 3 potential mechanisms: agency, automation, and augmentation. AI may enhance patient agency through improved health literacy and remote monitoring while reducing costs through triage and reduction in specialist visits. In automation, AI optimizes operating room scheduling and streamlines administrative tasks, with documented cost savings and improved efficiency. For augmentation, AI has been shown to be accurate in diagnostic imaging interpretation and surgical planning, while enabling more precise outcome predictions and personalized treatment approaches. However, implementation faces substantial challenges, including resistance from healthcare professionals, technical barriers to data quality and privacy, and significant financial investments required for infrastructure. Success in healthcare AI integration requires careful attention to regulatory frameworks, data privacy, and clinical validation.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251340074"},"PeriodicalIF":1.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-28DOI: 10.1177/15563316251337359
David Figueroa, Luis Moya, José Arteaga, Alex Vaisman, Mathias Bostrom, Carolina Acuña, Domenico Alesi, Fernando Radice, Francisco Figueroa, Felipe Toro, Meir Liebergall, Mark Stegeman, Magnus Tagil, Mario Lenza, Parag Sancheti, Amar Ranawat, Rafael Calvo, Rodrigo Guiloff, Laura Robbins, Sebastian Irarrazaval, Stefano Zaffagnini, Tobias Jung, Tobias Winkler
{"title":"Orthopedic Residency Programs: What are Our Current Goals? An International Society of Orthopedic Centers (ISOC) Delphi Consensus.","authors":"David Figueroa, Luis Moya, José Arteaga, Alex Vaisman, Mathias Bostrom, Carolina Acuña, Domenico Alesi, Fernando Radice, Francisco Figueroa, Felipe Toro, Meir Liebergall, Mark Stegeman, Magnus Tagil, Mario Lenza, Parag Sancheti, Amar Ranawat, Rafael Calvo, Rodrigo Guiloff, Laura Robbins, Sebastian Irarrazaval, Stefano Zaffagnini, Tobias Jung, Tobias Winkler","doi":"10.1177/15563316251337359","DOIUrl":"10.1177/15563316251337359","url":null,"abstract":"","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251337359"},"PeriodicalIF":1.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-20DOI: 10.1177/15563316251341314
Kyle N Kunze
{"title":"Artificial Intelligence and Digital Applications in Musculoskeletal Healthcare: Ready or Not, Here It Comes!","authors":"Kyle N Kunze","doi":"10.1177/15563316251341314","DOIUrl":"10.1177/15563316251341314","url":null,"abstract":"","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251341314"},"PeriodicalIF":1.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-20DOI: 10.1177/15563316251340697
Burak Tayyip Dede, Muhammed Oğuz, Bülent Alyanak, Fatih Bağcıer, Mustafa Turgut Yıldızgören
Background:The proliferation of artificial intelligence has led to widespread patient use of large language models (LLMs). Purpose: We sought to characterize LLM responses to questions about piriformis syndrome (PS). Methods: On August 15, 2024, we asked 3 LLMs-ChatGPT-4, Copilot, and Gemini-to respond to the 25 most frequently asked questions about PS, as tracked by Google Trends. We evaluated the accuracy and completeness of the responses according to the Likert scale. We used the Ensuring Quality Information for Patients (EQIP) tool to assess the quality of the responses and assessed readability using Flesch-Kincaid Reading Ease (FKRE) and Flesch-Kincaid Grade Level (FKGL) scores. Results: The mean completeness scores of the responses obtained from ChatGPT, Copilot, and Gemini were 2.8 ± 0.3, 2.2 ± 0.6, and 2.6 ± 0.4, respectively. There was a significant difference in the mean completeness score among LLMs. In pairwise comparisons, ChatGPT and Gemini were superior to Copilot. There was no significant difference between the LLMs in terms of mean accuracy scores. In readability analyses, no significant difference was found in terms of FKRE scores. However, a significant difference was found in FKGL scores. A significant difference between LLMs was identified in the quality analysis performed according to EQIP scores. Conclusion: Although the use of LLMs in healthcare is promising, our findings suggest that these technologies need to be improved to perform better in terms of accuracy, completeness, quality, and readability on PS for a general audience.
{"title":"Competencies of Large Language Models About Piriformis Syndrome: Quality, Accuracy, Completeness, and Readability Study.","authors":"Burak Tayyip Dede, Muhammed Oğuz, Bülent Alyanak, Fatih Bağcıer, Mustafa Turgut Yıldızgören","doi":"10.1177/15563316251340697","DOIUrl":"10.1177/15563316251340697","url":null,"abstract":"<p><p><i>Background:</i>The proliferation of artificial intelligence has led to widespread patient use of large language models (LLMs). <i>Purpose</i>: We sought to characterize LLM responses to questions about piriformis syndrome (PS). <i>Methods</i>: On August 15, 2024, we asked 3 LLMs-ChatGPT-4, Copilot, and Gemini-to respond to the 25 most frequently asked questions about PS, as tracked by Google Trends. We evaluated the accuracy and completeness of the responses according to the Likert scale. We used the Ensuring Quality Information for Patients (EQIP) tool to assess the quality of the responses and assessed readability using Flesch-Kincaid Reading Ease (FKRE) and Flesch-Kincaid Grade Level (FKGL) scores. <i>Results</i>: The mean completeness scores of the responses obtained from ChatGPT, Copilot, and Gemini were 2.8 ± 0.3, 2.2 ± 0.6, and 2.6 ± 0.4, respectively. There was a significant difference in the mean completeness score among LLMs. In pairwise comparisons, ChatGPT and Gemini were superior to Copilot. There was no significant difference between the LLMs in terms of mean accuracy scores. In readability analyses, no significant difference was found in terms of FKRE scores. However, a significant difference was found in FKGL scores. A significant difference between LLMs was identified in the quality analysis performed according to EQIP scores. <i>Conclusion</i>: Although the use of LLMs in healthcare is promising, our findings suggest that these technologies need to be improved to perform better in terms of accuracy, completeness, quality, and readability on PS for a general audience.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251340697"},"PeriodicalIF":1.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-20DOI: 10.1177/15563316251339596
Felix C Oettl, Bálint Zsidai, Jacob F Oeding, Kristian Samuelsson
Artificial intelligence (AI) has emerged as a transformative force in orthopedic surgery. Potentially encompassing pre-, intra-, and postoperative processes, it can process complex medical imaging, provide real-time surgical guidance, and analyze large datasets for outcome prediction and optimization. AI has shown improvements in surgical precision, efficiency, and patient outcomes across orthopedic subspecialties, and large language models and agentic AI systems are expanding AI utility beyond surgical applications into areas such as clinical documentation, patient education, and autonomous decision support. The successful implementation of AI in orthopedic surgery requires careful attention to validation, regulatory compliance, and healthcare system integration. As these technologies continue to advance, maintaining the balance between innovation and patient safety remains crucial, with the ultimate goal of achieving more personalized, efficient, and equitable healthcare delivery while preserving the essential role of human clinical judgment. This review examines the current landscape and future trajectory of AI applications in orthopedic surgery, highlighting both technological advances and their clinical impact. Studies have suggested that AI-assisted procedures achieve higher accuracy and better functional outcomes compared to conventional methods, while reducing operative times and complications. However, these technologies are designed to augment rather than replace clinical expertise, serving as sophisticated tools to enhance surgeons' capabilities and improve patient care.
{"title":"Artificial Intelligence and Musculoskeletal Surgical Applications.","authors":"Felix C Oettl, Bálint Zsidai, Jacob F Oeding, Kristian Samuelsson","doi":"10.1177/15563316251339596","DOIUrl":"10.1177/15563316251339596","url":null,"abstract":"<p><p>Artificial intelligence (AI) has emerged as a transformative force in orthopedic surgery. Potentially encompassing pre-, intra-, and postoperative processes, it can process complex medical imaging, provide real-time surgical guidance, and analyze large datasets for outcome prediction and optimization. AI has shown improvements in surgical precision, efficiency, and patient outcomes across orthopedic subspecialties, and large language models and agentic AI systems are expanding AI utility beyond surgical applications into areas such as clinical documentation, patient education, and autonomous decision support. The successful implementation of AI in orthopedic surgery requires careful attention to validation, regulatory compliance, and healthcare system integration. As these technologies continue to advance, maintaining the balance between innovation and patient safety remains crucial, with the ultimate goal of achieving more personalized, efficient, and equitable healthcare delivery while preserving the essential role of human clinical judgment. This review examines the current landscape and future trajectory of AI applications in orthopedic surgery, highlighting both technological advances and their clinical impact. Studies have suggested that AI-assisted procedures achieve higher accuracy and better functional outcomes compared to conventional methods, while reducing operative times and complications. However, these technologies are designed to augment rather than replace clinical expertise, serving as sophisticated tools to enhance surgeons' capabilities and improve patient care.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251339596"},"PeriodicalIF":1.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-01Epub Date: 2025-01-08DOI: 10.1177/15563316241308265
Elizabeth Brown, Samantha A Mohler, Shiloah A Kviatkovsky, Lindsay E Blake, J Ryan Hill, Jeffrey B Stambough, Paul M Inclan
Background: Essential amino acid (EAA) supplementation, including conditionally essential amino acid (CEAA) and branched-chain amino acids (BCAA) supplementation, has been suggested as a mechanism to optimize patient outcomes by counteracting the atrophy associated with orthopedic procedures. Purpose: We sought to investigate the effect of EAA supplementation in the perioperative period on patients undergoing orthopedic and spine surgery, specifically whether it is associated with (1) reductions in postoperative muscle atrophy and (2) improved postoperative function including range of motion, strength, and mobility. Methods: We conducted a systematic review of the literature. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used, and the protocol was registered in the Prospective Register of Systematic Reviews (PROSPERO) database (CRD42023447774). Studies of interest were prospective, placebo-controlled, randomized clinical trials (RCTs) published between 2002 and 2023 evaluating the impact of EAA supplementation on patients undergoing orthopedic and spine surgery. Results: Ten RCTs evaluating EAA supplementation in trauma, adult reconstruction, and spine surgery were identified; half of these focused on adult reconstruction. The EAA supplementation dose (3.4-20 g), frequency (daily to 3 times per day), and duration (14-49 days) varied widely across studies. Seven studies reported parameters relating to muscle size and/or composition, with 3 studies reporting superior muscle size/composition in patients receiving perioperative EAA supplementation, when compared with controls. Three studies reported favorable mobility outcomes for patients receiving EAA. Meta-analysis was prohibited by variation in measurement and outcome variables across the studies. Conclusions: Pooled data from level I studies supports the use of EAA, BCAA, and CEAA supplementations across several orthopedic subspecialties. However, significant heterogeneity exists in the quantity, duration, and content of EAA administered. Further prospective studies are needed to determine optimal/standardized parameters for supplementation.
{"title":"Amino Acid Supplementation May Help Prevent Muscle Wasting After Orthopedic Surgery, but Additional Studies Are Warranted: A Systematic Review of Randomized Clinical Trials.","authors":"Elizabeth Brown, Samantha A Mohler, Shiloah A Kviatkovsky, Lindsay E Blake, J Ryan Hill, Jeffrey B Stambough, Paul M Inclan","doi":"10.1177/15563316241308265","DOIUrl":"10.1177/15563316241308265","url":null,"abstract":"<p><p><i>Background:</i> Essential amino acid (EAA) supplementation, including conditionally essential amino acid (CEAA) and branched-chain amino acids (BCAA) supplementation, has been suggested as a mechanism to optimize patient outcomes by counteracting the atrophy associated with orthopedic procedures. <i>Purpose:</i> We sought to investigate the effect of EAA supplementation in the perioperative period on patients undergoing orthopedic and spine surgery, specifically whether it is associated with (1) reductions in postoperative muscle atrophy and (2) improved postoperative function including range of motion, strength, and mobility. <i>Methods:</i> We conducted a systematic review of the literature. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used, and the protocol was registered in the Prospective Register of Systematic Reviews (PROSPERO) database (CRD42023447774). Studies of interest were prospective, placebo-controlled, randomized clinical trials (RCTs) published between 2002 and 2023 evaluating the impact of EAA supplementation on patients undergoing orthopedic and spine surgery. <i>Results:</i> Ten RCTs evaluating EAA supplementation in trauma, adult reconstruction, and spine surgery were identified; half of these focused on adult reconstruction. The EAA supplementation dose (3.4-20 g), frequency (daily to 3 times per day), and duration (14-49 days) varied widely across studies. Seven studies reported parameters relating to muscle size and/or composition, with 3 studies reporting superior muscle size/composition in patients receiving perioperative EAA supplementation, when compared with controls. Three studies reported favorable mobility outcomes for patients receiving EAA. Meta-analysis was prohibited by variation in measurement and outcome variables across the studies. <i>Conclusions:</i> Pooled data from level I studies supports the use of EAA, BCAA, and CEAA supplementations across several orthopedic subspecialties. However, significant heterogeneity exists in the quantity, duration, and content of EAA administered. Further prospective studies are needed to determine optimal/standardized parameters for supplementation.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"200-210"},"PeriodicalIF":1.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11713956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}