THE NEW ARMENIAN MEDICAL JOURNAL最新文献

{"title":"Effectiveness of platelet indices in predicting type 2 diabetes mellitus microvascular complications","authors":"K. Ashwani, R. Raghavendra, B. Sujatha","doi":"10.56936/18290825-2022.16.2-118","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.2-118","url":null,"abstract":"Objective - This study was conducted to evaluate the efficacy of platelet indices, namely mean platelet volume, platelet distribution width, plateletcrit and platelet count for prediction of microvascular complications of type 2 diabetes mellitus.\u0000Methods - A hospital-based, single-centre, observational, matched case-control study was conducted. A total of 120 diabetic cases and 120 non-diabetic controls were recruited and various biochemical parameters (fasting and post-prandial blood glucose, HbA1c, mean platelet volume, platelet distribution width, plateletcrit, platelet count and others) were measured. All diabetic cases were subjected for diagnosis of retinopathy, nephropathy or neuropathy. Statistical analyses were performed using unpaired t-test and Pearson’s correlation test.\u0000Results - The mean (±SD) age of the diabetic cases and controls were 59.8 (±11.2) years and 53.61 (±10.66) years, respectively. The overall male:female distribution was 64.2%:35.8% and 55.8%:44.2% in diabetic cases and controls, respectively. Platelet count and plateletcrit were found to be significantly higher in diabetic cases than controls (288741 (±97447)/µL vs. 255041 (±63883)/µL, p-value = 0.002; 0.234±0.072% vs. 0.201±0.043%, p-value = 0.0002). However, mean platelet volume and platelet distribution width in diabetic cases were not found to be significantly changed when compared to controls. Plateletcrit showed positive correlation with HbA1c with Pearson’s correlation coefficient of r=0.19 (p-value <0.05). Mean platelet volume and platelet distribution width were found to be not-significantly correlated with HbA1c. Among diabetics, only plateletcrit was found to be significantly raised in cases with all complications compared to cases with no complication (p-value <0.05). \u0000Conclusion - Plateletcrit and platelet count were found to be efficacious in forecasting the microvascular complications in type 2 diabetes.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123148915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of marginal adaptation of (CAD/CAM) Lava plus high translucent zirconia and (CAD/CAM) IPS-Emax Full Crowns","authors":"J.A. Bassel, M.S. Eyad","doi":"10.56936/18290825-2022.16.1-70","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.1-70","url":null,"abstract":"The purpose of this research to compare the internal and marginal fit of two full crown’s materials made by (Cad/Cam) machine “lava plus high translucent zirconia and Ips-Emax using replica technique.\u0000The research sample consisted of 60 premolars prepared to have a full crown and it was divided into two equal groups (n1=n2=30), in the first group the full crowns were fabricated by Lava Plus high translucent zirconia whereas in the second group the full crowns were fabricated by IPS-Emax.\u0000Marginal adaptation of the crowns was measured by (cement replica technique) before applying the cementation steps of crowns, gingivo-incisal sections and mesio-distal sections were made and measured the marginal adaptation in 3 points in the cervical area and 3 points in the contact area using the BX41 OLYMPUS optical microscope magnifying ×10. Normal distribution of data was confirmed by using Kolmogorov-Smirnov test, then data analysis was done using Independent samples t-test at significance level of (α=0.05).\u0000The average marginal gap of the Lava Plus and IPS-Emax full crowns were 105.72 and 152.57 micron respectively, therefor there is a statistically significant difference at 95% confidence level (p<0.05), the average marginal gap value of the second group was higher than the first group by (46.85 micron).\u0000Among the limitations of this study we conclude that the marginal gap value of the full crowns varies according to the material which they were fabricated by it, Thus, LAVA Pluas high translucent zirconia Full crowns have more adaptation than Ips-Emax Full crowns as it represents less marginal gap values, although all values were within clinically acceptable limits.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"110 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128281818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feature analysis of computed tomographic signs of hepatocellular carcinoma in multiphase studies","authors":"ArmeNiAN medicAl JourNAl, issaMatoV B.k, Zholdybay Zh.Zh., tajiBaeV t.k, serikuly e.s, BaiMakhanoV B.B, Medeubekov U.Sh., saGatoV i.y","doi":"10.56936//18290825-2022.16.1-23","DOIUrl":"https://doi.org/10.56936//18290825-2022.16.1-23","url":null,"abstract":"Hepatocellular carcinoma is one of the actual problems in the structure of oncological pathology in the world and in Kazakhstan. In the diagnosis of hepatocellular carcinoma, the use of multiphase computed tomography is generally accepted. The article describes the analysis of the results of multiphase computer tomography with the correlation of cytological and histological studies in the diagnosis of hepatocellular carcinoma. \u0000Present study aimed to conduct a retrospective analysis of the results of multiphase computer tomography in patients with hepatocellular carcinoma\u0000Analyzed the archival data of 50 patients with malignant liver tumors, who received specialized treatment at the A.N. Syzganov National scientific center of surgery and Kazakh Scientific Research Institute of Oncology and Radiology in the period 2014 - 2017. All patients underwent multiphase computed tomography. The examination was carried out in 4 phases: native, arterial, port-venous and delayed. The scan was performed on the 30th, 60th and 120 second (respectively) after the administration of contrast agent. \u0000The nodular form was detected in 76% of cases. If in 60% of cases the tumor was localized in the right lobe of the liver, and in 18% of cases - in the left, the lesion of both lobes was observed in 22% of cases. The sizes of the tumors were from 1 cm to 21.1 cm, and the average size of all nodes was 10.6 cm. The outlines of the tumors were uneven, but clearly defined in 92% of cases. In 94% of cases, the density of the formations was hypodense, the structure was heterogeneous with areas of increased and decreased density. The presence of central necrosis in the form of an “asterisk” was visualized in 8% of cases. The non-intensive inhomogeneous hyperenhancement in the arterial phase, with complete “washout” into the porto-venous phase, as well as in the porto-venous and delayed phases, was observed in 6% and 12% cases, respectively. In 80% of cases, hyperenhancement was observed in the arterial and venous phases. At the same time, complete erosion in the delayed phase was observed in 60% of cases, and incomplete leaching - 20%. In cytological studies, hepatocellular carcinoma was confirmed in 69.7% of cases. In 93.1% of cases, hepatocellular carcinoma was confirmed in histological studies. \u0000The nodes of hepatocellular carcinoma in most cases were characterized by clear, uneven contours, hypodense density, heterogeneous structure due to foci of necrosis and cystic component. When the tumor was bolus contrasted, hyperenhancement was in the arterial and port-venous phases, with “washout” in the delayed phase in most cases. According to the received data it can be said that multiphase computed tomography has high information value in the diagnosis of hepatocellular carcinoma.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130889904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of acute diarrhea by community pharmacies","authors":"L. Nazaryan, A. Barseghyan, M. Simonyan","doi":"10.56936/18290825-2022.16.3-107","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.3-107","url":null,"abstract":"Pharmacists are the most accessible healthcare professionals and they are often involved in managing diarrhea symptom. \u0000Aim of the study was to evaluate the practices of Republic of Armenia pharmacy employees when managing diarrhea, with specific focus on medicine dispensing, pharmaceutical care and also consumer preferences about medicines. The survey was conducted among 284 pharmacy employees selected randomly sampling during 2019-2021. Primary information was collected using a questionnaire. Pharmacy employee in Armenia was asked about their knowledge and dispensing recommendations to manage diarrhea. On each question is attached diagram or table. The results were analyzed with SPSS statistical software, version 12.0. \u0000Diarrhea is considered a common symptom, about which patients very often seek the advice of a pharmacy staff. Pharmacy employees dispense a large number of drugs for diarrhea every day. The most common medicines recommended by them were Antimotelities, then Probiotics, Intestinal adsorbent, Antibiotics, Oral rehydration solutions and Antimicrobial. The most common demanded medicines by consumers were also Antimotelity medicines, Antibiotics, then Probiotics, Intestinal adsorbent, oral rehydration solutions and Antimicrobial. Pharmaceutical advice given by pharmacy staff on medicine use and side effects was poor. In question what are the major side effects of medicines you are offered, most pharmacy staff (55%) did not respond, 20% of pharmacy employees noted side effects on the gastrointestinal system, 7% on the nervous system. 8% of pharmacy employees noted allergic reaction and 10% other different side effects. According to the study, the majority of pharmacy employees receive information about over-the-counter drugs of for diarrhea from sources on the Internet. Only few participants used formularies, standard tables, professional books and lectures.\u0000It is important to improve pharmacy employees’ knowledge in the area of Pharmaceutical care during minor illnesses such as diarrhea and to develop pharmaceutical care algorithms that will help the pharmacy employees in consumer consultation.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134109548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Covid-19 infection and Buerger`s syndrome: A case report","authors":"A. Hovhannisyan, V. Asoyan, N. Gyulazyan, A.A. Madatyan, A.H. Poghosyan, M. Mohammadi, E.S. Barseghyan","doi":"10.56936/18290825-2022.16.2-33","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.2-33","url":null,"abstract":"COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the recent global pandemic, with increasing number of cases reported globally. Our understanding of this novel respiratory virus deepens, it is increasingly clear that its effects extend beyond that of the respiratory system and can be extended to the almost all organ systems. SARS-CoV-2 causes lung inflammation which progresses to cytokine storm in the most severe cases. The lungs of patients with COVID-19 show extensive alveolar and interstitial inflammation. COVID-19 causes a spectrum of complications, with frequent involvement of the hemostatic system and there is a high incidence of venous thromboembolism in hospitalized COVID-19 patients, particularly those with severe illness. There is evidence of current body knowledge that COVID-19 induced by microvascular angiopathy can lead to a wide range of tissue pathology and clinical complications, such as Kawasaki disease, Buerger’s syndrome and other systemic inflammatory disorders. Thromboangiitis obliterans (TAO) or Buerger’s disease is a segmental occlusive inflammatory condition of arteries and veins, characterized by thrombosis and recanalization of the affected vessels. Limb infection at diagnosis was associated with a 4-fold higher risk of amputation. Smoking cessation was strongly associated with a lower rate of vascular events and amputation. TAO appears more likely to be a systemic disorder rather than a localized vasculopathy. Therefore, treatment protocols based on systemic treatment of TAO patients may be more helpful than localized treatment, such as bypass surgery and endovascular procedures.\u0000We present a case of a 53-years-old male with positive SARS-CoV-2 PCR test. Furter examination showed that patient had pneumonia, moreover, based on the duplex scan results the diagnosis of thromboangiitis obliterans (TAO) or Buerger’s disease was confirmed. This disease itself is associated with a high risk of thrombosis and alongside with COVID-19 can cause unpredictable outcome. Patient underwent the day-round observation, received the appropriate treatment and was successfully discharged from the hospital on the day 11.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132170394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical treatment of aneurysms of aortic arch branches and vessels of the upper extremities","authors":"M. Khanchi, A. Matkerimov, A. Tergeussizov, T. Demeuov, M. Zhakubayev, M. Khanchi, A. Shamshiev, I. Sagatov","doi":"10.56936/18290825-2022.16.1-35","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.1-35","url":null,"abstract":"Aneurysms of theaortic arch branches and vessels of the upper extremities are dangerous and there is a high probability of mortality due to rupture of the aneurysm or stroke. The indication is surgical treatment, regardless of the age and size of the aneurysms. The frequency of deaths and strokes that occurred during operations for carotid artery aneurysms is about 2%, which is associated with distal embolism of intracerebral vessels and the contents of the aneurysm cavity.\u0000One of the most common causes of aneurysms of the branches of the aortic arch and vessels of the upper extremities are atherosclerosis, nonspecific aortoarteritis and posttraumatic aneurysms.\u0000The study included 38 patients with aneurysms of the branches of the aortic arch and arteries of the upper extremities operated in the vascular surgery department over the past 10 years, whose total age ranged from 19 to 76 years. There were 84% men, 16% women. Aneurysms of the carotid arteries and its branches (temporal artery) were diagnosed in 58%, subclavian arteries in 16%, arteries of the upper extremities in 26%.\u0000The size of aneurysms of the branches of the aortic arch and arteries of the upper extremities ranged from 2.5 cm to 10 cm. The average size is 6.3±1.8 cm.\u0000When choosing the method of treatment of aneurysms of the branches of the aortic arch and arteries of the upper extremities, preference was given to performing reconstructive operations without the use of additional materials, which were performed in 52% cases), in 13 of these cases, excision of a false aneurysm with stitching of the defect was performed, in 6 of these cases, resections of aneurysms with end-to-end anastomosis were performed. In 48% cases, operations with the use of synthetic materials and autovenous plastic surgery were performed, and endovascular interventions were also performed in 4 cases.\u0000The most frequent type of surgery performed is resection of an aneurysm with a lateral suture – 34% cases. Resection of the anastomosis aneurysm at the end of the arteries – 16%, and prosthetics – in 8% cases (synthetic alloprosthetics in one and with autovenous prosthetics in two cases). After resection of subclavian artery aneurysm due to large diastasis of blood flow, reconstruction was performed by bypass surgery or prosthetics. Arterial aneurysm resection with autovenous patch was performed in 13% cases, and with allosunting – in 8% cases. Excision of an aneurysm of the axillary artery on the left with the restoration of a synthetic patch – in 5% cases. Ligation of an aneurysm in the temporal artery was performed in 2 cases (5%), this type of operation was performed with an aneurysm of non-main vessels, as well as in vessels with collateral blood flow in the distal area of the vessels. Implantation of a stentgraft into the right subclavian artery – in 3 cases (8%). X-ray endovascular embolization of aneurysm – in 3% case.\u0000Positive results in the postoperative period were observed in 92% patients. One (3%) pat","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130428082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temperature effect on thermal changes and phase analysis of 3Y-TZP zirconia restorations","authors":"O. Mordanov, Z. Khabadze, D. Nazarova, E. Shilyaeva, A. Kotelnikova, A. Mordanova","doi":"10.56936/18290825-2022.16.1-64","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.1-64","url":null,"abstract":"This study aimed to investigate the effect of final sintering on the thermal properties and phase composition of yttrium-stabilized zirconium dioxide.\u0000Totally 15 yttrium-stabilized zirconium oxide standard ovoid samples were studied (3Y-TZP, IPS e.max ZirCAD LT, Ivoclar Vivadent, Schaan, Liechtenstein). This material contains the following components: ZrO2 - 87.0 - 95.0%, Y2O3 - 4.0 - 6.0%, HfO2 - 1.0 - 5.0%, Al2O3 - 0.0 - 1, 0%. Initially, X-ray diffraction analysis was performed. After that, differential scanning calorimetry was carried out up to a temperature of 900°C. X-ray diffraction analysis was performed to assess the effect of the firing process on the phase analysis of zirconia samples (Selected samples were tested on an X-ray diffraction instrument (EMPYREAN, PANalytical, Lelyweg, The Netherlands) The thermal changes study in zirconia samples resulting from repetitive firing processes was performed then. Samples were placed in a differential scanning calorimeter (NETZSCH STA 409 PC Luxx, Bavaria, Germany) and heated at a rate of 10°C/min from 50°C to 900°C.) Then, differential scanning calorimetry data (the mass and structural changes of zirconia samples depending on temperature) was recorded.\u0000The percentage of the monoclinic phase increases on average from 3.6% to 7.5%, but this difference is not statistically significant (p=0.1). Two exothermic peaks were observed when the samples were heated from 50°C to 900°C.\u0000The final firing of 3Y-TZP zirconium crown up to 900°C slightly increases the content of the monoclinic phase and causes exothermal changes.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115600916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Achievements and challenges of management of Covid-19 patients at Mikaelyan University Hospital","authors":"A. Hovhannisyan, V. Asoyan, M. Shmavonyan, L. Harutyunyan, M.H. Torosyan, T.V. Ayvazyan, A. Ghazaryan, E.S. Barseghyan, A. Muradyan","doi":"10.56936/18290825-2022.16.4-31","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.4-31","url":null,"abstract":"More than two years since the first SARS-CoV-2 infection were reported, the COVID-19 pandemic remains an acute global emergency. The COVID-19 pandemic has deeply affected the lives of people across the world. Its health, economic, political, educational, and societal consequences have disproportionately affected the most vulnerable. Apart from being a global health concern, COVID-19 is having major consequences on the world economy. The pandemic has challenged local, national, regional and global capacities to prepare and respond. Health systems globally have employed three common approaches to rapidly scale up health system infrastructure, namely by constructing new treatment facilities, converting public venues and reconfiguring existing medical facilities to provide care for patients with COVID-19. Considerable efforts were being made behind the scenes to develop new strategies to ensure adequate public healthcare infrastructure and workplace capacities. Hospitals have repurposed and reallocated internal space and redeployed resources to manage COVID-19 patients. Countries discharged many patients from hospitals to their homes and postponed non-critical treatment and elective procedures. Almost all hospitals adopted a strategy of hospital approach to COVID-19 with the different primary and secondary goals.\u0000In this article we present a strategy of Mikaelyan University Hospital located in Yerevan, Armenia in managing patients with COVID-19. Preparing for patients’ admission, developing of internal and external hospital communications, reconstruction, redistribution of human resources was carried out in parallel with trainings of health care workers, patients’ education, etc. Mikaelyan University Hospital laboratory was reorganized to implement the new approaches and goals in managing of unprecedented number of patients and to secure quality control. The number of intensive care unit beds has been increased, also all possible efforts have been made to obtain all the required equipment and maintenance. \u0000Overall, the strategy can be considered successful as it was based on the multidisciplinary and multisectoral approach including academic sector, clinicians, leadership, patients, decision makers, nurses, radiologists, psychologists, intensivists, etc.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117312775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of abdominal surgery in combat injuries, our experience","authors":"A. Minasyan, H. Minasyan, D.R. Arazyan, A. Aleksanyan, E.A. Harutunyan","doi":"10.56936/18290825-2022.16.4-74","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.4-74","url":null,"abstract":"The research was carried out in the hospital of the qualified surgical aid stage, where the patients were transferred immediately after receiving first aid from the battlefield. Immediately after admission, all the patients were examined by triage specialists, respiratory and hemodynamic indicators were evaluated according to accepted standards. Most of the injuries were combined polytraumas with severe hemorrhagic shock. All the injured patients were urgently operated. In first group patients who had isolated injuries or combined injuries, but relatively stable hemodynamic parameters, a volume of interventions was performed, which does not require relaparotomy (definitive surgery). Second group patients had combined severe injuries; hemodynamic indicators were unstable. The surgical approach was in accordance with the principle of “damage control”. \u0000The organization of work in the mentioned way made it possible to provide qualified medical care without interruption and on time, depending on the flow intensity of patients and the volume of available resources. For the next stages of medical evacuation, the strategy we chose was understandable, due to which it was possible to avoid additional double surgical aggression in case of first group patients, only by applying the “relaparotomy on demand” principle. In case of second group patients, in some cases, it was possible to postpone the “programmed relaparotomy” and to carry it out in more favorable conditions for the patient. In all cases, when providing qualified surgical care, it should always be taken into account that the intervention performed in this stage should be predictable for the surgeons working at next stage, that is they should understand what principle we have applied, so that they can continue the treatment with the same principle.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115682851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of cerebrovascular activity of new GABA-derived short peptides","authors":"N. Adamyan, Q.M. Shamilyan, A. G. Zhamharyan, H. Topchyan, M. Balasanyan","doi":"10.56936/18290825-2022.16.4-89","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.4-89","url":null,"abstract":"Based on the important role of endogenous substances in the cerebral blood flow regulation, the cerebrovascular activity of new synthesized short peptides of γ-aminobutyric acid (GABA) and pyroglutamate has been investigated, considering the development of new drugs for the correction of cerebral circulation.\u0000Taking into account the proven ability to increase cerebral blood flow of γ-aminobutyric acid and its endogenous metabolites, such as gamma butyrolactone, gamma hydroxybutyric acid, pyrrolidone, pyroglutamic acid, as well as synthetic analogues, such as picamilon, the influence of pyroglutamyl GABA, pyroglutamyl GABA ethyl ester, pyroglutamyl diGABA was observed on local brain blood flow in a state of impaired cerebral circulation. \u0000The model of cerebral chronic hypoperfusion generated by right common carotid artery occlusion was used on rats weighing 180-240 g, under anesthesia with chloral hydrate (400 mg/kg). The investigated peptides were administered at a dose of 20 mg/kg, intraperitoneally. Cerebral blood flow changes were detected by laser Doppler flowmetry.\u0000The conducted experiment revealed differences between the cerebrovascular activities of the studied short peptides. Thus, it was demonstrated that pyroglutamyl GABA exhibits а high ability to increase local cerebral blood flow, stimulating cerebral circulation by 65,2 %, compared with the value of hypoperfusion by right common carotid artery occlusion, after 40 minutes of injection. However, no essential changes in the studied indicator were recorded for pyroglutamyl GABA ethyl ester and pyroglutamyl diGABA.\u0000The obtained data indicate that the prolongation of the short peptide chain leads to a decrease in cerebrovascular activity and opens up new perspectives for the development of pyroglutamyl GABA dipeptide as a promising agent for the correction of cerebral circulation","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115977147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}