Pub Date : 2023-01-01DOI: 10.56936/18290825-2023.17.1-63
F. Karimpour, F.N. Tkhruni, K. Karapetyan, S. Afroughi, A. Peikar, M. Gohargani, N. Tabatabei, B. Ebrahimzadeh Koor, S.O. Salehi
Richal is a traditional fermented dairy beverage that has a long history in the Iranian encyclopedia. This beverage contains whole milk, natural starter, herbs and salt. It can be produced in three different forms, Shiri (from milk), Masti (from yogurt), and Dooghi (from drinking yogurt). The present study was an investigation into the characteristic features of the lactic acid bacteria isolated from Richal Shiri. After preparing the traditional fermented beverage was investigated and several tests such as determining lactic acid and pH were performed on it. Next, lactic acid bacteria and yeasts were isolated from the traditional fermented beverage sample and cultured in different media such as fermented whole or skim milk, at different times temperatures and test cultures. Some strains had anti-bacterial activity against sporogenous microflora S. typhimurium G-38, B. subtilis 17-89, В. Thuringensis 69-6. Eleven Lactic acid bacteria strains were isolated; ten of them were Gram-positive, cocci, and one of them was Gram-positive, Bacillus. Ten strains were catalase-negative and one was catalase positive; the lactic acid bacteria had antibacterial activity by the determination which measuring zone diameters of bacterial growth inhibition. The functions of strains were different but the differences were not significant (p≥0.3). Between the 3 groups, however, B. subtilis 17-89 had the best function. According to the results, Richal Shiri has some lactic acid bacteria strains with anti-bacterial activity and the ability to ferment milk as a starter culture. The isolated fermented milk, according to its properties, may introduce a new functional food product for development in the food industry. These bacteria will be used in future investigations.
{"title":"A study of Iranian traditional dairy beverage (Richal Shiri) and investigation into some properties of its isolated lactic acid bacteria","authors":"F. Karimpour, F.N. Tkhruni, K. Karapetyan, S. Afroughi, A. Peikar, M. Gohargani, N. Tabatabei, B. Ebrahimzadeh Koor, S.O. Salehi","doi":"10.56936/18290825-2023.17.1-63","DOIUrl":"https://doi.org/10.56936/18290825-2023.17.1-63","url":null,"abstract":"Richal is a traditional fermented dairy beverage that has a long history in the Iranian encyclopedia. This beverage contains whole milk, natural starter, herbs and salt. It can be produced in three different forms, Shiri (from milk), Masti (from yogurt), and Dooghi (from drinking yogurt). The present study was an investigation into the characteristic features of the lactic acid bacteria isolated from Richal Shiri. After preparing the traditional fermented beverage was investigated and several tests such as determining lactic acid and pH were performed on it. Next, lactic acid bacteria and yeasts were isolated from the traditional fermented beverage sample and cultured in different media such as fermented whole or skim milk, at different times temperatures and test cultures. Some strains had anti-bacterial activity against sporogenous microflora S. typhimurium G-38, B. subtilis 17-89, В. Thuringensis 69-6. Eleven Lactic acid bacteria strains were isolated; ten of them were Gram-positive, cocci, and one of them was Gram-positive, Bacillus. Ten strains were catalase-negative and one was catalase positive; the lactic acid bacteria had antibacterial activity by the determination which measuring zone diameters of bacterial growth inhibition. The functions of strains were different but the differences were not significant (p≥0.3). Between the 3 groups, however, B. subtilis 17-89 had the best function. According to the results, Richal Shiri has some lactic acid bacteria strains with anti-bacterial activity and the ability to ferment milk as a starter culture. The isolated fermented milk, according to its properties, may introduce a new functional food product for development in the food industry. These bacteria will be used in future investigations.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135784475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.56936/18290825-2023.17.1-84
D. Sai Bhavana, G. Shyamala, B. Sujatha
Present study aimed at determining maternal platelet indices in preterm prelabor rupture of membranes with adverse neonatal consequences. Comparing maternal C-reactive protein efficacy and platelet indices in predicting outcomes. Herein, 82 women with preterm prelabor rupture of membranes and 78 women with spontaneous preterm labor were studied. All women undertook complete blood count tests. The group of preterm prelabor rupture of membranes undertook additional C-reactive protein tests. Neonatal outcome data were compiled post-delivery, and results were compared. C-reactive protein efficacy and platelet indices helped in predicting neonatal outcomes in the group of preterm prelabor rupture of membranes using receiver operating characteristic curve analysis. Women with preterm prelabor rupture of membranes had increased levels of mean platelet volume (8.41 vs. 7.66; p<0.0001), platelet crit (0.223 vs. 0.194; p=0.002), and higher prevalence of early-onset neonatal sepsis (19.5% vs. 2.6%; p<0.001) compared to those with spontaneous preterm labor. In the group of preterm prelabor rupture of membranes, mean platelet volume, platelet crit, and C-reactive protein were significantly associated with respiratory distress syndrome and early-onset neonatal sepsis. The cut-off values mean platelet volume ≥ 8.55fL, platelet crit of ≥0.255%, and C-reactive protein of 5mg/L predicted respiratory distress syndrome with an area under the curve of 0.84, 0.92 and 0.72, the sensitivity of 83%, 91%, and 62%, and specificity of 78.1%, 92.2%, and 68.2%, respectively. The cut-off values of mean platelet volume ≥ 9.05 fL, platelet crit of ≥0.283%, and C-reactive protein of 6mg/L predicted early-onset neonatal sepsis with an area under the curve of 0.86, 0.90 and 0.65, sensitivity of 87.5%, 93%, and 56%, and specificity of 75%, 85%, and 66%, respectively. Maternal mean platelet volume and platelet crit are useful predictors of neonatal respiratory distress syndrome and early-onset neonatal sepsis in mothers with preterm prelabor rupture of membranes and werebetter predictors of neonatal outcomes than C-reactive protein.
本研究旨在测定早产胎膜破裂与新生儿不良后果的母体血小板指数。比较母体c反应蛋白疗效和血小板指标对预后的预测作用。本文对82例早产胎膜破裂妇女和78例自发性早产妇女进行了研究。所有妇女都进行了全血细胞计数检查。早产胎膜破裂组进行额外的c反应蛋白检测。分娩后收集新生儿结局数据，并对结果进行比较。采用受体工作特征曲线分析，c反应蛋白疗效和血小板指标有助于预测早产胎膜破裂组新生儿结局。早产胎膜破裂的妇女平均血小板体积增加(8.41 vs. 7.66;P<0.0001)，血小板临界值(0.223 vs. 0.194;P =0.002)，早发性新生儿败血症的患病率更高(19.5% vs. 2.6%;P<0.001)与自然早产相比。在早产胎膜破裂组中，平均血小板体积、血小板临界率、c反应蛋白与呼吸窘迫综合征和早发型新生儿败血症显著相关。截断值平均为血小板体积≥8.55fL、血小板临界值≥0.255%、c反应蛋白5mg/L预测呼吸窘迫综合征的曲线下面积分别为0.84、0.92和0.72，敏感性分别为83%、91%和62%，特异性分别为78.1%、92.2%和68.2%。平均血小板体积≥9.05 fL、血小板临界值≥0.283%、c反应蛋白6mg/L的临界值预测早发病新生儿脓毒症的曲线下面积分别为0.86、0.90和0.65，敏感性分别为87.5%、93%和56%，特异性分别为75%、85%和66%。产妇平均血小板体积和血小板危重是新生儿呼吸窘迫综合征和早发性新生儿脓毒症的有效预测因子，并且比c反应蛋白更能预测新生儿结局。
{"title":"Accounts of adverse neonatal effects in preterm prelabor rupture of membranes: anticipating maternal platelet indices and C-reactive protein as effective biomarkers","authors":"D. Sai Bhavana, G. Shyamala, B. Sujatha","doi":"10.56936/18290825-2023.17.1-84","DOIUrl":"https://doi.org/10.56936/18290825-2023.17.1-84","url":null,"abstract":"Present study aimed at determining maternal platelet indices in preterm prelabor rupture of membranes with adverse neonatal consequences. Comparing maternal C-reactive protein efficacy and platelet indices in predicting outcomes. Herein, 82 women with preterm prelabor rupture of membranes and 78 women with spontaneous preterm labor were studied. All women undertook complete blood count tests. The group of preterm prelabor rupture of membranes undertook additional C-reactive protein tests. Neonatal outcome data were compiled post-delivery, and results were compared. C-reactive protein efficacy and platelet indices helped in predicting neonatal outcomes in the group of preterm prelabor rupture of membranes using receiver operating characteristic curve analysis. Women with preterm prelabor rupture of membranes had increased levels of mean platelet volume (8.41 vs. 7.66; p<0.0001), platelet crit (0.223 vs. 0.194; p=0.002), and higher prevalence of early-onset neonatal sepsis (19.5% vs. 2.6%; p<0.001) compared to those with spontaneous preterm labor. In the group of preterm prelabor rupture of membranes, mean platelet volume, platelet crit, and C-reactive protein were significantly associated with respiratory distress syndrome and early-onset neonatal sepsis. The cut-off values mean platelet volume ≥ 8.55fL, platelet crit of ≥0.255%, and C-reactive protein of 5mg/L predicted respiratory distress syndrome with an area under the curve of 0.84, 0.92 and 0.72, the sensitivity of 83%, 91%, and 62%, and specificity of 78.1%, 92.2%, and 68.2%, respectively. The cut-off values of mean platelet volume ≥ 9.05 fL, platelet crit of ≥0.283%, and C-reactive protein of 6mg/L predicted early-onset neonatal sepsis with an area under the curve of 0.86, 0.90 and 0.65, sensitivity of 87.5%, 93%, and 56%, and specificity of 75%, 85%, and 66%, respectively. Maternal mean platelet volume and platelet crit are useful predictors of neonatal respiratory distress syndrome and early-onset neonatal sepsis in mothers with preterm prelabor rupture of membranes and werebetter predictors of neonatal outcomes than C-reactive protein.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"271 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135829506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.56936/18290825-2023.17.1-70
Ahmed Wegdan, Aladin Saad, Samy Ahmed, Mohammed H. Karrar Alsharif, Amani Elfaki
Cingulate gyrus is a part of the limbic lobe. Anatomically and functionally, the cingulate gyrus is subdivided into four areas: the anterior cingulate cortex, midcingulate cortex, posterior cingulate gyrus, and the retrosplenial part. The variety of autonomic functions, such as regulating heart rate and blood pressure and having a major role in cognitive function, also has a function in emotional cognition. The present study aims to measure cortical thickness and cortical volume in apparently healthy young adult Sudanese. In this cross-sectional study, randomly selected individuals (30 males, 30 females) among the Sudanese population, aged between 20-40 years, and who had normal brain magnetic resonance images were included in the study. All study participants underwent magnetic resonance imaging, and measurements of the cingulate gyrus were assessed using BrainSuite software. Analysis was conducted using Statistical Package for the Social Sciences, version 28, and p-values less than 0.05 were considered significant. For the right cingulate gyrus, the mean cortical thickness and cortical volume were 4.0 mm and 20.9 cm3, respectively. The mean cortical thickness and volume in the left cingulate gyrus were 4.0 mm and 22.3 cm3, respectively. The cortical volume of the left cingulate gyrus was statistically significantly larger than the right (p=0.04). The right and left cingulate gyrus cortical volumes of males were significantly larger than that of females (p=0.001), while the cortical thickness showed an insignificant difference (p=0.3). The cortical volume of the cingulate gyrus was not statistically related to age or body mass index. The left cingulate gyrus’s total volume is larger than that of the right cingulate gyrus, and there is no significant difference in cortical thickness. Age and body mass index do not affect cortical volume and thickness.
扣带回是大脑边缘叶的一部分。在解剖学和功能上，扣带回被细分为四个区域:前扣带皮层、中扣带皮层、后扣带回和脾后部分。各种各样的自主神经功能，如调节心率和血压，在认知功能中起着重要作用，也在情绪认知中起作用。本研究旨在测量表面健康的苏丹年轻成人的皮质厚度和皮质体积。在这项横断面研究中，在苏丹人口中随机选择个体(30名男性，30名女性)，年龄在20-40岁之间，脑磁共振成像正常。所有的研究参与者都接受了磁共振成像，并使用BrainSuite软件评估了扣带回的测量值。使用Statistical Package for the Social Sciences, version 28进行分析，p值小于0.05被认为是显著的。右侧扣带回平均皮质厚度4.0 mm，皮质体积20.9 cm3。左扣带回平均皮质厚度4.0 mm，体积22.3 cm3。左侧扣带回皮质体积明显大于右侧(p=0.04)。男性左右扣带回皮质体积显著大于女性(p=0.001)，而皮质厚度差异不显著(p=0.3)。扣带回皮质体积与年龄或体重指数无统计学相关性。左扣带回总体积大于右扣带回，皮质厚度差异无统计学意义。年龄和体重指数不影响皮质体积和厚度。
{"title":"Cortical thickness and cortical volume measurements of the cingulate gyrus in Sudanese young adult using BrainSuite","authors":"Ahmed Wegdan, Aladin Saad, Samy Ahmed, Mohammed H. Karrar Alsharif, Amani Elfaki","doi":"10.56936/18290825-2023.17.1-70","DOIUrl":"https://doi.org/10.56936/18290825-2023.17.1-70","url":null,"abstract":"Cingulate gyrus is a part of the limbic lobe. Anatomically and functionally, the cingulate gyrus is subdivided into four areas: the anterior cingulate cortex, midcingulate cortex, posterior cingulate gyrus, and the retrosplenial part. The variety of autonomic functions, such as regulating heart rate and blood pressure and having a major role in cognitive function, also has a function in emotional cognition. The present study aims to measure cortical thickness and cortical volume in apparently healthy young adult Sudanese. In this cross-sectional study, randomly selected individuals (30 males, 30 females) among the Sudanese population, aged between 20-40 years, and who had normal brain magnetic resonance images were included in the study. All study participants underwent magnetic resonance imaging, and measurements of the cingulate gyrus were assessed using BrainSuite software. Analysis was conducted using Statistical Package for the Social Sciences, version 28, and p-values less than 0.05 were considered significant. For the right cingulate gyrus, the mean cortical thickness and cortical volume were 4.0 mm and 20.9 cm3, respectively. The mean cortical thickness and volume in the left cingulate gyrus were 4.0 mm and 22.3 cm3, respectively. The cortical volume of the left cingulate gyrus was statistically significantly larger than the right (p=0.04). The right and left cingulate gyrus cortical volumes of males were significantly larger than that of females (p=0.001), while the cortical thickness showed an insignificant difference (p=0.3). The cortical volume of the cingulate gyrus was not statistically related to age or body mass index. The left cingulate gyrus’s total volume is larger than that of the right cingulate gyrus, and there is no significant difference in cortical thickness. Age and body mass index do not affect cortical volume and thickness.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135829505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diabetic neuropathy is the most common and bothersome diabetes mellitus complication, leading to considerable morbidity and mortality. The results of these studies and the importance of early detection and prevention of polyneuropathy in diabetic patients motivated the authors to carry out the present study. In this cross-sectional study all consecutive patients with type 2 diabetes mellitus were referred to the Endocrinology Clinic at Golestan Hospital in Ahvaz, Iran. The Nihon Kochden gadget was utilized on all patients, who were all examined by an individual. Average sensory amplitude was defined as greater than 6 V for the sural nerve and greater than 15 V for the radial nerve. In the present investigation, a sural/radial nerve amplitude ratio greater than or equal to 21 percent was considered normal. In total, 80 subjects were included in the analysis, there is a non-significant direct correlation between the sural nerve and sural/radial nerve amplitude ratio, to diagnose patients with and without neuropathy (p=0.625). Moreover, there is a non-significant direct correlation between the sural nerve and sural/radial nerve amplitude ratio with the body mass index of patients with diabetes, and this correlation is negligible (p>0.05). The findings demonstrated that sural/radial nerve amplitude ratio was a promising method for detecting neuropathy in patients with type 2 diabetes. Also, sural nerve and sural/radial nerve amplitude ratio had a significant inversion relationship with age and duration of diabetes for detecting diabetic neuropathy in type 2 diabetes patients
{"title":"Comparison of Sural Nerve Amplitude and Sural/Radial Amplitude Ratio in Electrodiagnosis of patients with neuropathy in Type 2 diabetes","authors":"Gholamreza Shamsaei, Mehrnoosh Zakerkish, Davood Kashipazha, Maryam Moradi, Hossein Zakizadeh","doi":"10.56936/18290825-2023.17.1-77","DOIUrl":"https://doi.org/10.56936/18290825-2023.17.1-77","url":null,"abstract":"Diabetic neuropathy is the most common and bothersome diabetes mellitus complication, leading to considerable morbidity and mortality. The results of these studies and the importance of early detection and prevention of polyneuropathy in diabetic patients motivated the authors to carry out the present study. In this cross-sectional study all consecutive patients with type 2 diabetes mellitus were referred to the Endocrinology Clinic at Golestan Hospital in Ahvaz, Iran. The Nihon Kochden gadget was utilized on all patients, who were all examined by an individual. Average sensory amplitude was defined as greater than 6 V for the sural nerve and greater than 15 V for the radial nerve. In the present investigation, a sural/radial nerve amplitude ratio greater than or equal to 21 percent was considered normal. In total, 80 subjects were included in the analysis, there is a non-significant direct correlation between the sural nerve and sural/radial nerve amplitude ratio, to diagnose patients with and without neuropathy (p=0.625). Moreover, there is a non-significant direct correlation between the sural nerve and sural/radial nerve amplitude ratio with the body mass index of patients with diabetes, and this correlation is negligible (p>0.05). The findings demonstrated that sural/radial nerve amplitude ratio was a promising method for detecting neuropathy in patients with type 2 diabetes. Also, sural nerve and sural/radial nerve amplitude ratio had a significant inversion relationship with age and duration of diabetes for detecting diabetic neuropathy in type 2 diabetes patients","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135784474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.56936/18290825-2023.17.3-11
Nurdiana N., Winarsih S., Tri Endharti A., Handayani S.
Abstract Toll-like receptor 4 is a marker that indicates whether or not tissues have immunological or pro-inflammatory responses. Candida albicans has the potential to aggravate the tissue that makes up the epithelium. After candidiasis, the antifungal properties of holothurin and caspofungin have the ability to block toll-like receptor 4. A total of 48 white rats Rattus norvegius Wistar were divided into four positive control groups (P1) and given topical C. albicans after being grown in yeast extract peptone dextrose in the vagina of white rats Rattus norvegius Wistar. P2 and P3 groups were given 3500 g holothurin and 140 g caspofugin topically in the vagina of animal models at 12-, 24-, and 48-hour intervals. Immunofluorescence was used to analyse the study results both quantitatively and qualitatively by attaching the imaging. After that, the data was processed using the SPSS statistical software version 23. Toll-like receptor 4 expression decreased significantly in the treatment group compared to the positive control group (p0.05). This demonstrates that holothurin (P1) and caspofungin (P2) treatments reduced toll-like receptor 4 expression in C. albicans at 0.25 and 6.375 at 12 hours, 0.62 and 3. at 24 hours, and 1.68 and 4.18 at 48 hours. The mean difference in toll-like receptor 4 expression in the positive control group, on the other hand, did not differ statistically when compared to the negative (healthy) control group. This demonstrates that the treatment group’s holothurin and caspofungin have the potential to reduce toll-like receptor 4 expression. Holothurin has a potential effect compared to caspofungin on experimental animals with candidiasis experiencing significant changes in suppressing the number of toll-like receptor 4 in vaginal epithelial tissue of Rattus norvegicus Wistar
{"title":"Holothurin And Caspofungin-Induced Alterations In Ttoll-Like Receptor 4expression In The Vagina Of Rattus Norvegicus Wistar With Candidiasis","authors":"Nurdiana N., Winarsih S., Tri Endharti A., Handayani S.","doi":"10.56936/18290825-2023.17.3-11","DOIUrl":"https://doi.org/10.56936/18290825-2023.17.3-11","url":null,"abstract":"Abstract Toll-like receptor 4 is a marker that indicates whether or not tissues have immunological or pro-inflammatory responses. Candida albicans has the potential to aggravate the tissue that makes up the epithelium. After candidiasis, the antifungal properties of holothurin and caspofungin have the ability to block toll-like receptor 4. A total of 48 white rats Rattus norvegius Wistar were divided into four positive control groups (P1) and given topical C. albicans after being grown in yeast extract peptone dextrose in the vagina of white rats Rattus norvegius Wistar. P2 and P3 groups were given 3500 g holothurin and 140 g caspofugin topically in the vagina of animal models at 12-, 24-, and 48-hour intervals. Immunofluorescence was used to analyse the study results both quantitatively and qualitatively by attaching the imaging. After that, the data was processed using the SPSS statistical software version 23. Toll-like receptor 4 expression decreased significantly in the treatment group compared to the positive control group (p0.05). This demonstrates that holothurin (P1) and caspofungin (P2) treatments reduced toll-like receptor 4 expression in C. albicans at 0.25 and 6.375 at 12 hours, 0.62 and 3. at 24 hours, and 1.68 and 4.18 at 48 hours. The mean difference in toll-like receptor 4 expression in the positive control group, on the other hand, did not differ statistically when compared to the negative (healthy) control group. This demonstrates that the treatment group’s holothurin and caspofungin have the potential to reduce toll-like receptor 4 expression. Holothurin has a potential effect compared to caspofungin on experimental animals with candidiasis experiencing significant changes in suppressing the number of toll-like receptor 4 in vaginal epithelial tissue of Rattus norvegicus Wistar","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135263511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.56936/18290825-2022.16.2-100
R. Markosyan, H.N. Babayan
Graves’ disease is an autoimmune disease that may consist of hyperthyroidism, goiter, orbitopathy, and occasionally a dermopathy referred to as pretibial or localized myxedema. Graves’ disease is caused by autoantibodies that bind to the thyrotropin receptor, stimulating growth of the thyroid and overproduction of thyroid hormone. Clinical manifestations of Graves’ disease include diffuse goiter and symptoms and signs resulting from hyperthyroidism. Thyroid hormones excess affects several different body systems, and for this reason, signs and symptoms associated with Graves’ disease can vary strongly, and significantly influence the general well-being. Common symptoms are: tremor, heat sensitivity and warm, weight loss even if with normal eating habits, anxiety and irritability, enlargement of the thyroid gland, alterations in menstrual cycles, erectile dysfunction or decreased libido, fatigue, frequent bowel movements, palpitations, and others. Graves’ orbitopathy is present in about 30-50% of patients with Graves disease. Graves’ orbitopathy is an autoimmune disease of the retroocular tissues occurring in patients with Graves’ disease.We present the clinical case report with progressive ophthalmopathy after a total thyroidectomy. In our case after surgery his ophthalmopathy did not regress and, in fact, was progressive. In the vast majority of cases of Grave’s ophthalmopathy, the periorbital edema regresses significantly after a total thyroidectomy. This patient’s ophthalmopathy did not regress after surgery even the ophtalmopathy progressed. Only after initiation of pulsatile therapy of 500 mg of methylprednisolone weekly did the ophthalmopathy regress noticeably.
{"title":"Graves diseases with severe progressive ophthalmopathy after thyroidectomy. Case report.","authors":"R. Markosyan, H.N. Babayan","doi":"10.56936/18290825-2022.16.2-100","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.2-100","url":null,"abstract":"Graves’ disease is an autoimmune disease that may consist of hyperthyroidism, goiter, orbitopathy, and occasionally a dermopathy referred to as pretibial or localized myxedema. Graves’ disease is caused by autoantibodies that bind to the thyrotropin receptor, stimulating growth of the thyroid and overproduction of thyroid hormone. Clinical manifestations of Graves’ disease include diffuse goiter and symptoms and signs resulting from hyperthyroidism.\u0000Thyroid hormones excess affects several different body systems, and for this reason, signs and symptoms associated with Graves’ disease can vary strongly, and significantly influence the general well-being. Common symptoms are: tremor, heat sensitivity and warm, weight loss even if with normal eating habits, anxiety and irritability, enlargement of the thyroid gland, alterations in menstrual cycles, erectile dysfunction or decreased libido, fatigue, frequent bowel movements, palpitations, and others. Graves’ orbitopathy is present in about 30-50% of patients with Graves disease. Graves’ orbitopathy is an autoimmune disease of the retroocular tissues occurring in patients with Graves’ disease.We present the clinical case report with progressive ophthalmopathy after a total thyroidectomy. In our case after surgery his ophthalmopathy did not regress and, in fact, was progressive. In the vast majority of cases of Grave’s ophthalmopathy, the periorbital edema regresses significantly after a total thyroidectomy. This patient’s ophthalmopathy did not regress after surgery even the ophtalmopathy progressed. Only after initiation of pulsatile therapy of 500 mg of methylprednisolone weekly did the ophthalmopathy regress noticeably.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128651549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.56936/18290825-2022.16.2-76
S. Ebrahimi, H. Motamed, H. Kalantar, A. Kalantari, F. Rahim
Context: Annually thousands of people lose their lives due to air pollution. Today, air pollution in most countries, especially developing countries, is a public health problem and millions of dollars spent to treat patients who admitted to the emergency department due to exposure to air pollutants. Study on hospital admissions is a method for the impact survey of ambient air pollution on a human. Evidence Acquisition: In this study reviewed the effects of air pollutants (No2, SO2, PM2.5, PM10, CO, PAH and VOCs) on human health, with a focus on hospital admission after short-term exposure. In the articles literature that reviewed Short-term exposure to ambient air pollutants including No2, SO2, PM2.5, PM10 and CO led to hospital admission (except for PAH and VOCs). We systematically searched international datasets to identify relevant studies, including PubMed, Scopus, Cochrane library, CINAHL, ISI Web of Science, Science Direct from inception, PROSPERO and EMBASE using medical purposed subject headings (Mesh) terms. Result: The most common cause of hospital admission after short-term exposure to air pollution was cardiovascular and respiratory diseases. The health effects of air pollution on studied groups in dry and warm weather were higher than in wet and cold weather. In studies with more pollutants, the share of each pollutant in hospital admission was clearer. Conclusion: The costs of treatment were far higher than the cost of prevention. The effectiveness of preventive methods was more than therapeutic methods. The history of exposure to ambient air pollutants and their impact on hospital admission rate due to short-term exposure to air pollutants require separate studies in this field. More accurate identification of the toxicological mechanisms seemed to be necessary after the short-term exposure to deal with acute poisoning due to air pollution.
每年有成千上万的人因空气污染而丧生。今天，在大多数国家，特别是发展中国家，空气污染是一个公共卫生问题，数百万美元用于治疗因接触空气污染物而入院的病人。住院研究是环境空气污染对人体影响调查的一种方法。证据获取:本研究回顾了空气污染物(No2、SO2、PM2.5、PM10、CO、PAH和VOCs)对人体健康的影响，重点关注了短期暴露后的住院情况。在文章中，文献回顾了短期暴露于环境空气污染物包括No2, SO2, PM2.5, PM10和CO导致住院(PAH和VOCs除外)。我们系统地检索了国际数据集以确定相关研究，包括PubMed、Scopus、Cochrane图书馆、CINAHL、ISI Web of Science、Science Direct from inception、PROSPERO和EMBASE，使用医学目的主题标题(Mesh)术语。结果:短期空气污染暴露后最常见的住院原因是心血管和呼吸系统疾病。在干燥和温暖的天气中，空气污染对研究人群的健康影响高于潮湿和寒冷天气。在污染物较多的研究中，每种污染物在住院患者中所占的比例更清晰。结论:治疗费用远高于预防费用。预防方法的效果大于治疗方法。暴露于环境空气污染物的历史及其对因短期暴露于空气污染物而住院率的影响需要在这一领域进行单独研究。短期接触后更准确地识别毒理学机制似乎是处理空气污染急性中毒的必要条件。
{"title":"Hospital Admissions Due to Short-term Exposure to Air Pollution: A scoping review","authors":"S. Ebrahimi, H. Motamed, H. Kalantar, A. Kalantari, F. Rahim","doi":"10.56936/18290825-2022.16.2-76","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.2-76","url":null,"abstract":"Context: Annually thousands of people lose their lives due to air pollution. Today, air pollution in most countries, especially developing countries, is a public health problem and millions of dollars spent to treat patients who admitted to the emergency department due to exposure to air pollutants. Study on hospital admissions is a method for the impact survey of ambient air pollution on a human. Evidence Acquisition: In this study reviewed the effects of air pollutants (No2, SO2, PM2.5, PM10, CO, PAH and VOCs) on human health, with a focus on hospital admission after short-term exposure. In the articles literature that reviewed Short-term exposure to ambient air pollutants including No2, SO2, PM2.5, PM10 and CO led to hospital admission (except for PAH and VOCs). We systematically searched international datasets to identify relevant studies, including PubMed, Scopus, Cochrane library, CINAHL, ISI Web of Science, Science Direct from inception, PROSPERO and EMBASE using medical purposed subject headings (Mesh) terms. Result: The most common cause of hospital admission after short-term exposure to air pollution was cardiovascular and respiratory diseases. The health effects of air pollution on studied groups in dry and warm weather were higher than in wet and cold weather. In studies with more pollutants, the share of each pollutant in hospital admission was clearer. Conclusion: The costs of treatment were far higher than the cost of prevention. The effectiveness of preventive methods was more than therapeutic methods. The history of exposure to ambient air pollutants and their impact on hospital admission rate due to short-term exposure to air pollutants require separate studies in this field. More accurate identification of the toxicological mechanisms seemed to be necessary after the short-term exposure to deal with acute poisoning due to air pollution.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126350573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.56936/18290825-2022.16.3-78
E. V. Maksimova, I. L. Kliaritskaia, E. I. Grigorenko, Y. Moshko
Introduction: Drug-induced liver injury is one of the most serious problems in hepatology. In most cases the abolition of the “causative” drug is a sufficient condition for the reverse development of pathological changes. However, in the case of chemotherapy for cancer patients, the abolition of hepatotoxic drug is impossible without creating an immediate or delayed threat to the patient’s life. Objective: To develop optimal schemes for the prevention and treatment of drug-induced liver injury by studying of its characteristics of with various chemotherapy regimens in patients with breast cancer and ovarian cancer. Material and methods: The screening group included 291 patients who underwent chemotherapy courses for breast cancer and ovarian cancer. The diagnosis and type of drug-induced liver injury was based on laboratory data (alanine aminotransferase and/or alkaline phosphatase increased above 2 norms) and the exclusion of other etiologies of liver diseases. Chemotherapy hepatotoxicity was assessed using the Shaposhnikov scale. The degree of hepatic encephalopathy was determined using a critical flicker frequency test. Depending on chemotherapy mode, groups of the patients were divided into subgroups: cyclophosphamide + Methotrexate+ Fluorouracil, Doxorubici + Cyclophosphamide, Epirubicin + Cyclophosphamide + 5-fluorouracil, Paclitaxel + Cisplatin, Carboplatin + Cyclophosphamide. According to the type of drug-induced liver injury, patients with cholestatic type received preparations, with cytolytic type – S-adenosylmethionine for 8 weeks. Results and its discussion: It was found that the most common side effect of chemotherapy is leukopenia, anemia and increase in level of alanine aminotransferase and alkaline phosphatase. The use of ursodeoxycholic acid and S-adenosylmethionine as an accompanying therapy significantly reduces the level of alanine aminotransferase and alkaline phosphatase degree of hepatotoxicity and hepatic encephalopathy, clinical improves the quality of life of patients and contributes to a more rapid elimination of symptoms of astheno-vegetative, dyspeptic and pain syndromes. Conclusion: It has been proven that the use of a differentiated approach to the choice of a hepatoprotector: S-adenosylmethionine in hepatocellular type, ursodeoxycholic acid - in cholestatic type of drug-induced liver injury for 8 weeks in patients with oncological profile allowed to carry out the planned therapy without deviations from the protocol.
药物性肝损伤是肝病学中最严重的问题之一。在大多数情况下，“致病”药物的消除是病理变化逆转发展的充分条件。然而，就癌症患者的化疗而言，在不立即或延迟威胁患者生命的情况下，取消肝毒性药物是不可能的。目的:通过研究乳腺癌、卵巢癌患者药物性肝损伤与不同化疗方案的特点，探讨药物性肝损伤的最佳防治方案。材料和方法:筛选组包括291例接受乳腺癌和卵巢癌化疗的患者。药物性肝损伤的诊断和类型基于实验室数据(丙氨酸转氨酶和/或碱性磷酸酶升高高于2个标准)，并排除其他肝脏疾病病因。采用沙波什尼科夫评分法评估化疗肝毒性。肝性脑病的程度是用临界闪烁频率试验确定的。根据化疗方式将患者分组分为:环磷酰胺+甲氨蝶呤+氟尿嘧啶、阿霉素+环磷酰胺、表柔比星+环磷酰胺+ 5-氟尿嘧啶、紫杉醇+顺铂、卡铂+环磷酰胺等亚组。根据药物性肝损伤类型，胆汁淤积型患者给予溶细胞型- s -腺苷蛋氨酸制剂，疗程8周。结果及讨论:化疗最常见的副作用是白细胞减少、贫血、谷丙转氨酶和碱性磷酸酶水平升高。使用熊去氧胆酸和s -腺苷蛋氨酸作为辅助治疗，可显著降低肝毒性和肝性脑病的丙氨酸转氨酶和碱性磷酸酶水平，提高临床患者的生活质量，有助于更迅速地消除植物无力、消化不良和疼痛综合征的症状。结论:已经证明，使用一种不同的方法来选择肝保护剂:肝细胞型s -腺苷蛋氨酸，胆汁淤积型熊去氧胆酸-在8周的肿瘤特征的药物性肝损伤患者中，允许进行计划治疗而不偏离方案。
{"title":"Prevention and treatment of drug-induced liver injury in patients with breast cancer and ovarian cancer","authors":"E. V. Maksimova, I. L. Kliaritskaia, E. I. Grigorenko, Y. Moshko","doi":"10.56936/18290825-2022.16.3-78","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.3-78","url":null,"abstract":"Introduction: Drug-induced liver injury is one of the most serious problems in hepatology. In most cases the abolition of the “causative” drug is a sufficient condition for the reverse development of pathological changes. However, in the case of chemotherapy for cancer patients, the abolition of hepatotoxic drug is impossible without creating an immediate or delayed threat to the patient’s life. \u0000Objective: To develop optimal schemes for the prevention and treatment of drug-induced liver injury by studying of its characteristics of with various chemotherapy regimens in patients with breast cancer and ovarian cancer.\u0000Material and methods: The screening group included 291 patients who underwent chemotherapy courses for breast cancer and ovarian cancer. The diagnosis and type of drug-induced liver injury was based on laboratory data (alanine aminotransferase and/or alkaline phosphatase increased above 2 norms) and the exclusion of other etiologies of liver diseases. Chemotherapy hepatotoxicity was assessed using the Shaposhnikov scale. The degree of hepatic encephalopathy was determined using a critical flicker frequency test. Depending on chemotherapy mode, groups of the patients were divided into subgroups: cyclophosphamide + Methotrexate+ Fluorouracil, Doxorubici + Cyclophosphamide, Epirubicin + Cyclophosphamide + 5-fluorouracil, Paclitaxel + Cisplatin, Carboplatin + Cyclophosphamide. According to the type of drug-induced liver injury, patients with cholestatic type received preparations, with cytolytic type – S-adenosylmethionine for 8 weeks.\u0000Results and its discussion: It was found that the most common side effect of chemotherapy is leukopenia, anemia and increase in level of alanine aminotransferase and alkaline phosphatase. The use of ursodeoxycholic acid and S-adenosylmethionine as an accompanying therapy significantly reduces the level of alanine aminotransferase and alkaline phosphatase degree of hepatotoxicity and hepatic encephalopathy, clinical improves the quality of life of patients and contributes to a more rapid elimination of symptoms of astheno-vegetative, dyspeptic and pain syndromes.\u0000Conclusion: It has been proven that the use of a differentiated approach to the choice of a hepatoprotector: S-adenosylmethionine in hepatocellular type, ursodeoxycholic acid - in cholestatic type of drug-induced liver injury for 8 weeks in patients with oncological profile allowed to carry out the planned therapy without deviations from the protocol.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"146 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132669291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.56936/18290825-2022.16.2-104
M. Кhanchi, A. Matkerimov, A. Tergeussizov, T. Demeuov, M. Zhakubayev, M. Khanchi, A. Baubekov, N. Yerkinbayev, A. Saduakas, R. Makkamov
Visceral artery aneurysms are detected when complications occur or accidentally during examination for other diseases gastrointestinal tract, aimed at determining the functional significance. Over the past 10 years, we have observed 31 patients with abdominal visceral artery aneurysms, 10 patients had renal aneurysms, 15 had splenic arteries, hepatic artery and pancreatoduodenal artery aneurysms – in one case. The combination of aneurysms – in 2 cases: in one case – the renal artery with the splenic artery, in the other – the renal artery and the abdominal trunk. The patients ranged in age from 24 to 78 years, the average age is 43±6.5. Previously, infection was considered the most common cause of splenic artery aneurysms in 10 cases, with most patients complaining of fever, abdominal pain and a pulsating mass in the abdomen. And two patients with splenic artery aneurysm noted abdominal trauma. 3 had atherosclerotic changes. The causes of renal artery aneurysms are atherosclerosis in 6 cases, fibromuscular dysplasia in 2 cases, and Nonspecific aortoarteritis in 2 cases. Also, atherosclerotic etiology is present in aneurysms of the external iliac arteries aneurysms. Reconstructions on hepatobiliary aneurysms were performed in 6 (20%) cases, in 5 cases - resection with end-to-end anastomosis and in 2 cases - resection of splenic artery aneurysm, resection of splenic artery aneurysms with autovenous patch, clipping of splenic artery aneurysms – in 2 cases (6.5%), endovascular techniques were applied in 18 cases (58%). In 2 cases, nephroectomy was performed due to the spread of the aneurysm into the kidney gate and the lack of conditions for reconstruction. In the immediate and long-term (after 6 months and 3 years) postoperative period, the preservation of organ function in reconstructive and ligating methods of surgical treatment is the same. Signs of ischemia and impairment in the immediate postoperative period were not observed with reconstructive and ligating methods of surgical treatment. The choice of treatment method depends on the severity of the patient’s condition, clinical manifestations, as well as the localization of the aneurysm and its morphology. Preference is given to endovascular techniques, which are not traumatic enough and provide a good long-term result. However, in each case, the patient’s management tactics are individual, the choice of the optimal method of treatment of visceral artery aneurysms is based on data from the entire spectrum of possible diagnostic manipulations.
{"title":"Surgical treatment of visceral and renal abdominal artery aneurysms of various etiology","authors":"M. Кhanchi, A. Matkerimov, A. Tergeussizov, T. Demeuov, M. Zhakubayev, M. Khanchi, A. Baubekov, N. Yerkinbayev, A. Saduakas, R. Makkamov","doi":"10.56936/18290825-2022.16.2-104","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.2-104","url":null,"abstract":"Visceral artery aneurysms are detected when complications occur or accidentally during examination for other diseases gastrointestinal tract, aimed at determining the functional significance.\u0000Over the past 10 years, we have observed 31 patients with abdominal visceral artery aneurysms, 10 patients had renal aneurysms, 15 had splenic arteries, hepatic artery and pancreatoduodenal artery aneurysms – in one case. The combination of aneurysms – in 2 cases: in one case – the renal artery with the splenic artery, in the other – the renal artery and the abdominal trunk. The patients ranged in age from 24 to 78 years, the average age is 43±6.5.\u0000Previously, infection was considered the most common cause of splenic artery aneurysms in 10 cases, with most patients complaining of fever, abdominal pain and a pulsating mass in the abdomen. And two patients with splenic artery aneurysm noted abdominal trauma. 3 had atherosclerotic changes. The causes of renal artery aneurysms are atherosclerosis in 6 cases, fibromuscular dysplasia in 2 cases, and Nonspecific aortoarteritis in 2 cases. Also, atherosclerotic etiology is present in aneurysms of the external iliac arteries aneurysms.\u0000Reconstructions on hepatobiliary aneurysms were performed in 6 (20%) cases, in 5 cases - resection with end-to-end anastomosis and in 2 cases - resection of splenic artery aneurysm, resection of splenic artery aneurysms with autovenous patch, clipping of splenic artery aneurysms – in 2 cases (6.5%), endovascular techniques were applied in 18 cases (58%).\u0000In 2 cases, nephroectomy was performed due to the spread of the aneurysm into the kidney gate and the lack of conditions for reconstruction.\u0000In the immediate and long-term (after 6 months and 3 years) postoperative period, the preservation of organ function in reconstructive and ligating methods of surgical treatment is the same.\u0000Signs of ischemia and impairment in the immediate postoperative period were not observed with reconstructive and ligating methods of surgical treatment.\u0000The choice of treatment method depends on the severity of the patient’s condition, clinical manifestations, as well as the localization of the aneurysm and its morphology. Preference is given to endovascular techniques, which are not traumatic enough and provide a good long-term result. However, in each case, the patient’s management tactics are individual, the choice of the optimal method of treatment of visceral artery aneurysms is based on data from the entire spectrum of possible diagnostic manipulations.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"190 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124214975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.56936/18290825-2022.16.3-86
K. Tokhunts, A. Khudaverdyan, N.B. Abgaryan, N. Nahapetyan, V. Manvelyan
Objectives: Intrauterine hormone-releasing systems are now widely applied to treat metrorrhagia (polymenorrhea), endometrial hyperplasia and adenomyosis. In previous works we found that risk factors for expulsion of intrauterine device, besides the deformation of the uterine cavity, was the expansion of uterine cavity area > 9 cm2, associated with increased distance between tubal angles >4.5 cm and after the insertion of Levonorgestrel-releasing Intrauterine System (Mirena), among the patients with indicated parameters of uterine cavity, the expulsion reached 90%. Another widely used medicine for treatment of metrorrhagia (polymenorrhea), endometrial hyperplasia and adenomyosis is dienogest (Vizanna). The objective of this study is to explore the influence of combined administration of dienogest and Levonorgestrel- releasing Intrauterine System with the purpose of prevention of complications and side effects of the Intrauterine System. Study design: This prospective study includes 32 patients with previous Levonorgestrel-releasing Intrauterine System expultions whom Dienogest 2mg daily has been administered within 6 months. Results: Ultrasound transformation of a myometrium and uterine cavity in 6 months after Vizanna administration was manifested by minimization of uterine cavity and reduction of distance between tubal angles. Mirena was inserted to these patients again. Within 12 months of monitoring any case of expulsion was not observed. Conclusions: According to the data received, the combined consistent and simultaneous administration of Dienogest and Mirena reduces the possibility of Intrauterine System expulsion and decreases side effects of the Intrauterine System. Implication statement: Combined consistent and simultaneous administration of Dienogest and Levonorgestrel-releasing Intrauterine System was used for prevention of complications of Intrauterine System
{"title":"Combined administration of Dienogest and Levonorgestrel – Releasing Intrauterine System Mirena","authors":"K. Tokhunts, A. Khudaverdyan, N.B. Abgaryan, N. Nahapetyan, V. Manvelyan","doi":"10.56936/18290825-2022.16.3-86","DOIUrl":"https://doi.org/10.56936/18290825-2022.16.3-86","url":null,"abstract":"Objectives: Intrauterine hormone-releasing systems are now widely applied to treat metrorrhagia (polymenorrhea), endometrial hyperplasia and adenomyosis. \u0000In previous works we found that risk factors for expulsion of intrauterine device, besides the deformation of the uterine cavity, was the expansion of uterine cavity area > 9 cm2, associated with increased distance between tubal angles >4.5 cm and after the insertion of Levonorgestrel-releasing Intrauterine System (Mirena), among the patients with indicated parameters of uterine cavity, the expulsion reached 90%. Another widely used medicine for treatment of metrorrhagia (polymenorrhea), endometrial hyperplasia and adenomyosis is dienogest (Vizanna). The objective of this study is to explore the influence of combined administration of dienogest and Levonorgestrel- releasing Intrauterine System with the purpose of prevention of complications and side effects of the Intrauterine System.\u0000Study design: This prospective study includes 32 patients with previous Levonorgestrel-releasing Intrauterine System expultions whom Dienogest 2mg daily has been administered within 6 months. \u0000Results: Ultrasound transformation of a myometrium and uterine cavity in 6 months after Vizanna administration was manifested by minimization of uterine cavity and reduction of distance between tubal angles. Mirena was inserted to these patients again. \u0000Within 12 months of monitoring any case of expulsion was not observed.\u0000Conclusions: According to the data received, the combined consistent and simultaneous administration of Dienogest and Mirena reduces the possibility of Intrauterine System expulsion and decreases side effects of the Intrauterine System.\u0000Implication statement: Combined consistent and simultaneous administration of Dienogest and Levonorgestrel-releasing Intrauterine System was used for prevention of complications of Intrauterine System","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127129436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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