Pub Date : 2023-07-09DOI: 10.56936/18290825-2023.17.f-98
F. Tkhruni, A. Israyelyan
Abstract This paper presents the comparative characteristics of the antimicrobial activity of selected lactic acid bacteria strains and antibiotics. The metabiotics of probiotic lactic acid bacteria inhibited the growth of pathogenic, conditionally pathogenic bacteria, different etiology antibiotic resistant bacteria such as Salmonella sp., E. coli, Proteus mirabilis Pasteurella spp., Clostridium sp., Streptococcus sp., Staphylococcus aureus, Shigella sp., Yersinia enterocolitica, Bacillus cereus with different efficiency depending on pathogens isolation sources. It was shown that bacteriocins of lactic acid bacteria in the same concentration did not affect growth of the commensal microbiota strains, belonging to different genera and species. Lactobacillus and Enterococcus genera showed high sensitivity to investigated antibiotics (about 70%). Among all studied LAB strains of Enterococcus genus, some strains were shown to synthesize polysaccharides. The antimicrobial activity of isolated polysaccharides from Enterococcus faecium К Э-14, Enterococcus faecium К Э-5, Enterococcus lactic acid bacteria. Sp. К Э-9, Enterococcus lactic acid bacteria sp. К Э-6 strains was investigated. It was found that only polysaccharides isolated from Enterococcus faecium К Э-14 and Enterococcus faecium К Э-5 strains show an antimicrobial effect. The Enterococcus faecium КЭ-5 (MDC 9662) lactic acid bacteria strain was selected which produce protein-like substances and disaccharide polymers with antimicrobial activity, consist of glucose and galactose. The growth suppression of different Kl. pneumonia and St. pneumonia strains causing pneumonia by antimicrobial preparations of lactic acid bacteria was shown. The highest antimicrobial activity (100%) was observed when the antimicrobial preparations obtained after cultivation of lactic acid bacteria strains of the Enterococcus genus. The activity depends on the source of isolation of pathogens from a patient. The selected strains can be recommended for the creation of probiotic preparations with targeted purposes.
摘要 本文介绍了所选乳酸菌菌株与抗生素抗菌活性的比较特性。益生乳酸菌的代谢物对致病菌、条件致病菌、不同病原的抗生素耐药菌如沙门氏菌属、大肠杆菌属、变形杆菌属、巴斯德氏菌属、梭状芽孢杆菌属、链球菌属、金黄色葡萄球菌属、志贺氏菌属、小肠结肠耶尔森菌属、蜡样芽孢杆菌属等的生长有抑制作用，抑制效率因病原体分离来源而异。研究表明，相同浓度的乳酸菌细菌素不会影响属于不同菌属和菌种的共生微生物群菌株的生长。乳酸菌属和肠球菌属对所研究的抗生素表现出较高的敏感性（约 70%）。在所有研究的肠球菌属 LAB 菌株中，有些菌株能合成多糖。从粪肠球菌 К Э-14、粪肠球菌 К Э-5、乳酸肠球菌 Enterococcus lactic acid bacteria.Sp.КЭ-9，乳酸肠球菌sp.К Э-6菌株进行了研究。研究发现，只有从粪肠球菌К Э-14和粪肠球菌К Э-5菌株中分离出的多糖具有抗菌作用。筛选出的粪肠球菌КЭ-5（MDC 9662）乳酸菌株能产生蛋白样物质和具有抗菌活性的双糖聚合物，由葡萄糖和半乳糖组成。结果表明，乳酸菌抗菌制剂能抑制引起肺炎的不同克氏肺炎菌株和圣肺炎菌株的生长。在培养肠球菌属乳酸菌菌株后获得的抗菌制剂的抗菌活性最高（100%）。抗菌活性取决于从患者体内分离病原体的来源。所选菌株可推荐用于制作有针对性的益生菌制剂。
{"title":"COMPARATIVE ANTIMICROBIAL ACTIVITY OF SOME METABIOTICS SYNTHESIZED BY LACTIC ACID BACTERIA","authors":"F. Tkhruni, A. Israyelyan","doi":"10.56936/18290825-2023.17.f-98","DOIUrl":"https://doi.org/10.56936/18290825-2023.17.f-98","url":null,"abstract":"Abstract This paper presents the comparative characteristics of the antimicrobial activity of selected lactic acid bacteria strains and antibiotics. The metabiotics of probiotic lactic acid bacteria inhibited the growth of pathogenic, conditionally pathogenic bacteria, different etiology antibiotic resistant bacteria such as Salmonella sp., E. coli, Proteus mirabilis Pasteurella spp., Clostridium sp., Streptococcus sp., Staphylococcus aureus, Shigella sp., Yersinia enterocolitica, Bacillus cereus with different efficiency depending on pathogens isolation sources. It was shown that bacteriocins of lactic acid bacteria in the same concentration did not affect growth of the commensal microbiota strains, belonging to different genera and species. Lactobacillus and Enterococcus genera showed high sensitivity to investigated antibiotics (about 70%). Among all studied LAB strains of Enterococcus genus, some strains were shown to synthesize polysaccharides. The antimicrobial activity of isolated polysaccharides from Enterococcus faecium К Э-14, Enterococcus faecium К Э-5, Enterococcus lactic acid bacteria. Sp. К Э-9, Enterococcus lactic acid bacteria sp. К Э-6 strains was investigated. It was found that only polysaccharides isolated from Enterococcus faecium К Э-14 and Enterococcus faecium К Э-5 strains show an antimicrobial effect. The Enterococcus faecium КЭ-5 (MDC 9662) lactic acid bacteria strain was selected which produce protein-like substances and disaccharide polymers with antimicrobial activity, consist of glucose and galactose. The growth suppression of different Kl. pneumonia and St. pneumonia strains causing pneumonia by antimicrobial preparations of lactic acid bacteria was shown. The highest antimicrobial activity (100%) was observed when the antimicrobial preparations obtained after cultivation of lactic acid bacteria strains of the Enterococcus genus. The activity depends on the source of isolation of pathogens from a patient. The selected strains can be recommended for the creation of probiotic preparations with targeted purposes.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139361271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-08DOI: 10.56936/18290825-2023.17.f-17
K. Alshehri, N. Morsi
Abstract Introduction: Bullying at the workplace can be a source of stress that affects mental wellbeing. Mental well-being has been acknowledged as a significant factor that can impact the individual’s ability to cope with the moderate stresses of life to enhance their effective functioning to work productively, contribute to their workplace and profession, and realize their potential. Purpose: The present study aimed to investigate the correlation between nurses’ exposure to workplace bullying and their mental well-being. Material and methods: A descriptive cross-sectional and correlational design was utilized, and 328 nurses working in the first cluster of the Ministry of Health in Jeddah, Saudi Arabia participated in the present study. Data were collected using the Negative Act QuestionnaireRevised and Warwick-Edinburgh Mental Well-being Scale. Results: The results showed that workplace bullying was high and prevalent as more than two-thirds (70.7%) of the participants were sometimes or severely bullied. At the same time, 54% of the participants have average or poor mental well-being. Furthermore, there was a significant inverse correlation between workplace bullying and nurses’ mental well-being. Conclusion: The present study emphasizes the need to solve this issue by rise nursing administration awareness and establishing educational programs for nurses in order to minimize the adverse effects of workplace bullying and foster a safe workplace climate for nurses.
{"title":"THE EFFECT OF WORKPLACE BULLYING ON NURSES’ MENTAL WELL-BEING IN SAUDI ARABIA","authors":"K. Alshehri, N. Morsi","doi":"10.56936/18290825-2023.17.f-17","DOIUrl":"https://doi.org/10.56936/18290825-2023.17.f-17","url":null,"abstract":"Abstract Introduction: Bullying at the workplace can be a source of stress that affects mental wellbeing. Mental well-being has been acknowledged as a significant factor that can impact the individual’s ability to cope with the moderate stresses of life to enhance their effective functioning to work productively, contribute to their workplace and profession, and realize their potential. Purpose: The present study aimed to investigate the correlation between nurses’ exposure to workplace bullying and their mental well-being. Material and methods: A descriptive cross-sectional and correlational design was utilized, and 328 nurses working in the first cluster of the Ministry of Health in Jeddah, Saudi Arabia participated in the present study. Data were collected using the Negative Act QuestionnaireRevised and Warwick-Edinburgh Mental Well-being Scale. Results: The results showed that workplace bullying was high and prevalent as more than two-thirds (70.7%) of the participants were sometimes or severely bullied. At the same time, 54% of the participants have average or poor mental well-being. Furthermore, there was a significant inverse correlation between workplace bullying and nurses’ mental well-being. Conclusion: The present study emphasizes the need to solve this issue by rise nursing administration awareness and establishing educational programs for nurses in order to minimize the adverse effects of workplace bullying and foster a safe workplace climate for nurses.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139361398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-05DOI: 10.56936/18290825-2023.17.3-95
A.A. Alhoqail, S.M. Alsaad
Abstract The present study aims to investigate the association between postpartum depression and sleep quality and its related factors. A descriptive cross-sectional study was conducted in the period between January and March 2020. A sample of 204 women in Saudi Arabia were recruited from the “Well-Baby Clinic” affiliated to King Abdul Aziz Medical City. Both Pittsburgh sleep quality index and Edinburgh postnatal depression scale were used to assess the sleep quality and postpartum depression, respectively. Descriptive statistics and Chi-Square analysis was performed to examine the association between postpartum depression and sleep quality. The study results showed that there was significant association between postpartum depression and subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbance, use of sleep medications and daytime dysfunction (p<0.05). Furthermore, the study revealed that maternal complications during pregnancy and/or delivery, the chosen mode of feeding, usage of painkillers, and post-delivery complications for the child (such as hypoxia) were factors influencing the postpartum depression among the surveyed women. The study concluded that women having postpartum depression are experiencing poor sleep quality. As a result, the study recommends increasing the awareness and knowledge of Saudi women concerning postpartum depression, alongside providing them with specific coping strategies to proficiently manage and alleviate the consequences of postpartum depression.
{"title":"ASSOCIATION BETWEEN POSTPARTUM DEPRESSION AND SLEEP QUALITY AND ITS RELATED FACTORS","authors":"A.A. Alhoqail, S.M. Alsaad","doi":"10.56936/18290825-2023.17.3-95","DOIUrl":"https://doi.org/10.56936/18290825-2023.17.3-95","url":null,"abstract":"Abstract The present study aims to investigate the association between postpartum depression and sleep quality and its related factors. A descriptive cross-sectional study was conducted in the period between January and March 2020. A sample of 204 women in Saudi Arabia were recruited from the “Well-Baby Clinic” affiliated to King Abdul Aziz Medical City. Both Pittsburgh sleep quality index and Edinburgh postnatal depression scale were used to assess the sleep quality and postpartum depression, respectively. Descriptive statistics and Chi-Square analysis was performed to examine the association between postpartum depression and sleep quality. The study results showed that there was significant association between postpartum depression and subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbance, use of sleep medications and daytime dysfunction (p<0.05). Furthermore, the study revealed that maternal complications during pregnancy and/or delivery, the chosen mode of feeding, usage of painkillers, and post-delivery complications for the child (such as hypoxia) were factors influencing the postpartum depression among the surveyed women. The study concluded that women having postpartum depression are experiencing poor sleep quality. As a result, the study recommends increasing the awareness and knowledge of Saudi women concerning postpartum depression, alongside providing them with specific coping strategies to proficiently manage and alleviate the consequences of postpartum depression.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139370853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-05DOI: 10.56936/18290825-2023.17.3-59
T. Ghochikyan
Abstract A method has been proposed for the preparation of 4-hydroxybutanoic acid hydrazides for the first time. It has been established that the target products are obtained by the interaction of 2-substituted (H, alkyl, aralkyl, allyl, etc.)-4-substituted-4-butanolides with 85% aqueous solution hydrazine hydrate. Testing was carried out on white mongrel mice and reliably shown that the introduction of a hydroxypropyl residue into the composition of the synthesized hydrazides leads to new properties, namely hypotensive activity, not previously observed in compounds class of carboxylic acid hydrazides of various structures. The most active compounds have been selected and tested in rats and cats. It has been established that the lethal dose (lethal doses 50) of the proposed compounds ranges from 550-762 mg/kg and they exhibit superior activity compared to those used in the medical preparation “Dibazol”. In order to find new useful properties in a series of gamma-hydroxy acid hydrazides, their antioxidant features were studied by the method of competitive reactions. As a competitive acceptor, 4-nitroso-N,N-dimethylaniline was used. According to the rate of discoloration of the last the reactivity of H radicals with respect to the studied compounds was determined. H radicals were initiated by photolysis of hydrogen peroxide (conc, 10-3 mol/l), under exposure to ultraviolet radiation, at a wavelength of 313 nm. Initiation rate H radicals were measured by the rate of change in the optical density of para-Nitroso-N,Ndimethyl aniline in distilled water and in the presence of the studied compounds. As a result of the research, it was found that all compounds of this series have antioxidant properties, and some of them are comparable with renowned antioxidant vitamin C.
摘要 首次提出了一种制备 4-羟基丁酸酰肼的方法。已确定目标产物是由 2-取代的（H、烷基、芳基、烯丙基等）-4-取代-4-丁醇内酯与 85%的水合肼水溶液相互作用得到的。在白种杂种小鼠身上进行了测试，结果可靠地表明，在合成的肼类化合物中引入羟丙基残基会产生新的特性，即降血压活性，这是以前在各种结构的羧酸肼类化合物中没有观察到的。我们选择了活性最强的化合物，并在大鼠和猫身上进行了测试。结果表明，拟议化合物的致死剂量（致死剂量 50）为 550-762 毫克/千克，与医用制剂 "地巴唑 "中使用的化合物相比，它们表现出更强的活性。为了在一系列γ-羟基酸酰肼中发现新的有用特性，我们采用竞争反应的方法研究了它们的抗氧化特性。作为竞争性受体，使用了 4-亚硝基-N,N-二甲基苯胺。根据最后的褪色率，确定了 H 自由基与所研究化合物的反应性。在波长为 313 纳米的紫外线照射下，过氧化氢（浓度为 10-3 摩尔/升）发生光解，从而引发 H 自由基。H 自由基的引发率是通过蒸馏水中对硝基-N,N 二甲基苯胺的光密度变化率和所研究化合物存在时的光密度变化率来测量的。研究结果发现，该系列的所有化合物都具有抗氧化性，其中一些化合物的抗氧化性可与著名的抗氧化剂维生素 C 相媲美。
{"title":"HYPOTENSIVE AND ANTIOXIDANT PROPERTIES OF GAMMA-HYDROXY ACID HYDRAZIDES","authors":"T. Ghochikyan","doi":"10.56936/18290825-2023.17.3-59","DOIUrl":"https://doi.org/10.56936/18290825-2023.17.3-59","url":null,"abstract":"Abstract A method has been proposed for the preparation of 4-hydroxybutanoic acid hydrazides for the first time. It has been established that the target products are obtained by the interaction of 2-substituted (H, alkyl, aralkyl, allyl, etc.)-4-substituted-4-butanolides with 85% aqueous solution hydrazine hydrate. Testing was carried out on white mongrel mice and reliably shown that the introduction of a hydroxypropyl residue into the composition of the synthesized hydrazides leads to new properties, namely hypotensive activity, not previously observed in compounds class of carboxylic acid hydrazides of various structures. The most active compounds have been selected and tested in rats and cats. It has been established that the lethal dose (lethal doses 50) of the proposed compounds ranges from 550-762 mg/kg and they exhibit superior activity compared to those used in the medical preparation “Dibazol”. In order to find new useful properties in a series of gamma-hydroxy acid hydrazides, their antioxidant features were studied by the method of competitive reactions. As a competitive acceptor, 4-nitroso-N,N-dimethylaniline was used. According to the rate of discoloration of the last the reactivity of H radicals with respect to the studied compounds was determined. H radicals were initiated by photolysis of hydrogen peroxide (conc, 10-3 mol/l), under exposure to ultraviolet radiation, at a wavelength of 313 nm. Initiation rate H radicals were measured by the rate of change in the optical density of para-Nitroso-N,Ndimethyl aniline in distilled water and in the presence of the studied compounds. As a result of the research, it was found that all compounds of this series have antioxidant properties, and some of them are comparable with renowned antioxidant vitamin C.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139370869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-05DOI: 10.56936/18290825-2023.17.3-74
M. Sani, M.E. Hokmabadi
Abstract Plants are one of the important and valuable sources in the preparation of medicines, both in traditional medicine and in the form of pure products. Ginger is obtained from a yellow plant with purple veins with the scientific name Zingiber officinale. Although ginger is usually referred to as the root of the plant, actually the part used is the swollen underground stem called the rhizome. The aroma and flavor of ginger are due to the presence of two types of volatile oils and non-volatile pungent compounds. The biologically active components of ginger are classified in the second category, among the most important molecules in this category, are gingerol and shogaol, which cause a pungent sensation in the mouth. Most properties of ginger are attributed to non-volatile components with a spicy taste. The properties of these substances can be reduced blood sugar, weight loss, increased blood insulin, effect on blood coagulation, effect on blood pressure, reduction of complications of gastrointestinal diseases, reduction of nausea caused by pregnancy, or the use of chemotherapy drugs, the protective effect of the tissue against chemical and radio damage with anti-inflammatory properties, antioxidant properties, antibacterial and antifungal properties, especially Candida albicans, anti-cancer properties through antioxidant and anti-inflammatory properties. This study aimed to describe the ginger plant and its active ingredients and some features including anti-inflammatory effects, anti-oxidative effects, anti-cancer effects, and so on.
{"title":"DESCRIBING THE GINGER PLANT AND ITS EFFECTIVE INGREDIENTS ALONG WITH ITS THERAPEUTIC PROPERTIES IN VARIOUS COMPLICATIONS","authors":"M. Sani, M.E. Hokmabadi","doi":"10.56936/18290825-2023.17.3-74","DOIUrl":"https://doi.org/10.56936/18290825-2023.17.3-74","url":null,"abstract":"Abstract Plants are one of the important and valuable sources in the preparation of medicines, both in traditional medicine and in the form of pure products. Ginger is obtained from a yellow plant with purple veins with the scientific name Zingiber officinale. Although ginger is usually referred to as the root of the plant, actually the part used is the swollen underground stem called the rhizome. The aroma and flavor of ginger are due to the presence of two types of volatile oils and non-volatile pungent compounds. The biologically active components of ginger are classified in the second category, among the most important molecules in this category, are gingerol and shogaol, which cause a pungent sensation in the mouth. Most properties of ginger are attributed to non-volatile components with a spicy taste. The properties of these substances can be reduced blood sugar, weight loss, increased blood insulin, effect on blood coagulation, effect on blood pressure, reduction of complications of gastrointestinal diseases, reduction of nausea caused by pregnancy, or the use of chemotherapy drugs, the protective effect of the tissue against chemical and radio damage with anti-inflammatory properties, antioxidant properties, antibacterial and antifungal properties, especially Candida albicans, anti-cancer properties through antioxidant and anti-inflammatory properties. This study aimed to describe the ginger plant and its active ingredients and some features including anti-inflammatory effects, anti-oxidative effects, anti-cancer effects, and so on.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139370851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-05DOI: 10.56936/18290825-2023.17.3-105
N.V. Manukyan, G.N. Tamamyan
Abstract Breast cancer is the most common cancer among women worldwide, accounting for approximately 25% of all female cancer cases. Given the increasing impact of breast cancer in developing countries, early detection and timely treatment are crucial in reducing morbidity and mortality associated with the disease. Mammography screening is a well-established method for early detection, as it can identify breast cancer at an early stage when the chances of successful treatment are higher. Mobile mammography screening has the potential to significantly improve early detection and reduce mortality rates associated with breast cancer in developing countries. However, various challenges still impede the full realization of its benefits. This review article aims to identify and explore the challenges and prospects of implementing mobile mammography screening programs in developing countries, and to provide recommendations on how to overcome these obstacles. Overall, the future of mobile mammography screening in developing countries can be promising, with opportunities for technological advancements, increased global cooperation, and ongoing research to further enhance the effectiveness of these programs. By seizing these opportunities and addressing the challenges related to accessibility, affordability, human resources, cultural and social factors, and infrastructure, mobile mammography screening can make a significant impact on the lives of women in developing countries and contribute to reducing global disparities in breast cancer care. Several successful mobile mammography screening projects in low- and middle-income countries showcase the potential for such programs to improve access to early detection services, raise breast cancer awareness, and ultimately reduce breast cancer mortality rates. By adapting best practices and lessons learned from these projects, other low- and middle-income countries can develop and implement mobile mammography screening programs tailored to their unique contexts and resource constraints.
摘要 乳腺癌是全世界妇女最常见的癌症，约占女性癌症病例总数的 25%。鉴于乳腺癌对发展中国家的影响越来越大，早期发现和及时治疗对于降低该疾病的发病率和死亡率至关重要。乳房 X 射线照相筛查是一种行之有效的早期检测方法，因为它可以在早期阶段发现乳腺癌，此时成功治疗的几率更高。在发展中国家，移动乳房 X 射线照相筛查有可能大大提高乳腺癌的早期发现率并降低相关死亡率。然而，各种挑战仍然阻碍着其效益的充分实现。这篇综述文章旨在确定和探讨在发展中国家实施移动乳腺 X 射线照相筛查项目所面临的挑战和前景，并就如何克服这些障碍提出建议。总体而言，发展中国家的移动乳腺 X 光造影筛查前景广阔，技术进步、全球合作的加强以及持续的研究都为进一步提高这些项目的有效性提供了机遇。抓住这些机遇，应对与可及性、可负担性、人力资源、文化和社会因素以及基础设施相关的挑战，流动乳腺 X 光造影筛查就能对发展中国家妇女的生活产生重大影响，并为缩小全球乳腺癌治疗的差距做出贡献。几个在中低收入国家成功开展的移动乳腺 X 射线照相筛查项目展示了此类项目在改善早期检测服务、提高乳腺癌意识以及最终降低乳腺癌死亡率方面的潜力。通过借鉴这些项目的最佳实践和经验教训，其他中低收入国家也可以根据自身的独特国情和资源限制，制定并实施移动乳腺 X 光造影筛查项目。
{"title":"A REVIEW OF CHALLENGES AND PROSPECTS OF MOBILE MAMMOGRAPHY SCREENING IN DEVELOPING COUNTRIES","authors":"N.V. Manukyan, G.N. Tamamyan","doi":"10.56936/18290825-2023.17.3-105","DOIUrl":"https://doi.org/10.56936/18290825-2023.17.3-105","url":null,"abstract":"Abstract Breast cancer is the most common cancer among women worldwide, accounting for approximately 25% of all female cancer cases. Given the increasing impact of breast cancer in developing countries, early detection and timely treatment are crucial in reducing morbidity and mortality associated with the disease. Mammography screening is a well-established method for early detection, as it can identify breast cancer at an early stage when the chances of successful treatment are higher. Mobile mammography screening has the potential to significantly improve early detection and reduce mortality rates associated with breast cancer in developing countries. However, various challenges still impede the full realization of its benefits. This review article aims to identify and explore the challenges and prospects of implementing mobile mammography screening programs in developing countries, and to provide recommendations on how to overcome these obstacles. Overall, the future of mobile mammography screening in developing countries can be promising, with opportunities for technological advancements, increased global cooperation, and ongoing research to further enhance the effectiveness of these programs. By seizing these opportunities and addressing the challenges related to accessibility, affordability, human resources, cultural and social factors, and infrastructure, mobile mammography screening can make a significant impact on the lives of women in developing countries and contribute to reducing global disparities in breast cancer care. Several successful mobile mammography screening projects in low- and middle-income countries showcase the potential for such programs to improve access to early detection services, raise breast cancer awareness, and ultimately reduce breast cancer mortality rates. By adapting best practices and lessons learned from these projects, other low- and middle-income countries can develop and implement mobile mammography screening programs tailored to their unique contexts and resource constraints.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139370808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-05DOI: 10.56936/18290825-2023.17.3-66
H.G. Hovhannisyan
Abstract This investigation was undertaken for in vitro evaluation of the adaptive and probiotic properties of Lactobacillus helveticus MDC 9602, the starter of the Armenian functional sour milk “Narine” widely used for curing gastrointestinal disorders and lowering blood pressure. Lactobacillus helveticus species predominantly are used as starters for production of cheeses and fermented sour milk drinks, but a growing body of scientific evidence shows that some strains belonging to this species possesses health benefits. The adaptive properties of MDC 9602, necessary for bacteria viability in the gastrointestinal tract, involve high tolerance to acids, high auto aggregation and hydrophobicity, but low tolerance to bile (0.3%) and NaCl (2%); it does not hydrolyze bile salts, nor utilizes maltose. L. helveticus MDC 9602 produces antimicrobials sensitive to proteinase K and large amounts of lactic acid, exhibits an antagonistic effect on pathogenic and related bacteria. It is susceptible to many routinely prescribed antibiotics and can considered safe. It is susceptible to many routinely prescribed antibiotics. The beverage “Narine” besides of >1011 CFU/g friendly bacteria, contains a high amount of different proteinases and β-galactosidase, which increases nutritional bioavailability of food. Taking “Narine” prevents gastrointestinal infections, modulates the host’s immune response, improves the composition of the gut microbiota and lowering high blood pressure. Most of the listed properties of L. helveticus MDC 9602 do not appear in media other than milk. Thus, it was possible to show that the fermented milk product “Narine”, along with live friendly bacteria, also contains a high amount of various hydrolases,lactic acid and bioactive molecules that improve human health and its starter L. helveticus MDC 9602 can be included among the bacterial species commonly considered as probiotics and starter cultures for the production of high quality nutraceuticals.
{"title":"HEALTH PROMOTING POTENTIALS OF ARMENIAN FUNCTIONAL SOUR MILK “NARINE” AND ITS STARTER LACTOBACILLUS HELVETICUS MDC 9602","authors":"H.G. Hovhannisyan","doi":"10.56936/18290825-2023.17.3-66","DOIUrl":"https://doi.org/10.56936/18290825-2023.17.3-66","url":null,"abstract":"Abstract This investigation was undertaken for in vitro evaluation of the adaptive and probiotic properties of Lactobacillus helveticus MDC 9602, the starter of the Armenian functional sour milk “Narine” widely used for curing gastrointestinal disorders and lowering blood pressure. Lactobacillus helveticus species predominantly are used as starters for production of cheeses and fermented sour milk drinks, but a growing body of scientific evidence shows that some strains belonging to this species possesses health benefits. The adaptive properties of MDC 9602, necessary for bacteria viability in the gastrointestinal tract, involve high tolerance to acids, high auto aggregation and hydrophobicity, but low tolerance to bile (0.3%) and NaCl (2%); it does not hydrolyze bile salts, nor utilizes maltose. L. helveticus MDC 9602 produces antimicrobials sensitive to proteinase K and large amounts of lactic acid, exhibits an antagonistic effect on pathogenic and related bacteria. It is susceptible to many routinely prescribed antibiotics and can considered safe. It is susceptible to many routinely prescribed antibiotics. The beverage “Narine” besides of >1011 CFU/g friendly bacteria, contains a high amount of different proteinases and β-galactosidase, which increases nutritional bioavailability of food. Taking “Narine” prevents gastrointestinal infections, modulates the host’s immune response, improves the composition of the gut microbiota and lowering high blood pressure. Most of the listed properties of L. helveticus MDC 9602 do not appear in media other than milk. Thus, it was possible to show that the fermented milk product “Narine”, along with live friendly bacteria, also contains a high amount of various hydrolases,lactic acid and bioactive molecules that improve human health and its starter L. helveticus MDC 9602 can be included among the bacterial species commonly considered as probiotics and starter cultures for the production of high quality nutraceuticals.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139370830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-05DOI: 10.56936/18290825-2023.17.3-119
W.A. Qadah
Abstract The aim of this study was an attempt to explore the level of using social media among the university students at both Fakeeh College for Medical Sciences and King Abdul-Aziz University by examining the correlation between their average social media usage and their self-esteem and life satisfaction. A cross- sectional descriptive design was used in the study to achieve the aim. Convenience sample for 110 students was used. This study was conducted in King Abdul Aziz University and Fakeeh College for Medical Sciences in Jeddah-Saudi Arabia. Three tools were used in this study as: Social Media Addiction Questionnaire, Rosenberg Self-Esteem Scale and Satisfaction with Life Scale. There was a highly statistically significant relation between total social media addiction scale and their age, marital status, and study setting. In addition, there was a highly statistically significant relation between total self-esteem score and their marital status, as the single students had the highest self-esteem mean score among the studied students. Moreover, there was a highly statistically significant relation between total life satisfaction and their study setting. The majority of students affected by social media addiction. There was a negative significant relationship between the overall use of social networks and self-esteem and life satisfaction of students. Moreover, there was a highly positive association between self-esteem and life satisfaction. Based on the study results, it is advisable to promote an awareness program for students that would focus on recognizing the challenges associated with social media addiction. Furthermore, it is recommended to implement a variety of interventions aimed at managing addictive behaviors such as mediating techniques, breathing exercise, therapeutic methods as group therapy, cognitive behavioural therapy, or counseling therapy. By offering these interventions, individuals struggling with social media addiction can be better equipped to effectively address and manage their addictive behaviors
{"title":"THE IMPACT OF SOCIAL MEDIA ADDICTION ON SELF-ESTEEM AND LIFE SATISFACTION AMONG STUDENTS IN KING ABDUL AZIZ UNIVERSITY AND FAKEEH COLLEGE FOR MEDICAL SCIENCES IN JEDDAH: CROSS-SECTIONAL STUDY","authors":"W.A. Qadah","doi":"10.56936/18290825-2023.17.3-119","DOIUrl":"https://doi.org/10.56936/18290825-2023.17.3-119","url":null,"abstract":"Abstract The aim of this study was an attempt to explore the level of using social media among the university students at both Fakeeh College for Medical Sciences and King Abdul-Aziz University by examining the correlation between their average social media usage and their self-esteem and life satisfaction. A cross- sectional descriptive design was used in the study to achieve the aim. Convenience sample for 110 students was used. This study was conducted in King Abdul Aziz University and Fakeeh College for Medical Sciences in Jeddah-Saudi Arabia. Three tools were used in this study as: Social Media Addiction Questionnaire, Rosenberg Self-Esteem Scale and Satisfaction with Life Scale. There was a highly statistically significant relation between total social media addiction scale and their age, marital status, and study setting. In addition, there was a highly statistically significant relation between total self-esteem score and their marital status, as the single students had the highest self-esteem mean score among the studied students. Moreover, there was a highly statistically significant relation between total life satisfaction and their study setting. The majority of students affected by social media addiction. There was a negative significant relationship between the overall use of social networks and self-esteem and life satisfaction of students. Moreover, there was a highly positive association between self-esteem and life satisfaction. Based on the study results, it is advisable to promote an awareness program for students that would focus on recognizing the challenges associated with social media addiction. Furthermore, it is recommended to implement a variety of interventions aimed at managing addictive behaviors such as mediating techniques, breathing exercise, therapeutic methods as group therapy, cognitive behavioural therapy, or counseling therapy. By offering these interventions, individuals struggling with social media addiction can be better equipped to effectively address and manage their addictive behaviors","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139370864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-14DOI: 10.56936/18290825-2023.17.3-20
O.V. Gaisenok
Abstract The objective of this study was to analyze clinical cases of myocardial infarction occurring at a young age within a sample of patients from the Duplex registry database (n=2548), to assess the prevalence of major risk factors and comorbid conditions. Specifically, patients under the age of 45 were selected (n=351). Patients who experienced post-myocardial infarction were identified using data from clinical and anamnestic records, in accordance with the International Classification of Diseases, 10th Revision - their proportion was 0.85% (n=3) (all male patients; mean age 35 ± 1.4 years). Two out of three were smokers and had other traditional risk factors such as hypertension, dyslipidemia and overweight. In addition, patients had important comorbid diseases: morbid obesity, lymphogranulomatosis, hepatitis with transformation to liver cirrhosis. All of them had confirmed atherosclerosis of the arteries of the lower extremities. Probably one of the main precipitating factors for myocardial infarction development in them was a hereditary predisposition due to a burdened family history, although none of them met the Dutch Lipid Clinics Network criteria for familial hyperlipidemia and none of them underwent genetic testing. A better understanding of risk factors and pathophysiological pathways in young adults may improve strategies for both preventing and treating myocardial infarction in this patient group. Raising awareness can help identify young individuals at higher risk and determine primary prevention strategies. However, the identification of patients with premature coronary artery disease by screening for traditional risk factors does not effectively identify patients at risk prior to the diagnosis of myocardial infarction. Additional studies are needed to evaluate new risk factors and apply additional imaging techniques so that these patients can be identified before myocardial infarction occurs.
{"title":"MYOCARDIAL INFARCTION AT A YOUNG AGE: ANALYSIS OF CLINICAL CASES FROM THE DUPLEX REGISTRY DATABASE","authors":"O.V. Gaisenok","doi":"10.56936/18290825-2023.17.3-20","DOIUrl":"https://doi.org/10.56936/18290825-2023.17.3-20","url":null,"abstract":"Abstract The objective of this study was to analyze clinical cases of myocardial infarction occurring at a young age within a sample of patients from the Duplex registry database (n=2548), to assess the prevalence of major risk factors and comorbid conditions. Specifically, patients under the age of 45 were selected (n=351). Patients who experienced post-myocardial infarction were identified using data from clinical and anamnestic records, in accordance with the International Classification of Diseases, 10th Revision - their proportion was 0.85% (n=3) (all male patients; mean age 35 ± 1.4 years). Two out of three were smokers and had other traditional risk factors such as hypertension, dyslipidemia and overweight. In addition, patients had important comorbid diseases: morbid obesity, lymphogranulomatosis, hepatitis with transformation to liver cirrhosis. All of them had confirmed atherosclerosis of the arteries of the lower extremities. Probably one of the main precipitating factors for myocardial infarction development in them was a hereditary predisposition due to a burdened family history, although none of them met the Dutch Lipid Clinics Network criteria for familial hyperlipidemia and none of them underwent genetic testing. A better understanding of risk factors and pathophysiological pathways in young adults may improve strategies for both preventing and treating myocardial infarction in this patient group. Raising awareness can help identify young individuals at higher risk and determine primary prevention strategies. However, the identification of patients with premature coronary artery disease by screening for traditional risk factors does not effectively identify patients at risk prior to the diagnosis of myocardial infarction. Additional studies are needed to evaluate new risk factors and apply additional imaging techniques so that these patients can be identified before myocardial infarction occurs.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"518 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135837781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.56936/18290825-2023.17.3-4
AVAGYAN M., KAGER L., Zohrabyan D.
Abstract Giant cell tumor of bone is a rare neoplasm characterized by its unpredictable behavior, possible malignant transformations, and/or lung metastases. Surgery is the treatment of choice. In unresectable or metastatic cases, treatment with denosumab is a new treatment option. In October 2015, a 14-year-old female presented with cachexia, dysphagia, diplopia, discoordination, strabismus, and multiple cranial nerve palsies. An MRI examination revealed an intra-extracranial mass arising from C2 vertebrae, compressing the medulla oblongata and the left cerebellar hemisphere, invading the sphenoid bone and nasopharynges. The biopsy results revealed the presence of a giant cell tumor of bone. The first surgical resection was incomplete because of tumor location (cranial nerve and vertebral artery involvement). The patient received local radiotherapy with 50.4Gy, but the patient’s condition worsened during this period and subsequent MRI examination showed disease progression. In March 2016, the administration of denosumab at a dosage of 120 mg every 4 weeks was initiated, and induced rapid clinical improvement and radiographically proven partial response. Disease was under control for three years until March 2019, when she returned with clinical symptoms of diplopia and severe headache. MRI showed local tumor progression. Repeated biopsy revealed an undifferentiated pleomorphic sarcoma. Two cycles of chemotherapy with Ifosfamide/Doxorubicin were administered, but MRI after chemotherapy showed marked tumor progression. The patient received palliative care and died due to disease progression in December 2019 – 4 years after initial diagnosis. To our knowledge, this is the youngest patient ever reported with a skull base Giant cell tumor initially responding to denosumab for 3 years but progressing to chemotherapy resistant undifferentiated pleomorphic sarcoma.
{"title":"Secondary Malignancy In Giant Cell Tumor Of The Skull Base After Denosumab Treatment: Case Report","authors":"AVAGYAN M., KAGER L., Zohrabyan D.","doi":"10.56936/18290825-2023.17.3-4","DOIUrl":"https://doi.org/10.56936/18290825-2023.17.3-4","url":null,"abstract":"Abstract Giant cell tumor of bone is a rare neoplasm characterized by its unpredictable behavior, possible malignant transformations, and/or lung metastases. Surgery is the treatment of choice. In unresectable or metastatic cases, treatment with denosumab is a new treatment option. In October 2015, a 14-year-old female presented with cachexia, dysphagia, diplopia, discoordination, strabismus, and multiple cranial nerve palsies. An MRI examination revealed an intra-extracranial mass arising from C2 vertebrae, compressing the medulla oblongata and the left cerebellar hemisphere, invading the sphenoid bone and nasopharynges. The biopsy results revealed the presence of a giant cell tumor of bone. The first surgical resection was incomplete because of tumor location (cranial nerve and vertebral artery involvement). The patient received local radiotherapy with 50.4Gy, but the patient’s condition worsened during this period and subsequent MRI examination showed disease progression. In March 2016, the administration of denosumab at a dosage of 120 mg every 4 weeks was initiated, and induced rapid clinical improvement and radiographically proven partial response. Disease was under control for three years until March 2019, when she returned with clinical symptoms of diplopia and severe headache. MRI showed local tumor progression. Repeated biopsy revealed an undifferentiated pleomorphic sarcoma. Two cycles of chemotherapy with Ifosfamide/Doxorubicin were administered, but MRI after chemotherapy showed marked tumor progression. The patient received palliative care and died due to disease progression in December 2019 – 4 years after initial diagnosis. To our knowledge, this is the youngest patient ever reported with a skull base Giant cell tumor initially responding to denosumab for 3 years but progressing to chemotherapy resistant undifferentiated pleomorphic sarcoma.","PeriodicalId":353660,"journal":{"name":"THE NEW ARMENIAN MEDICAL JOURNAL","volume":"150 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135263513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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