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Fixed and preassigned-time synchronization of drive-response networks with discontinuous activation functions 具有不连续激活功能的驱动响应网络的固定和预分配时间同步
Q4 Engineering Pub Date : 2022-11-01 DOI: 10.3724/sp.j.1249.2022.06709
Xingrui Li, Yuzhu Xiao, Xueli Song, Nannan Zhao, Dongxin Shi, Meihua Shan
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引用次数: 0
Activity prediction of anti-cancer drug candidate ERα inhibitor 抗癌候选药物ERα抑制剂的活性预测
Q4 Engineering Pub Date : 2022-09-01 DOI: 10.3724/sp.j.1249.2022.05529
Yulan Xia, Jiming Xie, Yajing Wang, Mengyuan Lu, Jinrui Wang, Yaqin Qin
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引用次数: 0
Deep-learning-based proxy model for forecasting gas flooding performance of fractured well pattern in tight oil reservoirs 基于深度学习的致密油藏裂缝性井网气驱动态预测代理模型
Q4 Engineering Pub Date : 2022-09-01 DOI: 10.3724/sp.j.1249.2022.05559
X. Zhu, Bin Yuan, Yuanhui Tong, Ming Zhao, He Zheng, Xiulei Liu
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引用次数: 0
Preparation of high purity germanium single crystal and analysis of dislocation density 高纯锗单晶的制备及位错密度分析
Q4 Engineering Pub Date : 2022-09-01 DOI: 10.3724/sp.j.1249.2022.05504
Xin Hao, Lin Gan, Shipeng Hu, Q. Luo, Zhengxin Wu, Jian Zhong, Haige Zhao, Huibin Sun
Abstract: High purity germanium detector plays an important role in the field of radiation detection. High purity germanium with 13N purity and dislocation density between 100 ~ 10 000 cm-2 was successfully prepared through zone melting purification and single crystal growth. In the zone melting experiment, the self-made horizontal zone furnace is used to achieve the purification requirements through 20 ~ 50 times of zone melting in the environment of high-purity hydrogen. The single crystal is grown by Czochralski method along the [100] direction in high-purity hydrogen environment with effective length > 50 mm and effective diameter > 30 mm. The dislocation density measurement adopts the etching method. The acid etching solution is used to etch the crystal (100) surface and the number of the etch pits is counted. The results show that the dislocation densities at 25, 50 and 72 mm from the head of the single crystal are 2 537, 3 425 and 4 075 cm-2 respectively. These results indicate that the dislocation density before 72 mm meets the requirements for the preparation of high-purity germanium detectors. The research can provide reference for the preparation of high purity germanium single crystal.
摘要:高纯锗探测器在辐射探测领域占有重要地位。通过区熔提纯和单晶生长,成功制备了纯度为13N,位错密度在100 ~ 10 000 cm-2之间的高纯锗。在区域熔炼实验中,采用自制卧式区域炉,在高纯氢气环境下,经过20 ~ 50次区域熔炼,达到净化要求。采用Czochralski法在高纯氢环境下沿[100]方向生长单晶,有效长> 50 mm,有效直径> 30 mm。位错密度测量采用蚀刻法。采用酸性蚀刻液对晶体(100)表面进行蚀刻,并对蚀刻坑的个数进行计数。结果表明:在距单晶头部25、50和72 mm处,位错密度分别为2 537、3 425和4 075 cm-2;这些结果表明,72 mm之前的位错密度满足制备高纯度锗探测器的要求。研究结果可为制备高纯锗单晶提供参考。
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引用次数: 0
Bioactive secondary metabolites from two sponge-derived actinomycetes 两种海绵来源放线菌的生物活性次级代谢产物
Q4 Engineering Pub Date : 2022-09-01 DOI: 10.3724/sp.j.1249.2022.05550
Zhikai Guo, Rong Wang, Weicheng Wu, Ming Li, Wanggui He, Shi-Yin Zhou
Actinomycetes residing in marine habitat are an excellent treasure house of structurally novel and Received: 2022-01-10; Accepted: 2022-06-06; Online (CNKI): 2022-08-09 Foundation: Hainan Provincial Basic and Applied Basic Research Fund for High-Level Talents in Natural Science (2019RC306, 2019RC352); Central Public-Interest Scientific Institution Basal Research Fund for CATAS-ITBB (1630052022028, 1630052022016, 1630052019011); Financial Fund of the Ministry of Agriculture and Rural Affairs of China (NFZX2021) Corresponding author: Associate professor GUO Zhikai. E-mail: guozhikai@itbb.org.cn Associate professor LI Ming. E-mail: liming0898@163.com Citation: GUO Zhikai, WANG Rong, WU Weicheng, et al. Bioactive secondary metabolites from two sponge-derived actinomycetes [J]. Journal of Shenzhen University Science and Engineering, 2022, 39(5): 550-558. (in Chinese) 第 5期 郭志凯,等:两株海绵放线菌产生的抗菌活性产物研究 http://journal.szu.edu.cn bioactive natural products with potent medicinal values. To exploit chemically diverse and bioactive natural products from actinomycetes living in underexplored ecological niche, we isolate a large number of marine actinomycetes from marine sponges, corals, algae, mollusks, sea grasses, and sediments collected from the South China Sea. In order to assess the values of these special marine actinomycetes in the green development of tropical agriculture, we screen the activity of marine actinomycetes against phytopathogenic fungi and bacteria. As a result, we identify two strains of sponge-derived actinobacteria Streptomyces sp. HMH1 and HML1 possessing antagonism effect against tested phytopathogenic microbes. The secondary metabolites produced by these two actinomycete strains and their antiphytopathogenic fungi activity are investigated. The secondary metabolites from the fermentation extract of Streptomyces sp. HMH1 and HML1 are isolated and purified using various chromatography methods including silica gel column, reverse gel column and Sephadex LH-20 column chromatography. The structures of the isolated compounds are characterized by NMR, HR-ESI-MS spectroscopic data analyses and comparison with previously reported data. Three major compounds belonging to the family of actinomycin are purified from the solid fermentation extract of the sponge-derived actinobacterium Streptomyces sp. HMH1. They actinomycin D, actinomycin X2, and actinomycin Xoβ. A compound identified as K-252d belonging to the family of indolocarbazole alkaloid is isolated from the solid fermentation extract of another sponge-derived actinobacterium Streptomyces sp. HML1. The antiphytopathogenic fungi and bacteria activities of these compounds are evaluated against ten species of plant pathogenic fungi including Fusarium oxysporum FOC4, Lasiodiplodia theobromae, Phomopsis caricae-papayae Fetrak&Cif., Corynespora cassiicola, Phytophthora capsica, Pythium aphanidermatum (Edson) Fitzp, Corynespora sp., Fusarium graminearum, Verticillium dahlia, Pestalotiopsis microspo
生活在海洋栖息地的放线菌是结构新颖的优秀宝库,收到时间:2022-01-10;受理日期:2022-06-06;在线(CNKI):2022-08-09基金资助:海南省自然科学高层次人才基础与应用基础研究基金(2019RC3062019RC352);中央公益性科研机构基础研究基金项目(16300520282016300520220161630052019011);中国农业农村部财政资金项目(NFZX2021)通讯作者:郭志凯副教授。电子邮件:guozhikai@itbb.org.cn李明副教授。电子邮件:liming0898@163.com引文:郭志凯,王荣,吴伟成,等。两种海绵状放线菌的生物活性次级代谢产物[J]。深圳大学学报,2022,39(5):550-558。(中文)第 5.期 郭志凯,等:两株海绵放线菌产生的抗菌活性产物研究 http://journal.szu.edu.cn具有强大药用价值的生物活性天然产品。为了从生活在未充分开发的生态位中的放线菌中开发化学多样性和生物活性的天然产物,我们从南海的海绵、珊瑚、藻类、软体动物、海草和沉积物中分离出大量的海洋放线菌。为了评估这些特殊的海洋放线菌在热带农业绿色发展中的价值,我们筛选了海洋放线杆菌对植物病原真菌和细菌的活性。结果,我们鉴定了两株海绵来源的放线菌链霉菌。HMH1和HML1对测试的植物病原微生物具有拮抗作用。研究了这两株放线菌产生的次生代谢产物及其抗真菌致病活性。利用硅胶柱、反相凝胶柱和Sephadex LH-20柱等多种色谱方法,分离纯化了链霉菌发酵提取物中的次生代谢产物HMH1和HML1。通过NMR、HR-ESI-MS光谱数据分析以及与先前报道的数据的比较来表征分离的化合物的结构。从海绵衍生的放线菌链霉菌HMH1的固体发酵提取物中纯化了属于放线菌素家族的三种主要化合物。它们是放线菌素D、放线菌素X2和放线菌毒素Xoβ。从另一种海绵衍生的放线菌链霉菌HML1的固体发酵提取物中分离出一种属于吲哚咔唑生物碱家族的化合物K-252d。评价了这些化合物对10种植物病原真菌的抗植物病原真菌和细菌活性,这些真菌包括尖孢镰刀菌FOC4、席溴Lasiodiplodia、辣椒Phomopsis caricae papayae Fetrak和Cif。,肉桂棒孢菌、辣椒疫霉、无叶腐霉(Edson)Fitzp、棒孢菌属、禾谷镰刀菌、大丽花轮枝菌、微孢子虫和包括水稻黄单胞菌在内的两种植物病原菌。米曲霉和青枯菌。该化合物对农业病原菌的生物活性测试结果表明,放线菌素D对这些被测植物病原真菌和细菌的生长具有抑制活性。其中放线菌素D对植物病原真菌木犀(Lasiodiplodia theobromae)、罂粟(Phomopsis caricae papayae Fetrak&Cif)具有最强的抑制活性。,禾谷镰刀菌(Fusarium graminearum)和辣椒疫霉(Phytophthora capsica)的抑制率分别为(60.09±0.66)%、(48.82±0.66。此外,放线菌素D对植物病原菌米黄单胞菌pv表现出较强的抗菌活性。其抑菌直径分别为(36.00±0.82)mm和(15.00±0.47)mm。这些结果为开发用于农业疾病控制的高效生物防治剂提供了新的化合物和细菌资源。
{"title":"Bioactive secondary metabolites from two sponge-derived actinomycetes","authors":"Zhikai Guo, Rong Wang, Weicheng Wu, Ming Li, Wanggui He, Shi-Yin Zhou","doi":"10.3724/sp.j.1249.2022.05550","DOIUrl":"https://doi.org/10.3724/sp.j.1249.2022.05550","url":null,"abstract":"Actinomycetes residing in marine habitat are an excellent treasure house of structurally novel and Received: 2022-01-10; Accepted: 2022-06-06; Online (CNKI): 2022-08-09 Foundation: Hainan Provincial Basic and Applied Basic Research Fund for High-Level Talents in Natural Science (2019RC306, 2019RC352); Central Public-Interest Scientific Institution Basal Research Fund for CATAS-ITBB (1630052022028, 1630052022016, 1630052019011); Financial Fund of the Ministry of Agriculture and Rural Affairs of China (NFZX2021) Corresponding author: Associate professor GUO Zhikai. E-mail: guozhikai@itbb.org.cn Associate professor LI Ming. E-mail: liming0898@163.com Citation: GUO Zhikai, WANG Rong, WU Weicheng, et al. Bioactive secondary metabolites from two sponge-derived actinomycetes [J]. Journal of Shenzhen University Science and Engineering, 2022, 39(5): 550-558. (in Chinese) 第 5期 郭志凯,等:两株海绵放线菌产生的抗菌活性产物研究 http://journal.szu.edu.cn bioactive natural products with potent medicinal values. To exploit chemically diverse and bioactive natural products from actinomycetes living in underexplored ecological niche, we isolate a large number of marine actinomycetes from marine sponges, corals, algae, mollusks, sea grasses, and sediments collected from the South China Sea. In order to assess the values of these special marine actinomycetes in the green development of tropical agriculture, we screen the activity of marine actinomycetes against phytopathogenic fungi and bacteria. As a result, we identify two strains of sponge-derived actinobacteria Streptomyces sp. HMH1 and HML1 possessing antagonism effect against tested phytopathogenic microbes. The secondary metabolites produced by these two actinomycete strains and their antiphytopathogenic fungi activity are investigated. The secondary metabolites from the fermentation extract of Streptomyces sp. HMH1 and HML1 are isolated and purified using various chromatography methods including silica gel column, reverse gel column and Sephadex LH-20 column chromatography. The structures of the isolated compounds are characterized by NMR, HR-ESI-MS spectroscopic data analyses and comparison with previously reported data. Three major compounds belonging to the family of actinomycin are purified from the solid fermentation extract of the sponge-derived actinobacterium Streptomyces sp. HMH1. They actinomycin D, actinomycin X2, and actinomycin Xoβ. A compound identified as K-252d belonging to the family of indolocarbazole alkaloid is isolated from the solid fermentation extract of another sponge-derived actinobacterium Streptomyces sp. HML1. The antiphytopathogenic fungi and bacteria activities of these compounds are evaluated against ten species of plant pathogenic fungi including Fusarium oxysporum FOC4, Lasiodiplodia theobromae, Phomopsis caricae-papayae Fetrak&Cif., Corynespora cassiicola, Phytophthora capsica, Pythium aphanidermatum (Edson) Fitzp, Corynespora sp., Fusarium graminearum, Verticillium dahlia, Pestalotiopsis microspo","PeriodicalId":35396,"journal":{"name":"Shenzhen Daxue Xuebao (Ligong Ban)/Journal of Shenzhen University Science and Engineering","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41597964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Pressure gradient prediction of gas-liquid two-phase pipe flow in horizontal gas wells 水平气井气液两相管流的压力梯度预测
Q4 Engineering Pub Date : 2022-09-01 DOI: 10.3724/sp.j.1249.2022.05567
Chengcheng Luo, N. Wu, Hua Wang, Yonghui Liu, Teng Zhang, Benqiang Wang, Pengbo Wu, J. Liu
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引用次数: 0
Application of machine learning algorithm in the prediction of fuel rod temperature performance 机器学习算法在燃料棒温度性能预测中的应用
Q4 Engineering Pub Date : 2022-09-01 DOI: 10.3724/sp.j.1249.2022.05515
Liang Hong, Xin Jin, Xiaohan Liu, X. Wei
Abstract: In order to predict the fuel rod temperature performance effectively, we establish a series of machine learning models based on k-nearest neighbor, decision tree and AdaBoost algorithms. The input parameters and calculation results of fuel rod performance analysis software JASMINE and data feature engineering are used as the training and test data for the machine learning models. The models are trained by the training data set which includes the characteristic parameters such as pellet and cladding type, axial height, local power, cladding corrosion thickness and core inlet temperature. After training, the models use the test data to predict the cladding outside surface temperature and pellet center temperature. The prediction results show that the model based on AdaBoost algorithm has the best prediction performances, and the mean square errors of cladding outside surface temperature and pellet center temperature are 0. 605 °C and 8. 347 °C, respectively, and the average absolute errors are 0. 273 °C and 3. 814 °C , respectively. Comparing the predicted values with the target values, the maximum deviation of Adaboost algorithm for the cladding outside surface temperature is 3 °C, and the most of the prediction deviation of the pellet center temperature is less than 10 °C, indicating that the model based on AdaBoost algorithm has the high prediction accuracy for the temperature performance of fuel rods.
摘要:为了有效地预测燃料棒的温度性能,我们建立了一系列基于k近邻、决策树和AdaBoost算法的机器学习模型。燃料棒性能分析软件JASMINE和数据特征工程的输入参数和计算结果被用作机器学习模型的训练和测试数据。模型通过训练数据集进行训练,训练数据集包括特征参数,如芯块和包层类型、轴向高度、局部功率、包层腐蚀厚度和堆芯入口温度。训练后,模型使用测试数据来预测包壳外表面温度和芯块中心温度。预测结果表明,基于AdaBoost算法的模型具有最好的预测性能,包壳外表面温度和芯块中心温度的均方误差为0。605°C和8。347°C,平均绝对误差为0。273°C和3。814°C。将预测值与目标值进行比较,Adaboost算法对包壳外表面温度的最大偏差为3°C,芯块中心温度的大部分预测偏差小于10°C,表明基于Adabost算法的模型对燃料棒的温度性能具有较高的预测精度。
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引用次数: 0
An algorithm for matching original experimental records based on improved CDC 基于改进CDC的原始实验记录匹配算法
Q4 Engineering Pub Date : 2022-09-01 DOI: 10.3724/sp.j.1249.2022.05509
Yi'na Cai, Xin Chen, Zhi-qiang Qin, Xin Wang, Xianyu Bao, Jinxue Peng, Yongqi Lin, Junlin Li
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引用次数: 0
Impact of trucks registered in other provinces on ETC differentiated charging in provincial expressway network 外省注册货车对省际高速公路网ETC差别化收费的影响
Q4 Engineering Pub Date : 2022-09-01 DOI: 10.3724/sp.j.1249.2022.05608
Sheng-yu Yan, Zhenyu Zhan, Yanhong Li, Junyi Zhang
Abstract: To evaluate the effect of policy on province-wide toll discount for electronic toll collection (ETC) trucks, and to clarify the influence of trucks registered in other provinces on the toll discount flowed back to the local enterprises, we use structured query language server (SQL Server) database technology to process the toll collection data on expressway network, and propose an algorithm of recovery rate for the explanatory variables of toll preference, and verify the feasibility of the algorithm is by a case study. The results show that the recovery rate of the study case is 43. 38% when there is an 85% discount on ETC truck toll in 2019, and 52. 77% of the 56. 62% toll discount outflowed from the case studied is generated by the trucks registered in other provinces according to a conservative estimate. Among them, the proportion of the toll discount of trucks registered in other provinces with 6 axles accounts for 77. 29%, which is the root of toll discount loss. Although the traffic number across the province is not
摘要:为了评估电子收费(ETC)卡车全省通行费优惠政策的效果,并阐明在外省注册的卡车对回流到当地企业的通行费优惠的影响,我们使用结构化查询语言服务器(SQL server)数据库技术来处理高速公路网上的收费数据,并针对收费偏好的解释变量提出了一种恢复率算法,并通过实例验证了该算法的可行性。结果表明,该研究病例的恢复率为43。2019年ETC卡车通行费有85%折扣时为38%,以及52。56。根据保守估计,所研究案例中62%的通行费折扣是由在其他省份注册的卡车产生的。其中,6轴外省注册货车通行费优惠比例占77。29%,这是通行费折扣损失的根源。尽管全省的交通量不是
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引用次数: 0
Machine learning based method for forecasting short-term passenger flow in urban rail stations 基于机器学习的城市轨道车站短期客流预测方法
Q4 Engineering Pub Date : 2022-09-01 DOI: 10.3724/sp.j.1249.2022.05593
Mingwei Hu, Xiaolong Shi, Wen Wu, Guoqing He
交通压力的有效途径之一.为提高轨道系统的运行效率,实现轨道交通智慧化运营,基于机器学习算法理 论,结合轨道交通车站的时间、空间及外部影响因素等客流特征,建立轻量的梯度提升机(light gradient boosting machine,LightGBM)、长短期记忆(long short-term memory,LSTM)及 LightGBM-LSTM融合模型的车 站短时客流预测模型,同时构建差分自回归移动平均(autoregressive integrated moving average,ARIMA)和极 限梯度提升(extreme gradient boosting,XGBoost)模型作为预测实验的对照模型.以中国杭州地铁自动售票系 统刷卡数据为例,选取了5种地铁车站(居住类型、工作类型、居住工作混合类型、购物类型及交通枢纽类 型)和3个准确性评价指标(平均绝对误差、均方根误差及平均绝对百分误差),量化评价不同模型的预测准
One of the effective ways to improve the operational efficiency of the rail system and achieve intelligent operation of rail transit, based on machine learning algorithm theory, combined with the passenger flow characteristics of rail transit stations such as time, space, and external influencing factors, a lightweight gradient boosting machine (LightGBM), long short term memory (LSTM), and LightGBM-LSTM fusion model for station short-term passenger flow prediction are established, Simultaneously constructing differential autoregressive integrated moving average (ARIMA) and extreme gradient boosting (XGBoost) models as control models for predictive experiments. Taking the swiping data of the Hangzhou subway ticketing system in China as an example, Five subway stations (residential type, work type, mixed residential and work type, shopping type, and transportation hub type) and three accuracy evaluation indicators (average absolute error, root mean square error, and average absolute percentage error) were selected to quantitatively evaluate the predictive accuracy of different models
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引用次数: 0
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Shenzhen Daxue Xuebao (Ligong Ban)/Journal of Shenzhen University Science and Engineering
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