Pub Date : 2015-03-31DOI: 10.2174/157339551101150417101550
A. Tuttolomondo, C. Maida, A. Pinto
{"title":"Inflammation and Inflammatory Cell Recruitment in Acute Cerebrovascular Diseases","authors":"A. Tuttolomondo, C. Maida, A. Pinto","doi":"10.2174/157339551101150417101550","DOIUrl":"https://doi.org/10.2174/157339551101150417101550","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":"11 1","pages":"24-32"},"PeriodicalIF":0.0,"publicationDate":"2015-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/157339551101150417101550","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68098569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-03-31DOI: 10.2174/1573395510666140626210842
A. Ferrante, F. Ciccia, G. Guggino, A. Giardina, G. Triolo
{"title":"Cell Immunity in Inflammatory Vasculitis","authors":"A. Ferrante, F. Ciccia, G. Guggino, A. Giardina, G. Triolo","doi":"10.2174/1573395510666140626210842","DOIUrl":"https://doi.org/10.2174/1573395510666140626210842","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":"11 1","pages":"3-11"},"PeriodicalIF":0.0,"publicationDate":"2015-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1573395510666140626210842","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68097795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-03-31DOI: 10.2174/157339551101150417102232
G. Porebski, L. Valeyrie‐Allanore, François Berrehar, S. Gouvello
{"title":"In Vitro Immunologic Tests in Severe Cutaneous Adverse Reactions (SCARs)","authors":"G. Porebski, L. Valeyrie‐Allanore, François Berrehar, S. Gouvello","doi":"10.2174/157339551101150417102232","DOIUrl":"https://doi.org/10.2174/157339551101150417102232","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":"11 1","pages":"33-42"},"PeriodicalIF":0.0,"publicationDate":"2015-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68098599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.2174/1573395511666150707181644
Gregory F Wu, Chelsea R Parker Harp, Kenneth S Shindler
Evidence for the tenuous regulation between the immune system and central nervous system (CNS) can be found with examples of interaction between these organ systems gone awry. Multiple sclerosis (MS) is the prototypical inflammatory disease of the CNS and is characterized by widely distributed inflammatory demyelinating plaques that can involve the brain, spinal cord and/or optic nerves. Optic neuritis (ON), inflammatory injury of the optic nerve that frequently occurs in patients with MS, has been the focus of intense study in part given the readily accessible nature of clinical outcome measures. Exploring the clinical and pathological features of ON in relation to other inflammatory demyelinating conditions of the CNS, namely MS and neuromyelitis optica, provides an opportunity to glean common and distinct mechanisms of disease. Emerging data from clinical studies along with various animal models involving ON implicate innate and adaptive immune responses directed at glial targets, including myelin oligodendrocyte glycoprotein and aquaporin 4. Resolution of inflammation in ON is commonly observed both clinically and experimentally, but persistent nerve injury is also one emerging hallmark of ON. One hypothesis seeking evaluation is that, in comparison to other sites targeted in MS, the optic nerve is a highly specialized target within the CNS predisposing to unique immunologic processes that generate ON. Overall, ON serves as a highly relevant entity for understanding the pathogenesis of other CNS demyelinating conditions, most notably MS.
{"title":"Optic Neuritis: A Model for the Immuno-pathogenesis of Central Nervous System Inflammatory Demyelinating Diseases.","authors":"Gregory F Wu, Chelsea R Parker Harp, Kenneth S Shindler","doi":"10.2174/1573395511666150707181644","DOIUrl":"https://doi.org/10.2174/1573395511666150707181644","url":null,"abstract":"<p><p>Evidence for the tenuous regulation between the immune system and central nervous system (CNS) can be found with examples of interaction between these organ systems gone awry. Multiple sclerosis (MS) is the prototypical inflammatory disease of the CNS and is characterized by widely distributed inflammatory demyelinating plaques that can involve the brain, spinal cord and/or optic nerves. Optic neuritis (ON), inflammatory injury of the optic nerve that frequently occurs in patients with MS, has been the focus of intense study in part given the readily accessible nature of clinical outcome measures. Exploring the clinical and pathological features of ON in relation to other inflammatory demyelinating conditions of the CNS, namely MS and neuromyelitis optica, provides an opportunity to glean common and distinct mechanisms of disease. Emerging data from clinical studies along with various animal models involving ON implicate innate and adaptive immune responses directed at glial targets, including myelin oligodendrocyte glycoprotein and aquaporin 4. Resolution of inflammation in ON is commonly observed both clinically and experimentally, but persistent nerve injury is also one emerging hallmark of ON. One hypothesis seeking evaluation is that, in comparison to other sites targeted in MS, the optic nerve is a highly specialized target within the CNS predisposing to unique immunologic processes that generate ON. Overall, ON serves as a highly relevant entity for understanding the pathogenesis of other CNS demyelinating conditions, most notably MS.</p>","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":"11 2","pages":"85-92"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1573395511666150707181644","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35791466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-12-04DOI: 10.2174/1573395511666141204224229
C. Saini, M. Tarique, Sudhir Kumar, D. N. Rao
{"title":"Role of FoxP3 + Treg Cells Mediating Immune Suppression in Leprosy","authors":"C. Saini, M. Tarique, Sudhir Kumar, D. N. Rao","doi":"10.2174/1573395511666141204224229","DOIUrl":"https://doi.org/10.2174/1573395511666141204224229","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":"11 1","pages":"66-72"},"PeriodicalIF":0.0,"publicationDate":"2014-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1573395511666141204224229","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68098645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-10-31DOI: 10.2174/1573395510666141023224934
Frank Wilkinson and Diana R. Cundell
{"title":"From Test Tube to Clinical Trial; Promising Herbs with NF-κB and COX- 2 Activity","authors":"Frank Wilkinson and Diana R. Cundell","doi":"10.2174/1573395510666141023224934","DOIUrl":"https://doi.org/10.2174/1573395510666141023224934","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":"10 1","pages":"82-98"},"PeriodicalIF":0.0,"publicationDate":"2014-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68097542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-10-31DOI: 10.2174/1573395510666141029233003
Diana R. Cundell and Frank Wilkinson
{"title":"Curcumin: Powerful Immunomodulator from Turmeric","authors":"Diana R. Cundell and Frank Wilkinson","doi":"10.2174/1573395510666141029233003","DOIUrl":"https://doi.org/10.2174/1573395510666141029233003","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":"40 1","pages":"122-132"},"PeriodicalIF":0.0,"publicationDate":"2014-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68097585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-10-31DOI: 10.2174/1573395510666141023000737
Anne H. Bower and Diana R. Cundell
{"title":"Immunomodulatory Activity of Astragalus, Ginseng and Echinacea: From Keith Block and Mark Mead to Today, Have We Moved On?","authors":"Anne H. Bower and Diana R. Cundell","doi":"10.2174/1573395510666141023000737","DOIUrl":"https://doi.org/10.2174/1573395510666141023000737","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":"10 1","pages":"99-112"},"PeriodicalIF":0.0,"publicationDate":"2014-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68097501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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