Pub Date : 2018-07-31DOI: 10.2174/1573395514666180904125809
Bianca Dorana de Oliveira Souza, B. F. Diaz, Gabriela Guidugli, L. S. Ferraz, M. K. Amarante, S. Rocha, P. Marinello, Milena Menegazzo Miranda Sapla, Francisco José de Abreu Oliveira, M. Watanabe
{"title":"Natural Killer Cells: Prospects in Cancer Immunotherapy","authors":"Bianca Dorana de Oliveira Souza, B. F. Diaz, Gabriela Guidugli, L. S. Ferraz, M. K. Amarante, S. Rocha, P. Marinello, Milena Menegazzo Miranda Sapla, Francisco José de Abreu Oliveira, M. Watanabe","doi":"10.2174/1573395514666180904125809","DOIUrl":"https://doi.org/10.2174/1573395514666180904125809","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1573395514666180904125809","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47762812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-03-31DOI: 10.2174/1573395514666180412154529
Mostafa A. Abdel-maksoud and Saleh AL-Quraishy
{"title":"Autoimmune Diseases and Infections: A Controversial Relationship","authors":"Mostafa A. Abdel-maksoud and Saleh AL-Quraishy","doi":"10.2174/1573395514666180412154529","DOIUrl":"https://doi.org/10.2174/1573395514666180412154529","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1573395514666180412154529","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48504375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-03-31DOI: 10.2174/1573395514666180309161144
S. Lara-Reyna, T. Scambler, J. Holbrook, H. Jarosz-Griffiths, D. Peckham, M. McDermott
Background: The Unfolded Protein Response (UPR) is a well conserved mechanism that mammalian cells use to cope with stress and infections. This mechanism is exquisitely regulated at several levels, including post-transcriptional modifications by microRNAs. These small non-coding RNAs are mainly involved in the degradation of mRNA, thereby blocking protein translation. The finely balanced interplay between the UPR and microRNAs is altered in several disorders, contributing to both disease aetiology and pathology. Methods: We review and explore alterations in the UPR and microRNAs in several inflammatory conditions, including bone, lung, and neurodegenerative diseases. We also evaluate the impact of these alterations on the disruption of cellular homeostasis and suggest possible therapeutic options to restore this balance. Results: Several components of the UPR, including IRE1, ATF6, and PERK, are clearly dysregulated in inflammatory bone, lung, and neurodegenerative diseases, contributing to the inflammatory process in these disorders. XBP1s, which is downstream of IRE1, is shown to be dysregulated in several diseases, and significantly contributes to the inflammatory process. MicroRNAs show unique dysregulated signatures in each individual tissue and disorder, suggesting that these small transcripts may regulate different pathways in a cell-dependent manner. Finally, there are functional connections between these dysregulated microRNAs and the UPR, which may underlie important pathological aspects of these disorders. Conclusion: It is evident that microRNAs regulate several components of the UPR and that these small non-coding RNAs, or other molecules that restore the UPR balance, may represent possible therapeutic options to normalise intracellular homeostasis.
{"title":"Regulation of the Unfolded Protein Response in Disease: Cellular Stress and microRNAs","authors":"S. Lara-Reyna, T. Scambler, J. Holbrook, H. Jarosz-Griffiths, D. Peckham, M. McDermott","doi":"10.2174/1573395514666180309161144","DOIUrl":"https://doi.org/10.2174/1573395514666180309161144","url":null,"abstract":"Background: The Unfolded Protein Response (UPR) is a well conserved mechanism that mammalian cells use to cope with stress and infections. This mechanism is exquisitely regulated at several levels, including post-transcriptional modifications by microRNAs. These small non-coding RNAs are mainly involved in the degradation of mRNA, thereby blocking protein translation. The finely balanced interplay between the UPR and microRNAs is altered in several disorders, contributing to both disease aetiology and pathology.\u0000\u0000\u0000\u0000Methods: We review and explore alterations in the UPR and microRNAs in several inflammatory conditions, including bone, lung, and neurodegenerative diseases. We also evaluate the impact of these alterations on the disruption of cellular homeostasis and suggest possible therapeutic options to restore this balance.\u0000\u0000\u0000\u0000Results: Several components of the UPR, including IRE1, ATF6, and PERK, are clearly dysregulated in inflammatory bone, lung, and neurodegenerative diseases, contributing to the inflammatory process in these disorders. XBP1s, which is downstream of IRE1, is shown to be dysregulated in several diseases, and significantly contributes to the inflammatory process. MicroRNAs show unique dysregulated signatures in each individual tissue and disorder, suggesting that these small transcripts may regulate different pathways in a cell-dependent manner. Finally, there are functional connections between these dysregulated microRNAs and the UPR, which may underlie important pathological aspects of these disorders.\u0000\u0000\u0000\u0000Conclusion: It is evident that microRNAs regulate several components of the UPR and that these small non-coding RNAs, or other molecules that restore the UPR balance, may represent possible therapeutic options to normalise intracellular homeostasis.","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1573395514666180309161144","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48196767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-03-31DOI: 10.2174/1573395514666180416155458
H. Shankar, P. Verma, D. N. Rao
Background: Recurrent Miscarriage (RM) is one of the most frustrating clinical situations wherein most of the cases, neither the engaged obstetrician nor suffering couples know the exact etiology and cause of the disease. About 10-15% of women with RM diagnosed with antiphospholipid syndrome (APS) are characterized by the marked presence of antiphospholipid antibodies (aPLa). There are several scientific reports available on the association between APS and RM; however, scanty data available about the beneficial role of coenzyme Q10 (CoQ10) in APS and APS mediated RM. In the present attempt, we tried to gather information to explain the possible associations between the role of CoQ10 in RM and APS. Methods: We collected peer-reviewed literature using keywords; antiphospholipid syndrome, CoQ10, endothelial dysfunction, oxidative stress and recurrent miscarriage in online electronic databases, such as Web of Science, Science Direct, Google Scholar, PubMed and Medline. The qualitative analysis of content was done by summarizing interventions and findings of included studies, on the basis of which a conceptual framework was prepared for this narrative review. Results: The beneficial role of CoQ10 in diverse pathological conditions has been summarized and the evidence suggests that CoQ10 being a potent antioxidant helps in the amelioration of free radicalmediated aPLa production, endothelial damage and mitochondrial dysfunction. The supplementation of CoQ10 overcomes the immune dysregulation in idiopathic RM and APS; thus could be a possible therapeutic adjunct in such diseases. Conclusion: Based on this review, further comprehensive studies may be conducted to illuminate the beneficial therapeutic effects of supplementing CoQ10 on possible modifiable pathways involved in the progression of RM and APS. A R T I C L E H I S T O R Y Received: December 29, 2017 Revised: April 06, 2018 Accepted: April 14, 2018 DOI: 10.2174/1573395514666180416155458
背景：复发性流产（RM）是最令人沮丧的临床情况之一，在大多数情况下，无论是产科医生还是痛苦的夫妇都不知道疾病的确切病因和原因。约10-15%的RM患者被诊断为抗磷脂综合征（APS），其特征是抗磷脂抗体（aPLa）的显著存在。关于APS和RM之间的联系，有几份科学报告；然而，关于辅酶Q10（CoQ10）在APS和APS介导的RM中的有益作用的可用数据很少。在目前的尝试中，我们试图收集信息来解释辅酶Q10在RM和APS中的作用之间的可能关联。方法：我们使用关键词收集同行评审的文献；在线电子数据库中的抗磷脂综合征、辅酶Q10、内皮功能障碍、氧化应激和复发性流产，如Web of Science、Science Direct、Google Scholar、PubMed和Medline。内容的定性分析是通过总结干预措施和纳入研究的结果来完成的，在此基础上为本次叙述性审查准备了一个概念框架。结果：总结了辅酶Q10在各种病理条件下的有益作用，有证据表明，辅酶Q10是一种强效抗氧化剂，有助于改善自由基介导的aPLa产生、内皮损伤和线粒体功能障碍。补充辅酶Q10克服了特发性RM和APS的免疫失调；因此可能是这类疾病的一种可能的辅助治疗手段。结论：在这篇综述的基础上，可以进行进一步的综合研究，以阐明补充辅酶Q10对参与RM和APS进展的可能的可改变途径的有益治疗作用。A R T I C L E H I S T O R Y收到时间：2017年12月29日修订日期：2018年4月6日接受时间：2018年04月14日DOI:10.2174/15739551466180416155458
{"title":"Coenzyme Q10: A Potential Adjunct for Treatment of Antiphospholipid Syndrome and Recurrent Miscarriage","authors":"H. Shankar, P. Verma, D. N. Rao","doi":"10.2174/1573395514666180416155458","DOIUrl":"https://doi.org/10.2174/1573395514666180416155458","url":null,"abstract":"Background: Recurrent Miscarriage (RM) is one of the most frustrating clinical situations wherein most of the cases, neither the engaged obstetrician nor suffering couples know the exact etiology and cause of the disease. About 10-15% of women with RM diagnosed with antiphospholipid syndrome (APS) are characterized by the marked presence of antiphospholipid antibodies (aPLa). There are several scientific reports available on the association between APS and RM; however, scanty data available about the beneficial role of coenzyme Q10 (CoQ10) in APS and APS mediated RM. In the present attempt, we tried to gather information to explain the possible associations between the role of CoQ10 in RM and APS. Methods: We collected peer-reviewed literature using keywords; antiphospholipid syndrome, CoQ10, endothelial dysfunction, oxidative stress and recurrent miscarriage in online electronic databases, such as Web of Science, Science Direct, Google Scholar, PubMed and Medline. The qualitative analysis of content was done by summarizing interventions and findings of included studies, on the basis of which a conceptual framework was prepared for this narrative review. Results: The beneficial role of CoQ10 in diverse pathological conditions has been summarized and the evidence suggests that CoQ10 being a potent antioxidant helps in the amelioration of free radicalmediated aPLa production, endothelial damage and mitochondrial dysfunction. The supplementation of CoQ10 overcomes the immune dysregulation in idiopathic RM and APS; thus could be a possible therapeutic adjunct in such diseases. Conclusion: Based on this review, further comprehensive studies may be conducted to illuminate the beneficial therapeutic effects of supplementing CoQ10 on possible modifiable pathways involved in the progression of RM and APS. A R T I C L E H I S T O R Y Received: December 29, 2017 Revised: April 06, 2018 Accepted: April 14, 2018 DOI: 10.2174/1573395514666180416155458","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1573395514666180416155458","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43295645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-03-31DOI: 10.2174/1573395514666180417143739
P. Verma, Alpana Sharma, H. Shankar, D. N. Rao
Background: Chikungunya infections are a major concern because of their persistent recurrence in the last few decades. Chikungunya virus (CHIKV) is a mosquito borne alpha virus that causes an acute febrile illness accompanied by body rashes, myalgia and polyarthralgia; which may persists for years. Chikungunya fever, affect millions of people in Africa, Asia, including the Indian subcontinent and lately in several regions of the Americas. No specific antivirals and vaccines are currently available to treat or prevent the disease. Methods: Understanding the mechanisms of host immune responses to CHIKV and the immunopathology of the disease is essential for the development of vaccines and diagnostics. Many studies have demonstrated the role of the immune response in the immunopathology of the disease and in the host’s incapability to clear the virus efficiently. In this review the excellence of the referenced papers were evaluated using standard tools. Results: Total seventy-four papers were included in the review. Majority of them were highlighted the importance of understanding the immunopathology of virus, contributing factor and control measures of the epidemics. Nineteen papers were provided the current occurrence and re-emergence of the disease. The diagnostic importance (sensitivity and specificity) of developed diagnostics for the early detection were also provided in eight papers. Conclusion: In the current review we highlighted the importance of conceptual mechanism of the host immune responses to CHIKV and the immunopathology of this alpha virus. The presented review provides an update on the infection, its vector, and the disease transmission, research development, and administration for avoidance of Chikungunya disease. A R T I C L E H I S T O R Y Received: August 16, 2017 Revised: January 12, 2018 Accepted: April 14, 2018 DOI: 10.2174/1573395514666180417143739
背景:基孔肯雅热感染是一个主要问题，因为它们在过去几十年中持续复发。基孔肯雅病毒(CHIKV)是一种蚊子传播的α病毒，可引起急性发热性疾病，并伴有皮疹、肌痛和多关节痛;这种情况可能会持续数年。基孔肯雅热影响到非洲、亚洲(包括印度次大陆)以及最近在美洲若干地区的数百万人。目前没有特定的抗病毒药物和疫苗可用于治疗或预防该疾病。方法:了解宿主对CHIKV的免疫反应机制和该病的免疫病理对疫苗和诊断的开发至关重要。许多研究已经证明了免疫反应在疾病的免疫病理和宿主无法有效清除病毒中的作用。在这篇综述中，我们使用标准工具对参考文献的优秀性进行评价。结果:共纳入74篇文献。强调了了解病毒免疫病理、致病因素和控制措施的重要性。提供了19篇关于该疾病目前发生和再次出现的论文。八篇论文也提供了诊断的重要性(敏感性和特异性)。结论:本综述强调了宿主对CHIKV免疫反应的概念机制和这种α病毒的免疫病理的重要性。本综述提供了基孔肯雅病感染、病媒和疾病传播、研究进展和预防基孔肯雅病管理的最新情况。A R T I C L E H I S T O R Y收稿日期:2017年08月16日修稿日期:2018年01月12日收稿日期:2018年04月14日DOI: 10.2174/1573395514666180417143739
{"title":"Chikungunya Infection and Immunity: An Overview","authors":"P. Verma, Alpana Sharma, H. Shankar, D. N. Rao","doi":"10.2174/1573395514666180417143739","DOIUrl":"https://doi.org/10.2174/1573395514666180417143739","url":null,"abstract":"Background: Chikungunya infections are a major concern because of their persistent recurrence in the last few decades. Chikungunya virus (CHIKV) is a mosquito borne alpha virus that causes an acute febrile illness accompanied by body rashes, myalgia and polyarthralgia; which may persists for years. Chikungunya fever, affect millions of people in Africa, Asia, including the Indian subcontinent and lately in several regions of the Americas. No specific antivirals and vaccines are currently available to treat or prevent the disease. Methods: Understanding the mechanisms of host immune responses to CHIKV and the immunopathology of the disease is essential for the development of vaccines and diagnostics. Many studies have demonstrated the role of the immune response in the immunopathology of the disease and in the host’s incapability to clear the virus efficiently. In this review the excellence of the referenced papers were evaluated using standard tools. Results: Total seventy-four papers were included in the review. Majority of them were highlighted the importance of understanding the immunopathology of virus, contributing factor and control measures of the epidemics. Nineteen papers were provided the current occurrence and re-emergence of the disease. The diagnostic importance (sensitivity and specificity) of developed diagnostics for the early detection were also provided in eight papers. Conclusion: In the current review we highlighted the importance of conceptual mechanism of the host immune responses to CHIKV and the immunopathology of this alpha virus. The presented review provides an update on the infection, its vector, and the disease transmission, research development, and administration for avoidance of Chikungunya disease. A R T I C L E H I S T O R Y Received: August 16, 2017 Revised: January 12, 2018 Accepted: April 14, 2018 DOI: 10.2174/1573395514666180417143739","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1573395514666180417143739","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44280739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-03-31DOI: 10.2174/1573395513666171031162100
R. Rezaei, S. Aslani, M. Marashi, F. Rezaei, E. Sharif-Paghaleh
Background: Vitamin D has mainly been described in the literature beyond its skeletal functions, including an influence on the immune responses against infections. Observational and interventional studies have represented evidence that Vitamin D deficiency may cause increased risk of seasonal influenza and pulmonary tract infection. Methods: A structured search of EMBASE, Medline, and Web of Science databases was fulfilled to extract all eligible articles published prior to September 2017. Results: In this review, our goal is to define the possible mechanisms that link influenza-mediated immune responses to Vitamin D. Herein, we first briefly describe the role of Vitamin D in the immune responses and then elucidate three immunological processes that connect Vitamin D to influenza infection. Finally, we describe randomized controlled trials and observational studies exploring the effect of Vitamin D supplementation on seasonal influenza infections and vaccinations. Conclusion: Our literature review suggests that treatment of influenza-infected individuals with Vitamin D supplements or cathelicidin-derived agents may provide appreciable protection against natural influenza infection. Moreover, Vitamin D given at appropriate doses may facilitate protection against seasonal flu. A R T I C L E H I S T O R Y Received: May 06, 2017 Revised: June 29, 2017 Accepted: October 12, 2017 DOI: 10.2174/1573395513666171031162100
背景:文献中对维生素D的描述主要超越了其骨骼功能，包括对抗感染免疫反应的影响。观察性和干预性研究表明，维生素D缺乏可能导致季节性流感和肺部感染的风险增加。方法:对EMBASE、Medline和Web of Science数据库进行结构化检索，提取2017年9月之前发表的所有符合条件的文章。结果:在这篇综述中，我们的目标是确定将流感介导的免疫反应与维生素D联系起来的可能机制。在这里，我们首先简要描述了维生素D在免疫反应中的作用，然后阐明了将维生素D与流感感染联系起来的三个免疫过程。最后，我们描述了探索补充维生素D对季节性流感感染和疫苗接种影响的随机对照试验和观察性研究。结论:我们的文献综述表明，用维生素D补充剂或抗菌肽衍生药物治疗流感感染个体可能提供明显的预防自然流感感染的保护。此外，适当剂量的维生素D可能有助于预防季节性流感。A R T I C L E H I S T O R Y收稿日期:2017年05月06日修稿日期:2017年06月29日收稿日期:2017年10月12日DOI: 10.2174/1573395513666171031162100
{"title":"Immunomodulatory Effects of Vitamin D in Influenza Infection","authors":"R. Rezaei, S. Aslani, M. Marashi, F. Rezaei, E. Sharif-Paghaleh","doi":"10.2174/1573395513666171031162100","DOIUrl":"https://doi.org/10.2174/1573395513666171031162100","url":null,"abstract":"Background: Vitamin D has mainly been described in the literature beyond its skeletal functions, including an influence on the immune responses against infections. Observational and interventional studies have represented evidence that Vitamin D deficiency may cause increased risk of seasonal influenza and pulmonary tract infection. Methods: A structured search of EMBASE, Medline, and Web of Science databases was fulfilled to extract all eligible articles published prior to September 2017. Results: In this review, our goal is to define the possible mechanisms that link influenza-mediated immune responses to Vitamin D. Herein, we first briefly describe the role of Vitamin D in the immune responses and then elucidate three immunological processes that connect Vitamin D to influenza infection. Finally, we describe randomized controlled trials and observational studies exploring the effect of Vitamin D supplementation on seasonal influenza infections and vaccinations. Conclusion: Our literature review suggests that treatment of influenza-infected individuals with Vitamin D supplements or cathelicidin-derived agents may provide appreciable protection against natural influenza infection. Moreover, Vitamin D given at appropriate doses may facilitate protection against seasonal flu. A R T I C L E H I S T O R Y Received: May 06, 2017 Revised: June 29, 2017 Accepted: October 12, 2017 DOI: 10.2174/1573395513666171031162100","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1573395513666171031162100","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42037353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-03-31DOI: 10.2174/1573395514666180118103149
D. Angeletti, G. Iannella, A. Ciofalo, M. Re, R. Plateroti, P. Plateroti, B. Pasquariello, A. Manno, D. Didona, G. Magliulo
{"title":"Otorhinolaryngological Manifestations in Sjogren Syndrome","authors":"D. Angeletti, G. Iannella, A. Ciofalo, M. Re, R. Plateroti, P. Plateroti, B. Pasquariello, A. Manno, D. Didona, G. Magliulo","doi":"10.2174/1573395514666180118103149","DOIUrl":"https://doi.org/10.2174/1573395514666180118103149","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1573395514666180118103149","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42779655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-12DOI: 10.2174/1573395513666170502130828
A. Tuttolomondo, Anna Cirrincione, Valerio Vassallo, M. Daidone, A. Pinto
{"title":"Endothelial Function and Pathogenesis of Endothelial Dysfunction","authors":"A. Tuttolomondo, Anna Cirrincione, Valerio Vassallo, M. Daidone, A. Pinto","doi":"10.2174/1573395513666170502130828","DOIUrl":"https://doi.org/10.2174/1573395513666170502130828","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":"13 1","pages":"115-131"},"PeriodicalIF":0.0,"publicationDate":"2018-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44325963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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