Pub Date : 2018-01-12DOI: 10.2174/157339551302180112103024
C. A. Guzmán
Dr. Farlow is Professor of Neurology and Vice-Chairman of Research in the Department of Neurology at the Indiana University School of Medicine in Indianapolis. He is also Associate Co-Director of the Indiana Alzheimer’s Disease Center in Indianapolis. Dr. Farlow received his medical degree from Indiana University School of Medicine and completed an internship in medicine and residency in neurology at the Indiana University Hospitals. Dr. Farlow is a member of many professional associations including the American Academy of Neurology, the American Neurological Association, and the American Geriatrics Society. He is also a founding member in both the American Society of Experimental Neurotherapeutics and the International Society for CNS Clinical Trials and Methodology. Dr. Farlow has lectured on the topics of aging, dementia, and Alzheimer’s disease at more than 300 meetings, conferences, and hospitals/medical schools throughout the world. He is a reviewer for numerous scientific journals and on the editorial boards of MedLink and Current Alzheimer Research. A prolific author, Dr. Farlow has presented more than 400 abstracts at professional meetings and has authored or co-authored more than 400 articles published in peer-reviewed journals such as Lancet Neurology, the Annals of Family Medicine, and the Journal of the American Geriatrics Society. Dr. Farlow’s research focuses on clinical trials of investigational drugs for the treatment of Alzheimer’s disease and related dementias being the lead investigator for several major studies including; tacrine, donepezil, rivastigmine and interests in trial design and safety. Dr. Farlow also has clinically characterized and helped determine genetic linkage for several familial dementias including the second mutation associated with autosomal dominantly inherited Alzheimer’s disease, GerstmannStraussler-Scheinker disease, and Multi Systems Tauopathy with Dementia.
{"title":"Meet Our Associate Editor","authors":"C. A. Guzmán","doi":"10.2174/157339551302180112103024","DOIUrl":"https://doi.org/10.2174/157339551302180112103024","url":null,"abstract":"Dr. Farlow is Professor of Neurology and Vice-Chairman of Research in the Department of Neurology at the Indiana University School of Medicine in Indianapolis. He is also Associate Co-Director of the Indiana Alzheimer’s Disease Center in Indianapolis. Dr. Farlow received his medical degree from Indiana University School of Medicine and completed an internship in medicine and residency in neurology at the Indiana University Hospitals. Dr. Farlow is a member of many professional associations including the American Academy of Neurology, the American Neurological Association, and the American Geriatrics Society. He is also a founding member in both the American Society of Experimental Neurotherapeutics and the International Society for CNS Clinical Trials and Methodology. Dr. Farlow has lectured on the topics of aging, dementia, and Alzheimer’s disease at more than 300 meetings, conferences, and hospitals/medical schools throughout the world. He is a reviewer for numerous scientific journals and on the editorial boards of MedLink and Current Alzheimer Research. A prolific author, Dr. Farlow has presented more than 400 abstracts at professional meetings and has authored or co-authored more than 400 articles published in peer-reviewed journals such as Lancet Neurology, the Annals of Family Medicine, and the Journal of the American Geriatrics Society. Dr. Farlow’s research focuses on clinical trials of investigational drugs for the treatment of Alzheimer’s disease and related dementias being the lead investigator for several major studies including; tacrine, donepezil, rivastigmine and interests in trial design and safety. Dr. Farlow also has clinically characterized and helped determine genetic linkage for several familial dementias including the second mutation associated with autosomal dominantly inherited Alzheimer’s disease, GerstmannStraussler-Scheinker disease, and Multi Systems Tauopathy with Dementia.","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":"13 1","pages":"99-99"},"PeriodicalIF":0.0,"publicationDate":"2018-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/157339551302180112103024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48674674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-12DOI: 10.2174/1573395513666171010142039
O. Guliy, V. Bunin, V. I. Korzhenevich, O. Ignatov
{"title":"Electro-Optical Assays for Immunoindication of Microbial Cells","authors":"O. Guliy, V. Bunin, V. I. Korzhenevich, O. Ignatov","doi":"10.2174/1573395513666171010142039","DOIUrl":"https://doi.org/10.2174/1573395513666171010142039","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":"13 1","pages":"153-162"},"PeriodicalIF":0.0,"publicationDate":"2018-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48016136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-12DOI: 10.2174/1573395513666170703151927
Bing He, Y. Chao, E. Tan, P. Li
{"title":"The Application of Aptasensors for the Aging Diseases Diagnosis","authors":"Bing He, Y. Chao, E. Tan, P. Li","doi":"10.2174/1573395513666170703151927","DOIUrl":"https://doi.org/10.2174/1573395513666170703151927","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":"13 1","pages":"144-152"},"PeriodicalIF":0.0,"publicationDate":"2018-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45233341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-12DOI: 10.2174/1573395513666170707145008
M. Ejtehadifar, S. Zahedi, G. Mosayebi, Ghasem Ghalamfarsa, A. Pishdadian, A. Ghazavi, M. Ebrahimi, A. Ganji
Abstract: Background: Autoimmune diseases, with emerging clinical concerns, are caused by imbalances in immune system functions. Cytokines are critical components of the immune system produced by various immune and non-immune cells. Objective: We will review the newly-introduced cytokine known as interleukin-27 (IL-27), which has both pro- and anti- inflammatory roles in immunity. Methods: Literature review of the field of immunology and cytokines in autoimmune diseases. Results: IL-27 alters the balance between the different types of T helper (Th) cells through reduction or promotion of their responses to autoimmune diseases including multiple sclerosis, ulcerative colitis, inflammatory bowel disease, rheumatoid arthritis, psoriasis, autoimmune diabetes, systemic lupus erythematosus, Sjogren's syndrome, Behcet’s disease, and autoimmune aplastic anemia. Conclusions: The functions of IL-27 are currently unclear because it appears to affect different cells, cytokines, and signaling pathways differently. Further investigations are needed to clarify the role of IL-27 in autoimmune diseases. Hence, this article reviewed the multiple roles of IL-27 in autoimmune diseases and describe the influence of IL-27 on the immune system.
{"title":"IL-27: Friend or Foe in the Autoimmune Diseases","authors":"M. Ejtehadifar, S. Zahedi, G. Mosayebi, Ghasem Ghalamfarsa, A. Pishdadian, A. Ghazavi, M. Ebrahimi, A. Ganji","doi":"10.2174/1573395513666170707145008","DOIUrl":"https://doi.org/10.2174/1573395513666170707145008","url":null,"abstract":"Abstract: \u0000 \u0000Background: Autoimmune diseases, with emerging clinical concerns, are caused by imbalances in immune system functions. Cytokines are critical components of the immune system produced by various immune and non-immune cells. Objective: We will review the newly-introduced cytokine known as interleukin-27 (IL-27), which has both pro- and anti- inflammatory roles in immunity. Methods: Literature review of the field of immunology and cytokines in autoimmune diseases. Results: IL-27 alters the balance between the different types of T helper (Th) cells through reduction or promotion of their responses to autoimmune diseases including multiple sclerosis, ulcerative colitis, inflammatory bowel disease, rheumatoid arthritis, psoriasis, autoimmune diabetes, systemic lupus erythematosus, Sjogren's syndrome, Behcet’s disease, and autoimmune aplastic anemia. Conclusions: The functions of IL-27 are currently unclear because it appears to affect different cells, cytokines, and signaling pathways differently. Further investigations are needed to clarify the role of IL-27 in autoimmune diseases. Hence, this article reviewed the multiple roles of IL-27 in autoimmune diseases and describe the influence of IL-27 on the immune system.","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":"13 1","pages":"163-170"},"PeriodicalIF":0.0,"publicationDate":"2018-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41367516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-01-12DOI: 10.2174/1573395513666171018145552
S. Thokchom, K. Gulati, Tarun Thakur, N. Rai, A. Ray
{"title":"Dendritic Cells and Immunomodulation: Role in Health and Disease","authors":"S. Thokchom, K. Gulati, Tarun Thakur, N. Rai, A. Ray","doi":"10.2174/1573395513666171018145552","DOIUrl":"https://doi.org/10.2174/1573395513666171018145552","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":"13 1","pages":"132-143"},"PeriodicalIF":0.0,"publicationDate":"2018-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43784676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-26DOI: 10.2174/1573395514666171226154300
Ada Paloma Soto-Brambila, G. Ortiz, Paloma Rivero-Moragrega, A. L. Briones-Torres, L. González-Ortiz, F. Pacheco-Moisés
{"title":"Relapsing Remitting Multiple Sclerosis and its Relationship with the Immune System and Oxidative Stress","authors":"Ada Paloma Soto-Brambila, G. Ortiz, Paloma Rivero-Moragrega, A. L. Briones-Torres, L. González-Ortiz, F. Pacheco-Moisés","doi":"10.2174/1573395514666171226154300","DOIUrl":"https://doi.org/10.2174/1573395514666171226154300","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1573395514666171226154300","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46979341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-31DOI: 10.2174/1573395513666170316110147
Marek A. Budzyński and Lea Sistonen
{"title":"Versatile Functions of Heat Shock Factors: It is Not All About Stress","authors":"Marek A. Budzyński and Lea Sistonen","doi":"10.2174/1573395513666170316110147","DOIUrl":"https://doi.org/10.2174/1573395513666170316110147","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":"13 1","pages":"4-18"},"PeriodicalIF":0.0,"publicationDate":"2017-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46329160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-03-31DOI: 10.2174/1573395513666170606121625
C. Habich, H. Sell, V. Burkart
{"title":"Regulatory Role of Heat Shock Proteins in the Pathogenesis of Type 1 and Type 2 Diabetes","authors":"C. Habich, H. Sell, V. Burkart","doi":"10.2174/1573395513666170606121625","DOIUrl":"https://doi.org/10.2174/1573395513666170606121625","url":null,"abstract":"","PeriodicalId":35403,"journal":{"name":"Current Immunology Reviews","volume":"13 1","pages":"82-90"},"PeriodicalIF":0.0,"publicationDate":"2017-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43488510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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