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Prevalence of Psychiatric Disorders among Patients with Granulomatosis with Polyangiitis (Wegener's) and the Predictive Role of Personality Traits. 韦格纳氏肉芽肿伴多血管炎(韦格纳氏病)患者的精神障碍患病率及人格特质的预测作用。
Q2 Medicine Pub Date : 2024-01-29 eCollection Date: 2024-01-01 DOI: 10.2174/0117450179276345240117043037
Nazanin Mousavi, Aghil Molaei, Samira Alesaeidi, Nader Eftekhari Seas, Mohammad Effatpanah

Background: Wegener's disease is an autoimmune condition affecting the respiratory tract and kidneys. Mental health assessment is crucial due to the impact of psychological disorders on the immune system. Despite this, there is limited community-based research on psychiatric disorders and personality traits among patients with Wegener's disease.

Objective: This study aimed to investigate the prevalence of psychiatric disorders and examine the predictive role of personality traits among patients with Wegener's disease.

Methods: A total of 100 patients met the inclusion and exclusion criteria, and all of them were selected to participate in the study. Out of them, 75 individuals completed the questionnaires. The instruments included the SCL-90 questionnaire and the NEO Big Five personality traits. The data were analysed using Stata software, and the prevalence of psychiatric disorders in different patient groups was determined using the chi-square method. The predictive role of personality traits in mental disorders was examined using multivariate regression.

Results: The results revealed that paranoia (53.3%) and depression (44%) had the highest prevalence in terms of psychiatric disorders, while psychosis (17.3%) and hostility (25.33%) had the lowest prevalence. Additionally, the findings demonstrated a positive correlation between most psychiatric disorders and the neuroticism personality trait.

Conclusion: Given the influence of mental disorders on the immune system in Wegener's disease, it is essential to provide psychological care for these patients.

背景:韦格纳病是一种影响呼吸道和肾脏的自身免疫性疾病:韦格纳氏病是一种影响呼吸道和肾脏的自身免疫性疾病。由于心理障碍会影响免疫系统,因此心理健康评估至关重要。尽管如此,以社区为基础对韦格纳病患者的精神障碍和人格特征进行的研究却十分有限:本研究旨在调查韦格纳病患者中精神障碍的患病率,并研究人格特质的预测作用:共有 100 名患者符合纳入和排除标准,并被全部选中参与研究。其中 75 人完成了问卷调查。调查工具包括 SCL-90 问卷和 NEO 五大人格特质。研究使用 Stata 软件对数据进行了分析,并使用卡方方法确定了不同患者群体的精神病患病率。采用多元回归法研究了人格特质对精神障碍的预测作用:结果显示,偏执狂(53.3%)和抑郁症(44%)在精神障碍中的发病率最高,而精神病(17.3%)和敌意(25.33%)的发病率最低。此外,研究结果表明,大多数精神障碍与神经质人格特质之间存在正相关:结论:鉴于精神障碍对韦格纳氏病患者免疫系统的影响,为这些患者提供心理护理至关重要。
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引用次数: 0
Illness Anxiety Disorder and Distress among Female Medical and Nursing Students. 医科和护理专业女学生的疾病焦虑症和压力。
Q2 Medicine Pub Date : 2023-11-20 eCollection Date: 2023-01-01 DOI: 10.2174/0117450179277976231115070100
Sana Hawamdeh, Fatchima L Moussa, Sami Al-Rawashdeh, Sajidah Al Hawamdih, Mahaman L Moussa

Objective: This study aims to compare the prevalence of illness anxiety disorder (IAD) and distress between medical and nursing students and examine their associations with students' characteristics.

Methods: Cross-sectional data were collected using the Short Health Anxiety Inventory (SHAI, for measuring IAD) and the Medical Students' Disease (MSD) Perception and Distress Scales.

Results: Two hundred and sixteen Medical students and 250 Nursing students were recruited from a public female university in Saudi Arabia. Their mean age was 21.27 years. The findings showed that the overall prevalence of IAD (SHAI scores ≥18) among the total sample was 38.8%, with a significantly lower prevalence in medical students compared to the prevalence in nursing students (57.2% vs 17.6%, respectively, X2=45.26, p<.001). Nursing students had significantly higher SHAI scores and lower MSD Perception scores than medical college students, but there were no significant differences among them in the MSD Distress scale. Significant differences in the main study variables scores were reported among nursing students but not among medical students, with the fourth-year level nursing students having higher SHAI and lower MSD Perception and perception scores than other nursing students.

Conclusion: The highlights that medical and nursing students are susceptible to developing anxiety-related disorders and distress that may have negative impacts on their academic achievements and future careers. Both nursing and medical faculty should help in identifying strategies to support the students' mental health and well-being.

研究目的本研究旨在比较医科学生和护理专业学生的疾病焦虑症(IAD)和痛苦的发生率,并研究它们与学生特征的关系:方法:采用简易健康焦虑量表(SHAI,用于测量 IAD)和医学生疾病(MSD)感知与痛苦量表收集横断面数据:从沙特阿拉伯一所公立女子大学招募了 216 名医科学生和 250 名护理专业学生。他们的平均年龄为 21.27 岁。调查结果显示,在所有样本中,IAD(SHAI 评分≥18 分)的总体患病率为 38.8%,与护理专业学生相比,医科学生的患病率明显较低(分别为 57.2% vs 17.6%,X2=45.26,pConclusion):研究强调,医科和护理专业的学生很容易患上与焦虑相关的疾病和焦虑症,这可能会对他们的学业成绩和未来职业生涯产生负面影响。护理和医学专业的教师都应帮助确定支持学生心理健康和幸福的策略。
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引用次数: 0
"It has to be better, otherwise we will get stuck." A Review of Novel Directions for Mental Health Reform and Introducing Pilot Work in the Netherlands. "必须做得更好,否则我们就会陷入困境"。精神卫生改革的新方向与荷兰试点工作介绍》。
Q2 Medicine Pub Date : 2023-11-17 eCollection Date: 2023-01-01 DOI: 10.2174/0117450179271206231114064736
Jim van Os, Floortje Scheepers, Michael Milo, Gijs Ockeloen, Sinan Guloksuz, Philippe Delespaul

Background: The current state of mental health care in the Netherlands faces challenges such as fragmentation, inequality, inaccessibility, and a narrow specialist focus on individual diagnosis and symptom reduction.

Methods: A review suggests that in order to address these challenges, an integrated public health approach to mental health care that encompasses the broader social, cultural, and existential context of mental distress is required.

Results: A Mental Health Ecosystem social trial seeks to pilot such an approach in the Netherlands, focusing on empowering patients and promoting collaboration among various healthcare providers, social care organizations, and peer-support community organizations, working together in a regional ecosystem of care and committed to a set of shared values. In the ecosystem, mental health problems are examined through the prism of mental variation in context whilst scaling up the capacity of group-based treatment and introducing a flexible and modular approach of (2nd order) treatment by specialists across the ecosystem. The approach is to empower naturally available resources in the community beyond professionally run care facilities. Digital platforms such as psychosenet.nl and proud2bme.nl, which complement traditional mental health care services and enhance public mental health, will be expanded. The capacity of recovery colleges will be increased, forming a national network covering the entire country. GEM will be evaluated using a population-based approach, encompassing a broad range of small-area indicators related to mental health care consumption, social predictors, and clinical outcomes. The success of GEM relies heavily on bottom-up development backed by stakeholder involvement, including insurers and policy-making institutions, and cocreation.

Conclusion: By embracing a social trial and leveraging digital platforms, the Dutch mental health care system can overcome challenges and provide more equitable, accessible, and high-quality care to individuals.

背景:荷兰目前的精神卫生保健面临着一些挑战,如分散、不平等、难以获得,以及专家狭隘地专注于个人诊断和症状缓解:方法:一项研究表明,为了应对这些挑战,需要对精神卫生保健采取一种综合的公共卫生方法,这种方法应涵盖更广泛的社会、文化和精神痛苦的存在背景:心理健康生态系统社会试验试图在荷兰试行这种方法,重点是增强患者的能力,促进各种医疗服务提供者、社会医疗机构和同伴支持社区组织之间的合作,在一个区域医疗生态系统中共同努力,并致力于实现一系列共同的价值观。在这个生态系统中,心理健康问题将从心理变异的角度加以审视,同时扩大以小组为基础的治疗能力,并在整个生态系统中引入由专家提供(二阶)治疗的灵活和模块化方法。这种方法的目的是在专业护理机构之外,增强社区自然可用资源的能力。诸如 psychosenet.nl 和 proud2bme.nl 等数字平台将得到扩展,这些平台是对传统心理保健服务的补充,并能提高公众的心理健康水平。将提高康复学院的能力,形成一个覆盖全国的国家网络。将采用以人口为基础的方法对 GEM 进行评估,评估内容包括与心理保健消费、社会预测因素和临床结果相关的一系列小范围指标。GEM 的成功在很大程度上依赖于自下而上的发展,并以利益相关者(包括保险公司和决策机构)的参与和共同创造为后盾:通过接受社会试验和利用数字平台,荷兰心理健康医疗系统可以克服挑战,为个人提供更公平、更便捷、更优质的医疗服务。
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引用次数: 0
Self-compassion, Positive and Negative Affect and Social Avoidance among Adolescence: Mediating Role of Mindfulness. 青少年的自我同情、积极和消极情绪以及社交回避:正念的中介作用
Q2 Medicine Pub Date : 2023-11-17 eCollection Date: 2023-01-01 DOI: 10.2174/0117450179268979231114045116
M S Sujamani, Barani Kanth

Objective: Mindfulness is an attribute of consciousness to manage social fear avoidance and promote well-being. Social anxiety is a common psychological experience noted among the general population. Social anxiety develops during adolescence and is prevalent among college students. This study investigates the factors contributing to social anxiety - fear and avoidance of social situations of female first-year undergraduates.

Methods: The study used a survey research design. A sample of 821 first-year female undergraduate students aged between 17 and 19. Data were collected using the Liebowitz Social anxiety scale, the Five-Facet mindfulness questionnaire, A short form of the Self-compassion scale, and the Positive and Negative affect scale.

Results: Mindfulness weakens social fear and reduces the tendency to avoid social situations. Mindfulness effectively mediates the impact of self-compassion's positive affect and negative effects on social fear. Mindfulness and social fear jointly mediate the impact of self-compassion, positive affect, and negative affect on social avoidance.

Conclusion: Mindfulness is the awareness and acceptance of the feelings, thoughts and sensations attached to self and its possible reciprocity with social surroundings to mitigate fear-self-compassion and positive emotional affect augment, and negative emotional affect attenuate mindfulness. Results analysis highlights the mediation of mindfulness on social anxiety, self-compassion, positive affect, and negative affect.

目的:正念是一种管理社交恐惧回避和促进身心健康的意识属性。社交焦虑是普通人常见的一种心理体验。社交焦虑在青春期开始形成,在大学生中十分普遍。本研究调查了导致大一女大学生社交焦虑--害怕和回避社交场合--的因素:本研究采用调查研究设计。抽样调查了 821 名年龄在 17 至 19 岁之间的一年级女大学生。使用利伯维茨社交焦虑量表、五方面正念问卷、自我同情量表简表以及积极和消极情绪量表收集数据:结果:正念能减弱社交恐惧,减少回避社交情境的倾向。正念有效地调节了自我同情对社交恐惧的积极影响和消极影响。正念和社交恐惧共同调节了自我同情、积极情感和消极情感对社交回避的影响:正念是对附着于自身的情感、想法和感觉及其与社会环境之间可能存在的互惠关系的意识和接受,以减轻恐惧--自我同情和积极情绪影响增强正念,而消极情绪影响减弱正念。结果分析强调了正念对社交焦虑、自我同情、积极情绪和消极情绪的调节作用。
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引用次数: 0
First Onset in Adulthood of Mental Disorders: Exposure to War vs. Non-war Childhood Adversities: A National Study. 成年后首次出现精神障碍:暴露于战争与非战争童年逆境:一项全国性研究。
Q2 Medicine Pub Date : 2023-11-07 eCollection Date: 2023-01-01 DOI: 10.2174/0117450179216651231106072824
Elie Karam, Josleen Al Barathie, Dahlia Saab, Aimee Nasser Karam, John Fayyad

Background: There is evidence that some childhood trauma increases the risk of the first onset of mental disorders and for the first time into adulthood. There are no studies that assessed whether exposure to war has this delayed long-term effect.

Objectives: To fill this gap by investigating the comparative roles of war and non-war trauma on the first onset of adulthood mood and anxiety disorders.

Methods: A nationally representative sample of 2,857 Lebanese was assessed using the World Health Organization Composite International Diagnostic Interview 3.0. with the onset of exposure to trauma and of first onset of mood and anxiety disorders.

Results: Non-war childhood traumata especially those belonging to family malfunctioning continue to exert their effect for the first time well beyond their occurrence as they were the most universal predictors for adult onset of both mood and anxiety disorders. War trauma during childhood predicted mood anxiety and mood (anxiety only in males) only below age 18 y. war childhood trauma predicts the first onset of mood and anxiety disorders before age 18 y in females, but only anxiety in males.

Conclusion: Childhood traumata are not equal in predicting the first onset of mood and anxiety disorders into adulthood. Family malfunctioning looks to carry the longest such risk and war more of shorter immediate effects. This might change though with re-exposure to war in adulthood which might unravel dormant vulnerability.

背景:有证据表明,某些童年创伤会增加首次患上精神疾病的风险,并在成年后首次出现。目前还没有研究评估战争创伤是否会产生这种延迟的长期影响:目的:通过研究战争创伤和非战争创伤对成年后首次出现情绪和焦虑障碍的比较作用来填补这一空白:方法:使用世界卫生组织国际综合诊断访谈 3.0,对具有全国代表性的 2,857 名黎巴嫩人进行了评估:结果:非战争时期的童年创伤,尤其是属于家庭功能失调的创伤,在其发生后仍会首次产生影响,因为它们是成年后情绪和焦虑症发病的最普遍的预测因素。童年时期的战争创伤只预测 18 岁以下的情绪焦虑和情绪(焦虑只发生在男性身上),童年时期的战争创伤预测女性在 18 岁之前首次出现情绪和焦虑障碍,但只预测男性的焦虑:结论:在预测成年后首次出现情绪和焦虑障碍方面,童年创伤的作用并不相同。家庭功能失调似乎具有最长的此类风险,而战争更多的是短期的直接影响。不过,随着成年后再次接触战争,这种情况可能会发生变化,因为战争可能会揭开沉睡的脆弱性。
{"title":"First Onset in Adulthood of Mental Disorders: Exposure to War <i>vs</i>. Non-war Childhood Adversities: A National Study.","authors":"Elie Karam, Josleen Al Barathie, Dahlia Saab, Aimee Nasser Karam, John Fayyad","doi":"10.2174/0117450179216651231106072824","DOIUrl":"https://doi.org/10.2174/0117450179216651231106072824","url":null,"abstract":"<p><strong>Background: </strong>There is evidence that some childhood trauma increases the risk of the first onset of mental disorders and for the first time into adulthood. There are no studies that assessed whether exposure to war has this delayed long-term effect.</p><p><strong>Objectives: </strong>To fill this gap by investigating the comparative roles of war and non-war trauma on the first onset of adulthood mood and anxiety disorders.</p><p><strong>Methods: </strong>A nationally representative sample of 2,857 Lebanese was assessed using the World Health Organization Composite International Diagnostic Interview 3.0. with the onset of exposure to trauma and of first onset of mood and anxiety disorders.</p><p><strong>Results: </strong>Non-war childhood traumata especially those belonging to family malfunctioning continue to exert their effect for the first time well beyond their occurrence as they were the most universal predictors for adult onset of both mood and anxiety disorders. War trauma during childhood predicted mood anxiety and mood (anxiety only in males) only below age 18 y. war childhood trauma predicts the first onset of mood and anxiety disorders before age 18 y in females, but only anxiety in males.</p><p><strong>Conclusion: </strong>Childhood traumata are not equal in predicting the first onset of mood and anxiety disorders into adulthood. Family malfunctioning looks to carry the longest such risk and war more of shorter immediate effects. This might change though with re-exposure to war in adulthood which might unravel dormant vulnerability.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"19 ","pages":"e17450179216651"},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11037514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140855374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
QbTest for Monitoring Medication Treatment Response in ADHD: A Systematic Review. 用于监测多动症药物治疗反应的 QbTest:系统回顾
Q2 Medicine Pub Date : 2023-11-01 eCollection Date: 2023-01-01 DOI: 10.2174/0117450179276630231030093814
Urban Gustafsson, Mikkel Hansen

Introduction: Attention deficit hyperactivity disorder (ADHD) is considered one of the most common neurodevelopmental disorders in childhood and adolescence. Pharmacological treatment plays an important part in the therapy of the disorder and verifying the effectiveness of ADHD medication is essential throughout the course of treatment. QbTest is a computerized test, for which intended use is to provide healthcare professionals with objective measurements of hyperactivity, impulsivity, and inattention to aid in the clinical assessment of ADHD and the evaluation of treatment interventions.

Methods: A systematic review of relevant articles was conducted for which QbTest was used for monitoring medication treatment response in ADHD. Literature published between 2004 and 2023 was appraised.

Results: A total of 15 studies were included in the review. Thirteen articles involved subjects diagnosed with ADHD and two studies that were related to the disorder, which evaluated QbTest in medication treatment response. Changes in QbTest data such as Q-scores, effect size, or improvement/deterioration of QbTest variables were evaluated. A clinically relevant decrease in QbTest Q-scores was found in the majority of the studies when treated with any type of ADHD medication in therapeutic doses, both in comparison to placebo and when compared from baseline to endpoint treatment.

Conclusion: QbTest can distinguish pharmacological treatment effects within hours of pharmacological titration and can be used for monitoring of long-term treatment of ADHD. A need for optimization and individualization of medication treatment response could be addressed with access to objective measures in ADHD management.

简介注意缺陷多动障碍(ADHD)被认为是儿童和青少年时期最常见的神经发育障碍之一。药物治疗在该疾病的治疗中发挥着重要作用,而在整个治疗过程中,验证 ADHD 药物的有效性至关重要。QbTest 是一种计算机化测试,其目的是为医护人员提供多动、冲动和注意力不集中的客观测量结果,以帮助对多动症进行临床评估和对治疗干预措施进行评价:对使用 QbTest 监测多动症药物治疗反应的相关文章进行了系统回顾。对 2004 年至 2023 年间发表的文献进行了评估:结果:共有 15 项研究被纳入综述。其中 13 篇文章涉及确诊为多动症的受试者,2 项研究与多动症有关,对 QbTest 在药物治疗反应中的应用进行了评估。研究评估了 QbTest 数据的变化,如 Q 分数、效应大小或 QbTest 变量的改善/恶化。与安慰剂相比,以及与基线治疗到终点治疗相比,大多数研究发现,在使用任何类型的治疗剂量的多动症药物治疗时,QbTest Q分数都会出现与临床相关的下降:结论:QbTest 可在药物滴定后数小时内区分药物治疗效果,并可用于监测多动症的长期治疗。在多动症的治疗过程中,采用客观的测量方法可以满足优化和个性化药物治疗反应的需求。
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引用次数: 0
Understanding the User's Point of View: When the Doctor Gets Sick with Cancer and Seeks Help. 了解用户观点:当医生患上癌症并寻求帮助时。
Q2 Medicine Pub Date : 2023-10-13 eCollection Date: 2023-01-01 DOI: 10.2174/0117450179241325231011070735
Elena Massa, Eleonora Lai, Clelia Donisi, Mario Scartozzi, Laura Orgiano, Olga Mulas, Andrea Pretta, Giovanni Caocci, Mauro Giovanni Carta

Background: When physicians confront a serious personal illness, they may discover that the transition to the "sick" role is challenging and not easy. We conducted a qualitative study in which a group of doctors with cancer (DP) was compared with a group of patients with cancer, not doctors (NDP) but with a degree of education, qualifications, and a professional role comparable to that of a doctor.

Objectives: The main objective was to evaluate the effect of the diagnosis and the treatment of cancer on both the patient's personal and professional life. It was also designed to understand the effect that the experience of cancer may have on the subsequent clinical practice of DP.

Methods: The eligibility criteria included diagnosis of tumors of different sites and at any stage of disease treated with local (surgery, radiotherapy) or systemic (chemotherapy, hormonal, target) therapies or a combination of both; patients actively working. A semi-structured interview was used to collect information about the patient's cancer experiences. In both groups, six main themes and ten subthemes were identified.

Results: From July to November 2021, 59 patients were enrolled in the study. Among them, 29 were DP and 30 were NDP. The median age and gender were 55.9 years ± 9.3 SD (range 38-82 y), M/F ratio 12/17 for DP, and 56.3 years ± 8.9 SD (range 40-83 y), M/F ratio 11/19 for NDP, respectively. The main themes were: theme 1, practical aspects related to diagnosis: most of the DP did not encounter difficulties in performing the tests necessary to confirm the diagnosis of cancer, unlike what was observed in NDP. Theme 2, cancer diagnosis experience: Many DP and NDP felt prepared for their own cancer experience. Two-thirds of DP already knew their cancer prognosis from their previous background knowledge and one-third of NDP did not want to discuss the prognosis in depth with their referring oncologists for the fear of learning that their cancer had a poor prognosis. Theme 3, treatment experience: for many DP, having a professional background contributed to more active participation in care and also in the management of side effects of treatments. Most NDP were satisfied with the treatment received in the hospital and the relationship with the health professionals. Theme 4, changes in work: None of the patients from both the groups stopped working permanently or lost their job because of the disease. A higher number of DP and NDP reported a loss of interest in their job. Theme 5, changes in personal/family life and friendships: more than half of the patients in both groups developed a new perspective on their private lives. Theme 6, comfort from faith: most of the patients in both groups who followed a faith, found comfort in that faith. For DP only, we explored the theme of the change in the doctor/patient relationship. Important findings from our study included positive cha

背景:当医生面临严重的个人疾病时,他们可能会发现向 "病人 "角色的转变充满挑战,而且并不容易。我们进行了一项定性研究,将一组癌症医生(DP)与一组癌症患者(NDP)进行了比较,后者不是医生,但其教育程度、资质和职业角色与医生相当:主要目的是评估癌症诊断和治疗对患者个人生活和职业生活的影响。研究还旨在了解患癌经历可能对民主党随后的临床实践产生的影响:研究对象的资格标准包括:确诊为不同部位的肿瘤、处于任何疾病阶段、接受过局部(手术、放疗)或全身(化疗、激素、靶向)治疗或两者结合治疗的患者;积极工作的患者。我们采用半结构化访谈的方式收集患者的癌症经历。在这两个小组中,确定了六个主要主题和十个次主题:从 2021 年 7 月到 11 月,共有 59 名患者参与了研究。其中,29 人是 DP,30 人是 NDP。中位年龄和性别分别为 55.9 岁 ± 9.3 SD(38-82 岁),男女比例 12/17 (DP)和 56.3 岁 ± 8.9 SD(40-83 岁),男女比例 11/19 (NDP)。主要的主题有:主题 1,与诊断有关的实际问题:大多数民主党人在进行确诊癌症所需的检查时没有遇到困难,这与非民主党人的情况不同。主题 2,癌症诊断经验:许多民主党人和新民主党人对自己的癌症经历有心理准备。三分之二的民主党人已经从他们以前的背景知识中知道了他们的癌症预后,三分之一的新民主党人不想与他们的转诊肿瘤医生深入讨论预后,因为他们害怕得知他们的癌症预后很差。主题 3,治疗经验:对许多民主党人来说,拥有专业背景有助于更积极地参与治疗,也有助于控制治疗的副作用。大多数新民主党人对在医院接受的治疗以及与医护人员的关系感到满意。主题 4:工作变化:两组患者都没有因为疾病而永久停止工作或失去工作。较多的民主党和非民主党患者表示对工作失去了兴趣。主题 5,个人/家庭生活和友谊的变化:两组中都有一半以上的患者对自己的私人生 活有了新的看法。主题 6:信仰带来的安慰:两组中大多数有信仰的病人都在信仰中找到了安慰。仅就 DP 组而言,我们探讨了医患关系变化这一主题。我们研究的重要发现包括医生在临床实践中的积极变化,其中包括与患者建立更加感同身受的关系、更多地考虑癌症对心理的影响,以及更加关注患者报告的某些癌症症状:这项研究表明,有必要了解职业病人的特殊需求,特别是与情绪困难、隐私保护和重返工作岗位后需要支持有关的需求。这些结果有助于改善目前的癌症护理实践。
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引用次数: 0
Effect of Psychosocial Interventions on Cancer's Caregiver Quality of Life: Meta-analysis 心理社会干预对癌症照护者生活质量的影响:meta分析
Q2 Medicine Pub Date : 2023-10-04 DOI: 10.2174/17450179-v19-e230927-2022-ht14-4336-1
C Vasantha Kalyani, Kusum K. Rohilla, Pratima Gupta, Amit Gupta, Sweety Gupta
Background: People living with cancer benefit greatly from informal caregivers. No previous meta-analysis was done to check the effect of psychological intervention on cancer caregiver's quality of life. Objectives: The goal of this meta-analysis was to check the effect of psychosocial interventions on Cancer's Caregiver quality of life and check the impact of various psychological intervention programs. Methods: A comprehensive literature search was conducted from January 2006 to April 2021 using PubMed, PubMed Central, Clinical Key, CINAHL Database, EBSCO, Google Scholar and Cochrane database. Results: The effect of psychological intervention programs on caregiver's quality of life was evaluated using a mean difference between experimental and control groups. A random-effects model was used to measure the mean difference (MD) for calculating the cancer caregiver's quality of life. The final report comprised eight trials with a total of 1142 participants. The caregiver intervention programme was found to improve cancer caregivers' quality of life, but not statistically significantly (mean difference=0.10; p<0.00001). Conclusion: According to this meta-analysis, The psychological intervention program positively affected cancer caregiver's quality of life. Further randomised controlled trials are required to prove that psychological interventional programs are successful strategies for improving cancer caregiver's quality of life.
背景:癌症患者从非正式护理人员中获益良多。以前没有进行meta分析来检查心理干预对癌症护理者生活质量的影响。目的:本荟萃分析的目的是检查心理社会干预对癌症护理者生活质量的影响,并检查各种心理干预方案的影响。方法:综合检索2006年1月至2021年4月PubMed、PubMed Central、Clinical Key、CINAHL数据库、EBSCO、Google Scholar和Cochrane数据库的文献。结果:心理干预方案对照顾者生活质量的影响采用实验组和对照组的平均差异进行评估。随机效应模型用于测量平均差值(MD)来计算癌症护理者的生活质量。最终报告包括8项试验,共有1142名参与者。护理人员干预方案可改善癌症护理人员的生活质量,但无统计学意义(平均差异=0.10;术中,0.00001)。结论:根据本荟萃分析,心理干预计划对癌症护理者的生活质量有积极影响。需要进一步的随机对照试验来证明心理干预方案是改善癌症护理者生活质量的成功策略。
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引用次数: 0
The Intersection between Alcohol use and Sexual Activity among Young Adult Male U.S. Service Members. 美国年轻成年男性服役人员饮酒与性活动的交叉点。
Q2 Medicine Pub Date : 2023-09-06 eCollection Date: 2023-01-01 DOI: 10.2174/17450179-v19-230809-2023-9
Lindsay M Orchowski, Bryce M Meerhaeghe, Amber R Lane, Donna M Kazemi, Brian Borsari, Cristóbal S Berry-Cabán

Aims: The current study explores drinking habits, preferences for alcohol use before sexual activity, and alcohol-related sexual behavior among young adult male active duty service members in the United States.

Background: Hazardous alcohol use is a significant problem among United States military service members. Whereas the association between alcohol use and sexual assault is well documented in civilian samples, less is known regarding the intersection of alcohol use and sexual activity among soldiers.

Objective: Descriptive statistics were utilized to summarize drinking habits, preferences for alcohol use before sexual activity, and alcohol-related sexual behavior.

Methods: A sample of 338 active-duty male service members between the ages of 18 and 24 were recruited from a large military post in the Southeastern United States. Constructs were assessed using self-report surveys.

Results: Participants reported consuming alcohol, on average, 5.6 times over the prior month. Average alcohol consumption was reported to be 7.8 beverages per drinking occasion. Participants reported engaging in heavy drinking an average of 2.9 times over the past 30 days. On average, service members reported a preference for 1.3 drinks before sexual activity. Furthermore, 75.2% of participants preferred to be sober during sex, and 82.1% preferred to engage in sexual activity with a sober partner. Approximately 14% of the sample reported using alcohol to improve their chances of having sex.

Conclusion: These findings highlight high rates of alcohol use among soldiers. Nonetheless, young adult male soldiers report a preference for sexual activity while sober. Understanding the co-occurrence of alcohol use and sexual activity has the potential to inform the development of integrated alcohol and sexual assault prevention programs for service members.

目的:本研究探讨了美国年轻成年男性现役军人的饮酒习惯、性活动前饮酒偏好以及与酒精相关的性行为。背景:危险饮酒是美国军人中的一个重要问题。尽管在平民样本中,酒精使用和性侵犯之间的联系有很好的记录,但关于士兵中酒精使用与性活动的交叉点,人们知之甚少。目的:采用描述性统计方法总结饮酒习惯、性活动前饮酒偏好以及与酒精相关的性行为。方法:从美国东南部的一个大型军事哨所招募了338名年龄在18岁至24岁之间的现役男性服役人员。使用自我报告调查对结构进行评估。结果:参与者报告称,他们在前一个月平均饮酒5.6次。据报告,每次饮酒的平均饮酒量为7.8杯。参与者报告称,在过去30天里,他们平均饮酒2.9次。平均而言,服务人员报告在性活动前更喜欢喝1.3杯饮料。此外,75.2%的参与者更喜欢在性生活中保持清醒,82.1%的人更喜欢与清醒的伴侣进行性活动。大约14%的样本报告说,他们使用酒精来提高性生活的机会。结论:这些发现突出了士兵的高饮酒率。尽管如此,年轻成年男性士兵报告说,他们更喜欢在清醒时进行性活动。了解饮酒和性活动的共同发生,有可能为制定针对服役人员的酒精和性侵犯综合预防计划提供信息。
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引用次数: 0
Dexmedetomidine in the Treatment of Depression: An Up-to-date Narrative Review. 右美托咪定治疗抑郁症:最新叙事综述。
Q2 Medicine Pub Date : 2023-08-30 eCollection Date: 2023-01-01 DOI: 10.2174/17450179-v19-230823-2023-4
Tamadhir Al-Mahrouqi, Mohammed Al Alawi, Rafael C Freire
Depressive disorders (DD) are common, and their prevalence is expected to rise over the next decade. Depressive disorders are linked to significant morbidity and mortality. The clinical conundrum of depressive disorders lies in the heterogeneity of their phenomenology and etiology. Further, the currently available antidepressants have several limitations, including a delayed onset of action, limited efficacy, and an unfavorable side effect profile. In this review, Dexmedetomidine (DEX), a highly selective and potent α2-adrenergic receptor (α2-AR) agonist, is proposed as a potentially novel antidepressant with multiple mechanisms of action targeting various depression pathophysiological processes. These mechanisms include modulation of the noradrenergic system, regulation of neuroinflammation and oxidative stress, influence on the Brain-Derived Neurotrophic Factor (BDNF) levels, and modulation of neurotransmitter systems, such as glutamate. The review begins with an introduction before moving on to a discussion of DEX's pharmacological features. The pathophysiological and phenomenological targets of DD are also explored, along with the review of the existing preclinical and clinical evidence for DEX's putative anti-depressant effects. Finally, the review ends by presenting the pertinent conclusions and future directions.
抑郁症(DD)很常见,预计其患病率将在未来十年内上升。抑郁症与显著的发病率和死亡率有关。抑郁症的临床难题在于其现象学和病因的异质性。此外,目前可用的抗抑郁药有几个局限性,包括起效延迟、疗效有限和不良副作用。在这篇综述中,右美托咪定(DEX)是一种高选择性和强效的α2-肾上腺素能受体(α2-AR)激动剂,被认为是一种潜在的新型抗抑郁药,具有多种针对抑郁症病理生理过程的作用机制。这些机制包括去甲肾上腺素能系统的调节、神经炎症和氧化应激的调节、对脑源性神经营养因子(BDNF)水平的影响以及神经递质系统(如谷氨酸)的调节。这篇综述从引言开始,然后讨论DEX的药理学特征。还探讨了DD的病理生理学和现象学靶点,以及DEX假定的抗抑郁作用的现有临床前和临床证据的综述。最后,审查结束时提出了相关结论和未来方向。
{"title":"Dexmedetomidine in the Treatment of Depression: An Up-to-date Narrative Review.","authors":"Tamadhir Al-Mahrouqi,&nbsp;Mohammed Al Alawi,&nbsp;Rafael C Freire","doi":"10.2174/17450179-v19-230823-2023-4","DOIUrl":"https://doi.org/10.2174/17450179-v19-230823-2023-4","url":null,"abstract":"Depressive disorders (DD) are common, and their prevalence is expected to rise over the next decade. Depressive disorders are linked to significant morbidity and mortality. The clinical conundrum of depressive disorders lies in the heterogeneity of their phenomenology and etiology. Further, the currently available antidepressants have several limitations, including a delayed onset of action, limited efficacy, and an unfavorable side effect profile. In this review, Dexmedetomidine (DEX), a highly selective and potent α2-adrenergic receptor (α2-AR) agonist, is proposed as a potentially novel antidepressant with multiple mechanisms of action targeting various depression pathophysiological processes. These mechanisms include modulation of the noradrenergic system, regulation of neuroinflammation and oxidative stress, influence on the Brain-Derived Neurotrophic Factor (BDNF) levels, and modulation of neurotransmitter systems, such as glutamate. The review begins with an introduction before moving on to a discussion of DEX's pharmacological features. The pathophysiological and phenomenological targets of DD are also explored, along with the review of the existing preclinical and clinical evidence for DEX's putative anti-depressant effects. Finally, the review ends by presenting the pertinent conclusions and future directions.","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"19 ","pages":"e174501792307240"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10507216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71432265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
期刊
Clinical Practice and Epidemiology in Mental Health
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