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The Association of Gender Based Violence (GBV) with Familial and Social Determinants and Mental Health Status of Bengali Married Working Women: A Cross-sectional Study 基于性别的暴力(GBV)与家庭和社会决定因素以及孟加拉已婚职业妇女心理健康状况的关联:一项横断面研究
Q2 Medicine Pub Date : 2023-04-03 DOI: 10.2174/17450179-v19-e230403-2022-29
T. Akter, M. Haque, Md Zobaer Hasan, Faisal Muhammad, Sharmin Sultana, M. G. D. Harun, Md. Shahinuzzaman, Syeda Humayra, Md. Monirul Islam, Sabina Sharmin, Alauddin Chowdhury Abm
Gender Based Violence (GBV) represents a severe violation of women's human rights beyond geographical, cultural, religious, social, and economic aspects. This study aimed to identify the prevalence of GBV, its association with mental health status, and familial and social determinants among the higher socio-economic married working women in Bangladesh. A cross-sectional study was conducted from June to November 2019 among the higher socio-economic married women working in Dhaka. To reach the targeted participants, five hundred sixty participants were recruited using multistage sampling. Women with a minimum graduate degree, monthly income >35000, and working outside were included in this study. A semi-structured questionnaire was used to collect data through a face-to-face interview. Mental health status was measured by 20 items on the CES-D scale. Descriptive statistics and bivariate (unadjusted) and multivariate (adjusted) logistic regression were used to explore the determinants and mental health status. The mean age of participants was 35.7 ± 4.8 years. Around 13.6% of women faced GBV. The age, marriage duration, family type, monthly income, parental status, number of children, and education level showed a significant association with GBV. The binary logistic regression model found that the status of mental health was strongly significant in both unadjusted and adjusted models, OR (95% CI) =2.589 (1.577-4.252) and 4.542 (2.362-8.734). Participation in the family's decision-making process was strongly associated with GBV OR (95% CI) = 4.529 (2.332- 8.796). The attitude of the husband or in-laws was strongly significant in both unadjusted OR (95% CI) = 10.605 (4.988 - 22.548) and adjusted models 5.972 (1.836-19.421). Having a good understanding of the husband was strongly significant in two models, OR (95% CI) = 27.383 (13.568 -55.263) and 17.553 (6.160 -50.018). The odds of GBV, if any family members are suffering from chronic disease, were around six-fold higher among married working women in the unadjusted model OR (95% CI) =5.935 (2.791 - 12.623) and almost eight-fold higher in adjusted model 7.679 (2.293 -25.719). Time for attending social obligation was strongly significant in both unadjusted OR (95% CI)= 11.633 (5.239 -25.832) and adjusted model 24.402 (7.511 -79.277). The GBV prevalence was comparatively low, and it was found to be related to working women with higher socio-economic status. This issue should not be neglected as it impedes the empowerment of women, which is a global concern and developmental plan. Hence, there is a need to formulate better policies and programs to attain a gender-based, violence-free society.
基于性别的暴力(GBV)是对妇女人权的严重侵犯,超出了地域、文化、宗教、社会和经济等方面。本研究旨在确定孟加拉国社会经济地位较高的已婚职业妇女中性别暴力的流行程度、其与心理健康状况的关系以及家庭和社会决定因素。2019年6月至11月,在达卡工作的社会经济地位较高的已婚妇女中进行了一项横断面研究。为了达到目标参与者,采用多阶段抽样方法招募了560名参与者。最低研究生学位,月收入>35000,外出工作的女性被纳入本研究。采用半结构化问卷,通过面对面访谈收集数据。心理健康状况用CES-D量表的20个项目进行测量。采用描述性统计、双变量(未调整)和多变量(调整)logistic回归探讨心理健康状况的影响因素。参与者的平均年龄为35.7±4.8岁。大约13.6%的女性面临性别暴力。年龄、婚姻年限、家庭类型、月收入、父母身份、子女数量、受教育程度与性别暴力有显著相关。二元logistic回归模型发现,未调整模型和调整模型的心理健康状况均有显著性差异,OR (95% CI)分别为2.589(1.577 ~ 4.252)和4.542(2.362 ~ 8.734)。参与家庭决策过程与GBV OR强相关(95% CI) = 4.529(2.332- 8.796)。在未调整的or (95% CI) = 10.605(4.988 ~ 22.548)和调整后的模型(5.972(1.836 ~ 19.421)中,丈夫或公婆的态度均有显著性差异。对丈夫有良好的了解在两个模型中具有强显著性,OR (95% CI) = 27.383(13.568 -55.263)和17.553(6.160 -50.018)。在未调整的模型中,如果任何家庭成员患有慢性疾病,已婚职业女性患GBV的几率约为6倍,OR (95% CI) =5.935(2.791 - 12.623),而在调整后的模型中,OR (95% CI) = 7.679(2.293 -25.719)高出近8倍。参加社会义务的时间在未调整OR (95% CI)= 11.633(5.239 -25.832)和调整模型(24.402(7.511 -79.277)中均具有显著性。性别暴力发生率相对较低,与社会经济地位较高的职业妇女有关。这个问题不应被忽视,因为它妨碍赋予妇女权力,这是一个全球关注的问题和发展计划。因此,有必要制定更好的政策和方案,以实现一个基于性别、无暴力的社会。
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引用次数: 0
Effects of a Life Skills Enhancement Program on the Life Skills and Risk Behaviors of Social Media Addiction in Early Adolescence. 生活技能提升计划对青少年早期社交媒体成瘾的生活技能和风险行为的影响。
Q2 Medicine Pub Date : 2023-02-16 eCollection Date: 2023-01-01 DOI: 10.2174/17450179-v19-e230113-2022-26
Jedbordin Kumkronglek, Pornpen Sirisatayawong, Supat Chupradit

Objective: This research aimed to develop and investigate the effects of a life skills enhancement program on the life skills and risk behaviors of social media addiction in early adolescence.

Methods: This research used a quasi-experimental design for a controlled study with a pre-test and post-test that collected data through a general information questionnaire, Social Media Addiction Screening Scale: S-MASS, and a life skills test. There were 48 samples recruited by purposive sampling from 5 schools in Chiang Mai, Thailand. The life skills enhancement program was developed under the theory of cognitive and behavioral therapy in combination with group therapy or occupational therapy. The program had a total of 10 sessions, with 1 session per week for 60 minutes and 10 weeks in total.

Results: For the results, a statistically significant difference in post-test SMASS scores between the control and experimental group was found (p<0.01). Moreover, a statistically significant difference in the experimental group between pre-test and post-test using S-MASS scores decreased significantly after participating in the program but not in the control group. This result is similar to the comparative data of life skills scores that revealed there was a statistically significant difference between the pre-test and post-test only in the experimental group. For the comparative data between the control and experimental group, however, there were no statistically significant differences in pre-test and post-test life skills scores between the two groups.

Conclusion: From the results, it can be summarized that the life skills enhancement program had affected an increase in life skills and a decrease in risky social media usage among adolescents.

目的:本研究旨在开发和调查生活技能增强计划对青春期早期社交媒体成瘾的生活技能和风险行为的影响。方法:本研究采用准实验设计进行对照研究,包括前测和后测,通过一般信息问卷、社交媒体成瘾筛查量表:S-MASS和生活技能测试收集数据。通过有目的的抽样,从泰国清迈的5所学校招募了48名样本。生活技能提升计划是在认知和行为疗法的理论下,结合团体疗法或职业疗法开发的。该项目共有10节课,每周1节,每次60分钟,共10周。结果:对于结果,对照组和实验组的测试后SMASS得分存在统计学显著差异(P结论:从结果中可以总结出,生活技能增强计划影响了青少年生活技能的提高和社交媒体使用风险的降低。
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引用次数: 1
The Sex Differences in Cortisol Concentrations, Anxiety, and Depressive Mood In Moroccan Youth 摩洛哥青年皮质醇浓度、焦虑和抑郁情绪的性别差异
Q2 Medicine Pub Date : 2023-02-15 DOI: 10.2174/17450179-v19-e230215-2022-24
I. Rammouz, M. Nakajima, S. Boujraf, R. Aalouane, A. Lemieux, M. al’Absi
Evidence indicates sex differences in stress response and mental health challenges. Psychobiological research of early symptoms of psychopathology has suggested that cortisol, as a marker of stress, is positively associated with depressive mood and anxiety in adolescents. To date, no study has examined sex differences in the relationships between cortisol levels and negative mood among Moroccan youth. A total of 332 Moroccan secondary students (171 female) aged 11 to 20 completed a range of psychological measures and provided two morning saliva samples across atwo-hour period. We hypothesized that females would show greater levels of depression and anxiety symptoms than males. We also anticipated positive relationships between cortisol and those symptoms. The results demonstrated the expected cortisol morning decline due to the diurnal pattern. Higher anxiety (p < .001), higher depressive mood (p < .001), and more clinically relevant depression were found in the females (47.7%) than the males (22.5%; p < .001). In addition, anxiety (p < .05) was positively associated with later morning cortisol in females but not males. Our results demonstrated sex differences in depressive mood among youth and the feasibility of psychobiological stress research in Morocco. More research is needed to identify sex-specific factors of depression and anxiety. Such effort would inform strategies to tailor treatment programs for females and males.
有证据表明,性别在压力反应和心理健康挑战方面存在差异。精神病理早期症状的心理生物学研究表明,皮质醇作为压力的标志,与青少年的抑郁情绪和焦虑呈正相关。迄今为止,还没有研究调查摩洛哥青年皮质醇水平和消极情绪之间的性别差异。共有332名11至20岁的摩洛哥中学生(171名女性)完成了一系列心理测量,并在两个小时的时间内提供了两次早晨的唾液样本。我们假设女性会比男性表现出更严重的抑郁和焦虑症状。我们还预计皮质醇与这些症状之间存在正相关关系。结果表明,由于昼夜模式,预期的皮质醇在早晨下降。女性患者焦虑程度(p < 0.001)、抑郁情绪(p < 0.001)、临床相关抑郁程度(47.7%)均高于男性(22.5%;P < 0.001)。此外,焦虑与女性上午晚些时候的皮质醇呈正相关(p < 0.05),而与男性无关。我们的研究结果证明了青少年抑郁情绪的性别差异和摩洛哥心理生物学应激研究的可行性。需要更多的研究来确定抑郁和焦虑的性别特异性因素。这样的努力将有助于制定针对女性和男性的治疗方案。
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引用次数: 0
Systematic Review and Meta-Analysis of Health-Related Quality of Life in Patients with β-Thalassemia that Underwent Hematopoietic Stem Cell Transplantation 接受造血干细胞移植的β-地中海贫血患者健康相关生活质量的系统评价和荟萃分析
Q2 Medicine Pub Date : 2023-01-05 DOI: 10.2174/17450179-v17-e211208-2021-ht2-1910-4
Olga Mulas, Ilaria Pili, Marco Sanna, Giorgio La Nasa
Background: β-Thalassemia major (β-TM) represents one of the most important hemoglobinopathies worldwide. Remarkable improvements have been achieved in supportive therapy based on blood transfusions and iron chelation, and nowadays, this approach is capable of assuring a long life in these patients in industrialized countries. The only curative treatment is represented by hematopoietic stem cell transplantation (HSCT). However, this treatment may be burdened by deterioration in the Health-Related Quality of Life (HRQoL). This paper aimed to evaluate the role of HRQoL in transplanted β-TM patients with a systematic review and meta-analysis. Methods: PubMed database, Web of Science, and Scopus were systematically searched for studies published between January 1st, 2000 to September 2020. The following terms were entered in the database queries: β-thalassemia, HRQoL, and HSCT. The study was carried out according to the Preferred Reporting Items for Systematic and Meta-analyses (PRISMA) statement. Results: We identified a total of 33 potential studies. Among these, 10 were finally considered in the systematic review and 5 in the meta-analysis. Overall, good scores in the principal domains of HRQoL were reported by transplanted patients. These data were confirmed by results of meta-analysis that showed significant difference between transplanted and β-TM patients treated with conventional therapy in the physical and emotional dimension, with a medium effect size [d=0.65, 95% CI (0.29-1.02), z = 3.52, p =0.0004, I 2 =75%; and d=0.59, 95% CI (0.43-0.76), z = 6.99, p <0.00001, I 2 =0%, respectively]. Conclusion: HRQoL is generally good in β-TM transplanted patients and may significantly contribute in deciding whether or not to transplant a β-TM patient treated with conventional therapy.
背景:β-地中海贫血(β-TM)是世界上最重要的血红蛋白病之一。以输血和铁螯合为基础的支持治疗取得了显著的进步,如今,这种方法能够确保工业化国家这些患者的长寿。唯一的治愈方法是造血干细胞移植(HSCT)。然而,这种治疗可能会因健康相关生活质量(HRQoL)的恶化而负担过重。本文旨在通过系统综述和荟萃分析来评价HRQoL在移植β-TM患者中的作用。方法:系统检索2000年1月1日至2020年9月期间发表的PubMed数据库、Web of Science和Scopus。在数据库查询中输入以下术语:β-地中海贫血、HRQoL和HSCT。本研究按照系统和荟萃分析首选报告项目(PRISMA)声明进行。结果:我们共确定了33项潜在的研究。其中10个最终纳入系统评价,5个纳入meta分析。总的来说,移植患者在HRQoL的主要领域获得了良好的评分。meta分析结果证实了这些数据,移植β-TM患者与常规治疗的β-TM患者在身体和情绪方面存在显著差异,效应量中等[d=0.65, 95% CI (0.29-1.02), z = 3.52, p =0.0004, I 2 =75%;d=0.59, 95% CI (0.43-0.76), z = 6.99, p <0.00001, i2 =0%]。结论:β-TM移植患者的HRQoL普遍较好,可能是决定β-TM移植患者是否接受常规治疗的重要因素。
{"title":"Systematic Review and Meta-Analysis of Health-Related Quality of Life in Patients with β-Thalassemia that Underwent Hematopoietic Stem Cell Transplantation","authors":"Olga Mulas, Ilaria Pili, Marco Sanna, Giorgio La Nasa","doi":"10.2174/17450179-v17-e211208-2021-ht2-1910-4","DOIUrl":"https://doi.org/10.2174/17450179-v17-e211208-2021-ht2-1910-4","url":null,"abstract":"Background: β-Thalassemia major (β-TM) represents one of the most important hemoglobinopathies worldwide. Remarkable improvements have been achieved in supportive therapy based on blood transfusions and iron chelation, and nowadays, this approach is capable of assuring a long life in these patients in industrialized countries. The only curative treatment is represented by hematopoietic stem cell transplantation (HSCT). However, this treatment may be burdened by deterioration in the Health-Related Quality of Life (HRQoL). This paper aimed to evaluate the role of HRQoL in transplanted β-TM patients with a systematic review and meta-analysis. Methods: PubMed database, Web of Science, and Scopus were systematically searched for studies published between January 1st, 2000 to September 2020. The following terms were entered in the database queries: β-thalassemia, HRQoL, and HSCT. The study was carried out according to the Preferred Reporting Items for Systematic and Meta-analyses (PRISMA) statement. Results: We identified a total of 33 potential studies. Among these, 10 were finally considered in the systematic review and 5 in the meta-analysis. Overall, good scores in the principal domains of HRQoL were reported by transplanted patients. These data were confirmed by results of meta-analysis that showed significant difference between transplanted and β-TM patients treated with conventional therapy in the physical and emotional dimension, with a medium effect size [d=0.65, 95% CI (0.29-1.02), z = 3.52, p =0.0004, I 2 =75%; and d=0.59, 95% CI (0.43-0.76), z = 6.99, p <0.00001, I 2 =0%, respectively]. Conclusion: HRQoL is generally good in β-TM transplanted patients and may significantly contribute in deciding whether or not to transplant a β-TM patient treated with conventional therapy.","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"256 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135323989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Effects of Tyrosine Kinase Inhibitors (TKIs) in Monotherapy and with Add-on Treatments on Health-related Quality of Life of People with Chronic Myeloid Leukemia: A Systematic Review of Randomized-Controlled Trials 酪氨酸激酶抑制剂(TKIs)在单药治疗和附加治疗中对慢性髓系白血病患者健康相关生活质量的影响:随机对照试验的系统评价
Q2 Medicine Pub Date : 2023-01-05 DOI: 10.2174/17450179-v17-e211118-2021-ht2-1910-12
Antonio E. Nardi, Federica Sancassiani, Vanessa Barrui, Goce Kalcev, Veronica Uras, Giulia Meloni, Luigi Marongiu, Giorgio Tamburini, Alberto Maleci, Laiana A. Quagliato, Giorgio La Nasa, Mauro Giovanni Carta
Background: The era of establishing tyrosine kinase inhibitors (TKIs) in the treatment of chronic myeloid leukemia (CML) changed the outcome and the course of this life-threatening malignancy. People suffering from CML have now a better prognosis and a longer life expectancy due to the development of TKIs, even if it requires long-term, often lifelong, treatments that are nonetheless associated with improved Health-related Quality of life (HRQoL). However, data on the effects of TKIs on HRQoL are not always systematic; sometimes the data have been obtained by studies different from RCTs, or without a clear definition of what HRQoL is. The main purpose of this systematic review is to summarize all randomized-controlled trials (RCTs) including HRQoL as main or secondary outcome in patients with CML treated with TKIs or with TKIs plus an add-on treatment. Methods: A systematic review has been conducted by searching the relevant papers in PubMed/Medline and Web of Science with the following keywords: “quality of life” OR “health-related quality of life” OR “QoL” OR “HRQoL” OR “H-QoL” AND “chronic myeloid leukemia”. Interval was set from January 2000 to December 2020. Results: 40 papers were identified through the search. Out of them, 7 RCTs were included. All the studies used standardized measures to assess HRQoL, even not always specific for CML. 5 RCTs randomized subjects to 2 or 3 arms to evaluate the effects of TKIs of the first, second and third generation in monotherapy. 2 RCTs randomized subjects to TKI therapy plus an add-on treatment versus TKI therapy as usual. The results of all these trials were examined and discussed. Conclusion: All the included RCTs pointed out significant findings regarding the positive effects of TKIs on HRQoL of people with CML, both when they were used in monotherapy or, notably, with an add-on treatment to enhance TKIs effects.
背景:建立酪氨酸激酶抑制剂(TKIs)治疗慢性髓性白血病(CML)的时代改变了这种危及生命的恶性肿瘤的结局和病程。由于tki的发展,患有CML的人现在有更好的预后和更长的预期寿命,即使它需要长期的,通常是终身的治疗,但与健康相关的生活质量(HRQoL)的改善有关。然而,tki对HRQoL影响的数据并不总是系统性的;有时数据是通过与随机对照试验不同的研究获得的,或者没有明确定义HRQoL是什么。本系统综述的主要目的是总结所有随机对照试验(RCTs),包括HRQoL作为CML患者接受TKIs治疗或TKIs加附加治疗的主要或次要结局。方法:以“生活质量”或“健康相关生活质量”或“QoL”或“HRQoL”或“H-QoL”和“慢性髓系白血病”为关键词,在PubMed/Medline和Web of Science中检索相关论文进行系统综述。时间间隔为2000年1月至2020年12月。结果:共检索到40篇论文。其中纳入7项随机对照试验。所有的研究都使用标准化的方法来评估HRQoL,即使并不总是针对CML。5项随机对照试验将受试者随机分为2或3组,以评估第一代、第二代和第三代TKIs在单药治疗中的效果。2项随机对照试验将受试者随机分为TKI治疗加附加治疗组和常规TKI治疗组。对所有这些试验的结果进行了检验和讨论。结论:所有纳入的随机对照试验都指出了TKIs对CML患者HRQoL的积极作用的显著发现,无论是在单一治疗中使用,还是在附加治疗中使用以增强TKIs的作用。
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引用次数: 0
Mixed Depression: A Survey on Psychopathological, Diagnostic, and Therapeutic Approaches among a Sample of Italian Psychiatrists 混合抑郁症:意大利精神病学家样本中精神病理学、诊断和治疗方法的调查
Q2 Medicine Pub Date : 2021-12-31 DOI: 10.2174/1745017902117010331
L. Mineo, A. Rodolico, C. Concerto, A. Natale, Manuela Pennisi, M. Tusconi, A. Aguglia, A. Amerio, G. Serafini, M. Amore, E. Aguglia
The Diagnostic and Statistical Manual for Mental Disorders (5th edition) introduced the specifier “with Mixed Features” to the diagnosis of Major Depressive Episode to designate the presence of (hypo) manic symptoms as part of the clinical presentation. This change has led to renewed attention on the operational definition, diagnosis, and treatment of Mixed Depression. To investigate the diagnostic and therapeutic approaches towards Mixed Depression among a representative sample of Italian psychiatrists. Between March and April 2021, 342 psychiatrists working in Italian adult mental health services were invited to participate in an anonymous online survey comprising 32 questions designed to investigate clinical and psychopathological approaches regarding the management of mixed depression in daily psychiatric practice. 83.74% of participants reported having performed a diagnosis of mixed depression in the last five years, with the majority of respondents affirming that they had not used any diagnostic tool. Only 7,5% of the surveyed psychiatrists considered the DSM-5 criteria to be fully adequate in the description of this clinical entity. The most used pharmacological approach was combined therapy, in particular antipsychotics plus mood stabilizers. For monotherapy, the preferred drugs were Valproate and Quetiapine. Regarding the conceptualization of mood disorders, 199 of the participants chose the Kraepelinian unitary spectrum view; meanwhile, 101 expressed their preference for the binary model. Our results suggest a prominent position of mixed depression in the context of mood disorders. Univocal operational criteria and additional research on pharmacological treatment are also needed to ensure the correct recognition and management of mixed depression.
《精神疾病诊断与统计手册》(第5版)在诊断重度抑郁发作时引入了“混合特征”的说明词,以指定(轻度)躁狂症状的存在,作为临床表现的一部分。这一变化引起了对混合性抑郁症的操作定义、诊断和治疗的重新关注。在意大利精神病学家的代表性样本中调查混合性抑郁症的诊断和治疗方法。在2021年3月至4月期间,342名在意大利成人心理健康服务机构工作的精神科医生被邀请参加了一项匿名在线调查,该调查包括32个问题,旨在调查日常精神病学实践中有关混合性抑郁症管理的临床和精神病理学方法。83.74%的参与者报告在过去五年中进行了混合性抑郁症的诊断,大多数受访者确认他们没有使用任何诊断工具。只有7.5%的受访精神科医生认为DSM-5标准在描述这一临床实体时是完全充分的。最常用的药理学方法是联合治疗,特别是抗精神病药物加情绪稳定剂。对于单药治疗,首选药物是丙戊酸钠和喹硫平。在情绪障碍概念化方面,199名被试选择Kraepelinian统一谱观;同时,101人表示他们更倾向于二元模型。我们的研究结果表明,混合性抑郁症在情绪障碍的背景下具有突出的地位。还需要明确的操作标准和进一步的药物治疗研究,以确保正确识别和管理混合性抑郁症。
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引用次数: 0
Systematic Review and Meta-Analysis of Health-Related Quality of Life in Patients with β-Thalassemia Underwent Hematopoietic Stem Cell Transplantation 接受造血干细胞移植的β-地中海贫血患者健康相关生活质量的系统评价和荟萃分析
Q2 Medicine Pub Date : 2021-12-08 DOI: 10.2174/17450179-v17-e211208-cpemh-2021-ht2-1910-4
O. Mulas, Ilaria Pili, Marco Sanna, Giorgio La Nasa
β-Thalassemia major (β-TM) represents one of the most important hemoglobinopathies worldwide. Remarkable improvements have been achieved in supportive therapy, based on blood transfusions and iron chelation, and nowadays this approach is capable to assure a long life in these patients in industrialized countries. The only curative treatment is represented by hematopoietic stem cell transplantation (HSCT). However, this treatment may be burdened by deterioration in the Health-Related Quality of Life (HRQoL). The aim of this paper was to evaluate with a systematic review and meta-analysis the role of HRQoL in transplanted β-TM patients. PubMed database, Web of Science and Scopus were systematically searched for studies published between January 1st, 2000 to September, 2020; the following terms were entered in the database queries: β-thalassemia, HRQoL and HSCT. The study was carried out according to the Preferred Reporting Items for Systematic and Meta-analyses (PRISMA) statement. We identified a total of 33 potential studies. Among these, 10 were finally considered in the systematic review and 5 in the meta-analysis. Overall, good scores in the principal domains of HRQoL were reported by transplanted patients. These data were confirmed by results of meta-analysis that showed significant difference between transplanted and β-TM patients treated with a conventional therapy in Physical an Emotional Function dimension, with a medium effect size (d=0.65, (95% CI (0.29-1.02) z = 3.52, p =0.0004, I2=75% and d=0.59, (95% CI (0.43-0.76) z = 6.99, p <0.00001, I2=0% respectively). HRQoL is generally good in β-TM transplanted patients and may give a significant contribute the difficult choice whether transplant or not a β-TM patient treated with conventional therapy.
β-地中海贫血(β-TM)是世界上最重要的血红蛋白病之一。在以输血和铁螯合为基础的支持治疗方面已经取得了显著的进步,如今这种方法能够确保工业化国家这些患者的长寿。唯一的治愈方法是造血干细胞移植(HSCT)。然而,这种治疗可能会因健康相关生活质量(HRQoL)的恶化而负担过重。本文的目的是通过系统回顾和荟萃分析来评估HRQoL在移植β-TM患者中的作用。系统检索PubMed数据库、Web of Science和Scopus数据库2000年1月1日至2020年9月间发表的研究;在数据库查询中输入以下术语:β-地中海贫血、HRQoL和HSCT。本研究按照系统和荟萃分析首选报告项目(PRISMA)声明进行。我们总共确定了33项潜在的研究。其中10个最终纳入系统评价,5个纳入meta分析。总的来说,移植患者在HRQoL的主要领域获得了良好的评分。meta分析结果证实了这些数据,移植β-TM患者与常规治疗的β-TM患者在生理和情绪功能维度上存在显著差异,具有中等效应量(d=0.65, 95% CI (0.29-1.02) z = 3.52, p =0.0004, I2=75%, d=0.59, 95% CI (0.43-0.76) z = 6.99, p <0.00001, I2=0%)。β-TM移植患者的HRQoL普遍较好,这可能是β-TM患者接受常规治疗是否移植的困难选择的重要因素。
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引用次数: 1
The effects of Tyrosine Kinase Inhibitors (TKIs) in monotherapy and with add-on treatments on Health-related Quality of Life of People with Chronic Myeloid Leukemia: a systematic review of Randomized-Controlled Trials. 酪氨酸激酶抑制剂(TKIs)在单药治疗和附加治疗中对慢性髓系白血病患者健康相关生活质量的影响:随机对照试验的系统回顾
Q2 Medicine Pub Date : 2021-11-18 DOI: 10.2174/17450179-v17-e211118-cpemh-2021-ht2-1910-12
A. E. Nardi, F. Sancassiani, Vanessa Barrui, G. Kalcev, V. Uras, Giulia Meloni, Luigi Marongiu, Giorgio Tamburini, Alberto Maleci, Laiana A. Quagliato, Giorgio La Nasa, M. Carta
The era of establishing tyrosine kinase inhibitors (TKIs) in the treatment of chronic myeloid leukemia (CML) changed the outcome and the course of this life-threatening malignancy. People suffering from CML have now a better prognosis and a longer life expectancy by the development of TKIs, even if it requires long term—often lifelong— treatments that are nonetheless associated with improved Health-related Quality of life (HRQoL). However, data on the effects of TKIs on HRQoL are not always systematic: sometimes they were obtained by studies different from RCTs, or without a clear definition of what HRQoL is. The main purpose of this systematic review is to summarize all randomized-controlled trials (RCTs) including HRQoL as main or secondary outcome in patients with CML treated with TKIs or with TKIs plus an add-on treatment. Systematic review by searching for relevant papers in PubMed/Medline and Web of Science with the following keywords: “quality of life” OR “health-related quality of life” OR “QoL” OR “HRQoL” OR “H-QoL” AND “chronic myeloid leukemia”. Interval was set from January 2000 to December 2020. 40 papers were identified through the search. Out of them, 7 RCTs were included. All the studies used standardized measures to assess HRQoL, even not always specific for CML. 5 RCTs randomized subjects to 2 or 3 arms to evaluate the effects of TKIs of the first, second and third generation in monotherapy. 2 RCTs randomized subjects to TKI therapy plus an add-on treatment versus TKI therapy as usual. The results of all these trials were examined and discussed. All the included RCTs pointed out significant findings about the positive effects of TKIs on HRQoL of people with CML, both when they were used in monotherapy or, notably, with an add-on treatment to enhance TKIs effects.
建立酪氨酸激酶抑制剂(TKIs)治疗慢性髓性白血病(CML)的时代改变了这种危及生命的恶性肿瘤的结局和病程。由于tki的发展,患有CML的人现在有更好的预后和更长的预期寿命,即使它需要长期(通常是终身)治疗,但与健康相关的生活质量(HRQoL)的改善有关。然而,tki对HRQoL影响的数据并不总是系统的:有时这些数据是通过与随机对照试验不同的研究获得的,或者没有明确定义HRQoL是什么。本系统综述的主要目的是总结所有随机对照试验(RCTs),包括HRQoL作为CML患者接受TKIs治疗或TKIs加附加治疗的主要或次要结局。系统检索PubMed/Medline和Web of Science相关论文,关键词:“生活质量”或“健康相关生活质量”或“QoL”或“HRQoL”或“H-QoL”和“慢性髓性白血病”。时间间隔为2000年1月至2020年12月。通过搜索确定了40篇论文。其中纳入7项随机对照试验。所有的研究都使用标准化的方法来评估HRQoL,即使并不总是针对CML。5项随机对照试验将受试者随机分为2或3组,以评估第一代、第二代和第三代TKIs在单药治疗中的效果。2项随机对照试验将受试者随机分为TKI治疗加附加治疗组和常规TKI治疗组。对所有这些试验的结果进行了检验和讨论。所有纳入的随机对照试验都指出了TKIs对CML患者HRQoL的积极影响的显著发现,无论是在单药治疗中使用,还是在附加治疗中使用以增强TKIs的效果。
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引用次数: 0
The prevalence of four types of childhood maltreatment in denmark. 丹麦儿童虐待的四种类型。
Q2 Medicine Pub Date : 2013-10-04 eCollection Date: 2013-01-01 DOI: 10.2174/1745017901309010149
Mogens N Christoffersen, Cherie Armour, Mathias Lasgaard, Tonny E Andersen, Ask Elklit

Objectives: To estimate the prevalence of four types of childhood maltreatment in Denmark while taking into considerations how each of the types of maltreatment vary as a function of gender or child-protection status.

Methods: Data were collected from a Danish national study conducted by The Danish National Centre for Social Research in 2008 and 2009. The study used a stratified random probability sample of young people aged 24 years. A sample of 4718 young adults were randomly selected by Statistics Denmark using the total birth cohort of all children born in 1984. The response rate was 63% leaving a total effective sample size of 2980. A structured residential or telephone interview enquired about a range of respondents maltreatment experiences.

Results: Maltreatment is experienced by a significant proportion of Danish children. The reported prevalence rates were; physical neglect (3.0%), emotional abuse (5.2%), physical abuse (5.4%) and sexual abuse (3.4%). All trauma types were experienced by a greater percentage of females compared to males with the exception of physical abuse and all trauma types were experienced by a greater percentage of children given child-protection status.

Conclusions: Female children and children who are given child protection status are those most at risk for experiencing maltreatment in Denmark. However, variability in prevalence rates of maltreatment across studies is problematic. Methodological variations and variation in abuse definitions may be partly attributable.

目的:估计丹麦四种类型的儿童虐待的流行程度,同时考虑到每种类型的虐待如何随着性别或儿童保护状况的变化而变化。方法:数据收集自丹麦国家社会研究中心于2008年和2009年进行的一项丹麦国家研究。该研究使用了一个分层随机概率的24岁年轻人样本。丹麦统计局使用1984年出生的所有儿童的总出生队列随机选择了4718名年轻人的样本。应答率为63%,总有效样本量为2980。结构化的住宅或电话访谈询问了一系列受访者的虐待经历。结果:丹麦儿童遭受虐待的比例很大。报告的患病率为;身体忽视(3.0%)、精神虐待(5.2%)、身体虐待(5.4%)和性虐待(3.4%)。除身体虐待外,所有类型的创伤中女性的比例都高于男性,所有类型的创伤中获得儿童保护地位的儿童的比例都高于男性。结论:在丹麦,女童和获得儿童保护地位的儿童最容易遭受虐待。然而,不同研究中虐待发生率的差异是有问题的。方法的不同和滥用定义的不同可能是部分原因。
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引用次数: 66
Diagnostic Accuracy of the Primary Care Screener for Affective Disorder (PC-SAD) in Primary Care. 初级保健筛查对初级保健中情感性障碍(PC-SAD)的诊断准确性。
Q2 Medicine Pub Date : 2013-10-04 eCollection Date: 2013-01-01 DOI: 10.2174/1745017901309010164
Angelo Picardi, D A Adler, W H Rogers, I Lega, M P Zerella, G Matteucci, L Tarsitani, M Caredda, A Gigantesco, M Biondi

Background: Depression goes often unrecognised and untreated in non-psychiatric medical settings. Screening has recently gained acceptance as a first step towards improving depression recognition and management. The Primary Care Screener for Affective Disorders (PC-SAD) is a self-administered questionnaire to screen for Major Depressive Disorder (MDD) and Dysthymic Disorder (Dys) which has a sophisticated scoring algorithm that confers several advantages. This study tested its performance against a 'gold standard' diagnostic interview in primary care.

Methods: A total of 416 adults attending 13 urban general internal medicine primary care practices completed the PC-SAD. Of 409 who returned a valid PC-SAD, all those scoring positive (N=151) and a random sample (N=106) of those scoring negative were selected for a 3-month telephone follow-up assessment including the administration of the Structured Clinical Interview for DSM-IV-TR Axis I Disorders (SCID-I) by a psychiatrist who was masked to PC-SAD results.

Results: Most selected patients (N=212) took part in the follow-up assessment. After adjustment for partial verification bias the sensitivity, specificity, positive and negative predictive value for MDD were 90%, 83%, 51%, and 98%. For Dys, the corresponding figures were 78%, 79%, 8%, and 88%.

Conclusions: While some study limitations suggest caution in interpreting our results, this study corroborated the diagnostic validity of the PC-SAD, although the low PPV may limit its usefulness with regard to Dys. Given its good psychometric properties and the short average administration time, the PC-SAD might be the screening instrument of choice in settings where the technology for computer automated scoring is available.

背景:在非精神医学环境中,抑郁症往往未被识别和治疗。最近,筛查作为改善抑郁症识别和管理的第一步得到了认可。情感障碍初级保健筛查(PC-SAD)是一种自我管理的问卷,用于筛查重度抑郁障碍(MDD)和心境恶劣障碍(Dys),它具有复杂的评分算法,具有几个优点。这项研究针对初级保健的“黄金标准”诊断面谈测试了它的表现。方法:共有416名参加13个城市普通内科初级保健诊所的成年人完成了PC-SAD。在409名返回有效PC-SAD的患者中,选择所有得分为阳性的(N=151)和随机抽样(N=106)得分为阴性的患者进行为期3个月的电话随访评估,包括由一名对PC-SAD结果不知情的精神科医生进行DSM-IV-TR轴I障碍(SCID-I)的结构化临床访谈。结果:大部分入选患者(N=212)参加了随访评估。调整部分验证偏倚后,MDD的敏感性、特异性、阳性预测值和阴性预测值分别为90%、83%、51%和98%。对于Dys,相应的数字分别为78%,79%,8%和88%。结论:虽然一些研究的局限性提示在解释我们的结果时要谨慎,但本研究证实了PC-SAD的诊断有效性,尽管低PPV可能会限制其对Dys的有用性。鉴于其良好的心理测量特性和较短的平均管理时间,PC-SAD可能是在计算机自动评分技术可用的环境中选择的筛选工具。
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引用次数: 4
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Clinical Practice and Epidemiology in Mental Health
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