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Attachment and parenting in adult patients with anxiety disorders. 成年焦虑症患者的依恋与父母教养。
Q2 Medicine Pub Date : 2013-10-04 eCollection Date: 2013-01-01 DOI: 10.2174/1745017901309010157
Angelo Picardi, Emanuele Caroppo, Elisa Fabi, Serena Proietti, Giancarlo Di Gennaro, Giulio Nicolò Meldolesi, Giovanni Martinotti

Background: The literature suggests that dysfunctional parenting and insecure attachment may increase risk of anxiety-related psychopathology. This study aimed at testing the association between anxiety disorders, attachment insecurity and dysfunctional parenting while controlling for factors usually not controlled for in previous studies, such as gender, age, and being ill.

Methods: A sample of 32 non-psychotic inpatients with SCID-I diagnosis of an anxiety disorder, either alone or in comorbidity, was compared with two age- and sex-matched control groups consisting of 32 non-clinical participants and 32 in-patients with drug-resistant epilepsy. Study measures included the Experience in Close Relationships questionnaire (ECR) and the Parental Bonding Instrument (PBI).

Results: The patients with anxiety disorders scored significantly higher on attachment-related anxiety and avoidance than patients with drug-resistant epilepsy and non-clinical participants. These findings were independent of comorbidity for mood disorders. ECR scores did not differ among diagnostic subgroups (generalized anxiety disorder, panic disorder, other anxiety disorders). Patients with anxiety disorders scored significantly lower on PBI mother's care and borderline significantly lower on PBI father's care than patients with drug-resistant epilepsy.

Conclusions: Although limitations such as the relatively small sample size and the cross-sectional nature suggest caution in interpreting these findings, they are consistent with the few previous adult studies performed on this topic and corroborate Bowlby's seminal hypothesis of a link between negative attachment-related experiences, attachment insecurity, and clinical anxiety. Attachment theory provides a useful theoretical framework for integrating research findings from several fields concerning the development of anxiety disorders and for planning therapeutic interventions.

背景:文献表明,不正常的养育方式和不安全的依恋可能会增加焦虑相关精神病理的风险。本研究旨在测试焦虑障碍、依恋不安全感和功能失调养育之间的关系,同时控制了以往研究中通常不受控制的因素,如性别、年龄和疾病。方法:将32例诊断为焦虑障碍的非精神病性SCID-I住院患者(单独或合并症)与年龄和性别匹配的对照组(32名非临床参与者和32名耐药癫痫住院患者)进行比较。研究方法包括亲密关系体验问卷(ECR)和亲代关系量表(PBI)。结果:焦虑障碍患者的依恋相关焦虑和回避得分明显高于耐药癫痫患者和非临床参与者。这些发现与情绪障碍的合并症无关。ECR评分在诊断亚组(广泛性焦虑障碍、惊恐障碍和其他焦虑障碍)之间没有差异。与耐药癫痫患者相比,焦虑障碍患者在PBI母亲护理方面得分明显较低,在PBI父亲护理方面得分显著低于边缘性癫痫患者。结论:尽管样本量相对较小和横断面性质等局限性提示在解释这些发现时要谨慎,但它们与先前针对该主题进行的少数成人研究一致,并证实了Bowlby关于消极依恋相关经历、依恋不安全感和临床焦虑之间联系的重要假设。依恋理论为整合有关焦虑障碍发展的多个领域的研究成果和规划治疗干预提供了一个有用的理论框架。
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引用次数: 24
Child and Adolescent Behavior Inventory (CABI): A New Instrument for Epidemiological Studies and Pre-Clinical Evaluation. 儿童和青少年行为量表(CABI):流行病学研究和临床前评估的新工具。
Q2 Medicine Pub Date : 2013-01-01 Epub Date: 2013-02-22 DOI: 10.2174/1745017901309010051
Carlo Cianchetti, Andrea Pittau, Valeria Carta, Grazia Campus, Roberta Littarru, Maria Giuseppina Ledda, Alessandro Zuddas, Giuseppina Sannio Fancello

Background: Some questionnaires have already been elaborated to collect information from parents of children and adolescents, both as preparation for clinical evaluation and for screening and epidemiological studies. Here a new questionnaire, the CABI, is proposed, and it is validated in a population of 8-10 year-old children. Compared to existing questionnaires, the CABI has been organized so as to be of medium length, with items concerning the most significant symptoms indicated by the DSM-IV-TR for the pertinent disorders, and covering a wider range than existing instruments. There is no charge for its use.

Methods: The answers of the parents of 302 children in the last 3 years of primary school provided the normative data. A discriminant validation was done for internalizing and externalizing disorders and as a comparison with self-administered anxiety and depression scales. Exploratory factor analysis and internal consistency were also performed.

Results: Distribution of scores on the main scales in the normal population shows positive skewness, with the most frequent score being zero. A highly discriminant capability was found in regard to the sample of children with internalizing and externalizing disorders, with high correlation with the self-administered anxiety and depression scales.

Conclusion: The CABI appears to be capable, at least for 8-10 year-old children, of effectively discriminating those with pathological symptoms from those without. Compared with the widely- used CBCL, it has the advantages of a lower number of items, which should facilitate parental collaboration especially in epidemiological studies, and of being free of charge.

背景:已经编制了一些问卷,从儿童和青少年的父母那里收集信息,作为临床评价和筛查及流行病学研究的准备工作。本文提出了一种新的调查问卷,CABI,并在8-10岁的儿童群体中进行了验证。与现有问卷相比,CABI的组织方式是中等长度,其项目涉及DSM-IV-TR中有关疾病的最显著症状,涵盖范围比现有工具更广。它的使用是免费的。方法:对302名儿童小学前3年的家长进行问卷调查,提供规范性数据。对内化和外化障碍进行了判别验证,并与自我管理的焦虑和抑郁量表进行了比较。并进行探索性因子分析和内部一致性分析。结果:各主要量表得分在正常人群中的分布呈正偏态,最常见的是得分为零。在内化和外化障碍儿童样本中发现了高度的判别能力,与自我管理的焦虑和抑郁量表高度相关。结论:至少对于8-10岁的儿童,CABI似乎能够有效地区分有病理症状的儿童和没有病理症状的儿童。与广泛使用的CBCL相比,它的优点是项目数量少,有利于父母的合作,特别是在流行病学研究中,而且是免费的。
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引用次数: 16
Childhood determinants of adult psychiatric disorder. 成人精神障碍的童年决定因素。
Q2 Medicine Pub Date : 2013-01-01 Epub Date: 2013-02-22 DOI: 10.2174/1745017901309010001
Tom Fryers, Traolach Brugha

The aim of this project was to assess the current evidence from longitudinal studies for childhood determinants of adult mental illness. Because of the variable and often prolonged period between factors in childhood and the identification of mental illness in adults, prospective studies, particularly birth cohorts, offer the best chance of demonstrating associations in individuals. A review was undertaken in 2006 of the published literature from longitudinal studies, together with some large-scale retrospective studies and relevant reviews which provided supplementary evidence. The main focus was upon potentially ameliorable characteristics, experiences or situations of childhood; however, other factors, not determinants but pre-cursors, associated with later mental illness could not be left out. Seven major electronic data-bases of published research were interrogated with a range of key-words and the results supplemented from personal searches, enquiries and reference trails. In excess of 1,500 abstracts were read to select 250 papers for full review. The material was assessed in relation to ten factors: Psychological disturbance; Genetic Influences; Neurological Deviance; Neuroticism; Behaviour; School Performance; Adversity; Child Abuse or Neglect; Parenting and parent-child relationships; Disrupted and Disfunctional Families. In 2011 the search was repeated for the period 2006 to mid-2011, using the same search terms and supplemented in the same manner. Over 1,800 abstracts emerged and almost 200 papers selected for more detailed review. These were then integrated into the original text with modifications where necessary. The whole text was then revised and edited in January / February 2012. There is continuing evidence for the association with later mental ill-health for each of these ten factors, but with different degrees of conviction. The evidence for each is discussed in detail and weighed both separately and in relation to others. These are then summarised, and the research implications are considered. Finally, the implications for prevention are discussed together with the practical potential for preventive and health-promoting programmes.

该项目的目的是评估目前的证据从纵向研究的儿童决定因素的成人精神疾病。由于儿童时期的因素与成人精神疾病的确定之间存在变数,而且往往需要很长时间,因此前瞻性研究,特别是出生队列研究,提供了证明个体之间关联的最佳机会。2006年对纵向研究的已发表文献进行了回顾,同时进行了一些大规模回顾性研究和提供补充证据的相关综述。主要的重点是儿童时期可能改善的特征、经历或情况;然而,与后期精神疾病相关的其他因素,不是决定因素,而是前兆,也不能被忽略。研究人员以一系列关键词查询七个主要的已发表研究的电子资料库,并以个人查册、查询和参考资料补充结果。阅读了1500多篇摘要,从中选出250篇论文进行全面审查。对材料进行了十个因素的评估:心理障碍;基因的影响;神经系统异常;神经质;行为;在学校的表现;逆境;虐待或忽视儿童;养育子女和亲子关系;破裂和不正常的家庭。2011年对2006年至2011年中期进行了重复搜索,使用了相同的搜索词,并以相同的方式进行了补充。超过1800篇摘要出现,近200篇论文被选中进行更详细的审查。然后将这些内容整合到原始文本中,并在必要时进行修改。全文随后在2012年1月/ 2月进行了修订和编辑。不断有证据表明,这十个因素中的每一个都与后来的精神疾病有关,但程度不同。对每一个证据都进行了详细的讨论,并分别进行了权衡,并将其与其他证据联系起来。然后对这些进行总结,并考虑研究的意义。最后,讨论了对预防的影响以及预防和促进健康方案的实际潜力。
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引用次数: 214
Are Psychiatric Diagnoses an Obstacle for Research and Practice? Reliability, Validity and the Problem of Psychiatric Diagnoses. The Case of GAD. 精神病诊断是研究和实践的障碍吗?精神病学诊断的信度、效度与问题。广泛性焦虑症。
Q2 Medicine Pub Date : 2012-01-01 Epub Date: 2012-02-24 DOI: 10.2174/1745017901208010012
Carlo Faravelli, Giovanni Castellini, Monica Landi, Andrea Brugnera

The present article focused on the problem of validity, reliability and specificity of psychiatric diagnoses.The authors moved by the concept of syndrome, defined by Sydenham in the 18th century as a constellation of several interrelated symptoms, showing a stable, characteristic structure and a peculiar prognosis, in order to analyse the peculiarity of the current psychiatric nosology. In our opinion, the current nosographic system based on DSM-IV criteria, prevents psychiatry from benefiting of the significant technological progress that has led the rest of medical sciences to important clinical achievements in the last 20 years. The case of Generalized Anxiety Disorder was taken as an example of a disease characterized by unstable diagnostic criteria, high rate of comorbidity and uncertain boundaries. An analysis of the data from the Sesto Fiorentino study was performed to investigate the presence of common mood and anxiety symptoms across the most represented DSM IV diagnoses, in order to evaluate the specificity of these symptoms.The results supported the hypothesis of a low specificity of these symptoms, suggesting the need for psychiatry to find new and more specific markers and instruments.

本文主要探讨精神病学诊断的效度、信度和特异性问题。18世纪,Sydenham将综合征的概念定义为几种相互关联的症状的集合,表现出稳定的特征结构和特殊的预后,为了分析当前精神病学的特殊性,作者受到了综合症概念的影响。在我们看来,目前基于DSM-IV标准的病科系统,阻碍了精神病学从重大的技术进步中获益,而在过去的20年里,其他医学科学取得了重要的临床成就。以广泛性焦虑障碍为例,诊断标准不稳定,合并率高,边界不确定。对Sesto Fiorentino研究的数据进行了分析,以调查最具代表性的DSM IV诊断中常见情绪和焦虑症状的存在,以评估这些症状的特异性。研究结果支持了这些症状特异性较低的假设,表明精神病学需要寻找新的、更特异性的标记物和工具。
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引用次数: 13
How Much is Geriatric Caregivers Burnout Caring-Specific? Questions from a Questionnaire Survey. 老年护理人员的职业倦怠有多严重?问卷调查中的问题。
Q2 Medicine Pub Date : 2010-07-29 DOI: 10.2174/1745017901006010066
Ennio Cocco

Summary:

Background and aims: Research dealing with occupational strain and burnout in geriatric care is generally focused on the behavioral problems of the patient and/or the psychological traits or attitudes of the carers rather than on organizational functionality. This paper describes data from a survey of all geriatric professions, using the Stressful Events Questionnaire (SEQ), a tool that takes into account multiple dimensions that can affect the genesis of burnout, including the patient, the geriatric health care professional, and the health care organization. The aim of this study is to compare patterns of answers among different roles in geriatric care.

Method: PATTERNS OF SEQ ANSWERS ARE DESCRIBED FOR THE ENTIRE SAMPLE AS WELL AS FOR WORKERS EXPERIENCING BURNOUT AND FOR EACH CARING PROFESSION INVESTIGATED: certified nursing assistants (CNAs), registered nurses and physicians/psychologists. RESULTS;: In general, carers refer more often as stressful the facility-related events; the only exception is that CNAs working in general hospital geriatric wards refer most often as stressful the patient-related events. The self-related events area seems to have a great importance for all professions.

Discussion: The specificity of gerontological burnout has to be discussed, to better define the role played by caring problems, including psychological attitudes of carers versus the role played by the institution and by the social situation of each worker. For CNAs, the interaction between educational background and the length of time spent as a CNA seems to be a critical topic.

背景和目的:关于老年护理中职业紧张和职业倦怠的研究通常集中在患者的行为问题和/或护理人员的心理特征或态度上,而不是组织功能上。本文使用压力事件问卷(SEQ)对所有老年职业进行了调查,该工具考虑了可能影响倦怠起源的多个维度,包括患者、老年医疗保健专业人员和医疗保健组织。本研究的目的是比较不同角色在老年护理中的回答模式。方法:对整个样本、经历过职业倦怠的工作者以及被调查的每个护理专业(注册护理助理、注册护士和医生/心理学家)的SEQ答案模式进行描述。结果:一般情况下,护理人员更常将与设施有关的事件称为压力;唯一的例外是,在综合医院老年病房工作的cna最常提到与患者有关的压力事件。与自己相关的活动似乎对所有职业都很重要。讨论:必须讨论老年倦怠的特殊性,以更好地定义照顾问题所起的作用,包括照顾者的心理态度与机构和每个工作者的社会状况所起的作用。对于CNA来说,教育背景和作为CNA的时间长短之间的相互作用似乎是一个关键的话题。
{"title":"How Much is Geriatric Caregivers Burnout Caring-Specific? Questions from a Questionnaire Survey.","authors":"Ennio Cocco","doi":"10.2174/1745017901006010066","DOIUrl":"https://doi.org/10.2174/1745017901006010066","url":null,"abstract":"<p><strong>Summary: </strong></p><p><strong>Background and aims: </strong>Research dealing with occupational strain and burnout in geriatric care is generally focused on the behavioral problems of the patient and/or the psychological traits or attitudes of the carers rather than on organizational functionality. This paper describes data from a survey of all geriatric professions, using the Stressful Events Questionnaire (SEQ), a tool that takes into account multiple dimensions that can affect the genesis of burnout, including the patient, the geriatric health care professional, and the health care organization. The aim of this study is to compare patterns of answers among different roles in geriatric care.</p><p><strong>Method: </strong>PATTERNS OF SEQ ANSWERS ARE DESCRIBED FOR THE ENTIRE SAMPLE AS WELL AS FOR WORKERS EXPERIENCING BURNOUT AND FOR EACH CARING PROFESSION INVESTIGATED: certified nursing assistants (CNAs), registered nurses and physicians/psychologists. RESULTS;: In general, carers refer more often as stressful the facility-related events; the only exception is that CNAs working in general hospital geriatric wards refer most often as stressful the patient-related events. The self-related events area seems to have a great importance for all professions.</p><p><strong>Discussion: </strong>The specificity of gerontological burnout has to be discussed, to better define the role played by caring problems, including psychological attitudes of carers versus the role played by the institution and by the social situation of each worker. For CNAs, the interaction between educational background and the length of time spent as a CNA seems to be a critical topic.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":" ","pages":"66-71"},"PeriodicalIF":0.0,"publicationDate":"2010-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1745017901006010066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40062676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Eating behaviour and body satisfaction in mediterranean children: the role of the parents. 地中海儿童的饮食行为和身体满意度:父母的作用。
Q2 Medicine Pub Date : 2010-07-20 DOI: 10.2174/1745017901006010059
Valdo Ricca, Francesco Rotella, Edoardo Mannucci, Claudia Ravaldi, Giovanni Castellini, Francesco Lapi, Linda Cangioli, Paolo Martini, Carlo Faravelli

Although the prevalence of fully expressed Eating Disorders is rare in young children, childhood eating disturbances are fairly common. Parents can play a facilitating role for the development of overweight and eating problems among their children. The aim of this study is to detect the possible relationships between children's eating attitudes and behaviour and the parents' beliefs about eating habits and body shape of their offspring.This survey was conducted in the area of Arezzo (Italy), on 900 children, aged 7-12, and on their parents/substitute caregivers. The Kids' Eating Disorder Survey questionnaire, and the CIBUS questionnaire were administered. A fully expressed Eating Disorder was diagnosed in two kids only. KEDS total score and weight/dissatisfaction subscale score positively correlated with parents' answers to the following CIBUS' items (How do you consider the body shape of your son/daughter? How much does your son/daughter eats? Have you ever thought of putting your son/daughter on a diet?). Positive correlations between the children BMI, desired BMI and the aforementioned CIBUS' items were found.The prevalence of formal Eating Disorders in children aged 7-12 is low. Children appear to be more preoccupied with their weight than with their body shape. Parents' beliefs about the offspring's body shape and eating habits have a relevant impact on children's eating attitudes and behaviour.

虽然完全表达的饮食失调在幼儿中很少见,但儿童饮食失调相当普遍。父母可以在孩子超重和饮食问题的发展中发挥促进作用。本研究的目的是检测儿童的饮食态度和行为与父母对子女的饮食习惯和体型的信念之间可能存在的关系。这项调查是在意大利阿雷佐地区进行的,调查对象是900名7-12岁的儿童及其父母/替代看护人。采用儿童饮食失调调查问卷和CIBUS问卷。只有两个孩子被诊断出患有完全表达的饮食失调症。KEDS总分和体重/不满意量表得分与父母对以下CIBUS项目(你如何看待你儿子/女儿的体型?你的儿子/女儿每天吃多少?你想过让你的儿子/女儿节食吗?儿童BMI、期望BMI与上述CIBUS项目呈正相关。7-12岁儿童的正式饮食失调患病率较低。孩子们似乎更关注自己的体重,而不是体型。父母对子女身材和饮食习惯的看法对子女的饮食态度和行为有相关的影响。
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引用次数: 11
Romantic attachment and subtypes/dimensions of jealousy. 浪漫依恋和嫉妒的亚型/维度。
Q2 Medicine Pub Date : 2010-07-08 DOI: 10.2174/1745017901006010053
Donatella Marazziti, Giorgio Consoli, Francesco Albanese, Emanuela Laquidara, Stefano Baroni, Mario Catena Dell'osso

The present study explored the possible relationship between romantic attachment and jealousy in 100 healthy subjects. The romantic attachment and jealousy were evaluated by means of, respectively, the "Experiences in Close Relationships" questionnaire (ECR), and the "Questionario della Gelosia" (QUEGE). The ECR anxiety scale was related to all QUEGE dimensions, while the ECR avoidance scale to three. Individuals with the preoccupied attachment style showed higher scores than secure subjects on the obsessionality, interpersonal sensitivity and fear of loss dimensions. Fearful-avoidant individuals had higher score than secure subjects on the fear of loss dimension only, while dismissing individuals had lower scores on the self-esteem dimension.These findings suggest that romantic attachment and jealousy are intertwined.

本研究以100名健康受试者为研究对象,探讨了浪漫依恋与嫉妒之间可能存在的关系。分别采用“亲密关系体验问卷”(ECR)和“亲密关系问卷”(QUEGE)对恋爱依恋和嫉妒进行评估。ECR焦虑量表与所有QUEGE维度相关,而ECR回避量表与三个维度相关。全神贯注依恋型个体在执著性、人际敏感性和恐惧损失维度上得分高于安全型个体。恐惧回避型个体仅在恐惧损失维度上的得分高于安全型个体,而拒绝型个体在自尊维度上的得分较低。这些发现表明,爱情依恋和嫉妒是交织在一起的。
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引用次数: 41
Depression, anxiety and alcohol abuse in a gastroenterology intensive care unit: prevalence and detection. 胃肠病重症监护病房的抑郁、焦虑和酗酒:患病率和检测。
Q2 Medicine Pub Date : 2010-07-08 DOI: 10.2174/1745017901006010047
Graça Cardoso, Joana Alexandre, Alda Rosa

Objectives: To assess depression, anxiety, and alcohol abuse in a Gastroenterology ICU, and the level of its detection by the staff.

Method: All patients consecutively admitted to the ICU during a six-month period, 18 or above, and staying ≥ 24 hours, were assessed with the Hospital Anxiety and Depression Scale (HADS) and the CAGE. Doctors and nurses assessed the type and severity of patients' morbidity. Data were analyzed with Student's t-test, Pearson's and Spearman's correlations for ordinal variables, chi-square for nominal variables, and multiple logistic regression.

Results: The 65 patients assessed had a mean age of 57, and were predominantly male (58.5%), married (72.3%), and retired (53.8%); 27.7% had a psychiatric history, 24.6% were on psychotropic drugs, and 32.3% had an alcohol intake above standards. Anxiety and depression HADS scores ≥ 8 were present in 29.2% and 35.4% of the patients, respectively; 20%, mainly men, scored positive on the CAGE. Women had significantly higher anxiety scores (=.012) than men but did not differ in depression. A psychiatric history was significantly associated with higher anxiety (p<.001) and depression (p=.007) scores, as well as being on psychotropic drugs regularly (p<.001; p=.03, respectively). Doctors diagnosed somatic illness in 48.8%, and somatic illness with psychiatric co-morbidity in 51%; for nurses the rates were, respectively, 41.5% and 58.6%. Doctors' and nurses' detection of psychiatric disorders were significantly associated with the HADS anxiety scores (p=.013; p=.001, respectively), and doctor's detection with depression (p=.046) scores. There were no significant associations between nurses' detection of psychiatric disorders and depression, and between both professional groups detection and alcohol abuse.

Conclusion: High prevalence of depression, anxiety, and alcohol abuse in Gastroenterology ICU was confirmed. However, the level of detection by the staff was low and mainly when anxiety symptoms were present.

目的:评估消化科ICU患者的抑郁、焦虑和酒精滥用,以及工作人员对其的检测水平。方法:采用医院焦虑抑郁量表(Hospital Anxiety and Depression Scale, HADS)和CAGE对所有连续6个月、18岁及以上、住院时间≥24小时的ICU患者进行评估。医生和护士评估患者发病的类型和严重程度。数据分析采用Student’st检验,有序变量采用Pearson’s和Spearman’s相关,名义变量采用卡方,多元逻辑回归。结果:65例患者平均年龄57岁,以男性(58.5%)、已婚(72.3%)、退休(53.8%)为主;27.7%有精神病史,24.6%服用精神药物,32.3%酒精摄入量高于标准。焦虑和抑郁HADS评分≥8分的患者分别占29.2%和35.4%;20%的人(主要是男性)的CAGE得分为阳性。女性的焦虑得分明显高于男性(= 0.012),但在抑郁方面没有差异。精神病史与高焦虑显著相关(p结论:证实了消化内科ICU患者抑郁、焦虑和酗酒的高发。然而,工作人员的检测水平很低,主要是在出现焦虑症状时。
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引用次数: 9
Draft for Clinical Practice and Epidemiology in Mental Health Neurobiological Alterations Induced by Exercise and Their Impact on Depressive Disorders 运动引起的神经生物学改变及其对抑郁症的影响
Q2 Medicine Pub Date : 2010-01-01 DOI: 10.2174/17450179010060100115
I. Helmich, A. Latini, A. Sigwalt, M. Carta, S. Machado, B. Velasques, P. Ribeiro, H. Budde
Background: The impact of physical activity on brain metabolic functions has been investigated in different studies and there is growing evidence that exercise can be used as a preventive and rehabilitative intervention in the treat- ment of depressive disorders. However, the exact neuronal mechanisms underlying the latter phenomenon have not been clearly elucidated. The present article summarises key results derived from studies that focussed on the neurobiological impact of exercise on brain metabolic functions associated with depressive disorders. Since major depressive disorder (MDD) is a life threatening disease it is of great significance to find reliable strategies to prevent or to cure this illness. Therefore, the aim of this paper is to review (1) the physiological relationship between physical activity and depressive disorders and (2) the potential neurobiological alterations induced by exercise that might lead to the relief of mental disor- ders like depression. Methods: We searched electronic databases for literature concerning the relationship between exercise and depression from 1963 until 2009. Results: The data suggests an association between physical inactivity and higher levels of depressive symptoms. Properly designed studies could show that exercise training can be as effective as antidepressive medications. Conclusion: The exact mechanisms how exercise affects the brain are not fully understood and the literature lacks of well designed studies concerning the effects of exercise training on depressive disorders. But the observed antidepressant ac- tions of exercise are strong enough that it already can be used as an alternative to current medications in the treatment of depressive disorders.
背景:体育活动对大脑代谢功能的影响已经在不同的研究中进行了调查,越来越多的证据表明,运动可以作为抑郁症治疗的预防和康复干预措施。然而,后一种现象背后的确切神经机制尚未清楚阐明。本文总结了运动对与抑郁症相关的脑代谢功能的神经生物学影响的主要研究结果。由于重度抑郁症(MDD)是一种危及生命的疾病,寻找可靠的策略来预防或治疗这种疾病具有重要意义。因此,本文的目的是回顾(1)体育活动与抑郁症之间的生理关系,(2)运动引起的潜在神经生物学改变可能导致抑郁症等精神障碍的缓解。方法:检索电子数据库中1963年至2009年间有关运动与抑郁关系的文献。结果:数据表明缺乏身体活动与较高程度的抑郁症状之间存在关联。适当设计的研究可以表明,运动训练可以和抗抑郁药物一样有效。结论:运动如何影响大脑的确切机制尚不完全清楚,文献中缺乏关于运动训练对抑郁症影响的精心设计的研究。但是,观察到的运动的抗抑郁作用已经足够强大,它已经可以作为治疗抑郁症的替代药物。
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引用次数: 12
Improving physical quality of life with group physical activity in the adjunctive treatment of major depressive disorder. 团体体育活动在重度抑郁症辅助治疗中改善身体生活质量。
Q2 Medicine Pub Date : 2008-01-26 DOI: 10.1186/1745-0179-4-1
Mauro Giovanni Carta, Maria Carolina Hardoy, Alessandra Pilu, Manlio Sorba, Anna Laura Floris, Francesca Ada Mannu, Antonia Baum, Alessandra Cappai, Claudio Velluti, Massimiliano Salvi

Background: The aim of the study was to compare the change in quality of life over 32 weeks in depressed women assuming antidepressant drug with (experimental group) or without (control group) physical exercise from a study which results on objective dimension of outcome were already published.

Methods: Trial with randomized naturalistic control. Patients selected from the clinical activity registries of a Psychiatric University Unit.

Inclusion criteria: female, between 40 and 60 years, diagnosis of Major Depressive Disorders (MMD, DSM-IV TR) resistant to ongoing treatment.

Exclusion criteria: diagnosis of psychotic disorders; any contraindications to physical activity. 30 patients (71.4% of the eligible) participated to the study.

Cases: 10 randomized patients undergoing pharmacological treatment plus physical activity.

Controls: 20 patients undergoing only pharmacological therapy. Quality of life was measured by means of WHOQOL-Bref.

Results: The patients that made physical activity had their WHOQOL-Bref physical score improved from T0 to T8, the differences was statistically significant. In the control group WHOQOL-Bref physical remains the same and, consequentially, the difference between T0 and T8 do not reach any statistical significance.The perceived quality of life in the other domains did not change during the treatment in both groups. Thus no other differences were found between and within groups.

Discussion and conclusion: The data presented in the previous paper found that physical activity seems a good adjunctive treatment in the long term management of patients with MDD. These new data indicated that physical activity may also improve the perceived physical quality of life. The dimensions related with social functioning, environment and psychical well being seem do not improved, unexpectedly, during the trial. Two objective dimension not strictly related to the depressive symptoms improved: social functioning and Clinical Global Impression, this discrepancy with a subjective and objective dimension of the well being may supported the Goldberg point of view that subjective quality of life in bipolar and unipolar severe depression patients may not accurately reflect objective functional outcome status, potentially due to diminished insight, demoralization, or altered life expectations over time. It may be that physical activity improve the self perception of physical well being. The physical domains of WHOQOL-Bref inquiry about conditions as sleep, pain, energy, body satisfaction that seems frequently problematic also in remission due to the pharmacotherapy and may be risk factor for relapse/recurrence. Thus physical therapy seems to determinate improvement in depressive aspects not frequently responsive to the drug treatment.

背景:本研究的目的是比较服用抗抑郁药物(实验组)和不进行体育锻炼(对照组)的抑郁症妇女在32周内生活质量的变化,该研究结果的客观维度已经发表。方法:随机自然对照试验。从精神科大学的临床活动登记处挑选的患者。纳入标准:女性,年龄在40 - 60岁之间,诊断为对持续治疗有抵抗力的重度抑郁症(MMD, DSM-IV TR)。排除标准:诊断为精神障碍;身体活动的禁忌症。30例患者(71.4%)参加了研究。病例:随机选取10例患者,接受药物治疗加体育锻炼。对照组:20例患者仅接受药物治疗。采用WHOQOL-Bref量表测定生活质量。结果:进行体力活动的患者WHOQOL-Bref体力评分由T0提高至T8,差异有统计学意义。对照组WHOQOL-Bref physical不变,因此T0与T8之间的差异无统计学意义。在治疗期间,两组在其他领域的感知生活质量没有改变。因此,各组之间和组内没有发现其他差异。讨论与结论:先前论文的数据显示,体育锻炼似乎是长期治疗重度抑郁症患者的一种很好的辅助治疗方法。这些新数据表明,体育活动也可能改善人们对生活质量的感知。出乎意料的是,在试验期间,与社会功能、环境和心理健康相关的维度似乎没有得到改善。两个与抑郁症状没有严格关系的客观维度:社会功能和临床整体印象,这种与幸福感的主观和客观维度的差异可能支持Goldberg的观点,即双相和单相严重抑郁症患者的主观生活质量可能不能准确反映客观功能结果状态,这可能是由于随着时间的推移洞察力下降、士气低落或生活期望改变所致。可能是体育活动提高了身体健康的自我感知。whoqol - brief查询的身体领域,如睡眠、疼痛、能量、身体满意度等似乎经常出现问题的情况,也因药物治疗而缓解,可能是复发/复发的危险因素。因此,物理治疗似乎决定了抑郁方面的改善,而不经常对药物治疗有反应。
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引用次数: 121
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Clinical Practice and Epidemiology in Mental Health
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