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Delphi Survey of Items for the Test of Stuttering Screening in Children (TSSC). 儿童口吃筛查项目的德尔菲调查(TSSC)。
Q2 Medicine Pub Date : 2023-07-26 eCollection Date: 2023-01-01 DOI: 10.2174/17450179-v19-230615-2022-27
Aiswarya Liz Varghese, Radish Kumar Balasubramanium, Gagan Bajaj, Sudhin Karuppali, Unnikrishnan Bhaskaran

Purpose: Stuttering is a fluency disorder that mostly begins in childhood and affects many people in our societies. No standardized screening tools are available to check for stuttering in the Indian school-going population. Thus, the study aimed at developing a screening tool to identify children who stutter among the school-going population using a Delphi-based approach.

Methods: This study was carried out in four phases. During the first phase, five Speech Language Pathologists (SLPs) were asked about the need for screening and the nature & attributes of a stuttering screening test for school-going children. The second phase involved constructing appropriate stimuli for the screening tool based on expert opinion, relevant literature and students' academic textbooks. The third phase involved content validation of the speech elicitation stimuli by four teachers, five SLPs and an English Lecturer teaching in a university. The fourth phase encompassed the development of differential diagnosis criteria for stuttering identification in children using a rank analysis of the expert opinions.

Results: A stuttering screening stimuli comprising age, language and culture-specific reading, picture description and narration tasks for 1st to 10th-standard students was developed. The contents of the tool obtained satisfactory consensus of agreement among the panel of experts. Further, the tool outlined five critical diagnostic criteria which could differentially diagnose school-going children with stuttering from typically speaking counterparts using the developed material.

Conclusion: The developed screening tool could help practicing clinicians quickly identify stuttering in school-going populations. This would enable early identification and build up the statistical data to estimate the prevalence of stuttering among the school-going population. Further studies examining the psychometric properties of the developed test are in progress.

目的:口吃是一种流利性障碍,主要始于儿童时期,影响着我们社会中的许多人。目前还没有标准化的筛查工具来检查印度在校人群的口吃情况。因此,该研究旨在开发一种筛查工具,使用基于德尔菲的方法在在校人群中识别口吃儿童。方法:本研究分四个阶段进行。在第一阶段,五名言语语言病理学家(SLP)被问及筛查的必要性以及针对在校儿童的口吃筛查测试的性质和特点。第二阶段涉及根据专家意见、相关文献和学生的学术教科书为筛选工具构建适当的刺激因素。第三阶段涉及四名教师、五名SLP和一名大学英语讲师对言语启发刺激的内容验证。第四阶段包括使用专家意见的等级分析来制定儿童口吃识别的鉴别诊断标准。结果:为1至10年级标准学生开发了包括年龄、语言和文化特定阅读、图片描述和叙述任务的口吃筛查刺激。该工具的内容在专家小组中获得了令人满意的一致意见。此外,该工具概述了五个关键的诊断标准,这些标准可以使用开发的材料对上学的口吃儿童与说话正常的儿童进行区别诊断。结论:开发的筛查工具可以帮助临床医生快速识别在校人群中的口吃。这将有助于早期识别并建立统计数据,以估计在校人群中口吃的患病率。对所开发测试的心理测量特性的进一步研究正在进行中。
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引用次数: 0
Physical Activity Reduces Depression among Healthcare Workers during the COVID-19 Pandemic in Jordan. 在约旦新冠肺炎大流行期间,体育活动减少了医护人员的抑郁症。
Q2 Medicine Pub Date : 2023-07-25 eCollection Date: 2023-01-01 DOI: 10.2174/17450179-v19-230720-2023-8
Abdulhakeem Okour, Basil Amarneh

Aims: This study aimed to assess mental health status by measuring depression and investigating the effect of physical activity in lessening the mental health burden among HCWs during the COVID-19 pandemic in Jordan.

Background: The COVID-19 pandemic has caused distress and depression among healthcare workers and drastic disruptions in social, economic, and health systems worldwide.

Methods: A cross-sectional online study through google forms involved HCWs across Jordan for two months. The 10-item short form of the Center for Epidemiological Studies Depression Scale Revised (CESD-R10) was used to assess depressive symptoms.

Results: The total sample was 295, females were 50.5% with mean age of 33.1 (>80% less than 40 years old), married 51.9%, 63% were physicians, 88.1% had contact with patients, and 64.7% were smokers. Depression symptoms were perceived by 59.3% of the total samples (53.1).

Conclusion: During the COVID-19-induced nationwide lockdown in Jordan, HCWs who engaged in enough physical exercise reported fewer depressive symptoms. Promoting physical exercise among HCWs may lead to better results for their mental health. Various clinical implications support promoting designated time and space for physical activity at work.

目的:本研究旨在通过测量抑郁情绪来评估心理健康状况,并调查在约旦新冠肺炎大流行期间,体育活动在减轻HCW心理健康负担方面的作用。背景:新冠肺炎大流行已在全世界医护人员中造成痛苦和抑郁,并严重破坏了社会、经济和卫生系统。方法:一项通过谷歌表格进行的横断面在线研究涉及约旦各地的HCW,为期两个月。流行病学研究中心抑郁量表修订版(CESD-R10)的10项简表用于评估抑郁症状。结果:总样本为295人,女性占50.5%,平均年龄33.1岁(>80%小于40岁),已婚51.9%,63%为医生,88.1%与患者有过接触,64.7%为吸烟者。59.3%的样本(53.1)感知到抑郁症状。结论:在新冠肺炎引发的约旦全国封锁期间,参加足够体育锻炼的医务人员报告的抑郁症状较少。在HCW中促进体育锻炼可以为他们的心理健康带来更好的结果。各种临床意义支持促进指定的时间和空间在工作中进行体育活动。
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引用次数: 0
Vaccination as a Significant Factor Influencing the Psychoemotional State of Medical Students During the Sars-Cov-2 Pandemic: An International Aspect. 在新冠肺炎疫情期间,疫苗接种是影响医学生心理情绪状态的重要因素:一个国际方面。
Q2 Medicine Pub Date : 2023-07-11 eCollection Date: 2023-01-01 DOI: 10.2174/1745-0179-v19-e230420-2022-49
Maria V Sankova, Vladimir N Nikolenko, Tatiana M Litvinova, Beatrice A Volel, Marina V Oganesyan, Andjela D Vovkogon, Negoria A Rizaeva, Sergey V Sankov, Mikhail Y Sinelnikov

Background: The rapid spread of SARS-COV-2, characterized by its severe course in the absence of effective specific treatment for this infection, may become a significant risk factor for psycho-emotional disorders' emergence during this pandemic. One of the vulnerable groups in the current situation are first-year medical students, whose problems associated with an unfavorable sanitary-epidemiological situation and an increased infection risk are compounded by the difficulties of adapting to specific professional environments. In this situation, along with strict adherence to nonspecific prevention methods, the mass student SARS-COV-2 vaccination acquires particular importance.

Objective: To compare the attitudes of first-year medical students in Russia and Azerbaijan toward SARS-COV-2 immunization and to assess the vaccination impact on the student's psycho-emotional state during the SARS-COV-2 pandemic.

Materials and methods: The study involved 594 first-year students at the Moscow and Baku branches of Sechenov University. The Google Forms platform was used to conduct an anonymous sociological survey. To compare the psychoemotional state of vaccinated freshmen and non-vaccinated students, we used the State-Trait Anxiety Inventory, STAI, to assess reactive anxiety and the Beck Depression Inventory test - to diagnose depressive symptoms. The online survey was conducted during the fourth wave of coronavirus infection. WHO official sources were used to analyze the current epidemiological SARS-COV-2 situation during the study data provided by the Russian Federal Service on Customers' Rights Protection and Human Well-Being Surveillance and JHU CSSE. Statistical analysis was carried out using RStudio.

Results: The study results showed that vaccination coverage of first-year students at the Moscow branch of Sechenov University during the fourth wave of the SARS-COV-2 pandemic was 42,9±5,13%, at the Baku branch - 69,6±5,86%. The lack of reliable information about anticovid vaccines, indicated by a third of all respondents, may largely determine the motivated participation in the vaccination SARS-COV-2 campaign. The role of medical school in imparting knowledge about active SARS-COV-2 immunization to medical students was found to be insignificant. It was shown that the percentage of students willing to recommend SARS-COV-2 vaccination to the people around them and thereby contribute to increasing collective immunity level significantly depends on the percentage of students vaccinated. It was proved that vaccinated students were characterized by significantly greater psychological stability regardless of their study place.

Conclusion: Vaccination is not only a good preventive measure against the infection spread but also a significant factor in stabilizing the psycho-emotional state of first-year students, which significantly affects the quality

背景:严重急性呼吸系统综合征冠状病毒2型的快速传播,其特点是在缺乏有效的特异性治疗的情况下,其病程严重,可能成为此次疫情期间出现心理情绪障碍的一个重要风险因素。目前情况下的弱势群体之一是一年级的医学生,他们的问题与不利的卫生流行病学状况和感染风险增加有关,再加上难以适应特定的专业环境。在这种情况下,随着严格遵守非特异性预防方法,大规模学生接种严重急性呼吸系统综合征冠状病毒2型疫苗变得尤为重要。目的:比较俄罗斯和阿塞拜疆医学院一年级学生对严重急性呼吸系统综合征冠状病毒2型疫苗接种的态度,并评估疫苗接种对严重急性呼吸道综合征病毒2型疫情期间学生心理情绪状态的影响。材料和方法:这项研究涉及谢切诺夫大学莫斯科和巴库分校的594名一年级学生。谷歌表单平台被用来进行一项匿名的社会学调查。为了比较接种疫苗的新生和未接种疫苗的学生的心理情绪状态,我们使用状态-特质焦虑量表(STAI)来评估反应性焦虑,并使用贝克抑郁量表测试来诊断抑郁症状。这项在线调查是在第四波冠状病毒感染期间进行的。在俄罗斯联邦客户权利保护和人类健康监测服务局和JHU CSSE提供的研究数据中,使用世界卫生组织官方来源分析了目前SARS-COV-2的流行病学状况。使用RStudio进行统计分析。结果:研究结果显示,在第四波严重急性呼吸系统综合征冠状病毒2型疫情期间,谢切诺夫大学莫斯科分校一年级学生的疫苗接种覆盖率为42,9±5,13%,巴库分校为69,6±5,86%。三分之一的受访者表示,缺乏有关抗冠状病毒疫苗的可靠信息,这可能在很大程度上决定了是否有动机参与接种严重急性呼吸系统综合征冠状病毒2型疫苗。医学院在向医学生传授积极的严重急性呼吸系统综合征冠状病毒2型免疫知识方面的作用被发现是微不足道的。研究表明,愿意向周围人推荐接种严重急性呼吸系统综合征冠状病毒2型疫苗从而有助于提高集体免疫水平的学生比例在很大程度上取决于接种疫苗的学生比例。事实证明,接种疫苗的学生无论在哪里学习,都具有显著更大的心理稳定性。结论:接种疫苗不仅是预防感染传播的良好措施,也是稳定一年级学生心理情绪状态的重要因素,对其教育过程的质量和有效性有重要影响。
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引用次数: 0
Association between Proinflammatory Cytokines and Anxiety and Depression Symptoms in Rheumatoid Arthritis Patients: A Cross-sectional Study. 类风湿性关节炎患者的促炎细胞因子与焦虑和抑郁症状之间的关系:一项横断面研究。
Q2 Medicine Pub Date : 2023-06-22 eCollection Date: 2023-01-01 DOI: 10.2174/17450179-v19-e230510-2022-34
Faisal Parlindungan, Rudy Hidayat, Anna Ariane, Hamzah Shatri

Background: Rheumatoid arthritis (RA) patients have a greater prevalence of anxiety and depression. Proinflammatory cytokines are elevated in RA. We aim to evaluate the association between systemic inflammation in RA and anxiety and depression.

Methods: There were 31 RA patients, 16 with active disease activity and 15 in remission state; they were assessed using the Hospital Anxiety and Depression Scale and for RA disease activity using Disease Activity Score of 28 joints (DAS28) - CRP (C-reactive protein). Serum proinflammatory cytokines were measured, including interleukin (IL)-6, IL-17, and Tumour Necrosis Factor-alpha (TNF-α).

Results: Among 31 patients, ten patients showed anxiety symptoms, 19 patients showed depression symptoms, and two displayed mixed symptoms. Serum TNF-α levels were significantly higher in active disease than in the remission group (p-value 0.006). There was no association or correlation between proinflammatory cytokines to anxiety and depression symptoms in the active disease and remission groups.

Conclusion: This suggests that other factors besides disease activity and state of systemic inflammation may cause anxiety and depression in RA patients.

背景:类风湿性关节炎(RA)患者焦虑和抑郁的患病率较高。RA患者的炎性细胞因子升高。我们的目的是评估RA的全身炎症与焦虑和抑郁之间的关系。方法:RA患者31例,活动期16例,缓解期15例;他们使用医院焦虑和抑郁量表进行评估,并使用28关节疾病活动评分(DAS28)-CRP(C反应蛋白)进行RA疾病活动评估。结果:31例患者中,10例出现焦虑症状,19例出现抑郁症状,2例出现混合症状。活动性疾病患者血清TNF-α水平显著高于缓解组(p值0.006)。活动性疾病组和缓解组的促炎细胞因子与焦虑和抑郁症状之间没有关联或相关性。结论:RA患者除疾病活动和全身炎症状态外,还可能存在其他因素引起焦虑和抑郁。
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引用次数: 0
Mental Health: Pandemics, Epidemics and Tau Protein. 心理健康:流行病、流行病和Tau蛋白。
Q2 Medicine Pub Date : 2023-06-21 eCollection Date: 2023-01-01 DOI: 10.2174/17450179-v19-e230510-2022-51
Ghinwa M Barakat, Ghaith Assi, Noura B El Khoury

Background: It is well established that a wide range of psychological disorders are influenced by the way people live, with lifestyle-related factors playing a substantial role. During the past decade, the effects of major disasters on mental health have drawn a lot of attention.

Aim: In this review, we compare clinical studies reporting a link between COVID-19 and other pandemics and mental health. Importantly, we also shed light on Tau protein and neurotransmitters as neurobiological factors that might explain this link.

Methods: A thorough PubMed search was done to gather and summarize published data on the COVID-19 pandemic's effect on mental health. Additionally, these studies were compared to previous research published on PubMed, triggering other pandemic and epidemic impacts on mental health.

Results: The COVID-19 epidemic has had the biggest impact on raising awareness about mental health. Moreover, the past century has seen an increase in the frequency of disease outbreaks like MERS-CoV, Ebola, and Influenza, which all had an impact on mental health. However, the exact role of these epidemics on mental health and brain functions is poorly understood.

Conclusion: Future research on the underlying pathways may yield essential information for the treatment and prevention of prospective mental diseases in light of the ongoing decline in mental health during the past 10 years.

背景:众所周知,人们的生活方式会影响各种各样的心理障碍,与生活方式相关的因素在其中发挥着重要作用。在过去的十年里,重大灾难对心理健康的影响引起了人们的广泛关注。目的:在这篇综述中,我们比较了报告新冠肺炎与其他流行病和心理健康之间联系的临床研究。重要的是,我们还阐明了Tau蛋白和神经递质作为可能解释这种联系的神经生物学因素。方法:通过PubMed全面检索,收集和总结已发表的关于新冠肺炎大流行对心理健康影响的数据。此外,这些研究与之前发表在PubMed上的研究进行了比较,引发了其他大流行和流行病对心理健康的影响。结果:新冠肺炎疫情对提高心理健康意识的影响最大。此外,在过去的一个世纪里,MERS-CoV、埃博拉和流感等疾病爆发的频率有所增加,这些都对心理健康产生了影响。然而,人们对这些流行病对心理健康和大脑功能的确切作用知之甚少。结论:鉴于过去10年来心理健康的持续下降,未来对潜在途径的研究可能会为治疗和预防前瞻性心理疾病提供重要信息。
{"title":"Mental Health: Pandemics, Epidemics and Tau Protein.","authors":"Ghinwa M Barakat,&nbsp;Ghaith Assi,&nbsp;Noura B El Khoury","doi":"10.2174/17450179-v19-e230510-2022-51","DOIUrl":"https://doi.org/10.2174/17450179-v19-e230510-2022-51","url":null,"abstract":"<p><strong>Background: </strong>It is well established that a wide range of psychological disorders are influenced by the way people live, with lifestyle-related factors playing a substantial role. During the past decade, the effects of major disasters on mental health have drawn a lot of attention.</p><p><strong>Aim: </strong>In this review, we compare clinical studies reporting a link between COVID-19 and other pandemics and mental health. Importantly, we also shed light on Tau protein and neurotransmitters as neurobiological factors that might explain this link.</p><p><strong>Methods: </strong>A thorough PubMed search was done to gather and summarize published data on the COVID-19 pandemic's effect on mental health. Additionally, these studies were compared to previous research published on PubMed, triggering other pandemic and epidemic impacts on mental health.</p><p><strong>Results: </strong>The COVID-19 epidemic has had the biggest impact on raising awareness about mental health. Moreover, the past century has seen an increase in the frequency of disease outbreaks like MERS-CoV, Ebola, and Influenza, which all had an impact on mental health. However, the exact role of these epidemics on mental health and brain functions is poorly understood.</p><p><strong>Conclusion: </strong>Future research on the underlying pathways may yield essential information for the treatment and prevention of prospective mental diseases in light of the ongoing decline in mental health during the past 10 years.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"19 ","pages":"e174501792305020"},"PeriodicalIF":0.0,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71427516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quality of Life of Mothers and Fathers of Children with Autism Spectrum Disorder in Jordan. 约旦自闭症谱系障碍儿童父母的生活质量。
Q2 Medicine Pub Date : 2023-06-05 eCollection Date: 2023-01-01 DOI: 10.2174/17450179-v19-e230529-2022-40
Eiman A Ahmed, Sireen M Alkhaldi, Hamza Alduraidi, Rania A Albsoul, Mohammad Z Alhamdan

Background: Parenting children with autism spectrum disorder (ASD) is widely identified to be associated with life-long impairment in parents' quality of life (QoL). However, there has been little information on the QoL of parents of children with ASD in the Jordanian context.

Objective: This study aimed to assess the QoL among mothers and fathers who have children with ASD in Jordan and to identify factors associated with it.

Methods: In this cross-sectional study, respondents were mothers and fathers of children with ASD attending autism rehabilitation centers in Amman. Data were collected from 206 participants using a validated questionnaire. Descriptive statistics, T-test, ANOVA and logistic regression, were applied.

Results: Overall quality of life was low (mean= 2.32). The physical dimension scored the highest (mean =2.79), and the environmental dimension scored the lowest (mean= 2.06). Results indicated that fathers and parents with low education reported significantly lower QoL scores (p = .024 and 0.001, respectively).

Conclusion: Among parents of children with ASD, parents at risk for low QoL were recognized. Our results can be utilized to design interventions to support mothers and fathers at risk in Jordan to enhance their QoL.

背景:自闭症谱系障碍(ASD)患儿的父母关系被广泛认为与父母生活质量(QoL)的终身损害有关。然而,在约旦,关于自闭症谱系障碍儿童父母的生活质量的信息很少。目的:本研究旨在评估约旦有自闭症谱系障碍儿童的父母的生活质量,并确定与之相关的因素。使用经验证的问卷从206名参与者中收集数据。采用描述性统计、T检验、方差分析和逻辑回归。结果:总体生活质量较低(平均值=2.32)。身体维度得分最高(平均值2.79),环境维度得分最低(平均值2.06)。结果表明,受教育程度低的父亲和父母的生活质量得分显著较低(分别为p=0.024和0.001)。结论:在ASD儿童的父母中,有低生活质量风险的父母得到了认可。我们的研究结果可用于设计干预措施,支持约旦面临风险的母亲和父亲,以提高他们的生活质量。
{"title":"Quality of Life of Mothers and Fathers of Children with Autism Spectrum Disorder in Jordan.","authors":"Eiman A Ahmed, Sireen M Alkhaldi, Hamza Alduraidi, Rania A Albsoul, Mohammad Z Alhamdan","doi":"10.2174/17450179-v19-e230529-2022-40","DOIUrl":"10.2174/17450179-v19-e230529-2022-40","url":null,"abstract":"<p><strong>Background: </strong>Parenting children with autism spectrum disorder (ASD) is widely identified to be associated with life-long impairment in parents' quality of life (QoL). However, there has been little information on the QoL of parents of children with ASD in the Jordanian context.</p><p><strong>Objective: </strong>This study aimed to assess the QoL among mothers and fathers who have children with ASD in Jordan and to identify factors associated with it.</p><p><strong>Methods: </strong>In this cross-sectional study, respondents were mothers and fathers of children with ASD attending autism rehabilitation centers in Amman. Data were collected from 206 participants using a validated questionnaire. Descriptive statistics, T-test, ANOVA and logistic regression, were applied.</p><p><strong>Results: </strong>Overall quality of life was low (mean= 2.32). The physical dimension scored the highest (mean =2.79), and the environmental dimension scored the lowest (mean= 2.06). Results indicated that fathers and parents with low education reported significantly lower QoL scores (p = .024 and 0.001, respectively).</p><p><strong>Conclusion: </strong>Among parents of children with ASD, parents at risk for low QoL were recognized. Our results can be utilized to design interventions to support mothers and fathers at risk in Jordan to enhance their QoL.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":"19 ","pages":"e174501792304180"},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71427518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of COVID-19 Confinement on Reading Behavior. 新冠肺炎隔离对阅读行为的影响。
Q2 Medicine Pub Date : 2023-06-05 eCollection Date: 2023-01-01 DOI: 10.2174/17450179-v19-e230505-2022-42
Mahmoud A Alomari, Omar F Khabour, Karem H Alzoubi, Aseel Aburub

Background: The COVID-19 pandemic was detrimental to lifestyle and behavior. In this investigation, changes in reading habits during the pandemic were examined.

Methods: The study is cross-sectional and survey-based. 1844 individuals completed an online survey about sociodemographic and reading habits during COVID-19. Multinomial logistic regression was used to examine the relationship between the study variables.

Results: Most of the participants were active readers (71.5%-83.2%). Fewer (13.8-18.0%) reported a decrease in reading, while about half reported a no change, and 1/3rd reported an increase. Changes in reading habits were related to age, education, job type, and income.

Conclusion: About half of the participants during the pandemic reported a change in reading habits. Interventions to further enhance reading among people during the pandemic might help ameliorate the negative impacts of the pandemic.

背景:新冠肺炎大流行对生活方式和行为有害。在这项调查中,研究了疫情期间阅读习惯的变化。方法:本研究采用横断面调查法。1844人完成了一项关于新冠肺炎期间社会人口统计和阅读习惯的在线调查。多元逻辑回归用于检验研究变量之间的关系。结果:大多数参与者都是活跃的读者(71.5%-83.2%)。很少有人(13.8-18.0%)报告阅读量下降,而大约一半的人报告没有变化,三分之一的人报告阅读量增加。阅读习惯的变化与年龄、教育程度、工作类型和收入有关。结论:在疫情期间,大约一半的参与者报告说阅读习惯发生了变化。在疫情期间进一步提高人们阅读能力的干预措施可能有助于减轻疫情的负面影响。
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引用次数: 2
Is a Genetic Variant associated with Bipolar Disorder Frequent in People without Bipolar Disorder but with Characteristics of Hyperactivity and Novelty Seeking? 与双相情感障碍相关的基因变异在没有双相情感疾病但具有过度活跃和求新特征的人中是否频繁?
Q2 Medicine Pub Date : 2023-05-15 eCollection Date: 2023-01-01 DOI: 10.2174/17450179-v19-e230419-2022-53
Goce Kalcev, Alessandra Scano, Germano Orrù, Diego Primavera, Giulia Cossu, Antonio Egidio Nardi, Mauro Giovanni Carta

Objective: The objective is to verify whether a genetic condition associated with bipolar disorder (BD) is frequent in old adults adapted to their environment, without BD, but with aptitudes for hyperactivity and novelty seeking (H/NS).

Methods: In this cross-sectional study, the study sample included healthy elderly people (40 participants, aged 60 or older) living in an urban area and recruited from a previous study on physical exercise and active aging, who were compared with 21 old adults with BD from the same area. The genetic methodology consisted of blood sampling, DNA extraction, real-time PCR jointly with FRET probes, and the SANGER sequencing method. The genetic variant RS1006737 of CACNA1C, found to be associated with bipolar disorder diagnosis, was investigated.

Results: The frequency of the RS1006737 genetic variant in the study group (H/NS) is not higher than in the BD group and is statistically significantly higher than in all the control groups found in the literature. However, the familiarity for BD is higher in old adults with BD than in the H/NS sample without BD. The risk of BD in the family (also considering those without BD but with family members with BD) is not associated with the presence of the genetic variant examined.

Conclusion: The study suggests that the gene examined is associated with characteristics of hyperactivity rather than just BD. Nevertheless, choosing to participate in an exercise program is an excessively general way to identify H/NS. The next step would be to identify the old adults with well-defined H/NS features with an adequate tool.

目的:目的是验证与双相情感障碍(BD)相关的遗传状况是否在适应环境、没有BD但具有多动和寻求新奇能力(H/NS)的老年人中频繁发生。方法:在这项横断面研究中,研究样本包括居住在城市地区的健康老年人(40名参与者,年龄在60岁或以上),他们是从之前关于体育锻炼和主动衰老的研究中招募的,并与来自同一地区的21名患有BD的老年人进行了比较。遗传方法包括血液采样、DNA提取、实时PCR与FRET探针联合以及SANGER测序方法。研究发现CACNA1C的遗传变异RS1006737与双相情感障碍的诊断有关。结果:研究组RS1006737基因变异的频率(H/NS)不高于BD组,并且在统计学上显著高于文献中发现的所有对照组。然而,患有BD的老年人对BD的熟悉程度高于没有BD的H/NS样本。家庭中患BD的风险(也考虑到那些没有BD但有BD家庭成员的人)与所检查的遗传变异的存在无关。结论:研究表明,所检测的基因与多动特征有关,而不仅仅是BD。然而,选择参加锻炼项目是识别H/NS的一种过于普遍的方法。下一步是用适当的工具识别具有明确的H/NS特征的老年人。
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引用次数: 5
Effectiveness of Mindfulness-acceptance-commitment based approach for Rumination, Cognitive Flexibility and Sports Performance of Elite Players of Beach Soccer: A Randomized Controlled Trial with 2-months Follow-up. 基于正念接受承诺的方法对沙滩足球精英球员反刍、认知灵活性和运动表现的有效性:一项为期两个月的随机对照试验。
Q2 Medicine Pub Date : 2023-05-12 eCollection Date: 2023-01-01 DOI: 10.2174/17450179-v19-e230419-2022-33
Fatemeh Sabzevari, Hossein Samadi, Farahnaz Ayatizadeh, Sergio Machado

Background/objective: There is little research on the effectiveness of new approaches to psychology, including mindfulness-acceptance-commitment, especially in team disciplines. Therefore, this study compared mindfulness-acceptance and commitment-based approaches to rumination, cognitive flexibility, and sports performance of elite beach soccer players during a two-month follow-up.

Methods: The research design consisted of a randomized controlled trial (RCT), with follow-up. Thus, 34 players of the premier league of beach soccer were randomly divided into intervention and control groups based on mindfulness acceptance and commitment. The experimental group exercises consisted of one session per week for 7 weeks and daily homework. Participants filled out the questionnaires of the Ruminative Response Scale, Cognitive Flexibility Inventory, and Sports Performance Questionnaire before, after, and at two months of follow-up of the intervention.

Results: Multivariate Analysis of Variance (MANOVA) and Analysis of Variance (ANOVA) with repeated measures were used to evaluate the changes over time and compare the scores of the subjects of the two groups. The results showed a significant difference in mindfulness-acceptance and commitment intervention in the experimental group on pre- vs. post-test and pre-test vs. follow-up scores of research variables. Also, a comparison of groups using independent T-test analysis showed a significant effect of mindfulness-acceptance and commitment exercises on research variables in the experimental group in the post-test and follow-up stages.

Conclusion: Findings suggest that mindfulness, commitment, and acceptance exercises can be used as a new method to reduce rumination and increase cognitive flexibility and sports performance of elite beach soccer players.

背景/目的:很少有研究表明心理学新方法的有效性,包括正念接受承诺,尤其是在团队学科中。因此,本研究在两个月的随访中比较了精英沙滩足球运动员在沉思、认知灵活性和运动表现方面基于正念接受和承诺的方法。方法:研究设计包括随机对照试验(RCT)和随访。因此,34名沙滩足球超级联赛的球员根据正念接受和承诺被随机分为干预组和对照组。实验组的练习包括每周一次,持续7周和每天的家庭作业。参与者在干预前后和随访两个月时填写了反刍反应量表、认知灵活性量表和运动表现问卷。结果:采用多变量方差分析(MANOVA)和重复测量方差分析(ANOVA)来评估随时间的变化,并比较两组受试者的得分。结果显示,实验组在研究变量的测试前与测试后以及测试前与随访得分方面,正念接受和承诺干预存在显著差异。此外,使用独立T检验分析的组间比较显示,在测试后和随访阶段,正念接受和承诺练习对实验组的研究变量有显著影响。结论:研究结果表明,正念、承诺和接受练习可以作为一种新的方法来减少沉思,提高精英沙滩足球运动员的认知灵活性和运动成绩。
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引用次数: 2
Development and Validation of the Questionnaire for Adaptive Hyperactivity and Goal Achievement (AHGA). 适应性超活动和目标实现问卷的开发和验证(AHGA)。
Q2 Medicine Pub Date : 2023-05-12 eCollection Date: 2023-01-01 DOI: 10.2174/17450179-v19-e230419-2022-50
Goce Kalcev, Giulia Cossu, Antonio Preti, Maria Teresa Littera, Stèphanie Frau, Diego Primavera, Rosanna Zaccheddu, Veronica Matza, Marta Ermellino, Elisa Pintus, Mauro G Carta

Objective: This paper illustrates the preliminary psychometric properties of the Questionnaire for Adaptive Hyperactivity and Goal Achievement (AHGA), aimed at measuring adaptive characteristics of hyperactivity and goal pursuit in older adults.

Methods: The 12-item scale was administered to a sample of 120 subjects (older adults) between February 2022 and June 2022. The reliability of AHGA was measured using Cronbach's alpha, and factor structure was established using parallel analysis (PA) and principal component analysis (PCA). Convergent validity was tested against the Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN).

Results: All included subjects have an average age of 74.1±5.1 years. AHGA reliability was good (Cronbach's alpha: 0.713 [95%CI: 0.630 to 0.783]). Factor analysis suggested two main components: goal achievement and hyperactivity, which explained 41% of the variance in the data. The results support the convergent validity of the scale: AHGA measures adaptive characteristics of hyperactivity and goal pursuit, in contrast to BRIAN, which measures pathological characteristics.

Conclusion: The reported findings represent an innovative approach to hyperthymic features by embracing a broader spectrum concept that conceptualizes the potential transition between pathological and adaptive aspects as a continuum.

目的:本文阐述了适应性多动和目标实现问卷(AHGA)的初步心理测量特性,旨在测量老年人多动和目标追求的适应性特征。方法:在2022年2月至2022年6月期间,对120名受试者(老年人)进行12项量表。AHGA的可靠性使用Cronbachα进行测量,并使用平行分析(PA)和主成分分析(PCA)建立因子结构。结果:所有受试者的平均年龄为74.1±5.1岁。AHGA的可靠性良好(Cronbachα=0.713[95%CI:0.630至0.783])。因素分析表明有两个主要组成部分:目标实现和多动,这解释了数据中41%的差异。结果支持量表的收敛有效性:AHGA测量多动和目标追求的适应性特征,而BRIAN测量病理特征。结论:报告的发现代表了一种创新的方法来治疗高血压特征,它包含了一个更广泛的概念,将病理和适应性方面之间的潜在转变概念化为一个连续体。
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引用次数: 5
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Clinical Practice and Epidemiology in Mental Health
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