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Dexmedetomidine in the Treatment of Depression: An Up-to-date Narrative Review. 右美托咪定治疗抑郁症:最新叙事综述。
Q2 Medicine Pub Date : 2023-08-30 eCollection Date: 2023-01-01 DOI: 10.2174/17450179-v19-230823-2023-4
Tamadhir Al-Mahrouqi, Mohammed Al Alawi, Rafael C Freire
Depressive disorders (DD) are common, and their prevalence is expected to rise over the next decade. Depressive disorders are linked to significant morbidity and mortality. The clinical conundrum of depressive disorders lies in the heterogeneity of their phenomenology and etiology. Further, the currently available antidepressants have several limitations, including a delayed onset of action, limited efficacy, and an unfavorable side effect profile. In this review, Dexmedetomidine (DEX), a highly selective and potent α2-adrenergic receptor (α2-AR) agonist, is proposed as a potentially novel antidepressant with multiple mechanisms of action targeting various depression pathophysiological processes. These mechanisms include modulation of the noradrenergic system, regulation of neuroinflammation and oxidative stress, influence on the Brain-Derived Neurotrophic Factor (BDNF) levels, and modulation of neurotransmitter systems, such as glutamate. The review begins with an introduction before moving on to a discussion of DEX's pharmacological features. The pathophysiological and phenomenological targets of DD are also explored, along with the review of the existing preclinical and clinical evidence for DEX's putative anti-depressant effects. Finally, the review ends by presenting the pertinent conclusions and future directions.
抑郁症(DD)很常见,预计其患病率将在未来十年内上升。抑郁症与显著的发病率和死亡率有关。抑郁症的临床难题在于其现象学和病因的异质性。此外,目前可用的抗抑郁药有几个局限性,包括起效延迟、疗效有限和不良副作用。在这篇综述中,右美托咪定(DEX)是一种高选择性和强效的α2-肾上腺素能受体(α2-AR)激动剂,被认为是一种潜在的新型抗抑郁药,具有多种针对抑郁症病理生理过程的作用机制。这些机制包括去甲肾上腺素能系统的调节、神经炎症和氧化应激的调节、对脑源性神经营养因子(BDNF)水平的影响以及神经递质系统(如谷氨酸)的调节。这篇综述从引言开始,然后讨论DEX的药理学特征。还探讨了DD的病理生理学和现象学靶点,以及DEX假定的抗抑郁作用的现有临床前和临床证据的综述。最后,审查结束时提出了相关结论和未来方向。
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引用次数: 2
The Effectiveness of Telephone-based Psychological Services to COVID-19. 新冠肺炎电话心理服务的有效性。
Q2 Medicine Pub Date : 2023-08-30 eCollection Date: 2023-01-01 DOI: 10.2174/17450179-v19-230824-2023-11
Mojgan Khademi, Roya Vaziri-Harami, Amin Mahouram Mashadi, Pegah Seif, Abbas Babazadehdezfoly

Background: The COVID-19 pandemic has disrupted the delivery of mental health services, leading to the development of telepsychiatry.

Aim: The present study investigates the effectiveness of telephone-delivered treatment for psychological disorders of COVID-19 survivors in Tehran, the capital of Iran.

Methods: In this non-randomized controlled trial, 91 COVID-19 survivors, primarily residents were enrolled. Participants completed a baseline questionnaire and a psychological screening questionnaire. The intervention included the telephone-based psychological services provided by trained psychiatric residents. The Post-Traumatic Stress Disorder (PTSD) Checklist (PCL) was administered to assess the presence of PTSD symptoms. Symptoms of anxiety and depression were measured by the Patient Health Questionnaire.

Results: The General Health Questionnaire (GHQ) adjusted mean difference was significantly lower in the intervention group than in the control group. There was a significant negative correlation between the Spost-GHQ score and history of going to the clinic and history of psychiatric disorders, but no relationship with the history of hospitalization. All participants completed the satisfaction form, with almost half of them being "satisfied" or "very satisfied" with the telehealth calls.

Conclusion: Telephonic delivery of psychological services showed an effective way of providing evidence-based psychological support during the pandemic. This telehealth program can offer much-needed assistance to individuals with COVID-19 improving their psychological wellbeing.

背景:新冠肺炎大流行扰乱了心理健康服务的提供,导致远程精神病学的发展。目的:本研究调查了新冠肺炎幸存者在伊朗首都德黑兰接受电话治疗的有效性。方法:在这项非随机对照试验中,纳入了91名新冠肺炎幸存者,主要是居民。参与者完成了一份基线问卷和一份心理筛查问卷。干预措施包括由受过培训的精神病住院医师提供电话心理服务。创伤后应激障碍(PTSD)检查表(PCL)用于评估PTSD症状的存在。焦虑和抑郁症状通过患者健康问卷进行测量。结果:干预组的一般健康问卷(GHQ)调整平均差异显著低于对照组。Spost GHQ评分与就诊史和精神障碍史呈显著负相关,但与住院史无关。所有参与者都填写了满意度表,其中近一半的人对远程医疗电话感到“满意”或“非常满意”。结论:在疫情期间,电话提供心理服务是提供循证心理支持的有效途径。这项远程医疗计划可以为新冠肺炎患者提供急需的帮助,改善他们的心理健康。
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引用次数: 0
Why is it Important to Assess and Treat Alexithymia in the Cardiologic Field? An Overview of the Literature. 为什么在心脏病学领域评估和治疗述情障碍很重要?文学综述。
Q2 Medicine Pub Date : 2023-08-15 eCollection Date: 2023-01-01 DOI: 10.2174/17450179-v19-230810-2022-HT15-4764-1
Federica Sancassiani, Roberta Montisci, Luigi Meloni, Antonio Egidio Nardi, Mauro Giovanni Carta

Background: Alexithymia has been found to be associated with several somatic illnesses, such as cardiovascular, indicating that it might be a risk factor for early death in the long-term course of post-myocardial infarction. From the cardiology perspective, the aim was to collect current evidence about the relationship between alexithymia and somatic illness.

Methods: The literature was synthesized and summarized in a narrative format. The literature search was carried out in PubMed. Pertinent studies published in the last 50 years written in English were included and organized by three main topics ("The relation between alexithymia and somatic illness from the cardiology perspective"; "How do assess alexithymia?"; "Treating alexithymia") to be discussed.

Results: High alexithymia is a dimensional trait that affects around 10% of the general population and up to 55% of people with essential hypertension. Also, the link between alexithymia and cardiovascular activity has been pointed out. There are several validated tools to assess alexithymia, as well as treatment options.

Conclusion: Knowledge about the main features of alexithymia, as well as its assessment and treatment, can promote a multifactorial approach to the primary, secondary, and tertiary prevention of cardiac diseases.

背景:Alexithymia已被发现与几种躯体疾病有关,如心血管疾病,这表明它可能是心肌梗死后长期死亡的一个危险因素。从心脏病学的角度来看,目的是收集目前有关述情障碍与躯体疾病之间关系的证据。方法:以叙述的形式对文献进行综合总结。文献检索在PubMed进行。过去50年中发表的相关研究以英语撰写,分为三个主要主题(“从心脏病学的角度来看述情障碍与躯体疾病之间的关系”;“如何评估述情障碍?”;“治疗述情障碍”)进行讨论。结果:高度述情障碍是一种维度特征,影响约10%的普通人群和高达55%的原发性高血压患者。此外,还指出了述情障碍与心血管活动之间的联系。有几种经过验证的工具可以评估述情障碍,以及治疗方案。结论:了解述情障碍的主要特征及其评估和治疗,可以促进对心脏病的一级、二级和三级预防采取多因素方法。
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引用次数: 0
Burnout among Brazilian Dentists during the COVID-19 Pandemic: A Cross-sectional Study. 新冠肺炎大流行期间巴西牙医的精疲力竭:一项跨部门研究。
Q2 Medicine Pub Date : 2023-08-02 eCollection Date: 2023-01-01 DOI: 10.2174/17450179-v19-e230717-2023-1
Juliane Kely F Silva, Fernando M Carvalho, Carolina F Azevedo, Marcos Vinicius S Silva, Arthur Igor C Lima, Liliane Lins-Kusterer

Background: This article identifies the factors associated with burnout among dentists in the state of Bahia, Brazil, during the COVID-19 pandemic.

Methods: A cross-sectional study, conducted between November 2020 and February 2021, of 251 dentists, selected by snowball sampling. Sociodemographic, occupational, and epidemiological information was collected in an electronic form. Burnout was evaluated through the Maslach Burnout Inventory; anxiety through the Beck Anxiety Inventory; and quality of life through the WHOQol-BREF questionnaire. Multiple linear regression was used to identify factors associated with variations in levels of the three burnout dimensions.

Results: The mean levels of the burnout dimensions were: Emotional Exhaustion: 28.9 ± 8.9 (SD); Depersonalization = 8.2 ± 6.3; and Personal Accomplishment: 28.0 ± 6.2. The proportion of professionals with high Emotional Exhaustion (≥ 30 cut-off score), high Depersonalization (≥ 12 cut-off score), and low Personal Accomplishment (≤ 33 cut-off score) were 43.4%, 26.3% and 81.3%, respectively. Burnout components were associated with high anxiety; lower levels of the physical, psychological, social relations, and environmental dimensions of quality of life; less time working as a dentist; increased alcohol consumption during the pandemic, feeling safe when using personal protective equipment, and support from work fellows.

Conclusion: The dentists investigated showed moderate levels of Emotional Exhaustion and Depersonalization, and very low levels of Personal Accomplishment. The prevention and mitigation of burnout syndrome among dentists during a pandemic should consider several factors, such as quality of life, amount of time in the profession, use of personal protective equipment, support from fellow dentists, and alcohol consumption.

背景:本文确定了新冠肺炎大流行期间巴西巴伊亚州牙医职业倦怠的相关因素。方法:在2020年11月至2021年2月期间进行的一项横断面研究中,251名牙医通过滚雪球抽样进行了选择。社会形态、职业和流行病学信息以电子形式收集。通过Maslach倦怠量表评估倦怠;贝克焦虑量表焦虑;以及通过WHOQol BREF问卷调查的生活质量。多元线性回归用于确定与三个倦怠维度水平变化相关的因素。结果:职业倦怠维度的平均水平为:情绪耗竭:28.9±8.9(SD);人格解体=8.2±6.3;个人成就:28.0±6.2。高情绪耗竭(≥30分)、高人格解体(≥12分)和低个人成就感(≤33分)的专业人员比例分别为43.4%、26.3%和81.3%。倦怠成分与高度焦虑相关;生活质量的生理、心理、社会关系和环境层面较低;牙医工作时间减少;疫情期间饮酒量增加,使用个人防护设备时感到安全,并得到同事的支持。结论:被调查的牙医表现出中等程度的情绪耗竭和人格解体,而个人成就感水平很低。在大流行期间,预防和缓解牙医的倦怠综合征应考虑几个因素,如生活质量、职业时间、个人防护设备的使用、牙医同事的支持和饮酒。
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引用次数: 0
Delphi Survey of Items for the Test of Stuttering Screening in Children (TSSC). 儿童口吃筛查项目的德尔菲调查(TSSC)。
Q2 Medicine Pub Date : 2023-07-26 eCollection Date: 2023-01-01 DOI: 10.2174/17450179-v19-230615-2022-27
Aiswarya Liz Varghese, Radish Kumar Balasubramanium, Gagan Bajaj, Sudhin Karuppali, Unnikrishnan Bhaskaran

Purpose: Stuttering is a fluency disorder that mostly begins in childhood and affects many people in our societies. No standardized screening tools are available to check for stuttering in the Indian school-going population. Thus, the study aimed at developing a screening tool to identify children who stutter among the school-going population using a Delphi-based approach.

Methods: This study was carried out in four phases. During the first phase, five Speech Language Pathologists (SLPs) were asked about the need for screening and the nature & attributes of a stuttering screening test for school-going children. The second phase involved constructing appropriate stimuli for the screening tool based on expert opinion, relevant literature and students' academic textbooks. The third phase involved content validation of the speech elicitation stimuli by four teachers, five SLPs and an English Lecturer teaching in a university. The fourth phase encompassed the development of differential diagnosis criteria for stuttering identification in children using a rank analysis of the expert opinions.

Results: A stuttering screening stimuli comprising age, language and culture-specific reading, picture description and narration tasks for 1st to 10th-standard students was developed. The contents of the tool obtained satisfactory consensus of agreement among the panel of experts. Further, the tool outlined five critical diagnostic criteria which could differentially diagnose school-going children with stuttering from typically speaking counterparts using the developed material.

Conclusion: The developed screening tool could help practicing clinicians quickly identify stuttering in school-going populations. This would enable early identification and build up the statistical data to estimate the prevalence of stuttering among the school-going population. Further studies examining the psychometric properties of the developed test are in progress.

目的:口吃是一种流利性障碍,主要始于儿童时期,影响着我们社会中的许多人。目前还没有标准化的筛查工具来检查印度在校人群的口吃情况。因此,该研究旨在开发一种筛查工具,使用基于德尔菲的方法在在校人群中识别口吃儿童。方法:本研究分四个阶段进行。在第一阶段,五名言语语言病理学家(SLP)被问及筛查的必要性以及针对在校儿童的口吃筛查测试的性质和特点。第二阶段涉及根据专家意见、相关文献和学生的学术教科书为筛选工具构建适当的刺激因素。第三阶段涉及四名教师、五名SLP和一名大学英语讲师对言语启发刺激的内容验证。第四阶段包括使用专家意见的等级分析来制定儿童口吃识别的鉴别诊断标准。结果:为1至10年级标准学生开发了包括年龄、语言和文化特定阅读、图片描述和叙述任务的口吃筛查刺激。该工具的内容在专家小组中获得了令人满意的一致意见。此外,该工具概述了五个关键的诊断标准,这些标准可以使用开发的材料对上学的口吃儿童与说话正常的儿童进行区别诊断。结论:开发的筛查工具可以帮助临床医生快速识别在校人群中的口吃。这将有助于早期识别并建立统计数据,以估计在校人群中口吃的患病率。对所开发测试的心理测量特性的进一步研究正在进行中。
{"title":"Delphi Survey of Items for the Test of Stuttering Screening in Children (TSSC).","authors":"Aiswarya Liz Varghese,&nbsp;Radish Kumar Balasubramanium,&nbsp;Gagan Bajaj,&nbsp;Sudhin Karuppali,&nbsp;Unnikrishnan Bhaskaran","doi":"10.2174/17450179-v19-230615-2022-27","DOIUrl":"https://doi.org/10.2174/17450179-v19-230615-2022-27","url":null,"abstract":"<p><strong>Purpose: </strong>Stuttering is a fluency disorder that mostly begins in childhood and affects many people in our societies. No standardized screening tools are available to check for stuttering in the Indian school-going population. Thus, the study aimed at developing a screening tool to identify children who stutter among the school-going population using a Delphi-based approach.</p><p><strong>Methods: </strong>This study was carried out in four phases. During the first phase, five Speech Language Pathologists (SLPs) were asked about the need for screening and the nature & attributes of a stuttering screening test for school-going children. The second phase involved constructing appropriate stimuli for the screening tool based on expert opinion, relevant literature and students' academic textbooks. The third phase involved content validation of the speech elicitation stimuli by four teachers, five SLPs and an English Lecturer teaching in a university. The fourth phase encompassed the development of differential diagnosis criteria for stuttering identification in children using a rank analysis of the expert opinions.</p><p><strong>Results: </strong>A stuttering screening stimuli comprising age, language and culture-specific reading, picture description and narration tasks for 1<sup>st</sup> to 10<sup>th</sup>-standard students was developed. The contents of the tool obtained satisfactory consensus of agreement among the panel of experts. Further, the tool outlined five critical diagnostic criteria which could differentially diagnose school-going children with stuttering from typically speaking counterparts using the developed material.</p><p><strong>Conclusion: </strong>The developed screening tool could help practicing clinicians quickly identify stuttering in school-going populations. This would enable early identification and build up the statistical data to estimate the prevalence of stuttering among the school-going population. Further studies examining the psychometric properties of the developed test are in progress.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71427510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physical Activity Reduces Depression among Healthcare Workers during the COVID-19 Pandemic in Jordan. 在约旦新冠肺炎大流行期间,体育活动减少了医护人员的抑郁症。
Q2 Medicine Pub Date : 2023-07-25 eCollection Date: 2023-01-01 DOI: 10.2174/17450179-v19-230720-2023-8
Abdulhakeem Okour, Basil Amarneh

Aims: This study aimed to assess mental health status by measuring depression and investigating the effect of physical activity in lessening the mental health burden among HCWs during the COVID-19 pandemic in Jordan.

Background: The COVID-19 pandemic has caused distress and depression among healthcare workers and drastic disruptions in social, economic, and health systems worldwide.

Methods: A cross-sectional online study through google forms involved HCWs across Jordan for two months. The 10-item short form of the Center for Epidemiological Studies Depression Scale Revised (CESD-R10) was used to assess depressive symptoms.

Results: The total sample was 295, females were 50.5% with mean age of 33.1 (>80% less than 40 years old), married 51.9%, 63% were physicians, 88.1% had contact with patients, and 64.7% were smokers. Depression symptoms were perceived by 59.3% of the total samples (53.1).

Conclusion: During the COVID-19-induced nationwide lockdown in Jordan, HCWs who engaged in enough physical exercise reported fewer depressive symptoms. Promoting physical exercise among HCWs may lead to better results for their mental health. Various clinical implications support promoting designated time and space for physical activity at work.

目的:本研究旨在通过测量抑郁情绪来评估心理健康状况,并调查在约旦新冠肺炎大流行期间,体育活动在减轻HCW心理健康负担方面的作用。背景:新冠肺炎大流行已在全世界医护人员中造成痛苦和抑郁,并严重破坏了社会、经济和卫生系统。方法:一项通过谷歌表格进行的横断面在线研究涉及约旦各地的HCW,为期两个月。流行病学研究中心抑郁量表修订版(CESD-R10)的10项简表用于评估抑郁症状。结果:总样本为295人,女性占50.5%,平均年龄33.1岁(>80%小于40岁),已婚51.9%,63%为医生,88.1%与患者有过接触,64.7%为吸烟者。59.3%的样本(53.1)感知到抑郁症状。结论:在新冠肺炎引发的约旦全国封锁期间,参加足够体育锻炼的医务人员报告的抑郁症状较少。在HCW中促进体育锻炼可以为他们的心理健康带来更好的结果。各种临床意义支持促进指定的时间和空间在工作中进行体育活动。
{"title":"Physical Activity Reduces Depression among Healthcare Workers during the COVID-19 Pandemic in Jordan.","authors":"Abdulhakeem Okour,&nbsp;Basil Amarneh","doi":"10.2174/17450179-v19-230720-2023-8","DOIUrl":"https://doi.org/10.2174/17450179-v19-230720-2023-8","url":null,"abstract":"<p><strong>Aims: </strong>This study aimed to assess mental health status by measuring depression and investigating the effect of physical activity in lessening the mental health burden among HCWs during the COVID-19 pandemic in Jordan.</p><p><strong>Background: </strong>The COVID-19 pandemic has caused distress and depression among healthcare workers and drastic disruptions in social, economic, and health systems worldwide.</p><p><strong>Methods: </strong>A cross-sectional online study through google forms involved HCWs across Jordan for two months. The 10-item short form of the Center for Epidemiological Studies Depression Scale Revised (CESD-R10) was used to assess depressive symptoms.</p><p><strong>Results: </strong>The total sample was 295, females were 50.5% with mean age of 33.1 (>80% less than 40 years old), married 51.9%, 63% were physicians, 88.1% had contact with patients, and 64.7% were smokers. Depression symptoms were perceived by 59.3% of the total samples (53.1).</p><p><strong>Conclusion: </strong>During the COVID-19-induced nationwide lockdown in Jordan, HCWs who engaged in enough physical exercise reported fewer depressive symptoms. Promoting physical exercise among HCWs may lead to better results for their mental health. Various clinical implications support promoting designated time and space for physical activity at work.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71427517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vaccination as a Significant Factor Influencing the Psychoemotional State of Medical Students During the Sars-Cov-2 Pandemic: An International Aspect. 在新冠肺炎疫情期间,疫苗接种是影响医学生心理情绪状态的重要因素:一个国际方面。
Q2 Medicine Pub Date : 2023-07-11 eCollection Date: 2023-01-01 DOI: 10.2174/1745-0179-v19-e230420-2022-49
Maria V Sankova, Vladimir N Nikolenko, Tatiana M Litvinova, Beatrice A Volel, Marina V Oganesyan, Andjela D Vovkogon, Negoria A Rizaeva, Sergey V Sankov, Mikhail Y Sinelnikov

Background: The rapid spread of SARS-COV-2, characterized by its severe course in the absence of effective specific treatment for this infection, may become a significant risk factor for psycho-emotional disorders' emergence during this pandemic. One of the vulnerable groups in the current situation are first-year medical students, whose problems associated with an unfavorable sanitary-epidemiological situation and an increased infection risk are compounded by the difficulties of adapting to specific professional environments. In this situation, along with strict adherence to nonspecific prevention methods, the mass student SARS-COV-2 vaccination acquires particular importance.

Objective: To compare the attitudes of first-year medical students in Russia and Azerbaijan toward SARS-COV-2 immunization and to assess the vaccination impact on the student's psycho-emotional state during the SARS-COV-2 pandemic.

Materials and methods: The study involved 594 first-year students at the Moscow and Baku branches of Sechenov University. The Google Forms platform was used to conduct an anonymous sociological survey. To compare the psychoemotional state of vaccinated freshmen and non-vaccinated students, we used the State-Trait Anxiety Inventory, STAI, to assess reactive anxiety and the Beck Depression Inventory test - to diagnose depressive symptoms. The online survey was conducted during the fourth wave of coronavirus infection. WHO official sources were used to analyze the current epidemiological SARS-COV-2 situation during the study data provided by the Russian Federal Service on Customers' Rights Protection and Human Well-Being Surveillance and JHU CSSE. Statistical analysis was carried out using RStudio.

Results: The study results showed that vaccination coverage of first-year students at the Moscow branch of Sechenov University during the fourth wave of the SARS-COV-2 pandemic was 42,9±5,13%, at the Baku branch - 69,6±5,86%. The lack of reliable information about anticovid vaccines, indicated by a third of all respondents, may largely determine the motivated participation in the vaccination SARS-COV-2 campaign. The role of medical school in imparting knowledge about active SARS-COV-2 immunization to medical students was found to be insignificant. It was shown that the percentage of students willing to recommend SARS-COV-2 vaccination to the people around them and thereby contribute to increasing collective immunity level significantly depends on the percentage of students vaccinated. It was proved that vaccinated students were characterized by significantly greater psychological stability regardless of their study place.

Conclusion: Vaccination is not only a good preventive measure against the infection spread but also a significant factor in stabilizing the psycho-emotional state of first-year students, which significantly affects the quality

背景:严重急性呼吸系统综合征冠状病毒2型的快速传播,其特点是在缺乏有效的特异性治疗的情况下,其病程严重,可能成为此次疫情期间出现心理情绪障碍的一个重要风险因素。目前情况下的弱势群体之一是一年级的医学生,他们的问题与不利的卫生流行病学状况和感染风险增加有关,再加上难以适应特定的专业环境。在这种情况下,随着严格遵守非特异性预防方法,大规模学生接种严重急性呼吸系统综合征冠状病毒2型疫苗变得尤为重要。目的:比较俄罗斯和阿塞拜疆医学院一年级学生对严重急性呼吸系统综合征冠状病毒2型疫苗接种的态度,并评估疫苗接种对严重急性呼吸道综合征病毒2型疫情期间学生心理情绪状态的影响。材料和方法:这项研究涉及谢切诺夫大学莫斯科和巴库分校的594名一年级学生。谷歌表单平台被用来进行一项匿名的社会学调查。为了比较接种疫苗的新生和未接种疫苗的学生的心理情绪状态,我们使用状态-特质焦虑量表(STAI)来评估反应性焦虑,并使用贝克抑郁量表测试来诊断抑郁症状。这项在线调查是在第四波冠状病毒感染期间进行的。在俄罗斯联邦客户权利保护和人类健康监测服务局和JHU CSSE提供的研究数据中,使用世界卫生组织官方来源分析了目前SARS-COV-2的流行病学状况。使用RStudio进行统计分析。结果:研究结果显示,在第四波严重急性呼吸系统综合征冠状病毒2型疫情期间,谢切诺夫大学莫斯科分校一年级学生的疫苗接种覆盖率为42,9±5,13%,巴库分校为69,6±5,86%。三分之一的受访者表示,缺乏有关抗冠状病毒疫苗的可靠信息,这可能在很大程度上决定了是否有动机参与接种严重急性呼吸系统综合征冠状病毒2型疫苗。医学院在向医学生传授积极的严重急性呼吸系统综合征冠状病毒2型免疫知识方面的作用被发现是微不足道的。研究表明,愿意向周围人推荐接种严重急性呼吸系统综合征冠状病毒2型疫苗从而有助于提高集体免疫水平的学生比例在很大程度上取决于接种疫苗的学生比例。事实证明,接种疫苗的学生无论在哪里学习,都具有显著更大的心理稳定性。结论:接种疫苗不仅是预防感染传播的良好措施,也是稳定一年级学生心理情绪状态的重要因素,对其教育过程的质量和有效性有重要影响。
{"title":"Vaccination as a Significant Factor Influencing the Psychoemotional State of Medical Students During the Sars-Cov-2 Pandemic: An International Aspect.","authors":"Maria V Sankova,&nbsp;Vladimir N Nikolenko,&nbsp;Tatiana M Litvinova,&nbsp;Beatrice A Volel,&nbsp;Marina V Oganesyan,&nbsp;Andjela D Vovkogon,&nbsp;Negoria A Rizaeva,&nbsp;Sergey V Sankov,&nbsp;Mikhail Y Sinelnikov","doi":"10.2174/1745-0179-v19-e230420-2022-49","DOIUrl":"https://doi.org/10.2174/1745-0179-v19-e230420-2022-49","url":null,"abstract":"<p><strong>Background: </strong>The rapid spread of SARS-COV-2, characterized by its severe course in the absence of effective specific treatment for this infection, may become a significant risk factor for psycho-emotional disorders' emergence during this pandemic. One of the vulnerable groups in the current situation are first-year medical students, whose problems associated with an unfavorable sanitary-epidemiological situation and an increased infection risk are compounded by the difficulties of adapting to specific professional environments. In this situation, along with strict adherence to nonspecific prevention methods, the mass student SARS-COV-2 vaccination acquires particular importance.</p><p><strong>Objective: </strong>To compare the attitudes of first-year medical students in Russia and Azerbaijan toward SARS-COV-2 immunization and to assess the vaccination impact on the student's psycho-emotional state during the SARS-COV-2 pandemic.</p><p><strong>Materials and methods: </strong>The study involved 594 first-year students at the Moscow and Baku branches of Sechenov University. The Google Forms platform was used to conduct an anonymous sociological survey. To compare the psychoemotional state of vaccinated freshmen and non-vaccinated students, we used the State-Trait Anxiety Inventory, STAI, to assess reactive anxiety and the Beck Depression Inventory test - to diagnose depressive symptoms. The online survey was conducted during the fourth wave of coronavirus infection. WHO official sources were used to analyze the current epidemiological SARS-COV-2 situation during the study data provided by the Russian Federal Service on Customers' Rights Protection and Human Well-Being Surveillance and JHU CSSE. Statistical analysis was carried out using RStudio.</p><p><strong>Results: </strong>The study results showed that vaccination coverage of first-year students at the Moscow branch of Sechenov University during the fourth wave of the SARS-COV-2 pandemic was 42,9±5,13%, at the Baku branch - 69,6±5,86%. The lack of reliable information about anticovid vaccines, indicated by a third of all respondents, may largely determine the motivated participation in the vaccination SARS-COV-2 campaign. The role of medical school in imparting knowledge about active SARS-COV-2 immunization to medical students was found to be insignificant. It was shown that the percentage of students willing to recommend SARS-COV-2 vaccination to the people around them and thereby contribute to increasing collective immunity level significantly depends on the percentage of students vaccinated. It was proved that vaccinated students were characterized by significantly greater psychological stability regardless of their study place.</p><p><strong>Conclusion: </strong>Vaccination is not only a good preventive measure against the infection spread but also a significant factor in stabilizing the psycho-emotional state of first-year students, which significantly affects the quality","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10487339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71427522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between Proinflammatory Cytokines and Anxiety and Depression Symptoms in Rheumatoid Arthritis Patients: A Cross-sectional Study. 类风湿性关节炎患者的促炎细胞因子与焦虑和抑郁症状之间的关系:一项横断面研究。
Q2 Medicine Pub Date : 2023-06-22 eCollection Date: 2023-01-01 DOI: 10.2174/17450179-v19-e230510-2022-34
Faisal Parlindungan, Rudy Hidayat, Anna Ariane, Hamzah Shatri

Background: Rheumatoid arthritis (RA) patients have a greater prevalence of anxiety and depression. Proinflammatory cytokines are elevated in RA. We aim to evaluate the association between systemic inflammation in RA and anxiety and depression.

Methods: There were 31 RA patients, 16 with active disease activity and 15 in remission state; they were assessed using the Hospital Anxiety and Depression Scale and for RA disease activity using Disease Activity Score of 28 joints (DAS28) - CRP (C-reactive protein). Serum proinflammatory cytokines were measured, including interleukin (IL)-6, IL-17, and Tumour Necrosis Factor-alpha (TNF-α).

Results: Among 31 patients, ten patients showed anxiety symptoms, 19 patients showed depression symptoms, and two displayed mixed symptoms. Serum TNF-α levels were significantly higher in active disease than in the remission group (p-value 0.006). There was no association or correlation between proinflammatory cytokines to anxiety and depression symptoms in the active disease and remission groups.

Conclusion: This suggests that other factors besides disease activity and state of systemic inflammation may cause anxiety and depression in RA patients.

背景:类风湿性关节炎(RA)患者焦虑和抑郁的患病率较高。RA患者的炎性细胞因子升高。我们的目的是评估RA的全身炎症与焦虑和抑郁之间的关系。方法:RA患者31例,活动期16例,缓解期15例;他们使用医院焦虑和抑郁量表进行评估,并使用28关节疾病活动评分(DAS28)-CRP(C反应蛋白)进行RA疾病活动评估。结果:31例患者中,10例出现焦虑症状,19例出现抑郁症状,2例出现混合症状。活动性疾病患者血清TNF-α水平显著高于缓解组(p值0.006)。活动性疾病组和缓解组的促炎细胞因子与焦虑和抑郁症状之间没有关联或相关性。结论:RA患者除疾病活动和全身炎症状态外,还可能存在其他因素引起焦虑和抑郁。
{"title":"Association between Proinflammatory Cytokines and Anxiety and Depression Symptoms in Rheumatoid Arthritis Patients: A Cross-sectional Study.","authors":"Faisal Parlindungan,&nbsp;Rudy Hidayat,&nbsp;Anna Ariane,&nbsp;Hamzah Shatri","doi":"10.2174/17450179-v19-e230510-2022-34","DOIUrl":"https://doi.org/10.2174/17450179-v19-e230510-2022-34","url":null,"abstract":"<p><strong>Background: </strong>Rheumatoid arthritis (RA) patients have a greater prevalence of anxiety and depression. Proinflammatory cytokines are elevated in RA. We aim to evaluate the association between systemic inflammation in RA and anxiety and depression.</p><p><strong>Methods: </strong>There were 31 RA patients, 16 with active disease activity and 15 in remission state; they were assessed using the Hospital Anxiety and Depression Scale and for RA disease activity using Disease Activity Score of 28 joints (DAS28) - CRP (C-reactive protein). Serum proinflammatory cytokines were measured, including interleukin (IL)-6, IL-17, and Tumour Necrosis Factor-alpha (TNF-α).</p><p><strong>Results: </strong>Among 31 patients, ten patients showed anxiety symptoms, 19 patients showed depression symptoms, and two displayed mixed symptoms. Serum TNF-α levels were significantly higher in active disease than in the remission group (p-value 0.006). There was no association or correlation between proinflammatory cytokines to anxiety and depression symptoms in the active disease and remission groups.</p><p><strong>Conclusion: </strong>This suggests that other factors besides disease activity and state of systemic inflammation may cause anxiety and depression in RA patients.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71427508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mental Health: Pandemics, Epidemics and Tau Protein. 心理健康:流行病、流行病和Tau蛋白。
Q2 Medicine Pub Date : 2023-06-21 eCollection Date: 2023-01-01 DOI: 10.2174/17450179-v19-e230510-2022-51
Ghinwa M Barakat, Ghaith Assi, Noura B El Khoury

Background: It is well established that a wide range of psychological disorders are influenced by the way people live, with lifestyle-related factors playing a substantial role. During the past decade, the effects of major disasters on mental health have drawn a lot of attention.

Aim: In this review, we compare clinical studies reporting a link between COVID-19 and other pandemics and mental health. Importantly, we also shed light on Tau protein and neurotransmitters as neurobiological factors that might explain this link.

Methods: A thorough PubMed search was done to gather and summarize published data on the COVID-19 pandemic's effect on mental health. Additionally, these studies were compared to previous research published on PubMed, triggering other pandemic and epidemic impacts on mental health.

Results: The COVID-19 epidemic has had the biggest impact on raising awareness about mental health. Moreover, the past century has seen an increase in the frequency of disease outbreaks like MERS-CoV, Ebola, and Influenza, which all had an impact on mental health. However, the exact role of these epidemics on mental health and brain functions is poorly understood.

Conclusion: Future research on the underlying pathways may yield essential information for the treatment and prevention of prospective mental diseases in light of the ongoing decline in mental health during the past 10 years.

背景:众所周知,人们的生活方式会影响各种各样的心理障碍,与生活方式相关的因素在其中发挥着重要作用。在过去的十年里,重大灾难对心理健康的影响引起了人们的广泛关注。目的:在这篇综述中,我们比较了报告新冠肺炎与其他流行病和心理健康之间联系的临床研究。重要的是,我们还阐明了Tau蛋白和神经递质作为可能解释这种联系的神经生物学因素。方法:通过PubMed全面检索,收集和总结已发表的关于新冠肺炎大流行对心理健康影响的数据。此外,这些研究与之前发表在PubMed上的研究进行了比较,引发了其他大流行和流行病对心理健康的影响。结果:新冠肺炎疫情对提高心理健康意识的影响最大。此外,在过去的一个世纪里,MERS-CoV、埃博拉和流感等疾病爆发的频率有所增加,这些都对心理健康产生了影响。然而,人们对这些流行病对心理健康和大脑功能的确切作用知之甚少。结论:鉴于过去10年来心理健康的持续下降,未来对潜在途径的研究可能会为治疗和预防前瞻性心理疾病提供重要信息。
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引用次数: 0
The Impact of COVID-19 Confinement on Reading Behavior. 新冠肺炎隔离对阅读行为的影响。
Q2 Medicine Pub Date : 2023-06-05 eCollection Date: 2023-01-01 DOI: 10.2174/17450179-v19-e230505-2022-42
Mahmoud A Alomari, Omar F Khabour, Karem H Alzoubi, Aseel Aburub

Background: The COVID-19 pandemic was detrimental to lifestyle and behavior. In this investigation, changes in reading habits during the pandemic were examined.

Methods: The study is cross-sectional and survey-based. 1844 individuals completed an online survey about sociodemographic and reading habits during COVID-19. Multinomial logistic regression was used to examine the relationship between the study variables.

Results: Most of the participants were active readers (71.5%-83.2%). Fewer (13.8-18.0%) reported a decrease in reading, while about half reported a no change, and 1/3rd reported an increase. Changes in reading habits were related to age, education, job type, and income.

Conclusion: About half of the participants during the pandemic reported a change in reading habits. Interventions to further enhance reading among people during the pandemic might help ameliorate the negative impacts of the pandemic.

背景:新冠肺炎大流行对生活方式和行为有害。在这项调查中,研究了疫情期间阅读习惯的变化。方法:本研究采用横断面调查法。1844人完成了一项关于新冠肺炎期间社会人口统计和阅读习惯的在线调查。多元逻辑回归用于检验研究变量之间的关系。结果:大多数参与者都是活跃的读者(71.5%-83.2%)。很少有人(13.8-18.0%)报告阅读量下降,而大约一半的人报告没有变化,三分之一的人报告阅读量增加。阅读习惯的变化与年龄、教育程度、工作类型和收入有关。结论:在疫情期间,大约一半的参与者报告说阅读习惯发生了变化。在疫情期间进一步提高人们阅读能力的干预措施可能有助于减轻疫情的负面影响。
{"title":"The Impact of COVID-19 Confinement on Reading Behavior.","authors":"Mahmoud A Alomari,&nbsp;Omar F Khabour,&nbsp;Karem H Alzoubi,&nbsp;Aseel Aburub","doi":"10.2174/17450179-v19-e230505-2022-42","DOIUrl":"https://doi.org/10.2174/17450179-v19-e230505-2022-42","url":null,"abstract":"<p><strong>Background: </strong>The COVID-19 pandemic was detrimental to lifestyle and behavior. In this investigation, changes in reading habits during the pandemic were examined.</p><p><strong>Methods: </strong>The study is cross-sectional and survey-based. 1844 individuals completed an online survey about sociodemographic and reading habits during COVID-19. Multinomial logistic regression was used to examine the relationship between the study variables.</p><p><strong>Results: </strong>Most of the participants were active readers (71.5%-83.2%). Fewer (13.8-18.0%) reported a decrease in reading, while about half reported a no change, and 1/3<sup>rd</sup> reported an increase. Changes in reading habits were related to age, education, job type, and income.</p><p><strong>Conclusion: </strong>About half of the participants during the pandemic reported a change in reading habits. Interventions to further enhance reading among people during the pandemic might help ameliorate the negative impacts of the pandemic.</p>","PeriodicalId":35447,"journal":{"name":"Clinical Practice and Epidemiology in Mental Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71427520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
期刊
Clinical Practice and Epidemiology in Mental Health
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