{"title":"[JAPANESE PEDIATRIC GUIDELINES FOR THE TREATMENT AND MANAGEMENT OF ASTHMA (2023), \"MANAGEMENT OF ASTHMA: VARIOUS ASPECTS\"].","authors":"Tatsuki Fukuie, Satoshi Horino, Osamu Natsume, Katsushi Miura","doi":"10.15036/arerugi.74.324","DOIUrl":"https://doi.org/10.15036/arerugi.74.324","url":null,"abstract":"","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"74 6","pages":"324-329"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145726456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[RESPONSE AND PREPAREDNESS FOR ALLERGIC DISEASES DURING DISASTERS].","authors":"Shigetoshi Kobayashi","doi":"10.15036/arerugi.74.20","DOIUrl":"https://doi.org/10.15036/arerugi.74.20","url":null,"abstract":"","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"74 1","pages":"20-23"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sublingual immunotherapy (SLIT) with Japanese cedar induces changes in specific IgE antibodies titer (sIgE) over time. We investigated whether other antigens could synchronize with the changes in Japanese cedar by cedar SLIT.
Methods: The study included 429 cases of cedar SLIT (started between 2017 and 2022, 5-66 years old, 208 men, 49 Cedatren® and 380 Cedacure®, 254 only cedar SLIT and 175 combined mites SLIT). For three years, sIgE in cedar [n=429], cypress [412], orchard grass [152], ragweed [127], birch [106], alnus japonica [110], mite (Der f 1) [classified as 144 dual SLIT and 96 only cedar SLIT], cats [101] and dogs [84], and total IgE [417] were followed. Antigens except cedar were followed in cases class 1 (≥0.7UA/mL) before SLIT. The change (log difference) for each antigen compared to before SLIT was calculated each year, and the correlation with cedar was analyzed.
Results: By cedar SLIT, other pollen sIgE and total IgE fluctuated over time in sync with cedar, and log difference was significantly correlated with cedar, but perennial antigens in mites, cats, or dogs did not related with cedar.
Conclusion: Cedar SLIT may induce non-specific IgE production, and influence sIgE production on other pollens in a synchronous manner. Cedar SLIT is expected to have beneficial effects on seasonal allergic rhinitis by other pollen antigens.
杉木舌下免疫治疗（SLIT）可诱导特异性IgE抗体滴度（sIgE）随时间的变化。我们通过杉木的SLIT研究了其他抗原是否能与杉木的变化同步。方法：纳入429例杉木SLIT病例（开始于2017 - 2022年，5-66岁，男性208例，雪松®49例和雪松®380例，仅雪松SLIT 254例和联合SLIT 175例）。3年间，对雪松[n=429]、柏树[412]、果园草[152]、豚草[127]、桦树[106]、桤木[110]、螨（Der f 1）[双SLIT分类为144，单SLIT分类为96]、猫[101]、狗[84]、总IgE[417]进行sIgE追踪。1级患者（≥0.7UA/mL）在SLIT前检测除雪松外的抗原。每年计算各抗原与SLIT前的变化（对数差），并分析其与雪松的相关性。结果：通过雪松的SLIT，其他花粉sIgE和总IgE随时间的波动与雪松同步，原木差异与雪松显著相关，但螨虫、猫或狗的多年生抗原与雪松无关。结论：杉木SLIT可能诱导非特异性IgE的产生，并同步影响其他花粉sIgE的产生。其他花粉抗原对季节性变应性鼻炎的治疗也有一定的作用。
{"title":"[CHANGES IN CEDAR POLLEN SPECIFIC IGE ANTIBODIES TITER BY CEDAR SUBLINGUAL IMMUNOTHERAPY ARE SYNCHRONIZED WITH OTHER POLLEN ANTIGENS, BUT NOT WITH PERENNIAL ANTIGENS].","authors":"Atsushi Yuta, Yukiko Ogawa, Keigo Nakamura, Hideaki Kozaki, Takeshi Shimizu","doi":"10.15036/arerugi.74.139","DOIUrl":"https://doi.org/10.15036/arerugi.74.139","url":null,"abstract":"<p><p>Sublingual immunotherapy (SLIT) with Japanese cedar induces changes in specific IgE antibodies titer (sIgE) over time. We investigated whether other antigens could synchronize with the changes in Japanese cedar by cedar SLIT.</p><p><strong>Methods: </strong>The study included 429 cases of cedar SLIT (started between 2017 and 2022, 5-66 years old, 208 men, 49 Cedatren<sup>®</sup> and 380 Cedacure<sup>®</sup>, 254 only cedar SLIT and 175 combined mites SLIT). For three years, sIgE in cedar [n=429], cypress [412], orchard grass [152], ragweed [127], birch [106], alnus japonica [110], mite (Der f 1) [classified as 144 dual SLIT and 96 only cedar SLIT], cats [101] and dogs [84], and total IgE [417] were followed. Antigens except cedar were followed in cases class 1 (≥0.7UA/mL) before SLIT. The change (log difference) for each antigen compared to before SLIT was calculated each year, and the correlation with cedar was analyzed.</p><p><strong>Results: </strong>By cedar SLIT, other pollen sIgE and total IgE fluctuated over time in sync with cedar, and log difference was significantly correlated with cedar, but perennial antigens in mites, cats, or dogs did not related with cedar.</p><p><strong>Conclusion: </strong>Cedar SLIT may induce non-specific IgE production, and influence sIgE production on other pollens in a synchronous manner. Cedar SLIT is expected to have beneficial effects on seasonal allergic rhinitis by other pollen antigens.</p>","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"74 3","pages":"139-148"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[THE PAST, THE PRESENT, AND THE FUTURE OF PERIOSTIN].","authors":"Kenji Izuhara, Satoshi Nunomura, Yasuhiro Nanri, Yuko Honda","doi":"10.15036/arerugi.74.201","DOIUrl":"10.15036/arerugi.74.201","url":null,"abstract":"","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"74 4","pages":"201-205"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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