{"title":"[NATIONAL SURVEY OF IMMEDIATE TYPE FOOD ALLERGIES IN JAPAN IN 2023: A REPORT SUPPORTED BY A GRANT FROM THE CONSUMER AFFAIRS AGENCY, GOVERNMENT OF JAPAN].","authors":"Chizuko Sugizaki, Kyohei Takahashi, Sakura Sato, Noriyuki Yanagida, Motohiro Ebisawa","doi":"10.15036/arerugi.74.167","DOIUrl":"https://doi.org/10.15036/arerugi.74.167","url":null,"abstract":"","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"74 3","pages":"167-172"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Human β-defensin (hBD)-3 is an antimicrobial peptide that exhibits both antimicrobial and immunomodulatory activities, but its role in autophagy regulation remains unclear. Additionally, the role of autophagy in skin barrier regulation in atopic dermatitis (AD) is not well understood. This study aimed to investigate the role of autophagy in the skin lesions of AD patients and mouse models, as well as the effects of hBD-3 on autophagy and skin barrier function.
Methods: We assessed autophagy in epidermal keratinocytes from skin lesions of AD patients and an AD mouse model. We also examined the effects of hBD-3 on autophagy activation in epidermal keratinocytes and its ability to mitigate IL-4 and IL-13-induced tight junction (TJ) barrier disruption.
Results: Autophagy was suppressed in epidermal keratinocytes from both AD patients and the AD mouse model (in vivo). Interestingly, hBD-3 activated autophagy in these keratinocytes in vitro and alleviated IL-4 and IL-13-mediated TJ barrier disruption. Autophagy deficiency led to impaired skin barrier function and exacerbated inflammation in vivo. However, hBD-3 ameliorated skin inflammation and strengthened the TJ barrier in AD. Notably, hBD-3-mediated TJ barrier improvement was absent in autophagy-deficient AD mice (in vivo), highlighting the essential role of autophagy in the regulation of skin barrier function and inflammation by hBD-3 in AD.
Conclusion: This study suggests that hBD-3 plays a critical role in regulating the skin barrier and inflammation in AD through autophagy. hBD-3 holds potential as a therapeutic agent for skin diseases associated with autophagy dysfunction and skin barrier impairment, including AD.
{"title":"[ROLE OF ANTIMICROBIAL/HOST DEFENSE PEPTIDES ON SKIN BARRIER FUNCTION AND ACTIVATION OF AUTOPHAGY IN ATOPIC DERMATITIS].","authors":"Ge Peng, François Niyonsaba","doi":"10.15036/arerugi.74.149","DOIUrl":"10.15036/arerugi.74.149","url":null,"abstract":"<p><strong>Background: </strong>Human β-defensin (hBD)-3 is an antimicrobial peptide that exhibits both antimicrobial and immunomodulatory activities, but its role in autophagy regulation remains unclear. Additionally, the role of autophagy in skin barrier regulation in atopic dermatitis (AD) is not well understood. This study aimed to investigate the role of autophagy in the skin lesions of AD patients and mouse models, as well as the effects of hBD-3 on autophagy and skin barrier function.</p><p><strong>Methods: </strong>We assessed autophagy in epidermal keratinocytes from skin lesions of AD patients and an AD mouse model. We also examined the effects of hBD-3 on autophagy activation in epidermal keratinocytes and its ability to mitigate IL-4 and IL-13-induced tight junction (TJ) barrier disruption.</p><p><strong>Results: </strong>Autophagy was suppressed in epidermal keratinocytes from both AD patients and the AD mouse model (in vivo). Interestingly, hBD-3 activated autophagy in these keratinocytes in vitro and alleviated IL-4 and IL-13-mediated TJ barrier disruption. Autophagy deficiency led to impaired skin barrier function and exacerbated inflammation in vivo. However, hBD-3 ameliorated skin inflammation and strengthened the TJ barrier in AD. Notably, hBD-3-mediated TJ barrier improvement was absent in autophagy-deficient AD mice (in vivo), highlighting the essential role of autophagy in the regulation of skin barrier function and inflammation by hBD-3 in AD.</p><p><strong>Conclusion: </strong>This study suggests that hBD-3 plays a critical role in regulating the skin barrier and inflammation in AD through autophagy. hBD-3 holds potential as a therapeutic agent for skin diseases associated with autophagy dysfunction and skin barrier impairment, including AD.</p>","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"74 3","pages":"149-158"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[IDENTIFICATION AND CHARACTERIZATION OF NOVEL FOOD ALLERGY ALLERGENS AND THEIR ANALYTICAL METHODS].","authors":"Akiko Yagami","doi":"10.15036/arerugi.74.47","DOIUrl":"10.15036/arerugi.74.47","url":null,"abstract":"","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"74 2","pages":"47-51"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A 30-year-old man who had worked in the painting industry for the past year was referred to our hospital after developing progressive exertional dyspnea. A chest computed tomography scan showed a diffuse, random pattern of ground-glass opacities in the lungs. Bronchoalveolar lavage fluid (BALF) was predominantly lymphocytic (49.2%), and bronchoscopic cryobiopsy showed fibrotic interstitial proliferation around the small bronchi and Masson's bodies. The drug-induced lymphocyte stimulation test (DLST) for isocyanate (hexamethylene diisocyanate [HDI]) reagent was positive in blood and the BALF samples. The patient was diagnosed with hypersensitivity pneumonitis, and isocyanates (HDI) were suspected as the allergen based on the effectiveness of antigen avoidance, occupational history, DLST results, and a multidisciplinary discussion. Avoiding the antigen with a leave of absence and changing jobs, along with corticosteroids and mycophenolate mofetil treatment resulted in partial improvement of both the reticular shadows in the lungs and respiratory function. In recent years, isocyanate-induced hypersensitivity pneumonitis has become rare, probably because of improvements in working environments, but healthcare providers must still be aware of it as an occupational allergy. Although DLST alone cannot definitively diagnose hypersensitivity pneumonia, when combined with other findings it may serve as a useful adjunct diagnostic tool, as in this case.
{"title":"[A CASE OF FIBROTIC HYPERSENSITIVITY PNEUMONITIS IN WHICH A DRUG-INDUCED LYMPHOCYTE STIMULATION TEST FOR ISOCYANATE (HEXAMETHYLENE DIISOCYANATE) REAGENT WAS CONTRIBUTED TO DIAGNOSIS].","authors":"Yusuke Nakamura, Mizuki Inaba, Yuto Goto, Nana Yazawa, Nobuhiko Tsukada, Azusa Tsukada, Yuki Ooka, Hadzki Matsuda, Kazuyuki Ishida, Hiroaki Arakawa, Seiji Niho, Yasuo Shimizu","doi":"10.15036/arerugi.74.271","DOIUrl":"https://doi.org/10.15036/arerugi.74.271","url":null,"abstract":"<p><p>A 30-year-old man who had worked in the painting industry for the past year was referred to our hospital after developing progressive exertional dyspnea. A chest computed tomography scan showed a diffuse, random pattern of ground-glass opacities in the lungs. Bronchoalveolar lavage fluid (BALF) was predominantly lymphocytic (49.2%), and bronchoscopic cryobiopsy showed fibrotic interstitial proliferation around the small bronchi and Masson's bodies. The drug-induced lymphocyte stimulation test (DLST) for isocyanate (hexamethylene diisocyanate [HDI]) reagent was positive in blood and the BALF samples. The patient was diagnosed with hypersensitivity pneumonitis, and isocyanates (HDI) were suspected as the allergen based on the effectiveness of antigen avoidance, occupational history, DLST results, and a multidisciplinary discussion. Avoiding the antigen with a leave of absence and changing jobs, along with corticosteroids and mycophenolate mofetil treatment resulted in partial improvement of both the reticular shadows in the lungs and respiratory function. In recent years, isocyanate-induced hypersensitivity pneumonitis has become rare, probably because of improvements in working environments, but healthcare providers must still be aware of it as an occupational allergy. Although DLST alone cannot definitively diagnose hypersensitivity pneumonia, when combined with other findings it may serve as a useful adjunct diagnostic tool, as in this case.</p>","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"74 5","pages":"271-276"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145287429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[UPDATE ON FOOD ALLERGY].","authors":"Yuko Chinuki","doi":"10.15036/arerugi.74.257","DOIUrl":"https://doi.org/10.15036/arerugi.74.257","url":null,"abstract":"","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"74 5","pages":"257-262"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145287438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[SIGNIFICANCE OF DIGITAL BIOMARKERS IN ASTHMA AND ALLERGY MANAGEMENT].","authors":"Koichi Fukunaga","doi":"10.15036/arerugi.74.337","DOIUrl":"https://doi.org/10.15036/arerugi.74.337","url":null,"abstract":"","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"74 6","pages":"337-339"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145726408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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