Purpose: The research on macadamia nut oral food challenge (OFC) is limited. This study aimed to evaluate the clinical characteristics of macadamia nut OFC by evaluating data from our department.
Methods: This study retrospectively analyzed macadamia nut OFC data from medical record from January 2013 to June 2024, targeting loading doses of 1 gram and 10 grams. The relationships between OFC outcomes, patient demographics, and macadamia nut skin prick test (SPT) results were assessed.
Results: A total of 66 patients were included, with 33 patients in the 1 gram and 10 gram loading dose groups each. The OFC positivity was observed in 27% of patients at 1 gram and 12% at 10 grams. Among the positive cases, the anaphylaxis induction rates were 52% for the 1 gram group and 3% for the 10 gram group. Univariate analysis revealed that the macadamia nut SPT was not predictive of anaphylaxis. However, a history of immediate allergic reactions to macadamia nuts and the diameter of macadamia nut SPT swelling were associated with OFC positivity.
Conclusion: Macadamia nut OFC has the potential to induce severe allergic reactions, including anaphylaxis. Adequate preparation and precautionary measures should be put in place when conducting macadamia nut OFC to manage potential risks effectively.
{"title":"[A STUDY ON THE CLINICAL CHARACTERISTICS OF MACADAMIA NUT ORAL FOOD CHALLENGE].","authors":"Chihiro Kunigami, Takanori Imai, Kosei Yamashita, Megumi Okawa, Toshiyuki Takagi, Aiko Honda, Yuki Okada, Taro Kamiya","doi":"10.15036/arerugi.74.133","DOIUrl":"https://doi.org/10.15036/arerugi.74.133","url":null,"abstract":"<p><strong>Purpose: </strong>The research on macadamia nut oral food challenge (OFC) is limited. This study aimed to evaluate the clinical characteristics of macadamia nut OFC by evaluating data from our department.</p><p><strong>Methods: </strong>This study retrospectively analyzed macadamia nut OFC data from medical record from January 2013 to June 2024, targeting loading doses of 1 gram and 10 grams. The relationships between OFC outcomes, patient demographics, and macadamia nut skin prick test (SPT) results were assessed.</p><p><strong>Results: </strong>A total of 66 patients were included, with 33 patients in the 1 gram and 10 gram loading dose groups each. The OFC positivity was observed in 27% of patients at 1 gram and 12% at 10 grams. Among the positive cases, the anaphylaxis induction rates were 52% for the 1 gram group and 3% for the 10 gram group. Univariate analysis revealed that the macadamia nut SPT was not predictive of anaphylaxis. However, a history of immediate allergic reactions to macadamia nuts and the diameter of macadamia nut SPT swelling were associated with OFC positivity.</p><p><strong>Conclusion: </strong>Macadamia nut OFC has the potential to induce severe allergic reactions, including anaphylaxis. Adequate preparation and precautionary measures should be put in place when conducting macadamia nut OFC to manage potential risks effectively.</p>","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"74 3","pages":"133-138"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.15036/arerugi.74.s181
{"title":"[JSA WAO Symposium].","authors":"","doi":"10.15036/arerugi.74.s181","DOIUrl":"https://doi.org/10.15036/arerugi.74.s181","url":null,"abstract":"","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"74 Supple","pages":"s181-s182"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[ETIOLOGY AND CLINICAL FEATURES OF ATOPIC OCULAR COMPLICATIONS: CATARACT, RETINAL DETACHMENT, AND KERATOCONUS].","authors":"Meiko Kimura","doi":"10.15036/arerugi.74.185","DOIUrl":"10.15036/arerugi.74.185","url":null,"abstract":"","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"74 4","pages":"185-190"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ostrich antibodies have a cost advantage over antibodies derived from small animals and are commercially used in diagnostic reagents. They are also expected to be effective in preventing infection, and products containing them, such as cosmetics, are available on the market. We encountered two cases of egg allergy in adult women after using cosmetics containing ostrich egg yolk extract to which this antibody was applied. Case 1: a 44-year-old woman who consumed Japanese pizza with semi-cooked eggs and experienced eyelid swelling, abdominal pain, vomiting, urticaria, and dyspnea. Case 2: a 21-year-old woman who ate "oyakodon" (a chicken and egg dish) containing raw egg yolk, resulting in a cough, hoarseness, itching and hypotension. They had used cosmetics containing ostrich egg yolk extract for approximately five years and one year, respectively. Both patients had elevated egg yolk-specific IgE antibody titers, consistent with bird-egg syndrome, but neither had a history of bird breeding. In both cases, the results of prick tests for chicken egg white, egg yolk and the cosmetics they used were positive, and the basophil activation tests of the same cosmetic products were also positive. From these results, we speculated that the use of cosmetics containing ostrich egg yolk extract is possibly associated with their development of an egg allergy.
{"title":"[TWO CASES OF ADULT EGG ALLERGY THAT DEVELOPED AFTER USING COSMETIC PRODUCTS CONTAINING OSTRICH EGG YOLK EXTRACT].","authors":"Koki Okabe, Akiko Sugiyama, Takehito Fukushima, Reiko Kishikawa, Hiroshi Matsuzaki, Masashi Nakamura, Kayoko Matsunaga","doi":"10.15036/arerugi.74.94","DOIUrl":"https://doi.org/10.15036/arerugi.74.94","url":null,"abstract":"<p><p>Ostrich antibodies have a cost advantage over antibodies derived from small animals and are commercially used in diagnostic reagents. They are also expected to be effective in preventing infection, and products containing them, such as cosmetics, are available on the market. We encountered two cases of egg allergy in adult women after using cosmetics containing ostrich egg yolk extract to which this antibody was applied. Case 1: a 44-year-old woman who consumed Japanese pizza with semi-cooked eggs and experienced eyelid swelling, abdominal pain, vomiting, urticaria, and dyspnea. Case 2: a 21-year-old woman who ate \"oyakodon\" (a chicken and egg dish) containing raw egg yolk, resulting in a cough, hoarseness, itching and hypotension. They had used cosmetics containing ostrich egg yolk extract for approximately five years and one year, respectively. Both patients had elevated egg yolk-specific IgE antibody titers, consistent with bird-egg syndrome, but neither had a history of bird breeding. In both cases, the results of prick tests for chicken egg white, egg yolk and the cosmetics they used were positive, and the basophil activation tests of the same cosmetic products were also positive. From these results, we speculated that the use of cosmetics containing ostrich egg yolk extract is possibly associated with their development of an egg allergy.</p>","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"74 2","pages":"94-97"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号