{"title":"[EPIDEMIOLOGY THE CAUSAL RELATIONSHIP BETWEEN ENVIRONMENT AND ALLERGY DEVELOPMENT: INSIGHTS FROM EPIDEMIOLOGICAL STUDIES].","authors":"Kiwako Yamamoto-Hanada, Yukihiro Ohya","doi":"10.15036/arerugi.74.11","DOIUrl":"https://doi.org/10.15036/arerugi.74.11","url":null,"abstract":"","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"74 1","pages":"11-19"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[GUIDELINES FOR MOLECULAR TARGETED THERAPY IN COMPREHENSIVE ALLERGY PRACTICE 2025].","authors":"Hiroyuki Nagase","doi":"10.15036/arerugi.74.31","DOIUrl":"https://doi.org/10.15036/arerugi.74.31","url":null,"abstract":"","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"74 2","pages":"31-35"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[ENVIRONMENTAL FACTORS AND OCCUPATIONAL ALLERGIC DISEASES -TRENDS, DIAGNOSIS AND TREATMENT WITH A FOCUS ON OCCUPATIONAL ASTHMA].","authors":"Takeshi Hisada","doi":"10.15036/arerugi.74.114","DOIUrl":"https://doi.org/10.15036/arerugi.74.114","url":null,"abstract":"","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"74 3","pages":"114-118"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We present a case of a 9-year-old girl with pork-cat syndrome (PCS) who experienced repeated episodes of urticaria and gastrointestinal symptoms after ingesting pork, beef, and milk since she was 7 years old. Her family has had a cat since she was born. Antigen-specific IgE tests showed high values against Fel d 1, Fel d 2, Sus s 1, Bos d 6, beef, pork, milk, dog dander, and cat dander. However, an antigen-specific IgE test performed in infancy was negative for cow's milk. The skin prick test was positive for raw pork, raw beef, and milk, but these reactions were attenuated by heating. Immunoblot analysis showed that the patient's serum IgE bound to a protein in pork that had the same molecular weight (67kDa) as cat dander extracts, and also cross-reactivity between these two proteins was confirmed by an inhibition test, leading to the diagnosis of PCS. Similar cross-reactivity was confirmed for beef, milk, and cat dander extracts. We experienced a case of PCS, in which allergies to cow's milk appeared not only due to meat such as pork and beef, but also to cow's milk sensitized by the rearing of cats.
{"title":"[PORK-CAT SYNDROME WITH ALLERGIC SYMPTOMS DUE TO THE INGESTION OF COW'S MILK].","authors":"Reiko Takewa, Yuko Chinuki, Yoshiaki Harada, Makiko Nakamura, Shinsaku Hayashi, Shoichiro Taniuchi","doi":"10.15036/arerugi.74.89","DOIUrl":"https://doi.org/10.15036/arerugi.74.89","url":null,"abstract":"<p><p>We present a case of a 9-year-old girl with pork-cat syndrome (PCS) who experienced repeated episodes of urticaria and gastrointestinal symptoms after ingesting pork, beef, and milk since she was 7 years old. Her family has had a cat since she was born. Antigen-specific IgE tests showed high values against Fel d 1, Fel d 2, Sus s 1, Bos d 6, beef, pork, milk, dog dander, and cat dander. However, an antigen-specific IgE test performed in infancy was negative for cow's milk. The skin prick test was positive for raw pork, raw beef, and milk, but these reactions were attenuated by heating. Immunoblot analysis showed that the patient's serum IgE bound to a protein in pork that had the same molecular weight (67kDa) as cat dander extracts, and also cross-reactivity between these two proteins was confirmed by an inhibition test, leading to the diagnosis of PCS. Similar cross-reactivity was confirmed for beef, milk, and cat dander extracts. We experienced a case of PCS, in which allergies to cow's milk appeared not only due to meat such as pork and beef, but also to cow's milk sensitized by the rearing of cats.</p>","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"74 2","pages":"89-93"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A 74-year-old man was treated with nintedanib for idiopathic pulmonary fibrosis (IPF). Thirty-six days after starting to take nintedanib, he admitted to our hospital due to respiratory failure with ground-glass opacities and mediastinal emphysema on chest CT. Acute exacerbation of IPF was suspected. Because lung injury due to nintedanib was suspected, nintedanib was discontinued. Although he was treated with pulse corticosteroid therapy, interstitial pneumonia and mediastinal emphysema deteriorated. Despite continuing corticosteroid therapy, he died 21 days after admission due to respiratory failure. Subsequently drug lymphocyte stimulation test for nintedanib was found to be positive. We should pay attention to possibility of drug-induced lung injury caused by nintedanib.
{"title":"[A CASE OF IDIOPATHIC PULMONARY FIBROSIS WITH SUSPECTED DRUG-INDUCED LUNG INJURY FOLLOWING ACUTE EXACERBATION AFTER NINTEDANIB ADMINISTRATION].","authors":"Toshiyuki Yonezawa, Shiori Nishizaki, Hitomi Kako, Hitomi Amano, Hiroto Murao, Masaya Fukami, Tomoyuki Ogisu, Takuma Katano, Satoru Ito","doi":"10.15036/arerugi.74.83","DOIUrl":"https://doi.org/10.15036/arerugi.74.83","url":null,"abstract":"<p><p>A 74-year-old man was treated with nintedanib for idiopathic pulmonary fibrosis (IPF). Thirty-six days after starting to take nintedanib, he admitted to our hospital due to respiratory failure with ground-glass opacities and mediastinal emphysema on chest CT. Acute exacerbation of IPF was suspected. Because lung injury due to nintedanib was suspected, nintedanib was discontinued. Although he was treated with pulse corticosteroid therapy, interstitial pneumonia and mediastinal emphysema deteriorated. Despite continuing corticosteroid therapy, he died 21 days after admission due to respiratory failure. Subsequently drug lymphocyte stimulation test for nintedanib was found to be positive. We should pay attention to possibility of drug-induced lung injury caused by nintedanib.</p>","PeriodicalId":35521,"journal":{"name":"Japanese Journal of Allergology","volume":"74 2","pages":"83-88"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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