Maja Mizdrak, Tina Tičinović Kurir, Ivan Mizdrak, I. Jerković, Ante Mayer
Given high risk of infection-related mortality due to impaired immunity, elderly patients are at increased risk with COVID-19. In its diagnostic procedure clinical laboratory medicine has a pivotal role. The aim of this study was to investigate clinical and laboratory specificities in Croatian population of nursing home residents affected by coronavirus. One hundred and six residents of nursing homes that were hospitalized due to COVID-19 infection, were included in this retrospective study. Clinical and laboratory findings at three time points were extracted from medical records. There were 86 females and 20 males, with median of age 84 (min-max: 47–97) years. Patients were divided into three groups: Survivors (S), patients who are still alive (N=65), In-Hospital Non-Survivors (IHNS), patients who died from coronavirus during hospitalization (N=31) and Out-of-Hospital Non-Survivors (OHNS), patients who recovered from infection but died during the period of three months of the follow-up (N=10). We have established differences between these three groups in laboratory findings (p<0.05). At the admission, survivors had lower values of lactate dehydrogenase, aspartate transaminase, sedimentation ratio, ferritin and C-reactive protein, OHNS were in the middle, and IHNS had the highest values. Leukocytes and absolute lymphocyte count were greater in OHNS group, and same between survivors and IHNS. After 7 days, we noticed increase in leukocyte and neutrophils count among IHNS. Assessing of complete blood count, differential blood count, reactants of acute infection and combination of their ratios might predict worse outcome in nursing home residents due to coronavirus infection.
{"title":"Characteristics of COVID-19 Infection among Nursing Home Residents","authors":"Maja Mizdrak, Tina Tičinović Kurir, Ivan Mizdrak, I. Jerković, Ante Mayer","doi":"10.5671/CA.44.4.4","DOIUrl":"https://doi.org/10.5671/CA.44.4.4","url":null,"abstract":"Given high risk of infection-related mortality due to impaired immunity, elderly patients are at increased risk with COVID-19. In its diagnostic procedure clinical laboratory medicine has a pivotal role. The aim of this study was to investigate clinical and laboratory specificities in Croatian population of nursing home residents affected by coronavirus. One hundred and six residents of nursing homes that were hospitalized due to COVID-19 infection, were included in this retrospective study. Clinical and laboratory findings at three time points were extracted from medical records. There were 86 females and 20 males, with median of age 84 (min-max: 47–97) years. Patients were divided into three groups: Survivors (S), patients who are still alive (N=65), In-Hospital Non-Survivors (IHNS), patients who died from coronavirus during hospitalization (N=31) and Out-of-Hospital Non-Survivors (OHNS), patients who recovered from infection but died during the period of three months of the follow-up (N=10). We have established differences between these three groups in laboratory findings (p<0.05). At the admission, survivors had lower values of lactate dehydrogenase, aspartate transaminase, sedimentation ratio, ferritin and C-reactive protein, OHNS were in the middle, and IHNS had the highest values. Leukocytes and absolute lymphocyte count were greater in OHNS group, and same between survivors and IHNS. After 7 days, we noticed increase in leukocyte and neutrophils count among IHNS. Assessing of complete blood count, differential blood count, reactants of acute infection and combination of their ratios might predict worse outcome in nursing home residents due to coronavirus infection.","PeriodicalId":35544,"journal":{"name":"Collegium Antropologicum","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47074867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of the paper is to develop a model of changes in morphological characteristics of young males and females body structure at the beginning of the 21st century. For this purpose the results of Moscow students’ annual screenings from 2000 to 2018 were analyzed (total number of 17–18-year-olds − 6,433 individuals). As a result, five factors describing the trends of changes were revealed and further analysis demonstrated variants of their values over time. An original model was developed, which reflected real morphological transformations in the body parameters of the young generation for the last 20 years. For both sex groups a trend towards macrosomia (gr. macros − big, soma- body) was revealed. For the boys some increase in linear traits was found with a decrease in muscularity. In girls, parabolic association between athletic characteristics and the year of investigation was found: the decrease in muscularity for the first decade, and its increase for the second one.
{"title":"Model-Based Analysis of Changes in the Morphological Characteristics of Moscow Students for the Last Two Decades","authors":"M. Negasheva, S. Zimina, I. Sineva, E. Godina","doi":"10.5671/CA.44.4.5","DOIUrl":"https://doi.org/10.5671/CA.44.4.5","url":null,"abstract":"The aim of the paper is to develop a model of changes in morphological characteristics of young males and females body structure at the beginning of the 21st century. For this purpose the results of Moscow students’ annual screenings from 2000 to 2018 were analyzed (total number of 17–18-year-olds − 6,433 individuals). As a result, five factors describing the trends of changes were revealed and further analysis demonstrated variants of their values over time. An original model was developed, which reflected real morphological transformations in the body parameters of the young generation for the last 20 years. For both sex groups a trend towards macrosomia (gr. macros − big, soma- body) was revealed. For the boys some increase in linear traits was found with a decrease in muscularity. In girls, parabolic association between athletic characteristics and the year of investigation was found: the decrease in muscularity for the first decade, and its increase for the second one.","PeriodicalId":35544,"journal":{"name":"Collegium Antropologicum","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41995661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Jelenc, M. Vidovič, Edit Marosi, P. Nagy, A. Federici, Mateja Lam
In the literature in the field of cancer care, especially in the literature concerning national cancer control programmes, the terms governance and stewardship in/of cancer care are used, but usually not explained or defined. Therefore, we planned a systematic literature review in order to find the definitions of the terms governance and stewardship in/of cancer care. It was planned to create new definitions of the mentioned terms in case of unsuccessful finds. A literature review using PubMed, Google and MeSH as well as an opportunistic search for extra articles and chapters from books and grey literature was performed. Most of the found and analysed articles did not give exact explanation of the terms governance/stewardship in/of cancer care or they cited older articles (published before the year 2000) where the terms are used mostly in the field of clinical governance or in the completely other fileds, mostly banking, economy, religion or spirituality. Therefore, it was decided in the working group of experts from different European countries collaborating within in the work package Governance of integrated and comprehensive cancer care in the frame of the Innovative Partnership for the Action Against Cancer Joint Action project on cancer to create new definitions which we are presenting for the first time. The new definitions will facilitate the understanding of the leadership tasks in the area of cancer care and cancer control and will be particularly useful in the field of cancer programmes.
{"title":"Governance in/of Cancer Care and Stewardship in Cancer Control","authors":"M. Jelenc, M. Vidovič, Edit Marosi, P. Nagy, A. Federici, Mateja Lam","doi":"10.5671/CA.44.4.7","DOIUrl":"https://doi.org/10.5671/CA.44.4.7","url":null,"abstract":"In the literature in the field of cancer care, especially in the literature concerning national cancer control programmes, the terms governance and stewardship in/of cancer care are used, but usually not explained or defined. Therefore, we planned a systematic literature review in order to find the definitions of the terms governance and stewardship in/of cancer care. It was planned to create new definitions of the mentioned terms in case of unsuccessful finds. A literature review using PubMed, Google and MeSH as well as an opportunistic search for extra articles and chapters from books and grey literature was performed. Most of the found and analysed articles did not give exact explanation of the terms governance/stewardship in/of cancer care or they cited older articles (published before the year 2000) where the terms are used mostly in the field of clinical governance or in the completely other fileds, mostly banking, economy, religion or spirituality. Therefore, it was decided in the working group of experts from different European countries collaborating within in the work package Governance of integrated and comprehensive cancer care in the frame of the Innovative Partnership for the Action Against Cancer Joint Action project on cancer to create new definitions which we are presenting for the first time. The new definitions will facilitate the understanding of the leadership tasks in the area of cancer care and cancer control and will be particularly useful in the field of cancer programmes.","PeriodicalId":35544,"journal":{"name":"Collegium Antropologicum","volume":"44 1","pages":"239-243"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46403864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This paper will give a historical account of breastfeeding and explain the socio-cultural context in which the shift from breastfeeding to bottle feeding occurred in the western industrialized nations in the course of the nineteenth and twentieth centuries. Whereas in the nineteenth century most infants were breastfed by the middle of the twentieth century bottle-feeding had become the norm. The growth of artificial infant feeding was related to economic conditions as well as the socio- cultural changes within the burgeoning industrial societies. Aside from the rise of infant formula industry one of the major factors that affected the decline in breastfeeding rates was the shift of breastfeeding from a natural practice into an object of medicine and science. Other cultural factors including religious beliefs, feminism and the changing roles of women within society have affected women's infant feeding choices. Throughout these socio-historical developments breastfeeding was promoted as the best option for infant health. However, concern over breastfeeding rates was also a concern over women's proper mothering behavior and a desire to control women and their mothering practices.
{"title":"The Socio-Cultural Context of Breastfeeding in the Nineteenth and Twentieth Centuries","authors":"Anđela Runjić Babić","doi":"10.5671/CA.44.4.8","DOIUrl":"https://doi.org/10.5671/CA.44.4.8","url":null,"abstract":"This paper will give a historical account of breastfeeding and explain the socio-cultural context in which the shift from breastfeeding to bottle feeding occurred in the western industrialized nations in the course of the nineteenth and twentieth centuries. Whereas in the nineteenth century most infants were breastfed by the middle of the twentieth century bottle-feeding had become the norm. The growth of artificial infant feeding was related to economic conditions as well as the socio- cultural changes within the burgeoning industrial societies. Aside from the rise of infant formula industry one of the major factors that affected the decline in breastfeeding rates was the shift of breastfeeding from a natural practice into an object of medicine and science. Other cultural factors including religious beliefs, feminism and the changing roles of women within society have affected women's infant feeding choices. Throughout these socio-historical developments breastfeeding was promoted as the best option for infant health. However, concern over breastfeeding rates was also a concern over women's proper mothering behavior and a desire to control women and their mothering practices.","PeriodicalId":35544,"journal":{"name":"Collegium Antropologicum","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48082990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katarina Mišković Špoljarić, Marijana Jukić, Teuta Opačak-Bernardi, L. Glavaš‐Obrovac
Traditional two dimensional cell culture has enabled great strides in biomedicine but needs to be improved to be able to keep up with the demands of modern biomedical research. 2D monolayer culture cannot replicate tissue responses and needs to be supplemented with extensive animal research. Growing cells in three dimensional scaffolds provides a more functional model for biomedical research than traditional monolayer culture. Depending on the needs and the complexity of the model there are several ways that 3D models can be initiated. Simple spheroids can be grown in low adherence plates and in hanging drops while larger spheroids and co-cultured ones need to be grown in systems with greater support such as hydro gels. The system that offers the greatest flexibility is the magnetic levitation approach. In the paper we offer a brief resume to various 3D methods and their characteristics to ease the choice of methods for implementing 3D cell culture techniques .
{"title":"3D Cell Technology in Biomedical Research","authors":"Katarina Mišković Špoljarić, Marijana Jukić, Teuta Opačak-Bernardi, L. Glavaš‐Obrovac","doi":"10.5671/ca.44.3.10","DOIUrl":"https://doi.org/10.5671/ca.44.3.10","url":null,"abstract":"Traditional two dimensional cell culture has enabled great strides in biomedicine but needs to be improved to be able to keep up with the demands of modern biomedical research. 2D monolayer culture cannot replicate tissue responses and needs to be supplemented with extensive animal research. Growing cells in three dimensional scaffolds provides a more functional model for biomedical research than traditional monolayer culture. Depending on the needs and the complexity of the model there are several ways that 3D models can be initiated. Simple spheroids can be grown in low adherence plates and in hanging drops while larger spheroids and co-cultured ones need to be grown in systems with greater support such as hydro gels. The system that offers the greatest flexibility is the magnetic levitation approach. In the paper we offer a brief resume to various 3D methods and their characteristics to ease the choice of methods for implementing 3D cell culture techniques .","PeriodicalId":35544,"journal":{"name":"Collegium Antropologicum","volume":"44 1","pages":"171-174"},"PeriodicalIF":0.0,"publicationDate":"2020-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42591772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Irina Bagić, D. Mužević, Gordan Reljac, Vjenceslav Vrtarić, M. Kovačević
Aneurysmal bone cyst (ABC) is a non-neoplastic locally destructive primary bone lesion mostly occurring within the first two decades of life with female predominance. Cervical spine ABCs are a very rare clinical entity with particularly demanding surgical resection limited by the involvement of nearby neurovascular structures and a risk for cervical spine instability. We present a case of a 17-year-old patient with a symptomatic ABC of the cervical spine who underwent surgical removal of the osseous lesion with good postoperative outcome. There are different therapeutic strategies for ABC management, but complete surgical removal of the cyst remains one of the most important predictors of favorable outcome, although it can be often limited, especially in the cervical region. Previously described lesions have a very high recurrence rate and therefore different additional methods, such as radiotherapy, embolization and sclerosation have been used in addition to surgical resection. Further studies are necessary for development of evidence-based treatment regimens for cervical spine ABCs in pediatric population.
{"title":"Aneurysmal Bone Cyst of the Cervical Spine","authors":"Irina Bagić, D. Mužević, Gordan Reljac, Vjenceslav Vrtarić, M. Kovačević","doi":"10.5671/ca.44.3.8","DOIUrl":"https://doi.org/10.5671/ca.44.3.8","url":null,"abstract":"Aneurysmal bone cyst (ABC) is a non-neoplastic locally destructive primary bone lesion mostly occurring within the first two decades of life with female predominance. Cervical spine ABCs are a very rare clinical entity with particularly demanding surgical resection limited by the involvement of nearby neurovascular structures and a risk for cervical spine instability. We present a case of a 17-year-old patient with a symptomatic ABC of the cervical spine who underwent surgical removal of the osseous lesion with good postoperative outcome. There are different therapeutic strategies for ABC management, but complete surgical removal of the cyst remains one of the most important predictors of favorable outcome, although it can be often limited, especially in the cervical region. Previously described lesions have a very high recurrence rate and therefore different additional methods, such as radiotherapy, embolization and sclerosation have been used in addition to surgical resection. Further studies are necessary for development of evidence-based treatment regimens for cervical spine ABCs in pediatric population.","PeriodicalId":35544,"journal":{"name":"Collegium Antropologicum","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43880862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Human behavior is governed by concepts. Concepts are cognitive representations of reality. Cognitive linguistics suggests that there are cognitive models affecting the formation of concepts in human mind, such as cognitive metaphor and a prototype model. We used the example of an ancient procedure – trepanation in order to show the connection between the procedure and the concept of the skull as a container, which is a metaphor. Most important concepts in medical systems are health and disease. There is no agreement about their exact definition, although there have been many studies focusing on that. Based on the previous research, we suggest possible benefits from approaching the disease as a prototype category. In all studies so far there have always been consistencies in rating entities qualifying as a disease which is a feature of a prototype category – membership gradience. Entities perceived as diseases by respondents in studies so far have not been the same, but they share certain features. It is more likely for an entity to be considered a disease if it can lead to death, for example. In our opinion there are common core features determining disease as a cognitive category. Further cross-cultural studies could answer what features an entity needs to have in order to be considered a disease.Stressing such features could improve patients’cooperation when a new disease appears.
{"title":"Health-Related Concepts and Cognitive Linguistics","authors":"M. Raguž, Marijan Jukic, H. Roguljić","doi":"10.5671/ca.44.3.12","DOIUrl":"https://doi.org/10.5671/ca.44.3.12","url":null,"abstract":"Human behavior is governed by concepts. Concepts are cognitive representations of reality. Cognitive linguistics suggests that there are cognitive models affecting the formation of concepts in human mind, such as cognitive metaphor and a prototype model. We used the example of an ancient procedure – trepanation in order to show the connection between the procedure and the concept of the skull as a container, which is a metaphor. Most important concepts in medical systems are health and disease. There is no agreement about their exact definition, although there have been many studies focusing on that. Based on the previous research, we suggest possible benefits from approaching the disease as a prototype category. In all studies so far there have always been consistencies in rating entities qualifying as a disease which is a feature of a prototype category – membership gradience. Entities perceived as diseases by respondents in studies so far have not been the same, but they share certain features. It is more likely for an entity to be considered a disease if it can lead to death, for example. In our opinion there are common core features determining disease as a cognitive category. Further cross-cultural studies could answer what features an entity needs to have in order to be considered a disease.Stressing such features could improve patients’cooperation when a new disease appears.","PeriodicalId":35544,"journal":{"name":"Collegium Antropologicum","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43072196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart failure with reduced ejection fraction (HFrEF) is a progressive clinical syndrome defined by changes in the myocardial structure, which lead to predominant systolic myocardial function impairment, with a left ventricle ejection of fraction ≤40%. The rehospitalization burden in HFrEF patients (pts) remains very high, with poor quality of life, increased mortality and large healthcare expenditures. In this research project, we investigated the risk factors for first and repeated hospitalization in pts with HFrEF. This retrospective study included 50 adult pts with a diagnosis of HFrEF and who were within the age range of 55 to 89 years old and of both sexes. Demographic and clinical data (HFrEF etiology, renal function parameters, complete blood count, markers of inflammation, electrocardiogram, troponin I, NTproBNP, echocardiographic parameters and comorbidities data) were collected from the pts’ medical histories. Statistical analysis was performed via Fischer’s exact test, the Shapiro-Wilk test and the Spearman correlation coefficient. This study included 70% male and 30% female HFrEF pts. Males were younger in both group of pts and had a higher incidence of rehospitalization. The most important HFrEF etiologic risk factors are arterial hypertension (82%), coronary heart disease (54%), atrial fibrillation (52%) and diabetes mellitus (40%). The most important noncardiac comorbidity related with the first HFrEF hospitalization is pneumonia (P=0.03), while progression of left ventricle systolic and diastolic dysfunction is related to rehospitalization risk (left ventricle end systolic diameter, P=0.003; diastolic dysfunction degree, P=0.04). The troponin level was associated with an increased risk of rehospitalization, but this was not statistically significant at this sample size (troponin I, p=0.10). Following the first and repeated hospitalizations of HFrEF pts, comorbidities, ageing and gender difference are crucial to HFrEF development, while echocardiographic parameters and biomarkers critically affect HFrEF rehospitalization risk.
{"title":"Prognostički pokazatelji prve i\u0000ponovljene hospitalizacije kod pacijenata sa srčanim zatajivanjem s reduciranom\u0000ejekcijskom frakcijom lijeve klijetke","authors":"Kristina Selthofer-Relatić, Jure Mirat, Kristina Kralik, Jadranka Arambašić, Anto Stažić, Matko Tomić","doi":"10.5671/ca.44.3.5","DOIUrl":"https://doi.org/10.5671/ca.44.3.5","url":null,"abstract":"Heart failure with reduced ejection fraction (HFrEF) is a progressive clinical syndrome defined by changes in the myocardial structure, which lead to predominant systolic myocardial function impairment, with a left ventricle ejection of fraction ≤40%. The rehospitalization burden in HFrEF patients (pts) remains very high, with poor quality of life, increased mortality and large healthcare expenditures. In this research project, we investigated the risk factors for first and repeated hospitalization in pts with HFrEF. This retrospective study included 50 adult pts with a diagnosis of HFrEF and who were within the age range of 55 to 89 years old and of both sexes. Demographic and clinical data (HFrEF etiology, renal function parameters, complete blood count, markers of inflammation, electrocardiogram, troponin I, NTproBNP, echocardiographic parameters and comorbidities data) were collected from the pts’ medical histories. Statistical analysis was performed via Fischer’s exact test, the Shapiro-Wilk test and the Spearman correlation coefficient. This study included 70% male and 30% female HFrEF pts. Males were younger in both group of pts and had a higher incidence of rehospitalization. The most important HFrEF etiologic risk factors are arterial hypertension (82%), coronary heart disease (54%), atrial fibrillation (52%) and diabetes mellitus (40%). The most important noncardiac comorbidity related with the first HFrEF hospitalization is pneumonia (P=0.03), while progression of left ventricle systolic and diastolic dysfunction is related to rehospitalization risk (left ventricle end systolic diameter, P=0.003; diastolic dysfunction degree, P=0.04). The troponin level was associated with an increased risk of rehospitalization, but this was not statistically significant at this sample size (troponin I, p=0.10). Following the first and repeated hospitalizations of HFrEF pts, comorbidities, ageing and gender difference are crucial to HFrEF development, while echocardiographic parameters and biomarkers critically affect HFrEF rehospitalization risk.","PeriodicalId":35544,"journal":{"name":"Collegium Antropologicum","volume":"44 1","pages":"139-145"},"PeriodicalIF":0.0,"publicationDate":"2020-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48848648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}