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Delayed Childhood Immunization and its Associated Factors in Children under 2 Years of Age in Kelambakkam, Chengalpattu District Chengalpattu区Kelambakkam 2岁以下儿童延迟免疫及其相关因素
Q4 Medicine Pub Date : 2022-09-30 DOI: 10.24321/0019.5138.202287
Raja D
Introduction: Immunisation is the most effective public health intervention for reducing morbidity and mortality among young children. Even though we have witnessed an increase in immunization status, the lag in vaccinating younger children and the rural-urban gap in immunizing kids is still a matter of concern. Any disruption in the ongoing immunization services might even contribute to the initiation of the secondary outbreak of vaccine-preventable diseases. Methodology: A cross-sectional study was conducted to assess the immunization status of children under 2 years of age in Kelambakkam, along with the determinants of missed/delayed immunization using a semi-structured questionnaire to the parents of children below 2 years of age residing in Kelambakkam area of Chengalpattu district. Results: Delay in immunization was recorded in 34.28% of children among the entire study participants. Vaccines like MR1 (Measles, Rubella), and PCV Booster given at 9 months were delayed in 25% of children. Immunization delay and birth order of the baby were found to be significantly associated with each other. Conclusion: The delivery of basic health services like childhood immunization in Chengalpattu was majorly disrupted due to the ongoing pandemic. The findings of our study may be considered a basic reference for implementing any plan of action to improve childhood vaccination coverage during an epidemic or natural disaster or pandemic.
引言:免疫接种是降低幼儿发病率和死亡率的最有效的公共卫生干预措施。尽管我们目睹了免疫接种状况的提高,但为年幼儿童接种疫苗的滞后以及为儿童接种疫苗方面的城乡差距仍然令人担忧。正在进行的免疫服务的任何中断甚至可能导致疫苗可预防疾病的二次爆发。方法:对居住在Chengalpattu区Kelambakkam地区的2岁以下儿童的父母进行了一项半结构化问卷调查,以评估Kelambakam 2岁以下的儿童的免疫状况,以及错过/延迟免疫的决定因素。结果:在整个研究参与者中,34.28%的儿童出现了免疫延迟。25%的儿童在9个月时延迟接种MR1(麻疹、风疹)和PCV加强针等疫苗。免疫接种延迟和婴儿出生顺序之间存在显著相关性。结论:由于持续的疫情,Chengalpattu的儿童免疫等基本卫生服务的提供受到了严重干扰。我们的研究结果可被视为在流行病、自然灾害或大流行病期间实施任何提高儿童疫苗接种覆盖率的行动计划的基本参考。
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引用次数: 0
Antimalarial Activity of the Crude Extract and Solvent Fractions of the Stem of Momordica Charantia in Plasmodium Berghei Infected Mice 苦瓜茎粗提物和溶剂组分对伯氏疟原虫感染小鼠的抗疟活性
Q4 Medicine Pub Date : 2022-09-30 DOI: 10.24321/0019.5138.202288
Akwu Bp
ntroduction:The emergence and rapid spread of multidrug-resistant Plasmodium strains, especially Plasmodium falciparum, has become a major concern for health professionals when it comes to malaria prophylaxis and treatment, limiting medication options, necessitating the search for new antimalarial drugs derived from plants. In mice infected with Plasmodium berghei, the antimalarial function of Momordica charantia stem crude methanolic extract and solvent fractions (hexane, ethyl acetate, and aqueous) was examined. Method:Starting on the day the infection was identified, the extract and fractions were administered continuously for four days. Tween 80 (0.3 ml) was given to the control group, while the standard reference drugs were chloroquine (10 mg/kgbw) and arteether (3 mg/kgbw) which were given for three days. The crude extract and fractions were tested for antimalarial activity in Plasmodium berghei infected mice using a four-day suppressive test. Result: At 500 mg/kgbw, the crude extract, hexane fraction, ethyl acetate fraction, and aqueous fraction developed 80.62, 90.09, 91.23, and 81.72 per cent chemosuppression respectively, on day 6 after infection. Chemosuppression was 100% for chloroquine and 90% for arteether. Conclusion: These results showed that the crude extract and solvent fractions of Momordica charantia stem had antiplasmodial efficacy comparable to the reference drug, indicating that the plant could be used as a natural antimalarial agent.
简介:耐多药疟原虫株,特别是恶性疟原虫的出现和迅速传播,已成为卫生专业人员在疟疾预防和治疗方面的一个主要问题,限制了药物选择,需要寻找从植物中提取的新的抗疟药物。在感染伯氏疟原虫的小鼠中,检测了苦瓜茎粗甲醇提取物和溶剂组分(己烷、乙酸乙酯和水溶液)的抗疟功能。方法:从确定感染的当天开始,连续给药提取物和级分四天。对照组给药吐温80(0.3ml),标准对照药为氯喹(10mg/kgbw)和arteether(3mg/kgbw),给药三天。使用为期四天的抑制试验测试粗提取物和级分在伯氏疟原虫感染的小鼠中的抗疟活性。结果:在500 mg/kg体重下,感染后第6天,粗提取物、己烷组分、乙酸乙酯组分和水性组分分别产生80.62%、90.09、91.23%和81.72%的化学抑制。氯喹和乙醚的化学抑制率分别为100%和90%。结论:苦瓜茎的粗提物和溶剂组分具有与参比药物相当的抗疟效果,表明该植物可作为一种天然抗疟剂。
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引用次数: 1
Role of Pyrethroid-elicited Mosquito Behaviour in Control Programmes 拟除虫菊酯引起的蚊子行为在控制计划中的作用
Q4 Medicine Pub Date : 2022-09-30 DOI: 10.24321/0019.5138.202293
Renu Gupta
This review study envisages the role of insecticide-elicited mosquito behaviour for disease eradication programmes. Changes in behaviour due to insecticides may, at times, be of more practical importance than the actual lethal effect of the insecticide, especially if these changes help to disrupt the contact between man and mosquito. Two important aspects of mosquito behaviour, either repellency or irritability and biting patterns in response to insecticide exposure have been taken into consideration. This paper throws light on the significance of two synthetic pyrethroids, permethrin and deltamethrin, when impregnated into mosquito nets for self-protection and vector control. The determination of any changes with respect to behaviour of mosquitoes, before and after the introduction of bed nets is reflected in the potential of the mosquitoes to transmit diseases and can be of great epidemiological significance in mosquito abatement programmes.
这项审查研究设想了杀虫剂引发的蚊子行为在消灭疾病方案中的作用。杀虫剂引起的行为变化有时可能比杀虫剂的实际致死效果更具实际意义,尤其是如果这些变化有助于破坏人与蚊子之间的接触。考虑到了蚊子行为的两个重要方面,即排斥性或易激惹性以及对杀虫剂暴露的叮咬模式。本文阐明了两种合成拟除虫菊酯,氯氰菊酯和溴氰菊酯,在蚊帐中浸渍时对自我保护和媒介控制的重要性。在使用蚊帐之前和之后,确定蚊子行为的任何变化都反映在蚊子传播疾病的潜力上,这在减蚊方案中具有重要的流行病学意义。
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引用次数: 0
KFD-Present State of Knowledge KFD知识现状
Q4 Medicine Pub Date : 2022-09-30 DOI: 10.24321/0019.5138.202294
P. Rajagopalan
Leland B. Yeager believes that armchair theorizing is more than just the “simple sterile juggling of arbitrary assumptions” that occurs in the absence of fieldwork or the conventional scientific process. The scientific approach, which requires active examination of nature through data collection, contrasts with armchair scholarship. Even if an empirical scientist and an armchair philosopher use distinct methodologies, they might work together to uncover new facts or insights. The anthropologist Bronislaw Malinowski was a vocal opponent of armchair theory, and his ideas are frequently summed up by the phrase “get off the verandah.” Encouraging fieldwork and observation. There are hundreds of publications on Kyasanur Forest Disease during the last several decades, mostly from data already published, a computer analyzed and dished out with fancy titles. It never mattered to science.” I have been trying to tell the same thing to our Indian colleagues, particularly during the last two or more decades, who are wedded to theorizing from stale data collected by others and stored in computers.
Leland B.Yeager认为,纸上谈兵的理论不仅仅是在没有实地调查或传统科学过程的情况下发生的“简单而乏味的任意假设杂耍”。科学方法需要通过数据收集对自然进行积极的研究,这与纸上谈兵的学术形成了鲜明对比。即使实证科学家和纸上谈兵的哲学家使用不同的方法论,他们也可能合作发现新的事实或见解。人类学家Bronislaw Malinowski是纸上谈兵理论的强烈反对者,他的思想经常被总结为“滚出阳台”这句话。鼓励实地调查和观察。在过去的几十年里,有数百篇关于Kyasanur森林病的出版物,大多来自已经发表的数据,这些数据是经过计算机分析并以花哨的标题发布的。这对科学来说从来都不重要。”我一直试图告诉我们的印度同事同样的事情,特别是在过去的二十多年里,他们执着于根据他人收集并存储在计算机中的陈旧数据进行理论推导。
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引用次数: 0
Assessing the Quality of the Life of Lymphatic Filariasis Patients with Elephantoid Legs in a Post Mass Drug Administration (MDA) Phase Residing in Cherthala Taluk, Alappuzha 阿拉普扎Cherthala Taluk地区大象腿淋巴丝虫病患者在大规模给药(MDA)后阶段的生活质量评估
Q4 Medicine Pub Date : 2022-09-30 DOI: 10.24321/0019.5138.202286
T. Joy
Introduction: Elephantoid legs due to past LF infection are common in Cherthala, Alappuzha, Kerala. The physical disability refers to impairment of bodily functions and difficulties in performing daily chores. The study aims to assess the quality of life of filarial patients in the post MDA phase. Objectives: To assess the quality of life of lymphatic filariasis patients in the post MDA phase. Methodology: A cross sectional study was conducted at Thaickal and Chethy Panchayats of Cherthala through health camps with the help of the Accedited social health activists (ASHAs). People with lymphoedema living in these areas were considered eligible for the study after taking their consent. 114 chronic filarial patients were recruited for the study employing a validated questionnaire; Lymphatic Filariasis Specific Quality of Life Questionnaire (LFSQQ). The domain scores were expressed as mean with standard deviation. An independent t-test was used to compare the mean scores among various groups based on demographic characters. Results: Among the 7 domains,the least score was for the mobility domain indicating that mobility was the major concern affecting in their quality of life. The highest domain score was observed in the Psychological Health domain indicating that they have mentally adjusted to this condition. Conclusion: In the present study to assess the quality of life of LF patients, the least domain score was for mobility and the highest domain score was for Psychological Health.
简介:过去LF感染导致的大象腿在Cherthala、Alappuzha和喀拉拉邦很常见。身体残疾是指身体功能受损和难以完成日常家务。本研究旨在评估MDA后阶段丝虫病患者的生活质量。目的:评估淋巴丝虫病患者MDA后阶段的生活质量。方法:在认可的社会健康活动家(ASHA)的帮助下,在Cherthala的Thaickal和Chethy Panchayats通过健康营进行了一项横断面研究。居住在这些地区的淋巴水肿患者在征得他们的同意后,被认为有资格参加这项研究。114名慢性丝虫病患者采用经验证的问卷进行研究;淋巴丝虫病特异性生活质量问卷(LFSQQ)。领域得分表示为具有标准差的平均值。根据人口统计学特征,使用独立的t检验来比较各组的平均得分。结果:在7个领域中,流动性领域得分最低,这表明流动性是影响他们生活质量的主要问题。在心理健康领域观察到最高的领域得分,表明他们已经在心理上适应了这种情况。结论:在评估LF患者生活质量的本研究中,活动性领域得分最低,心理健康领域得分最高。
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引用次数: 0
Rabies-Monoclonal Antibody - A Perspective 狂犬病单克隆抗体研究进展
Q4 Medicine Pub Date : 2022-09-30 DOI: 10.24321/0019.5138.202285
Manasi Panda
Rabies is an acute viral zoonotic disease that affects the central nervous system (CNS) of all warm-blooded animals, including mammals. Research studies and experience from across the world have demonstrated that appropriate administration of a combination of (a) local wound treatment, (b) anti-rabies vaccination and (c) passive immunization have proved to be quite effective in preventing the occurrence of rabies. As far as passive immunization is concerned, polyclonal plasma-derived rabies immunoglobulins (RIG) pose a number of limitations with scarce supply, high cost, etc. amongst many others. On the contrary Rabies Monoclonal Antibodies (R-mAb) are much cheaper, permit longer-term storage, etc. and hence could offer a more standardized, accessible, affordable and equally efficacious and safer alternative to RIG. Accordingly, this article has tried to throw light on the transition from RIG to monoclonal antibody-based Post Exposure Prophylaxis (PEP) which has been recommended by the WHO strongly. The advantages, limitations and future scope of R-mAb have been discussed at length to give a comprehensive idea about this novel invention in the field of medicine.
狂犬病是一种急性病毒性人畜共患疾病,影响包括哺乳动物在内的所有温血动物的中枢神经系统。来自世界各地的研究和经验表明,(a)局部伤口治疗、(b)抗狂犬病疫苗接种和(c)被动免疫相结合的适当管理已被证明对预防狂犬病的发生相当有效。就被动免疫而言,多克隆血浆源性狂犬病免疫球蛋白(RIG)存在供应短缺、成本高等诸多局限性。相反,狂犬病单克隆抗体(R-mAb)更便宜,允许长期储存等,因此可以提供更标准化,可获得,负担得起,同样有效和更安全的替代RIG。因此,本文试图阐明从RIG到基于单克隆抗体的暴露后预防(PEP)的过渡,这是世卫组织强烈推荐的。本文详细讨论了R-mAb的优点、局限性和未来的应用范围,以便对这项医学领域的新发明有一个全面的认识。
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引用次数: 0
Changing Trends in the Seroprevalence of Leptospirosis in Kelambakkam: A Ten-Year Retrospective Study Kelambakkam钩端螺旋体病血清流行率的变化趋势:一项十年回顾性研究
Q4 Medicine Pub Date : 2022-06-30 DOI: 10.24321/0019.5138.202266
P. Shanmugam
Introduction: Leptospirosis is a zoonotic infection affecting humans. The main sources of infection are animal reservoir hosts and man is the accidental host in the disease transmission process. The diagnosis is usually made by microscopy, culture, molecular techniques, and serological tests like ELISA, MAT (Microscopic Agglutination Test) and MSAT (Macroscopic Slide Agglutination Test). The ELISA method to detect IgM antibodies is used as a good cost-effective testing method. An increasing titre of IgM antibody is a sign of active leptospirosis. Aims and Objectives: The study aimed to evaluate the seroprevalence of Leptospirainfection over a 10-year period in a tertiary care hospital located in Kelambakkam village in Chengalpattu district. Material and Method: The samples were tested for the presence of specific Leptospira IgM antibodies in the patient’s serum using the Panbio Leptospira IgM ELISA kit. The samples were reported as positive/ negative/ equivocal accordingly. Results: This retrospective study included a total of 2035 patients, clinically suspected of leptospirosis, over a 10-year period from 2011 to 2021. 186 patients tested positive for specific IgM antibodies by ELISA method,giving an overall prevalence rate of 9.14%. Conclusion: The seroprevalence of leptospirosis over a time period of more than 10 years is highlighted in our study. Clinical suspicion of leptospirosis should be kept in mind at all times, especially now during the COVID-19 pandemic. The Panbio Leptospira IgM ELISA test kit used in our study proves to be a very useful method for diagnostic purposes, especially in limited-resource settings.
简介:钩端螺旋体病是一种影响人类的人畜共患传染病。传染源主要为动物宿主,人是疾病传播过程中的偶然宿主。诊断通常通过显微镜、培养、分子技术和血清学测试进行,如ELISA、MAT(显微镜凝集测试)和MSAT(宏观玻片凝集测试)。ELISA法检测IgM抗体是一种经济有效的检测方法。IgM抗体滴度增加是活动性钩端螺旋体病的标志。目的和目的:本研究旨在评估Chengalpattu区Kelambakkam村一家三级护理医院10年来钩端螺旋体感染的血清流行率。材料和方法:使用Panbio钩端螺旋体IgM ELISA试剂盒检测患者血清中是否存在特异性钩端螺旋菌IgM抗体。相应地,样本报告为阳性/阴性/模棱两可。结果:这项回顾性研究在2011年至2021年的10年时间里,共纳入2035名临床怀疑为钩端螺旋体病的患者。用ELISA法检测186例患者特异性IgM抗体呈阳性,总患病率为9.14%。结论:钩端螺旋体病的血清流行率在10年以上是我们研究的重点。任何时候都应牢记钩端螺旋体病的临床怀疑,尤其是在新冠肺炎大流行期间。我们研究中使用的Panbio钩端螺旋体IgM ELISA检测试剂盒被证明是一种非常有用的诊断方法,尤其是在资源有限的情况下。
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引用次数: 0
A Case Series on GeneXpert Negative Tuberculous Mastitis and the Effect of Anti-tuberculous Treatment GeneXpert阴性结核性乳腺炎病例系列及抗结核治疗效果
Q4 Medicine Pub Date : 2022-06-30 DOI: 10.24321/0019.5138.202277
I. Ajmal
Background: Breast tuberculosis is significant due to its rare occurrence and dilemma in prospective treatment and differentiation from neoplastic lesions. Tuberculosis of the breast usually affects women from Asia, most commonly, the Indian subcontinent and Africa. Tuberculous mastitis has a wide range of clinical presentation, radiological features, and even microbiological presentation. Materials and Method: A prospective study was conducted over 6 months. 40 female patients with varied presentations correlating to tuberculous mastitis with a lump in the breast for a particular period of time were included in the study. Results: The patients’ ages varied from 20 to 45 years. After routine investigations, the patients went in for incision and drainage or incisional biopsy or both and postoperatively their histopathological reports revealed granulomatous breast disease (tuberculous mastitis) with negative GeneXpert (CB-NAAT). Patients were started on an anti-tubercular treatment regimen and showed a progressive decrease in symptomatology. Conclusion: Granulomatous breast abscess/ tuberculous breast abscess has a varied presentation and no fixed treatment regime. Anti-tuberculous drugs in such patients proved to be efficacious in symptomatic relief with prevention of recurrence/ fistula formation.
背景:乳腺结核由于其罕见的发生率以及在前瞻性治疗和与肿瘤性病变的鉴别方面的困境而具有重要意义。乳腺结核通常影响亚洲女性,最常见的是印度次大陆和非洲。结核性乳腺炎有广泛的临床表现、放射学特征,甚至微生物表现。材料和方法:一项为期6个月的前瞻性研究。该研究包括40名女性患者,她们有不同的表现,与特定时期内乳房有肿块的结核性乳腺炎相关。结果:患者年龄在20~45岁之间。在常规检查后,患者进行了切口和引流或切口活检,或两者兼有,术后他们的组织病理学报告显示肉芽肿性乳腺病(结核性乳腺炎),GeneXpert(CB-NAAT)阴性。患者开始接受抗结核治疗方案,症状逐渐减轻。结论:肉芽肿性乳腺脓肿/结核性乳腺脓肿表现多样,无固定治疗方案。在这类患者中,抗结核药物被证明在症状缓解和预防复发/瘘管形成方面是有效的。
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引用次数: 0
Parental Stress in Managing School-going Children during the COVID-19 Lockdown Period - A Pilot Study 新冠肺炎封锁期间家长在管理上学儿童方面的压力——一项试点研究
Q4 Medicine Pub Date : 2022-06-30 DOI: 10.24321/0019.5138.202273
A. Jenifer
Introduction: Parental stress has various reasons like low income, broken family, and lesser family or social support. COVID-19 and the lockdown that has been imposed have created stress among the people. This may be due to increased financial instability within the family, illness or exposure to COVID-19 itself. This study is done to assess the stress on parents in managing their school-going children. Aim: To assess the stress on parents in managing school-going children with their online classes and the factors which are concerning for the parents during the lockdown period. Materials and Method: Parents of children between the age group of 5-12 years were included in the study. These parents’ stress level was analysed based on their response to the parental stress scale. Results: The stress level is found to be on the higher side in the case of a single parent working with the mean stress level being 42.6 when compared to both parents working which had a mean stress level of 32.6. Other factors which are found to increase the stress among parents were low socioeconomic status, having children of a younger age group, and parents living in nuclear families. Conclusion: During the COVID-19 lockdown, the mental health of the parents was found to be influenced by various causes. Good family support, better work timing of parents, and a routine help in reducing stress in the family.
引言:父母的压力有多种原因,如低收入、家庭破裂、家庭或社会支持不足。新冠肺炎和已经实施的封锁在人们中造成了压力。这可能是由于家庭内部经济不稳定加剧、疾病或接触新冠肺炎本身。这项研究是为了评估家长在管理孩子上学时的压力。目的:评估家长在管理上网课上学儿童方面的压力,以及封锁期间家长关心的因素。材料和方法:将5-12岁儿童的父母纳入研究。这些父母的压力水平是根据他们对父母压力量表的反应进行分析的。结果:在单亲工作的情况下,平均压力水平为42.6,而父母双方的平均压力水平则为32.6。其他增加父母压力的因素包括社会经济地位低、孩子年龄较小以及父母生活在核心家庭。结论:新冠肺炎封锁期间,父母的心理健康受到多种原因的影响。良好的家庭支持,父母更好的工作时间,以及减轻家庭压力的常规帮助。
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引用次数: 0
Breastfeeding: Importance in Early Development of the Immune System and Long-term Health 母乳喂养:对免疫系统早期发育和长期健康的重要性
Q4 Medicine Pub Date : 2022-06-30 DOI: 10.24321/0019.5138.202280
Usha Rani
Breastfeeding supplies the baby and infant with unparalleled natural nutrients. Human breast milk also has several antimicrobial agents and may influence immune system development, as evidenced by prior research on newborn immunisation response and thymus gland development. Human milk is a dynamic supply of nutrients and bioactive ingredients and promotes the healthy growth and development of the human newborn. Infants are more susceptible to infection because their developing immune systems have a number of weaknesses. This review focuses on the direct effect of human milk on innate immunity in infants. Numerous new studies have made the multi-functionality of the bioactive components of human milk very clear. Our knowledge of the potential positive effects of human milk on infants has increased. These effects are not achievable with milk formulae. Human milk contains antimicrobial proteins and peptides that have a broader involvement in innate immune defence than previously thought. A complex combination of the anti-inflammatory and antioxidative substances that human milk supplies to the intestine results in a special environment of improved immune defence with reduced inflammation.
母乳喂养为婴儿提供了无与伦比的天然营养。人类母乳中也含有几种抗菌剂,可能会影响免疫系统的发育,此前对新生儿免疫反应和胸腺发育的研究证明了这一点。母乳是营养和生物活性成分的动态供应,促进人类新生儿的健康生长和发育。婴儿更容易受到感染,因为他们发育中的免疫系统有许多弱点。本文就母乳对婴儿先天免疫的直接影响进行综述。许多新的研究已经使人乳的生物活性成分的多功能性非常清楚。我们对母乳对婴儿潜在的积极影响的认识有所增加。这些效果是配方奶无法达到的。母乳中含有抗菌蛋白和多肽,它们在先天免疫防御中的作用比以前认为的要广泛。母乳提供给肠道的抗炎和抗氧化物质的复杂组合形成了一个特殊的环境,改善了免疫防御,减少了炎症。
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引用次数: 0
期刊
Journal of Communicable Diseases
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