Hoai Thi Yen Nguyen, Oanh-Thi Tran, Tiet Thi Mai, H. Ngo
Objective: The research was conducted to identify and assess the unmet supportive care needs of patients with cancer after a first-time hospital discharge.Material and Methods: This was a cross-sectional study using the Cancer Survivors’ Unmet Need (the CaSUN). A total of 163 cancer patients of Danang Oncology hospital were invited to the study after they were discharged from the hospital for the first-time. Data was entered and analyzed using SPSS version 20.0.Results: In total 68.7% of participants expressed at least one unmet supportive care need after a first-time hospital discharge. Specifically, 13.7% showed their unmet needs at a weak level, 31.3% had a moderate level and 23.7% a high level. However, the common unmet supportive care needs domain concerned Information and medical care (75.1%); Life perspective (70.8%); Emotions and relationships (64.2%) and Quality of life (63.6%). Conclusion: Most cancer patients indicated one or more unmet supportive care needs after first-time hospital discharge. This result will support improving healthcare service quality and raising awareness of nursing when providing care for cancer patients in the community.
{"title":"Assessment of Unmet Supportive Care Needs of Vietnamese Cancer Patients after First-Time Hospital Discharge","authors":"Hoai Thi Yen Nguyen, Oanh-Thi Tran, Tiet Thi Mai, H. Ngo","doi":"10.31584/jhsmr.2023969","DOIUrl":"https://doi.org/10.31584/jhsmr.2023969","url":null,"abstract":"Objective: The research was conducted to identify and assess the unmet supportive care needs of patients with cancer after a first-time hospital discharge.Material and Methods: This was a cross-sectional study using the Cancer Survivors’ Unmet Need (the CaSUN). A total of 163 cancer patients of Danang Oncology hospital were invited to the study after they were discharged from the hospital for the first-time. Data was entered and analyzed using SPSS version 20.0.Results: In total 68.7% of participants expressed at least one unmet supportive care need after a first-time hospital discharge. Specifically, 13.7% showed their unmet needs at a weak level, 31.3% had a moderate level and 23.7% a high level. However, the common unmet supportive care needs domain concerned Information and medical care (75.1%); Life perspective (70.8%); Emotions and relationships (64.2%) and Quality of life (63.6%). Conclusion: Most cancer patients indicated one or more unmet supportive care needs after first-time hospital discharge. This result will support improving healthcare service quality and raising awareness of nursing when providing care for cancer patients in the community.","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49181808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pornpun Sudjai, Pornpat Hengudomsub, Duangjai Vatanasin, W. Pratoomsri
Objective: This study aimed to investigate the effects of an innovative nursing approach using a smartphone application, namely “Kin Ya Kan Na” or “Let’s take Medications,” on medication adherence behaviors among patients with schizophrenia. Material and Methods: Purposive sampling was used to recruit the participants (n=84). They were randomly assigned into either an experimental (n=42) or control (n=42) group. The experimental group installed this application on their smartphones and used it for one month, along with usual nursing care while the control group received only the usual nursing care. Data were collected before and after the intervention using: 1) a demographic data form, 2) the Medication Adherence Scale in Thai (MAST), and 3) a satisfaction towards application usability’ scale. These two scales yielded Cronbach alpha coefficients of 0.94 and 0.86, respectively. Descriptive statistics and analysis of covariance (ANCOVA) were employed for data analyses. Results: The post-intervention analysis showed that the medication adherence behaviors between the two groups were significantly different (F1,81=65.225, p-value<0.001), with higher mean scores for medication adherence behaviors in theexperimental group. The application users reported that they were highly satisfied with the application (M=4.51, S.D.=0.38).Conclusion: The study found that use of this innovative nursing approach significantly improved medication adherence behaviors among these patients. Therefore, nurses and related healthcare providers could apply this approach to promote medication adherence behaviors in patients with mental illness, particularly schizophrenia.
{"title":"Effectiveness of an Innovative Nursing Approach Through a Smartphone Application in Promoting Medication Adherence Among Patients with Schizophrenia","authors":"Pornpun Sudjai, Pornpat Hengudomsub, Duangjai Vatanasin, W. Pratoomsri","doi":"10.31584/jhsmr.2023968","DOIUrl":"https://doi.org/10.31584/jhsmr.2023968","url":null,"abstract":"Objective: This study aimed to investigate the effects of an innovative nursing approach using a smartphone application, namely “Kin Ya Kan Na” or “Let’s take Medications,” on medication adherence behaviors among patients with schizophrenia. Material and Methods: Purposive sampling was used to recruit the participants (n=84). They were randomly assigned into either an experimental (n=42) or control (n=42) group. The experimental group installed this application on their smartphones and used it for one month, along with usual nursing care while the control group received only the usual nursing care. Data were collected before and after the intervention using: 1) a demographic data form, 2) the Medication Adherence Scale in Thai (MAST), and 3) a satisfaction towards application usability’ scale. These two scales yielded Cronbach alpha coefficients of 0.94 and 0.86, respectively. Descriptive statistics and analysis of covariance (ANCOVA) were employed for data analyses. Results: The post-intervention analysis showed that the medication adherence behaviors between the two groups were significantly different (F1,81=65.225, p-value<0.001), with higher mean scores for medication adherence behaviors in theexperimental group. The application users reported that they were highly satisfied with the application (M=4.51, S.D.=0.38).Conclusion: The study found that use of this innovative nursing approach significantly improved medication adherence behaviors among these patients. Therefore, nurses and related healthcare providers could apply this approach to promote medication adherence behaviors in patients with mental illness, particularly schizophrenia. ","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45166550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: One of the main problems, for patients under a mechanical ventilator, is their inability to verbally communicate. This condition can cause psychological problems; such as anxiety. Additionally, as anxiety must be treated immediately to prevent adverse effects for the patient, one effective strategy is augmentative alternative communication (AAC). Hence, the purpose of this study was to determine the effect of AAC on anxiety in patients, who are on mechanical ventilators. Material and Methods: This study was pre-experimental, consisting of a one-group pre-test post-test design: conducted using consecutive sampling. The AAC was conducted using a book while the anxiety instrument was the face anxiety scale (FAS). Conducting AAC and measurements of anxiety were carried out by a research assistant. Anxiety was based on anxiety scores and physiological parameters via. Bivariate data analysis using Wilcoxon Sign Rank Test. Results: The patient’s level of anxiety before and after AAC had difference scores of 2, wherein the pre-test was moderate anxiety and the post-test after being given AAC was no anxiety. The physiological parameters, before and after AAC, did not change clinically, because they were still within normal limits. Wilcoxon Sign Rank test results (p-value=0.001) with Cramer’s v value (0.21) Conclusion: AAC has a positive effect having statistically and clinically significant changes in anxiety and has a medium effect size on anxiety level.
{"title":"The Effect of Augmentative Alternative Communication on Anxiety in Patients under Mechanical Ventilators in the Intensive Care Unit: Pilot Study","authors":"Ni Luh Sekar Astuti, Sri Setiyarini, I. Rahmat","doi":"10.31584/jhsmr.2023967","DOIUrl":"https://doi.org/10.31584/jhsmr.2023967","url":null,"abstract":"Objective: One of the main problems, for patients under a mechanical ventilator, is their inability to verbally communicate. This condition can cause psychological problems; such as anxiety. Additionally, as anxiety must be treated immediately to prevent adverse effects for the patient, one effective strategy is augmentative alternative communication (AAC). Hence, the purpose of this study was to determine the effect of AAC on anxiety in patients, who are on mechanical ventilators. Material and Methods: This study was pre-experimental, consisting of a one-group pre-test post-test design: conducted using consecutive sampling. The AAC was conducted using a book while the anxiety instrument was the face anxiety scale (FAS). Conducting AAC and measurements of anxiety were carried out by a research assistant. Anxiety was based on anxiety scores and physiological parameters via. Bivariate data analysis using Wilcoxon Sign Rank Test. Results: The patient’s level of anxiety before and after AAC had difference scores of 2, wherein the pre-test was moderate anxiety and the post-test after being given AAC was no anxiety. The physiological parameters, before and after AAC, did not change clinically, because they were still within normal limits. Wilcoxon Sign Rank test results (p-value=0.001) with Cramer’s v value (0.21) Conclusion: AAC has a positive effect having statistically and clinically significant changes in anxiety and has a medium effect size on anxiety level.","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41375588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. R. Abidin, A. Meliala, Sri Lestari Sulistyo Rini
Objective: This study aimed to investigate the combined effects of caffeine and Alpha Lipoic Acid (ALA) on oxidative stress, due to chronic hyperglycemia, in a model of diabetic rats induced with streptozotocin (STZ) (in silico and in vivo approaches). Material and Methods: This In silico study investigated the interaction between caffeine and ALA against insulin receptors and enzymes of Glutathione Peroksidase-1 (GPx-1), with molecular docking. Male, Wistar rats were included using a quasi-experimental research design, with post-test only and a control group (in vivo). This study measured the end result of a 6-week-induction on body weight, fasting blood glucose, Malondialdehyde (MDA) and GPx-1 enzyme from 25 rats. Results: Molecular docking found the interactions of caffeine and GPx-1 consisting of an energy bond of -5,06 kcal/mol, hydrogen and hydrophobic bond. Additionally, it showed the interaction of ALA and GPx-1 containing an energy bond of -5.16 kcal/mol, hydrogen bonding and hydrophobicity. However, there were no significant difference in body weight, fasting blood glucose, MDA and GPx-1 levels of the ALA-caffeinated diabetic rats compared to diabetic rats.Conclusion: Caffeine and ALA have the potential to activate GPx-1 enzymes (in silico study). However, the use of a caffeine and ALA combination resulted in no significant difference in fasting blood glucose and oxidative stress conditions when compared to diabetic rats without additional induction (in vivo study).
{"title":"Effects of Caffeine mixed with Alpha Lipoic Acid in Preventing Streptozotocin-induced Diabetes in Rats: In Silico and In vivo Study","authors":"K. R. Abidin, A. Meliala, Sri Lestari Sulistyo Rini","doi":"10.31584/jhsmr.2023965","DOIUrl":"https://doi.org/10.31584/jhsmr.2023965","url":null,"abstract":"Objective: This study aimed to investigate the combined effects of caffeine and Alpha Lipoic Acid (ALA) on oxidative stress, due to chronic hyperglycemia, in a model of diabetic rats induced with streptozotocin (STZ) (in silico and in vivo approaches). Material and Methods: This In silico study investigated the interaction between caffeine and ALA against insulin receptors and enzymes of Glutathione Peroksidase-1 (GPx-1), with molecular docking. Male, Wistar rats were included using a quasi-experimental research design, with post-test only and a control group (in vivo). This study measured the end result of a 6-week-induction on body weight, fasting blood glucose, Malondialdehyde (MDA) and GPx-1 enzyme from 25 rats. Results: Molecular docking found the interactions of caffeine and GPx-1 consisting of an energy bond of -5,06 kcal/mol, hydrogen and hydrophobic bond. Additionally, it showed the interaction of ALA and GPx-1 containing an energy bond of -5.16 kcal/mol, hydrogen bonding and hydrophobicity. However, there were no significant difference in body weight, fasting blood glucose, MDA and GPx-1 levels of the ALA-caffeinated diabetic rats compared to diabetic rats.Conclusion: Caffeine and ALA have the potential to activate GPx-1 enzymes (in silico study). However, the use of a caffeine and ALA combination resulted in no significant difference in fasting blood glucose and oxidative stress conditions when compared to diabetic rats without additional induction (in vivo study). ","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43197270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ershad Ali, F. Hossain, A. Khan, Mohammad Arifur Rahman, E. Rahman, S. Islam
Objective: To observe the effectiveness of Pilate’s exercise, with postural advice to reduce low back pain for lower limb amputee patients. Material and Methods: An assessor-blind, randomised control trial design has been used wherein sixty-two patients were divided into two groups by simple random allocation. The experimental group received the Pilates’ Training Program with postural advice, and the control group received usual care at the prosthetic department. There were thrity-one participants in both groups that completed the study. Both groups attended a 15-minute specialized, supervised session; 5 days a week, for 4 weeks. Outcomes were measured in terms of pain by a numeric pain rating scale and specific function & disability of the lumbo-pelvic region by the Roland-Morris Low Back Pain and Disability Questionnaire. Descriptive (median and inter quartile range, IQR) and inferential statistics (Pearson Chi-square test, Mann-Whitney U test and Wilcoxon Signed Rank Test) were performed to analyse the data through the Statistical Package for Social Sciences (SPSS), Windows version 25 (IBM, Armonk, NY, USA). Results: Average age of participants was 33 (29.75 to 47.50) years; whereas, the average duration of amputation in the experimental group was 11 (7 to 13) months compared to 8 (6 to 11) months in the control group. Both groups showed significant improvement in terms of pain intensity and functional ability in intergroup analysis (p-value<0.05); additionally, in intra-group analysis participants that received Pilate’s exercise with postural advice had better outcomes than participants who received only postural advice (p-value<0.05). Conclusions: It was concluded that Pilate’s exercise with postural advice is effective in the rehabilitation of patients with lower limb amputee-induced low back pain. Additionally, Pilate’s exercises with postural advice also led to better improvement in mechanical correction of the lumbo pelvic region.
{"title":"Efficacy of Pilate’s Exercise with Postural Advice in the Management of Low Back Pain for Lower Limb Amputee Patients: A Randomised Control Trial","authors":"Ershad Ali, F. Hossain, A. Khan, Mohammad Arifur Rahman, E. Rahman, S. Islam","doi":"10.31584/jhsmr.2023966","DOIUrl":"https://doi.org/10.31584/jhsmr.2023966","url":null,"abstract":"Objective: To observe the effectiveness of Pilate’s exercise, with postural advice to reduce low back pain for lower limb amputee patients. Material and Methods: An assessor-blind, randomised control trial design has been used wherein sixty-two patients were divided into two groups by simple random allocation. The experimental group received the Pilates’ Training Program with postural advice, and the control group received usual care at the prosthetic department. There were thrity-one participants in both groups that completed the study. Both groups attended a 15-minute specialized, supervised session; 5 days a week, for 4 weeks. Outcomes were measured in terms of pain by a numeric pain rating scale and specific function & disability of the lumbo-pelvic region by the Roland-Morris Low Back Pain and Disability Questionnaire. Descriptive (median and inter quartile range, IQR) and inferential statistics (Pearson Chi-square test, Mann-Whitney U test and Wilcoxon Signed Rank Test) were performed to analyse the data through the Statistical Package for Social Sciences (SPSS), Windows version 25 (IBM, Armonk, NY, USA). Results: Average age of participants was 33 (29.75 to 47.50) years; whereas, the average duration of amputation in the experimental group was 11 (7 to 13) months compared to 8 (6 to 11) months in the control group. Both groups showed significant improvement in terms of pain intensity and functional ability in intergroup analysis (p-value<0.05); additionally, in intra-group analysis participants that received Pilate’s exercise with postural advice had better outcomes than participants who received only postural advice (p-value<0.05). Conclusions: It was concluded that Pilate’s exercise with postural advice is effective in the rehabilitation of patients with lower limb amputee-induced low back pain. Additionally, Pilate’s exercises with postural advice also led to better improvement in mechanical correction of the lumbo pelvic region.","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44505333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. D. Tran, N. Nguyện, H. Nguyen, Hien Thi Thu Nguyen, T. T. Nguyen, Phong Hong Nguyen, Hung Gia Tran
Objective: Klebsiella pneumoniae (K. pneumoniae) is one of the most prevalent human pathogens. Carbapenemaseproducing klebsiella pneumoniae (CPKP) has recently developed significant antibiotic resistance, not just to carbapenem antibiotics but also to the majority of other currently available antibiotics. Prior to this point, there have been few international studies or publications on the situation of CPKP in Vietnam. Hence, this study was conducted to determine the antibiotic resistance of K. pneumoniae and CPKP strains in Can Tho, Vietnam. Material and Methods: In total, 345 K. pneumoniae strains were isolated. Antibiotic susceptibility was assessed via an automated microbiological system. A modified carbapenem inactivation assay was applied to identify CPKP strains, followed by the use of the MASTDISCS combi Carba plus disc system to classify certain carbapenemases. Results: Of the 345 K. pneumoniae strains, 110 represented an isolation rate of 31.9%. There was a significant correlation (p-value<0.05) between the specimen type, hospital unit and CPKP ratio. All the examined CPKP strains exhibited complete resistance to penicillin and cefazolin. The CPKP strains were also significantly more resistant to PTZ, cefepime, ciprofloxacin and imipenem than the non-CPKP strains (p-value<0.05). Amikacin, gentamicin and TMP/SMX have been shown to be effective in treating patients infected with CPKP strains. Conclusion: CPKP accounts for 31.9% of all K. pneumoniae infections. K. pneumoniae and CPKP exhibited the highest levels of resistance to ampicillin, cefazoline, ciprofloxacin, ceftriaxone and ceftazidime. Amikacin, gentamicin and TMP/ SMX were the least resistant antibiotics tested.
{"title":"The Situation of Antibiotic Resistance in Klebsiella Pneumoniae and Carbapenemase-Producing Klebsiella Pneumoniae in Vietnam: A Cross-Sectional Study","authors":"H. D. Tran, N. Nguyện, H. Nguyen, Hien Thi Thu Nguyen, T. T. Nguyen, Phong Hong Nguyen, Hung Gia Tran","doi":"10.31584/jhsmr.2023964","DOIUrl":"https://doi.org/10.31584/jhsmr.2023964","url":null,"abstract":"Objective: Klebsiella pneumoniae (K. pneumoniae) is one of the most prevalent human pathogens. Carbapenemaseproducing klebsiella pneumoniae (CPKP) has recently developed significant antibiotic resistance, not just to carbapenem antibiotics but also to the majority of other currently available antibiotics. Prior to this point, there have been few international studies or publications on the situation of CPKP in Vietnam. Hence, this study was conducted to determine the antibiotic resistance of K. pneumoniae and CPKP strains in Can Tho, Vietnam. Material and Methods: In total, 345 K. pneumoniae strains were isolated. Antibiotic susceptibility was assessed via an automated microbiological system. A modified carbapenem inactivation assay was applied to identify CPKP strains, followed by the use of the MASTDISCS combi Carba plus disc system to classify certain carbapenemases. Results: Of the 345 K. pneumoniae strains, 110 represented an isolation rate of 31.9%. There was a significant correlation (p-value<0.05) between the specimen type, hospital unit and CPKP ratio. All the examined CPKP strains exhibited complete resistance to penicillin and cefazolin. The CPKP strains were also significantly more resistant to PTZ, cefepime, ciprofloxacin and imipenem than the non-CPKP strains (p-value<0.05). Amikacin, gentamicin and TMP/SMX have been shown to be effective in treating patients infected with CPKP strains. Conclusion: CPKP accounts for 31.9% of all K. pneumoniae infections. K. pneumoniae and CPKP exhibited the highest levels of resistance to ampicillin, cefazoline, ciprofloxacin, ceftriaxone and ceftazidime. Amikacin, gentamicin and TMP/ SMX were the least resistant antibiotics tested. ","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48464300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shaikh Mohammed Aslam S, Mohammed Suhail K, A. Kulkarni
Objective: To evaluate the clinical features and laboratory profile of elderly patients with Coronavirus Disease-19 (COVID-19) at a tertiary care centre in South India. Material and Methods: A hospital-based retrospective study was conducted in 1,744 elderly patients by collecting the clinical and laboratory data from COVID-19 confirmed patients from May 2020 to June 2021 in a tertiary care hospital in Bangalore, India. The clinical features, comorbidities, serum biochemical parameters and inflammatory markers were recorded and collated with disease outcomes. The clinical presentation, inflammatory markers were studied and compared between survivors and non-survivors. P-value less than 0.05 set as statistical significance. Results: The mean age of the patients was 69.7±7.4 years and the male: female ratio was 1.65:1. The most common comorbidity reported in elderly patients with COVID-19 was type 2 diabetes mellitus (46.8%), followed by hypertension (35.7%), chronic kidney disease (10.7%), and ischemic heart disease (6.47%). 41.9% of the patients did not have any co-morbidities. Out of the 1,744 elderly patients, 164 (9.4%) died and mortality was highest in the COVID-19 patients with severe disease (103 patients, 62.8%). Inflammatory markers of neutrophil/lymphocyte ratio (N/L ratio), lactate dehydrogenase (LDH), ferritin, C-reactive protein (CRP), D-Dimers and interleukin-6 were significantly elevated among the patients who did not survive. Conclusion: Mortality was highest in elderly COVID-19 patients with severe disease and most of the patients who died had one or more comorbidities. Neutrophilia, lymphopenia, eosinopenia along with elevated N/L ratio, LDH, ferritin, D-dimer, IL-6 and CRP were significantly associated with adverse disease outcomes.
{"title":"Clinical and Epidemiological Characteristics of Elderly Patients with Coronavirus Disease-19 at a Tertiary Care Center in South India","authors":"Shaikh Mohammed Aslam S, Mohammed Suhail K, A. Kulkarni","doi":"10.31584/jhsmr.2023963","DOIUrl":"https://doi.org/10.31584/jhsmr.2023963","url":null,"abstract":"Objective: To evaluate the clinical features and laboratory profile of elderly patients with Coronavirus Disease-19 (COVID-19) at a tertiary care centre in South India. Material and Methods: A hospital-based retrospective study was conducted in 1,744 elderly patients by collecting the clinical and laboratory data from COVID-19 confirmed patients from May 2020 to June 2021 in a tertiary care hospital in Bangalore, India. The clinical features, comorbidities, serum biochemical parameters and inflammatory markers were recorded and collated with disease outcomes. The clinical presentation, inflammatory markers were studied and compared between survivors and non-survivors. P-value less than 0.05 set as statistical significance. Results: The mean age of the patients was 69.7±7.4 years and the male: female ratio was 1.65:1. The most common comorbidity reported in elderly patients with COVID-19 was type 2 diabetes mellitus (46.8%), followed by hypertension (35.7%), chronic kidney disease (10.7%), and ischemic heart disease (6.47%). 41.9% of the patients did not have any co-morbidities. Out of the 1,744 elderly patients, 164 (9.4%) died and mortality was highest in the COVID-19 patients with severe disease (103 patients, 62.8%). Inflammatory markers of neutrophil/lymphocyte ratio (N/L ratio), lactate dehydrogenase (LDH), ferritin, C-reactive protein (CRP), D-Dimers and interleukin-6 were significantly elevated among the patients who did not survive. Conclusion: Mortality was highest in elderly COVID-19 patients with severe disease and most of the patients who died had one or more comorbidities. Neutrophilia, lymphopenia, eosinopenia along with elevated N/L ratio, LDH, ferritin, D-dimer, IL-6 and CRP were significantly associated with adverse disease outcomes.","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41408225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natthaka Sathaporn, B. Khwannimit, T. Wisaratapong, S. Wongpraphairot
Herein, is a reported case of an 86-year-old woman, admitted due to complete atrioventricular block. During admission, she was diagnosed and treated with ritonavir-boosted nirmatrelvir (Paxlovid) for the coronavirus disease 2019 (COVID-19). Four days after initiating the treatment for COVID-19, an oral dose of 20 mg manidipine was administrated. Five hours later, the patient developed hypotension that eventually progressed to refractory shock requiring a maximum dose of 1.82 µg/kg/min of norepinephrine equivalent. Shock reversal dramatically improved within 17 hours after the cause of shock was diagnosed, and her having receiving specific treatment via intravenous calcium administration and high-dose insulin euglycemia therapy (HIE).
{"title":"A Rare Cause of Refractory Vasodilatory Shock Due to Calcium Channel Blocker Toxicity from Drug-Drug Interaction Between Ritonavir-Boosted Nirmatrelvir (Paxlovid) And Manidipine","authors":"Natthaka Sathaporn, B. Khwannimit, T. Wisaratapong, S. Wongpraphairot","doi":"10.31584/jhsmr.2023962","DOIUrl":"https://doi.org/10.31584/jhsmr.2023962","url":null,"abstract":"Herein, is a reported case of an 86-year-old woman, admitted due to complete atrioventricular block. During admission, she was diagnosed and treated with ritonavir-boosted nirmatrelvir (Paxlovid) for the coronavirus disease 2019 (COVID-19). Four days after initiating the treatment for COVID-19, an oral dose of 20 mg manidipine was administrated. Five hours later, the patient developed hypotension that eventually progressed to refractory shock requiring a maximum dose of 1.82 µg/kg/min of norepinephrine equivalent. Shock reversal dramatically improved within 17 hours after the cause of shock was diagnosed, and her having receiving specific treatment via intravenous calcium administration and high-dose insulin euglycemia therapy (HIE).","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45886879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Occupational accidents and diseases in Indonesia are still a scourge because they not only cause minor and serious accidents, but often result in fatalities. The same occupational accidents and diseases’ would seem to be happening in the coal mining business sector. According to the Badan Penyelenggara Jaminan Sosial Indonesia, 234,370 cases of work accidents and work-related illnesses occurred in 2021, of which the mining sector contributed 6,565 cases. Collaboration between companies, workers and local governments in the management of work accident reporting needs special attention so that similar incidents do not occur in the future.Material and Methods: This literature review supports the researchers hypothesis or belief in disclosing that there is an increasingly open space for collaboration between companies, workers and local governments in accident reporting management to reduce accidents. The literature review search term used is work accident reporting sourced from Google Scholar, National Library of Indonesia, PubMed, and other sources in the 2017-2022 period.Results:This literature review found a number of facts that companies have an obligation as stipulated in the Regulation of the Minister of Manpower of the Republic of Indonesia No. 03 of 1998 concerning Accident Reporting and Investigation Procedures to report every work accident and work-related illness that occurs both periodically and specifically to the competent authority. Likewise, workers have the responsibility to report any accidents and potential hazards found in the workplace to the occupational safety and health officer. The Regional Government is no exception, which is a regulator and at the same time supervises companies in carrying out their business activities.Conclusion: To reduce workplace accidents requires diligent and constructive cooperation between the business managers, the workers, and the government regulators to support a zero-accident work environment.
{"title":"Collaboration Tripartite Elements Accident Reporting and Potential Hazards Management Coal Mining, Indonesia: Systematic Review","authors":"Muhammad Sultan","doi":"10.31584/jhsmr.2023961","DOIUrl":"https://doi.org/10.31584/jhsmr.2023961","url":null,"abstract":"Objective: Occupational accidents and diseases in Indonesia are still a scourge because they not only cause minor and serious accidents, but often result in fatalities. The same occupational accidents and diseases’ would seem to be happening in the coal mining business sector. According to the Badan Penyelenggara Jaminan Sosial Indonesia, 234,370 cases of work accidents and work-related illnesses occurred in 2021, of which the mining sector contributed 6,565 cases. Collaboration between companies, workers and local governments in the management of work accident reporting needs special attention so that similar incidents do not occur in the future.Material and Methods: This literature review supports the researchers hypothesis or belief in disclosing that there is an increasingly open space for collaboration between companies, workers and local governments in accident reporting management to reduce accidents. The literature review search term used is work accident reporting sourced from Google Scholar, National Library of Indonesia, PubMed, and other sources in the 2017-2022 period.Results:This literature review found a number of facts that companies have an obligation as stipulated in the Regulation of the Minister of Manpower of the Republic of Indonesia No. 03 of 1998 concerning Accident Reporting and Investigation Procedures to report every work accident and work-related illness that occurs both periodically and specifically to the competent authority. Likewise, workers have the responsibility to report any accidents and potential hazards found in the workplace to the occupational safety and health officer. The Regional Government is no exception, which is a regulator and at the same time supervises companies in carrying out their business activities.Conclusion: To reduce workplace accidents requires diligent and constructive cooperation between the business managers, the workers, and the government regulators to support a zero-accident work environment. ","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42919103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To determine the incidence of carbapenem-resistant Enterobacteriaceae (CRE) infection in patients with CRE colonization and compare the treatment outcomes between febrile patients with non-septic presentation who received empirical treatment with meropenem and those who did not. Material and Methods: The medical records of febrile patients with CRE colonization aged <15 years who were hospitalized at Songklanagarind Hospital between January 2018 and December 2020 were reviewed. Results: Among the 61 patients with CRE colonization, CRE infection was identified during eight febrile episodes in six patients (9.8%). Hematologic malignancies, solid tumors, and other diseases were diagnosed in 21 (34.4%), 25 (41.0%), and 15 (24.6%) patients, respectively. The median (interquartile range [IQR]) duration from CRE colonization to the first episode of fever was 22 (1.8–60.8) days. Among the 82 febrile episodes without initial sepsis or central nervous system infection, 19 and 63 episodes, respectively, were initially treated with meropenem and non-carbapenems. Treatment outcomes—including the proportion of patients needing step-up antibiotics (21.1% vs. 36.5%), development of sepsis (5.3% vs. 15.9%), and death within 30 days (6.6% vs. 9.8%) - were not significantly different between the two groups.Patients who developed sepsis had significantly higher resistance to empirical antibiotics (75% vs. 26.3%) as well as a significantly higher incidence of severe neutropenia lasting more than one week (85.7% vs. 21.9%) than those without sepsis.Conclusion: Patients with CRE colonization who exhibit fever without clinical sepsis and have an absolute neutrophil count >100 cells/mm3 can be empirically treated with non-carbapenems.
{"title":"Carbapenem-Resistant Enterobacteriaceae Infection in Immunocompromised Children with CRE Colonization: Incidence and Outcomes in an Antibiotic-Limited Setting","authors":"Chadakorn Rattanaburee, Puttichart Khantee, Kamolwish Laoprasopwattana","doi":"10.31584/jhsmr.2023960","DOIUrl":"https://doi.org/10.31584/jhsmr.2023960","url":null,"abstract":"Objective: To determine the incidence of carbapenem-resistant Enterobacteriaceae (CRE) infection in patients with CRE colonization and compare the treatment outcomes between febrile patients with non-septic presentation who received empirical treatment with meropenem and those who did not. Material and Methods: The medical records of febrile patients with CRE colonization aged <15 years who were hospitalized at Songklanagarind Hospital between January 2018 and December 2020 were reviewed. Results: Among the 61 patients with CRE colonization, CRE infection was identified during eight febrile episodes in six patients (9.8%). Hematologic malignancies, solid tumors, and other diseases were diagnosed in 21 (34.4%), 25 (41.0%), and 15 (24.6%) patients, respectively. The median (interquartile range [IQR]) duration from CRE colonization to the first episode of fever was 22 (1.8–60.8) days. Among the 82 febrile episodes without initial sepsis or central nervous system infection, 19 and 63 episodes, respectively, were initially treated with meropenem and non-carbapenems. Treatment outcomes—including the proportion of patients needing step-up antibiotics (21.1% vs. 36.5%), development of sepsis (5.3% vs. 15.9%), and death within 30 days (6.6% vs. 9.8%) - were not significantly different between the two groups.Patients who developed sepsis had significantly higher resistance to empirical antibiotics (75% vs. 26.3%) as well as a significantly higher incidence of severe neutropenia lasting more than one week (85.7% vs. 21.9%) than those without sepsis.Conclusion: Patients with CRE colonization who exhibit fever without clinical sepsis and have an absolute neutrophil count >100 cells/mm3 can be empirically treated with non-carbapenems.","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43813422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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