W. Wichaidit, S. Assanangkornchai, Jirawan Jayuphan
Objective: The objectives of this study were to describe: 1) cannabis use behaviors; 2) self-reported cannabis-related harms and harmful behaviors among adults in Thailand, stratified by sex (assigned at birth) and age groups.Material and Methods: A nationally-representative survey among adults in Thailand in May 2023 was conducted. Data using descriptive statistics with sampling weight adjustment was analyzed.Results: Among the study participants (n=2,191 participants), approximately 15% of the participants were current cannabis users (estimated number: 7.5 million people aged 20 or over nationwide). Former and current users reported recreation or other non-medical purposes as the primary purposes of use (93% combined). Ingestion was the most common method of cannabis use. Male participants were more likely than female participants in all age groups to report using smoked cannabis. The most common harmful was riding a motorcycle after having used cannabis, although virtually no participants reported road accidents after same-day cannabis use.Conclusion: This study's data provided basic information for relevant stakeholders. However, the lack of detailed information, the potential influence of social desirability, and the limited temporal generalizability should be considered in the interpretation of this study’s findings.
{"title":"Cannabis Use Behaviors and Related Harms among Adults in Thailand by Sex Assigned at Birth and Age Groups","authors":"W. Wichaidit, S. Assanangkornchai, Jirawan Jayuphan","doi":"10.31584/jhsmr.20241052","DOIUrl":"https://doi.org/10.31584/jhsmr.20241052","url":null,"abstract":"Objective: The objectives of this study were to describe: 1) cannabis use behaviors; 2) self-reported cannabis-related harms and harmful behaviors among adults in Thailand, stratified by sex (assigned at birth) and age groups.Material and Methods: A nationally-representative survey among adults in Thailand in May 2023 was conducted. Data using descriptive statistics with sampling weight adjustment was analyzed.Results: Among the study participants (n=2,191 participants), approximately 15% of the participants were current cannabis users (estimated number: 7.5 million people aged 20 or over nationwide). Former and current users reported recreation or other non-medical purposes as the primary purposes of use (93% combined). Ingestion was the most common method of cannabis use. Male participants were more likely than female participants in all age groups to report using smoked cannabis. The most common harmful was riding a motorcycle after having used cannabis, although virtually no participants reported road accidents after same-day cannabis use.Conclusion: This study's data provided basic information for relevant stakeholders. However, the lack of detailed information, the potential influence of social desirability, and the limited temporal generalizability should be considered in the interpretation of this study’s findings.","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140744543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BM Shareef, Vinod Joshi, B. Angel, Annette Angel, Bhawna Sharma, Neha Singh, Shilpa Barthwal, Poorna Khaneja, N. Peer, A. Khan, Ramesh Joshi, Kiran Yadav, Komal Tomar, Satendra Pal Singh
Objective: The severe acute type of respiratory distress caused by Coronavirus disease 2019 (COVID-19) was responsible for the global pandemic of 2019. While most of the focus of vaccine/drug molecules is on the receptor, there are certain enzymes that also need to be checked. Cell surface proteases are one of these. Activation of the virus spike protein becomes more complicated when many host proteases are involved. As many Variants of Concerns have been reported in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), this study aimed to understand the proteolytic function of Furin in each, and its involvement in virus-host interaction. Material and Methods: Spike Protein sequence alignment, furin cleavage site prediction of variants: Wuhan, Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2) and Omicron (B.1.1.529), and protein-protein docking studies have been undertaken using appropriate bioinformatics tools. Results: It was observed that when compared to previous variations, the November 2021, outbreak of Omicron variant showed 50 amino acid substitutions in the Spike protein. Thus, in addition to the Angiotensin Converting Enzyme 2 (ACE-2) receptor, the role of virus binding sites to act as “Addition Receptors” for viral entry has been reported here. Conclusion: It was observed that substitution of basic amino acids in the Omicron variant may be responsible for the recognition of furin cleavage sites and the presence of furin cleavage site in the receptor binding domain (RBD) region will thus enhance viral transmission. If these sites are utilized in formulation of new drugs/vaccine molecules to target the furin hydrolyse sites, we may be able to add to the existing course of COVID-19 treatment.
{"title":"Role of Furin Activation Sites as Receptors for Invasion of Severe Acute Respiratory Syndrome Coronavirus-2 Into Human Cells","authors":"BM Shareef, Vinod Joshi, B. Angel, Annette Angel, Bhawna Sharma, Neha Singh, Shilpa Barthwal, Poorna Khaneja, N. Peer, A. Khan, Ramesh Joshi, Kiran Yadav, Komal Tomar, Satendra Pal Singh","doi":"10.31584/jhsmr.20241051","DOIUrl":"https://doi.org/10.31584/jhsmr.20241051","url":null,"abstract":"Objective: The severe acute type of respiratory distress caused by Coronavirus disease 2019 (COVID-19) was responsible for the global pandemic of 2019. While most of the focus of vaccine/drug molecules is on the receptor, there are certain enzymes that also need to be checked. Cell surface proteases are one of these. Activation of the virus spike protein becomes more complicated when many host proteases are involved. As many Variants of Concerns have been reported in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), this study aimed to understand the proteolytic function of Furin in each, and its involvement in virus-host interaction. Material and Methods: Spike Protein sequence alignment, furin cleavage site prediction of variants: Wuhan, Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2) and Omicron (B.1.1.529), and protein-protein docking studies have been undertaken using appropriate bioinformatics tools. Results: It was observed that when compared to previous variations, the November 2021, outbreak of Omicron variant showed 50 amino acid substitutions in the Spike protein. Thus, in addition to the Angiotensin Converting Enzyme 2 (ACE-2) receptor, the role of virus binding sites to act as “Addition Receptors” for viral entry has been reported here. Conclusion: It was observed that substitution of basic amino acids in the Omicron variant may be responsible for the recognition of furin cleavage sites and the presence of furin cleavage site in the receptor binding domain (RBD) region will thus enhance viral transmission. If these sites are utilized in formulation of new drugs/vaccine molecules to target the furin hydrolyse sites, we may be able to add to the existing course of COVID-19 treatment.","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140752766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shamita Mariam Idiculla, G. SANKAR U, Monisha Ravikumar, Redkar Simran Sandeep
Objective: To investigate the effect of cognitive orientation to daily occupational performance (CO-OP) programme on playfulness in children with attention deficit hyperactivity disorder.Material and Methods: Seventy Attention deficit hyperactivity disorder participants (N=70), aged between 6-8 years were recruited from a local community-based setting. The children were divided into an experimental (n=35) and a control group (n=35). The experimental group participants received CO-OP and the control group participants received the conventional occupational therapy programme; for 12 weeks. The test on playfulness was used to measure playfulness in children.Results: There were statistically significant differences between pretest and post-test scores of the test of playfulness (TOP) in the experimental group (p-value≤0.05) components of: Extent, Intensity and Skillfulness, and there were statistically significant differences between pretest and post-test group of TOP in the control group (p-value≤0.05) in Intensity and Skillfulness. There was no statistically significant difference in pretest and post-test scores of TOP in the component of Extent. Further analysis revealed that clinically there was significant differences in the post-test scores of TOP between the control and experimental group components of Extent, Intensity and Skillfulness.Conclusion: CO-OP was effective in improving playfulness in children with attention deficit hyperactivity disorder.
{"title":"Effect of Cognitive Orientation to Daily Occupational Performance (CO-OP) Programme on Playfulness in Children with Attention Deficit Hyperactivity Disorder","authors":"Shamita Mariam Idiculla, G. SANKAR U, Monisha Ravikumar, Redkar Simran Sandeep","doi":"10.31584/jhsmr.20241050","DOIUrl":"https://doi.org/10.31584/jhsmr.20241050","url":null,"abstract":"Objective: To investigate the effect of cognitive orientation to daily occupational performance (CO-OP) programme on playfulness in children with attention deficit hyperactivity disorder.Material and Methods: Seventy Attention deficit hyperactivity disorder participants (N=70), aged between 6-8 years were recruited from a local community-based setting. The children were divided into an experimental (n=35) and a control group (n=35). The experimental group participants received CO-OP and the control group participants received the conventional occupational therapy programme; for 12 weeks. The test on playfulness was used to measure playfulness in children.Results: There were statistically significant differences between pretest and post-test scores of the test of playfulness (TOP) in the experimental group (p-value≤0.05) components of: Extent, Intensity and Skillfulness, and there were statistically significant differences between pretest and post-test group of TOP in the control group (p-value≤0.05) in Intensity and Skillfulness. There was no statistically significant difference in pretest and post-test scores of TOP in the component of Extent. Further analysis revealed that clinically there was significant differences in the post-test scores of TOP between the control and experimental group components of Extent, Intensity and Skillfulness.Conclusion: CO-OP was effective in improving playfulness in children with attention deficit hyperactivity disorder.","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140369138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To investigate the associated factors that affect time to relapse in patients with schizophrenia at St. Amanuel Mental Specialized Hospital, with recurrent events model.Material and Methods: A hospital-based retrospective review of the medical records of 332 patient with schizophrenia, covering a two-year period, were examined. Parametric frailty models were used to determine the correlation between discharge times and relapse, and to identify risk factors using R-software. Results: The distribution number of relapses was 162, and the median survival time of patients with schizophrenia was 665 days. The unobserved heterogeneity in patients and correlation between relapses, as estimated by the Weibull-gamma frailty model, was p-value≤0.001 and Kendall’s Tau (Γ)=0.498. This indicated that there was heterogeneity among participants and a correlation between relapses. The final model showed that the effect of psychiatric comorbidity (hazard ratio (HR)=6.522, p-value≤0.001), employment status (HR=5.334, p-value=0.001), history of suicide attempt (HR=2.167, p-value=0.003) and history of traditional treatment (HR=1.973262, p-value=0.021) had a significant effect on the hazard time to relapse. Onset Age of schizophrenia and drug adherence were not predictive. Subsequent relapses are likely dependent on both the first and previous relapses.Conclusion: Comorbidity, employment status, history of suicide attempt and history of traditional treatment are imperative risk factors influencing the hazard of time to relapse, which increases the risk of relapse.
目的采用复发事件模型，研究影响圣阿曼努尔精神病专科医院精神分裂症患者复发时间的相关因素：以医院为基础，对 332 名精神分裂症患者为期两年的病历进行回顾性研究。使用参数虚弱模型确定出院时间与复发之间的相关性，并使用 R 软件识别风险因素。研究结果复发次数分布为 162 次，精神分裂症患者的中位生存时间为 665 天。根据 Weibull-gamma 脆弱性模型估计，患者的未观察异质性和复发之间的相关性的 p 值≤0.001，Kendall's Tau（Γ）=0.498。这表明参与者之间存在异质性以及复发之间的相关性。最终模型显示，精神病合并症（危险比（HR）=6.522，P值≤0.001）、就业状况（HR=5.334，P值=0.001）、自杀未遂史（HR=2.167，P值=0.003）和传统治疗史（HR=1.973262，P值=0.021）对复发危险时间有显著影响。精神分裂症的发病年龄和服药依从性并不具有预测作用。随后的复发可能取决于首次复发和之前的复发：结论：合并症、就业状况、自杀未遂史和传统治疗史是影响复发时间的重要风险因素，这些因素会增加复发风险。
{"title":"Analysis of Time to Relapse among Schizophrenia Patients in St. Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia","authors":"G. Belihu, W. Moges, Asamin Kasiye Yimer","doi":"10.31584/jhsmr.20241049","DOIUrl":"https://doi.org/10.31584/jhsmr.20241049","url":null,"abstract":"Objective: To investigate the associated factors that affect time to relapse in patients with schizophrenia at St. Amanuel Mental Specialized Hospital, with recurrent events model.Material and Methods: A hospital-based retrospective review of the medical records of 332 patient with schizophrenia, covering a two-year period, were examined. Parametric frailty models were used to determine the correlation between discharge times and relapse, and to identify risk factors using R-software. Results: The distribution number of relapses was 162, and the median survival time of patients with schizophrenia was 665 days. The unobserved heterogeneity in patients and correlation between relapses, as estimated by the Weibull-gamma frailty model, was p-value≤0.001 and Kendall’s Tau (Γ)=0.498. This indicated that there was heterogeneity among participants and a correlation between relapses. The final model showed that the effect of psychiatric comorbidity (hazard ratio (HR)=6.522, p-value≤0.001), employment status (HR=5.334, p-value=0.001), history of suicide attempt (HR=2.167, p-value=0.003) and history of traditional treatment (HR=1.973262, p-value=0.021) had a significant effect on the hazard time to relapse. Onset Age of schizophrenia and drug adherence were not predictive. Subsequent relapses are likely dependent on both the first and previous relapses.Conclusion: Comorbidity, employment status, history of suicide attempt and history of traditional treatment are imperative risk factors influencing the hazard of time to relapse, which increases the risk of relapse.","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140373797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rarinthip Boonpradit, Wanpanithan Sudsaneha, K. Khuancharee, K. Raungrongmorakot
Objective: 1) To compare the proportions of low back pain (LBP) in pregnant women with adequate and inadequate physical activity (APA and IPA, respectively) prior to pregnancy. 2) To identify possible factors associated with LBP during pregnancy. Material and Methods: A cross-sectional analytic study was conducted. Pregnant women answered questions about their physical activity prior to and during pregnancy, using the Thai version of the short International Physical Activity Questionnaire (IPAQ), and assessed their lower back pain via the visual analog scale and the Thai version of the Oswestry Disability Index (ODI). Results: A total of 342 pregnant women were enrolled. APA and IPA prior to pregnancy were detected in 172 and 170 cases, respectively. The proportions of LBP during pregnancy in each group were 61.6% and 64.7%, respectively. No statistically significant difference was found between the two groups (p-value=0.555). When adjusted with multiple factors in logistic regression model, APA prior to pregnancy decreased the risk of LBP during pregnancy (p-value=0.02), with an adjusted odds ratio (aOR) (95% CI) of 0.51 (0.281–0.916). In contrast, APA during pregnancy (p-value=0.01), pelvic pain (p-value<0.001), and LBP in a previous pregnancy (p-value<0.001) increased the risk of LBP during pregnancy, with aORs (95% CI) of 2.53 (1.236–5.197), 4.83 (2.563–9.110), and 7.49 (3.390–16.570), respectively. Conclusion: APA prior to pregnancy and limiting some types of activity during pregnancy may have a protective effect on LBP during pregnancy.
目的：1）比较怀孕前体力活动充足和体力活动不足（分别为 APA 和 IPA）的孕妇的腰背痛比例。2）确定与孕期腰背痛相关的可能因素。材料与方法：进行了一项横断面分析研究。孕妇使用泰语版的简短国际体力活动问卷（IPAQ）回答了有关孕前和孕期体力活动的问题，并通过视觉模拟量表和泰语版的奥斯韦特里残疾指数（ODI）评估了她们的下背痛情况。结果共有 342 名孕妇参加了此次研究。分别有 172 例和 170 例孕妇在怀孕前发现了 APA 和 IPA。两组孕妇在怀孕期间患腰背痛的比例分别为 61.6% 和 64.7%。两组之间没有发现明显的统计学差异（P 值=0.555）。在逻辑回归模型中对多种因素进行调整后，孕前 APA 降低了孕期枸杞痛的风险（p 值=0.02），调整后的几率比（aOR）（95% CI）为 0.51（0.281-0.916）。相反，妊娠期 APA（p-value=0.01）、骨盆疼痛（p-value<0.001）和前次妊娠枸杞痛（p-value<0.001）会增加妊娠期枸杞痛的风险，其 aOR（95% CI）分别为 2.53（1.236-5.197）、4.83（2.563-9.110）和 7.49（3.390-16.570）。结论孕前进行 APA 并在孕期限制某些类型的活动可能对孕期腰痛有保护作用。
{"title":"Association of Low Back Pain Beyond Mid-Pregnancy with Maternal Physical Activity Prior to Pregnancy: A Cross-Sectional Study","authors":"Rarinthip Boonpradit, Wanpanithan Sudsaneha, K. Khuancharee, K. Raungrongmorakot","doi":"10.31584/jhsmr.20241047","DOIUrl":"https://doi.org/10.31584/jhsmr.20241047","url":null,"abstract":"Objective: 1) To compare the proportions of low back pain (LBP) in pregnant women with adequate and inadequate physical activity (APA and IPA, respectively) prior to pregnancy. 2) To identify possible factors associated with LBP during pregnancy. Material and Methods: A cross-sectional analytic study was conducted. Pregnant women answered questions about their physical activity prior to and during pregnancy, using the Thai version of the short International Physical Activity Questionnaire (IPAQ), and assessed their lower back pain via the visual analog scale and the Thai version of the Oswestry Disability Index (ODI). Results: A total of 342 pregnant women were enrolled. APA and IPA prior to pregnancy were detected in 172 and 170 cases, respectively. The proportions of LBP during pregnancy in each group were 61.6% and 64.7%, respectively. No statistically significant difference was found between the two groups (p-value=0.555). When adjusted with multiple factors in logistic regression model, APA prior to pregnancy decreased the risk of LBP during pregnancy (p-value=0.02), with an adjusted odds ratio (aOR) (95% CI) of 0.51 (0.281–0.916). In contrast, APA during pregnancy (p-value=0.01), pelvic pain (p-value<0.001), and LBP in a previous pregnancy (p-value<0.001) increased the risk of LBP during pregnancy, with aORs (95% CI) of 2.53 (1.236–5.197), 4.83 (2.563–9.110), and 7.49 (3.390–16.570), respectively. Conclusion: APA prior to pregnancy and limiting some types of activity during pregnancy may have a protective effect on LBP during pregnancy.","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140214187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thirumurugan E, Edwin Dias, Karthick R, Kalpana Devi H, Kaza Revanth Kumar, Kamaleshwari K, Karunya A, Manisha S, Madhumitha R
Objective: The objective of this study was to evaluate the degree of hypertrophy and its geometrical patterns in hypertensive (HTN) pregnant women, with or without proteinuria.Material and Methods: Data from 88 pregnant women was analyzed., consecutively. Both clinical and echocardiographic data between normotensive and hypertensive women, with and without proteinuria, were compared.Results: Hypertensive women, with and without proteinuria, have a higher LV mass indexed by height than normotensive women (108.1±64.6 g/m vs. 76.5±24.8 g/m vs. 68.7±17.1 g/m, p-value=0.001).Conclusion: This research shows that women that suffer from pre-eclampsia and pregnancy-induced hypertension show significant subclinical remodelling of the left ventricle, encompassing structural and functional changes, compared to those with normotensive pregnant women.
研究目的本研究旨在评估有或无蛋白尿的高血压（HTN）孕妇的肥厚程度及其几何形态：连续分析了 88 名孕妇的数据。比较了正常血压和高血压（有或无蛋白尿）孕妇的临床和超声心动图数据：结果：有蛋白尿和无蛋白尿的高血压妇女的左心室质量（身高指数）均高于正常血压妇女（108.1±64.6 g/m vs. 76.5±24.8 g/m vs. 68.7±17.1 g/m，P 值=0.001）：这项研究表明，与血压正常的孕妇相比，患有先兆子痫和妊娠诱发高血压的妇女左心室会出现明显的亚临床重塑，包括结构和功能上的变化。
{"title":"Echocardiography Evaluation of the Left Ventricular Mass Index (LVMI) and Geometrical Pattern in Pre-Eclampsia and Pregnancy- Induced Hypertension Patients","authors":"Thirumurugan E, Edwin Dias, Karthick R, Kalpana Devi H, Kaza Revanth Kumar, Kamaleshwari K, Karunya A, Manisha S, Madhumitha R","doi":"10.31584/jhsmr.20241048","DOIUrl":"https://doi.org/10.31584/jhsmr.20241048","url":null,"abstract":"Objective: The objective of this study was to evaluate the degree of hypertrophy and its geometrical patterns in hypertensive (HTN) pregnant women, with or without proteinuria.Material and Methods: Data from 88 pregnant women was analyzed., consecutively. Both clinical and echocardiographic data between normotensive and hypertensive women, with and without proteinuria, were compared.Results: Hypertensive women, with and without proteinuria, have a higher LV mass indexed by height than normotensive women (108.1±64.6 g/m vs. 76.5±24.8 g/m vs. 68.7±17.1 g/m, p-value=0.001).Conclusion: This research shows that women that suffer from pre-eclampsia and pregnancy-induced hypertension show significant subclinical remodelling of the left ventricle, encompassing structural and functional changes, compared to those with normotensive pregnant women.","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140387219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Onnicha Areepongsa, K. Cattapan, Siriporn Leelakiatpaiboon, Teeravut Tubtawee, Ingporn Jiamset
Objective: Ovarian cancer is the sixth most common cancer in Thailand. Given the absence of a computed tomography (CT) score for differentiating between benign and malignant ovarian tumors, this study aimed to develop a CT scoring system for differentiating between benign and malignant ovarian tumors using pathologic findings as the reference standard.Material and Methods: This retrospective study included all female patients having undergone abdominal/pelvic CT scans for evaluation of ovarian masses at our institute, from January 2011 to December 2021. Two radiologists independently reviewed CT features and obtained a CT score for each tumor. Comparison of the differentiation performance of the CT score, with reference to the pathologic findings, was performed using Fisher’s exact or chi-squared test. The diagnostic performance of the CT score was evaluated.Results: A total of 144 patients with 191 ovarian masses were enrolled. Tumor component characteristics, septate thickness, ascites, and metastasis significantly differed between benign and malignant tumors (p-value<0.05). Multivariate logistic regression analysis showed that the presence of solid components and metastasis were significant independent differentiating factors (p-value<0.001). The CT score significantly differed between benign and malignant tumors (p-value<0.001), with 93.5% sensitivity and 81.6% specificity.Conclusion: The CT scoring system can differentiate between benign and malignant ovarian tumors with high sensitivity and specificity. Furthermore, the presence of a solid component and metastasis are CT features that can be used to differentiate between benign and malignant tumors.
{"title":"Modified Computed Tomography Scoring System for Ovarian Tumors","authors":"Onnicha Areepongsa, K. Cattapan, Siriporn Leelakiatpaiboon, Teeravut Tubtawee, Ingporn Jiamset","doi":"10.31584/jhsmr.20241045","DOIUrl":"https://doi.org/10.31584/jhsmr.20241045","url":null,"abstract":"Objective: Ovarian cancer is the sixth most common cancer in Thailand. Given the absence of a computed tomography (CT) score for differentiating between benign and malignant ovarian tumors, this study aimed to develop a CT scoring system for differentiating between benign and malignant ovarian tumors using pathologic findings as the reference standard.Material and Methods: This retrospective study included all female patients having undergone abdominal/pelvic CT scans for evaluation of ovarian masses at our institute, from January 2011 to December 2021. Two radiologists independently reviewed CT features and obtained a CT score for each tumor. Comparison of the differentiation performance of the CT score, with reference to the pathologic findings, was performed using Fisher’s exact or chi-squared test. The diagnostic performance of the CT score was evaluated.Results: A total of 144 patients with 191 ovarian masses were enrolled. Tumor component characteristics, septate thickness, ascites, and metastasis significantly differed between benign and malignant tumors (p-value<0.05). Multivariate logistic regression analysis showed that the presence of solid components and metastasis were significant independent differentiating factors (p-value<0.001). The CT score significantly differed between benign and malignant tumors (p-value<0.001), with 93.5% sensitivity and 81.6% specificity.Conclusion: The CT scoring system can differentiate between benign and malignant ovarian tumors with high sensitivity and specificity. Furthermore, the presence of a solid component and metastasis are CT features that can be used to differentiate between benign and malignant tumors.","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140221253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study aimed to investigate the preventive behaviors against coronavirus disease 2019 (COVID-19) and to identify factors influencing these behaviors. Material and Methods: We conducted a cross-sectional study from September 2021 to January 2022 during the COVID-19 outbreak. The study population comprised 320 early-onset elderly individuals with non-communicable diseases residing in rural northeastern Thailand. A simple random sampling technique was utilized to select participants. Data collection was facilitated through a self-administered questionnaire. Results: The analysis indicated that 69.1% of participants were female, with a mean age of 63.7 years. Diabetes mellitus represented 43.1% of the underlying conditions. A significant majority (54.4%) exhibited a high level of preventive behavior against COVID-19. Notably, 76.3% of the participants consistently engaged in hand hygiene with alcohol gel in public settings. Age and educational background were significant personal factors correlated with preventive behaviors (p-value<0.05). Participants with very high preventive behaviors were predominantly in the 60-65 age bracket (62.3% vs. 37.7%, p-value=0.027) and had completed late elementary education (46.0% vs. 30.1%, p-value=0.018). Conclusion: Elderly individuals with underlying diseases in rural areas of northeastern Thailand displayed commendable preventive behaviors against COVID-19. These findings suggest a heightened awareness and proactive engagement in mitigating the transmission of this infectious disease.
{"title":"Behavior to Prevent Coronavirus Disease 2019 (COVID-19) among the Elderly with Non-Communicable Disease in Rural Northeastern Thailand","authors":"Kaewjai Maleelai, Nichaphat Phudket, Pridaporn Rittiron","doi":"10.31584/jhsmr.20241046","DOIUrl":"https://doi.org/10.31584/jhsmr.20241046","url":null,"abstract":"Objective: This study aimed to investigate the preventive behaviors against coronavirus disease 2019 (COVID-19) and to identify factors influencing these behaviors. Material and Methods: We conducted a cross-sectional study from September 2021 to January 2022 during the COVID-19 outbreak. The study population comprised 320 early-onset elderly individuals with non-communicable diseases residing in rural northeastern Thailand. A simple random sampling technique was utilized to select participants. Data collection was facilitated through a self-administered questionnaire. Results: The analysis indicated that 69.1% of participants were female, with a mean age of 63.7 years. Diabetes mellitus represented 43.1% of the underlying conditions. A significant majority (54.4%) exhibited a high level of preventive behavior against COVID-19. Notably, 76.3% of the participants consistently engaged in hand hygiene with alcohol gel in public settings. Age and educational background were significant personal factors correlated with preventive behaviors (p-value<0.05). Participants with very high preventive behaviors were predominantly in the 60-65 age bracket (62.3% vs. 37.7%, p-value=0.027) and had completed late elementary education (46.0% vs. 30.1%, p-value=0.018). Conclusion: Elderly individuals with underlying diseases in rural areas of northeastern Thailand displayed commendable preventive behaviors against COVID-19. These findings suggest a heightened awareness and proactive engagement in mitigating the transmission of this infectious disease.","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140223225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Kurniati, Ari Utariani, I. Syafa'ah, R. Setiawati, Anita Widyoningroem, Firly Hayati
Objective: Coronavirus disease 2019 (COVID-19) became a global pandemic, with high mortality in severely ill patients. This study aimed to develop a novel scoring system to prognosticate disease severity in COVID-19 patients that is effective and widely available in tertiary medical resource settings.Material and Methods: Laboratory-confirmed COVID-19 patients were enrolled in this retrospective cohort, divided into severe and non-severe groups. We randomly assigned 70% of the subjects to establish a novel scoring system, while the remaining 30% was used for internal validation. The model was constructed by multivariate logistic regression using the first clinical, laboratory, and radiological finding of statistically analysis of group patients. receiver operating characteristic (ROC) and cross-tabulation were used to evaluate the performance of our score and compare it with other models.Results: A total of 599 patients were included. The Soetomo COVID-19 prognostic score predictors included age, fever, specific comorbidities (diabetes, hypertension, cardiac disease, lung tuberculosis), respiratory rate, heart rate, SF ratio, whole blood cell (WBC) count, neutrophil lympocyte ratio (NLR), blood urea nitrogen (BUN), and a RALE score. The area under the ROC of the model indicated an excellent discriminatory ability (training datasets 0.715 [95% CI 0.664-0.767, p-value<0.001]; testing datasets 0.720 [95% CI 0.638-0.802, p-value<0.001]). Our scoring system was superior to both qSOFA and MEWS regarding predictive value. The sensitivity and specificity were 60.6% and 82.5%, respectively.Conclusion: The developed scoring system accurately predicted a significant proportion of severe disease in COVID-19 patients.
{"title":"Soetomo COVID-19 Prognostic Score: A Multi-Parametric Model for Early Prediction of Disease Severity of COVID-19 in Tertiery -Resource Hospital","authors":"N. Kurniati, Ari Utariani, I. Syafa'ah, R. Setiawati, Anita Widyoningroem, Firly Hayati","doi":"10.31584/jhsmr.20241044","DOIUrl":"https://doi.org/10.31584/jhsmr.20241044","url":null,"abstract":"Objective: Coronavirus disease 2019 (COVID-19) became a global pandemic, with high mortality in severely ill patients. This study aimed to develop a novel scoring system to prognosticate disease severity in COVID-19 patients that is effective and widely available in tertiary medical resource settings.Material and Methods: Laboratory-confirmed COVID-19 patients were enrolled in this retrospective cohort, divided into severe and non-severe groups. We randomly assigned 70% of the subjects to establish a novel scoring system, while the remaining 30% was used for internal validation. The model was constructed by multivariate logistic regression using the first clinical, laboratory, and radiological finding of statistically analysis of group patients. receiver operating characteristic (ROC) and cross-tabulation were used to evaluate the performance of our score and compare it with other models.Results: A total of 599 patients were included. The Soetomo COVID-19 prognostic score predictors included age, fever, specific comorbidities (diabetes, hypertension, cardiac disease, lung tuberculosis), respiratory rate, heart rate, SF ratio, whole blood cell (WBC) count, neutrophil lympocyte ratio (NLR), blood urea nitrogen (BUN), and a RALE score. The area under the ROC of the model indicated an excellent discriminatory ability (training datasets 0.715 [95% CI 0.664-0.767, p-value<0.001]; testing datasets 0.720 [95% CI 0.638-0.802, p-value<0.001]). Our scoring system was superior to both qSOFA and MEWS regarding predictive value. The sensitivity and specificity were 60.6% and 82.5%, respectively.Conclusion: The developed scoring system accurately predicted a significant proportion of severe disease in COVID-19 patients.","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140224668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study aimed to investigate the effect of task-based mirror therapy on upper extremity function, and daily living activities in individuals with stroke, after four weeks of training. Material and Methods: Participants were randomized into two groups, the task-based mirror therapy group and the task training as the control group: as 10 and 7 participants, respectively. The Action Research Arm Test (ARAT), the Fugl-Meyer Assessment (FMA), the Sirindhorn National Medical Rehabilitation Center Functional Assessment (SNMRC) and the Short-Form 36 (SF-36) were assessed before and after training, over a four week period. Results: The results showed that the home-based programs of both the task-based mirror therapy and the control group improved on all variables, but without statistical significance between groups. However, within group analysis, the task-based mirror therapy group exhibited significant differences between pre- and post-assessments for FMA; whereas, the control group did not. Conclusion: The home-based program of task-based mirror therapy, as a task-specific training approach, has demonstrated the potential to enhance the recovery of upper limb motor function after a four-week training period.
{"title":"Effect of Home-Based Task-Based Mirror Therapy on Upper Extremity Function in Stroke Patients: A Four-Week Intervention Study","authors":"Jaruwan Prasomsri, Pakamas Jearudomsup, Watcharaporn Pratheep Na Talang, Nutchanart Madadam, Achiraya Plodauksorn, Khammissara Ratchatapan, Warinporn Sukcharoen, Sirinya Warinkaew, Chatit Wichitphong, Sobariyah Hama, Sanusee Bensa-ed","doi":"10.31584/jhsmr.20241042","DOIUrl":"https://doi.org/10.31584/jhsmr.20241042","url":null,"abstract":"Objective: This study aimed to investigate the effect of task-based mirror therapy on upper extremity function, and daily living activities in individuals with stroke, after four weeks of training. Material and Methods: Participants were randomized into two groups, the task-based mirror therapy group and the task training as the control group: as 10 and 7 participants, respectively. The Action Research Arm Test (ARAT), the Fugl-Meyer Assessment (FMA), the Sirindhorn National Medical Rehabilitation Center Functional Assessment (SNMRC) and the Short-Form 36 (SF-36) were assessed before and after training, over a four week period. Results: The results showed that the home-based programs of both the task-based mirror therapy and the control group improved on all variables, but without statistical significance between groups. However, within group analysis, the task-based mirror therapy group exhibited significant differences between pre- and post-assessments for FMA; whereas, the control group did not. Conclusion: The home-based program of task-based mirror therapy, as a task-specific training approach, has demonstrated the potential to enhance the recovery of upper limb motor function after a four-week training period.","PeriodicalId":36211,"journal":{"name":"Journal of Health Science and Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140241937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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