Pub Date : 2020-03-08DOI: 10.3760/CMA.J.ISSN.0254-5098.2020.0006
Huan Wang, Bo Wu, Liying Xu, Haibo Xu
Since the outbreak of new coronavirus infection (COVID-19) in Wuhan, Hubei in December 2019, a total of 80 424 patients have been diagnosed (as of March 3, 2020), which has caused significant inpact in national health and economics. the Square Cabin Hospital, which played a vital role in effectively controlling the source of infection and cutting off the transmission channels. Compared with the CT room in a conventional hospital, the square cabin CT is very different in terms of infection area settings, protective isolation measures and inspection procedures. This article summarizes aspects of CT room design, staffing responsibilities, division of infected areas, inspection procedures, protection and disinfection, etc. Key words: Coronavirus disease (COVID-19); Square cabin CT; Workflow; Standardized Scan; Occupational safety and health
{"title":"Experience about workflow of standardized square cabin CT scan in field hospital during the outbreak of COVID-19","authors":"Huan Wang, Bo Wu, Liying Xu, Haibo Xu","doi":"10.3760/CMA.J.ISSN.0254-5098.2020.0006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2020.0006","url":null,"abstract":"Since the outbreak of new coronavirus infection (COVID-19) in Wuhan, Hubei in December 2019, a total of 80 424 patients have been diagnosed (as of March 3, 2020), which has caused significant inpact in national health and economics. the Square Cabin Hospital, which played a vital role in effectively controlling the source of infection and cutting off the transmission channels. Compared with the CT room in a conventional hospital, the square cabin CT is very different in terms of infection area settings, protective isolation measures and inspection procedures. This article summarizes aspects of CT room design, staffing responsibilities, division of infected areas, inspection procedures, protection and disinfection, etc. \u0000 \u0000Key words: \u0000Coronavirus disease (COVID-19); Square cabin CT; Workflow; Standardized Scan; Occupational safety and health","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"93 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81059043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-01DOI: 10.3760/CMA.J.ISSN.0254-5098.2020.0005
Jin Wang, B. Zhu, Chunyong Yang, Wei Chen, Jiayi Ma, Ningle Yu
X-ray imaging is an important method for the diagnosis of corona virus disease(COVID-19), but there is a risk of nosocomial infection during X-ray imaging diagnosis. By analyzing the process of X-ray imaging diagnosis and the possible infection factors in hospital, Jiangsu province took the lead in issuing the Guideline for the nosocomial infection prevention and control of X-ray imaging diagnosis of COVID-19. This guideline clarifies the basic requirements for controlling infections during X-ray imaging diagnosis, the specific measures for staff protection, disinfection of personnel and places, and the protection and disinfection of subjects, which is instructive for field work. It is worth noting that while focusing on controlling infections, the principle of optimal protection for medical exposure cannot be ignored.
{"title":"Procedures of health protection and control for COVID-19 during X-ray imaging examinations in Jiangsu province/ 中华放射医学与防护杂志","authors":"Jin Wang, B. Zhu, Chunyong Yang, Wei Chen, Jiayi Ma, Ningle Yu","doi":"10.3760/CMA.J.ISSN.0254-5098.2020.0005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2020.0005","url":null,"abstract":"X-ray imaging is an important method for the diagnosis of corona virus disease(COVID-19), but there is a risk of nosocomial infection during X-ray imaging diagnosis. By analyzing the process of X-ray imaging diagnosis and the possible infection factors in hospital, Jiangsu province took the lead in issuing the Guideline for the nosocomial infection prevention and control of X-ray imaging diagnosis of COVID-19. This guideline clarifies the basic requirements for controlling infections during X-ray imaging diagnosis, the specific measures for staff protection, disinfection of personnel and places, and the protection and disinfection of subjects, which is instructive for field work. It is worth noting that while focusing on controlling infections, the principle of optimal protection for medical exposure cannot be ignored.","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81811822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-01DOI: 10.3760/CMA.J.ISSN.0254-5098.2020.0004
T. Song, Hong’en Xu, Qiang Li, Long Chen, M. Fang, Yong-shi Jia, Xiaodong Liang, Weijun Chen, Shuqiang Wu, Baihua Lin, M. Yuan
To explore the clinical practice of delivering radiotherapy during the outbreak of 2019 novel coronavirus disease(COVID-19) ;;Methods;During this epidemic period, available methods including but not limited to: strict disinfection, body temperature monitoring, learning relevant knowledge by all staffs to ensure the safety of radiotherapy treatment Relevant data including proportion of radiotherapy, time from scanning to the first time of radiation delivery and degree of satisfaction in the view of staffs and patients, respectively ;;Results;A total of 60 patients received radiation therapy in the department of radiotherapy of Zhejiang Provincial Peoplers Hospital (2020-02-11) Compared with the same period in 2019 (after the Spring Festival), the total number of patients receiving radiotherapy was decreased from 72 to 60(83 3%) Among them, the number of patients receiving palliative radiation therapy decreased significantly, while the proportion of radical, preoperative and/or postoperative radiotherapy/radiochemotherapy did not significantly decrease There was significant difference between different years (litalicgcl/italicglsupg2l/supg=6 967, litalicgPl/italicgl0 05) The median time for newly admitted patients to receive radiotherapy was two days, which was not significantly longer than the interval in 2019 (litalicgPl/italicgg0 05) Staffs and patients were generally satisfied with the current prevention measures ;;Conclusions;Using a variety of prevention and control methods, and taking full account of medical safety and patient benefits, radiation-related activities can be carried out during the epidemic ;
{"title":"Implementation of radiotherapy in a tertiary hospital in Zhejiang province during the epidemic of COVID-19","authors":"T. Song, Hong’en Xu, Qiang Li, Long Chen, M. Fang, Yong-shi Jia, Xiaodong Liang, Weijun Chen, Shuqiang Wu, Baihua Lin, M. Yuan","doi":"10.3760/CMA.J.ISSN.0254-5098.2020.0004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2020.0004","url":null,"abstract":"To explore the clinical practice of delivering radiotherapy during the outbreak of 2019 novel coronavirus disease(COVID-19) ;;Methods;During this epidemic period, available methods including but not limited to: strict disinfection, body temperature monitoring, learning relevant knowledge by all staffs to ensure the safety of radiotherapy treatment Relevant data including proportion of radiotherapy, time from scanning to the first time of radiation delivery and degree of satisfaction in the view of staffs and patients, respectively ;;Results;A total of 60 patients received radiation therapy in the department of radiotherapy of Zhejiang Provincial Peoplers Hospital (2020-02-11) Compared with the same period in 2019 (after the Spring Festival), the total number of patients receiving radiotherapy was decreased from 72 to 60(83 3%) Among them, the number of patients receiving palliative radiation therapy decreased significantly, while the proportion of radical, preoperative and/or postoperative radiotherapy/radiochemotherapy did not significantly decrease There was significant difference between different years (litalicgcl/italicglsupg2l/supg=6 967, litalicgPl/italicgl0 05) The median time for newly admitted patients to receive radiotherapy was two days, which was not significantly longer than the interval in 2019 (litalicgPl/italicgg0 05) Staffs and patients were generally satisfied with the current prevention measures ;;Conclusions;Using a variety of prevention and control methods, and taking full account of medical safety and patient benefits, radiation-related activities can be carried out during the epidemic ;","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"13 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78379004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-25DOI: 10.3760/CMA.J.ISSN.0254-5098.2020.02.015
Yating Niu, Yinping Su, Y. Niu, Q. Sun
The article briefly described the frequency of CT scans and the development trend of CT exposure doses in children, and introduced the main method and achievements in the cancer risk evaluation of pediatric CT scans in different time periods. This review will provide the references for optimizing the radiation dose of CT scans. Key words: CT scan; Pediatric; Cancer risk; Epidemiology
{"title":"A review of the long-term cancer risk of CT scans in children","authors":"Yating Niu, Yinping Su, Y. Niu, Q. Sun","doi":"10.3760/CMA.J.ISSN.0254-5098.2020.02.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2020.02.015","url":null,"abstract":"The article briefly described the frequency of CT scans and the development trend of CT exposure doses in children, and introduced the main method and achievements in the cancer risk evaluation of pediatric CT scans in different time periods. This review will provide the references for optimizing the radiation dose of CT scans. \u0000 \u0000 \u0000Key words: \u0000CT scan; Pediatric; Cancer risk; Epidemiology","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"71 1","pages":"156-160"},"PeriodicalIF":0.0,"publicationDate":"2020-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85920866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To establish radiomics models based on different CT scaning phases to distinguish mediastinal metastatic lymph nodes in NSCLC and to explore the diagnostic efficacy of these models. Methods The CT images of 86 preoperative patients with NSCLC who were performed both plain and enhanced CT scans were analyzed retrospectively. The 231 mediastinal lymph nodes were enrolled in this study which were divided into two independent cohorts: 163 lymph nodes enrolled from January 2015 to June 2017 constituted the training cohort, and 68 lymph nodes enrolled from July 2017 to June 2018 constituted the validation cohort. The regions of interest (ROIs) were delineated on plain scan phase, arterial phase and venous phase CT images respectively, and 841 features were extracted from each ROI. LASSO-logistic regression analysis was used to select features and develop models. The area under the ROC curve (AUC value), sensitivity, specificity, accuracy, positive predictive value and negative predictive value of different models for distinguishing metastatic lymph nodes were compared. Results A total of 6 models were established, and the AUC values were all greater than 0.800. The plain CT model yielded the highest AUC, specificity, accuracy and positive predictive value with 0.926, 0.860, 0.871, 0.906 in the training cohort and 0.925, 0.769, 0.882, 0.870 in the validation cohort. When plain and venous phase CT images were combined with arterial phase CT images, the sensitivity and negative predictive value of the models increased from 0.879, 0.821 and 0.919, 0.789 to 0.949, 0.878 and 0.979, 0.900 respectively. Conclusions The CT radiomics model could be used to assist the clinical diagnosis of lymph nodes. The AUC value of the model based on plain scanning was the highest, while the sensitivity and negative predictive value of the model could be improved by combining the arterial phase CT images. Key words: Non-small cell lung cancer; Computed tomography; Radiomics; Mediastinum lymph node
{"title":"A model study of diagnosing mediastinal metastasis lymph nodes in non-small cell lung cancer based on CT radiomics","authors":"Xue Sha, G. Gong, Qingtao Qiu, Zhenjiang Li, Dengwang Li, Yong Yin","doi":"10.3760/CMA.J.ISSN.0254-5098.2020.02.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2020.02.014","url":null,"abstract":"Objective \u0000To establish radiomics models based on different CT scaning phases to distinguish mediastinal metastatic lymph nodes in NSCLC and to explore the diagnostic efficacy of these models. \u0000 \u0000 \u0000Methods \u0000The CT images of 86 preoperative patients with NSCLC who were performed both plain and enhanced CT scans were analyzed retrospectively. The 231 mediastinal lymph nodes were enrolled in this study which were divided into two independent cohorts: 163 lymph nodes enrolled from January 2015 to June 2017 constituted the training cohort, and 68 lymph nodes enrolled from July 2017 to June 2018 constituted the validation cohort. The regions of interest (ROIs) were delineated on plain scan phase, arterial phase and venous phase CT images respectively, and 841 features were extracted from each ROI. LASSO-logistic regression analysis was used to select features and develop models. The area under the ROC curve (AUC value), sensitivity, specificity, accuracy, positive predictive value and negative predictive value of different models for distinguishing metastatic lymph nodes were compared. \u0000 \u0000 \u0000Results \u0000A total of 6 models were established, and the AUC values were all greater than 0.800. The plain CT model yielded the highest AUC, specificity, accuracy and positive predictive value with 0.926, 0.860, 0.871, 0.906 in the training cohort and 0.925, 0.769, 0.882, 0.870 in the validation cohort. When plain and venous phase CT images were combined with arterial phase CT images, the sensitivity and negative predictive value of the models increased from 0.879, 0.821 and 0.919, 0.789 to 0.949, 0.878 and 0.979, 0.900 respectively. \u0000 \u0000 \u0000Conclusions \u0000The CT radiomics model could be used to assist the clinical diagnosis of lymph nodes. The AUC value of the model based on plain scanning was the highest, while the sensitivity and negative predictive value of the model could be improved by combining the arterial phase CT images. \u0000 \u0000 \u0000Key words: \u0000Non-small cell lung cancer; Computed tomography; Radiomics; Mediastinum lymph node","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"102 1","pages":"150-155"},"PeriodicalIF":0.0,"publicationDate":"2020-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84027130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-25DOI: 10.3760/CMA.J.ISSN.0254-5098.2020.02.008
Hongli Zhao, Ying Chen, Xiaoyong Wang, Hongyan Zhang, Y. Zhong, Hui Liu
Objective To investigate the dosimetry differences of target and OARs of an integrated design of fields in IMRT and the mainstream IMRT technique for post-radical mastectomy. Methods A total of 41 patients with post-radical mastectomy who received IMRT were eligible, the conventional fixing two-degrade collimator and the integrated IMRT fields were designed respectively. The dosimetry parameters of target and OARs, monitor units and delivery time of both plans were compared. Results The dose distribution for targets and OARs of both plans met clinical requirements. The dosimetry parameters of target of both plans showed no statistically significant difference (P>0.05). Compared with the conventional technique, the integrated IMRT plans showed significant advantages, the ipsilateral lung V5 decreased by 9.7%(t=2.407, P 0.05). Conclusions The new method can effectively reduce exposed volume and exposed dose of ipsilateral lung and heart without affecting the target dose coverage. The method has universal applicability to patients with post-radical mastectomy who received IMRT, with important clinical significance. Key words: Post-radical mastectomy; Intensity-modulated radiation therapy; OARS; Long-term cardiac disease; Clinical application
{"title":"An integrated design of fields in IMRT for post-radical mastectomy","authors":"Hongli Zhao, Ying Chen, Xiaoyong Wang, Hongyan Zhang, Y. Zhong, Hui Liu","doi":"10.3760/CMA.J.ISSN.0254-5098.2020.02.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2020.02.008","url":null,"abstract":"Objective \u0000To investigate the dosimetry differences of target and OARs of an integrated design of fields in IMRT and the mainstream IMRT technique for post-radical mastectomy. \u0000 \u0000 \u0000Methods \u0000A total of 41 patients with post-radical mastectomy who received IMRT were eligible, the conventional fixing two-degrade collimator and the integrated IMRT fields were designed respectively. The dosimetry parameters of target and OARs, monitor units and delivery time of both plans were compared. \u0000 \u0000 \u0000Results \u0000The dose distribution for targets and OARs of both plans met clinical requirements. The dosimetry parameters of target of both plans showed no statistically significant difference (P>0.05). Compared with the conventional technique, the integrated IMRT plans showed significant advantages, the ipsilateral lung V5 decreased by 9.7%(t=2.407, P 0.05). \u0000 \u0000 \u0000Conclusions \u0000The new method can effectively reduce exposed volume and exposed dose of ipsilateral lung and heart without affecting the target dose coverage. The method has universal applicability to patients with post-radical mastectomy who received IMRT, with important clinical significance. \u0000 \u0000 \u0000Key words: \u0000Post-radical mastectomy; Intensity-modulated radiation therapy; OARS; Long-term cardiac disease; Clinical application","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"74 1","pages":"116-121"},"PeriodicalIF":0.0,"publicationDate":"2020-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89416643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-25DOI: 10.3760/CMA.J.ISSN.0254-5098.2020.02.009
S. Luo, Hao Wu, Zhi-jian He, Xian Xue, Ji-long Yuan
Objective To develop the methodology for using TLD and radiochromic film to measure the planned target volume (PTV) and organ at risk (OAR) doses and 2D dose distribution in IMRT, in order to provide technical guidance on the dose quality audit in IMRT at home. Methods China has participated in the research project launched by the international multi-radiotherapy centre (IMRC). IMRT polystyrene phantom provided by IAEA was scanned by CT scanner and then the scanned images were transmitted to TPS to outline prescribed dose to PTV and to OAR. The former was limited to 400 cGy while the latter limited to 200 cGy. IMRT was implemented with the phantom irradiated using 6 MV X-ray. The irradiated TLDs and films were sent to IAEA dosimerty laboratory for measurement and calculation. Jiangsu, Sichuan, Hubei and Henan provinces were selected to engage with this study for their variety of accelerators and highly skilled physicists. The procedures used were the same as in the IMRC and the irradiated TLDs and films were required to send to external audit group for measurement and calculation. Results According to IAEA requirement, the relative deviations of the TLD-measured and TPS planned doses are within ±7.0% for PTV and OAR. The China′s research results at the IMRC have shown that the relative deviation of TLD-measured and TPS-planned values for the upper and lower PTV were -0.2% and 0.8%, respectively, consistent with the IAEA requirement, and the values for upper and lower OAR were -0.6% and -1.0%, respectively, consistent with the requirement. As the results have shown in four provinces, the relative deviations of the TLD-measured and TPS-planned were within 0 to 10.6% for upper and lower PTV and -0.6% to 20.9% for upper and lower OAR. According to IAEA requirement, the passing rate should be greater than 90% for 3 mm /3% for 2D dose distribution. China′s result at the IMRC is 100%, being excellent. The four provinces′ results have shown that 2D dose distribution pass rate of 3 mm/3% was in the range of 45.0%-100.0%. Conclusions The uses of TLD in quality audit for PTV and OAR doses and the radiochromic film in 2D dose distribution pass rate in IMRT are characterized by scientific feasibility, strong operability, easy-to-mail and data realibility. They are can be applied to quality assurance and audit in medical institutions in the country to on a large scale. Key words: Intensity modulated radiation therapy; Radiochromic film; Planned target volume; Organ at risk; Two-dimensional dose distribution
{"title":"Development of methodology for quality audit of doses in target area and organ at risk and two dimensional dose distribution in intensity modulated radiotherapy","authors":"S. Luo, Hao Wu, Zhi-jian He, Xian Xue, Ji-long Yuan","doi":"10.3760/CMA.J.ISSN.0254-5098.2020.02.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2020.02.009","url":null,"abstract":"Objective \u0000To develop the methodology for using TLD and radiochromic film to measure the planned target volume (PTV) and organ at risk (OAR) doses and 2D dose distribution in IMRT, in order to provide technical guidance on the dose quality audit in IMRT at home. \u0000 \u0000 \u0000Methods \u0000China has participated in the research project launched by the international multi-radiotherapy centre (IMRC). IMRT polystyrene phantom provided by IAEA was scanned by CT scanner and then the scanned images were transmitted to TPS to outline prescribed dose to PTV and to OAR. The former was limited to 400 cGy while the latter limited to 200 cGy. IMRT was implemented with the phantom irradiated using 6 MV X-ray. The irradiated TLDs and films were sent to IAEA dosimerty laboratory for measurement and calculation. Jiangsu, Sichuan, Hubei and Henan provinces were selected to engage with this study for their variety of accelerators and highly skilled physicists. The procedures used were the same as in the IMRC and the irradiated TLDs and films were required to send to external audit group for measurement and calculation. \u0000 \u0000 \u0000Results \u0000According to IAEA requirement, the relative deviations of the TLD-measured and TPS planned doses are within ±7.0% for PTV and OAR. The China′s research results at the IMRC have shown that the relative deviation of TLD-measured and TPS-planned values for the upper and lower PTV were -0.2% and 0.8%, respectively, consistent with the IAEA requirement, and the values for upper and lower OAR were -0.6% and -1.0%, respectively, consistent with the requirement. As the results have shown in four provinces, the relative deviations of the TLD-measured and TPS-planned were within 0 to 10.6% for upper and lower PTV and -0.6% to 20.9% for upper and lower OAR. According to IAEA requirement, the passing rate should be greater than 90% for 3 mm /3% for 2D dose distribution. China′s result at the IMRC is 100%, being excellent. The four provinces′ results have shown that 2D dose distribution pass rate of 3 mm/3% was in the range of 45.0%-100.0%. \u0000 \u0000 \u0000Conclusions \u0000The uses of TLD in quality audit for PTV and OAR doses and the radiochromic film in 2D dose distribution pass rate in IMRT are characterized by scientific feasibility, strong operability, easy-to-mail and data realibility. They are can be applied to quality assurance and audit in medical institutions in the country to on a large scale. \u0000 \u0000 \u0000Key words: \u0000Intensity modulated radiation therapy; Radiochromic film; Planned target volume; Organ at risk; Two-dimensional dose distribution","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"40 1","pages":"122-128"},"PeriodicalIF":0.0,"publicationDate":"2020-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75373202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-25DOI: 10.3760/CMA.J.ISSN.0254-5098.2020.02.006
Chunyan Song, Shuchai Zhu, W. Shen, Jing-wei Su, Sina Gao, Yan Zhao, Jinrui Xu, Shu-guang Li
Objective To study the relationship between the dose-volume indexes and acute toxicity of intrathoracic stomach in esophageal cancer patients receiving radiotherapy after esophagectomy. Methods A total of 104 patients treated with postoperative radiotherapy followed by radical esophagectomy were enrolled. The dose-volume indexes of intrathoracic stomach were collected from treatment planning system. The ROC curve and logistic regression were performed to analyze the relationship between acute toxicity of intrathoracic stomach and clinical parameters, dose-volume indexes. Results A total of 29 patients (27.88 %) suffered from grade 2 or above acute toxicity. The ROC curve analysis showed that the dose-volume indexes including Dmax, Dmean, L5-L45 and V5-V50were associated with occurrence of grade 2 or above acute toxicity. The univariate analysis showed that location, Dmax, Dmean, L5-L45 and V5-V50 were significantly correlated with the incidence of grade 2 or above acute toxicity (P 14.00 cm and 38.64% for L5≥14.00 cm (χ2=4.473, P<0.05), 14.08% for V35<44.00% and 57.58% for V35≥44.00% (χ2=7.263, P<0.05), respectively. The incidence of grade 2 or above acute toxicity was significantly higher in post-mediastinum stomach group than the other two groups (χ2=12.881, P<0.05). Conclusions Dose-volume index may be indicator to predict acute toxicity of intrathoracic stomach. It is recommended that post-mediastinum stomach should be chosen carefully if esophageal cancer patients require postoperative radiotherapy. Key words: Esophageal carcinoma; Operation; Intrathoracic stomach irradiation injury; Dose-volume indexes
目的探讨食管癌患者食管切除术后放疗的剂量-容量指标与胸内胃急性毒性的关系。方法对104例术后放疗合并根治性食管切除术患者进行回顾性分析。从治疗计划系统中采集胸内胃剂量-体积指标。采用ROC曲线和logistic回归分析胸内胃急性毒性与临床参数、剂量-体积指标的关系。结果2级及以上急性毒性29例(27.88%)。ROC曲线分析显示，Dmax、Dmean、L5-L45、v5 - v50等剂量-体积指标与2级及以上急性毒性的发生相关。单因素分析显示，部位、Dmax、Dmean、L5- l45、V5-V50与2级及以上急性毒性发生率显著相关(L5≥14.00 cm为14.00 cm, V35≥44.00%为14.08%，V35≥44.00%为57.58%，χ2=7.263, P<0.05)，差异有统计学意义(χ2=4.473, P<0.05)。纵隔后胃组2级及以上急性毒性发生率显著高于其他两组(χ2=12.881, P<0.05)。结论剂量-体积指数可作为预测胸内胃急性毒性的指标。食管癌患者术后需要放疗时，建议慎重选择纵隔后胃。关键词:食管癌;操作;胸内胃辐照损伤;Dose-volume索引
{"title":"The relationship between the dose-volume indexes and acute toxicity of intrathoracic stomach in esophageal cancer patients receiving radiotherapy after esophagectomy","authors":"Chunyan Song, Shuchai Zhu, W. Shen, Jing-wei Su, Sina Gao, Yan Zhao, Jinrui Xu, Shu-guang Li","doi":"10.3760/CMA.J.ISSN.0254-5098.2020.02.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2020.02.006","url":null,"abstract":"Objective \u0000To study the relationship between the dose-volume indexes and acute toxicity of intrathoracic stomach in esophageal cancer patients receiving radiotherapy after esophagectomy. \u0000 \u0000 \u0000Methods \u0000A total of 104 patients treated with postoperative radiotherapy followed by radical esophagectomy were enrolled. The dose-volume indexes of intrathoracic stomach were collected from treatment planning system. The ROC curve and logistic regression were performed to analyze the relationship between acute toxicity of intrathoracic stomach and clinical parameters, dose-volume indexes. \u0000 \u0000 \u0000Results \u0000A total of 29 patients (27.88 %) suffered from grade 2 or above acute toxicity. The ROC curve analysis showed that the dose-volume indexes including Dmax, Dmean, L5-L45 and V5-V50were associated with occurrence of grade 2 or above acute toxicity. The univariate analysis showed that location, Dmax, Dmean, L5-L45 and V5-V50 were significantly correlated with the incidence of grade 2 or above acute toxicity (P 14.00 cm and 38.64% for L5≥14.00 cm (χ2=4.473, P<0.05), 14.08% for V35<44.00% and 57.58% for V35≥44.00% (χ2=7.263, P<0.05), respectively. The incidence of grade 2 or above acute toxicity was significantly higher in post-mediastinum stomach group than the other two groups (χ2=12.881, P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Dose-volume index may be indicator to predict acute toxicity of intrathoracic stomach. It is recommended that post-mediastinum stomach should be chosen carefully if esophageal cancer patients require postoperative radiotherapy. \u0000 \u0000 \u0000Key words: \u0000Esophageal carcinoma; Operation; Intrathoracic stomach irradiation injury; Dose-volume indexes","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"1 1","pages":"106-111"},"PeriodicalIF":0.0,"publicationDate":"2020-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77368911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-25DOI: 10.3760/CMA.J.ISSN.0254-5098.2020.02.003
C. Liu, X. Dong, Yuanhang Li, Xinqiang Zhang, Zhicheng Wang, Gang Zhao
Objective To investigate whether silencing UCP2 can sensitize cervical cancer cell line Siha to radiation. Methods Siha cells were transfected with UCP2 siRNA and then irradiated by X-ray. The radiosensitivity of Siha cells was verified by colony formation, CCK-8, apoptosis and immunofluorescence assays. The mitochondrial membrane potential and the production of reactive oxygen species (ROS) were detected to further explore the related mechanism. Results RT-PCR and Western blot assays showed that the expression of UCP2 in Siha cells was increased after irradiation and the UCP2 siRNA successfully silenced the expression of UCP in cells. According to the survival curves, the D0, Dq, N and SF2 were 1.54, 1.31, 2.31 Gy and 0.52 for siUCP2 group, 2.50, 3.64, 4.30 Gy and 0.83 for blank control group, and 3.34, 2.16, 1.91 Gy and 0.69, for siNC group, respectively. The radiosensitivity enhancement ratio of silent group was 0.62 and 0.46, compared with blank control group and negative control group, respectively. The proliferative activity of cells in the silent group was lower than that in the control group (t=13.2, P<0.05). Apoptosis levels in the silent group were significantly higher than those in the control group after irradiation(t=3.14, P<0.05). At 4 h after irradiation, the ROS production in the silent group was significantly higher than that in the control group (t=19.10, P<0.05). At 24 h after irradiation, the mitochondrial membrane potential of Siha cells in the silent group was significantly lower than that in the control group (t=4.18, P<0.05). Conclusions The radiosensitivity of Siha cells is enhanced after UCP2 silencing, and thus UCP2 may applicable as a new target for radiosensitization of cervical cancer cells. Key words: Cervical cancer; RNA interference; Uncoupling protein 2; Apoptosis; Radiation sensitivity
{"title":"Effect of uncoupling protein 2 gene on radiation sensitivity of Siha cells","authors":"C. Liu, X. Dong, Yuanhang Li, Xinqiang Zhang, Zhicheng Wang, Gang Zhao","doi":"10.3760/CMA.J.ISSN.0254-5098.2020.02.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2020.02.003","url":null,"abstract":"Objective To investigate whether silencing UCP2 can sensitize cervical cancer cell line Siha to radiation. Methods Siha cells were transfected with UCP2 siRNA and then irradiated by X-ray. The radiosensitivity of Siha cells was verified by colony formation, CCK-8, apoptosis and immunofluorescence assays. The mitochondrial membrane potential and the production of reactive oxygen species (ROS) were detected to further explore the related mechanism. Results RT-PCR and Western blot assays showed that the expression of UCP2 in Siha cells was increased after irradiation and the UCP2 siRNA successfully silenced the expression of UCP in cells. According to the survival curves, the D0, Dq, N and SF2 were 1.54, 1.31, 2.31 Gy and 0.52 for siUCP2 group, 2.50, 3.64, 4.30 Gy and 0.83 for blank control group, and 3.34, 2.16, 1.91 Gy and 0.69, for siNC group, respectively. The radiosensitivity enhancement ratio of silent group was 0.62 and 0.46, compared with blank control group and negative control group, respectively. The proliferative activity of cells in the silent group was lower than that in the control group (t=13.2, P<0.05). Apoptosis levels in the silent group were significantly higher than those in the control group after irradiation(t=3.14, P<0.05). At 4 h after irradiation, the ROS production in the silent group was significantly higher than that in the control group (t=19.10, P<0.05). At 24 h after irradiation, the mitochondrial membrane potential of Siha cells in the silent group was significantly lower than that in the control group (t=4.18, P<0.05). Conclusions The radiosensitivity of Siha cells is enhanced after UCP2 silencing, and thus UCP2 may applicable as a new target for radiosensitization of cervical cancer cells. Key words: Cervical cancer; RNA interference; Uncoupling protein 2; Apoptosis; Radiation sensitivity","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"26 1","pages":"88-93"},"PeriodicalIF":0.0,"publicationDate":"2020-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80995794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-25DOI: 10.3760/CMA.J.ISSN.0254-5098.2020.02.010
Chunyong Yang, Yuanyuan Zhou, Xingjiang Cao, Xiang Du, S. Luo, Xian Xue, Zhi-jian He, Jin Wang
Objective To use TLDs and radiochromic films to verify the prescribed doses to both planned target volume (PTV) and organ at risk (OAR) and the 2D dose distribution in IMRT. Methods Eight accelerators of different models were selected in Henan province. The polystyrene phantom provided by IAEA was scanned using CT scanners and then the scanned images were transmitted to treatment planning system (TPS) for prescribing respectively the doses to PTV and OAR. IMRT was performed with phantom exposed to a 6 MV X-rays. The irradiated TLDs and films were delivered for measurement and estimation at Secondary Standard Dosimetry Laboratory at National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention. Results According to IAEA requirements, the relative deviations of the TLD-measured and TPS-planned values were within ±7.0% for the prescribed doses to PTV and OAR. The measured results for PTV have shown that the relative deviation of TLD-measured and TPS-planned values were within -0.3% to 6.9% for 8 accelerators, all consistent with the IAEA requirements. For OAR, the relative deviations of TLD-measured and TPS-planned were within -7.0% to 0.3% for 6 accelerators, consistent with the requirements, whereas those for other 2 accelerators were within -10.8% to -8.4%, not up to the requirements. IAEA required that, for 2D dose distribution, the pass rate of 3 mm/3% be ≥90%. The measured values for 7 accelerators were from 90.2% to 99.9%, consistent with the requirements, whereas that for another one was 70.0%, not meeting the requirement. Conclusions The method to verify, using radiochromic film and TLD, the prescribed doses to PTV and OAR and the pass rate of 2D dose distribution is simple and reliable. It is an important step to implement quality control for IMRT and can provide effective support for medical or third-party service institution to verify clinically prescribed dose. Key words: Intensity modulated radiation therapy; Radiochromic film; Planned target volume; Organ at risk; Two-dimensional dose distribution
{"title":"Verification of doses to PTV and OAR and 2D dose distribution in IMRT for 7 accelerators in Sichuan province","authors":"Chunyong Yang, Yuanyuan Zhou, Xingjiang Cao, Xiang Du, S. Luo, Xian Xue, Zhi-jian He, Jin Wang","doi":"10.3760/CMA.J.ISSN.0254-5098.2020.02.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2020.02.010","url":null,"abstract":"Objective \u0000To use TLDs and radiochromic films to verify the prescribed doses to both planned target volume (PTV) and organ at risk (OAR) and the 2D dose distribution in IMRT. \u0000 \u0000 \u0000Methods \u0000Eight accelerators of different models were selected in Henan province. The polystyrene phantom provided by IAEA was scanned using CT scanners and then the scanned images were transmitted to treatment planning system (TPS) for prescribing respectively the doses to PTV and OAR. IMRT was performed with phantom exposed to a 6 MV X-rays. The irradiated TLDs and films were delivered for measurement and estimation at Secondary Standard Dosimetry Laboratory at National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention. \u0000 \u0000 \u0000Results \u0000According to IAEA requirements, the relative deviations of the TLD-measured and TPS-planned values were within ±7.0% for the prescribed doses to PTV and OAR. The measured results for PTV have shown that the relative deviation of TLD-measured and TPS-planned values were within -0.3% to 6.9% for 8 accelerators, all consistent with the IAEA requirements. For OAR, the relative deviations of TLD-measured and TPS-planned were within -7.0% to 0.3% for 6 accelerators, consistent with the requirements, whereas those for other 2 accelerators were within -10.8% to -8.4%, not up to the requirements. IAEA required that, for 2D dose distribution, the pass rate of 3 mm/3% be ≥90%. The measured values for 7 accelerators were from 90.2% to 99.9%, consistent with the requirements, whereas that for another one was 70.0%, not meeting the requirement. \u0000 \u0000 \u0000Conclusions \u0000The method to verify, using radiochromic film and TLD, the prescribed doses to PTV and OAR and the pass rate of 2D dose distribution is simple and reliable. It is an important step to implement quality control for IMRT and can provide effective support for medical or third-party service institution to verify clinically prescribed dose. \u0000 \u0000 \u0000Key words: \u0000Intensity modulated radiation therapy; Radiochromic film; Planned target volume; Organ at risk; Two-dimensional dose distribution","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"201 ","pages":"129-133"},"PeriodicalIF":0.0,"publicationDate":"2020-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72443674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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