Pub Date : 2019-10-25DOI: 10.3760/CMA.J.ISSN.0254-5098.2019.10.008
Bin Wang, Linfeng Gao, Aijun Qian, J. Yao, Jing Sun, Fan Qi
Objective To build a comprehensive information system of radiological health in Shanghai and provide basic data for prevention and control of radiation hazards factors. Methods A management information platform of radiological health suitable for Shanghai was constructed by sorting out the historical archives and records, combining with content of current work, and using the information platform in China for reference. All Institutions are responsible for the collection and input of the data generated in the work, and the system judges the nature of the data according to the rules, and then completes the interactive analysis of the data with the municipal platform according to the standards, which forms the three-level platform management mode of the city, districts and medical institutions. Results Data module platform covering health records, environmental monitoring, business warning and statistical reports was built in one year since its preliminary inception in 2014. In the beginning there were only 468 usersof institutions, and by the end of 2018, about 1 241 users were active. Nearly 300 000 pieces of data were collected. Conclusions The construction of comprehensive management information platform of radiological health in Shanghai promotes the standardization and effectiveness of radiological health information management, provides a monitoring model for sustainable long-term development, and provides basic data for further policy management or decision-making. Key words: Radiological health; Informatization; Survey
{"title":"Construction and application of comprehensive information system of radiological health in Shanghai","authors":"Bin Wang, Linfeng Gao, Aijun Qian, J. Yao, Jing Sun, Fan Qi","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.10.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.10.008","url":null,"abstract":"Objective \u0000To build a comprehensive information system of radiological health in Shanghai and provide basic data for prevention and control of radiation hazards factors. \u0000 \u0000 \u0000Methods \u0000A management information platform of radiological health suitable for Shanghai was constructed by sorting out the historical archives and records, combining with content of current work, and using the information platform in China for reference. All Institutions are responsible for the collection and input of the data generated in the work, and the system judges the nature of the data according to the rules, and then completes the interactive analysis of the data with the municipal platform according to the standards, which forms the three-level platform management mode of the city, districts and medical institutions. \u0000 \u0000 \u0000Results \u0000Data module platform covering health records, environmental monitoring, business warning and statistical reports was built in one year since its preliminary inception in 2014. In the beginning there were only 468 usersof institutions, and by the end of 2018, about 1 241 users were active. Nearly 300 000 pieces of data were collected. \u0000 \u0000 \u0000Conclusions \u0000The construction of comprehensive management information platform of radiological health in Shanghai promotes the standardization and effectiveness of radiological health information management, provides a monitoring model for sustainable long-term development, and provides basic data for further policy management or decision-making. \u0000 \u0000 \u0000Key words: \u0000Radiological health; Informatization; Survey","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"11 1","pages":"756-761"},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84330342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-25DOI: 10.3760/CMA.J.ISSN.0254-5098.2019.09.006
葛迦, Ge Jia, 宁丽华, Ning Lihua, 严森祥, Y. Senxiang, 陆中杰, Luo Zhongjie
Objective To compare the accuracy of two automatic segmentation softwares (Smart Segmentation and MIM Atlas) in organs at risk (OARs) contouring for nasopharyngeal carcinoma (NPC). Methods Totally 55 NPC patients were retrospectively reviewed with manually contoured OARs on CT images, in which 30 cases were randomly selected to create a data base in the Smart Segmentation and MIM Atlas. The remaining 25 cases were automatically contoured with Smart Segmentation and MIM as test cases. The automatic contouring accuracies of two softwares were evaluated with Dice coefficient(DSC), Hausdorff distance(HD), and absolute volume difference(△V) using manual contours as a golden standard. Results The overall DSC, HD and △V of all organs contoured by MIM Atlas and Smart Segmentation were (0.79±0.13) vs. (0.62±0.24) (t=14.06, P<0.05), (5.50±3.84)mm vs.(8.38±4.88)mm (t=-11.40, P<0.05), and (1.52±2.46) cm3vs. (2.38±3.57) cm3 (t=-4.70, P<0.05), respectively. The average DSC of 11 organs (brain stem, optic chiasm, bilateral lens, bilateral optic nerve, bilateral eyeballs, bilateral parotid gland, spinal cord) delineated by MIM Atlas was statistically greater than that of Smart Segmentation (t=5.27, 4.41, 6.34, 5.70, 10.62, 7.45, 3.96, 4.26, 6.25, 5.42, 7.23, P<0.05). The average HD of 10 organs (brain stem, optic chiasm, bilateral lens, bilateral optic nerve, bilateral eyeballs, left parotid gland, spinal cord) delineated by MIM Atlas was statistically less than that of Smart Segmentation (t=-4.51, -4.49, -3.92, -3.45, -5.36, -5.56, -3.89, -3.90, -3.60, -3.68, P<0.05). The average △V of 6 organs (brain stem, optic chiasm, left len, bilateral optic nerve, right eyeball) delineated by MIM Atlas was statistically less than that of Smart Segmentation (t=-2.83, -3.39, -2.56, -2.27, -2.43, -2.51, P<0.05). Conclusions Both softwares have reasonable contouring accuracy for larger organs. The accuracy decreased with the decrease of organ volumes and blurred boundary. Generally, MIM Atlas′s performs better than Smart Segmentation does. Key words: Automatic contouring; Organs-at-risk segmentation; Atlas library; Nasopharyngeal carcinoma
{"title":"Automatic segmentation of organs at risk for nasopharyngeal carcinoma with Smart Segmentation and MIM Atlas","authors":"葛迦, Ge Jia, 宁丽华, Ning Lihua, 严森祥, Y. Senxiang, 陆中杰, Luo Zhongjie","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.09.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.09.006","url":null,"abstract":"Objective \u0000To compare the accuracy of two automatic segmentation softwares (Smart Segmentation and MIM Atlas) in organs at risk (OARs) contouring for nasopharyngeal carcinoma (NPC). \u0000 \u0000 \u0000Methods \u0000Totally 55 NPC patients were retrospectively reviewed with manually contoured OARs on CT images, in which 30 cases were randomly selected to create a data base in the Smart Segmentation and MIM Atlas. The remaining 25 cases were automatically contoured with Smart Segmentation and MIM as test cases. The automatic contouring accuracies of two softwares were evaluated with Dice coefficient(DSC), Hausdorff distance(HD), and absolute volume difference(△V) using manual contours as a golden standard. \u0000 \u0000 \u0000Results \u0000The overall DSC, HD and △V of all organs contoured by MIM Atlas and Smart Segmentation were (0.79±0.13) vs. (0.62±0.24) (t=14.06, P<0.05), (5.50±3.84)mm vs.(8.38±4.88)mm (t=-11.40, P<0.05), and (1.52±2.46) cm3vs. (2.38±3.57) cm3 (t=-4.70, P<0.05), respectively. The average DSC of 11 organs (brain stem, optic chiasm, bilateral lens, bilateral optic nerve, bilateral eyeballs, bilateral parotid gland, spinal cord) delineated by MIM Atlas was statistically greater than that of Smart Segmentation (t=5.27, 4.41, 6.34, 5.70, 10.62, 7.45, 3.96, 4.26, 6.25, 5.42, 7.23, P<0.05). The average HD of 10 organs (brain stem, optic chiasm, bilateral lens, bilateral optic nerve, bilateral eyeballs, left parotid gland, spinal cord) delineated by MIM Atlas was statistically less than that of Smart Segmentation (t=-4.51, -4.49, -3.92, -3.45, -5.36, -5.56, -3.89, -3.90, -3.60, -3.68, P<0.05). The average △V of 6 organs (brain stem, optic chiasm, left len, bilateral optic nerve, right eyeball) delineated by MIM Atlas was statistically less than that of Smart Segmentation (t=-2.83, -3.39, -2.56, -2.27, -2.43, -2.51, P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Both softwares have reasonable contouring accuracy for larger organs. The accuracy decreased with the decrease of organ volumes and blurred boundary. Generally, MIM Atlas′s performs better than Smart Segmentation does. \u0000 \u0000 \u0000Key words: \u0000Automatic contouring; Organs-at-risk segmentation; Atlas library; Nasopharyngeal carcinoma","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"32 1","pages":"668-672"},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87954583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-25DOI: 10.3760/CMA.J.ISSN.0254-5098.2019.09.015
Yinping Tao, Guoping Zhao
Radiotherapy is one of the important methods for treating malignant tumors. However, due to the limitation of normal tissue tolerance dose, it is impossible to give a sufficient irradiation dose to the tumor, which causes treatment failure. Therefore, how to improve the sensitivity of the tumor to radiation is a prominent problem in tumor radiotherapy. Radiosensitizers can enhance the sensitivity of tumor radiotherapy and improve the efficacy of radiotherapy, through accelerating DNA damage, producing free radicals and regulating key molecular targets. This paper summarized the applications of radiosensitizers in radiotherapy, the development status of radiosensitizers and research progresses in the related fields.Furthermore, the possible mechanisms of how radiosensitizers enhance the sensitivity of tumors were also briefly reviewed. This review will elucidate the detailed molecular mechanisms of radiosensitization regulation, promote the development of radiosensitizers, and facilitate the development of new strategies to improve radiotherapy efficiency. Key words: Radiotherapy; Radiosensitizer; Target
{"title":"Application of radiosensitizers in oncotherapy","authors":"Yinping Tao, Guoping Zhao","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.09.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.09.015","url":null,"abstract":"Radiotherapy is one of the important methods for treating malignant tumors. However, due to the limitation of normal tissue tolerance dose, it is impossible to give a sufficient irradiation dose to the tumor, which causes treatment failure. Therefore, how to improve the sensitivity of the tumor to radiation is a prominent problem in tumor radiotherapy. Radiosensitizers can enhance the sensitivity of tumor radiotherapy and improve the efficacy of radiotherapy, through accelerating DNA damage, producing free radicals and regulating key molecular targets. This paper summarized the applications of radiosensitizers in radiotherapy, the development status of radiosensitizers and research progresses in the related fields.Furthermore, the possible mechanisms of how radiosensitizers enhance the sensitivity of tumors were also briefly reviewed. This review will elucidate the detailed molecular mechanisms of radiosensitization regulation, promote the development of radiosensitizers, and facilitate the development of new strategies to improve radiotherapy efficiency. \u0000 \u0000 \u0000Key words: \u0000Radiotherapy; Radiosensitizer; Target","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"47 1","pages":"715-720"},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86914996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-25DOI: 10.3760/CMA.J.ISSN.0254-5098.2019.09.011
俞顺飞, Yu Shunfei, 曹艺耀, Cao Yiyao, 宣志强, Xu Zhiqiang, 章荣华, Zhang Rong-hua, 赖忠俊, Lai Zhongjun, 李新星, L. Xinxing, 赵三虎, Zhao San-hu, 赵尧贤, Zhao Yaoxian, 张庆, Zhang Qing
Objective To investigate the contents of radionuclide 137Cs in seafood from coastal areas of Zhejiang province, and to estimate the annual committed effective dose to population in different regions from ingestion of 137Cs in seafood. Methods Three representative monitoring areas were set on the coastaline of Zhejiang province, and the locally popular seafoods were selected as monitoring objectives. The contents of radionuclide 137Cs were detected using HPGe γ spectrometry. The committed effective doses were estimated based on monitoring results and consumption data on seafoods in Zhejiang. Results The detection ratio of 137Cs in seafood produced on coastal areas of Zhejiang province was estimated to be 35.3% (36/102). Specific activity detected ranged from 0.004 to 0.140 Bq/(kg, Wet). Committed effective doses from ingestion of 137Cs in one year to the population in island region, coastal region and inland region were 3.03×10-5, 1.63×10-5, 3.38×10-6 mSv, respectively, far lower than the world committed effective dose resulting from internal exposure. Conclusions At present, the content level of 137Cs in seafood produced on the coastal areas of Zhejiang province is much lower than the national standard limit, and the dose burden to the population is very minor with no health impact to the population. Key words: Gamma spectrometer; Sea products; 137Cs; Annual committed effective dose
{"title":"Assessment of committed effective dose from ingestion of 137Cs in seafood from coastal areas of Zhejiang province","authors":"俞顺飞, Yu Shunfei, 曹艺耀, Cao Yiyao, 宣志强, Xu Zhiqiang, 章荣华, Zhang Rong-hua, 赖忠俊, Lai Zhongjun, 李新星, L. Xinxing, 赵三虎, Zhao San-hu, 赵尧贤, Zhao Yaoxian, 张庆, Zhang Qing","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.09.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.09.011","url":null,"abstract":"Objective \u0000To investigate the contents of radionuclide 137Cs in seafood from coastal areas of Zhejiang province, and to estimate the annual committed effective dose to population in different regions from ingestion of 137Cs in seafood. \u0000 \u0000 \u0000Methods \u0000Three representative monitoring areas were set on the coastaline of Zhejiang province, and the locally popular seafoods were selected as monitoring objectives. The contents of radionuclide 137Cs were detected using HPGe γ spectrometry. The committed effective doses were estimated based on monitoring results and consumption data on seafoods in Zhejiang. \u0000 \u0000 \u0000Results \u0000The detection ratio of 137Cs in seafood produced on coastal areas of Zhejiang province was estimated to be 35.3% (36/102). Specific activity detected ranged from 0.004 to 0.140 Bq/(kg, Wet). Committed effective doses from ingestion of 137Cs in one year to the population in island region, coastal region and inland region were 3.03×10-5, 1.63×10-5, 3.38×10-6 mSv, respectively, far lower than the world committed effective dose resulting from internal exposure. \u0000 \u0000 \u0000Conclusions \u0000At present, the content level of 137Cs in seafood produced on the coastal areas of Zhejiang province is much lower than the national standard limit, and the dose burden to the population is very minor with no health impact to the population. \u0000 \u0000 \u0000Key words: \u0000Gamma spectrometer; Sea products; 137Cs; Annual committed effective dose","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"5 1","pages":"697-701"},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75890459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-25DOI: 10.3760/CMA.J.ISSN.0254-5098.2019.09.005
Yanru Feng, Luying Liu
Objective To evaluate whether any association exists between peripheral blood cell-based inflammatory biomarkers obtained before adjuvant chemoradiotherapy and adverse events (AEs) and survival of patients with pathological stage Ⅱ/Ⅲ rectal cancer treated by adjuvant chemoradiotherapy. Methods A total of 109 rectal cancer patients were included. The prognostic abilities of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR) and neutrophil to albumin ratio (NAR) for overall survival (OS) were calculated by the receiver operating characteristic (ROC) curves. Results NAR was associated with the occurrence of grade ≥2 leukopenia (OR=4.442, 95% CI: 1.216-16.221, P 0.05). The 5-year disease-free survival (DFS) rates of patients with NAR ≥ 0.055 and patients with NAR<0.055 were 59.1% and 76.8%, respectively (χ2=3.887, P<0.05). Multivariate analysis by Cox proportional-hazards model showed that NAR was significantly associated with OS (HR=3.035, 95% CI: 1.021-9.019, P<0.05). Conclusions These results suggest that NAR obtained before adjuvant chemoradiotherapy might serve as an independent biomarker for predicting AEs and prognosis in rectal cancer treated with adjuvant chemoradiotherapy. Key words: Rectal cancer; Neutrophil to albumin ratio; Chemoradiotherapy; Acute adverse event; Survival
{"title":"Associations of neutrophil to albumin ratio with acute adverse events and survival in patients with pathological stage II/III rectal cancer receiving adjuvant chemoradiotherapy","authors":"Yanru Feng, Luying Liu","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.09.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.09.005","url":null,"abstract":"Objective \u0000To evaluate whether any association exists between peripheral blood cell-based inflammatory biomarkers obtained before adjuvant chemoradiotherapy and adverse events (AEs) and survival of patients with pathological stage Ⅱ/Ⅲ rectal cancer treated by adjuvant chemoradiotherapy. \u0000 \u0000 \u0000Methods \u0000A total of 109 rectal cancer patients were included. The prognostic abilities of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR) and neutrophil to albumin ratio (NAR) for overall survival (OS) were calculated by the receiver operating characteristic (ROC) curves. \u0000 \u0000 \u0000Results \u0000NAR was associated with the occurrence of grade ≥2 leukopenia (OR=4.442, 95% CI: 1.216-16.221, P 0.05). The 5-year disease-free survival (DFS) rates of patients with NAR ≥ 0.055 and patients with NAR<0.055 were 59.1% and 76.8%, respectively (χ2=3.887, P<0.05). Multivariate analysis by Cox proportional-hazards model showed that NAR was significantly associated with OS (HR=3.035, 95% CI: 1.021-9.019, P<0.05). \u0000 \u0000 \u0000Conclusions \u0000These results suggest that NAR obtained before adjuvant chemoradiotherapy might serve as an independent biomarker for predicting AEs and prognosis in rectal cancer treated with adjuvant chemoradiotherapy. \u0000 \u0000 \u0000Key words: \u0000Rectal cancer; Neutrophil to albumin ratio; Chemoradiotherapy; Acute adverse event; Survival","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"1 1","pages":"663-667"},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89696826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To investigate the effect of iron shield at different depths within main protection wall on the dose rate outside the protection wall. Methods By adopting the FLUKA code, a therapeutic room model was constructed with its primary protective barrier consisting of concrete and iron. In order to obtain its ambient dose equivalent rate distribution, the 250 MeV protons and 220 MeV protons impinging on water phantom were simulated separately. Results With varying depth of iron plate embedded in barrier, the ambient dose equivalent rates in the two simulated conditions differed sinificantly at 30 cm outside the protection wall. The maximum ambient dose equivalent rate(220 MeV: 3.42 μSv/h, 250 MeV: 6.39 μSv/h) was more than 2 times higher than the minimum ambient dose equivalent rate(220 MeV: 1.75 μSv/h, 250 MeV: 3.32 μSv/h). Conclusions In the design of therapeutic proton accelerator, it is essential to evaluate carefully the location where the iron shield is in main protection wall. Key words: Monte Carlo simulation; Therapeutic proton accelerator; Barrier; Ambient dose equivalent rate
{"title":"Study on the optimization of radiation protection for therapeutic proton synchrotron","authors":"Weiguo Zhu, Jing Liang, Chang-song Hou, Dexing Lian, Zhen Zhang","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.09.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.09.013","url":null,"abstract":"Objective \u0000To investigate the effect of iron shield at different depths within main protection wall on the dose rate outside the protection wall. \u0000 \u0000 \u0000Methods \u0000By adopting the FLUKA code, a therapeutic room model was constructed with its primary protective barrier consisting of concrete and iron. In order to obtain its ambient dose equivalent rate distribution, the 250 MeV protons and 220 MeV protons impinging on water phantom were simulated separately. \u0000 \u0000 \u0000Results \u0000With varying depth of iron plate embedded in barrier, the ambient dose equivalent rates in the two simulated conditions differed sinificantly at 30 cm outside the protection wall. The maximum ambient dose equivalent rate(220 MeV: 3.42 μSv/h, 250 MeV: 6.39 μSv/h) was more than 2 times higher than the minimum ambient dose equivalent rate(220 MeV: 1.75 μSv/h, 250 MeV: 3.32 μSv/h). \u0000 \u0000 \u0000Conclusions \u0000In the design of therapeutic proton accelerator, it is essential to evaluate carefully the location where the iron shield is in main protection wall. \u0000 \u0000 \u0000Key words: \u0000Monte Carlo simulation; Therapeutic proton accelerator; Barrier; Ambient dose equivalent rate","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"271 1","pages":"707-710"},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77039673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-25DOI: 10.3760/CMA.J.ISSN.0254-5098.2019.09.008
Xile Zhang, R. Yang, Jun Li, Daojian An, Jiaqi Li, Junjie Wang
Objective To analyze the patient-specific dosimetric verification result of stereotactic body radiotherapy (SBRT) plans, and to investigate the sensitivity of the result to three factors: interpolation of measured data, size of dose calculation grid and assessment threshold. Methods The dosimetric verification results of SBRT plans of 50 patients were retrospectively analyzed to evaluate the impact of the following factors. The linear interpolation (1.00 mm) and non-interpolation (7.62 mm) were applied to measured data respectively. Three dose calculation grid sizes of Eclipse planning system, i. e., 1.0 mm, 2.5 mm and 4.0 mm were compared respectively. The threshold of dose assessment was selected as 10%, 20% and 30%, respectively. Three criteria of γ analysis were selected: 2%/2 mm, 3%/2 mm and 3%/3 mm. Results Under criteria of 2%/2 mm, 3%/2 mm and 3%/3 mm, the average γ passing rates were (86.3±7.3)% and (93.7±5.6)%, (94.1±4.4)% and(97.7±3.9)%, (97.7 ±2.2)% and (99.1±1.7)%, respectively, with and without linear interpolation. Relative to the 1.0 mm reference grid, the grids of 2.5 mm and 4.0 mm significantly decreased γ passing rates by 3.8%, 1.9%, 0.8% (t=8.41, 9.06, 5.30, P<0.05) and by 6.5%, 6.0%, 3.5% (t=-13.76, -13.15, -9.80, P<0.05) under criteria of 2%/2 mm, 3%/2 mm and 3%/3 mm, respectively. Relative to the 10% reference threshold, the shresholds of 20% and 30% significantly decreased γ passing rates by 2.4%, 1.0%, 0.6%(t=-8.60, -5.86, -4.68, P<0.05) and by 4.0%, 1.7%, 0.9% (t=-9.45, -6.66, -5.06, P<0.05) under criteria of 2%/2 mm, 3%/2 mm and 3%/3 mm, respectively. Conclusions Interpolation, dose calculation grid size and dose assessment threshold are influential factors of dose verification result, and need to be considered during dosimetric verification of stereotactic radiotherapy patients. Key words: Stereotactic body radiotherapy; Dosimetric verification; Interpolation; Dose calculation grid size; Dose assessment threshold
{"title":"Analysis of dosimetric verification results of stereotactic body radiotherapy","authors":"Xile Zhang, R. Yang, Jun Li, Daojian An, Jiaqi Li, Junjie Wang","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.09.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.09.008","url":null,"abstract":"Objective \u0000To analyze the patient-specific dosimetric verification result of stereotactic body radiotherapy (SBRT) plans, and to investigate the sensitivity of the result to three factors: interpolation of measured data, size of dose calculation grid and assessment threshold. \u0000 \u0000 \u0000Methods \u0000The dosimetric verification results of SBRT plans of 50 patients were retrospectively analyzed to evaluate the impact of the following factors. The linear interpolation (1.00 mm) and non-interpolation (7.62 mm) were applied to measured data respectively. Three dose calculation grid sizes of Eclipse planning system, i. e., 1.0 mm, 2.5 mm and 4.0 mm were compared respectively. The threshold of dose assessment was selected as 10%, 20% and 30%, respectively. Three criteria of γ analysis were selected: 2%/2 mm, 3%/2 mm and 3%/3 mm. \u0000 \u0000 \u0000Results \u0000Under criteria of 2%/2 mm, 3%/2 mm and 3%/3 mm, the average γ passing rates were (86.3±7.3)% and (93.7±5.6)%, (94.1±4.4)% and(97.7±3.9)%, (97.7 ±2.2)% and (99.1±1.7)%, respectively, with and without linear interpolation. Relative to the 1.0 mm reference grid, the grids of 2.5 mm and 4.0 mm significantly decreased γ passing rates by 3.8%, 1.9%, 0.8% (t=8.41, 9.06, 5.30, P<0.05) and by 6.5%, 6.0%, 3.5% (t=-13.76, -13.15, -9.80, P<0.05) under criteria of 2%/2 mm, 3%/2 mm and 3%/3 mm, respectively. Relative to the 10% reference threshold, the shresholds of 20% and 30% significantly decreased γ passing rates by 2.4%, 1.0%, 0.6%(t=-8.60, -5.86, -4.68, P<0.05) and by 4.0%, 1.7%, 0.9% (t=-9.45, -6.66, -5.06, P<0.05) under criteria of 2%/2 mm, 3%/2 mm and 3%/3 mm, respectively. \u0000 \u0000 \u0000Conclusions \u0000Interpolation, dose calculation grid size and dose assessment threshold are influential factors of dose verification result, and need to be considered during dosimetric verification of stereotactic radiotherapy patients. \u0000 \u0000 \u0000Key words: \u0000Stereotactic body radiotherapy; Dosimetric verification; Interpolation; Dose calculation grid size; Dose assessment threshold","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"13 1","pages":"680-685"},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73318295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-25DOI: 10.3760/CMA.J.ISSN.0254-5098.2019.09.014
Junna Wang, Shiwei Wang, Zhichao Xu, Dongya Ling
Objective To investigate the application value of CTDIvol and size-specific dose estimate(SSDE) in evaluating the radiation dose of adult chest CT. Methods A retrospective analysis was made on the CTDIvoland SSDE of 128 patients who underwent chest CT scanning in the First Affiliated Hospital of Zhejiang Chinese Medical University from March to April 2017 and all images are adequate for diagnosis. The subjects were divided into three groups according to body mass index (BMI): Group A, 38 cases with 16≤BMI<21.1 kg/m2; Group B, 53 cases with 21.1≤BMI<23.9 kg/m2; Group C, 37 cases with 23.9≤BMI<34.1 kg/m2. The diameters of anterior-posterior (AP) and left-right (LAT) of each patient were measured in the slice of nipple level, and CTDIvol, effective diameter (ED), conversion factor (fsize) and SSDE of each patient were recorded and calculated. Meanwhile, the differences between CTDIvol and SSDE in different BMI groups were compared. Results SSDE of each group was higher than CTDIvol, and increased by 50.13%, 42.83% and 33.68% in group A, B and C, respectively. There were significant differences in radiation dose between CTDIvol and SSDE in the three groups (t=-48.873, -57.001, -32.651, P<0.05). There were significant differences in ED, fsize, CTDIvol and SSDE among the three groups (F=51.456, 47.749, 113.916, 106.449, P<0.05). Conclusions SSDE can evaluate the radiation dose absorbed by patients with different body types in chest CT, while CTDIvol underestimated the radiation dose.The lower BMI, the greater the underestimated dose value, the more radiation dose absorbed. Key words: Radiation dose; Chest; CT; Size-specific dose estimate
{"title":"Application value of the two estimation methods in evaluating the radiation dose of adult chest CT","authors":"Junna Wang, Shiwei Wang, Zhichao Xu, Dongya Ling","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.09.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.09.014","url":null,"abstract":"Objective \u0000To investigate the application value of CTDIvol and size-specific dose estimate(SSDE) in evaluating the radiation dose of adult chest CT. \u0000 \u0000 \u0000Methods \u0000A retrospective analysis was made on the CTDIvoland SSDE of 128 patients who underwent chest CT scanning in the First Affiliated Hospital of Zhejiang Chinese Medical University from March to April 2017 and all images are adequate for diagnosis. The subjects were divided into three groups according to body mass index (BMI): Group A, 38 cases with 16≤BMI<21.1 kg/m2; Group B, 53 cases with 21.1≤BMI<23.9 kg/m2; Group C, 37 cases with 23.9≤BMI<34.1 kg/m2. The diameters of anterior-posterior (AP) and left-right (LAT) of each patient were measured in the slice of nipple level, and CTDIvol, effective diameter (ED), conversion factor (fsize) and SSDE of each patient were recorded and calculated. Meanwhile, the differences between CTDIvol and SSDE in different BMI groups were compared. \u0000 \u0000 \u0000Results \u0000SSDE of each group was higher than CTDIvol, and increased by 50.13%, 42.83% and 33.68% in group A, B and C, respectively. There were significant differences in radiation dose between CTDIvol and SSDE in the three groups (t=-48.873, -57.001, -32.651, P<0.05). There were significant differences in ED, fsize, CTDIvol and SSDE among the three groups (F=51.456, 47.749, 113.916, 106.449, P<0.05). \u0000 \u0000 \u0000Conclusions \u0000SSDE can evaluate the radiation dose absorbed by patients with different body types in chest CT, while CTDIvol underestimated the radiation dose.The lower BMI, the greater the underestimated dose value, the more radiation dose absorbed. \u0000 \u0000 \u0000Key words: \u0000Radiation dose; Chest; CT; Size-specific dose estimate","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"217 1","pages":"711-714"},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85644227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-25DOI: 10.3760/CMA.J.ISSN.0254-5098.2019.09.007
S. Ding, Jian-Bin Hu, Jun Zhang, H. Gu, Yixuan Wang, Yi-mei Liu
Objective To investigate IMRT planning process using the combined application of failure modes and effects analysis (FMEA) and fault tree analysis (FTA) by reference to the report of Task Group 100 of the AAPM, and stablish and optimize the quality. Methods A multidisciplinary team detailed the process mapping of IMRT planning using Eclipse TPS. The team evaluated the potential failure modes (FMs) of every process step. The evaluation was divided into two groups according to whether quality management (QM) was considered. For every FM, occurrence (O), severity (S) and detectability (D) by consensus were evaluated, and the product of O, S and D yielded the risk priority number (RPN), which permitted the ranking of the FMs. Finally, FTA was used to determine the root factors contributing to the riskiest failure modes. Results The IMRT plan process consisted of 10 major sub-processes and 33 steps, which amounted to 47 failure modes. For the group without quality management, the RPN of FMs was between 13.2-271.8, 27 of which had RPN≥80, and 18 FMs had S≥8. For the group with quality management, the RPN of FMs was between 11.2-158.4, 11 of which had RPN≥80. The difference of RPN between the two groups was statistically significant (RPN of the group without QM=101.17±66.34, RPN of the group with QM=59.54±35.64, t=8.501, P<0.05). Finally, FTA was used to determine the root factors contributing to the FMs, i. e., prescription dose definition and importing images. Conclusions The FMEA and FTA methods are operable and practical, which can systematically and comprehensively analyze the potential failures and risks existing in the process of IMRT plan. And the FMEA and FTA can contribute to establish and optimize the quality management program in radiotherapy. Key words: Intensity modulated radiotherapy; Failure modes and effects analysis; Failure tree analysis; Quality management
{"title":"Application of failure mode and effects analysis and fault tree analysis to IMRT planning","authors":"S. Ding, Jian-Bin Hu, Jun Zhang, H. Gu, Yixuan Wang, Yi-mei Liu","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.09.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.09.007","url":null,"abstract":"Objective \u0000To investigate IMRT planning process using the combined application of failure modes and effects analysis (FMEA) and fault tree analysis (FTA) by reference to the report of Task Group 100 of the AAPM, and stablish and optimize the quality. \u0000 \u0000 \u0000Methods \u0000A multidisciplinary team detailed the process mapping of IMRT planning using Eclipse TPS. The team evaluated the potential failure modes (FMs) of every process step. The evaluation was divided into two groups according to whether quality management (QM) was considered. For every FM, occurrence (O), severity (S) and detectability (D) by consensus were evaluated, and the product of O, S and D yielded the risk priority number (RPN), which permitted the ranking of the FMs. Finally, FTA was used to determine the root factors contributing to the riskiest failure modes. \u0000 \u0000 \u0000Results \u0000The IMRT plan process consisted of 10 major sub-processes and 33 steps, which amounted to 47 failure modes. For the group without quality management, the RPN of FMs was between 13.2-271.8, 27 of which had RPN≥80, and 18 FMs had S≥8. For the group with quality management, the RPN of FMs was between 11.2-158.4, 11 of which had RPN≥80. The difference of RPN between the two groups was statistically significant (RPN of the group without QM=101.17±66.34, RPN of the group with QM=59.54±35.64, t=8.501, P<0.05). Finally, FTA was used to determine the root factors contributing to the FMs, i. e., prescription dose definition and importing images. \u0000 \u0000 \u0000Conclusions \u0000The FMEA and FTA methods are operable and practical, which can systematically and comprehensively analyze the potential failures and risks existing in the process of IMRT plan. And the FMEA and FTA can contribute to establish and optimize the quality management program in radiotherapy. \u0000 \u0000 \u0000Key words: \u0000Intensity modulated radiotherapy; Failure modes and effects analysis; Failure tree analysis; Quality management","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"23 1","pages":"673-679"},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79733631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-25DOI: 10.3760/CMA.J.ISSN.0254-5098.2019.09.004
Haiyang Wang, Y. Pi
Objective To investigate the dosimetric differences between TomoDirect (TD) and Helical Tomotherapy (HT) in total body irradiation (TBI), as well to evaluate the plan quality and delivery efficiency of TD. Methods Eight patients with acute leukemia at an average height of about 120 cm who had undergone TBI in the first affiliated hospital of Zhengzhou university were retrospectively reviewed and replanned with the TD and HT techniques for dosimetric comparison. Identical planning parameters were configured for both techniques except that TD plans were designed with 2-12 equally spaced odd number fields and with an initial angle of 180 or 0 degree. Dosimetric differences in mean dose of plan target volume (PTVDmean), homogeneity index (HI), dose of organs at risk (OARs), as well as delivery time were compared between the TD and HT plans. Results The TD plans with 9 fields or more had similar PTVDmeanand HI compared with HT plans, while TD plans with less than 9 fields had a significant different PTVDmean(t=-3.12, -5.41, -20.33, -4.56, -7.22, -11.27, P<0.05) and HI (t=-2.94, -5.18, -15.66, -4.31, -5.51, - 9.13, P<0.05) compared with those of HT. In terms of OARs, the TD plans with 7 fields or more had no significant dosimetric differences in the mean dose of left and right lung compared with the HT plans. The TD plans with 3 fields had significant different maximum dose in the left lens plan risk volume(PRV) (2.14±0.60) Gy and the right lens PRV (3.05±0.10) Gy (t=0.77, 0.63, P<0.05) compared with the HT plans. No significant difference in delivery time was observed. The initial angle of the TD plans had no effects on PTVDmean, HI, OAR dosimetry and delivery time. Conclusions The TD plans with 9 fields or more can achieve similar plan quality in terms of target coverage, OAR sparing and delivery time, but have an advantage in the maximum dose to lens PRV compared with the HT plans. Key words: Total body irradiation; TomoDirect; Helical tomotherapy
{"title":"Dosimetric comparison between TomoDirect and Helical Tomotherapy in total body irradiation","authors":"Haiyang Wang, Y. Pi","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.09.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.09.004","url":null,"abstract":"Objective \u0000To investigate the dosimetric differences between TomoDirect (TD) and Helical Tomotherapy (HT) in total body irradiation (TBI), as well to evaluate the plan quality and delivery efficiency of TD. \u0000 \u0000 \u0000Methods \u0000Eight patients with acute leukemia at an average height of about 120 cm who had undergone TBI in the first affiliated hospital of Zhengzhou university were retrospectively reviewed and replanned with the TD and HT techniques for dosimetric comparison. Identical planning parameters were configured for both techniques except that TD plans were designed with 2-12 equally spaced odd number fields and with an initial angle of 180 or 0 degree. Dosimetric differences in mean dose of plan target volume (PTVDmean), homogeneity index (HI), dose of organs at risk (OARs), as well as delivery time were compared between the TD and HT plans. \u0000 \u0000 \u0000Results \u0000The TD plans with 9 fields or more had similar PTVDmeanand HI compared with HT plans, while TD plans with less than 9 fields had a significant different PTVDmean(t=-3.12, -5.41, -20.33, -4.56, -7.22, -11.27, P<0.05) and HI (t=-2.94, -5.18, -15.66, -4.31, -5.51, - 9.13, P<0.05) compared with those of HT. In terms of OARs, the TD plans with 7 fields or more had no significant dosimetric differences in the mean dose of left and right lung compared with the HT plans. The TD plans with 3 fields had significant different maximum dose in the left lens plan risk volume(PRV) (2.14±0.60) Gy and the right lens PRV (3.05±0.10) Gy (t=0.77, 0.63, P<0.05) compared with the HT plans. No significant difference in delivery time was observed. The initial angle of the TD plans had no effects on PTVDmean, HI, OAR dosimetry and delivery time. \u0000 \u0000 \u0000Conclusions \u0000The TD plans with 9 fields or more can achieve similar plan quality in terms of target coverage, OAR sparing and delivery time, but have an advantage in the maximum dose to lens PRV compared with the HT plans. \u0000 \u0000 \u0000Key words: \u0000Total body irradiation; TomoDirect; Helical tomotherapy","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"79 1","pages":"658-662"},"PeriodicalIF":0.0,"publicationDate":"2019-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86456482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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