Pub Date : 2019-12-25DOI: 10.3760/CMA.J.ISSN.0254-5098.2019.12.014
Weiguo Zhang, Jiaping Liu, X. Jia, T. Jiang
Objective To explore the possibility that the neck extension in chest CT scanning would make thyroid move upward and reduce thyroid radiation exposure. Methods The images of 1 994 patients who underwent chest CT examination in Beijing Chaoyang Hospital from March to June in 2017 were compared and analyzed retrospectively. According to different cervical positions, patients were divided into extension group and routine group with 997 cases in each group. In the extension group, the head and neck bended back to the maxillary top position while in the regular group with normal position. The length of thyroid glands exposed to the scanning range and the number of cases of all glands moved out of the scanning range were observed with the first rib head as the baseline counting mark. The differences in exposed length of thyroid gland in primary radiation area between the two groups were compared. Results The length of exposed thyroid gland by primary radiation in the extension group (4.69±5.68) mm was significantly shorter (U=91 073.5, P<0.05) than that in the routine group (17.16±6.68) mm. In addition, the number of thyroid glands out of scanning range completely in the extension group (n=519, with ratio of 52.1%) was significantly more (U=594.8, P<0.05) than those in the routine group (n=32, with ratio of 3.2%). Conclusions During chest CT scan, the length of thyroid gland in the scanning field can be shortened with neck backbend position and the radioation protection for thyroid gland can be effectively improved. Key words: Computed tomography(CT); Neck position; Thyroid; Radiation dose
{"title":"Evaluation of the value of neck extension in chest CT scanning","authors":"Weiguo Zhang, Jiaping Liu, X. Jia, T. Jiang","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.12.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.12.014","url":null,"abstract":"Objective \u0000To explore the possibility that the neck extension in chest CT scanning would make thyroid move upward and reduce thyroid radiation exposure. \u0000 \u0000 \u0000Methods \u0000The images of 1 994 patients who underwent chest CT examination in Beijing Chaoyang Hospital from March to June in 2017 were compared and analyzed retrospectively. According to different cervical positions, patients were divided into extension group and routine group with 997 cases in each group. In the extension group, the head and neck bended back to the maxillary top position while in the regular group with normal position. The length of thyroid glands exposed to the scanning range and the number of cases of all glands moved out of the scanning range were observed with the first rib head as the baseline counting mark. The differences in exposed length of thyroid gland in primary radiation area between the two groups were compared. \u0000 \u0000 \u0000Results \u0000The length of exposed thyroid gland by primary radiation in the extension group (4.69±5.68) mm was significantly shorter (U=91 073.5, P<0.05) than that in the routine group (17.16±6.68) mm. In addition, the number of thyroid glands out of scanning range completely in the extension group (n=519, with ratio of 52.1%) was significantly more (U=594.8, P<0.05) than those in the routine group (n=32, with ratio of 3.2%). \u0000 \u0000 \u0000Conclusions \u0000During chest CT scan, the length of thyroid gland in the scanning field can be shortened with neck backbend position and the radioation protection for thyroid gland can be effectively improved. \u0000 \u0000 \u0000Key words: \u0000Computed tomography(CT); Neck position; Thyroid; Radiation dose","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"16 1","pages":"951-954"},"PeriodicalIF":0.0,"publicationDate":"2019-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74630814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-25DOI: 10.3760/CMA.J.ISSN.0254-5098.2019.12.006
S. Ming, Y. Yong, G. Guanzhong, Ren Jianxin, Yao Xinsen, Qiu Xiao-ping
Objective To investigate the changes of accumulated dose in target area and organs at risk (OARs) for radiotherapy of left breast cancer by deformable and rigid image registration. Methods A total of 16 left breast cancer patients treated with 6 MV X-ray IMRT were analyzed retrospectively. All targets included the lymph node drainage area and the chest wall. All patients underwent simulation of the primary positioning and repositioning to obtain CT images. Primary and secondary treatment plans were developed using primary positioning CT (CT1) and repositioning CT (CT2), denoted as Plan1 and Plan2 respectively. The dose distribution of Plan2 was mapped to CT1 with rigid and deformable registration from CT2 to CT1 and then added to the dose distribution of Plan1 to obtain Plan-rigid and Plan-deform, respectively. The dosimetric differences between targets and the OARs of the four plans were compared. Results The CTV volume on CT2 was reduced by 6.64% from that on CT1. The homogeneity index (HI) increased by 23.05% after deformation-based accumulation. The Dice similarity coefficients (DSCs) of the heart, left lung and right lung were lower than those before deformable registration (0.94±0.01 vs. 0.89±0.05, 0.96±0.01 vs. 0.91±0.03, and 0.96±0.01 vs. 0.92±0.03, respectively), and the differences were statistically significant (Z=-3.208, -3.533, -3.535, P 0.05), while the dose-volume indices in Plan-rigid were higher than that in Plan-deform. Conclusions Rigid registration is recommended in patients undergoing radical resection of left breast cancer with little change in the volume and dose-volume index of the target area and organs at risk. The dose-volume index of the initial intensity modulation plan can basically reflect the dose-volume statistics of both lungs and heart. Key words: Breast cancer; Dose addition; Deformation registration; Dose assessment; IMRT
目的探讨形变和刚性图像配准对左乳腺癌放疗靶区和危险器官累积剂量的影响。方法回顾性分析16例接受6mv x线放射治疗的左乳腺癌患者的临床资料。所有目标包括淋巴结引流区和胸壁。所有患者都进行了初始定位和重新定位的模拟，以获得CT图像。采用初定位CT (CT1)和重定位CT (CT2)制定一级和二级治疗方案，分别记为Plan1和Plan2。将Plan2的剂量分布映射到CT1，从CT2到CT1进行刚性配准和变形配准，然后与Plan1的剂量分布相加，分别得到Plan-rigid和Plan-deform。比较了四种方案靶区和桨区剂量学差异。结果CT2的CTV体积较CT1缩小6.64%。变形积累后均匀性指数(HI)提高23.05%。心、左、右肺的Dice相似系数(dsc)均低于变形配准前(分别为0.94±0.01 vs. 0.89±0.05、0.96±0.01 vs. 0.91±0.03、0.96±0.01 vs. 0.92±0.03)，差异均有统计学意义(Z=-3.208、-3.533、-3.535,P 0.05)，而Plan-rigid组的剂量-体积指标高于Plan-deform组。结论左侧乳腺癌根治术患者在靶区和危险器官的体积、剂量-体积指数变化不大的情况下，推荐采用刚性登记。初始强度调节方案的剂量-体积指数基本能反映肺和心脏的剂量-体积统计。关键词:乳腺癌;剂量增加;变形登记;剂量的评估;放射
{"title":"Study on dose accumulation in IMRT for left breast cancer patients after radical mastectomy","authors":"S. Ming, Y. Yong, G. Guanzhong, Ren Jianxin, Yao Xinsen, Qiu Xiao-ping","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.12.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.12.006","url":null,"abstract":"Objective \u0000To investigate the changes of accumulated dose in target area and organs at risk (OARs) for radiotherapy of left breast cancer by deformable and rigid image registration. \u0000 \u0000 \u0000Methods \u0000A total of 16 left breast cancer patients treated with 6 MV X-ray IMRT were analyzed retrospectively. All targets included the lymph node drainage area and the chest wall. All patients underwent simulation of the primary positioning and repositioning to obtain CT images. Primary and secondary treatment plans were developed using primary positioning CT (CT1) and repositioning CT (CT2), denoted as Plan1 and Plan2 respectively. The dose distribution of Plan2 was mapped to CT1 with rigid and deformable registration from CT2 to CT1 and then added to the dose distribution of Plan1 to obtain Plan-rigid and Plan-deform, respectively. The dosimetric differences between targets and the OARs of the four plans were compared. \u0000 \u0000 \u0000Results \u0000The CTV volume on CT2 was reduced by 6.64% from that on CT1. The homogeneity index (HI) increased by 23.05% after deformation-based accumulation. The Dice similarity coefficients (DSCs) of the heart, left lung and right lung were lower than those before deformable registration (0.94±0.01 vs. 0.89±0.05, 0.96±0.01 vs. 0.91±0.03, and 0.96±0.01 vs. 0.92±0.03, respectively), and the differences were statistically significant (Z=-3.208, -3.533, -3.535, P 0.05), while the dose-volume indices in Plan-rigid were higher than that in Plan-deform. \u0000 \u0000 \u0000Conclusions \u0000Rigid registration is recommended in patients undergoing radical resection of left breast cancer with little change in the volume and dose-volume index of the target area and organs at risk. The dose-volume index of the initial intensity modulation plan can basically reflect the dose-volume statistics of both lungs and heart. \u0000 \u0000 \u0000Key words: \u0000Breast cancer; Dose addition; Deformation registration; Dose assessment; IMRT","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"2 1","pages":"910-915"},"PeriodicalIF":0.0,"publicationDate":"2019-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83766026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-25DOI: 10.3760/CMA.J.ISSN.0254-5098.2019.12.010
郑琪珊, Zheng Qishan, 张燕, Zhang Yan, 黄丽华, H. Lihua, 郑森兴, Zheng Senxing, 赵时敏, Zhao Shimin, 刘佳, Liu Jia, 王德男, Wang Denan, 刘晰予, L. Xiyu
Objective To investigate the 90Sr concentration levels in the monitoring areas and the control area at Ningde Nuclear Power Plant (NPP). Methods Food samples were collected from the monitoring areas in 30 km of Ningde NPP and the control area far away. The radioactive levels of 90Sr in food samples were analyzed using the chromatography with 2-(2-ethylhexyl) phosphate fast extraction method. Results In this survey, 90Sr radioactive concentrations in 30 varieties of foods in 6 categories were analyzed. In the monitoring area, 90Sr radioactivity concentration in the samples collected were in the range of 0.017-1.830 Bq/kg for cereals, beans and potatoes, 0.021-0.318 Bq/kg for vegetables, 0.007-7.690 Bq/kg for quatic products, and 0.009-0.184 Bq/kg for meats; whereas, in the control area, cereals, beans and potatoes in 0.017-0.700 Bq/kg, vegetables in 0.034-0.677 Bq/kg, aquatic products in 0.038-3.360 Bq/kg, and meats in 0.019-0.054 Bq/kg. Conclusions The 90Sr radioactive concentrations in foods were far below the food standard limits in this survey. The contribution of evaluated to the public from the 90Sr in foods was neglectable. Key words: Nuclear power plant; Food; Radioactive levels; 90Sr
{"title":"Investigation on 90Sr concentrations in foods near Ningde Nuclear Power Plant in 2013-2017","authors":"郑琪珊, Zheng Qishan, 张燕, Zhang Yan, 黄丽华, H. Lihua, 郑森兴, Zheng Senxing, 赵时敏, Zhao Shimin, 刘佳, Liu Jia, 王德男, Wang Denan, 刘晰予, L. Xiyu","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.12.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.12.010","url":null,"abstract":"Objective \u0000To investigate the 90Sr concentration levels in the monitoring areas and the control area at Ningde Nuclear Power Plant (NPP). \u0000 \u0000 \u0000Methods \u0000Food samples were collected from the monitoring areas in 30 km of Ningde NPP and the control area far away. The radioactive levels of 90Sr in food samples were analyzed using the chromatography with 2-(2-ethylhexyl) phosphate fast extraction method. \u0000 \u0000 \u0000Results \u0000In this survey, 90Sr radioactive concentrations in 30 varieties of foods in 6 categories were analyzed. In the monitoring area, 90Sr radioactivity concentration in the samples collected were in the range of 0.017-1.830 Bq/kg for cereals, beans and potatoes, 0.021-0.318 Bq/kg for vegetables, 0.007-7.690 Bq/kg for quatic products, and 0.009-0.184 Bq/kg for meats; whereas, in the control area, cereals, beans and potatoes in 0.017-0.700 Bq/kg, vegetables in 0.034-0.677 Bq/kg, aquatic products in 0.038-3.360 Bq/kg, and meats in 0.019-0.054 Bq/kg. \u0000 \u0000 \u0000Conclusions \u0000The 90Sr radioactive concentrations in foods were far below the food standard limits in this survey. The contribution of evaluated to the public from the 90Sr in foods was neglectable. \u0000 \u0000 \u0000Key words: \u0000Nuclear power plant; Food; Radioactive levels; 90Sr","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"11 1","pages":"931-935"},"PeriodicalIF":0.0,"publicationDate":"2019-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88741712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-25DOI: 10.3760/CMA.J.ISSN.0254-5098.2019.12.002
Yongsheng Wang, Mingming Wang
Objective To study the expression of neuronal migration-related factors and spatial learning and memory of rats exposed to tritiated water (HTO). Methods Hippocampal neural cells from newborn Sprague-Dawley(SD) rats at postnatal 24 h were primarily cultured in DMEM/F12 medium with 20% of fetal bovine serum for 6 days, followed by subjection to tritiated water(HTO) at concentrations of 3.7×102, 3.7×103, 3.7×104, 3.7×105, 3.7×106 Bq/ml for 24 h, respectively. Western blot and RT-qPCR were used to determine the expression levels of F-actin, α-tubulin, tau, AP2, BDNF mRNA and Reelin mRNA. 16 pregnant SD rats at embryonic (E) day 14 were randomly divided into the tested and control groups (8 rats/ each group). The tested rats were injected with body fluid of HTO (3.7×106 Bq/g) intraperitoneally, while the saline as the control. Morris water maze (MWM) was employed for the spatial learning and memory of rats. Results Compared to the control cells, HTO caused a significant downregulation of expressions of cytoskeletal proteins [F-actin (t=8.898-19.896, P<0.05), α-tubulin (t=3.261-7.900, P<0.05), tau (t=2.274-5.003, P<0.05), and MAP2 (t=2.274-5.003, P<0.05)] and mRNA of BDNF(t=3.580-19.792, P<0.05) and Reelin (t=3.240-39.692, P<0.05) in the tested neural cells in a dose-dependent manner. In addition, the escape latency of irradiated offsprings was significantly prolonged (t=-2.563, P<0.05), the time for offsprings to cross through target quadrant was markedly reduced (t=3.214, P<0.05), and the swimming time in the platform quadrant of irradiated offsprings were obviously shortened (t=3.874, P<0.05) in the MWM trial. Conclusions The results indicate that HTO irradiation in utero downregulates the expressions of neuron migration-related factors and induces brain dysfunction, which may shed a light on a mechanism of the radiation-induced brain impairment. Key words: Neuronal cell; Tritiated water; Neuronal migration related factor; Spatial learning and memory
{"title":"Expression of neuronal migration-related factors and the spatial learning and memory of rats prenatally exposed to tritiated water","authors":"Yongsheng Wang, Mingming Wang","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.12.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.12.002","url":null,"abstract":"Objective \u0000To study the expression of neuronal migration-related factors and spatial learning and memory of rats exposed to tritiated water (HTO). \u0000 \u0000 \u0000Methods \u0000Hippocampal neural cells from newborn Sprague-Dawley(SD) rats at postnatal 24 h were primarily cultured in DMEM/F12 medium with 20% of fetal bovine serum for 6 days, followed by subjection to tritiated water(HTO) at concentrations of 3.7×102, 3.7×103, 3.7×104, 3.7×105, 3.7×106 Bq/ml for 24 h, respectively. Western blot and RT-qPCR were used to determine the expression levels of F-actin, α-tubulin, tau, AP2, BDNF mRNA and Reelin mRNA. 16 pregnant SD rats at embryonic (E) day 14 were randomly divided into the tested and control groups (8 rats/ each group). The tested rats were injected with body fluid of HTO (3.7×106 Bq/g) intraperitoneally, while the saline as the control. Morris water maze (MWM) was employed for the spatial learning and memory of rats. \u0000 \u0000 \u0000Results \u0000Compared to the control cells, HTO caused a significant downregulation of expressions of cytoskeletal proteins [F-actin (t=8.898-19.896, P<0.05), α-tubulin (t=3.261-7.900, P<0.05), tau (t=2.274-5.003, P<0.05), and MAP2 (t=2.274-5.003, P<0.05)] and mRNA of BDNF(t=3.580-19.792, P<0.05) and Reelin (t=3.240-39.692, P<0.05) in the tested neural cells in a dose-dependent manner. In addition, the escape latency of irradiated offsprings was significantly prolonged (t=-2.563, P<0.05), the time for offsprings to cross through target quadrant was markedly reduced (t=3.214, P<0.05), and the swimming time in the platform quadrant of irradiated offsprings were obviously shortened (t=3.874, P<0.05) in the MWM trial. \u0000 \u0000 \u0000Conclusions \u0000The results indicate that HTO irradiation in utero downregulates the expressions of neuron migration-related factors and induces brain dysfunction, which may shed a light on a mechanism of the radiation-induced brain impairment. \u0000 \u0000 \u0000Key words: \u0000Neuronal cell; Tritiated water; Neuronal migration related factor; Spatial learning and memory","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"11 1","pages":"887-892"},"PeriodicalIF":0.0,"publicationDate":"2019-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85271573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-25DOI: 10.3760/CMA.J.ISSN.0254-5098.2019.12.003
孙献涛, Sun Xian-tao, 练延帮, Lian Yanbang, 白杨, Bairen Yang, 杨超, Y. Chao, 胡晟云, Huang Shengyun, 王贵宪, Wan Guixian
Objective To study the effect of LncRNA CRNDE on radiosensitivity of colorectal cells and underlying mechanism. Methods Colorectal cancer HT-29 cells were transfected with CRNDE shRNA and the interference efficiency was determined by Real time PCR. HT-29 cells transfected with CRNDE shRNA or co-transfected with CRNDE shRNA and miR-384 inhibitor were irradiated at 8 Gy dose, then cell proliferation and apoptosis were detected by MTT and flow cytometry assay, respectively, and cell radiosensitivity was evaluated by cloning assay. It was predicted by a bioinformatics software that CRNDE and miR-384 have complementary binding sites, and this was identified by a luciferase reporting system. Results CRNDE shRNA reduced the expression of CRNDE in HT-29 cells(1.00±0.08 vs. 0.42±0.06, t=10.051, P<0.05). Both CRNDE shRNA and radiation inhibited the proliferation and induced apoptosis of HT-29 cells, and their combination treatment had synergistic effect in apoptosis induction [Apoptosis rates: (2.27±0.13)%, (23.58±2.35)%, (26.91±2.81)%, (36.84±3.24)%, F=24.660, P<0.05; A values: 0.45±0.06, 0.30±0.02, 0.28±0.03, 0.20±0.02, F=106.207, P<0.05]. Transfection of CRNDE shRNA increased the radiosensitivity of HT-29 cells with a radiosensitization ratio of 1.374. CRNDE negatively regulated the expression of its target miR-384. The miR-384 inhibitor antagonized the effect of CRNDE shRNA on proliferation inhibition and apoptosis promotion of radiation-treated colorectal cancer cells. Conclusions Down-regulation of LncRNA expression enhances the radiosensitivity of colorectal cancer cells by regulating miR-384 expression. Key words: Colorectal cancer; Colorectal neoplasia differentially expressed(CRNDE); miR-384; Radiosensitivity
{"title":"Effect of lncRNA CRNDE targeting miR-384 on radiosensitivity of colorectal cancer cells","authors":"孙献涛, Sun Xian-tao, 练延帮, Lian Yanbang, 白杨, Bairen Yang, 杨超, Y. Chao, 胡晟云, Huang Shengyun, 王贵宪, Wan Guixian","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.12.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.12.003","url":null,"abstract":"Objective \u0000To study the effect of LncRNA CRNDE on radiosensitivity of colorectal cells and underlying mechanism. \u0000 \u0000 \u0000Methods \u0000Colorectal cancer HT-29 cells were transfected with CRNDE shRNA and the interference efficiency was determined by Real time PCR. HT-29 cells transfected with CRNDE shRNA or co-transfected with CRNDE shRNA and miR-384 inhibitor were irradiated at 8 Gy dose, then cell proliferation and apoptosis were detected by MTT and flow cytometry assay, respectively, and cell radiosensitivity was evaluated by cloning assay. It was predicted by a bioinformatics software that CRNDE and miR-384 have complementary binding sites, and this was identified by a luciferase reporting system. \u0000 \u0000 \u0000Results \u0000CRNDE shRNA reduced the expression of CRNDE in HT-29 cells(1.00±0.08 vs. 0.42±0.06, t=10.051, P<0.05). Both CRNDE shRNA and radiation inhibited the proliferation and induced apoptosis of HT-29 cells, and their combination treatment had synergistic effect in apoptosis induction [Apoptosis rates: (2.27±0.13)%, (23.58±2.35)%, (26.91±2.81)%, (36.84±3.24)%, F=24.660, P<0.05; A values: 0.45±0.06, 0.30±0.02, 0.28±0.03, 0.20±0.02, F=106.207, P<0.05]. Transfection of CRNDE shRNA increased the radiosensitivity of HT-29 cells with a radiosensitization ratio of 1.374. CRNDE negatively regulated the expression of its target miR-384. The miR-384 inhibitor antagonized the effect of CRNDE shRNA on proliferation inhibition and apoptosis promotion of radiation-treated colorectal cancer cells. \u0000 \u0000 \u0000Conclusions \u0000Down-regulation of LncRNA expression enhances the radiosensitivity of colorectal cancer cells by regulating miR-384 expression. \u0000 \u0000 \u0000Key words: \u0000Colorectal cancer; Colorectal neoplasia differentially expressed(CRNDE); miR-384; Radiosensitivity","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"57 1","pages":"893-898"},"PeriodicalIF":0.0,"publicationDate":"2019-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87250062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-25DOI: 10.3760/CMA.J.ISSN.0254-5098.2019.12.008
W. Du, X. Gu, Xian-shu Gao, Jie Li, Xueqin Wu
Objective To analyze the therapeutic effect and prognostic factors of induction chemotherapy plus intensity-modulated radiotherapy (IMRT) with or without consolidation chemotherapy for esophageal squamous cell carcinoma (ESCC). Methods One hundred and eight patients with ESCC treated between January 2010 to August 2014 were analyzed retrospectively. All patients received IMRT and platinum-based chemotherapy. The overall survival (OS) and local control (LC) rates were calculated using the Kaplan-Meier method and the univariate prognostic analyses were tested by the Log-rank test. The Cox proportional hazard model was used for multivariate prognostic analysis. Results The follow-up rate was 97.2%. The 1-, 3- and 5-year survival rates were 76.9%, 50.9% and 32.3% respectively, and the LC rates were 73.6%, 58.5% and 54.9% respectively. The median OS with and without consolidation chemotherapy were 51 and 15 months (χ2=5.076, P=0.024), respectively. Multivariate analysis showed that clinical N staging, recent curative effect and consolidation chemotherapy were important prognostic factors for OS, and recent curative effect was associated with LC. The rates of acute grade 3 radiation-induced esophagitis, gastrointestinal side effects, myelosuppression and radiation-induced pulmonary injury were 7.4%, 6.5%, 12% and 0.9%, respectively, and no grade 4 occurred. The late toxicity was mainly radiation-induced pulmonary fibrosis. Conclusions Induction chemotherapy plus IMRT with or without consolidation chemotherapy is safe and effective in the treatment of ESCC. The addition of consolidation chemotherapy may help prolong the survival of some patients and further research is necessary. Individualized treatment should be selected for patients who cannot tolerate or refuse concurrent chemoradiotherapy. Key words: Esophageal neoplasms; IMRT; Induction chemotherapy; Sequential; Prognosis
{"title":"Discussion on the treatment model and prognostic analysis of esophageal squamous cell carcinoma treated with induction chemotherapy combined with intensity-modulated radiation therapy","authors":"W. Du, X. Gu, Xian-shu Gao, Jie Li, Xueqin Wu","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.12.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.12.008","url":null,"abstract":"Objective \u0000To analyze the therapeutic effect and prognostic factors of induction chemotherapy plus intensity-modulated radiotherapy (IMRT) with or without consolidation chemotherapy for esophageal squamous cell carcinoma (ESCC). \u0000 \u0000 \u0000Methods \u0000One hundred and eight patients with ESCC treated between January 2010 to August 2014 were analyzed retrospectively. All patients received IMRT and platinum-based chemotherapy. The overall survival (OS) and local control (LC) rates were calculated using the Kaplan-Meier method and the univariate prognostic analyses were tested by the Log-rank test. The Cox proportional hazard model was used for multivariate prognostic analysis. \u0000 \u0000 \u0000Results \u0000The follow-up rate was 97.2%. The 1-, 3- and 5-year survival rates were 76.9%, 50.9% and 32.3% respectively, and the LC rates were 73.6%, 58.5% and 54.9% respectively. The median OS with and without consolidation chemotherapy were 51 and 15 months (χ2=5.076, P=0.024), respectively. Multivariate analysis showed that clinical N staging, recent curative effect and consolidation chemotherapy were important prognostic factors for OS, and recent curative effect was associated with LC. The rates of acute grade 3 radiation-induced esophagitis, gastrointestinal side effects, myelosuppression and radiation-induced pulmonary injury were 7.4%, 6.5%, 12% and 0.9%, respectively, and no grade 4 occurred. The late toxicity was mainly radiation-induced pulmonary fibrosis. \u0000 \u0000 \u0000Conclusions \u0000Induction chemotherapy plus IMRT with or without consolidation chemotherapy is safe and effective in the treatment of ESCC. The addition of consolidation chemotherapy may help prolong the survival of some patients and further research is necessary. Individualized treatment should be selected for patients who cannot tolerate or refuse concurrent chemoradiotherapy. \u0000 \u0000 \u0000Key words: \u0000Esophageal neoplasms; IMRT; Induction chemotherapy; Sequential; Prognosis","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"1 1","pages":"920-925"},"PeriodicalIF":0.0,"publicationDate":"2019-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89836562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-25DOI: 10.3760/CMA.J.ISSN.0254-5098.2019.12.011
Ying Wang, Xin-wu Mao
{"title":"Investigation and analysis of interventional radiology in Tai′an city","authors":"Ying Wang, Xin-wu Mao","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.12.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.12.011","url":null,"abstract":"","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"16 1","pages":"936-939"},"PeriodicalIF":0.0,"publicationDate":"2019-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85726328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To analyze the levels of entrance surface dose (ESD) to patients from diagnostic medical X-ray examinations in Inner Mongolia autonomous region. Methods The investigation of diagnostic medical X-ray examinations was completed in 30% of the number of hospitals under the requirement of the program plan of the national survey on frequency and dose from medical exposure. The investigation of ESDs to patients from general diagnostic X-ray examinations was carried out in terms of the scale of annual outpatients in different levels of hospital. The difference in ESDs to patients was compared for different equipments, different grade hospitals and different exposure sites, with the comparison result being subjected to rank sum test. Results In all types of diagnostic medical X-ray equipment, DR photography equipment accounted for the majority. During various routine diagnostic X-ray examinations, the average ESDs was lumbar vertebral 3.39 mGy, pelvic and hip 1.65 mGy, cervical spine 0.90 mGy, extremities 0.38 mGy and thorax 0.37 mGy, respectively. In the diagnostic examinations of chest, lumbar and cervical spine, the ESDs caused by the use of screen film photography equipment were higher than those by DR photography equipment, with statistically significant difference (Z=-3.229, -4.820, -5.265, P<0.05). Conclusions Screen film photography equipment results in higher ESD than DR photography equipment. The doctor′s operation behavior is an important factor that affects the ESD. Key words: Inner Mongolia region; Medical exposure; Diagnositc exposure; Entrance surface dose
{"title":"Investigation on entrance surface doses to patients from medical X-ray diagnosis in Inner Mongolia autonomous region","authors":"Xiao Xu, Shuai Zhang, null Haribala, null Gerilemandahu","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.12.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.12.013","url":null,"abstract":"Objective \u0000To analyze the levels of entrance surface dose (ESD) to patients from diagnostic medical X-ray examinations in Inner Mongolia autonomous region. \u0000 \u0000 \u0000Methods \u0000The investigation of diagnostic medical X-ray examinations was completed in 30% of the number of hospitals under the requirement of the program plan of the national survey on frequency and dose from medical exposure. The investigation of ESDs to patients from general diagnostic X-ray examinations was carried out in terms of the scale of annual outpatients in different levels of hospital. The difference in ESDs to patients was compared for different equipments, different grade hospitals and different exposure sites, with the comparison result being subjected to rank sum test. \u0000 \u0000 \u0000Results \u0000In all types of diagnostic medical X-ray equipment, DR photography equipment accounted for the majority. During various routine diagnostic X-ray examinations, the average ESDs was lumbar vertebral 3.39 mGy, pelvic and hip 1.65 mGy, cervical spine 0.90 mGy, extremities 0.38 mGy and thorax 0.37 mGy, respectively. In the diagnostic examinations of chest, lumbar and cervical spine, the ESDs caused by the use of screen film photography equipment were higher than those by DR photography equipment, with statistically significant difference (Z=-3.229, -4.820, -5.265, P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Screen film photography equipment results in higher ESD than DR photography equipment. The doctor′s operation behavior is an important factor that affects the ESD. \u0000 \u0000 \u0000Key words: \u0000Inner Mongolia region; Medical exposure; Diagnositc exposure; Entrance surface dose","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"49 1","pages":"946-950"},"PeriodicalIF":0.0,"publicationDate":"2019-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80951229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-25DOI: 10.3760/CMA.J.ISSN.0254-5098.2019.12.005
朱瑶瑶, Zhu Yaoyao, 杨双燕, Yang Shuang-yan, 杨文艳, Y. Wenyan, 林清认, Lin Qingren, 邵凯南, Shao Kainan, 徐清华, Xu Qinghua, 刘辉, L. Hui, 许亚萍, X. Yaping
Objective To investigate the clinical efficacy and adverse effects of stereotactic body radiotherapy (SBRT) in the treatment of T2N0M0 non-small cell lung cancer (NSCLC) patients. Methods By retrospectively analyzing the clinical data of 30 inoperable patients with stage T2N0M0 NSCLC treated by SBRT, the overall survival, progression-free survival, cancer-specific survival and adverse effects were determined. Results The median follow-up was 18.4 months. The 1-, 2-, and 3-year overall survival rates were 92.2%, 92.2% and 80.6%, respectively. The corresponding cause-specific survivals were 95.7%, 95.7% and 83.7%. The progression-free survivals were 70.2%, 54.1% and 40.6%. The local control rates were 100%, 94.4%, and 94.4%. The regional controls were 84.2%, 72.1%, and 54.1%; and distant controls were 84.6%, 72.4% and 64.3%, respectively. Twenty patients (66.7%) developed symptoms of grade 1 radiation-related toxicities: dyspnea, chest pain, fatigue, cough, esophagitis, or pneumonia. Among these, 5 patients suffered grade ≥2 radiation pneumonitis, and one patient experienced grade 4 radiation pneumonitis. Conclusions SBRT was efficient and safe for patients with inoperable T2N0M0 NSCLC, imposing tolerable toxicities. Key words: Stereotactic body radiation therapy; Non-small cell lung cancer; Overall survival; Progression-free survival; Cause-specific survival
{"title":"Clinical outcomes of stereotactic body radiation therapy for T2N0M0 non-small cell lung cancer","authors":"朱瑶瑶, Zhu Yaoyao, 杨双燕, Yang Shuang-yan, 杨文艳, Y. Wenyan, 林清认, Lin Qingren, 邵凯南, Shao Kainan, 徐清华, Xu Qinghua, 刘辉, L. Hui, 许亚萍, X. Yaping","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.12.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.12.005","url":null,"abstract":"Objective \u0000To investigate the clinical efficacy and adverse effects of stereotactic body radiotherapy (SBRT) in the treatment of T2N0M0 non-small cell lung cancer (NSCLC) patients. \u0000 \u0000 \u0000Methods \u0000By retrospectively analyzing the clinical data of 30 inoperable patients with stage T2N0M0 NSCLC treated by SBRT, the overall survival, progression-free survival, cancer-specific survival and adverse effects were determined. \u0000 \u0000 \u0000Results \u0000The median follow-up was 18.4 months. The 1-, 2-, and 3-year overall survival rates were 92.2%, 92.2% and 80.6%, respectively. The corresponding cause-specific survivals were 95.7%, 95.7% and 83.7%. The progression-free survivals were 70.2%, 54.1% and 40.6%. The local control rates were 100%, 94.4%, and 94.4%. The regional controls were 84.2%, 72.1%, and 54.1%; and distant controls were 84.6%, 72.4% and 64.3%, respectively. Twenty patients (66.7%) developed symptoms of grade 1 radiation-related toxicities: dyspnea, chest pain, fatigue, cough, esophagitis, or pneumonia. Among these, 5 patients suffered grade ≥2 radiation pneumonitis, and one patient experienced grade 4 radiation pneumonitis. \u0000 \u0000 \u0000Conclusions \u0000SBRT was efficient and safe for patients with inoperable T2N0M0 NSCLC, imposing tolerable toxicities. \u0000 \u0000 \u0000Key words: \u0000Stereotactic body radiation therapy; Non-small cell lung cancer; Overall survival; Progression-free survival; Cause-specific survival","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"9 1","pages":"904-909"},"PeriodicalIF":0.0,"publicationDate":"2019-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85678860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-25DOI: 10.3760/CMA.J.ISSN.0254-5098.2019.12.012
Xu Zhe, Song Bin, Z. Yin, Sun Guoqing, W. Zhaoyang, Yao Jianhua, Y. Yuexin
Objective To estimate the effective dose burden to the public in Suzhoui induced by medical exposure from computed tomography (CT) and digital radiography (DR). Methods Twenty-seven hospitals were selected by stratified random sampling. The application information was colleted from picture archiving and communication system (PACS) and radiology information system (RIS). For DR, DAP was measured by the dose-area product meter in different body parts, then the effective dose values were calculated by the DAP. For CT, effective dose was estimated by measuring CT dose index weighted (CTDIw) and scanning parameters in different parts of the body. The public dose burden caused by DR and CT medical exposure in Suzhou was estimated according to the scanning time and effective dose to each part. Results The effective dose due to DR examination was abdomen AP 0.565 mSv, pelvis AP 0.280 mSv, skull LAT 0.016 mSv, skull AP 0.012 mSv, chest LAT 0.111 mSv, chest AP 0.060 mSv, thoracic spine LAT 0.100 mSv, thoracic spine AP 0.102 mSv, lumbar spine LAT 0.307 mSv and lumbar spine AP 0.152 mSv, respectively. The effective doses from CT scanning were 1.33 mSv for head, 5.75 mSv for thorax and 7.31 mSv for abdomen, respectively. The annual collective effective dose in Suzhou in 2017 from DR exposures and CT scans was 9 593.07 man·Sv, and the average annual effective dose was 0.898 mSv. Conclusions The contribution of CT medical radiation to the public dose is much greater than that of DR. Controlling the frequency of medical exposure and single scan dose is an effective way to reduce the public dose burden. The public dose burden from DR and CT medical exposure in Suzhou is at a high level and attention needs to be paid by relevant health administrative departments. Key words: Digital radiography(DR); Computed tomography(CT); Medical exposure; Effective dose
{"title":"Study on public dose burden in Suzhou from medical exposure in X-ray digital radiography and computed tomography","authors":"Xu Zhe, Song Bin, Z. Yin, Sun Guoqing, W. Zhaoyang, Yao Jianhua, Y. Yuexin","doi":"10.3760/CMA.J.ISSN.0254-5098.2019.12.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0254-5098.2019.12.012","url":null,"abstract":"Objective \u0000To estimate the effective dose burden to the public in Suzhoui induced by medical exposure from computed tomography (CT) and digital radiography (DR). \u0000 \u0000 \u0000Methods \u0000Twenty-seven hospitals were selected by stratified random sampling. The application information was colleted from picture archiving and communication system (PACS) and radiology information system (RIS). For DR, DAP was measured by the dose-area product meter in different body parts, then the effective dose values were calculated by the DAP. For CT, effective dose was estimated by measuring CT dose index weighted (CTDIw) and scanning parameters in different parts of the body. The public dose burden caused by DR and CT medical exposure in Suzhou was estimated according to the scanning time and effective dose to each part. \u0000 \u0000 \u0000Results \u0000The effective dose due to DR examination was abdomen AP 0.565 mSv, pelvis AP 0.280 mSv, skull LAT 0.016 mSv, skull AP 0.012 mSv, chest LAT 0.111 mSv, chest AP 0.060 mSv, thoracic spine LAT 0.100 mSv, thoracic spine AP 0.102 mSv, lumbar spine LAT 0.307 mSv and lumbar spine AP 0.152 mSv, respectively. The effective doses from CT scanning were 1.33 mSv for head, 5.75 mSv for thorax and 7.31 mSv for abdomen, respectively. The annual collective effective dose in Suzhou in 2017 from DR exposures and CT scans was 9 593.07 man·Sv, and the average annual effective dose was 0.898 mSv. \u0000 \u0000 \u0000Conclusions \u0000The contribution of CT medical radiation to the public dose is much greater than that of DR. Controlling the frequency of medical exposure and single scan dose is an effective way to reduce the public dose burden. The public dose burden from DR and CT medical exposure in Suzhou is at a high level and attention needs to be paid by relevant health administrative departments. \u0000 \u0000 \u0000Key words: \u0000Digital radiography(DR); Computed tomography(CT); Medical exposure; Effective dose","PeriodicalId":36403,"journal":{"name":"中华放射医学与防护杂志","volume":"1 1","pages":"940-945"},"PeriodicalIF":0.0,"publicationDate":"2019-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89925286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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