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Triiodothyronine, DHEAS/cortisol index and daily oscillations of hormones as markers of adaptation to occupational loads in the Arctic: results of hormonal status study in firefighters-rescuers of EMERCOM of Russia 三碘甲状腺原氨酸、DHEAS/皮质醇指数和激素的日波动作为北极地区职业负荷适应的标志:俄罗斯EMERCOM消防员-救援人员激素状态研究结果
Q3 Health Professions Pub Date : 2023-01-05 DOI: 10.25016/2541-7487-2022-0-3-05-12
S. Aleksanin, N. A. Alhutova, N. A. Kovyazina, V. Rybnikov
Relevance. Considering that prolonged stress of adaptive mechanisms is associated with an increase in the risk of developing somatic pathology, it is relevant to search for laboratory markers that allow assessing the adaptive status of men working in the Arctic and exposed to the combined effects of occupational stress factors and “polar stress”.Intention. To substantiate directions of scientific search for laboratory markers of adaptation to occupational loads in the Arctic.Methodology. A laboratory examination was performed on 74 practically healthy firefighters-rescuers from 22 to 49 years old, working in the Arctic zone of the Russian Federation. Those examined were divided into groups depending on the conditions of occupational activity, as well as triiodothyronine levels, the adaptive androgen dehydroepiandrosterone sulfate (DHEAS) / cortisol index and the cortisol morning/cortisol evening ratio. The results of the hormonal status study were evaluated.Results and Discussion. Significant differences in triiodothyronine levels were revealed between the groups of local and visiting firefighters-rescuers, with no difference in age and concentrations of thyroid-stimulating hormone and free thyroxine.Firefighters-rescuers who were local residents of the Arctic and had low levels of triiodothyronine tended to a relative androgen deficiency. In firefighters-rescuers with preserved adaptive reserves, DHEAS / cortisol index increased with increasing workload in terms of the number of emergency response trips. In rescuers with HEAS / cortisol index < 2.1, there was no such correlation, and higher index values correlated with a more pronounced rhythm of the daily secretion of triiodothyronine and free thyroxine. In the group with the most pronounced daily rhythm of cortisol secretion, a physiological increase in thyroidstimulating hormone concentration was determined in the evening hours along with uniform prolactin secretion throughout the day. A group with a smoother rhythm of cortisol secretion tended to increased evening secretion of prolactin and smoothened rhythm of thyroid-stimulating hormone production.Conclusion. The data obtained are consistent with current ideas about the polysystemic adaptive response, suggest joint activation of the adrenal and pituitary-thyroid mechanisms of adaptation to occupational loads in the Arctic and indicate the necessity of further study and application of the DHEAS / cortisol index and triiodothyronine, as well as daily oscillations of thyroid hormones, thyroid-stimulating hormone and prolactin as markers of adaptation.
的相关性。考虑到适应机制的长期压力与发展成躯体病理的风险增加有关,有必要寻找实验室标记,以评估在北极工作的男性的适应状态,并暴露于职业压力因素和“极地压力”的综合影响下。为北极地区适应职业负荷的实验室标志的科学研究指明方向。对在俄罗斯联邦北极地区工作的74名年龄在22岁至49岁之间几乎健康的消防救援人员进行了实验室检查。研究人员根据职业活动条件、三碘甲状腺原氨酸水平、适应性雄激素脱氢表雄酮硫酸酯(DHEAS) /皮质醇指数和皮质醇早晚比值将这些被调查者分为几组。评估激素状态研究的结果。结果和讨论。三碘甲状腺原氨酸水平在当地和来访的消防救援人员组之间存在显著差异,而年龄和促甲状腺激素和游离甲状腺素的浓度没有差异。消防员和救援人员是北极地区的当地居民,三碘甲状腺原氨酸水平较低,往往相对缺乏雄激素。在保留适应性储备的消防员-救援人员中,DHEAS /皮质醇指数随着应急响应次数的增加而增加。在HEAS /皮质醇指数< 2.1的救援者中,没有这种相关性,指数值越高,每日三碘甲状腺原氨酸和游离甲状腺素分泌的节律越明显。在皮质醇分泌每日节律最明显的一组中,促甲状腺激素浓度的生理增加是在晚上确定的,同时全天催乳素分泌均匀。皮质醇分泌节奏较平缓的组,催乳素分泌增多,促甲状腺激素分泌节奏平缓。所获得的数据与目前关于多系统适应反应的观点一致,提示了北极地区适应职业负荷的肾上腺和垂体-甲状腺联合激活机制,并表明有必要进一步研究和应用DHEAS /皮质醇指数和三碘甲状腺原氨酸,以及甲状腺激素、促甲状腺激素和催乳素的日波动作为适应标志。
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引用次数: 0
Dynamics of the formation of mental disorders in combatants from the Ministry of Internal Affairs of Russia 动态形成的精神障碍的战斗人员从俄罗斯内务部
Q3 Health Professions Pub Date : 2022-08-03 DOI: 10.25016/2541-7487-2022-0-2-52-59
A. A. Rаssokha, E. Ichitovkina, M. Zlokazova, A. Soloviev
Relevance. Participation in hostilities is a stressful factor affecting the formation of mental disorders in combatants. According to scarce studies, combatants resigned from the security forces have some problems with mental health.Intention. Catamnestic analysis of mental disorders over time in combatants entitled to retirement pension upon their dismissal from the Internal Affairs bodies of Russia.Methodology. A catamnestic survey was conducted in 209 employees of the Ministry of Internal Affairs of Russia in the Kirov region who were retired from 2015 to 2019. Depending on participation in hostilities, the respondents were divided into two groups: main group, 106 retired combatants from the Ministry of Internal Affairs of Russia, and the comparison group, 103 retired persons without combat experience. Catamnestic, clinical and experimental psychological research methods were used. Statistical processing of the results was carried out using the STATISTICA 10.0. Mental disorders rates were calculated per 1000 military. Significant differences between the two groups were determined using Pearson’s χ2 and the Student’s t-test.Results and Discussion. According to the study results, the military personnel from the main group had statistically significantly more mental disorders (p < 0.001), as follows: organic, including symptomatic mental disorders (F00–F09 according to ICD-10), neurotic, associated with stress, and somatoform disorders (F40-F48). At the time of dismissal from service, military personnel from the main group had higher rates of all mental disorders (p < 0.001), i.e. organic ones, including symptomatic mental disorders. During the period of service, the groups demonstrated a significant increase in organic, including symptomatic mental disorders, mental and behavioral disorders associated with the use of psychoactive substances (F10–F19), and a decrease in neurotic stress-related and somatoform disorders. In the main group of pensioners of the Ministry of Internal Affairs of Russia, this dynamics is more pronounced. Therefore, there are shortcomings in the treatment of mental disorders during the period of service in the Ministry of Internal Affairs of Russia.Conclusion. In order to improve the quality of psychiatric care for combatants from the Ministry of Internal Affairs of Russia, it is necessary to improve approaches to providing psychiatric care in the structure of departmental multidisciplinary healthcare institutions with amendments to the current procedure for therapy and medical and psychological rehabilitation when returning employees from combat zones.
的相关性。参与敌对行动是影响战斗人员形成精神障碍的压力因素。根据很少的研究,从安全部队辞职的战斗人员有一些心理健康问题。俄罗斯内务机关开除后有权领取退休养恤金的战斗人员长期精神障碍的因果分析。方法。对2015年至2019年在基洛夫地区退休的209名俄罗斯内务部职员进行了纵向调查。根据参与敌对行动的情况,受访者被分为两组:主要组是俄罗斯内务部的106名退休战斗人员,对照组是103名没有战斗经验的退休人员。采用动态、临床和实验心理学研究方法。使用STATISTICA 10.0对结果进行统计处理。计算了每1000名军人的精神障碍率。使用Pearson’s χ2和Student’s t检验确定两组间的显著差异。结果和讨论。研究结果显示,主组军人精神障碍发生率显著高于主组(p < 0.001),其中器质性包括症状性精神障碍(ICD-10分类F00-F09)、神经性包括应激相关精神障碍(F40-F48)。在退役时,主组军人的所有精神障碍发生率较高(p < 0.001),即器质性精神障碍,包括症状性精神障碍。在服务期间,各组显示出器质性,包括症状性精神障碍,与使用精神活性物质相关的精神和行为障碍(F10-F19)的显著增加,以及神经性应激相关和躯体形式障碍的减少。在俄罗斯内政部领取养老金的主要群体中,这种动态更为明显。因此,在俄罗斯内务部服务期间,精神障碍的治疗存在不足。为了提高俄罗斯内务部对战斗人员的精神护理质量,有必要改进在部级多学科保健机构的结构中提供精神护理的方法,修改目前从战区返回的雇员的治疗和医疗及心理康复程序。
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引用次数: 0
Humanitarian consequences of the Syrian crisis 叙利亚危机的人道主义后果
Q3 Health Professions Pub Date : 2022-08-03 DOI: 10.25016/2541-7487-2022-0-2-107-117
N. Goryacheva, Sh. M. Gasanov, N. Bush
Relevance. The main victim of modern armed conflicts is the civilian population. The number of armed conflicts, their scale and severity of consequences steadily increase. The article analyzes the humanitarian consequences and problems of life support for the population of the Syrian Arab Republic during a long armed conflict on its territory. The main factors that led to the difficult humanitarian situation in the country and hindered the initiatives and decisions of political forces and international organizations to stabilize the situation in the country are considered in detail. The importance of political, humanitarian and diplomatic mechanisms in creating favorable conditions for the life support of the population, in accordance with the norms of international law, is confirmed. Particular attention is paid to the analysis of medical support for the population in combat zones in conditions of an acute shortage of medical forces and assets, food and water supplies in the context of full sanctions and a water blockade of the country.Intention: To analyze the main humanitarian consequences of the Syrian crisis and determine priority life support for the population.Methodology. Surveys and statistical analysis were used to assess priority life support of the population under a long-term blockade by terrorist groups on the territory of destroyed settlements. A traditional analysis of documents and literature on the research topic was carried out.Results and Discussion. As a result of the analysis, the main problems in different life support domains were identified. In addition, violations of international humanitarian laws were revealed in the context of an armed conflict (concerning protection of medical personnel, humane treatment of the civilian population, unhindered provision of humanitarian assistance). The role of international humanitarian organizations in solving life support problems has been studied.Conclusion. The material of the article can become an important basis for further study of the priority life support of the population in areas of protracted armed conflicts, taking into account minimum life support indicators necessary to maintain physiological needs, preserve life and maintain public health in an arid climate
的相关性。现代武装冲突的主要受害者是平民。武装冲突的数量、规模和后果的严重程度不断增加。本文分析了在其领土上长期武装冲突期间阿拉伯叙利亚共和国人民的人道主义后果和生命支持问题。详细审议了导致该国人道主义局势困难和阻碍政治力量和国际组织为稳定该国局势而采取的主动行动和作出的决定的主要因素。确认了政治、人道主义和外交机制在根据国际法准则为维持人民的生活创造有利条件方面的重要性。特别注意在全面制裁和对该国实行水封锁的情况下,在医疗部队和资产、粮食和水供应严重短缺的情况下,对战区人口的医疗支助进行分析。目的:分析叙利亚危机的主要人道主义后果,并确定对人口的优先生命支持。利用调查和统计分析来评估在被摧毁的定居点领土上受到恐怖主义集团长期封锁的人民的优先生命支助。对研究课题的文献和文献进行了传统的分析。结果和讨论。通过分析,确定了不同生命维持领域存在的主要问题。此外,还揭露了在武装冲突背景下违反国际人道主义法的行为(涉及保护医务人员、人道对待平民、不受阻碍地提供人道主义援助)。研究了国际人道主义组织在解决生命支持问题中的作用。这篇文章的材料可以成为进一步研究长期武装冲突地区人口优先生命支助问题的重要依据,同时考虑到在干旱气候下维持生理需要、保护生命和维持公众健康所需的最低生命支助指标
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引用次数: 0
Cardiovascular response to whole-body cold exposure in humans with different initial autonomic tone 不同初始自主神经张力的人对全身冷暴露的心血管反应
Q3 Health Professions Pub Date : 2022-08-03 DOI: 10.25016/2541-7487-2022-0-2-93-99
D. Demin
Relevance. Cold exposure increases sympathetic activity and blood pressure. It can also promote intensification of hypertension symptoms and its progress in winter. However, the mechanisms of this phenomenon are poorly understood.Intention: To determine the dynamics of cardiovascular parameters in young people with different initial autonomic regulation of heart rate during experimental general cold exposure.Methodology. 30 healthy male volunteers aged 18–20 years were examined. In accordance with the initial type of autonomic regulation of the heart rate, all subjects were divided into 3 groups as follows: predominance of vagotonia (Group I, n = 9), optimal autonomic regulation – normotonia (Group II, n = 14), predominance of sympathicotonia (Group III, n = 7). The experiment included three stages: rest at a temperature (+20 0C); exposure to cold (–20 0C) for 10 minutes; warming the body (+20 0C). The heart rate variability (HRV) was recorded during each stage of the study using a portable complex “Varicard 2.8” (Russia). At the same time, blood pressure and temperature in the ear canal were recorded.Results and Discussion. Moderate short-term general air cooling causes generally the same type of temporary reactions of central hemodynamics (increase in blood pressure) and indicators of the total HRV power with an increase in parasympathetic activity. Baseline and dynamic values of heart rate and stress index in Group III were significantly higher than in Groups I and II. During body cooling, the stress index in individuals from Group III was 4 times lower, and in individuals from Group I was 1.5 times lower than before cooling. In Group I, baroreflex was less pronounced (slightly decreased heart rate and HRV) along with a significant increase in blood pressure, thus suggesting a high risk of cold-associated vessel injuries. In Groups II and III, a baroreflex was maintained (significant decrease in heart rate and SI) in response to an increase in blood pressure.Conclusion. Apparently, an increase in blood pressure during moderate exposure to cold does not disturb the protective mechanisms of the cardiovascular system in healthy residents of the North with normotonia and predomination of sympathicotonia. At the same time, a week baroreflex in Northerners with vagotonia can be considered at risk for developing cold arterial hypertension.
的相关性。寒冷会增加交感神经活动和血压。它还可以促进冬季高血压症状的加剧和进展。然而,人们对这种现象的机制知之甚少。目的:研究具有不同初始自主心率调节能力的年轻人在实验一般冷暴露过程中心血管参数的动态变化。对30名年龄在18-20岁的健康男性志愿者进行了检查。根据心率自主调节的初始类型,将所有受试者分为迷走神经痛为主组(I组,n = 9)、最佳自主调节-运动正常组(II组,n = 14)、交感神经痛为主组(III组,n = 7)。实验分为3个阶段:静息(+ 200℃);低温(- 200℃)10分钟;温暖身体(+ 200℃)。在研究的每个阶段,使用便携式复杂的“Varicard 2.8”(俄罗斯)记录心率变异性(HRV)。同时记录耳道内血压和温度。结果和讨论。适度的短期一般空气冷却通常引起相同类型的中枢血流动力学暂时反应(血压升高)和总HRV功率指标,伴随副交感神经活动的增加。对照组心率、应激指数基线值、动态值均显著高于对照组和对照组。在降温过程中,III组的应激指数比降温前降低了4倍,I组的应激指数比降温前降低了1.5倍。在第一组中,压力反射不太明显(心率和HRV略有下降),同时血压显著升高,因此提示冷相关血管损伤的风险较高。在II组和III组中,血压升高时维持压力反射(心率和SI显著降低)。显然,在适度暴露于寒冷时,血压升高并不会干扰北方常压和交感张力为主的健康居民心血管系统的保护机制。与此同时,北方地区迷走紧张症患者一周的压力反射可被认为有发生冷动脉高血压的风险。
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引用次数: 0
Organization of the activities of the infectious diseases hospital for the treatment of a new coronavirus infection (COVID-19) at a large construction site 组织传染病医院在大型建筑工地治疗新型冠状病毒感染(COVID-19)的活动
Q3 Health Professions Pub Date : 2022-08-03 DOI: 10.25016/2541-7487-2022-0-2-29-41
A. Grebenyuk, P. V. Shibalov, L. Gritsay, V. G. Okudzhava
Relevance. The emergence of a large number of cases of a new coronavirus infection (COVID-19) required the formation of a new system of medical care and, above all, the creation of infectious hospitals for the treatment of patients with COVID-19.Intention. Analysis of the organization of the work of a temporary infectious diseases hospital for the treatment of COVID-19 in workers involved in the construction of the Amur Gas Processing Plant (AGPP). Methodology. The object of the study was a temporary infectious diseases hospital organized for the diagnosis and treatment of COVID-19 in workers mobilized for the construction of AGPP. During the study period from March 2020 to April 2022, the total number of employees participating in construction work daily at AGPP ranged from 17,759 to 39,437 people. Construction personnel worked on a rotational basis, the duration of the shift was from 2 to 6 months. Along with citizens of the Russian Federation, citizens of foreign countries from near and far abroad worked on the site. All shift workers lived in hostels on the territory of temporary construction camps, ate in common canteens. Development of the organizational and staff structure, completeness of medical equipment, medicines and property, evaluation of the effectiveness of the temporary infectious hospital performed using the methods of historical analysis and comparison, system and logical analysis, and expert evaluations. Results and Discussion. The results of a retrospective analysis of the measures for the construction and organization of the work of the temporary infectious disease hospital at the AGPP site presented. The hospital built based on a quickly erected building of block-modular type, passed sanitary-epidemiological examination and licensing in 45 days. The hospital has two departments with 44 beds each for the treatment of patients with COVID-19 (88 beds in total), an intensive care unit with 6 beds, two isolation wards with 2 beds each, a clinical and diagnostic laboratory that allows conducting studies by polymerase chain reaction (PCR) methods and immunofluorescence assay (ELISA), as well as the full range of general clinical laboratory tests, computed tomography unit, vaccination unit, medical gas supply station. The organizational and staffing structure and the number of medical personnel changed dynamically, depending on the epidemiological situation and the arising tasks of medical support of AGPP workers; at maximum staffing the hospital had 22 doctors, 1 pharmacist, 45 nurses, 30 paramedics and support personnel. From July 12, 2020 to April 10, 2022, inpatient treatment received 2622 people in the hospital’s infectious disease departments, and 198 people in the intensive care unit. Outpatient treatment provided to 4127 workers, of which 462 hospitalized for inpatient treatment and 3665 discharged to work upon recovery. There are 17,893 lung examinations including 12,582 primary and 5311 repeated (control) examinations per
的相关性。大量新型冠状病毒感染(COVID-19)病例的出现,需要形成新的医疗保健体系,最重要的是,需要建立治疗COVID-19患者的感染性医院。阿穆尔河天然气加工厂(AGPP)建设工人COVID-19临时传染病医院工作组织分析方法。本研究的对象是为AGPP建设动员的工人中COVID-19的诊断和治疗而组织的临时传染病医院。在2020年3月至2022年4月的研究期间,AGPP每天参与建筑工作的员工总数为17,759至39,437人。施工人员实行轮岗制,轮班时间为2 - 6个月。与俄罗斯联邦公民一起,来自远近的外国公民在现场工作。所有轮班工人住在临时建筑营地的招待所,在公共食堂吃饭。组织和人员结构的发展,医疗设备,药品和财产的完整性,使用历史分析和比较,系统和逻辑分析以及专家评估的方法对临时感染医院的有效性进行评估。结果和讨论。对AGPP现场传染病临时医院的建设和组织工作措施进行了回顾性分析。该医院是在快速搭建的块模块式建筑基础上建造的,在45天内通过了卫生流行病学检查和许可。医院设有2个科室,各44张床位(共88张床位),1个重症监护病房(6张床位),2个隔离病房(2张床位),1个临床和诊断实验室(可进行聚合酶链反应(PCR)和免疫荧光法(ELISA)研究),以及全面的临床综合实验室、计算机断层扫描单元、疫苗接种单元、医用供气站。根据流行病学形势和新出现的AGPP工作人员医疗支持任务,组织编制结构和医务人员数量发生动态变化;医院最多有22名医生、1名药剂师、45名护士、30名护理人员和支助人员。2020年7月12日至2022年4月10日,医院传染病科住院治疗2622人,重症监护室住院治疗198人。为4127名工人提供门诊治疗,其中462人住院治疗,3665人康复后出院上班。共有17,893例肺部检查,其中12,582例进行了原发性检查,5311例进行了重复(对照)检查,并在计算机断层扫描单元检测到6547例病毒性肺炎。临床和诊断实验室开展PCR检测302695项,ELISA检测IgM和IgG水平14037项,普通临床血液学和生化检测9065项,凝血仪检测7832项,评估新冠肺炎炎症反应特征特异性标志物20782项。医院医务人员为AGPP的42620名工作人员进行了大规模流感疫苗接种,为13678名工作人员接种了“人造卫星”疫苗的第一组分,为12598名工作人员接种了“人造卫星”疫苗的第二组分,为19214名工作人员接种了COVID-19疫苗。结论。在快速建成的建筑基础上建造了临时传染病医院,配备了现代化的医疗设备和药品,配备了高素质的医务人员,从而可以组织COVID-19的实验室和仪器诊断,对患者进行住院和门诊治疗,并为参与实施AGPP项目的所有承包商的轮班工人接种疫苗。
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引用次数: 1
The system of organizing the provision of medical care to victims in traffic accidents on federal highways in regions of Russia with low population density 在俄罗斯人口密度低的地区组织向联邦公路交通事故受害者提供医疗服务的制度
Q3 Health Professions Pub Date : 2022-08-03 DOI: 10.25016/2541-7487-2022-0-2-22-28
A. Baranov
Relevance. Road traffic injuries are one of the leading non-natural causes of death in the world. The principles of organizing the provision of medical care to victims of road traffic accidents (RTA) should be adapted to the resource capabilities of regional health care systems, as well as the distribution of the resident population across the territory.Intention: To develop and substantiate the principles of a system for organizing the provision of medical care to RTA victims on federal highways in Russian regions with a low average population density.Methodology. The results of our own, domestic and foreign scientific research were reviewed, along with regulatory legal documents on the organization of medical care for RTA victims in various conditions. Articles published in 1990–2021 were selected for analysis. Information sources were searched for using specialized scientific search engines (eLibrary, PubMed, Scopus) with the keywords: “traffic accident”, “traffic injury”, “polytrauma”, “federal highway”, “injured”, “hospital period “. System analysis was used to determine the shortcomings of the existing system of providing medical care to victims of road accidents that occurred on federal highways in the territories of Russian subjects with a low population density. Organizational experiments were used to substantiate and develop measures, the implementation of which will improve the efficiency of providing first aid and medical care to victims of road accidents on federal highways in Russian regions with a low population density.Results and Discussion. A system for organizing the provision of medical care to victims of road accidents on federal highways in the regions of the Russian Federation with a low density of the population in the pre-hospital and hospital periods has been developed and justified; it consists of 4 principles and their organizational measures.Conclusion. The implementation of the model and the principles of the developed system proposed by the author will reduce negative health consequences associated with road traffic injuries on federal highways in Russian regions with low population density.
的相关性。道路交通伤害是世界上主要的非自然死亡原因之一。组织向道路交通事故受害者提供医疗护理的原则应适应区域保健系统的资源能力,以及整个领土的常住人口分布。目的:制定和落实一个系统的原则,以便在俄罗斯平均人口密度低的地区向联邦公路上的RTA受害者提供医疗服务。审查了我们自己、国内和国外的科学研究结果,以及关于在各种情况下为RTA受害者组织医疗保健的规范性法律文件。选取1990-2021年发表的文章进行分析。使用专门的科学搜索引擎(eLibrary, PubMed, Scopus)搜索信息来源,关键词为:“交通事故”,“交通伤害”,“多重创伤”,“联邦公路”,“受伤”,“住院期间”。系统分析是用来确定现有系统的缺陷提供医疗事故的受害者,发生在俄罗斯联邦高速公路上的低人口密度的主体领土。利用组织试验来证实和制定措施,这些措施的实施将提高向俄罗斯人口密度低的地区联邦公路上道路事故受害者提供急救和医疗护理的效率。结果和讨论。在俄罗斯联邦人口密度较低的地区,已经建立并证明了在入院前和住院期间组织向联邦公路上的道路事故受害者提供医疗服务的制度;它包括4个原则及其组织措施。实施作者提出的模式和发达系统的原则将减少俄罗斯人口密度低地区联邦公路上道路交通伤害对健康的负面影响。
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引用次数: 0
The possibilities of using bioengineered skin substitutes in combustiology (literature review) 生物工程皮肤替代品在燃烧学中的应用前景(文献综述)
Q3 Health Professions Pub Date : 2022-08-03 DOI: 10.25016/2541-7487-2022-0-2-82-92
S. G. Shapovalov, A. V. Kcheuso, T. E. Koshelev, D. K. Savchenkov
Relevance. Despite scientific and technological progress and improvement of treatment methods, providing assistance for thermal burns of the skin remains a complex multicomponent problem. Extensive deep burns are not capable of self-healing, and therefore, over the past century, autodermoplasty has become the standard method of treatment. However, the shortage of healthy tissues of the patient often does not allow the transplantation to be performed in full, which entails the need to search for options for replacing auto-tissues.Intention. To present modern possibilities and evaluate the problems of using bioengineered skin substitutes in kombustiology.Methodology. Scientific literary sources published in recent years were searched for using the PubMed database and the platform of Scientific Electronic Library (eLIBRARY.ru ).Results and Discussion. Currently, many skin substitutes have been developed, ranging from single-layer tissue equivalents to artificial leather and genetically modified substitutes. However, all of them are still far from perfect, they have their advantages and disadvantages, which determine the features of their application and necessitate further research.Conclusion. The development of tissue equivalents of the skin has significantly improved the results of treatment of victims with deep burns and is a promising direction in the development of modern combustiology.
的相关性。尽管科学技术的进步和治疗方法的改进,但对皮肤热烧伤的辅助治疗仍然是一个复杂的多组分问题。大面积的深度烧伤不能自愈,因此,在过去的一个世纪里,自体皮肤成形术已经成为标准的治疗方法。然而,由于患者健康组织的短缺,通常不能完全进行移植,这就需要寻找替代自身组织的选择。介绍生物工程皮肤替代品在微生物学中的应用的现代可能性和问题。利用PubMed数据库和科学电子图书馆(eLIBRARY.ru)平台检索近年来发表的科学文献资源。结果和讨论。目前,已经开发了许多皮肤替代品,从单层组织等效物到人造皮革和转基因替代品。然而,它们都还远远不够完善,它们各有优缺点,这决定了它们的应用特点,需要进一步的研究。皮肤组织等效物的发展显著改善了深度烧伤患者的治疗效果,是现代燃烧学发展的一个有希望的方向。
{"title":"The possibilities of using bioengineered skin substitutes in combustiology (literature review)","authors":"S. G. Shapovalov, A. V. Kcheuso, T. E. Koshelev, D. K. Savchenkov","doi":"10.25016/2541-7487-2022-0-2-82-92","DOIUrl":"https://doi.org/10.25016/2541-7487-2022-0-2-82-92","url":null,"abstract":"Relevance. Despite scientific and technological progress and improvement of treatment methods, providing assistance for thermal burns of the skin remains a complex multicomponent problem. Extensive deep burns are not capable of self-healing, and therefore, over the past century, autodermoplasty has become the standard method of treatment. However, the shortage of healthy tissues of the patient often does not allow the transplantation to be performed in full, which entails the need to search for options for replacing auto-tissues.Intention. To present modern possibilities and evaluate the problems of using bioengineered skin substitutes in kombustiology.Methodology. Scientific literary sources published in recent years were searched for using the PubMed database and the platform of Scientific Electronic Library (eLIBRARY.ru ).Results and Discussion. Currently, many skin substitutes have been developed, ranging from single-layer tissue equivalents to artificial leather and genetically modified substitutes. However, all of them are still far from perfect, they have their advantages and disadvantages, which determine the features of their application and necessitate further research.Conclusion. The development of tissue equivalents of the skin has significantly improved the results of treatment of victims with deep burns and is a promising direction in the development of modern combustiology.","PeriodicalId":36526,"journal":{"name":"Medico-Biological and Socio-Psychological Issues of Safety in Emergency Situations","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72904380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristic features of psychological and psychiatric care for military personnel in modern armed conflicts 现代武装冲突中军事人员心理和精神护理的特点
Q3 Health Professions Pub Date : 2022-08-03 DOI: 10.25016/2541-7487-2022-0-2-60-71
V. Shamrey, A. Marchenko, V. Yusupov, Yu. L. Starenchenko, E. A. Chernyavsky
Relevance. The problem of improving the military personnel psychological and psychiatric care in combat conditions is due to high levels of psychogenic losses, sometimes up to 80 % of the combatants. At the same time, insufficient theoretical development of the problem of reactive states in the combat situation, unclear definitions and boundaries, pronounced differences in terminology, classification and methodological approaches used by different specialists significantly impede specialized care.Intention. Based on the analysis of current conception about combat related stress-induced mental disorders in military personnel, to develop proposals for organizing a staged system for providing psychological and psychiatric care from the standpoint of modern military medical doctrine.Methodology. Approaches to systematization of stress-induced disorders and the related system of psychological and psychiatric care organization were analyzed using a heuristic method. Results and Discussion. Based on the analysis of taxonomic and severity characteristics of stress-induced disorders, 2 subgroups were identified – short-term and prolonged ones, as well as 4 organizational categories (levels) in accordance with the type of required care: psychological, preclinical, borderline (neurotic) and psychotic. It is proposed to consider the first category as not requiring medical and psychological care, the second - as related to short-term casualties (psychogenic losses), the third - mainly to psychiatric sanitary casualties, and the fourth, mainly to irrecoverable casualties. The content of psychological and psychiatric care at the stages of medical evacuation in relation to the selected categories of the casualties is revealed. An idea is given about psychological and psychiatric intelligence, probable factors that need to be taken into account in prediction of psychogenic losses, and an example of such a calculation is given.Conclusion. It is stated that the existing approaches to psychogenic losses prediction do not take into account organizational and staffing changes in the troops and modern forms and methods of armed confrontation. The necessity of developing objective methods for predicting individual resistance to combat negative factors, remote monitoring of the military personnel mental health, as well as improving methods of treatment and prompt correction of stress-induced disorders, including those based on a mobile psychoprophylactic platform, is postulated.
的相关性。改善军事人员在战斗条件下的心理和精神护理的问题是由于高水平的心理损失,有时高达80%的战斗人员。与此同时,在战斗情况下反应状态问题的理论发展不足,定义和边界不明确,不同专家使用的术语、分类和方法方法的明显差异,严重阻碍了专业化护理。在分析当前军人作战应激性精神障碍观念的基础上,从现代军事医学学理的角度,提出构建分阶段心理精神护理体系的建议。运用启发式方法分析了应激性障碍的系统化途径以及相关的心理和精神护理机构体系。结果和讨论。通过对应激障碍的分类和严重程度特征的分析,将应激障碍分为短期亚组和长期亚组,并根据需要的护理类型划分为心理、临床前、边缘性(神经性)和精神病性4个组织类别(水平)。建议将第一类视为不需要医疗和心理护理,第二类-与短期伤亡(心理损失)有关,第三类-主要是精神卫生伤亡,第四类-主要是不可恢复的伤亡。报告揭示了在医疗后送阶段对选定类别的伤亡人员进行心理和精神护理的内容。提出了心理和精神智力的概念,以及在预测因心性损失时可能需要考虑的因素,并给出了计算的一个例子。有人指出,现有的心理损失预测方法没有考虑到部队的组织和人员配置变化以及武装对抗的现代形式和方法。假定有必要制定客观方法来预测个人对战斗消极因素的抵抗力,远程监测军事人员的心理健康,以及改进治疗和及时纠正应激性障碍的方法,包括基于移动精神预防平台的方法。
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引用次数: 2
Diagnostic algorithm for determining the risk of developing pathological types of scar tissue in patients with burn injury 确定烧伤患者瘢痕组织病理类型发展风险的诊断算法
Q3 Health Professions Pub Date : 2022-08-03 DOI: 10.25016/2541-7487-2022-0-2-100-106
Y. V. Yurova, V. Ilina, E. V. Zinovev, R. V. Vashetko
Relevance. The problem of the development of pathological scar tissue in combustiology is still relevant. It is necessary to determine a pathogenetically sound approach to the treatment of a burn wound that reduces the likelihood of the development of pathological scar tissue.Intention: To study the histological structure of the tissues from which skin scars are formed, to develop a diagnostic algorithm for predicting the development of pathological scars.Methodology. Tissue biopsies taken intraoperatively in the center and along the periphery of burn wounds before free autodermoplasty (FADP) were examined in 56 patients with burn injuries. In the selection zone, microcirculation parameters were determined by laser Doppler flowmetry (LDF) at the stage of treatment of burn wounds and during the formation of scar tissue. Clinical observation of patients was carried out for a year. Relationships between histology of tissues from which the scar would subsequently form, their perfusion indices before FADP and types of scar tissue were assessed over a year.Results and Discussion. It was revealed that pathological scar tissue develops from granulation tissue and fibrous-altered dermis. The possibility of predicting the formation of the type of scar tissue by determining perfusion (M) is shown: above 10 perfusion units (PE), pathological scar tissue arises from granulation tissue; less than 4 PE, a high risk of developing pathological scar tissue from fibrous-altered dermis. With perfusion (4≤M≤10) in the zone of burn defects, the dermis, elements of subcutaneous fat, fibrous layer of granulation tissue are histologically determined, and the risk of developing pathological scar tissue is minimal.Conclusion. Taking into account the revealed patterns, principles for predicting the formation of pathological scar tissue were justified based on perfusion parameters in various parts of the burn wound and histology at the early stages of treatment. Based on the results, an algorithm for diagnosing various types of scar tissue has been developed
的相关性。病理瘢痕组织的发展问题在燃烧学中仍然具有重要意义。有必要确定一种病理上合理的方法来治疗烧伤伤口,以减少病理性瘢痕组织发展的可能性。目的:研究皮肤瘢痕形成组织的组织学结构,发展一种预测病理性瘢痕发展的诊断算法。对56例烧伤患者行游离自体真皮成形术(FADP)前术中烧伤创面中心及周围组织活检。在选择区,采用激光多普勒血流仪(LDF)测定烧伤创面治疗阶段和瘢痕组织形成阶段的微循环参数。对患者进行为期一年的临床观察。在一年多的时间里,评估随后形成疤痕的组织组织学、FADP前的灌注指数和疤痕组织类型之间的关系。结果和讨论。病理瘢痕组织由肉芽组织和纤维改变的真皮发展而来。通过测定灌注量(M)预测瘢痕组织类型形成的可能性显示:10个灌注单位(PE)以上,病理性瘢痕组织由肉芽组织产生;小于4pe,从纤维改变的真皮发展为病理性瘢痕组织的风险很高。烧伤缺损区灌注量(4≤M≤10),真皮、皮下脂肪成分、肉芽组织纤维层组织学上确定,发生病理性瘢痕组织的风险最小。考虑到所揭示的模式,基于烧伤创面各部位的灌注参数和治疗早期的组织学,预测病理性瘢痕组织形成的原则是合理的。在此基础上,开发了一种诊断各种类型疤痕组织的算法
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引用次数: 0
Diagnostic ultrasound examinations during evacuation of urgent patients by ambulance helicopters: literature review 救护车直升机疏散急诊患者时的超声诊断检查:文献回顾
Q3 Health Professions Pub Date : 2022-08-03 DOI: 10.25016/2541-7487-2022-0-2-42-51
S. A. Gumenyuk, S. Aleksanin, A. M. Schikota, V. Yarema, I. Pogonchenkova
Relevance. The use of ultrasound diagnostics at the place of providing medical care to an urgent patient is one of the promising directions in the development of emergency medicine. At the same time, of particular interest is the possibility of using diagnostic ultrasound in an ambulance helicopter, given the lack of clear algorithms and standards for its application, as well as the limited number of publications on this problem.Intention. Analysis of publications on the use of urgent ultrasound examination in an ambulance helicopter.Methodology. A search was made for scientific publications on the topic on the electronic resource PubMed, in the Google Scholar search system for the period from 2000 to 2021.Results and discussion. The main algorithms used for ultrasound diagnostics of an urgent patient in an ambulance helicopter are Focused Assessment with Sonography for Trauma (FAST), point-of-care ultrasound (POCUS), Rapid Ultrasound in SHock (RUSH), Bedside Lung Ultrasound in Emergency (BLUЕ), prehospital ultrasonography (PHUS), etc. They help exclude damage to vital organs and emergency pathology – pneumo- and hemothorax, hemoperitoneum, hemopericardium, large fractures and others that affect the tactics of treatment and patient routing; there is also the possibility of ultrasound navigation for a number of medical and diagnostic procedures. According to the results of published studies and clinical observations, prehospital ultrasound examination of urgent patients is successfully used during medical evacuation by an ambulance helicopter in emergency medical services in many countries of the world (both by doctors and other medical personnel), making it possible to diagnose a number of lifethreatening conditions with a fairly high accuracy, without loss of time and without damage to patient’s health. An important aspect of the successful application of the method during flight is the training of qualified personnel. The prospects for the development of the method are the development of more advanced ultrasound scanners and sensors adapted to flight conditions, as well as the use of telemedicine technologies for remote analysis of ultrasound images.Conclusion. The experience of using prehospital diagnostic ultrasound in an ambulance helicopter requires further data accumulation and systematic analysis, but the method is already undoubtedly useful in determining the tactics of treatment and the route of hospitalization of urgent patients with acute trauma and a number of other pathological conditions.
的相关性。超声诊断在为急症患者提供医疗服务的地方的应用是急诊医学发展的一个有前途的方向。与此同时,特别令人感兴趣的是在救护直升机上使用诊断超声的可能性,因为它的应用缺乏明确的算法和标准,而且关于这个问题的出版物数量有限。救护直升机上使用紧急超声检查的出版物分析。方法学。在谷歌学术搜索系统中检索了2000年至2021年期间在电子资源PubMed上关于该主题的科学出版物。结果和讨论。用于救护直升机上急诊患者超声诊断的主要算法有创伤超声集中评估(FAST)、护理点超声(POCUS)、休克快速超声(RUSH)、急诊床边肺超声(BLUЕ)、院前超声(PHUS)等。它们有助于排除对重要器官的损害和紧急病理——肺炎——以及胸血、腹膜血、心包血、大骨折和其他影响治疗策略和病人路线的因素;在一些医疗和诊断程序中,超声波导航也是可能的。根据已发表的研究和临床观察的结果,在世界上许多国家的紧急医疗服务中,救护车直升机(医生和其他医务人员)在医疗后送期间成功地使用了对紧急病人的院前超声检查,从而能够以相当高的准确性诊断出一些危及生命的疾病,而不浪费时间,也不损害病人的健康。在飞行中成功应用该方法的一个重要方面是培训合格人员。该方法的发展前景是开发更先进的适应飞行条件的超声扫描仪和传感器,以及使用远程医疗技术对超声图像进行远程分析。在救护直升机上使用院前超声诊断的经验需要进一步的数据积累和系统分析,但该方法在确定急性创伤和许多其他病理状况的紧急患者的治疗策略和住院路线方面无疑是有用的。
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引用次数: 0
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Medico-Biological and Socio-Psychological Issues of Safety in Emergency Situations
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