R. Yadav, Arun Kumar Yadav, Dharam Pal Pathak, Rajesh Arora
Cold injury refers to local or systemic body response that occurs due to massive loss of body heat when the body is exposed to extremely cold temperatures. The current modalities for the prevention and management of cold injury(ies) are very limited due to the paucity of availability of targeted therapeutics. Pathophysiological cascades in cold injury include: (a) desensitization of sensory neurons can be manifest as a result of altered pathophysiological functions viz., Ca2+ imaging, calcitonin gene-related peptide release, expressions of inflammatory mediators (PGE2: prostaglandin E2, NGF: nerve growth factors), (b) inflammatory markers viz.; interleukins (IL-1β, IL-6, and IL-10), tumor necrosis factor-alpha (TNF-α), and CD62E/endothelial-leukocyte adhesion molecule 1 (E-selectin); (c) oxidative stress markers associated with cold injury measured through serum level of protein carbonyl, 4-hydroxy-2-nonenal (4-HNE), superoxide dismutase (SODs), advanced oxidative protein products (AOPP) and nitrotyrosine; (d) endothelial damage: nitric oxide (NO), prostacyclin (PGI2), reactive oxygen species (ROS), Von-Willebrand factor (VWF), CD31/PECAM-1 (platelet/endothelial cell adhesion molecule 1), CD36/SR-B3 (scavenger receptor class B member 3) and tissue-type plasminogen activator (TTPA). In this review paper, we elaborate on the current state-of-the-art pharmacological interventions for cold injury that may be beneficial in developing novel and targeted therapeutics for the prevention, management, and treatment of cold injury.
{"title":"Cold Injury Prevention and Management in High Altitude Extreme Environments Pharmacological and Therapeutical Interventions","authors":"R. Yadav, Arun Kumar Yadav, Dharam Pal Pathak, Rajesh Arora","doi":"10.14429/dlsj.9.19450","DOIUrl":"https://doi.org/10.14429/dlsj.9.19450","url":null,"abstract":"Cold injury refers to local or systemic body response that occurs due to massive loss of body heat when the body is exposed to extremely cold temperatures. The current modalities for the prevention and management of cold injury(ies) are very limited due to the paucity of availability of targeted therapeutics. Pathophysiological cascades in cold injury include: (a) desensitization of sensory neurons can be manifest as a result of altered pathophysiological functions viz., Ca2+ imaging, calcitonin gene-related peptide release, expressions of inflammatory mediators (PGE2: prostaglandin E2, NGF: nerve growth factors), (b) inflammatory markers viz.; interleukins (IL-1β, IL-6, and IL-10), tumor necrosis factor-alpha (TNF-α), and CD62E/endothelial-leukocyte adhesion molecule 1 (E-selectin); (c) oxidative stress markers associated with cold injury measured through serum level of protein carbonyl, 4-hydroxy-2-nonenal (4-HNE), superoxide dismutase (SODs), advanced oxidative protein products (AOPP) and nitrotyrosine; (d) endothelial damage: nitric oxide (NO), prostacyclin (PGI2), reactive oxygen species (ROS), Von-Willebrand factor (VWF), CD31/PECAM-1 (platelet/endothelial cell adhesion molecule 1), CD36/SR-B3 (scavenger receptor class B member 3) and tissue-type plasminogen activator (TTPA). In this review paper, we elaborate on the current state-of-the-art pharmacological interventions for cold injury that may be beneficial in developing novel and targeted therapeutics for the prevention, management, and treatment of cold injury.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140526303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abul Qasim, Sushila Rani, Richa Puri, Manoj Kumar Patel, Rakesh Kumar Behera, Om Prakash Chaurasia
The present study discusses the agro technique, harvesting, yield, and economics of less explored highly medicinal plant black goji berry (Lycium ruthenicum). It was observed that black goji berries can be easily cultivated through seed, pencil-thickness hardwood stem cuttings, and rootstock. Black goji berry harvesting is a very difficult and tedious task for goji growing farmers as the berries get easily ruptured during harvesting and lose their content. To address these obstacles, DIHAR-DRDO, Leh conducted several goji berry harvesting trials deploying various techniques. Collecting fruits/berries to their full potential requires careful planning and tactics, which involves the use of an appropriate harvesting method that minimizes damage. After performing various method of harvesting, the best outcome was reported in cutting the fruit-bearing branch method as its less expensive with minimum fruit damage (5 %), time-saving, and retain the quality of fruit as compared to the other harvesting methods. An approximate cost production and net profit calculation were performed for 1011.71 square meters (02 Kanal) plantations of L. ruthenicum to their average yield of fruit production per plant. The average yield of three-year-old hardwood stem cutting and uprooted plant is 500-600 gm of fresh berry per plant on average. The economic relation to the cost production of L. ruthenicum is highly beneficial and it has all the capabilities of enhancing the socio-economy of the fragile ecosystem.
{"title":"Cultivation of Black Goji Berry (Lycium Ruthenicum Murr.) in the Trans Himalayan Region Ladakh Agro Technique Harvest, Yield and Cost Benefit Analysis","authors":"Abul Qasim, Sushila Rani, Richa Puri, Manoj Kumar Patel, Rakesh Kumar Behera, Om Prakash Chaurasia","doi":"10.14429/dlsj.8.18302","DOIUrl":"https://doi.org/10.14429/dlsj.8.18302","url":null,"abstract":"The present study discusses the agro technique, harvesting, yield, and economics of less explored highly medicinal plant black goji berry (Lycium ruthenicum). It was observed that black goji berries can be easily cultivated through seed, pencil-thickness hardwood stem cuttings, and rootstock. Black goji berry harvesting is a very difficult and tedious task for goji growing farmers as the berries get easily ruptured during harvesting and lose their content. To address these obstacles, DIHAR-DRDO, Leh conducted several goji berry harvesting trials deploying various techniques. Collecting fruits/berries to their full potential requires careful planning and tactics, which involves the use of an appropriate harvesting method that minimizes damage. After performing various method of harvesting, the best outcome was reported in cutting the fruit-bearing branch method as its less expensive with minimum fruit damage (5 %), time-saving, and retain the quality of fruit as compared to the other harvesting methods. An approximate cost production and net profit calculation were performed for 1011.71 square meters (02 Kanal) plantations of L. ruthenicum to their average yield of fruit production per plant. The average yield of three-year-old hardwood stem cutting and uprooted plant is 500-600 gm of fresh berry per plant on average. The economic relation to the cost production of L. ruthenicum is highly beneficial and it has all the capabilities of enhancing the socio-economy of the fragile ecosystem.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135493629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Biofilm is defined as a community of microorganisms that are adhered to living or non-living solid surfaces and embedded in a common, self-made matrix, comprising of exopolysaccharide material. The role of biofilm in chronic diseases deserves special importance as these extracellular polymeric materials developed with quorum sensing support both the primary criteria of infection development namely adhesion and colonisation. Due to their structural and physiological changes, microorganisms present in the biofilm are difficult to treat or eradicate. The presence of a protective layer of extracellular polymers, changes in metabolic activity or a high rate of mutation make them tolerant or resistant to conventional treatment. The persistence of pathogenic microorganisms mostly renders biofilm to be associated with several acute and chronic infections and various nosocomial or healthcare-related infections. Furthermore, cancer development may also result due to biofilm formation. Biofilm may contribute to inflammation. This study deals with molecular aspects of biofilm formation and its role in different disease formations.
{"title":"Biofilm Formation in Acute and Chronic Infections with Special Emphasis on Common Chronic and Nosocomial Infections","authors":"Parama Das Gupta, Upal Das Ghosh, Rini Roy","doi":"10.14429/dlsj.8.18431","DOIUrl":"https://doi.org/10.14429/dlsj.8.18431","url":null,"abstract":"Biofilm is defined as a community of microorganisms that are adhered to living or non-living solid surfaces and embedded in a common, self-made matrix, comprising of exopolysaccharide material. The role of biofilm in chronic diseases deserves special importance as these extracellular polymeric materials developed with quorum sensing support both the primary criteria of infection development namely adhesion and colonisation. Due to their structural and physiological changes, microorganisms present in the biofilm are difficult to treat or eradicate. The presence of a protective layer of extracellular polymers, changes in metabolic activity or a high rate of mutation make them tolerant or resistant to conventional treatment. The persistence of pathogenic microorganisms mostly renders biofilm to be associated with several acute and chronic infections and various nosocomial or healthcare-related infections. Furthermore, cancer development may also result due to biofilm formation. Biofilm may contribute to inflammation. This study deals with molecular aspects of biofilm formation and its role in different disease formations.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135493633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Simran R Lilwani, Muzammil Ahmad Shaikh Khan, Parvathi J. R., Madhavi R. Vernekar
A Dye-Sensitised Solar Cell (DSSC) is a low-cost thin film solar cell that works in diffused light and comes in a variety of colors. Most of the investigations on organic dye-based DSSC have used pigments from flowers and fruits as photosensitizers. With the majority of the world's economy reliant on agriculture to meet the food and feed demand, using agricultural resources for color extraction is not a realistic solution. Alternative dye resources, such as microorganisms, must thus be investigated in DSSCs to ensure a long-term future. The present study was a preliminary investigation to explore the potential of carotenoids derived from an actinobacteria Rhodococcus kroppenstedtii as a photosensitizer in a DSSC. The carotenoid extract from R. kroppenstedtii was subjected to stability analysis, to ascertain its potential as a photosensitizer. The extract was found to be stable at varying temperatures (0-80 °C), pH (3-11), and light conditions (dark, white light, sunlight), indicating its potential applicability as a photosensitizer. Further, increasing concentrations (12.5 mg/mL-100 mg/mL) of the extract was used for sensitization of TiO 2 in a DSSC assembly. The extract showed a linear rise in power output (078±0.0001 - 20.75±0.0003 mW), which proposes its scope as a stable and cheap photosensitizer in a DSSC.
{"title":"Exploring Carotenoid from Rhodococcus Kroppenstedtii as a Photosensitizer in a Dye Sensitised Solar Cell","authors":"Simran R Lilwani, Muzammil Ahmad Shaikh Khan, Parvathi J. R., Madhavi R. Vernekar","doi":"10.14429/dlsj.8.17920","DOIUrl":"https://doi.org/10.14429/dlsj.8.17920","url":null,"abstract":"A Dye-Sensitised Solar Cell (DSSC) is a low-cost thin film solar cell that works in diffused light and comes in a variety of colors. Most of the investigations on organic dye-based DSSC have used pigments from flowers and fruits as photosensitizers. With the majority of the world's economy reliant on agriculture to meet the food and feed demand, using agricultural resources for color extraction is not a realistic solution. Alternative dye resources, such as microorganisms, must thus be investigated in DSSCs to ensure a long-term future. The present study was a preliminary investigation to explore the potential of carotenoids derived from an actinobacteria Rhodococcus kroppenstedtii as a photosensitizer in a DSSC. The carotenoid extract from R. kroppenstedtii was subjected to stability analysis, to ascertain its potential as a photosensitizer. The extract was found to be stable at varying temperatures (0-80 °C), pH (3-11), and light conditions (dark, white light, sunlight), indicating its potential applicability as a photosensitizer. Further, increasing concentrations (12.5 mg/mL-100 mg/mL) of the extract was used for sensitization of TiO 2 in a DSSC assembly. The extract showed a linear rise in power output (078±0.0001 - 20.75±0.0003 mW), which proposes its scope as a stable and cheap photosensitizer in a DSSC.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135493626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The growing demand for food resources is facing a shortage of supplies subject to the reduction in cultivable land globally, and a dire need for alternative cultivation strategies is the need of the hour.Scientists and researchers throughout the world are focusing onalternative cultivation strategies. However, this kind of cultivation is scarce in developing countries, including India, where the impact is paramount and will woo offthe growing population and reduce cultivable land, as per land census data (2020).Hydroponics isa robust solution forgrowing plants under controlled and regulated cultivation conditions.The term hydroponics means the water at work, which primarily focuses on giving specific nutrientsto support the growth and development of the plant.This opens floodgates for researchers to formulate and optimize novel nutrient growth media.Agricultural output has been duly enhanced with this multifaceted intensive technique.Marketing research data projects that thehydroponics market will be 12,000 million US dollars by 2025.The nutrient solutions are designed to provide all essential macro and micronutrients to plants.The well-aerated media with essential nutrients, crucial organic salts, and balance of ionic concentration, conductivity, and pH, is vitalfor hydroponic culture, a solution to redundant environmental concerns.The current review highlights recent advances in the optimization of hydroponic media compositions.The synergistic effects of a multitude of media on plant growth and product yield have been discussed.
{"title":"Recent Advances in Hydroponic Culture Media Composition and Their Effect on Plant Growth","authors":"Akanksha Aggarwal, Ashwani Mathur","doi":"10.14429/dlsj.8.18024","DOIUrl":"https://doi.org/10.14429/dlsj.8.18024","url":null,"abstract":"The growing demand for food resources is facing a shortage of supplies subject to the reduction in cultivable land globally, and a dire need for alternative cultivation strategies is the need of the hour.Scientists and researchers throughout the world are focusing onalternative cultivation strategies. However, this kind of cultivation is scarce in developing countries, including India, where the impact is paramount and will woo offthe growing population and reduce cultivable land, as per land census data (2020).Hydroponics isa robust solution forgrowing plants under controlled and regulated cultivation conditions.The term hydroponics means the water at work, which primarily focuses on giving specific nutrientsto support the growth and development of the plant.This opens floodgates for researchers to formulate and optimize novel nutrient growth media.Agricultural output has been duly enhanced with this multifaceted intensive technique.Marketing research data projects that thehydroponics market will be 12,000 million US dollars by 2025.The nutrient solutions are designed to provide all essential macro and micronutrients to plants.The well-aerated media with essential nutrients, crucial organic salts, and balance of ionic concentration, conductivity, and pH, is vitalfor hydroponic culture, a solution to redundant environmental concerns.The current review highlights recent advances in the optimization of hydroponic media compositions.The synergistic effects of a multitude of media on plant growth and product yield have been discussed.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135493803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Different types and sources of compost are used to increase agricultural productivity. This review reveals different compost formulation methods and the incorporation of those methods into agriculture to reduce waste production, providing a better way to maintain soil fertility for better plant yield. This review furnishes an in-depth update on the impact of prepared compost from different ingredients like municipal waste, kitchen-based food waste, livestock waste, agricultural waste, algae, and industrial waste to find the effects on soil health, plant growth parameters (height, stem diameter, leaf number, chlorophyll content, etc.), and plant yield. Several studies have shown that compost significantly affects the soil’s health and improves different plants’ morphological (height, width, stem diameter, leaf shape, leaf size, leaf arrangement, root system), physiological (photosynthesis rate, transpiration rate, respiration rate, stomatal conductance, chlorophyll content, carbon dioxide assimilation, nutrient uptake, water use efficiency, flowering time, germination rate), and chemical properties (pH, macronutrient content, micronutrient content, carbohydrate content, protein content, lipid content, phytochemical content, essential oil content, pigment content). Produced compost from different ingredients has significant results for enhancing soil health, nutrient supply to plants, reducing heavy metal accumulation in plants, increasing plant yield, and reducing the environmental pollution. Overall, the results of this study demonstrate the potential of compost formulations made from different waste materials to enhance soil fertility and plant productivity. These findings have important implications for sustainable agriculture and waste management practices. Using compost as a soil amendment can help reduce waste and improve soil health, increasing plant yields and reducing the need for chemical fertilisers. However, the dose of compost prepared from various wastes in different climatic conditions should be optimized at the farm level, with particular emphasis on economic sustainability.
{"title":"Compost Formulation from Different Wastes to Enhance the Soil and Plant Productivity A Review","authors":"Ajay Balda, Arup Giri","doi":"10.14429/dlsj.8.18687","DOIUrl":"https://doi.org/10.14429/dlsj.8.18687","url":null,"abstract":"Different types and sources of compost are used to increase agricultural productivity. This review reveals different compost formulation methods and the incorporation of those methods into agriculture to reduce waste production, providing a better way to maintain soil fertility for better plant yield. This review furnishes an in-depth update on the impact of prepared compost from different ingredients like municipal waste, kitchen-based food waste, livestock waste, agricultural waste, algae, and industrial waste to find the effects on soil health, plant growth parameters (height, stem diameter, leaf number, chlorophyll content, etc.), and plant yield. Several studies have shown that compost significantly affects the soil’s health and improves different plants’ morphological (height, width, stem diameter, leaf shape, leaf size, leaf arrangement, root system), physiological (photosynthesis rate, transpiration rate, respiration rate, stomatal conductance, chlorophyll content, carbon dioxide assimilation, nutrient uptake, water use efficiency, flowering time, germination rate), and chemical properties (pH, macronutrient content, micronutrient content, carbohydrate content, protein content, lipid content, phytochemical content, essential oil content, pigment content). Produced compost from different ingredients has significant results for enhancing soil health, nutrient supply to plants, reducing heavy metal accumulation in plants, increasing plant yield, and reducing the environmental pollution. Overall, the results of this study demonstrate the potential of compost formulations made from different waste materials to enhance soil fertility and plant productivity. These findings have important implications for sustainable agriculture and waste management practices. Using compost as a soil amendment can help reduce waste and improve soil health, increasing plant yields and reducing the need for chemical fertilisers. However, the dose of compost prepared from various wastes in different climatic conditions should be optimized at the farm level, with particular emphasis on economic sustainability.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135493631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The need for novel and useful bioactive secondary metabolites to help and relieve people from all aspects of human conditions is constantly expanding. Every plant tissue has a variety of endophytic fungi, which are thought to be highly effective producers of natural products. In this work, the determination of total phenolics, antioxidants, and L-asparaginase enzyme activity in four fungal endophytes associated with the mangrove plant Acanthus ilicifolius was evaluated. The study indicated that total phenolic content (1633+8.7 μg equivalent to gallic acid) and reducing power (0.96) were the highest for methanolic extracts of the isolate Aspergillus terreus while scavenging activity was highest for the isolate Colletotrichum xishuangbannaense (78.2+4.5 %). The enzyme activity of L-asparaginase was expressed predominantly by all the isolates except Colletotrichum xishuangbannaense. Maximum enzyme activities of 50.1 U/mL, 48.1 U/mL, and 47.7 U/mL were observed in Aspergillus terreus, Colletotrichum cobbiƫense, and Fusarium multiceps respectively. The current research demonstrated that mangrove-associated fungi have a high potential for producing bioactive molecules and L-asparaginase, which can be used as a possible source for the creation of anticancer drugs.
{"title":"Evaluation of in Vitro Antioxidant Activity and L Asparaginase Enzyme Production of Four Endophytic Fungi Isolated from Acanthus Ilicifolius","authors":"Sagar P Shah, Jayaprada Rao Chunduri","doi":"10.14429/dlsj.8.18656","DOIUrl":"https://doi.org/10.14429/dlsj.8.18656","url":null,"abstract":"The need for novel and useful bioactive secondary metabolites to help and relieve people from all aspects of human conditions is constantly expanding. Every plant tissue has a variety of endophytic fungi, which are thought to be highly effective producers of natural products. In this work, the determination of total phenolics, antioxidants, and L-asparaginase enzyme activity in four fungal endophytes associated with the mangrove plant Acanthus ilicifolius was evaluated. The study indicated that total phenolic content (1633+8.7 μg equivalent to gallic acid) and reducing power (0.96) were the highest for methanolic extracts of the isolate Aspergillus terreus while scavenging activity was highest for the isolate Colletotrichum xishuangbannaense (78.2+4.5 %). The enzyme activity of L-asparaginase was expressed predominantly by all the isolates except Colletotrichum xishuangbannaense. Maximum enzyme activities of 50.1 U/mL, 48.1 U/mL, and 47.7 U/mL were observed in Aspergillus terreus, Colletotrichum cobbiƫense, and Fusarium multiceps respectively. The current research demonstrated that mangrove-associated fungi have a high potential for producing bioactive molecules and L-asparaginase, which can be used as a possible source for the creation of anticancer drugs.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135493634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Senescence marker protein 30 (SMP30) is an age-linked marker protein, the expression of which declines with aging. SMP30 binds with calcium; however, the absence of a calcium-binding EF-hand motif makes it different from other calcium-binding proteins like calmodulin. Interestingly, previous studies have shown that it binds with other divalent metal co-factors also and catalyzes the cyclisation of L-gulonate required for the biosynthesis of ascorbate in non-primates. Remarkably, SMP30 is conserved among vertebrates indicating that it isa crucial protein performing certain physiological functions. Apparently, in primates, including humans, calcium homeostasis could be the primary function of SMP30 due to the absence of ascorbic acid biosynthesis in these species. In this review, we have discussed the expression pattern of SMP30 in various cells and tissues. SMP30 expression is modulated by different internal and external factors, which we have extensively discussed here. Subsequently, its role in calcium homeostasis, cell proliferation, apoptosis, and liver regeneration has also been explored. Further, the potentiality of SMP30 as a prophylactic agent against organophosphorus nerve agent poisoning has been elucidated due to its organophosphate hydrolysing activity as a promiscuous substrate.
{"title":"The Multifaceted Role of Senescence Marker Protein 30 in Health and Diseases","authors":"Sudisha Mukherjee, Roshan Kumar Dutta, Rinkoo Devi Gupta","doi":"10.14429/dlsj.8.18117","DOIUrl":"https://doi.org/10.14429/dlsj.8.18117","url":null,"abstract":"Senescence marker protein 30 (SMP30) is an age-linked marker protein, the expression of which declines with aging. SMP30 binds with calcium; however, the absence of a calcium-binding EF-hand motif makes it different from other calcium-binding proteins like calmodulin. Interestingly, previous studies have shown that it binds with other divalent metal co-factors also and catalyzes the cyclisation of L-gulonate required for the biosynthesis of ascorbate in non-primates. Remarkably, SMP30 is conserved among vertebrates indicating that it isa crucial protein performing certain physiological functions. Apparently, in primates, including humans, calcium homeostasis could be the primary function of SMP30 due to the absence of ascorbic acid biosynthesis in these species. In this review, we have discussed the expression pattern of SMP30 in various cells and tissues. SMP30 expression is modulated by different internal and external factors, which we have extensively discussed here. Subsequently, its role in calcium homeostasis, cell proliferation, apoptosis, and liver regeneration has also been explored. Further, the potentiality of SMP30 as a prophylactic agent against organophosphorus nerve agent poisoning has been elucidated due to its organophosphate hydrolysing activity as a promiscuous substrate.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135493628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tsering Dolma, Rohit Kumar, Desyong Namgail, OP Chaurasia, Tsering Stobdan
The length and span of passive solar greenhouse are important factors that determine greenhousemicroclimate. However, there are no established length and span recommendations for guiding construction of passive solar greenhouse in high altitude regions, especially above 3000 m asl. Majority of the farmers in trans- Himalayan regions have preference for low-cost small size (<10 m length) passive solar greenhouses. We studied two different sized greenhouses and found that a large greenhouse (27.4 m length, 8.2 m width) was better than a small greenhouse (9.8 m length, 5.5 m width) for growing cauliflower and cabbage in winter. The large greenhouse remained 1.5±0.3 to 7.4±2.1 °C warmer during daytime, and 0.6±0.1 to 1.5±0.8 °C warmer at night. All the recorded plant growth parameters were higher in the large greenhouse. The mean marketable weight of cauliflower cv. Shantha was 599±35 g in the large greenhouse as against 537±42 g in the small greenhouse. Similarly, the marketable weight of cabbage cv. Golden Acre in the large greenhouse was significantly higher (619±53 g) than the small greenhouse (523±121 g). Therefore, large passive solar greenhouses are recommended for farmers in high altitude trans-Himalayan Ladakh regions.
{"title":"Size of Passive Solar Greenhouse Determine Growth and Yield of Cauliflower and Cabbage During Winter in High Mountain Ladakh Region, India","authors":"Tsering Dolma, Rohit Kumar, Desyong Namgail, OP Chaurasia, Tsering Stobdan","doi":"10.14429/dlsj.8.18450","DOIUrl":"https://doi.org/10.14429/dlsj.8.18450","url":null,"abstract":"The length and span of passive solar greenhouse are important factors that determine greenhousemicroclimate. However, there are no established length and span recommendations for guiding construction of passive solar greenhouse in high altitude regions, especially above 3000 m asl. Majority of the farmers in trans- Himalayan regions have preference for low-cost small size (<10 m length) passive solar greenhouses. We studied two different sized greenhouses and found that a large greenhouse (27.4 m length, 8.2 m width) was better than a small greenhouse (9.8 m length, 5.5 m width) for growing cauliflower and cabbage in winter. The large greenhouse remained 1.5±0.3 to 7.4±2.1 °C warmer during daytime, and 0.6±0.1 to 1.5±0.8 °C warmer at night. All the recorded plant growth parameters were higher in the large greenhouse. The mean marketable weight of cauliflower cv. Shantha was 599±35 g in the large greenhouse as against 537±42 g in the small greenhouse. Similarly, the marketable weight of cabbage cv. Golden Acre in the large greenhouse was significantly higher (619±53 g) than the small greenhouse (523±121 g). Therefore, large passive solar greenhouses are recommended for farmers in high altitude trans-Himalayan Ladakh regions.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135493632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The physicochemical properties of insoluble Prussian blue (PB) play an important role in its thallium binding ability. Therefore, the present study aimed to characterise various physicochemical parameters of PB available commercially and compare them with the USFDA-approved Radiogardase ® -Cs. In addition, PB was synthesised by indirect and direct methods. PB samples and Radiogardase®-Cs were analysed for various parameters like particle size, moisture content, and thermogravimetric analysis (TGA) and correlated with its Maximum Binding Capacity (MBC) for thallium. Radiogardase ® -Cs showed the highest MBC of 238 mg/g for thallium with D 90 of 785 μm and moisture content of 23.24 %. The MBC of other PB samples was found to be significantly lower than Radiogardase ® -Cs which was found to be directly proportional to the moisture content. However, other parameters like particle size, and iron content vary significantly but no correlation was observed with MBC for thallium. This finding suggests that moisture content and MBC are extremely important parameters for optimising the PB to achieve desirable pharmacological efficacy for removing thallium in vivo.
{"title":"Physicochemical Characterisation of Commercially Available Prussian Blue Insoluble Samples and Its Comparison with Radiogardase Cs","authors":"Vivek Kumar, Mahendra Yadav, Kunal Dhankhar, Dharam Pal Pathak, Nidhi Sandal","doi":"10.14429/dlsj.8.18464","DOIUrl":"https://doi.org/10.14429/dlsj.8.18464","url":null,"abstract":"The physicochemical properties of insoluble Prussian blue (PB) play an important role in its thallium binding ability. Therefore, the present study aimed to characterise various physicochemical parameters of PB available commercially and compare them with the USFDA-approved Radiogardase ® -Cs. In addition, PB was synthesised by indirect and direct methods. PB samples and Radiogardase®-Cs were analysed for various parameters like particle size, moisture content, and thermogravimetric analysis (TGA) and correlated with its Maximum Binding Capacity (MBC) for thallium. Radiogardase ® -Cs showed the highest MBC of 238 mg/g for thallium with D 90 of 785 μm and moisture content of 23.24 %. The MBC of other PB samples was found to be significantly lower than Radiogardase ® -Cs which was found to be directly proportional to the moisture content. However, other parameters like particle size, and iron content vary significantly but no correlation was observed with MBC for thallium. This finding suggests that moisture content and MBC are extremely important parameters for optimising the PB to achieve desirable pharmacological efficacy for removing thallium in vivo.","PeriodicalId":36557,"journal":{"name":"Defence Life Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135493635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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