Journal of Feline Medicine and Surgery Open Reports最新文献

Case summary: A 5-year-old female neutered Siberian Forest Cat presented with a 7-day history of lethargy, hyporexia and weight loss. Abdominal ultrasonography revealed bilateral renal changes suggestive of neoplasia. Thoracic radiography documented diffuse pulmonary nodules. The cat was euthanased during diagnostic investigations. Histopathological assessment and immunohistochemical staining of post-mortem renal biopsies were consistent with a histiocytic lesion, most likely histiocytic sarcoma (HS). The lung lesions were suspected of representing disseminated disease.

Relevance and novel information: HS is considered a rare neoplastic process in cats. This report describes a case of feline bilateral renal HS with suspected concomitant pulmonary involvement. A primary renal origin was suspected, with the lung lesions being a result of disseminated disease. Renal HS should be included as a differential diagnosis when renal ultrasonography reveals changes suggestive of neoplasia.

Case summary: This report describes an indoor-only cat with a rare form of sino-orbital aspergillosis (SOA) with cervical lymphadenopathy causing local obstruction. Extensive work-up on initial presentation failed to identify the underlying etiology and the diagnosis was not determined until the disease progressed during a prolonged course of glucocorticoid therapy.

Relevance and novel information: SOA caused by Aspergillus viridinutans complex is increasingly recognized as a significant cause of mortality in cats in recent years, with most cases reported in Australia, Europe and Asia. Feline SOA carries a poor prognosis owing to its invasive nature and resistance to antifungal therapy. This case demonstrates the importance of clinical awareness of SOA as a differential for cats with chronic nasal signs and exophthalmos in the USA. Moreover, it demonstrates a rare form of presentation and potential difficulty in achieving a correct diagnosis.

Case series summary: A 6-week-old intact male domestic shorthair kitten presented for abdominal distension, small stature, vomiting and inappetence. Abdominal radiographs showed marked generalized gaseous gastrointestinal dilation. Exploratory laparotomy revealed type III colonic atresia which was surgically corrected via jejunocolic anastomosis. The kitten survived the immediate postoperative period and was discharged from the hospital but subsequently declined and was euthanized 7 days after surgery.

Relevance and novel information: The patient described in this report is a rare case of colonic atresia diagnosed in the postneonatal period. To our knowledge, this is the first ante-mortem case diagnosed with type III colonic atresia and description of surgical management reported in companion animal medicine. The patient had short-term survival after surgery that, with adjustments to the postoperative care, may result in long-term survival for future patients.

Case series summary: Two castrated male domestic shorthair cats (aged 8 months [case 1] and 13 years [case 2]) were presented at the Small Animal Clinic of the Veterinary Medicine University of Vienna, Austria, both with acute vomiting and distended abdomen, as well as a history of chronic apathy, recurrent vomiting and diarrhoea. Both cats underwent invasive diagnostic procedures approximately 1 month before the diagnosis of sclerosing encapsulating peritonitis (SEP), namely an exploratory laparotomy and a bronchoscopy, respectively. Abdominal ultrasound revealed severely corrugated intestinal loops and, in case 2, the presence of peritoneal effusion. A thick and diffuse fibrous capsule around the intestine was detected and removed surgically, and biopsies were taken from the affected organs confirming the SEP. Case 1 recovered well, was discharged some days after surgery and was clinically unremarkable for the next 2 years. Case 2 showed unsatisfactory improvement directly after surgery and was euthanased a few days later, as the owner declined any further therapy.

Relevance and novel information: SEP is a very rare condition of unclear origins in cats. Here we describe the clinical and diagnostic imaging features, surgical treatment, and outcome of SEP in two cats. The results indicate that prompt diagnosis and appropriate interventions may improve the outcome.

Objectives: In 2019, COVID-19 emerged in China and has since spread worldwide. Owing to the virus's ability to adhere to specific receptors, cats are susceptible to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The popularity of pet cats in Iran has sparked fears of human-cat-human transmission of the virus. This study aimed to identify positive cases in cats owned by people infected with SARS-CoV-2, to determine if they remained positive for >3 weeks and to examine the virus genome isolated from a number of cats and one of their owners.

Methods: A total of 30 cats were sampled approximately 3 days after their owners tested positive (day 1), and 3 weeks later, in strict accordance with health regulations. Rectal and oropharyngeal samples were collected. All samples were subjected to a qualitative PCR and reverse transcription PCR. The S-gene region was partially sequenced in positive samples and the results were used to create a phylogenetic tree.

Results: SARS-CoV-2 was detected in 7/30 (23.3%) cats examined. In the third week, every cat tested negative. The sequence data of positive cats and one of their owners revealed that the retrieved RNAs belonged to the alpha variation. The genetic distance between the samples and the reference sequence (20I/B.1.1.7: OM003849, MZ344997) was minimal, with a 99% similarity. Positive samples of cats had four mutations in gene S. Amino acid substitutions in the spike glycoprotein at positions N501Y, A570D, D614G and P681H were recorded in the isolates compared with 780 other sequences of Iranian strains.

Conclusions and relevance: This study confirmed the presence of SARS-CoV-2-infected cats living in close contact with infected owners. Despite cats' susceptibility to COVID-19, the risk of severe infection in these animals is low, as evidenced by the lack of clinical signs in positive cats.

Case series summary: A 1-year-old castrated male Maine Coon cat was referred because of a 1-week history of progressive spastic non-ambulatory paraparesis. An MRI examination of the thoracolumbar spine showed multiple lytic lesions, with the most aggressive one centred on the adjacent endplates of L1-L2 and its associated disc. Ventral new bone formation, L1 vertebral body shortening and mild dorsal displacement of the caudal aspect of L1 were noted. Contrast enhancement of both paravertebral soft tissue and extradural lesion was present. These findings were compatible with L1-L2 discospondylitis (DS), spinal epidural empyema (SEE), with secondary L1 pathological vertebral fracture, subluxation and spinal cord compression. CT of the thoracolumbar spine, abdomen and thorax confirmed these findings. The patient deteriorated to paraplegia with absent nociception, despite initial medical therapy. A right-sided L1-L2 hemilaminectomy and spinal decompression were then performed, followed by application of a unilateral construct comprising four smooth arthrodesis wires and polymethylmethacrylate (PMMA). Staphylococcus aureus was isolated from both epidural material, intraoperatively sampled and blood culture. Antibiotic therapy was continued for 6 weeks, based on susceptibility results. The outcome was excellent, with a gradual improvement and complete neurological recovery at the 8-week postoperative check. Repeated spinal radiographs showed an intact apparatus and marked signs of vertebral fusion. At the 14-month follow-up examination, the cat remained free of clinical signs.

Relevance and novel information: To the authors' knowledge, this is the first case report of SEE and DS in a cat that required surgical stabilisation. The outcome was still optimal, despite the rapid neurological deterioration.

Case series summary: Three cats (five stifles) were diagnosed with varying degrees of pelvic limb lameness secondary to medial patellar luxations (MPLs). Lameness did not resolve with medical management in any cat before referral for orthopedic evaluation. All cats underwent semi-cylindrical recession trochleoplasty (SCRT), medial fascial release and lateral imbrication for surgical repair of MPLs. All cats were re-evaluated at 3 and 8 weeks postoperatively and two cats were also evaluated at 16 weeks postoperatively. At the final rechecks, all cats had resolution of lameness of the operated limb(s) and no evidence of recurrence of patellar luxation.

Relevance and novel information: This case series demonstrated SCRT with soft tissue reconstruction as an acceptable option for surgical correction in three cats with MPLs. Short-term outcomes revealed minor complications and all patellae remained centralized.

Case summary: A 12-year-old male neutered domestic shorthair cat presented with a 2-week history of serous unilateral nasal discharge, swelling of the nasal bridge and sneezing. Whole-body CT revealed a mass filling the entire right nasal cavity with lysis of the cribriform plate. The cat was diagnosed with sinonasal large-cell lymphoma based on cytopathological analysis, with PCR-based lymphocyte clonality testing showing a monoclonal population with rearrangement of the immunoglobulin heavy chain gene. The cat received radiotherapy with a dose of 30 Gy in seven fractions given three times weekly, and then cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP)-based chemotherapy was initiated soon after completion of the radiotherapy schedule. Despite this treatment, CT performed 4 months after radiotherapy revealed enlargement of the lesion in the right nasal cavity consistent with presumed progression of the cat's lymphoma. The cat then received rescue chemotherapy with chlorambucil, which markedly reduced the size of the disease burden in the nasal and frontal sinus without severe adverse effects. At the time of writing, the cat was receiving chlorambucil for 7 months without any clinical signs suggestive of tumour relapse.

Relevance and novel information: To our knowledge, this is the first case of feline sinonasal lymphoma with chlorambucil used as rescue chemotherapy. This case indicates that chemotherapy with chlorambucil may be a useful treatment option for cats with relapsing sinonasal lymphoma following radiotherapy and/or CHOP-based chemotherapy.