Journal of Feline Medicine and Surgery Open Reports最新文献

Objectives: The objective of this study was to retrospectively assess the pathogens associated with feline ocular and respiratory diseases in routine diagnostic samples submitted to Georgia Veterinary Diagnostic Laboratories. Furthermore, pathogens detected by the respiratory PCR panel in the upper vs lower respiratory tract were compared (specimen separation at pharynx).

Methods: Test records from feline ocular and respiratory PCR panels were collected from 2012 to 2022. While the ocular panel targets feline herpesvirus-1 (FHV), feline calicivirus (FCV) and Chlamydia felis, the respiratory panel covers FHV, FCV, C felis, Mycoplasma species, Bordetella bronchiseptica and influenza A virus.

Results: In total, 120 and 453 submissions were made for the ocular and respiratory panels, with positivity rates of 49.2% (59/120) and 69.3% (314/453), respectively. Based on the available signalment, cats aged younger than 3 years made up 59.3% (32/54) and 47.3% (130/275) of positive cases, respectively. The top two findings by ocular and respiratory panels were single detection of FCV (28.8%, 17/59), FHV (25.4%, 15/59) and Mycoplasma species (36.9%, 116/314), co-detection of FCV + Mycoplasma species (20.4%, 64/314), respectively. The most common detection from samples of upper vs lower respiratory tract was Mycoplasma species (39.6%, 97/245) and FCV + Mycoplasma species (25%, 10/40).

Relevance and novel information: FCV and FHV were the most frequent detections by the ocular panel, with Mycoplasma species and FCV + Mycoplasma species being the most frequent detections by the respiratory panel. Incorporating FCV and FHV in the vaccination regimen could help reduce the cases of feline ocular and respiratory diseases, especially for cats aged younger than 3 years. Veterinarians should consider Mycoplasma species when dealing with feline respiratory infections.

Case summary: A 7-year-old female spayed domestic shorthair cat was presented to our hospital with a 2-day history of anorexia, dyspnoea and lethargy. Blood tests revealed mild anaemia (packed cell volume [PCV] 22.4%) and the biochemistry panel was unremarkable. Thoracic radiographs and echocardiography showed the presence of pericardial effusion with cardiac tamponade as well as pleural effusion. During the initial attempt at pericardiocentesis, a small sample was obtained, sufficient only for fluid analysis and cytology. Subsequently, the pericardial effusion immediately resolved, presumably owing to the drainage of pericardial fluid into the pleural space. Thoracocentesis was then performed, yielding 50 ml of fluid. The analysis of the fluid was consistent with a protein-rich transudate associated with macrophagic-neutrophilic inflammation in both sampled areas. PCR was positive for Bartonella henselae in the pleural/pericardial fluid pool and peripheral blood. Bacterial culture was negative and feline coronavirus real-time PCR was negative. The patient was treated with marbofloxacin 5 mg/kg PO q24h for 5 weeks. No clinical signs were reported at this time; however, blood B henselae PCR remained positive. Treatment was changed to doxycycline at 5 mg/kg PO q12h for 6 weeks. The cat remained subclinical throughout the treatment, and a blood PCR after 6 weeks yielded negative results.

Relevance and novel information:  To the best of the authors' knowledge, the present clinical findings related to B henselae infection in a cat without concurrent heart failure have not been previously documented. This clinical case highlights the need to include Bartonella species as a differential diagnosis in cats with protein-rich transudate effusions associated with neutrophilic-macrophagic inflammation and fever.

Case summary: A 5-year-old female spayed domestic shorthair cat presented for sudden onset vision loss 3 days after a dental procedure. Bilateral blindness was confirmed on ocular examination, with fundoscopy revealing segmental wedge-shaped areas of retinal oedema and partial non-rhegmatogenous retinal detachments. An initial differential diagnosis included angioinvasive pulmonary carcinoma, based on previously reported fundoscopy images of this condition; however, general physical examination, blood pressure and chest radiographs were all normal. Four weeks after initial presentation, fundoscopy revealed the resolution of the retinal detachments; however, bilateral segmental chorioretinal necrosis was present. The cat regained some vision and remained well 13 months after the initial presentation. Considering the clinical findings, the onset of blindness after a lengthy dental procedure and improvement of vision over time, a diagnosis of pulmonary carcinoma was unlikely and instead a diagnosis of chorioretinal ischaemia secondary to maxillary artery blood flow restriction is proposed.

Relevance and novel information: Maxillary artery blood flow restriction has been well documented with varying degrees of jaw opening in cats. Presumed central blindness as a result of this blood flow restriction has also been documented. However, to the authors' knowledge, vision loss due to retinal changes, documented by fundoscopic images and their progression over time following suspected chorioretinal ischaemia after a dental procedure, have not previously been reported. We propose that temporary occlusion of the maxillary artery can result in segmental chorioretinal necrosis and associated blindness in cats. This finding further supports the recommendation to minimise prolonged jaw opening during surgical procedures in cats.

[This corrects the article DOI: 10.1177/20551169231213499.].

Case summary: A 2-year-old female spayed domestic shorthair cat was presented for evaluation of severe thickening of the proximal duodenum identified on abdominal ultrasound after a 1-year history of vomiting. At surgery, a proximal duodenal mass encompassed the areas of the major and minor duodenal papillae. A gastrojejunostomy was performed to bypass the proximal duodenum and maintain the integrity of the major duodenal papilla. Histopathology revealed changes consistent with feline eosinophilic sclerosing fibroplasia. The cat was treated with prednisolone and survived for 2.5 years. It was euthanized for bronchopneumonia.

Relevance and novel information: This case report describes a surgical approach for cats with lesions involving the pylorus and proximal duodenum. Gastrojejunostomy provided a therapeutic option that preserved exocrine pancreatic and biliary secretion in this cat.

Case summary: A 12-year-old male castrated domestic shorthair cat exhibited right Horner's syndrome, right facial nerve paresis, difficulty swallowing, coughing, gait abnormalities and weight loss. Despite prior unspecific treatment by a primary care veterinarian with cortisone and antibiotics, the cat's condition worsened, culminating in tetraparesis and right hemispasms. Imaging studies, including CT and MRI, identified a mass extending from the carotid body into the neurocranium, causing displacement of adjacent brain structures and meningeal contrast uptake. Histopathology confirmed a malignant B-cell lymphoma. Differential diagnoses are explored, with a particular focus on carotid body tumours, which originate from the chief cells of the carotid body. These neoplasias are rare in non-human primates, dogs, cats and horses, possibly influenced by genetic predisposition and environmental factors such as hypoxia.

Relevance and novel information: Carotid body tumours are rare in cats, as they are in other animal species. Although lymphomas are the most common feline neoplasms, to our knowledge, no previous case of a B-cell lymphoma in the carotid body has been described in the feline species to date. This case underscores the importance of considering rare and common neoplastic entities in feline patients with atypical clinical presentations and locations. Thereby highlighting the diagnostic challenges in veterinary oncology.

Case summary: This report describes a case of gastric mucormycosis in a young Ragdoll cat with a 5-day history of vomiting. Physical examination detected mild dehydration and tenderness was elicited on abdominal palpation. The results of blood work-up and radiographic study were unremarkable; however, abdominal ultrasonographic examination revealed multiple hyperechoic neoformations at the level of the pyloric antrum, which were confirmed on endoscopic examination. Non-septate hyphae of irregular diameter with a branched appearance were observed on cytology, and histological examination revealed severe diffuse necrotising and granulomatous gastritis with the presence of intralesional fungal hyphae indicative of mucormycosis, which was confirmed by PCR tests. Antifungal therapy with ketoconazole in addition to supportive treatment temporarily improved the clinical condition. Lethargy, fever and abdominal effusion developed in the following days. Cytological examination of abdominal fluid was compatible with septic peritonitis and, given the severity of the condition, euthanasia was opted by the owners. Post-mortem examination confirmed septic peritonitis resulting from perforation of the gastric wall at one of the neoformations of the pyloric antrum.

Relevance and novel information: To the authors' knowledge, this is the first reported case of gastric mucormycosis in a cat. Previous literature includes a case of mucormycosis in a Persian cat affecting only the duodenum. In both the Persian cat and the cat described here, gastrointestinal mucormycosis disease progressed rapidly and was fatal.

Case summary: A 9-year-old male castrated domestic shorthair cat from northern California was evaluated for a 12-month history of dermal and subcutaneous dermatitis in the inguinal region. Histopathologic examination of a biopsy revealed severe, chronic, multifocal to coalescing pyogranulomatous dermatitis and panniculitis, accompanied by ulceration and central necrosis. Aerobic bacterial culture of lesions yielded mycobacterial growth. Empiric antimicrobial therapy was initiated with doxycycline and marbofloxacin pending culture and susceptibility. Culture of a biopsy followed by rpoB gene sequencing at a mycobacterial reference laboratory yielded Mycobacterium porcinum after 6 weeks. Ten months after initial antimicrobial administration, the lesions resolved.

Relevance and novel information: To date, in cats, M porcinum panniculitis has been reported from Ohio, Massachusetts and British Columbia in North America; two additional cases were reported from southeastern Australia. In humans, M porcinum infections have been reported from several states in the USA, predominantly in the Midwest and coastal south, but not from the west. This report extends the known spatial distribution of M porcinum to the western USA and strengthens its association with panniculitis in cats. It also demonstrates the need for prolonged incubation for diagnosis of some rapidly growing mycobacteria infections using culture.

Case summary: A 13-year-old male castrated domestic shorthair cat presented with a 2-month history of progressive lameness, poor appetite and constipation. Physical examination revealed palpable lesions in muscles of several extremities. Ultrasound examination confirmed the presence of round lesions with a hypo- or anechoic centre within the muscles. These lesions were characterised by an anechoic, occasionally trabeculated, central area surrounded by a hyperechoic band with heterogeneous echotexture. In total, seven lesions affecting six appendicular muscles were detected in different evolution stages, as suggested by their sizes and ultrasonographic features. Fine-needle aspiration of the muscle lesions revealed nests and isolated pleomorphic large neoplastic cells consistent with a carcinoma (vs sarcoma) and one mass was surgically removed. The histological and immunohistochemical studies confirmed a diagnosis of metastatic urothelial carcinoma. Although this neoplasia typically originates from the urothelium of the urinary bladder or renal pelvis, the primary tumour could not be detected in repeated abdominal ultrasound examinations. The cat was euthanased and further evaluations were declined by the author.

Relevance and novel information: Urothelial carcinoma is a rare and highly aggressive neoplasia in the cat. While metastasis to regional lymph nodes and lungs are common in cats and dogs, to the authors' knowledge, there have been no reports of metastasis to multiple appendicular muscles in cats. This clinical presentation should be considered in the differential diagnoses of multiple nodular or cystic lesions affecting long muscles in cats.