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Traumatic Brain Injury among Native Hawaiian and Pacific Islander Veterans accessing Veterans Health Administration Homeless Services: A Preliminary Examination. 获得退伍军人健康管理局无家可归服务的夏威夷土著和太平洋岛民退伍军人的创伤性脑损伤:初步检查。
Q4 Medicine Pub Date : 2026-03-11 eCollection Date: 2026-01-01 DOI: 10.62547/UNTK4831
Ryan Holliday, Sara Lum, Christine Kindler, Shiloh E Jordan, Darrin Aase, Gayle Y Iwamasa, Shawn Liu, Jack Tsai, Lauren E Molella, Lindsey L Monteith

Veterans experiencing homelessness have elevated rates of traumatic brain injury (TBI) diagnoses. There remains limited research on subsets of homeless Veterans, including Native Hawaiian and Pacific Islander (NHPI) Veterans. Department of Veterans Affairs (VA) electronic medical records of 724 752 Veterans who accessed Veterans Health Administration (VHA) homeless services from January 2005-December 2018 were examined. Of the total sample, 1177 identified as NHPI, with comparator samples of non-NHPI (n=723 575) and White (n=418 085) Veterans also generated. Rates of TBI were compared between NHPI Veterans relative to non-NHPI Veterans, as well as between NHPI and White Veterans (a subset of the non-NHPI Veteran sample). NHPI homeless Veterans were more likely to have a documented TBI diagnosis relative to non-NHPI homeless Veterans (AOR=1.82, 95% CI: 1.57-2.11), including the White homeless Veteran subgroup specifically (AOR=1.51, 95% CI: 1.30-1.75). This persisted in the presence of several covariates, including sex, ethnicity, rurality, VA service-connected disability, posttraumatic stress disorder, depression, and VHA mental health and general service use. NHPI homeless Veterans were also significantly less likely to utilize VHA services, suggesting an important gap in health service delivery. Results support potentially heightened risk for TBI among NHPI homeless Veterans, and a need to elucidate if such injuries occur during or outside of military service. Alternatively, given potential sociocultural differences, understanding the experience and expression of TBI sequelae among NHPI homeless Veterans is essential. Further research is requisite to understand how to optimally engage homeless NHPI Veterans in care to ensure TBI-related sequelae are adequately identified and addressed.

经历过无家可归的退伍军人的创伤性脑损伤(TBI)诊断率较高。对无家可归的退伍军人的子集,包括夏威夷原住民和太平洋岛民(NHPI)退伍军人的研究仍然有限。对2005年1月至2018年12月期间使用退伍军人健康管理局(VHA)无家可归服务的724 752名退伍军人的退伍军人事务部(VA)电子病历进行了检查。在总样本中,有1177人被确定为NHPI,并产生了非NHPI (n=723 575)和White (n=418 085)退伍军人的比较样本。比较了NHPI退伍军人与非NHPI退伍军人之间以及NHPI退伍军人与白人退伍军人(非NHPI退伍军人样本的一个子集)之间的TBI发生率。与非NHPI无家可归的退伍军人相比,NHPI无家可归的退伍军人更有可能有记录在案的TBI诊断(AOR=1.82, 95% CI: 1.57-2.11),特别是白人无家可归的退伍军人亚组(AOR=1.51, 95% CI: 1.30-1.75)。在一些协变量的存在下,包括性别、种族、农村、退伍军人管理局服务相关的残疾、创伤后应激障碍、抑郁症、退伍军人管理局心理健康和一般服务使用情况,这种情况仍然存在。国家卫生保健计划无家可归的退伍军人也明显不太可能利用VHA服务,这表明在卫生服务提供方面存在重大差距。结果支持在NHPI无家可归的退伍军人中发生TBI的潜在风险增加,并且需要阐明这种伤害是否发生在服兵役期间或以外。另外,考虑到潜在的社会文化差异,了解NHPI无家可归退伍军人的TBI后遗症的经历和表达是必不可少的。进一步的研究是必要的,以了解如何最佳地参与无家可归的NHPI退伍军人的护理,以确保充分识别和解决创伤性脑损伤相关的后遗症。
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引用次数: 0
Deficiencies in the Assessment of Penicillin Allergy in Hospitalized Children in Hawai'i, 2021-2023. 2021-2023年夏威夷住院儿童青霉素过敏评估的不足
Q4 Medicine Pub Date : 2026-03-03 eCollection Date: 2026-01-01 DOI: 10.62547/VTHZ6595
Thanaporn Ratchataswan, Rodolfo E Bégué

Although claims of penicillin allergy are common, after evaluation they are seldom confirmed and can lead to unnecessary interventions. National recommendations are to thoroughly evaluate potential allergies and, if appropriate, to delabel. This retrospective study reviewed records of children hospitalized at Kapi'olani Medical Center for Women and Children in Honolulu, Hawai'i, between January 1, 2021 and June 30, 2023 to assess the frequency of penicillin allergy claims, the appropriateness of their evaluation, and initiation of interventions. Of 3484 hospitalized children, 97 (2.8%) reported penicillin allergy. Documentation, by the admitting team, of the nature of allergy was incomplete for most (97%) of the hospitalizations, leading to deficient risk stratification, lack of implementation of recommended interventions, and frequent use of second-line antibiotics in 46.8% of those who required antibiotic treatment. While this problem is not unique to Hawai'i, it emphasizes the need for education among local providers to improve outcomes.

虽然青霉素过敏的说法很常见,但经评估后很少得到证实,并可能导致不必要的干预。国家的建议是彻底评估潜在的过敏,如果合适的话,去掉标签。本回顾性研究回顾了2021年1月1日至2023年6月30日期间在夏威夷檀香山Kapi'olani妇幼医疗中心住院的儿童的记录,以评估青霉素过敏索赔的频率、评估的适当性和干预措施的启动。在3484名住院儿童中,97名(2.8%)报告青霉素过敏。入院团队对大多数(97%)住院患者过敏性质的记录不完整,导致风险分层不足,缺乏推荐干预措施的实施,46.8%需要抗生素治疗的患者频繁使用二线抗生素。虽然这个问题并不是夏威夷独有的,但它强调了在当地提供教育以改善结果的必要性。
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引用次数: 0
Prevalence of Vitamin D Deficiency in Military Dependent Infants in Hawai'i. 夏威夷军人依赖性婴儿维生素D缺乏症的患病率。
Q4 Medicine Pub Date : 2026-03-03 eCollection Date: 2026-01-01 DOI: 10.62547/WKYZ3476
Morgan F Smith, Brandon L Rozanski, Claire P Witmer, Dolores Mullikin, Sebastian K Welsh

This study aimed to determine the prevalence of vitamin D deficiency and insufficiency among military dependent infants in the state of Hawai'i. A cross-sectional study was conducted at Tripler Army Medical Center and included samples from 30 healthy, full-term infants around 4 months of age. Serum 25-hydroxyvitamin D levels were measured, and caregivers completed questionnaires about the infant's diet, vitamin D supplementation, race/ethnicity, and military sponsor pay grade. Results revealed that 90% of infants had sufficient vitamin D levels (>20 ng/mL), with 3% deficient and 7% insufficient. The prevalence of deficiency and insufficiency was comparable to studies conducted in other regions of the United States. This is the first study to investigate infant vitamin D status in Hawai'i using serum 25-hydroxyvitamin D. Vitamin D status varied significantly by race/ethnicity. The average vitamin D level of Black or African American infants was in the insufficient range and was significantly lower than that observed in White/Caucasian and Hispanic infants. Notably, several exclusively breastfed infants who did not receive vitamin D supplementation had sufficient vitamin D levels. While study limitations include a small sample size and cross-sectional design, the findings warrant continued investigation into the prevalence of vitamin D deficiency and insufficiency among military dependent infants in Hawai'i. Future research should explore the influence of race/ethnicity and socioeconomic status on infant vitamin D levels in Hawai'i and consider the impact of maternal vitamin D status, especially in exclusively breastfed infants. This could lead to more targeted vitamin D supplementation recommendations in clinical practice and potentially improve resource allocation.

本研究旨在确定维生素D缺乏症和不足的患病率在军事依赖婴儿在夏威夷州。在特里普勒陆军医学中心进行了一项横断面研究,其中包括30名大约4个月大的健康足月婴儿的样本。测量了血清25-羟基维生素D水平,护理人员完成了关于婴儿饮食、维生素D补充、种族/民族和军事赞助者工资等级的问卷调查。结果显示,90%的婴儿有足够的维生素D水平(20毫微克/毫升),3%缺乏,7%不足。缺乏和不足的患病率与在美国其他地区进行的研究相当。这是第一项利用血清25-羟基维生素D调查夏威夷婴儿维生素D状况的研究。维生素D状况因种族/民族而有显著差异。黑人或非裔美国婴儿的平均维生素D水平处于不足的范围,明显低于白人/高加索和西班牙裔婴儿。值得注意的是,一些完全母乳喂养的婴儿没有补充维生素D,他们的维生素D水平足够。虽然研究的局限性包括样本量小和横断面设计,但研究结果值得继续调查夏威夷军人抚养婴儿中维生素D缺乏症和不足的患病率。未来的研究应探讨种族/民族和社会经济地位对夏威夷婴儿维生素D水平的影响,并考虑母亲维生素D状况的影响,特别是对纯母乳喂养的婴儿。这可能会在临床实践中提出更有针对性的维生素D补充建议,并可能改善资源分配。
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引用次数: 0
What Is Known about Substance Use in Hawai'i: A Scoping Review. 什么是已知的物质使用在夏威夷:一个范围审查。
Q4 Medicine Pub Date : 2026-02-03 eCollection Date: 2026-01-01 DOI: 10.62547/WCXS6948
Seunghye Hong, Constance Emory-Khenmy, Austin Ajimura, Gwen Williams

Substance use is a significant public health and social welfare issue in the state of Hawai'i. Literature and data about the most affected populations and geographies in Hawai'i are scattered. A scoping review was conducted to assess the extent of available information about substance use in Hawai'i. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Reviews (PRISMA-ScR) Checklist was used as a guide, using 3 databases: PubMed, Web of Science, and CINAHL for publication years 2010-2023. A manual search was conducted to identify other reports. A total of 21 documents were included in the synthesis. The synthesis revealed a large focus on substance use among Native Hawaiians and adolescents. The granularity of geographical data was found to be at island-level and the 3 most common substances reported were alcohol, marijuana, and methamphetamine. There were data for a wide range of racial and ethnic groups, which is unique due to the diversity in the state of Hawai'i. Most documents used national datasets for reporting substance use in Hawai'i. The findings identified gaps in the literature that can be filled by future research such as focusing on the rise of substance use among older adults, disaggregating data on Pacific Islander populations in Hawai'i, reporting substance use data in geographical areas smaller than island-level, increasing the collection of data on groups that have a high risk for health problems or are underserved by health services, and intensifying collection of data about fentanyl use in Hawai'i.

在夏威夷州,药物使用是一个重大的公共卫生和社会福利问题。关于夏威夷受影响最严重的人口和地理位置的文献和数据是分散的。进行了范围审查,以评估关于夏威夷物质使用的现有信息的程度。使用2010-2023年出版年份的3个数据库:PubMed、Web of Science和CINAHL,以系统评价和荟萃分析范围评价首选报告项目(PRISMA-ScR)清单为指南。进行了手动搜索以确定其他报告。综合报告共包括21份文件。这项综合研究揭示了夏威夷原住民和青少年对药物使用的大量关注。发现地理数据的粒度在岛屿一级,报告的三种最常见的物质是酒精、大麻和甲基苯丙胺。有广泛的种族和族裔群体的数据,由于夏威夷州的多样性,这是独一无二的。大多数文件使用国家数据集来报告夏威夷的物质使用情况。调查结果确定了文献中的空白,这些空白可以通过未来的研究来填补,例如关注老年人药物使用的增加,对夏威夷太平洋岛民人口的数据进行分类,报告小于岛屿水平的地理区域的药物使用数据,增加对健康问题高风险群体或卫生服务不足群体的数据收集,以及加强对夏威夷芬太尼使用数据的收集。
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引用次数: 0
A Place to Belong: How Ibasho Is Redefining Aging in Hawai'i. 一个归属的地方:伊巴肖如何重新定义夏威夷的老龄化。
Q4 Medicine Pub Date : 2026-02-03 eCollection Date: 2026-01-01 DOI: 10.62547/XNMI1937
Emi Kiyota, Margaret A Perkinson, Clementina Ceria-Ulep
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引用次数: 0
What Do We Know About the Use of Oral Nicotine Pouches? A Scoping Review of Quantitative Studies. 我们对口服尼古丁袋的使用了解多少?定量研究的范围综述。
Q4 Medicine Pub Date : 2026-02-03 eCollection Date: 2026-01-01 DOI: 10.62547/NOLD3340
Samia Amin, Kristina T Phillips, Michael M Phillips, S Lani Park, Pallav Pokhrel

Oral nicotine pouches (ONPs) represent a rapidly emerging nicotine product. Little is known about the current state of quantitative research regarding patterns of ONP use; perceptions and motives related to ONP use; adverse consequences of ONP use; and use of ONPs relative to other tobacco products. To address this gap, this review aimed to summarize the findings of published, population-based research on ONPs. A comprehensive search of electronic databases (PubMed, Scopus, Web of Science, and Google Scholar) was conducted in March 2024 to identify relevant studies on ONP use. A narrative synthesis of the findings was performed. A total of 11 studies were identified including experimental (n=3), cross-sectional (n=7), or intervention-based (n=1). Nine to 10% of adolescents and young adults report ever using ONPs. ONP use is most common among young people who also currently smoke cigarettes or use electronic-cigarettes (e-cigarettes). Marketing messages centered around flavors and social facilitation appear to resonate with young people and experiencing pleasant flavors appears to a key motive for ONP use. Immediate adverse consequences of ONP use appear to be mild. Some evidence suggests that ONPs may be appealing as a reduced-harm alternative for habitual smokers. Evidence regarding ONP use patterns among adolescents and adults appears to be lacking. More longitudinal studies are needed to better understand the antecedents and consequences of ONP use. In addition, more studies are needed to compare the health effects of ONP vs. e-cigarettes and to better understand the dynamics of exclusive and dual use of e-cigarettes and ONP.

口服尼古丁袋(ONPs)是一种新兴的尼古丁产品。关于ONP使用模式的定量研究的现状知之甚少;与ONP使用有关的认知和动机;使用ONP的不良后果;以及与其他烟草制品相比非烟草产品的使用情况。为了解决这一差距,本综述旨在总结已发表的基于人群的onp研究结果。我们于2024年3月对PubMed、Scopus、Web of Science和b谷歌Scholar等电子数据库进行了全面检索,以确定有关ONP使用的相关研究。对调查结果进行了叙述综合。共纳入11项研究,包括实验性研究(n=3)、横断面研究(n=7)和基于干预的研究(n=1)。9%到10%的青少年和年轻人报告曾经使用过onp。ONP的使用在目前吸烟或使用电子烟(电子烟)的年轻人中最为常见。以口味和社交便利为中心的营销信息似乎与年轻人产生了共鸣,体验宜人的口味似乎是使用ONP的关键动机。使用ONP的直接不良后果似乎是轻微的。一些证据表明,对于习惯吸烟者来说,onp可能是一种降低危害的替代品。关于青少年和成人使用ONP模式的证据似乎缺乏。需要更多的纵向研究来更好地了解ONP使用的前因后果。此外,需要更多的研究来比较ONP与电子烟的健康影响,并更好地了解电子烟和ONP的单独和双重使用的动态。
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引用次数: 0
Bioinformatics Research at University of Hawai'i: an Overview and Undergraduate Student Perspective. 夏威夷大学生物信息学研究:概述与本科生视角。
Q4 Medicine Pub Date : 2026-01-05 eCollection Date: 2026-01-01 DOI: 10.62547/PVZI7945
Micaiah Cape
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引用次数: 0
Monitoring Public Health During the 2023 Maui Wildfire Using Google Search Trends. 利用谷歌搜索趋势监测2023年毛伊岛野火期间的公共卫生状况。
Q4 Medicine Pub Date : 2026-01-03 eCollection Date: 2026-01-01 DOI: 10.62547/QCKY9141
Jim P Stimpson, Ketan Tamirisa, Joseph Keaweʻaimoku Kaholokula, Alexander N Ortega

Wildfires pose acute and long-term threats to public health. This study used Google Trends to assess real-time public interest in health-related topics before, during and after the August 2023 Maui wildfires. Search terms were grouped into four categories: health care access, physical health, mental health, and help-seeking behavior. Daily search interest scores were aggregated and analyzed across three periods: pre-wildfire, wildfire, and post-wildfire. Findings revealed that physical health and health care access search interest remained relatively stable throughout the study period, with no measurable surge during or after the wildfire event. This lack of increase may reflect reliance on pre-established care plans among individuals with chronic respiratory conditions, in-person care-seeking, or prioritization of immediate safety over online information-seeking. In contrast, mental health-related searches rose substantially in the weeks following the wildfire, while help-seeking searches showed episodic fluctuations with notable peaks post-disaster. These findings illustrate how online search patterns can reveal evolving public health priorities in the wake of disasters. Google Trends offers a timely and scalable tool to monitor evolving health concerns during disasters, complementing traditional surveillance systems. Integrating search data into disaster response planning could enhance resource allocation, guide communication strategies, and ensure timely support for emerging needs, particularly mental health recovery following wildfire events.

野火对公众健康构成严重和长期的威胁。本研究使用谷歌Trends来评估2023年8月毛伊岛野火之前、期间和之后公众对健康相关主题的实时兴趣。搜索词被分为四类:医疗保健、身体健康、心理健康和寻求帮助的行为。每日搜索兴趣得分被汇总并分析了三个时期:野火前、野火后和野火后。研究结果显示,在整个研究期间,身体健康和医疗保健获取搜索兴趣保持相对稳定,在野火事件期间或之后没有可测量的激增。这种缺乏增长可能反映了慢性呼吸道疾病患者对预先制定的护理计划的依赖,亲自寻求护理,或者优先考虑即时安全而不是在线信息寻求。相比之下,与精神健康相关的搜索量在野火发生后的几周内大幅上升,而寻求帮助的搜索量则出现了间歇性波动,在灾后达到了显著的峰值。这些发现说明了在线搜索模式如何揭示灾难发生后不断变化的公共卫生优先事项。谷歌Trends提供了一个及时和可扩展的工具,用于监测灾害期间不断变化的卫生问题,补充了传统的监测系统。将搜索数据纳入救灾规划可以加强资源分配,指导沟通战略,并确保及时支持新出现的需求,特别是野火事件后的心理健康恢复。
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引用次数: 0
Historical Review of Acute Myocardial Ischemia Risk Assessment. 急性心肌缺血风险评估的历史回顾。
Q4 Medicine Pub Date : 2026-01-01 DOI: 10.62547/JMJM6124
Jerris R Hedges, W Brian Gibler, Gary P Young

The specialty of emergency medicine has emphasized the importance of the rapid diagnosis and treatment of time-dependent conditions. Recognition of the emergency patient at high risk for myocardial ischemia is one such condition. In collaboration with cardiologists and laboratory medicine specialists, emergency physicians have revolutionized the approach to diagnosing patients at risk for myocardial ischemia in the emergency department. This article provides a historical viewpoint based upon the authors' practice and research in myocardial ischemia risk recognition beginning in the 1980s, along with the work of selected researchers in the field to describe an evolving understanding of the underlying pathophysiology, the application of serial laboratory diagnostic techniques, and resultant goal-directed multidisciplinary care of the at-risk patient. Such an approach lends itself to the clinical assessment of patients in a multicultural, multiethnic environment as seen in Hawai'i. The evolution of acute myocardial ischemia risk assessment through emergency medicine research is detailed, including (a) the recognition of the limitations of patient discomfort subjective language descriptors, (b) the incorporation of highly specific and sensitive laboratory biomarkers for MI, and (c) the use of mechanistically-driven, serial clinical and laboratory assessments. Today's objective emergency approach to acute myocardial ischemia risk assessment is relevant to cross-cultural applications, as is required for medical care in the Pacific Basin.

急诊医学专业强调了快速诊断和治疗时间依赖性疾病的重要性。对心肌缺血高危急诊患者的识别就是这样一种情况。急诊医师与心脏病专家和实验室医学专家合作,彻底改变了急诊科诊断有心肌缺血风险患者的方法。本文基于作者自20世纪80年代开始在心肌缺血风险识别方面的实践和研究,以及该领域选定的研究人员的工作,提供了一个历史观点,以描述对潜在病理生理学的不断发展的理解,一系列实验室诊断技术的应用,以及对高危患者的目标导向的多学科护理。这种方法适用于夏威夷多文化、多民族环境下对患者的临床评估。通过急诊医学研究,详细介绍了急性心肌缺血风险评估的演变,包括(a)认识到患者不适主观语言描述的局限性,(b)纳入高度特异性和敏感性的MI实验室生物标志物,以及(c)使用机械驱动的系列临床和实验室评估。今天的客观急诊方法对急性心肌缺血风险评估是相关的跨文化应用,因为需要在太平洋盆地的医疗保健。
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引用次数: 0
Socioeconomic Risk Factors for Extreme Preterm Birth in Hawai'i. 夏威夷极端早产的社会经济风险因素。
Q4 Medicine Pub Date : 2025-12-01 DOI: 10.62547/VTQZ2327
Joanna P Reinhardt, Maile M Taualii

Socioeconomic status and race/ethnicity are widely understood to be determinants of adverse birth outcomes, but studies have been limited by lack of income data in health records and aggregation of racial groups in reporting. This study aims to evaluate the relationship of socioeconomic status to extreme preterm birth outcomes in the diverse ethnic population of Hawai'i. Statistical analyses were conducted on Hawai'i birth records 2004-2013 linked to American Community Survey data by maternal residence. Community-level income demographics were stratified into wealth quintiles and stratum specific odds ratios were calculated for extreme preterm birth with analysis focused on the highest and lowest income-quintiles. The overall rates of extreme preterm birth were similar in high vs low-income communities, yet the individual risk factors were significantly different. In low-income communities, increased risk of extreme preterm birth was identified for women less than 20 years old and Black women, while in high-income communities, Native Hawaiian and Black women were at increased risk. Previous preterm birth, birth of a first child and cumulative maternal medical conditions were significant risk factors at all income levels. For Native Hawaiian women, the significant overall increased risk of extreme preterm birth persists in high-income communities but not in low-income communities, suggesting that increased risks previously attributed to Native Hawaiian race/ethnicity may be partially explained by low socioeconomic status.

人们普遍认为社会经济地位和种族/民族是不良出生结果的决定因素,但由于健康记录中缺乏收入数据和报告中汇总了种族群体,研究受到限制。本研究旨在评估社会经济地位与夏威夷多种族人群极端早产结局的关系。对2004-2013年夏威夷出生记录与美国社区调查数据进行统计分析。社区收入人口统计数据被划分为财富五分位数,并计算了极端早产的阶层特定优势比,分析重点是收入最高和最低的五分位数。在高收入和低收入社区中,极端早产的总体发生率相似,但个体风险因素有显著差异。在低收入社区,20岁以下的女性和黑人女性患极端早产的风险增加,而在高收入社区,夏威夷原住民和黑人女性患极端早产的风险增加。在所有收入水平中,以前的早产、第一个孩子的出生和累积的产妇医疗状况都是重要的风险因素。对于夏威夷土著妇女来说,高收入社区的极端早产风险总体显著增加,而低收入社区则没有,这表明先前归因于夏威夷土著种族/民族的风险增加可能部分归因于低社会经济地位。
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引用次数: 0
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