Introduction and objectives
Computed tomography of coronary arteries (CTCA) is emerging as the gold standard in the initial evaluation of chest pain. The aim of this study is to calculate the diagnostic performance and clinical usefulness of numerical models of arterial channels flow to assess non-invasive coronary fractional flow reserve by computed tomography (FFRct) compared to assessment by invasive angiography (FFR).
Methods
Computation of FFR from CTCA images was performed on 39 vessels in 32 patients who followed the usual clinical protocol including invasive coronary angiography and FFR following the usual clinical protocol. From the segmentation of the CTCA images, 3D geometry is obtained, and computational fluid dynamics techniques are applied to accurately reproduce the circulation of blood considering steady and unsteady circulatory conditions. Additional parameters as wall shear stress, stenosis resistance index and ΔFFRct were also calculated.
Results
The results obtained show a good correlation between FFRct and invasive FFR, without obtaining false positives values. In addition, no differences were observed between the simulations considering steady conditions or those considering the transient. Additional parameters as wall shear stress, stenosis resistance, and ΔFFRct also showed a good correlation with the invasive values.
Conclusions
This new model for calculating the FFRct from non-invasive 3D medical images of coronary tree has shown good agreement with those obtained using invasive techniques. Parameters as wall shear stress, stenosis resistance and ΔFFRct provide useful information that could be helpful in medical decision-making in those situations with FFR values close to the cut-off zone.