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Validation of a new model of non-invasive functional assessment of coronary lesions by computer tomography fractional flow reserve 计算机断层分数血流储备对冠状动脉病变无创功能评估新模型的验证
Q4 Medicine Pub Date : 2024-01-01 DOI: 10.1016/j.rccl.2023.07.004
Alberto Otero-Cacho , Diego López-Otero , Manuel Insúa Villa , Brais Díaz-Fernández , María Bastos-Fernández , Vicente Pérez-Muñuzuri , Alberto P. Muñuzuri , José Ramón González-Juanatey

Introduction and objectives

Computed tomography of coronary arteries (CTCA) is emerging as the gold standard in the initial evaluation of chest pain. The aim of this study is to calculate the diagnostic performance and clinical usefulness of numerical models of arterial channels flow to assess non-invasive coronary fractional flow reserve by computed tomography (FFRct) compared to assessment by invasive angiography (FFR).

Methods

Computation of FFR from CTCA images was performed on 39 vessels in 32 patients who followed the usual clinical protocol including invasive coronary angiography and FFR following the usual clinical protocol. From the segmentation of the CTCA images, 3D geometry is obtained, and computational fluid dynamics techniques are applied to accurately reproduce the circulation of blood considering steady and unsteady circulatory conditions. Additional parameters as wall shear stress, stenosis resistance index and ΔFFRct were also calculated.

Results

The results obtained show a good correlation between FFRct and invasive FFR, without obtaining false positives values. In addition, no differences were observed between the simulations considering steady conditions or those considering the transient. Additional parameters as wall shear stress, stenosis resistance, and ΔFFRct also showed a good correlation with the invasive values.

Conclusions

This new model for calculating the FFRct from non-invasive 3D medical images of coronary tree has shown good agreement with those obtained using invasive techniques. Parameters as wall shear stress, stenosis resistance and ΔFFRct provide useful information that could be helpful in medical decision-making in those situations with FFR values close to the cut-off zone.

导言和目的冠状动脉计算机断层扫描(CTCA)正在成为胸痛初步评估的金标准。本研究的目的是计算动脉通道流动数值模型的诊断性能和临床实用性,以评估计算机断层扫描(FFRct)与有创血管造影(FFR)评估相比的非侵入性冠状动脉分数血流储备。通过对 CTCA 图像进行分割,可获得三维几何图形,并应用计算流体动力学技术精确再现稳定和不稳定循环条件下的血液循环。结果显示,FFRct 与有创 FFR 之间具有良好的相关性,不会出现假阳性值。此外,在考虑稳定条件的模拟和考虑瞬态条件的模拟之间没有发现差异。其他参数如壁剪切应力、狭窄阻力和 ΔFFRct 也与有创值有很好的相关性。壁剪应力、狭窄阻力和 ΔFFRct 等参数提供了有用的信息,有助于在 FFR 值接近临界区域的情况下做出医疗决策。
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引用次数: 0
Sífilis cardiovascular 心血管梅毒
Q4 Medicine Pub Date : 2024-01-01 DOI: 10.1016/j.rccl.2023.05.001
Diana Isabel Katekaru-Tokeshi , Moisés Jiménez-Santos , Eric Kimura-Hayama
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引用次数: 0
Remote monitoring in remote places: an archipelago experience in heart failure patients with cardiac electronic devices 偏远地区的远程监控:群岛心衰患者使用心脏电子设备的经验
Q4 Medicine Pub Date : 2024-01-01 DOI: 10.1016/j.rccl.2023.09.002
Maria Inês Barradas, Fabiana Duarte, Inês Coutinho dos Santos, André Viveiros Monteiro, Anabela Tavares, Dinis Martins

Introduction and objectives

Remote monitoring (RM) is a new tool in heart failure (HF) patients with cardiac implantable electronic devices but its effect in clinical outcomes is still uncertain. In remote regions as islands HF management is even more challenging and RM may have a different impact. We aimed to assess its impact in clinical outcomes in an insular reality.

Methods

This was a retrospective, non-randomized study conducted in our hospital, that is the reference center of a nine-island archipelago. Patients in the HF remote monitoring program were matched 1:1 with usual standard of care patients.

Results

From 307 patients, 96 with RM (group 1 – G1) were matched 1:1 according to age ±2 years and gender with 96 usual standard of care (group 2 – G2) (mean age 69 years, 76% males, mean follow-up period 55 months). Primary endpoint was cardiovascular (CV) mortality and secondary endpoints all-cause mortality, HF hospitalizations at 12 months and at FUP. CV mortality was lower in G1 (hazard ratio [HR] 6.7; 95% confidence interval [95% CI] 1.46–30.87; P = .004), as well as all-cause mortality (HR, 5.7; 95% CI, 1.85–17.39; P < .001) and HF hospitalizations at 12 months (P = .02) with a tendency toward less hospitalizations during follow-up.

Conclusions

RM in the management of HF patients with cardiac implantable electronic devices in a remote geographic location, as a nine-island archipelago, was effective in reducing CV mortality, all-cause mortality and HF hospitalizations.

导言和目的远程监护(RM)是对植入心脏电子设备的心力衰竭(HF)患者进行治疗的一种新工具,但其对临床效果的影响仍不确定。在岛屿等偏远地区,心力衰竭的管理更具挑战性,RM 可能会产生不同的影响。方法这是一项回顾性、非随机研究,在我院进行,我院是九岛群岛的参考中心。结果307名患者中,96名接受RM治疗的患者(第1组--G1组)与96名接受常规标准治疗的患者(第2组--G2组)(平均年龄69岁,76%为男性,平均随访时间55个月)根据年龄(±2岁)和性别进行了1:1配对。主要终点是心血管(CV)死亡率,次要终点是全因死亡率、12 个月时的高血压住院率和家庭综合评估。G1 的心血管死亡率较低(危险比 [HR] 6.7;95% 置信区间 [95% CI] 1.46-30.87;P = .004),全因死亡率(HR,5.7;95% CI,1.85-17.39;P <.001)和 12 个月时的高血压住院率(P = .02)也较低,随访期间的住院率呈下降趋势。在九岛群岛这样一个偏远的地理位置管理安装了心脏植入式电子设备的高血压患者的结论能有效降低心血管疾病死亡率、全因死亡率和高血压住院率。
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引用次数: 0
Cambios en el diagnóstico de la amiloidosis en las últimas dos décadas. ¿Que 20 años no es nada? 过去二十年淀粉样变性病诊断的变化--20 年算得了什么?
Q4 Medicine Pub Date : 2024-01-01 DOI: 10.1016/j.rccl.2023.10.005
Fernando Domínguez
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引用次数: 0
Estimulación fisiológica: estado actual y perspectivas futuras 生理刺激:现状与未来展望
Q4 Medicine Pub Date : 2023-11-01 DOI: 10.1016/j.rccl.2023.06.003
Cristina Lozano Granero , Álvaro Marco del Castillo , Sem Briongos Figuero , Miguel Amores Luque

Conduction system pacing is a cardiac pacing modality that seeks to maintain ventricular electromechanical activation synchrony through direct stimulation of the specific conduction system, generally the bundle of His or the left bundle branch. Although technically more complex than conventional right ventricular pacing, the advent of dedicated tools has favored its implementation in clinical practice as a more physiologic alternative to conventional right ventricular pacing and as a rescue strategy when conventional resynchronization therapy through biventricular pacing is not feasible. More recently, the growing scientific evidence that compares it to the latter would place it as a real alternative strategy in patients with heart failure and an indication for resynchronization. This text reviews the fundamentals of the main implant modalities and technique, the available scientific evidence, and future prospects.

传导系统起搏是一种心脏起搏方式,旨在通过直接刺激特定的传导系统(通常是肱动脉束或左束支)来维持心室机电激活的同步性。虽然在技术上比传统的右心室起搏更为复杂,但专用工具的出现促进了其在临床实践中的应用,使其成为传统右心室起搏的一种更具生理学意义的替代方法,也是在无法通过双心室起搏进行传统再同步化治疗时的一种挽救策略。最近,越来越多的科学证据将其与后者进行比较,从而将其作为心衰患者的真正替代策略和再同步化的适应症。本文回顾了主要植入方式和技术的基本原理、现有科学证据以及未来前景。
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引用次数: 0
IV CardioMIR: el Congreso de los Jóvenes Cardiólogos IV CardioMIR:青年心脏病学家大会
Q4 Medicine Pub Date : 2023-11-01 DOI: 10.1016/j.rccl.2023.11.001
Ana Laffond , Javier Borrego , David González-Calle , Pedro Cepas-Guillén

The IV edition of the Congress of Young Cardiologists, CardioMIR, was held in the city of Madrid on September 22 and 23, 2023, bringing together around 550 young cardiologists to learn about the latest developments in the diagnostic approach and therapeutics of cardiovascular disease. The congress also aims to be a meeting point for young cardiologists from the Spanish Society of Cardiology, especially residents, where they can share experiences and concerns. The aim of this article is to summarize of the main topics addressed in the IV edition of CardioMIR.

第四届青年心脏病学家大会(CardioMIR)于 2023 年 9 月 22 日和 23 日在马德里举行,约 550 名青年心脏病学家汇聚一堂,了解心血管疾病诊断方法和疗法的最新进展。大会还旨在成为西班牙心脏病学会年轻心脏病专家(尤其是住院医师)的汇聚点,让他们可以分享经验和关切。本文旨在总结第四届 CardioMIR 大会的主要议题。
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引用次数: 0
«Mind the gap». Fundamentos de economía de la salud para una comunicación efectiva entre clínicos y gestores sanitarios "注意差距。临床医生与健康管理者之间有效沟通的健康经济学基础。
Q4 Medicine Pub Date : 2023-11-01 DOI: 10.1016/j.rccl.2023.06.004
Ana Barradas-Pires , Lucía Matute-Blanco , Mario Diaznuila-Alcazar

Health Economics is an unfriendly topic for most clinical cardiologists. However, if we want to bridge the gap between patients and healthcare management, it is essential that decisions regarding new drugs, procedures, and technologies involve clinical professionals. Our unique position allows us to provide valuable insights and expertise in our fields and bring added value for decision making in the health system as a whole. Equipping clinical cardiologists with basic knowledge and tools in Health Economics and Economic Evaluation (such as cost-effectiveness or cost-utility studies) is crucial to develop studies that accurately reflect the clinical impact of diseases, both for patients and the healthcare system. By getting involved, clinicians can play a vital role in shaping the future of healthcare systems and influencing the allocation of (usually scarce) resources to ensure optimal care for our patients.

对于大多数临床心脏病专家来说,卫生经济学是一个不友好的话题。但是,如果我们想在患者和医疗管理之间架起一座桥梁,那么有关新药、新程序和新技术的决策就必须有临床专业人员的参与。我们的独特地位使我们能够在各自领域提供有价值的见解和专业知识,并为整个医疗系统的决策带来附加值。让临床心脏病专家掌握卫生经济学和经济评估(如成本效益或成本效用研究)方面的基础知识和工具,对于开展能准确反映疾病对患者和医疗系统的临床影响的研究至关重要。通过参与其中,临床医生可以在塑造医疗保健系统的未来和影响(通常是稀缺的)资源分配方面发挥重要作用,从而确保为患者提供最佳治疗。
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引用次数: 0
Introducción 导言
Q4 Medicine Pub Date : 2023-11-01 DOI: 10.1016/j.rccl.2023.07.005
Pablo Díez-Villanueva , María Thiscal López Lluva
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引用次数: 0
Insuficiencia tricuspídea. Definición y actualización sobre su historia natural, diagnóstico y tratamiento 三尖瓣反流。三尖瓣反流的定义及其自然史、诊断和治疗的最新进展。
Q4 Medicine Pub Date : 2023-11-01 DOI: 10.1016/j.rccl.2023.08.001
Juan Carlos Gómez Polo , Noemí Ramos López , Irene Carrión Sánchez , María Thiscal López-Lluva

Tricuspid regurgitation is the most prevalent valvular disease in the general population. However, it has traditionally been largely forgotten. This article reviews anatomy, etiology (with special attention to atriogenic tricuspid regurgitation), prognostic involvement, diagnostic methods, and therapeutic indication of this valve disease. In addition, the literature is reviewed regarding the selection of candidates, the importance of early management, surgery, and recent percutaneous treatment options, which are undoubtedly revolutionizing the management of this entity.

三尖瓣反流是普通人群中最常见的瓣膜疾病。然而,它历来被人们所遗忘。本文回顾了这种瓣膜疾病的解剖、病因(特别关注寰枢膜三尖瓣反流)、预后参与、诊断方法和治疗指征。此外,文章还回顾了有关候选者的选择、早期管理的重要性、手术以及最近的经皮治疗方案等方面的文献,这些方案无疑正在彻底改变这一疾病的治疗方法。
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引用次数: 0
Situación actual del abordaje integral de la insuficiencia cardiaca en España. Proyecto OPTIMISE-IC 西班牙心力衰竭综合治疗的现状。项目优化-IC
Q4 Medicine Pub Date : 2023-10-01 DOI: 10.1016/j.rccl.2023.07.003
Vivencio Barrios , Eduardo Barge-Caballero , M. José Castillo Moraga , M. Isabel Egocheaga Cabello , Carlos Escobar Cervantes , Román Freixa-Pamias , Juan Carlos Obaya Rebollar , Carolina Ortiz Cortés , María Cruz Seoane Vicente

Introduction and objectives

To determine the current situation about the clinical management of heart failure (HF) in primary care (PC) and cardiology, in order to identify potential areas for improvement in the healthcare continuity.

Methods

The program was implemented through joint work sessions between PC and cardiology in our country, in which possible deficiencies, difficulties, and areas for improvement were identified in the integrative management of patients with HF.

Results

66 sessions were performed throughout Spain, with a total of 1187 attendees. 61.8% of the participants indicated that the healthcare centers did not have a HF cardiology referrer, in 64.7% the relationship between both healthcare levels was isolated and communication was carried out predominantly through telematic tools. 88.2% of PC physicians could request natriuretic peptides directly, but in 75.8% the echocardiogram had to be requested through cardiology. In 61.8% of the cases there was a therapeutic plan to optimize the treatment with quadruple therapy, although in 82.4% the full doses were not attained. In most centers (60.3%) there was no expert nurse in the management of HF.

Conclusions

In Spain there are significant deficiencies in the integrative management of patients with HF. A higher education of PC physicians and nurses, a better coordination between both healthcare levels, and the development of local protocols that facilitates treatment optimization, could be helpful to improve this situation.

引言和目的确定初级保健(PC)和心脏病学中心力衰竭(HF)临床管理的现状,以确定医疗连续性的潜在改进领域。方法该项目在我国通过PC和心脏病学的联合工作会议实施,其中确定了HFS患者综合管理中可能存在的不足、困难和改进领域。结果在西班牙各地进行了66次会议,共有1187人参加。61.8%的参与者表示,医疗保健中心没有HF心脏病学推荐人,64.7%的参与者表示两个医疗保健水平之间的关系是孤立的,沟通主要通过远程信息处理工具进行。88.2%的PC医生可以直接要求利钠肽,但75.8%的医生必须通过心脏病学要求进行超声心动图检查。61.8%的病例有一个优化四重疗法治疗的治疗计划,尽管82.4%的病例没有达到全剂量。在大多数中心(60.3%),没有专业护士参与HF的管理。结论在西班牙,HF患者的综合管理存在重大不足。PC医生和护士的高等教育,两个医疗保健级别之间的更好协调,以及制定有助于优化治疗的地方方案,可能有助于改善这种情况。
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引用次数: 0
期刊
REC: CardioClinics
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