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Amide proton transfer-weighted CEST MRI for radiotherapy target delineation of glioblastoma: a prospective pilot study. 用于胶质母细胞瘤放疗靶点划定的酰胺质子转移加权CEST磁共振成像:一项前瞻性试验研究。
IF 3.7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-30 DOI: 10.1186/s41747-024-00523-4
Patrick L Y Tang, Alejandra Méndez Romero, Remi A Nout, Caroline van Rij, Cleo Slagter, Annemarie T Swaak-Kragten, Marion Smits, Esther A H Warnert

Background: Extensive glioblastoma infiltration justifies a 15-mm margin around the gross tumor volume (GTV) to define the radiotherapy clinical target volume (CTV). Amide proton transfer (APT)-weighted imaging could enable visualization of tumor infiltration, allowing more accurate GTV delineation. We quantified the impact of integrating APT-weighted imaging into GTV delineation of glioblastoma and compared two APT-weighted quantification methods-magnetization transfer ratio asymmetry (MTRasym) and Lorentzian difference (LD) analysis-for target delineation.

Methods: Nine glioblastoma patients underwent an extended imaging protocol prior to radiotherapy, yielding APT-weighted MTRasym and LD maps. From both maps, biological tumor volumes were generated (BTVMTRasym and BTVLD) and added to the conventional GTV to generate biological GTVs (GTVbio,MTRasym and GTVbio,LD). Wilcoxon signed-rank tests were performed for comparisons.

Results: The GTVbio,MTRasym and GTVbio,LD were significantly larger than the conventional GTV (p ≤ 0.022), with a median volume increase of 9.3% and 2.1%, respectively. The GTVbio,MTRasym and GTVbio,LD were significantly smaller than the CTV (p = 0.004), with a median volume reduction of 72.1% and 70.9%, respectively. There was no significant volume difference between the BTVMTRasym and BTVLD (p = 0.074). In three patients, BTVMTRasym delineation was affected by elevated signals at the brain periphery due to residual motion artifacts; this elevation was absent on the APT-weighted LD maps.

Conclusion: Larger biological GTVs compared to the conventional GTV highlight the potential of APT-weighted imaging for radiotherapy target delineation of glioblastoma. APT-weighted LD mapping may be advantageous for target delineation as it may be more robust against motion artifacts.

Relevance statement: The introduction of APT-weighted imaging may, ultimately, enhance visualization of tumor infiltration and eliminate the need for the substantial 15-mm safety margin for target delineation of glioblastoma. This could reduce the risk of radiation toxicity while still effectively irradiating the tumor.

Trial registration: NCT05970757 (ClinicalTrials.gov).

Key points: Integration of APT-weighted imaging into target delineation for radiotherapy is feasible. The integration of APT-weighted imaging yields larger GTVs in glioblastoma. APT-weighted LD mapping may be more robust against motion artifacts than APT-weighted MTRasym.

背景:胶质母细胞瘤的广泛浸润要求在肿瘤总体积(GTV)周围留出15毫米的余量,以确定放疗的临床靶体积(CTV)。酰胺质子转移(APT)加权成像可实现肿瘤浸润的可视化,从而更准确地划分 GTV。我们量化了将 APT 加权成像整合到胶质母细胞瘤 GTV 划分中的影响,并比较了两种 APT 加权量化方法--磁化传递比不对称(MTRasym)和洛伦兹差分(LD)分析--对目标划定的影响:九名胶质母细胞瘤患者在放疗前接受了扩展成像方案,获得了APT加权MTRasym和LD图。根据这两张图生成生物肿瘤体积(BTVMTRasym 和 BTVLD),并与常规 GTV 相加生成生物 GTV(GTVbio,MTRasym 和 GTVbio,LD)。比较结果采用 Wilcoxon 符号秩检验:GTVbio,MTRasym和GTVbio,LD明显大于常规GTV(P≤0.022),体积增加的中位数分别为9.3%和2.1%。GTVbio,MTRasym和GTVbio,LD明显小于CTV(p = 0.004),体积减少的中位数分别为72.1%和70.9%。BTVMTRasym 和 BTVLD 的体积差异不大(p = 0.074)。在三名患者中,BTVMTRasym的划定受到了残留运动伪影导致的大脑外围信号升高的影响;而在APT加权LD图上则没有这种升高:结论:与传统 GTV 相比,更大的生物 GTV 凸显了 APT 加权成像在胶质母细胞瘤放疗靶区划分方面的潜力。APT加权低密度成像在靶点划分方面可能更具优势,因为它对运动伪影的抵抗力更强:APT 加权成像的引入最终可能会增强肿瘤浸润的可视化,并使胶质母细胞瘤的靶区划分不再需要 15 毫米的安全裕度。这可以在有效照射肿瘤的同时降低辐射毒性风险:试验注册:NCT05970757(ClinicalTrials.gov):要点:将APT加权成像整合到放射治疗的靶区划分中是可行的。在胶质母细胞瘤中整合 APT 加权成像可获得更大的 GTV。与 APT 加权 MTRasym 相比,APT 加权 LD 映射对运动伪影的抗干扰能力更强。
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引用次数: 0
Transfer learning classification of suspicious lesions on breast ultrasound: is there room to avoid biopsies of benign lesions? 乳腺超声可疑病变的迁移学习分类:是否有避免良性病变活检的余地?
IF 3.7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-28 DOI: 10.1186/s41747-024-00480-y
Paolo De Marco, Valerio Ricciardi, Marta Montesano, Enrico Cassano, Daniela Origgi

Background: Breast cancer (BC) is the most common malignancy in women and the second cause of cancer death. In recent years, there has been a strong development in artificial intelligence (AI) applications in medical imaging for several tasks. Our aim was to evaluate the potential of transfer learning with convolutional neural networks (CNNs) in discriminating suspicious breast lesions on ultrasound images.

Methods: Transfer learning performances of five different CNNs (Inception V3, Xception, Densenet121, VGG 16, and ResNet50) were evaluated on a public and on an institutional dataset (526 and 392 images, respectively), customizing the top layers for the specific task. Institutional images were contoured by an expert radiologist and processed to feed the CNNs for training and testing. Postimaging biopsies were used as a reference standard for classification. The area under the receiver operating curve (AUROC) was used to assess diagnostic performance.

Results: Networks performed very well on the public dataset (AUROC 0.938-0.996). The direct generalization to the institutional dataset resulted in lower performances (max AUROC 0.676); however, when tested on BI-RADS 3 and BI-RADS 5 only, results were improved (max AUROC 0.792). Good results were achieved on the institutional dataset (AUROC 0.759-0.818) and, when selecting a threshold of 2% for classification, a sensitivity of 0.983 was obtained for three of five CNNs, with the potential to spare biopsy in 15.3%-18.6% of patients.

Conclusion: In conclusion, transfer learning with CNNs may achieve high sensitivity and might be used as a support tool in managing suspicious breast lesions on ultrasound images.

Relevance statement: Transfer learning is a powerful technique to exploit the performances of well-trained CNNs for image classification. In a clinical scenario, it might be useful for the management of suspicious breast lesions on breast ultrasound, potentially sparing biopsy in a non-negligible number of patients.

Key points: Properly trained CNNs with transfer learning are highly effective in differentiating benign and malignant lesions on breast ultrasound. Setting clinical thresholds increased sensitivity. CNNs might be useful as support tools in managing suspicious lesions on breast ultrasound.

背景:乳腺癌(BC)是女性最常见的恶性肿瘤,也是第二大癌症死因。近年来,人工智能(AI)在医学影像领域的应用得到了蓬勃发展。我们的目的是评估卷积神经网络(CNN)的迁移学习在辨别超声图像上可疑乳腺病变方面的潜力:我们在公共数据集和机构数据集(分别为 526 张和 392 张图像)上评估了五种不同 CNN(Inception V3、Xception、Densenet 121、VGG 16 和 ResNet50)的迁移学习性能,并针对特定任务定制了顶层。机构图像由放射科专家绘制轮廓,并经过处理,为 CNN 的训练和测试提供素材。成像后的活组织切片被用作分类的参考标准。接受者操作曲线下面积(AUROC)用于评估诊断性能:网络在公共数据集上的表现非常好(AUROC 0.938-0.996)。直接推广到机构数据集的结果是性能较低(最大 AUROC 0.676);然而,仅在 BI-RADS 3 和 BI-RADS 5 上测试时,结果有所改善(最大 AUROC 0.792)。在机构数据集上取得了良好的结果(AUROC 0.759-0.818),当选择 2% 的分类阈值时,五个 CNN 中的三个灵敏度达到了 0.983,有可能使 15.3%-18.6% 的患者免于活检:总之,利用 CNN 进行迁移学习可获得较高的灵敏度,可作为一种辅助工具用于管理超声图像上的可疑乳腺病变:迁移学习是一种强大的技术,可利用训练有素的 CNN 的性能进行图像分类。在临床应用中,它可能有助于处理乳腺超声图像上的可疑乳腺病变,从而使相当数量的患者免于活检:要点:经过适当训练的具有迁移学习能力的 CNN 在区分乳腺超声良性和恶性病变方面非常有效。设置临床阈值可提高灵敏度。在管理乳腺超声可疑病变时,CNN 可能是有用的辅助工具。
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引用次数: 0
Ultrasound-guided cryoablation of early breast cancer: safety, technical efficacy, patients' satisfaction, and outcome prediction with MRI/CEM: a pilot case-control study. 超声引导下的早期乳腺癌冷冻消融:安全性、技术疗效、患者满意度以及磁共振成像/CEM的结果预测:一项试点病例对照研究。
IF 3.7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-22 DOI: 10.1186/s41747-024-00515-4
Francesca Galati, Marcella Pasculli, Roberto Maroncelli, Veronica Rizzo, Giuliana Moffa, Bruna Cerbelli, Giulia d'Amati, Carlo Catalano, Federica Pediconi

Background: This pilot prospective study aimed to evaluate ultrasound-guided cryoablation of breast cancer (BC) by assessing: (i) technical efficacy as the presence of necrosis in surgical specimens and rate of complete tumor ablation; (ii) safety as incidence and severity of complications; and (iii) patients' satisfaction using a dedicated questionnaire. In addition, (iv) we tested the capability of magnetic resonance imaging (MRI) or contrast-enhanced mammography (CEM) to predict cryoablation efficacy.

Methods: From 07/2022 to 01/2023, we enrolled 20 patients with early-stage BC scheduled for breast surgery. Ten of them, with a cryo-feasible cancer location, were sent to cryoablation (cryo-group) and ten to routine surgical practice (control group). Both groups underwent surgery and were asked to answer a satisfaction questionnaire.

Results: Of eleven patients screened for cryoablation, only one refused to be treated at another hospital (acceptance rate 10/11, 91%). Surgery was quadrantectomy in 19 cases and mastectomy in 1. In the cryo-group, the procedure was completed and steatonecrosis was observed in 10/10 cases, with complete tumor ablation in nine of them. The post-procedural status was evaluated with MRI in five patients, with CEM in four patients, and with ultrasound in one patient who refused MRI and CEM. MRI or CEM correctly predicted complete cryoablation in eight patients and incomplete cryoablation in one patient. Patients in both groups did not have serious complications and responded positively to satisfaction questionnaires.

Conclusion: Ultrasound-guided cryoablation of early-stage BC is well accepted by patients, effective, and safe. MRI and CEM were able to predict the procedure's technical efficacy.

Trial registration: https://clinicaltrials.gov/study/NCT05727813 updated February 14, 2023.

Relevance statement: Our pilot study showed that ultrasound-guided cryoablation is a promising nonsurgical alternative for treating early-stage BC.

Key points: Ultrasound-guided cryoablation was effective and safe in early BC patients. The procedure was well-tolerated, with low morbidity and high patient satisfaction. MRI and CEM predicted cryoablation efficacy, in accordance with histopathologic findings. Cryoablation can be considered a potential alternative to surgery in selected patients.

研究背景这项试验性前瞻性研究旨在通过评估:(i) 技术疗效,即手术标本是否出现坏死和肿瘤完全消融率;(ii) 安全性,即并发症的发生率和严重程度;(iii) 使用专用问卷调查患者的满意度,对乳腺癌(BC)的超声引导下冷冻消融术进行评估。此外,(iv) 我们还测试了磁共振成像(MRI)或对比增强乳腺造影术(CEM)预测冷冻消融疗效的能力:方法:2022 年 7 月至 2023 年 1 月,我们招募了 20 名计划进行乳腺手术的早期 BC 患者。其中10名患者的癌变部位可进行冷冻消融(冷冻组),10名患者进行常规手术(对照组)。两组患者均接受了手术,并被要求回答满意度问卷:在接受冷冻消融术的 11 名患者中,只有一人拒绝在其他医院接受治疗(接受率为 10/11,91%)。在冷冻组中,10/10 的患者完成了手术并观察到了脂肪坏死,其中 9 例完全消融了肿瘤。对 5 例患者进行了核磁共振成像评估,对 4 例患者进行了 CEM 评估,对 1 例拒绝接受核磁共振成像和 CEM 的患者进行了超声波评估。核磁共振成像或 CEM 正确预测了 8 名患者的完全冷冻消融和 1 名患者的不完全冷冻消融。两组患者均未出现严重并发症,并对满意度调查问卷做出了积极回应:结论:超声引导下的早期 BC 冷冻消融术被患者广泛接受,有效且安全。核磁共振成像和CEM能够预测手术的技术疗效。试验注册:https://clinicaltrials.gov/study/NCT05727813,更新日期:2023年2月14日。相关声明:我们的试验研究表明,超声引导下冷冻消融术是治疗早期BC的一种很有前景的非手术疗法:要点:超声引导下冷冻消融术对早期BC患者有效且安全。手术耐受性良好,发病率低,患者满意度高。磁共振成像和CEM与组织病理学结果一致,可预测冷冻消融的疗效。冷冻消融术可被视为选定患者手术的潜在替代方案。
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引用次数: 0
Quantitative ultrasound assessment of fatty infiltration of the rotator cuff muscles using backscatter coefficient. 利用反向散射系数对肩袖肌肉的脂肪浸润进行定量超声评估。
IF 3.7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-22 DOI: 10.1186/s41747-024-00522-5
Marco Toto-Brocchi, Yuanshan Wu, Saeed Jerban, Aiguo Han, Michael Andre, Sameer B Shah, Eric Y Chang

Background: To prospectively evaluate ultrasound backscatter coefficients (BSCs) of the supraspinatus and infraspinatus muscles and compare with Goutallier classification on magnetic resonance imaging (MRI).

Methods: Fifty-six participants had shoulder MRI exams and ultrasound exams of the supraspinatus and infraspinatus muscles. Goutallier MRI grades were determined and BSCs were measured. Group means were compared and the strength of relationships between the measures were determined. Using binarized Goutallier groups (0-2 versus 3-4), areas under the receiver operating characteristic curves (AUROCs) were calculated. The nearest integer cutoff value was determined using Youden's index.

Results: BSC values were significantly different among most Goutallier grades for the supraspinatus and infraspinatus muscles (both p < 0.001). Strong correlations were found between the BSC values and Goutallier grades for the supraspinatus (τb = 0.72, p < 0.001) and infraspinatus (τb = 0.79, p < 0.001) muscles. BSC showed excellent performance for classification of the binarized groups (0-2 versus 3-4) for both supraspinatus (AUROC = 0.98, p < 0.0001) and infraspinatus (AUROC = 0.98, p < 0.0001) muscles. Using a cutoff BSC value of -17 dB, sensitivity, specificity, and accuracy for severe fatty infiltration were 87.0%, 90.0%, and 87.5% for the supraspinatus muscle, and 93.6%, 87.5%, and 92.7% for the infraspinatus muscle.

Conclusion: BSC can be applied to the rotator cuff muscles for assessment of fatty infiltration. For both the supraspinatus and infraspinatus muscles, BSC values significantly increased with higher Goutallier grades and showed strong performance in distinguishing low versus high Goutallier grades.

Relevance statement: Fatty infiltration of the rotator cuff muscles can be quantified using BSC values, which are higher with increasing Goutallier grades.

Key points: Ultrasound BSC measurements are reliable for the quantification of muscle fatty infiltration. BCS values increased with higher Goutallier MRI grades. BCS values demonstrated high performance for distinguishing muscle fatty infiltration groups.

背景:前瞻性评估冈上肌和冈下肌的超声波反向散射系数(BSC),并与磁共振成像(MRI)上的Goutallier分类进行比较:方法:56 名参与者接受了肩部核磁共振成像检查和冈上肌与冈下肌超声波检查。确定 Goutallier MRI 分级并测量 BSC。对各组平均值进行比较,并确定测量值之间的关系强度。使用二值化的 Goutallier 组(0-2 与 3-4),计算接收者操作特征曲线下的面积 (AUROC)。使用尤登指数(Youden's index)确定最接近的整数截断值:结果:冈上肌和冈下肌的 BSC 值在大多数 Goutallier 等级之间存在明显差异(均为 p b = 0.72,p b = 0.79,p 结论:冈上肌和冈下肌的 BSC 值在大多数 Goutallier 等级之间存在明显差异(均为 p b = 0.72,p b = 0.79,p 结论):BSC 可用于肩袖肌肉脂肪浸润的评估。对于冈上肌和冈下肌,BSC 值随着 Goutallier 等级的升高而显著增加,并在区分低 Goutallier 等级和高 Goutallier 等级方面表现出色:肩袖肌肉的脂肪浸润可通过 BSC 值进行量化,随着 Goutallier 等级的增加,BSC 值也会增加:要点:超声 BSC 测量是量化肌肉脂肪浸润的可靠方法。BCS值随着Goutallier MRI分级的增加而增加。BCS值在区分肌肉脂肪浸润组别方面表现出很高的性能。
{"title":"Quantitative ultrasound assessment of fatty infiltration of the rotator cuff muscles using backscatter coefficient.","authors":"Marco Toto-Brocchi, Yuanshan Wu, Saeed Jerban, Aiguo Han, Michael Andre, Sameer B Shah, Eric Y Chang","doi":"10.1186/s41747-024-00522-5","DOIUrl":"10.1186/s41747-024-00522-5","url":null,"abstract":"<p><strong>Background: </strong>To prospectively evaluate ultrasound backscatter coefficients (BSCs) of the supraspinatus and infraspinatus muscles and compare with Goutallier classification on magnetic resonance imaging (MRI).</p><p><strong>Methods: </strong>Fifty-six participants had shoulder MRI exams and ultrasound exams of the supraspinatus and infraspinatus muscles. Goutallier MRI grades were determined and BSCs were measured. Group means were compared and the strength of relationships between the measures were determined. Using binarized Goutallier groups (0-2 versus 3-4), areas under the receiver operating characteristic curves (AUROCs) were calculated. The nearest integer cutoff value was determined using Youden's index.</p><p><strong>Results: </strong>BSC values were significantly different among most Goutallier grades for the supraspinatus and infraspinatus muscles (both p < 0.001). Strong correlations were found between the BSC values and Goutallier grades for the supraspinatus (τ<sub>b</sub> = 0.72, p < 0.001) and infraspinatus (τ<sub>b</sub> = 0.79, p < 0.001) muscles. BSC showed excellent performance for classification of the binarized groups (0-2 versus 3-4) for both supraspinatus (AUROC = 0.98, p < 0.0001) and infraspinatus (AUROC = 0.98, p < 0.0001) muscles. Using a cutoff BSC value of -17 dB, sensitivity, specificity, and accuracy for severe fatty infiltration were 87.0%, 90.0%, and 87.5% for the supraspinatus muscle, and 93.6%, 87.5%, and 92.7% for the infraspinatus muscle.</p><p><strong>Conclusion: </strong>BSC can be applied to the rotator cuff muscles for assessment of fatty infiltration. For both the supraspinatus and infraspinatus muscles, BSC values significantly increased with higher Goutallier grades and showed strong performance in distinguishing low versus high Goutallier grades.</p><p><strong>Relevance statement: </strong>Fatty infiltration of the rotator cuff muscles can be quantified using BSC values, which are higher with increasing Goutallier grades.</p><p><strong>Key points: </strong>Ultrasound BSC measurements are reliable for the quantification of muscle fatty infiltration. BCS values increased with higher Goutallier MRI grades. BCS values demonstrated high performance for distinguishing muscle fatty infiltration groups.</p>","PeriodicalId":36926,"journal":{"name":"European Radiology Experimental","volume":"8 1","pages":"119"},"PeriodicalIF":3.7,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11496476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gadolinium-based coronary CT angiography on a clinical photon-counting-detector system: a dynamic circulating phantom study. 临床光子计数探测器系统上的钆基冠状动脉 CT 血管造影:动态循环模型研究。
IF 3.7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-18 DOI: 10.1186/s41747-024-00501-w
Dmitrij Kravchenko, Chiara Gnasso, U Joseph Schoepf, Milan Vecsey-Nagy, Giuseppe Tremamunno, Jim O'Doherty, Andrew Zhang, Julian A Luetkens, Daniel Kuetting, Ulrike Attenberger, Bernhard Schmidt, Akos Varga-Szemes, Tilman Emrich

Background: Coronary computed tomography angiography (CCTA) offers non-invasive diagnostics of the coronary arteries. Vessel evaluation requires the administration of intravenous contrast. The purpose of this study was to evaluate the utility of gadolinium-based contrast agent (GBCA) as an alternative to iodinated contrast for CCTA on a first-generation clinical dual-source photon-counting-detector (PCD)-CT system.

Methods: A dynamic circulating phantom containing a three-dimensional-printed model of the thoracic aorta and the coronary arteries were used to evaluate injection protocols using gadopentetate dimeglumine at 50%, 100%, 150%, and 200% of the maximum approved clinical dose (0.3 mmol/kg). Virtual monoenergetic image (VMI) reconstructions ranging from 40 keV to 100 keV with 5 keV increments were generated on a PCD-CT. Contrast-to-noise ratio (CNR) was calculated from attenuations measured in the aorta and coronary arteries and noise measured in the background tissue. Attenuation of at least 350 HU was deemed as diagnostic.

Results: The highest coronary attenuation (441 ± 23 HU, mean ± standard deviation) and CNR (29.5 ± 1.5) was achieved at 40 keV and at the highest GBCA dose (200%). There was a systematic decline of attenuation and CNR with higher keV reconstructions and lower GBCA doses. Only reconstructions at 40 and 45 keV at 200% and 40 keV at 150% GBCA dose demonstrated sufficient attenuation above 350 HU.

Conclusion: Current PCD-CT protocols and settings are unsuitable for the use of GBCA for CCTA at clinically approved doses. Future advances to the PCD-CT system including a 4-threshold mode, as well as multi-material decomposition may add new opportunities for k-edge imaging of GBCA.

Relevance statement: Patients allergic to iodine-based contrast media and the future of multicontrast CT examinations would benefit greatly from alternative contrast media, but the utility of GBCA for coronary photon-counting-dector-CT angiography remains limited without further optimization of protocols and scanner settings.

Key points: GBCA-enhanced coronary PCD-CT angiography is not feasible at clinically approved doses. GBCAs have potential applications for the visualization of larger vessels, such as the aorta, on PCD-CT angiography. Higher GBCA doses and lower keV reconstructions achieved higher attenuation values and CNR.

背景:冠状动脉计算机断层扫描血管造影术(CCTA)可对冠状动脉进行无创诊断。血管评估需要静脉注射造影剂。本研究的目的是评估在第一代临床双源光子计数探测器(PCD)-CT 系统上使用钆基造影剂(GBCA)替代碘化造影剂进行 CCTA 的实用性:方法:使用一个包含胸主动脉和冠状动脉三维打印模型的动态循环模型来评估使用钆喷酸二葡胺的注射方案,注射剂量为批准的最大临床剂量(0.3 毫摩尔/千克)的 50%、100%、150% 和 200%。在 PCD-CT 上生成的虚拟单能量图像 (VMI) 重建范围从 40 keV 到 100 keV,增量为 5 keV。根据主动脉和冠状动脉测得的衰减和背景组织测得的噪声计算出对比-噪声比(CNR)。至少 350 HU 的衰减被视为具有诊断意义:结果:在 40 keV 和最高 GBCA 剂量(200%)下,冠状动脉衰减(441 ± 23 HU,平均值 ± 标准偏差)和 CNR(29.5 ± 1.5)最高。衰减和 CNR 随较高的 KeV 重建和较低的 GBCA 剂量而系统性下降。只有 GBCA 剂量为 200% 的 40 和 45 keV 重建以及 GBCA 剂量为 150% 的 40 keV 重建显示出 350 HU 以上的足够衰减:结论:目前的 PCD-CT 方案和设置不适合将 GBCA 用于临床认可剂量的 CCTA。PCD-CT 系统未来的进步包括 4 阈值模式和多材料分解,这可能会为 GBCA 的 k 边成像增加新的机会:对碘基造影剂过敏的患者以及未来的多对比 CT 检查将从替代造影剂中获益匪浅,但如果不进一步优化方案和扫描仪设置,GBCA 在冠状动脉光子计数矢量 CT 血管造影中的应用仍然有限:要点:GBCA 增强冠状动脉 PCD-CT 血管造影在临床认可的剂量下是不可行的。GBCA 有可能应用于 PCD-CT 血管造影对主动脉等较大血管的成像。较高的 GBCA 剂量和较低的 keV 重建可获得较高的衰减值和 CNR。
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引用次数: 0
Correction: Efficacy of compressed sensing and deep learning reconstruction for adult female pelvic MRI at 1.5 T. 更正:压缩传感和深度学习重建技术在 1.5 T 下用于成年女性盆腔磁共振成像的效果。
IF 3.7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-16 DOI: 10.1186/s41747-024-00521-6
Takahiro Ueda, Kaori Yamamoto, Natsuka Yazawa, Ikki Tozawa, Masato Ikedo, Masao Yui, Hiroyuki Nagata, Masahiko Nomura, Yoshiyuki Ozawa, Yoshiharu Ohno
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引用次数: 0
Quantitative CT imaging and radiation-absorbed dose estimations of 166Ho microspheres: paving the way for clinical application. 166Ho 微球的定量 CT 成像和辐射吸收剂量估算:为临床应用铺平道路。
IF 3.7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-14 DOI: 10.1186/s41747-024-00511-8
Chiron Morsink, Nienke Klaassen, Gerrit van de Maat, Milou Boswinkel, Alexandra Arranja, Robin Bruggink, Ilva van Houwelingen, Irene Schaafsma, Jan Willem Hesselink, Frank Nijsen, Bas van Nimwegen
<p><strong>Background: </strong>Microbrachytherapy enables high local tumor doses sparing surrounding tissues by intratumoral injection of radioactive holmium-166 microspheres (<sup>166</sup>Ho-MS). Magnetic resonance imaging (MRI) cannot properly detect high local Ho-MS concentrations and single-photon emission computed tomography has insufficient resolution. Computed tomography (CT) is quicker and cheaper with high resolution and previously enabled Ho quantification. We aimed to optimize Ho quantification on CT and to implement corresponding dosimetry.</p><p><strong>Methods: </strong>Two scanners were calibrated for Ho detection using phantoms and multiple settings. Quantification was evaluated in five phantoms and seven canine patients using subtraction and thresholding including influences of the target tissue, injected amounts, acquisition parameters, and quantification volumes. Radiation-absorbed dose estimation was implemented using a three-dimensional <sup>166</sup>Ho specific dose point kernel generated with Monte Carlo simulations.</p><p><strong>Results: </strong>CT calibration showed a near-perfect linear relation between radiodensity (HU) and Ho concentrations for all conditions, with differences between scanners. Ho detection during calibration was higher using lower tube voltages, soft-tissue kernels, and without a scanner detection limit. The most accurate Ho recovery in phantoms was 102 ± 11% using a threshold of mean tissue HU + (2 × standard deviation) and in patients 98 ± 31% using a 100 HU threshold. Thresholding allowed better recovery with less variation and dependency on the volume of interest compared to the subtraction of a single HU reference value. Corresponding doses and histograms were successfully generated.</p><p><strong>Conclusion: </strong>CT quantification and dosimetry of <sup>166</sup>Ho should be considered for further clinical application with on-site validation using radioactive measurements and intra-operative Ho-MS and dose visualizations.</p><p><strong>Relevance statement: </strong>Image-guided holmium-166 microbrachytherapy currently lacks reliable quantification and dosimetry on CT to ensure treatment safety and efficacy, while it is the only imaging modality capable of quantifying high in vivo holmium concentrations.</p><p><strong>Key points: </strong>Local injection of <sup>166</sup>Ho-MS enables high local tumor doses while sparing surrounding tissue. CT enables imaging-based quantification and radiation-absorbed dose estimation of concentrated Ho in vivo, essential for treatment safety and efficacy. Two different CT scanners and multiple acquisition and reconstruction parameters showed near-perfect linearity between radiodensity and Ho concentration. The most accurate Ho recoveries on CT were 102 ± 11% in five phantoms and 98 ± 31% in seven canine patients using thresholding methods. Dose estimations and volume histograms were successfully implemented for clinical application using a dose point kern
背景:微近距离放射治疗通过在瘤内注射放射性钬-166 微球(166Ho-MS),使局部肿瘤剂量高,周围组织不受影响。磁共振成像(MRI)无法正确检测局部高浓度的钬-166MS,单光子发射计算机断层扫描的分辨率也不够高。计算机断层扫描(CT)速度更快,成本更低,分辨率高,以前也能进行 Ho 定量。我们的目标是优化 CT 的 Ho 定量,并实施相应的剂量测定:方法:使用模型和多种设置对两台扫描仪进行了Ho检测校准。使用减法和阈值对五个模型和七名犬类患者进行了定量评估,包括靶组织、注射量、采集参数和定量体积的影响。辐射吸收剂量的估算是通过蒙特卡罗模拟生成的三维 166Ho 特定剂量点核来实现的:CT校准显示,在所有条件下,放射密度(HU)和Ho浓度之间的线性关系接近完美,但扫描仪之间存在差异。使用较低的管电压、软组织内核和无扫描仪检测限制时,校准过程中的 Ho 检测率较高。使用平均组织 HU + (2 × 标准偏差) 的阈值,模型中最准确的 Ho 恢复率为 102 ± 11%;使用 100 HU 的阈值,患者中最准确的 Ho 恢复率为 98 ± 31%。与减去单个 HU 参考值相比,阈值法能更好地恢复 HU 值,且变化较小,对相关容积的依赖性也较小。成功生成了相应的剂量和直方图:结论:166Ho 的 CT 定量和剂量测定应考虑进一步应用于临床,并使用放射性测量和术中 Ho-MS 及剂量可视化进行现场验证:目前,图像引导下的钬-166微近距离治疗缺乏可靠的CT量化和剂量测定,无法确保治疗的安全性和有效性,而CT是唯一能够量化体内高浓度钬的成像方式:要点:166Ho-MS 的局部注射可在局部肿瘤中产生高剂量,同时不损伤周围组织。CT可对体内高浓度钬进行成像量化和辐射吸收剂量估算,这对治疗的安全性和有效性至关重要。两种不同的 CT 扫描仪和多种采集与重建参数显示,放射密度与 Ho 浓度之间近乎完美的线性关系。使用阈值法,CT 上最准确的 Ho 恢复率在五个模型中为 102 ± 11%,在七名犬类患者中为 98 ± 31%。利用基于蒙特卡罗模拟的剂量点核,成功地将剂量估计和体积直方图应用于临床。
{"title":"Quantitative CT imaging and radiation-absorbed dose estimations of <sup>166</sup>Ho microspheres: paving the way for clinical application.","authors":"Chiron Morsink, Nienke Klaassen, Gerrit van de Maat, Milou Boswinkel, Alexandra Arranja, Robin Bruggink, Ilva van Houwelingen, Irene Schaafsma, Jan Willem Hesselink, Frank Nijsen, Bas van Nimwegen","doi":"10.1186/s41747-024-00511-8","DOIUrl":"https://doi.org/10.1186/s41747-024-00511-8","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Microbrachytherapy enables high local tumor doses sparing surrounding tissues by intratumoral injection of radioactive holmium-166 microspheres (&lt;sup&gt;166&lt;/sup&gt;Ho-MS). Magnetic resonance imaging (MRI) cannot properly detect high local Ho-MS concentrations and single-photon emission computed tomography has insufficient resolution. Computed tomography (CT) is quicker and cheaper with high resolution and previously enabled Ho quantification. We aimed to optimize Ho quantification on CT and to implement corresponding dosimetry.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Two scanners were calibrated for Ho detection using phantoms and multiple settings. Quantification was evaluated in five phantoms and seven canine patients using subtraction and thresholding including influences of the target tissue, injected amounts, acquisition parameters, and quantification volumes. Radiation-absorbed dose estimation was implemented using a three-dimensional &lt;sup&gt;166&lt;/sup&gt;Ho specific dose point kernel generated with Monte Carlo simulations.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;CT calibration showed a near-perfect linear relation between radiodensity (HU) and Ho concentrations for all conditions, with differences between scanners. Ho detection during calibration was higher using lower tube voltages, soft-tissue kernels, and without a scanner detection limit. The most accurate Ho recovery in phantoms was 102 ± 11% using a threshold of mean tissue HU + (2 × standard deviation) and in patients 98 ± 31% using a 100 HU threshold. Thresholding allowed better recovery with less variation and dependency on the volume of interest compared to the subtraction of a single HU reference value. Corresponding doses and histograms were successfully generated.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;CT quantification and dosimetry of &lt;sup&gt;166&lt;/sup&gt;Ho should be considered for further clinical application with on-site validation using radioactive measurements and intra-operative Ho-MS and dose visualizations.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Relevance statement: &lt;/strong&gt;Image-guided holmium-166 microbrachytherapy currently lacks reliable quantification and dosimetry on CT to ensure treatment safety and efficacy, while it is the only imaging modality capable of quantifying high in vivo holmium concentrations.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Key points: &lt;/strong&gt;Local injection of &lt;sup&gt;166&lt;/sup&gt;Ho-MS enables high local tumor doses while sparing surrounding tissue. CT enables imaging-based quantification and radiation-absorbed dose estimation of concentrated Ho in vivo, essential for treatment safety and efficacy. Two different CT scanners and multiple acquisition and reconstruction parameters showed near-perfect linearity between radiodensity and Ho concentration. The most accurate Ho recoveries on CT were 102 ± 11% in five phantoms and 98 ± 31% in seven canine patients using thresholding methods. Dose estimations and volume histograms were successfully implemented for clinical application using a dose point kern","PeriodicalId":36926,"journal":{"name":"European Radiology Experimental","volume":"8 1","pages":"116"},"PeriodicalIF":3.7,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11473764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Performance of dual-energy subtraction in contrast-enhanced mammography for three different manufacturers: a phantom study. 三家不同制造商在对比增强乳腺 X 射线摄影中的双能量减影性能:一项模型研究。
IF 3.7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-14 DOI: 10.1186/s41747-024-00516-3
Gisella Gennaro, Giulia Vatteroni, Daniela Bernardi, Francesca Caumo

Background: Dual-energy subtraction (DES) imaging is critical in contrast-enhanced mammography (CEM), as the recombination of low-energy (LE) and high-energy (HE) images produces contrast enhancement while reducing anatomical noise. The study's purpose was to compare the performance of the DES algorithm among three different CEM systems using a commercial phantom.

Methods: A CIRS Model 022 phantom, designed for CEM, was acquired using all available automatic exposure modes (AECs) with three CEM systems from three different manufacturers (CEM1, CEM2, and CEM3). Three studies were acquired for each system/AEC mode to measure both radiation dose and image quality metrics, including estimation of measurement error. The mean glandular dose (MGD) calculated over the three acquisitions was used as the dosimetry index, while contrast-to-noise ratio (CNR) was obtained from LE and HE images and DES images and used as an image quality metric.

Results: On average, the CNR of LE images of CEM1 was 2.3 times higher than that of CEM2 and 2.7 times higher than that of CEM3. For HE images, the CNR of CEM1 was 2.7 and 3.5 times higher than that of CEM2 and CEM3, respectively. The CNR remained predominantly higher for CEM1 even when measured from DES images, followed by CEM2 and then CEM3. CEM1 delivered the lowest MGD (2.34 ± 0.03 mGy), followed by CEM3 (2.53 ± 0.02 mGy) in default AEC mode, and CEM2 (3.50 ± 0.05 mGy). The doses of CEM2 and CEM3 increased by 49.6% and 8.0% compared with CEM1, respectively.

Conclusion: One system outperformed others in DES algorithms, providing higher CNR at lower doses.

Relevance statement: This phantom study highlighted the variability in performance among the DES algorithms used by different CEM systems, showing that these differences can be translated in terms of variations in contrast enhancement and radiation dose.

Key points: DES images, obtained by recombining LE and HE images, have a major role in CEM. Differences in radiation dose among CEM systems were between 8.0% and 49.6%. One DES algorithm achieved superior technical performance, providing higher CNR values at a lower radiation dose.

背景:双能量减影(DES)成像在对比增强乳腺X光摄影术(CEM)中至关重要,因为低能量(LE)和高能量(HE)图像的重组可增强对比度,同时减少解剖噪音。本研究的目的是使用商用模型比较 DES 算法在三种不同 CEM 系统中的性能:方法:使用三个不同制造商生产的三种 CEM 系统(CEM1、CEM2 和 CEM3),使用所有可用的自动曝光模式 (AEC) 采集专为 CEM 设计的 CIRS 022 型模型。每种系统/自动曝光模式都采集了三项研究,以测量辐射剂量和图像质量指标,包括测量误差的估计。在三次采集中计算出的平均腺体剂量(MGD)被用作剂量测定指标,而对比噪声比(CNR)则从LE和HE图像以及DES图像中获得,并被用作图像质量指标:平均而言,CEM1 的 LE 图像的 CNR 是 CEM2 的 2.3 倍,是 CEM3 的 2.7 倍。在 HE 图像中,CEM1 的 CNR 分别是 CEM2 和 CEM3 的 2.7 倍和 3.5 倍。即使从 DES 图像中测量,CEM1 的 CNR 仍主要较高,其次是 CEM2,然后是 CEM3。CEM1 的 MGD 最低(2.34 ± 0.03 mGy),其次是默认 AEC 模式下的 CEM3(2.53 ± 0.02 mGy)和 CEM2(3.50 ± 0.05 mGy)。与 CEM1 相比,CEM2 和 CEM3 的剂量分别增加了 49.6% 和 8.0%:结论:在 DES 算法中,一种系统的表现优于其他系统,能以较低的剂量提供较高的 CNR:这项模型研究强调了不同CEM系统所使用的DES算法之间的性能差异,表明这些差异可以转化为对比度增强和辐射剂量的变化:要点:通过重组 LE 和 HE 图像获得的 DES 图像在 CEM 中发挥着重要作用。CEM系统之间的辐射剂量差异在8.0%到49.6%之间。一种 DES 算法实现了卓越的技术性能,以较低的辐射剂量提供了较高的 CNR 值。
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引用次数: 0
3D ultrasound guidance for radiofrequency ablation in an anthropomorphic thyroid nodule phantom. 在拟人甲状腺结节模型中进行射频消融的三维超声引导。
IF 3.7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-14 DOI: 10.1186/s41747-024-00513-6
Tim Boers, Sicco J Braak, Wyger M Brink, Michel Versluis, Srirang Manohar

Background: The use of two-dimensional (2D) ultrasound for guiding radiofrequency ablation (RFA) of benign thyroid nodules presents limitations, including the inability to monitor the entire treatment volume and operator dependency in electrode positioning. We compared three-dimensional (3D)-guided RFA using a matrix ultrasound transducer with conventional 2D-ultrasound guidance in an anthropomorphic thyroid nodule phantom incorporated additionally with temperature-sensitive albumin.

Methods: Twenty-four phantoms with 48 nodules were constructed and ablated by an experienced radiologist using either 2D- or 3D-ultrasound guidance. Postablation T2-weighted magnetic resonance imaging scans were acquired to determine the final ablation temperature distribution in the phantoms. These were used to analyze ablation parameters, such as the nodule ablation percentage. Further, additional procedure parameters, such as dominant/non-dominant hand use, were recorded.

Results: Nonsignificant trends towards lower ablated volumes for both within (74.4 ± 9.1% (median ± interquartile range) versus 78.8 ± 11.8%) and outside of the nodule (0.35 ± 0.18 mL versus 0.45 ± 0.46 mL), along with lower variances in performance, were noted for the 3D-guided ablation. For the total ablation percentage, 2D-guided dominant hand ablation performed better than 2D-guided non-dominant hand ablation (81.0% versus 73.2%, p = 0.045), while there was no significant effect in the hand comparison for 3D-guided ablation.

Conclusion: 3D-ultrasound-guided RFA showed no significantly different results compared to 2D guidance, while 3D ultrasound showed a reduced variance in RFA. A significant reduction in operator-ablating hand dependence was observed when using 3D guidance. Further research into the use of 3D ultrasound for RFA is warranted.

Relevance statement: Using 3D ultrasound for thyroid nodule RFA could improve the clinical outcome. A platform that creates 3D data could be used for thyroid diagnosis, therapy planning, and navigational tools.

Key points: Twenty-four in-house-developed thyroid nodule phantoms with 48 nodules were constructed. RFA was performed under 2D- or 3D-ultrasound guidance. 3D- and 2D ultrasound-guided RFAs showed comparable performance. Real-time dual-plane imaging may offer an improved overview of the ablation zone and aid electrode positioning. Dominant and non-dominant hand 3D-ultrasound-guided RFA outcomes were comparable.

背景:使用二维(2D)超声引导甲状腺良性结节的射频消融(RFA)有其局限性,包括无法监测整个治疗体积和操作者对电极定位的依赖性。我们比较了在拟人甲状腺结节模型中使用矩阵超声换能器和传统二维超声引导的三维(3D)射频消融:方法:由一名经验丰富的放射科医生使用二维或三维超声引导,制作了24个模型,模型中有48个结节,并进行了消融。消融后的 T2 加权磁共振成像扫描用于确定模型中最终的消融温度分布。这些数据用于分析消融参数,如结节消融百分比。此外,还记录了其他手术参数,如惯用手/非惯用手的使用情况:结果:3D引导下的消融术在结节内(74.4±9.1%(中位数±四分位数间距)对78.8±11.8%)和结节外(0.35±0.18 mL对0.45±0.46 mL)的消融量均呈下降趋势,且性能差异较小。就总消融率而言,二维引导下的优势手消融效果优于二维引导下的非优势手消融(81.0% 对 73.2%,p = 0.045),而三维引导下的消融在手的比较中没有显著影响。使用三维引导时,操作者对消融手的依赖性明显降低。有必要对使用三维超声进行 RFA 进行进一步研究:使用三维超声进行甲状腺结节 RFA 可改善临床效果。创建三维数据的平台可用于甲状腺诊断、治疗计划和导航工具:要点:构建了 24 个内部开发的甲状腺结节模型,包含 48 个结节。RFA在二维或三维超声引导下进行。三维和二维超声引导下的RFA效果相当。实时双平面成像可提供更好的消融区概览并帮助电极定位。惯用手和非惯用手在三维超声引导下进行的射频消融术效果相当。
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引用次数: 0
CT-based body composition analysis and pulmonary fat attenuation volume as biomarkers to predict overall survival in patients with non-specific interstitial pneumonia. 以 CT 为基础的身体成分分析和肺脂肪衰减体积作为生物标志物,预测非特异性间质性肺炎患者的总生存率。
IF 3.7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-10-14 DOI: 10.1186/s41747-024-00519-0
Luca Salhöfer, Francesco Bonella, Mathias Meetschen, Lale Umutlu, Michael Forsting, Benedikt M Schaarschmidt, Marcel Opitz, Nikolas Beck, Sebastian Zensen, René Hosch, Vicky Parmar, Felix Nensa, Johannes Haubold

Background: Non-specific interstitial pneumonia (NSIP) is an interstitial lung disease that can result in end-stage fibrosis. We investigated the influence of body composition and pulmonary fat attenuation volume (CTpfav) on overall survival (OS) in NSIP patients.

Methods: In this retrospective single-center study, 71 NSIP patients with a median age of 65 years (interquartile range 21.5), 39 females (55%), who had a computed tomography from August 2009 to February 2018, were included, of whom 38 (54%) died during follow-up. Body composition analysis was performed using an open-source nnU-Net-based framework. Features were combined into: Sarcopenia (muscle/bone); Fat (total adipose tissue/bone); Myosteatosis (inter-/intra-muscular adipose tissue/total adipose tissue); Mediastinal (mediastinal adipose tissue/bone); and Pulmonary fat index (CTpfav/lung volume). Kaplan-Meier analysis with a log-rank test and multivariate Cox regression were used for survival analyses.

Results: Patients with a higher (> median) Sarcopenia and lower (< median) Mediastinal Fat index had a significantly better survival probability (2-year survival rate: 83% versus 71% for high versus low Sarcopenia index, p = 0.023; 83% versus 72% for low versus high Mediastinal fat index, p = 0.006). In univariate analysis, individuals with a higher Pulmonary fat index exhibited significantly worse survival probability (2-year survival rate: 61% versus 94% for high versus low, p = 0.003). Additionally, it was an independent risk predictor for death (hazard ratio 2.37, 95% confidence interval 1.03-5.48, p = 0.043).

Conclusion: Fully automated body composition analysis offers interesting perspectives in patients with NSIP. Pulmonary fat index was an independent predictor of OS.

Relevance statement: The Pulmonary fat index is an independent predictor of OS in patients with NSIP and demonstrates the potential of fully automated, deep-learning-driven body composition analysis as a biomarker for prognosis estimation.

Key points: This is the first study assessing the potential of CT-based body composition analysis in patients with non-specific interstitial pneumonia (NSIP). A single-center analysis of 71 patients with board-certified diagnosis of NSIP is presented Indices related to muscle, mediastinal fat, and pulmonary fat attenuation volume were significantly associated with survival at univariate analysis. CT pulmonary fat attenuation volume, normalized by lung volume, resulted as an independent predictor for death.

背景:非特异性间质性肺炎(NSIP非特异性间质性肺炎(NSIP)是一种可导致终末期纤维化的间质性肺病。我们研究了身体成分和肺脂肪衰减体积(CTpfav)对非特异性间质性肺炎患者总生存期(OS)的影响:在这项回顾性单中心研究中,纳入了 2009 年 8 月至 2018 年 2 月期间接受过计算机断层扫描的 71 例 NSIP 患者,中位年龄为 65 岁(四分位数间距为 21.5),女性 39 例(55%),其中 38 例(54%)在随访期间死亡。身体成分分析使用基于 nnU-Net 的开源框架进行。特征合并为肌少症(肌肉/骨骼);脂肪(总脂肪组织/骨骼);肌肥大症(肌间/肌内脂肪组织/总脂肪组织);纵隔(纵隔脂肪组织/骨骼);肺脂肪指数(CTpfav/肺容积)。生存分析采用卡普兰-梅耶分析和对数秩检验以及多变量考克斯回归:结果: Sarcopenia 值较高(大于中位数)的患者和 Sarcopenia 值较低的患者(结论:全自动身体成分分析仪为患者提供了一种新的分析方法:全自动的身体成分分析为NSIP患者提供了有趣的视角。肺脂肪指数是预测 OS 的独立指标:肺脂肪指数是NSIP患者OS的独立预测指标,证明了全自动、深度学习驱动的身体成分分析作为预后评估生物标志物的潜力:这是第一项评估基于 CT 的身体成分分析在非特异性间质性肺炎(NSIP)患者中应用潜力的研究。该研究对 71 名经委员会确诊为非特异性间质性肺炎的患者进行了单中心分析,结果显示,肌肉、纵隔脂肪和肺脂肪衰减体积相关指数与单变量分析中的生存率显著相关。根据肺容积归一化的 CT 肺脂肪衰减体积是预测死亡的独立指标。
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European Radiology Experimental
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