Aim: In this study, it was aimed to determine the seroprevalence of rubella in children aged 0-15, who was admitted to Ankara Training and Research Hospital Pediatric outpatient clinic for various reasons between December 2001 and July 2002. In this descriptive study, it is thought that knowing the seroprevalence before the national vaccination program will be important for the evaluation of the future data. Material and Method: In this descriptive study; the seroprevalence of rubella in 1170 children aged 0-15 years was investigated. The age, gender, socio-economic level and number of siblings of the 954 cases included in the study were recorded on the prepared forms, and the history of infection was taken from their families. Rubella specific IgG levels from serum samples of the cases were measured by using the RADIM rubella IgG EIA kit with Micro-ELISA technique. Results: The average age of the children included in the study was found to be 76 } 49 months. Considering their gender, 56.9% (n=543) were male and 43.1% (n=411) were female. Considering their socio-economic levels; 550 children were in the low-income group; 393 children were in the middle-income group and 11 children were in the high-income group. When the distributions are evaluated according to the number of siblings; 14% (n=134) of the cases were a single child, 45% (n=426) had one sibling, 28% (n=267) had two siblings, and 13% (n=127) of the cases had ≥ 3 siblings. When evaluated in terms of rubella seroprevalence, 47.2% (n=450) of the cases had negative rubella IgG and 52.8% (n=504) of them had positive rubella IgG. According to the age the seropositivity showed a significant increase with the increasing age and remained constant at around 91% in the 13-15 age range (p <0.05). Conclusion: This study, conducted before the National Immunization Program in 2003, showed that a large part of our population is vulnerable to the risk of rubella infection. Considering that the seroprevalence increases with age in order to prevent rubella infection, which affects women of reproductive age and congenital rubella syndrome (CRS) seen in newborns in particular, it is important to vaccinate all children who have completed their 12th month and have entered the 48th month within the scope of the national vaccination program. The data of this study will guide us in evaluating the success of the program in the population, we provide healthcare services in the following years, as it reflects the situation before the Expanded Immunization Program (EIP).
{"title":"The seroprevalence of rubella virus in children between 0-15 years old in a hospital in Ankara province before expanded immunization program","authors":"","doi":"10.51271/kmj-0010","DOIUrl":"https://doi.org/10.51271/kmj-0010","url":null,"abstract":"Aim: In this study, it was aimed to determine the seroprevalence of rubella in children aged 0-15, who was admitted to Ankara Training and Research Hospital Pediatric outpatient clinic for various reasons between December 2001 and July 2002. In this descriptive study, it is thought that knowing the seroprevalence before the national vaccination program will be important for the evaluation of the future data.\u0000Material and Method: In this descriptive study; the seroprevalence of rubella in 1170 children aged 0-15 years was investigated. The age, gender, socio-economic level and number of siblings of the 954 cases included in the study were recorded on the prepared forms, and the history of infection was taken from their families. Rubella specific IgG levels from serum samples of the cases were measured by using the RADIM rubella IgG EIA kit with Micro-ELISA technique.\u0000Results: The average age of the children included in the study was found to be 76 } 49 months. Considering their gender, 56.9% (n=543) were male and 43.1% (n=411) were female. Considering their socio-economic levels; 550 children were in the low-income group; 393 children were in the middle-income group and 11 children were in the high-income group. When the distributions are evaluated according to the number of siblings; 14% (n=134) of the cases were a single child, 45% (n=426) had one sibling, 28% (n=267) had two siblings, and 13% (n=127) of the cases had ≥ 3 siblings. When evaluated in terms of rubella seroprevalence, 47.2% (n=450) of the cases had negative rubella IgG and 52.8% (n=504) of them had positive rubella IgG. According to the age the seropositivity showed a\u0000significant increase with the increasing age and remained constant at around 91% in the 13-15 age range (p <0.05).\u0000Conclusion: This study, conducted before the National Immunization Program in 2003, showed that a large part of our population is vulnerable to the risk of rubella infection. Considering that the seroprevalence increases with age in order to prevent rubella infection, which affects women of reproductive age and congenital rubella syndrome (CRS) seen in newborns in particular, it is important to vaccinate all children who have completed their 12th month and have entered the 48th month within the scope of the national vaccination program. The data of this study will guide us in evaluating the success of the program in the population, we provide healthcare services in the following years, as it reflects the situation before the Expanded Immunization Program (EIP).","PeriodicalId":369732,"journal":{"name":"Kastamonu Medical Journal","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121417262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Coronary artery diseases and related clinical events are the most important causes of mortality and morbidity in the world. The diagnosis of coronary artery diseases is possible by knowing the coronary artery anatomy, embryology and histology. However, in terms of terms, anatomical names of coronary arteries differ clinically. In this article, anatomical structures on coronary angiography are presented with combining clinical terms.
{"title":"Combining the basically embryological, histological and anatomical structure of coronary arteries with the clinic","authors":"","doi":"10.51271/kmj-0014","DOIUrl":"https://doi.org/10.51271/kmj-0014","url":null,"abstract":"Coronary artery diseases and related clinical events are the most important causes of mortality and morbidity in the world. The diagnosis of coronary artery diseases is possible by knowing the coronary artery anatomy, embryology and histology. However, in terms of terms, anatomical names of coronary arteries differ clinically. In this article, anatomical structures on coronary angiography are presented with combining clinical terms.","PeriodicalId":369732,"journal":{"name":"Kastamonu Medical Journal","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133726897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: The rapid growth, morbidity and mortality of lung cancer and the lack of effective treatment have attracted great interest from researchers to find new cancer treatments aimed at the effect of gossypine on cell proliferation and apoptosis of A549 cells. The most used of these products are flavonoids. Gossypin is a potential chemo preventive and therapeutic agent for lung cancer. Material and Method: We investigated the effect of Gossypin anticancer activity on A549 cell proliferation with MTT method, depending on dose and time. In addition, mRNA expression levels of the apoptotic markers caspase-3 (CAS-3) and caspase-9 (CAS-9) were investigated by real-time PCR. In our study, six groups were used as control, gossypin (10, 20, 40 μM), cisplatin 5 μg/mL and cisplatin 5 μg/mL+gossypin 40 μM combine concentrations. The proliferative and antiapoptotic effects of gossypin at 24, 48 and 72 hours were investigated. Results were analyzed and presented as cell viability (%). Results: In our results, it was determined that gossypin especially at a dose of 40 μM and at 72 hours showed almost as much effect on A549 cells, but the highest inhibitory effect was seen in the 40 combined group of cisplatin 5 μg / mL + gossypin. In addition, gossypin caused a significant increase in apoptosis genes (CASP-3, CASP-9) compared to control. Conclusion: Our study showed that gossypin significantly increases the chemosensitivity of cisplatin. Based on this, it is predicted that gossypin can be used as a supportive therapy that increases the effectiveness of anticancer agents. However, more detailed research should be done for this.
{"title":"Investigation of antiproliferative effects of gossypin on lung cancer cell line","authors":"","doi":"10.51271/kmj-0009","DOIUrl":"https://doi.org/10.51271/kmj-0009","url":null,"abstract":"Purpose: The rapid growth, morbidity and mortality of lung cancer and the lack of effective treatment have attracted great interest from researchers to find new cancer treatments aimed at the effect of gossypine on cell proliferation and apoptosis of A549 cells. The most used of these products are flavonoids. Gossypin is a potential chemo preventive and therapeutic agent for lung cancer.\u0000Material and Method: We investigated the effect of Gossypin anticancer activity on A549 cell proliferation with MTT method, depending on dose and time. In addition, mRNA expression levels of the apoptotic markers caspase-3 (CAS-3) and caspase-9 (CAS-9) were investigated by real-time PCR. In our study, six groups were used as control, gossypin (10, 20, 40 μM), cisplatin 5 μg/mL and cisplatin 5 μg/mL+gossypin 40 μM combine concentrations. The proliferative and antiapoptotic effects of gossypin at 24, 48 and 72 hours were investigated. Results were analyzed and presented as cell viability (%).\u0000Results: In our results, it was determined that gossypin especially at a dose of 40 μM and at 72 hours showed almost as much effect on A549 cells, but the highest inhibitory effect was seen in the 40 combined group of cisplatin 5 μg / mL + gossypin. In addition, gossypin caused a significant increase in apoptosis genes (CASP-3, CASP-9) compared to control.\u0000Conclusion: Our study showed that gossypin significantly increases the chemosensitivity of cisplatin. Based on this, it is predicted that gossypin can be used as a supportive therapy that increases the effectiveness of anticancer agents. However, more detailed research should be done for this.","PeriodicalId":369732,"journal":{"name":"Kastamonu Medical Journal","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126859690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: In our study, the results of oral glucose tolerance test (OGTT) and other hemogram parameters of pregnant women with and without gestational diabetes mellitus (GDM) were compared. The aim of our study is to investigate the benefit of these parameters in predicting GDM risk. Material and Method: The study was planned as a descriptive, retrospective and cross-sectional study. It was included 218 pregnant women who applied to the Gynecology and Obstetrics Clinic of Amasya Sabuncuoğlu Şerefeddin Training and Research Hospital between January 01, 2019 and January 31, 2020. It was examined complete blood count parameters, ultrasound findings, complete urinalysis, first trimester blood glucose, body mass index, age, and gravide parameters the patients we included in the study. The results were analyzed retrospectively and was evaluated the statistical significance relationship with gestational diabetes. Results: There was no statistically significant difference in age, body mass index (BMI), obesity status and number of gravida between the pregnant women who were examined and those without GDM (p> 0.05). The hemoglobin, platelet count, mean platelet volume (MPV), mean corpuscular volume (MCV), mean corpuscular hemoglobine (MCH), and mean corpuscular hemoglobin concentration (MCHC) values, and neutrophil, lymphocyte, monocyte and basophil counts, urine density and femur length were statistically significant. There was no difference (p> 0.05). No statistically significant difference was found in terms of neutrophile lymphocyte ratio (NLR), neutrophile monocyte ratio (NMR), platelet lymphocyte ratio (PLR), monocyte eosinophil ratio (MER), platelet MPV ratio (PMPVR), and platelet neutrophile ratio (PNR) values (p> 0.05) Conclusion: HbA1c, hematocrit and blood glucose in the first trimester may be predictors of GDM. In addition, we think that further studies are needed in a prospective design in more patients in terms of others parameters.
{"title":"The role of the platelet profile in the prediction of gestational diabetes","authors":"","doi":"10.51271/kmj-0012","DOIUrl":"https://doi.org/10.51271/kmj-0012","url":null,"abstract":"Objective: In our study, the results of oral glucose tolerance test (OGTT) and other hemogram parameters of pregnant women with and without gestational diabetes mellitus (GDM) were compared. The aim of our study is to investigate the benefit of these parameters in predicting GDM risk.\u0000Material and Method: The study was planned as a descriptive, retrospective and cross-sectional study. It was included 218 pregnant women who applied to the Gynecology and Obstetrics Clinic of Amasya Sabuncuoğlu Şerefeddin Training and Research Hospital between January 01, 2019 and January 31, 2020. It was examined complete blood count parameters, ultrasound findings, complete urinalysis, first trimester blood glucose, body mass index, age, and gravide parameters the patients we included in the study. The results were analyzed retrospectively\u0000and was evaluated the statistical significance relationship with gestational diabetes.\u0000Results: There was no statistically significant difference in age, body mass index (BMI), obesity status and number of gravida between the pregnant women who were examined and those without GDM (p> 0.05). The hemoglobin, platelet count, mean platelet volume (MPV), mean corpuscular volume (MCV), mean corpuscular hemoglobine (MCH), and mean corpuscular hemoglobin concentration (MCHC) values, and neutrophil, lymphocyte, monocyte and basophil counts, urine density and femur length were statistically significant. There was no difference (p> 0.05). No statistically significant difference was found in terms of neutrophile lymphocyte ratio (NLR), neutrophile monocyte ratio (NMR), platelet lymphocyte ratio (PLR), monocyte eosinophil ratio (MER), platelet MPV ratio (PMPVR), and platelet neutrophile ratio (PNR) values (p> 0.05)\u0000Conclusion: HbA1c, hematocrit and blood glucose in the first trimester may be predictors of GDM. In addition, we think that further studies are needed in a prospective design in more patients in terms of others parameters.","PeriodicalId":369732,"journal":{"name":"Kastamonu Medical Journal","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133470984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: This study aims to investigate the relationship between serum uric acid levels, the left ventricular mass index (LVMI), and carotid intima-media thickness (CIMT) in primary hypertension patients. Material and Method: A total of 139 primary hypertension patients, including 45 (32.4%) men and 94 (67.6%) women were involved in the study. The laboratory and clinical demographic findings, as well as the LVMI and CIMT levels of the patients, were collected from patient files. Results: 37% of the study population were found to have hyperuricemia. LVMI (99.75}13.4 vs 86.17±17.6; p=0.010) and CIMT (0.88±0.26 vs 0.75±0.17; p=0.023) levels were found to be higher in the hyperuricemia versus the non-hyperuricemia group. According to the correlation analysis, there was a positive correlation between uric acid and LVMI (r=0.282, p=0.032) and CIMT (r=0.285, p=0.002) levels. Robust regression analysis showed that uric acid was an independent risk factor for both the LVMI (β±SE: 1.615±1.03, p<0.05) and CIMT (β±SE: 0.251±0.09, p<0.05). Conclusion: We found serum uric acid levels to be closely related to the target organ damage associated with primary hypertension, and even related with target organ damage independent from blood pressure.
背景:本研究旨在探讨原发性高血压患者血清尿酸水平、左心室质量指数(LVMI)和颈动脉内膜-中膜厚度(CIMT)之间的关系。材料与方法:共纳入139例原发性高血压患者，其中男性45例(32.4%)，女性94例(67.6%)。从患者档案中收集实验室和临床人口统计结果，以及患者的LVMI和CIMT水平。结果:37%的研究人群发现有高尿酸血症。LVMI (99.75}13.4 vs 86.17±17.6;p=0.010)和CIMT(0.88±0.26 vs 0.75±0.17;P =0.023)，发现高尿酸血症组的水平高于非高尿酸血症组。相关性分析显示，尿酸与LVMI (r=0.282, p=0.032)、CIMT (r=0.285, p=0.002)水平呈正相关。稳健回归分析显示，尿酸是LVMI (β±SE: 1.615±1.03,p<0.05)和CIMT (β±SE: 0.251±0.09,p<0.05)的独立危险因素。结论:我们发现血清尿酸水平与原发性高血压相关靶器官损害密切相关，甚至与独立于血压的靶器官损害相关。
{"title":"A predictive marker for target organ damage in primary hypertension: serum uric acid levels","authors":"","doi":"10.51271/kmj-0008","DOIUrl":"https://doi.org/10.51271/kmj-0008","url":null,"abstract":"Background: This study aims to investigate the relationship between serum uric acid levels, the left ventricular mass index (LVMI), and carotid intima-media thickness (CIMT) in primary hypertension patients.\u0000Material and Method: A total of 139 primary hypertension patients, including 45 (32.4%) men and 94 (67.6%) women were involved in the study. The laboratory and clinical demographic findings, as well as the LVMI and CIMT levels of the patients, were collected from patient files.\u0000Results: 37% of the study population were found to have hyperuricemia. LVMI (99.75}13.4 vs 86.17±17.6; p=0.010) and CIMT (0.88±0.26 vs 0.75±0.17; p=0.023) levels were found to be higher in the hyperuricemia versus the non-hyperuricemia group. According to the correlation analysis, there was a positive correlation between uric acid and LVMI (r=0.282, p=0.032)\u0000and CIMT (r=0.285, p=0.002) levels. Robust regression analysis showed that uric acid was an independent risk factor for both the LVMI (β±SE: 1.615±1.03, p<0.05) and CIMT (β±SE: 0.251±0.09, p<0.05).\u0000Conclusion: We found serum uric acid levels to be closely related to the target organ damage associated with primary hypertension, and even related with target organ damage independent from blood pressure.","PeriodicalId":369732,"journal":{"name":"Kastamonu Medical Journal","volume":"431 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132501657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The newly discovered myokine irisin has been proposed to affect physical activity. However, clinical and functional studies on the association of irisin with muscle mass, and metabolic status remain controversial. The nitric oxide is a molecule produced by the endothelium and in a variety of additional cells, including skeletal muscle. The aim of the study was to determine irisin and nitric oxide (NO) levels in physically inactive patients with severe acute metabolic disorders in intensive care unit. Material and Method: Total of 80 subjects were divided into 3 groups: healthy control (n=20), cerebrovascular disease (including hemi and paraplegic patients) (n=40), pulmonary disease (PD) (n=20). Plasma irisin levels were analyzed using a commercial ELISA kits. The total serum nitrate and nitrite was measured using a Nitrate/Nitrite Colorimetric Assay Kit. Results: We have found significantly higher irisin levels (322.8±20.4 ng/ml) in patients with cerebrovascular disease (p=0.0001) and (302.6±40.2 ng/ml) in patients with PD (p=0.01) compared to (171.4±10.5 ng/ml) control subjects. In addition, higher NO levels were observed (42.42±1.9 μM) in patients with cerebrovascular disease (p<0.001) and (44.36±2.7 μM) in patients with PD (p<0.001), compared to (27.65±0.7 μM) control subjects. Discussion: Observation of higher levels of irisin and NO in critically ill intensive care unit patients may indicate the protective roles of these agents against serious metabolic impairments.
{"title":"Determination of irisin and nitric oxide levels in patients with metabolic impairments in intensive care unit","authors":"","doi":"10.51271/kmj-0011","DOIUrl":"https://doi.org/10.51271/kmj-0011","url":null,"abstract":"Objective: The newly discovered myokine irisin has been proposed to affect physical activity. However, clinical and functional studies on the association of irisin with muscle mass, and metabolic status remain controversial. The nitric oxide is a molecule produced by the endothelium and in a variety of additional cells, including skeletal muscle. The aim of the study was to determine irisin and nitric oxide (NO) levels in physically inactive patients with severe acute metabolic disorders in intensive care unit.\u0000Material and Method: Total of 80 subjects were divided into 3 groups: healthy control (n=20), cerebrovascular disease (including hemi and paraplegic patients) (n=40), pulmonary disease (PD) (n=20). Plasma irisin levels were analyzed using a commercial ELISA kits. The total serum nitrate and nitrite was measured using a Nitrate/Nitrite Colorimetric Assay Kit.\u0000Results: We have found significantly higher irisin levels (322.8±20.4 ng/ml) in patients with cerebrovascular disease (p=0.0001) and (302.6±40.2 ng/ml) in patients with PD (p=0.01) compared to (171.4±10.5 ng/ml) control subjects. In addition, higher NO levels were observed (42.42±1.9 μM) in patients with cerebrovascular disease (p<0.001) and (44.36±2.7 μM) in patients with PD (p<0.001), compared to (27.65±0.7 μM) control subjects.\u0000Discussion: Observation of higher levels of irisin and NO in critically ill intensive care unit patients may indicate the protective roles of these agents against serious metabolic impairments.","PeriodicalId":369732,"journal":{"name":"Kastamonu Medical Journal","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128793257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Exercise is an important tool to stimulate oxidative stress and metabolic demands. We intended to evaluate impact of aerobic exercise on oxidative stress parameters and their relationships between irisin and nesfatin-1 levels. Material and Method: Total of ten healthy sedentary female subjects exercise for a 30 min of aerobic running exercise work intensity corresponded to associated their anaerobic threshold. Venous blood samples were taken before and at the end of the exercise. Serum irisin nesfatin-1 and TAS and TOS levels were analyzed using ELISA methods. Results: Exercise caused increase of irisin (11%) and nesfatin-1 (12%) levels. During exercise a decrease in TAS (-11%) and increased in TOS (29%) levels were observed. There was a significant correlation between changes of irisin and TAS levels (R=-0.67594, p=0.03). Conclusion: Consequently, exercise induced skeletal muscle activity may cause increase in oxidative stress, irisin and nesfatin-1 levels. Irisin hormone may be a secreted against to increased exercise-induced increased oxidative stress muscle activity.
{"title":"Effects of aerobic exercise induced oxidative stress on energy regulatory hormones of irisin and nesfatin-1 in healthy females","authors":"","doi":"10.51271/kmj-0002","DOIUrl":"https://doi.org/10.51271/kmj-0002","url":null,"abstract":"Objectives: Exercise is an important tool to stimulate oxidative stress and metabolic demands. We intended to evaluate impact of aerobic exercise on oxidative stress parameters and their relationships between irisin and nesfatin-1 levels. \u0000Material and Method: Total of ten healthy sedentary female subjects exercise for a 30 min of aerobic running exercise work intensity corresponded to associated their anaerobic threshold. Venous blood samples were taken before and at the end of the exercise. Serum irisin nesfatin-1 and TAS and TOS levels were analyzed using ELISA methods. \u0000Results: Exercise caused increase of irisin (11%) and nesfatin-1 (12%) levels. During exercise a decrease in TAS (-11%) and increased in TOS (29%) levels were observed. There was a significant correlation between changes of irisin and TAS levels (R=-0.67594, p=0.03). \u0000Conclusion: Consequently, exercise induced skeletal muscle activity may cause increase in oxidative stress, irisin and nesfatin-1 levels. Irisin hormone may be a secreted against to increased exercise-induced increased oxidative stress muscle activity.","PeriodicalId":369732,"journal":{"name":"Kastamonu Medical Journal","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123587467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The aim of this study is to investigate the role of the neutrophil-lymphocyte ratio (NLR) in the differential diagnosis of non-ST elevation myocardial infarction (NSTEMI) and unstable angina pectoris (USAP). Material and Method: Patients who had been admitted to the emergency ward with complaints of chest pain and who were diagnosed with USAP and NSTEMI in further examination were retrospectively included in this study. The NLR level was measured for each patient both at the times of application and of discharge. The NLR was calculated by dividing the neutrophil count by the lymphocyte count. Results: WBC (8107.38±1405.5 vs 7452.46±1427.9, p: 0.020), neutrophil (5620 vs 4300, p: 0.001), and NLR (3.86 vs 2.14, p: 0.001) values were higher, whereas the lymphocyte value (1505 vs 2100, p: 0.001) was lower in the NSTEMI versus the USAP group. According to the multivariable logistic regression analysis that was done, NLR appeared to be an independent predictor of NSTEMI. The predictive value of NLR for NSTEMI diagnosis was >3.22 with 61.9% sensitivity and 86.96% specificity (74.3% positive predictive, 78.9% negative predictive) (AUC: 0.761; p< 0.001). Conclusion: As a cheap inexpensive and easy-to-calculate index that can be applied in every medical establishment within the first 20 minutes of application, it is possible to state that NLR is a good marker in distinguishing NSTEMI from USAP patients.
背景:本研究旨在探讨中性粒细胞-淋巴细胞比值(NLR)在非st段抬高型心肌梗死(NSTEMI)和不稳定型心绞痛(USAP)鉴别诊断中的作用。材料和方法:本研究回顾性纳入了因胸痛主诉入住急诊科并经进一步检查诊断为USAP和NSTEMI的患者。在应用和出院时测量每位患者的NLR水平。NLR由中性粒细胞计数除以淋巴细胞计数计算。结果:与USAP组相比，NSTEMI组WBC(8107.38±1405.5 vs 7452.46±1427.9,p: 0.020)、中性粒细胞(5620 vs 4300, p: 0.001)和NLR (3.86 vs 2.14, p: 0.001)值较高，而淋巴细胞值(1505 vs 2100, p: 0.001)较低。根据所做的多变量logistic回归分析，NLR似乎是NSTEMI的独立预测因子。NLR对NSTEMI诊断的预测值为bb0.3.22，敏感性61.9%，特异性86.96%(阳性预测74.3%，阴性预测78.9%)(AUC: 0.761;p < 0.001)。结论:NLR作为一种价格低廉且易于计算的指标，可在应用前20分钟内应用于每个医疗机构，可以说是区分NSTEMI和USAP患者的良好指标。
{"title":"Is the neutrophil-lymphocyte ratio a good marker for the differential diagnosis of unstable angina pectoris and non-ST elevation myocardial infarction?","authors":"","doi":"10.51271/kmj-0004","DOIUrl":"https://doi.org/10.51271/kmj-0004","url":null,"abstract":"Background: The aim of this study is to investigate the role of the neutrophil-lymphocyte ratio (NLR) in the differential diagnosis of non-ST elevation myocardial infarction (NSTEMI) and unstable angina pectoris (USAP). \u0000Material and Method: Patients who had been admitted to the emergency ward with complaints of chest pain and who were diagnosed with USAP and NSTEMI in further examination were retrospectively included in this study. The NLR level was measured for each patient both at the times of application and of discharge. The NLR was calculated by dividing the neutrophil count by the lymphocyte count. \u0000Results: WBC (8107.38±1405.5 vs 7452.46±1427.9, p: 0.020), neutrophil (5620 vs 4300, p: 0.001), and NLR (3.86 vs 2.14, p: 0.001) values were higher, whereas the lymphocyte value (1505 vs 2100, p: 0.001) was lower in the NSTEMI versus the USAP group. According to the multivariable logistic regression analysis that was done, NLR appeared to be an independent predictor of NSTEMI. The predictive value of NLR for NSTEMI diagnosis was >3.22 with 61.9% sensitivity and 86.96% specificity (74.3% positive predictive, 78.9% negative predictive) (AUC: 0.761; p< 0.001). \u0000Conclusion: As a cheap inexpensive and easy-to-calculate index that can be applied in every medical establishment within the first 20 minutes of application, it is possible to state that NLR is a good marker in distinguishing NSTEMI from USAP patients.","PeriodicalId":369732,"journal":{"name":"Kastamonu Medical Journal","volume":"259 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117098151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: Exercise has great influence on increasing metabolic system functions. The work load corresponded to anaerobic threshold provide optimal aerobic strain for metabolic activity in exercising muscle. In the present study we intended to evaluate body substrate oxidation ratio during constant load exercise test at the intensity of anaerobic threshold in healthy young male subjects. Material and Method: Total of 15 male performed an incremental ramp exercise test to estimate anaerobic threshold. Standard V-slope method used to estimate anaerobic threshold. Then each subject performed a constant load exercise test for a 30 min period with a work load corresponded to their anaerobic threshold. Respiratory quotient (RQ) used to evaluate substrate oxidations during exercise. Anova test used to evaluate significance of data obtained every 5 minutes of constant load exercise. Results: The subjects’ anaerobic threshold occurred at approximately 63% of their maximal exercise capacity. RQ varied markedly among the subjects but as a mean value, but it systematically decreased with increasing exercise time. Body mass index and exercise time has great importance on fat and carbohydrate oxidation ratio. Conclusion: Exercise intensity at the anaerobic threshold provides meaningfully fat oxidation and could be acceptable in subjects with high body fat mass.
{"title":"Effects of exercise at the anaerobic threshold on respiratory quotient in young male subjects","authors":"","doi":"10.51271/kmj-0003","DOIUrl":"https://doi.org/10.51271/kmj-0003","url":null,"abstract":"Aim: Exercise has great influence on increasing metabolic system functions. The work load corresponded to anaerobic threshold provide optimal aerobic strain for metabolic activity in exercising muscle. In the present study we intended to evaluate body substrate oxidation ratio during constant load exercise test at the intensity of anaerobic threshold in healthy young male subjects. \u0000Material and Method: Total of 15 male performed an incremental ramp exercise test to estimate anaerobic threshold. Standard V-slope method used to estimate anaerobic threshold. Then each subject performed a constant load exercise test for a 30 min period with a work load corresponded to their anaerobic threshold. Respiratory quotient (RQ) used to evaluate substrate oxidations during exercise. Anova test used to evaluate significance of data obtained every 5 minutes of constant load exercise. \u0000Results: The subjects’ anaerobic threshold occurred at approximately 63% of their maximal exercise capacity. RQ varied markedly among the subjects but as a mean value, but it systematically decreased with increasing exercise time. Body mass index and exercise time has great importance on fat and carbohydrate oxidation ratio. \u0000Conclusion: Exercise intensity at the anaerobic threshold provides meaningfully fat oxidation and could be acceptable in subjects with high body fat mass.","PeriodicalId":369732,"journal":{"name":"Kastamonu Medical Journal","volume":"112 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126392261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Selfie-related behaviors which are accepted as only one of the results of social media addiction are known as selfie uploading, capturing selfie, sharing selfie, selfie posting and selfie editing and it also affects our daily life in every aspect. Neuro-behavioral studies which indicated the relationship between the behavior or addiction of heavy selfie takers and sharing them on social media and self-objectification, narcissism, and psychopathology have caused this current problem a syndrome feature such as a “Selfitis behaviors scale”. Screenagers-teenagers group constitutes a special risk group in selfie-related injuries and deaths owing to their high dynamic properties with especially in countries such as India where the adolescent population is high. Dangerous neurobehavioral acts related with problematic smartphone usage and selfie-related injuries are primarily associated with temporary distraction and the lack of self-awareness. Every behavior associated with many brain regions and it interacts each other in selfie-related behaviors. Through a multitude of afferent and efferent connections, prefrontal area is in mutual relationship with the other areas of cortex cerebri, namely thalamus, hypothalamus, basal ganglia, limbic system and cerebellum. We evaluated that the effects on adolescents of selfie-related behaviors with neurocognitive and behavioral perspective in this study.
{"title":"The neurocognitive basis of selfie-related behaviors in adolescents","authors":"","doi":"10.51271/kmj-0007","DOIUrl":"https://doi.org/10.51271/kmj-0007","url":null,"abstract":"Selfie-related behaviors which are accepted as only one of the results of social media addiction are known as selfie uploading, capturing selfie, sharing selfie, selfie posting and selfie editing and it also affects our daily life in every aspect. Neuro-behavioral studies which indicated the relationship between the behavior or addiction of heavy selfie takers and sharing them on social media and self-objectification, narcissism, and psychopathology have caused this current problem a syndrome feature such as a “Selfitis behaviors scale”. Screenagers-teenagers group constitutes a special risk group in selfie-related injuries and deaths owing to their high dynamic properties with especially in countries such as India where the adolescent population is high. Dangerous neurobehavioral acts related with problematic smartphone usage and selfie-related injuries are primarily associated with temporary distraction and the lack of self-awareness. Every behavior associated with many brain regions and it interacts each other in selfie-related behaviors. Through a multitude of afferent and efferent connections, prefrontal area is in mutual relationship with the other areas of cortex cerebri, namely thalamus, hypothalamus, basal ganglia, limbic system and cerebellum. We evaluated that the effects on adolescents of selfie-related behaviors with neurocognitive and behavioral perspective in this study.","PeriodicalId":369732,"journal":{"name":"Kastamonu Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129590200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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