Child health follow-up is the most important of basic health services and should continue at regular intervals until the age of 18 years. Physicians’ child health follow-up examinations present the best opportunity to deliver evidence-based preventive health services, such as monitoring the growth and development of the child, conducting age-appropriate screenings, providing vitamin/mineral support according to age and requirements, administering childhood vaccinations, informing the family about home accidents and nutrition, monitoring the child in terms of child neglect and abuse risks, and raising the awareness of the family in this regard. Child health follow-up should encompass not only children without any health problems but also those with mental, physical, visual, or hearing impairments, or special needs such as those with autism. Autism spectrum disorder is a neurodevelopmental disorder characterized by social and communication limitations and repetitive, restricted behaviors. The presence of a child with special needs such as autism can have social, psychological, and economic implications for family members. While there are many difficulties in caring for a healthy child, these difficulties increase exponentially in the care of a child with special needs. Professional assistance is necessary for families to address matters such as monitoring the child’s development, providing nourishment, and administering vaccinations. Children with autism constitute a group that needs to be closely followed up for vitamin-mineral deficiencies and growth retardation due to their higher risk of malnutrition. For these reasons, regular health follow-up of children with autism is essential at regular intervals.
{"title":"Health follow-up visits of children with autism","authors":"Ayşe Esra Tapci̇, Aysu Duyan Çamurdan","doi":"10.51271/kmj-0136","DOIUrl":"https://doi.org/10.51271/kmj-0136","url":null,"abstract":"Child health follow-up is the most important of basic health services and should continue at regular intervals until the age of 18 years. Physicians’ child health follow-up examinations present the best opportunity to deliver evidence-based preventive health services, such as monitoring the growth and development of the child, conducting age-appropriate screenings, providing vitamin/mineral support according to age and requirements, administering childhood vaccinations, informing the family about home accidents and nutrition, monitoring the child in terms of child neglect and abuse risks, and raising the awareness of the family in this regard. Child health follow-up should encompass not only children without any health problems but also those with mental, physical, visual, or hearing impairments, or special needs such as those with autism. Autism spectrum disorder is a neurodevelopmental disorder characterized by social and communication limitations and repetitive, restricted behaviors. The presence of a child with special needs such as autism can have social, psychological, and economic implications for family members. While there are many difficulties in caring for a healthy child, these difficulties increase exponentially in the care of a child with special needs. Professional assistance is necessary for families to address matters such as monitoring the child’s development, providing nourishment, and administering vaccinations. Children with autism constitute a group that needs to be closely followed up for vitamin-mineral deficiencies and growth retardation due to their higher risk of malnutrition. For these reasons, regular health follow-up of children with autism is essential at regular intervals.","PeriodicalId":369732,"journal":{"name":"Kastamonu Medical Journal","volume":" March","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140092815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ultrasonography (USG) is a non-invasive, portable, bedside, reproducible, radiation-free, inexpensive, and easily accessible imaging method. It provides morphological and functional information. It allows for diagnosis, monitoring, and guiding treatment. The usage areas of USG in the ICU are broad. In interventional procedures (thoracentesis, vascular interventions, percutaneous tracheostomy), evaluation of lung pathologies (pneumothorax, pleural effusion, pulmonary edema, consolidation, A-line, B line), diaphragm evaluation, abdominal imaging (trauma, kidney, liver), diagnosis and follow-up of deep vein thrombosis and the assessment and follow-up of fluid resuscitation (IVCI) and neuromonitoring. USG-guided neuromonitoring can detect stenosis or occlusion of intracranial arteries, monitor the development of patients with vasospasm after subarachnoid hemorrhage, detect cerebral embolism, evaluate the cerebral collateral system, and determine brain death. It can also indirectly calculate intracranial pressure (ICP) and cerebral perfusion under USG guidance.
{"title":"Ultrasound-guided neuromonitoring methods in the intensive care unit","authors":"U. Demir, Ö. Taşkın, Z. Doğanay","doi":"10.51271/kmj-0128","DOIUrl":"https://doi.org/10.51271/kmj-0128","url":null,"abstract":"Ultrasonography (USG) is a non-invasive, portable, bedside, reproducible, radiation-free, inexpensive, and easily accessible imaging method. It provides morphological and functional information. It allows for diagnosis, monitoring, and guiding treatment. The usage areas of USG in the ICU are broad. In interventional procedures (thoracentesis, vascular interventions, percutaneous tracheostomy), evaluation of lung pathologies (pneumothorax, pleural effusion, pulmonary edema, consolidation, A-line, B line), diaphragm evaluation, abdominal imaging (trauma, kidney, liver), diagnosis and follow-up of deep vein thrombosis and the assessment and follow-up of fluid resuscitation (IVCI) and neuromonitoring. USG-guided neuromonitoring can detect stenosis or occlusion of intracranial arteries, monitor the development of patients with vasospasm after subarachnoid hemorrhage, detect cerebral embolism, evaluate the cerebral collateral system, and determine brain death. It can also indirectly calculate intracranial pressure (ICP) and cerebral perfusion under USG guidance.","PeriodicalId":369732,"journal":{"name":"Kastamonu Medical Journal","volume":"20 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138965757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: Today, delivery is often performed as normal spontaneous vaginal delivery (NSVD) and cesarean section operations. Deliveries with NSVD mostly take place in the delivery room without the need for additional anesthetic agents. General anesthesia and regional anesthesia techniques are applied in cesarean section operations. In this study; The aim of this study was to examine the effect of general anesthesia on newborn bilirubin and to compare it with the bilirubin level of babies born without general anesthesia with NSVD method. Methods: Between March 2022 and September 2022, 152 patients over the age of 18 with term pregnancy NSVD and elective cesarean section without complications were randomly included in the study. Cases diagnosed with liver and biliary tract disease, systemic liver and biliary tract effective drug use, DCOOMBS( +) and Covid (+) clinics were excluded. Results: Of the patients included in our study, 75 (49.3%) were given general anesthesia and 77 (50.7%) delivered with NSVD without general anesthesia. It was determined that the first hour bilirubin and the fourth hour bilirubin values were significantly higher (p <0.05) in the general anesthesia group compared to the group that did not receive general anesthesia. In the group that did not receive general anesthesia, the APGAR 5th min score was found to be significantly (p <0.05) higher than the general anesthesia group. APGAR 1 min value did not differ significantly (p > 0.05) between the anesthesia-free and general anesthesia groups. Neonatal weight, head circumference, and infant height did not differ significantly between the groups that did not receive general anesthesia and those who did not receive general anesthesia (p> 0.05). Conclusion: Among the groups that did not receive general anesthesia and anesthesia; Bilirubin value was found to be higher among babies born by cesarean section under general anesthesia. It seems that it is more beneficial to avoid systemic effects as much as possible and to disseminate NSVD.
{"title":"The effect of general anesthesia applied during cesarean section on newborn bilirubin","authors":"Deniz Turan, A. Karayel","doi":"10.51271/kmj-0124","DOIUrl":"https://doi.org/10.51271/kmj-0124","url":null,"abstract":"Aims: Today, delivery is often performed as normal spontaneous vaginal delivery (NSVD) and cesarean section operations. Deliveries with NSVD mostly take place in the delivery room without the need for additional anesthetic agents. General anesthesia and regional anesthesia techniques are applied in cesarean section operations. In this study; The aim of this study was to examine the effect of general anesthesia on newborn bilirubin and to compare it with the bilirubin level of babies born without general anesthesia with NSVD method.\u0000Methods: Between March 2022 and September 2022, 152 patients over the age of 18 with term pregnancy NSVD and elective cesarean section without complications were randomly included in the study. Cases diagnosed with liver and biliary tract disease, systemic liver and biliary tract effective drug use, DCOOMBS( +) and Covid (+) clinics were excluded.\u0000Results: Of the patients included in our study, 75 (49.3%) were given general anesthesia and 77 (50.7%) delivered with NSVD without general anesthesia. It was determined that the first hour bilirubin and the fourth hour bilirubin values were significantly higher (p <0.05) in the general anesthesia group compared to the group that did not receive general anesthesia. In the group that did not receive general anesthesia, the APGAR 5th min score was found to be significantly (p <0.05) higher than the general anesthesia group. APGAR 1 min value did not differ significantly (p > 0.05) between the anesthesia-free and general anesthesia groups. Neonatal weight, head circumference, and infant height did not differ significantly between the groups that did not receive general anesthesia and those who did not receive general anesthesia (p> 0.05). \u0000Conclusion: Among the groups that did not receive general anesthesia and anesthesia; Bilirubin value was found to be higher among babies born by cesarean section under general anesthesia. It seems that it is more beneficial to avoid systemic effects as much as possible and to disseminate NSVD.","PeriodicalId":369732,"journal":{"name":"Kastamonu Medical Journal","volume":"24 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138965746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Babayiğit, N. Dereli, Zehra Baykal, Handan Güleç, Filiz Koç, M. Şahap, E. Horasanlı
Lung fungal infections are rare and carry a high risk of death in critically ill patients. Further investigations including radiological imaging are needed for differential diagnosis. In this article, we present a patient with a tumor-like shadow on chest X-ray and a mildly necrotic soft tissue mass of 4 cm in the first computed tomography (CT) examination of the thorax, who was therefore prediagnosed with Lung Cancer. Due to the poor general condition of the patient, his family did not accept further examinations for cancer. Approximately 40 days later, the patient was taken to the intensive care unit with the complaint of respiratory distress. The bronchial sample was negative for malignant cells and Candida Tropicalis was detected in cultures. The size of the mass decreased in CT controls after treatment with antifungal agents. We thought that the image on CT was due to Candida Tropicalis infection and regressed with antifungal treatment. In conclusion, we can conclude that pulmonary candidiasis may present with atypical radiological findings. Fungal infections should be kept in mind in the differential diagnosis of lung cancer in cases with confusing mass-like images.
肺部真菌感染十分罕见，在重症患者中死亡风险很高。鉴别诊断需要进一步检查，包括放射成像。在本文中，我们介绍了一名在胸部 X 光片上有肿瘤样阴影，并且在首次胸部计算机断层扫描（CT）检查中发现 4 厘米轻度坏死软组织肿块的患者，该患者因此被预先诊断为肺癌。由于患者全身状况不佳，其家人没有接受进一步的癌症检查。大约 40 天后，患者因呼吸困难被送入重症监护室。支气管样本中的恶性细胞呈阴性，培养液中检测到热带念珠菌。在使用抗真菌药物治疗后，CT 对照组中肿块的大小有所减小。我们认为，CT 上的图像是由于热带念珠菌感染所致，并在抗真菌治疗后消退。总之，我们可以得出结论，肺念珠菌病可能会出现不典型的影像学表现。在肺癌的鉴别诊断中，如果出现令人困惑的肿块样影像，应注意真菌感染。
{"title":"Pulmonary candidiasis presenting as tumor-like shadow","authors":"M. Babayiğit, N. Dereli, Zehra Baykal, Handan Güleç, Filiz Koç, M. Şahap, E. Horasanlı","doi":"10.51271/kmj-0129","DOIUrl":"https://doi.org/10.51271/kmj-0129","url":null,"abstract":"Lung fungal infections are rare and carry a high risk of death in critically ill patients. Further investigations including radiological imaging are needed for differential diagnosis. In this article, we present a patient with a tumor-like shadow on chest X-ray and a mildly necrotic soft tissue mass of 4 cm in the first computed tomography (CT) examination of the thorax, who was therefore prediagnosed with Lung Cancer. Due to the poor general condition of the patient, his family did not accept further examinations for cancer. Approximately 40 days later, the patient was taken to the intensive care unit with the complaint of respiratory distress. The bronchial sample was negative for malignant cells and Candida Tropicalis was detected in cultures. The size of the mass decreased in CT controls after treatment with antifungal agents. We thought that the image on CT was due to Candida Tropicalis infection and regressed with antifungal treatment. In conclusion, we can conclude that pulmonary candidiasis may present with atypical radiological findings. Fungal infections should be kept in mind in the differential diagnosis of lung cancer in cases with confusing mass-like images.","PeriodicalId":369732,"journal":{"name":"Kastamonu Medical Journal","volume":"19 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138965779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ümit Halıcı, İ. Karal, Hüseyin Ağırbaş, Atilla Kanca, Z. Doğanay
Aims: In this retrospective study, we aimed to presentour experiences with patients undergoing carotid endarterectomy (CEA) operations. Methods: Between January 2011 and January 2021, a total of 88 patients (27 female, 61 male, mean age; 68.9 ± 8.7 and 41-88 years old) who underwent CEA were included in the study.Patients' files were reviewed.Bilateral CEA was performed in 2 of the patients. The complaints and demographic characteristics of the patients are shown in Table 1 and Table 2, respectively. Coronary artery bypass grafting (CABG) was also performed in 10 (8 of them simultaneously and 2 of them 1 month later)of the patients. In one of these simultaneously operated patients, aortic valve replacement was performed in addition to CEA and CABG. On the other hand, the operation was terminated due to the development of intraoperative sudden cardiac arrest in 2 patients. Results: Polytetrafluoroethylene patch, biological patch, Dacron patch, and great saphenous vein patch were used in 1, 1, 3,and 40 patients, respectively, while the CEA site was primarily closed in 43 patients.Characteristic features ofthe CEA operations are shown in Table 3. Also, complications of CEA surgery are shown in Table 4.In-hospital mortality was detected in 3 patients. Conclusion: The early results of our CEA operations are in line with the literature.
{"title":"Our experiences with carotid artery endarterectomy operations","authors":"Ümit Halıcı, İ. Karal, Hüseyin Ağırbaş, Atilla Kanca, Z. Doğanay","doi":"10.51271/kmj-0123","DOIUrl":"https://doi.org/10.51271/kmj-0123","url":null,"abstract":"Aims: In this retrospective study, we aimed to presentour experiences with patients undergoing carotid endarterectomy (CEA) operations.\u0000Methods: Between January 2011 and January 2021, a total of 88 patients (27 female, 61 male, mean age; 68.9 ± 8.7 and 41-88 years old) who underwent CEA were included in the study.Patients' files were reviewed.Bilateral CEA was performed in 2 of the patients. The complaints and demographic characteristics of the patients are shown in Table 1 and Table 2, respectively. Coronary artery bypass grafting (CABG) was also performed in 10 (8 of them simultaneously and 2 of them 1 month later)of the patients. In one of these simultaneously operated patients, aortic valve replacement was performed in addition to CEA and CABG. On the other hand, the operation was terminated due to the development of intraoperative sudden cardiac arrest in 2 patients.\u0000Results: Polytetrafluoroethylene patch, biological patch, Dacron patch, and great saphenous vein patch were used in 1, 1, 3,and 40 patients, respectively, while the CEA site was primarily closed in 43 patients.Characteristic features ofthe CEA operations are shown in Table 3. Also, complications of CEA surgery are shown in Table 4.In-hospital mortality was detected in 3 patients. \u0000Conclusion: The early results of our CEA operations are in line with the literature.","PeriodicalId":369732,"journal":{"name":"Kastamonu Medical Journal","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138965884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: There are many factors that affect morbidity and mortality in COVID-19. Coagulopathy is thought to be one of the important mechanisms in COVID-19 mortality. In this study, it was aimed to investigate coagulation factors and their relationship with prognosis in COVID-19. Methods: Patients diagnosed with COVID-19 were retrospectively reviewed in our hospital. The patients' demographic data, laboratory data on admission to the hospital, intensive care admissions, and surveillance were recorded. Patients were divided into two groups; Group 1 is non-critical patients followed up in the clinic, Group 2 is critical patients who need treatment in the intensive care unit. Results: 403 patients followed up for COVID-19 were analyzed. It was determined that the average age of the patients in Group 1 was statistically significantly lower than those in Group 2. (1: 45.28 ± 15.31 vs. 2: 60.15 ± 15.72, respectively, p <0.001). It was observed that the rates of HT, DM, CHD, and COPD in Group 2 were statistically significantly higher than Group 1 (p <0.05). While APTT values were similar in both groups, D-Dimer values were significantly higher in Group 2. As QSOFA, SIC, DIC, and coagulation marker scores increased, the percentage of patients with death increased significantly (p <0.05). Age, HT, COPD, PT, and high fibrinogen levels were found to increase the mortality risk rates statistically (p <0.05). Conclusion: It was determined that the most important factors determining mortality in COVID-19 are COPD and HT. APTT and D-dimer values were not found to be a prognostic factor in terms of mortality. However, PT, fibrinogen, and age are poor prognostic factors and can be used to predict mortality requiring intensive care.
{"title":"Coagulation parameters and prognosis analysis in COVID-19 patients","authors":"Filiz Koç, M. Babayiğit","doi":"10.51271/kmj-0126","DOIUrl":"https://doi.org/10.51271/kmj-0126","url":null,"abstract":"Aims: There are many factors that affect morbidity and mortality in COVID-19. Coagulopathy is thought to be one of the important mechanisms in COVID-19 mortality. In this study, it was aimed to investigate coagulation factors and their relationship with prognosis in COVID-19.\u0000Methods: Patients diagnosed with COVID-19 were retrospectively reviewed in our hospital. The patients' demographic data, laboratory data on admission to the hospital, intensive care admissions, and surveillance were recorded. Patients were divided into two groups; Group 1 is non-critical patients followed up in the clinic, Group 2 is critical patients who need treatment in the intensive care unit.\u0000Results: 403 patients followed up for COVID-19 were analyzed. It was determined that the average age of the patients in Group 1 was statistically significantly lower than those in Group 2. (1: 45.28 ± 15.31 vs. 2: 60.15 ± 15.72, respectively, p <0.001). It was observed that the rates of HT, DM, CHD, and COPD in Group 2 were statistically significantly higher than Group 1 (p <0.05). While APTT values were similar in both groups, D-Dimer values were significantly higher in Group 2. As QSOFA, SIC, DIC, and coagulation marker scores increased, the percentage of patients with death increased significantly (p <0.05). Age, HT, COPD, PT, and high fibrinogen levels were found to increase the mortality risk rates statistically (p <0.05).\u0000Conclusion: It was determined that the most important factors determining mortality in COVID-19 are COPD and HT. APTT and D-dimer values were not found to be a prognostic factor in terms of mortality. However, PT, fibrinogen, and age are poor prognostic factors and can be used to predict mortality requiring intensive care.","PeriodicalId":369732,"journal":{"name":"Kastamonu Medical Journal","volume":"355 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138966580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Primary Sjogren's Syndrome(pSS) is a chronic autoimmune disease and focal lymphocytic infiltration of the exocrine glands is the key pathological feature (1). Polycythemia vera(PV) is a chronic myeloproliferative disorder characterized by JAK-2 mutations and increased red blood cell mass(2,3). Autoimmune diseases and hematological malignancies can often be observed together. Patients with SS are at a higher risk of developing lymphoproliferative diseases mainly low-grade B-cell lymphomas and predominantly marginal zone lymphoma. Moreover, PV can rarely be presented with paraneoplastic events including small vessel vasculitis (2). However, PV and pSS co-existence had never been reported. We here want to present a case of concurrently diagnosed PV and pSS.
{"title":"Concurrent diagnosis of Sjogren’s syndrome and polycthemia vera: a rare co-existence","authors":"Serkan Ünal, S. Kocaer","doi":"10.51271/kmj-0130","DOIUrl":"https://doi.org/10.51271/kmj-0130","url":null,"abstract":"Primary Sjogren's Syndrome(pSS) is a chronic autoimmune disease and focal lymphocytic infiltration of the exocrine glands is the key pathological feature (1). Polycythemia vera(PV) is a chronic myeloproliferative disorder characterized by JAK-2 mutations and increased red blood cell mass(2,3). Autoimmune diseases and hematological malignancies can often be observed together. Patients with SS are at a higher risk of developing lymphoproliferative diseases mainly low-grade B-cell lymphomas and predominantly marginal zone lymphoma. Moreover, PV can rarely be presented with paraneoplastic events including small vessel vasculitis (2). However, PV and pSS co-existence had never been reported. We here want to present a case of concurrently diagnosed PV and pSS.","PeriodicalId":369732,"journal":{"name":"Kastamonu Medical Journal","volume":"26 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138966197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Nursal, S. Yıgıt, Adem Keskin, Mehmet Kemal Tümer
Aims: The gender and age distribution of temporomandibular disorder (TMD) suggest a possible role for the female hormonal axis in the pathogenesis. The goal of this study was to evaluate if estrogen receptor (ESR1) gene variants contribute to TMD susceptibility in the Turkish population. Methods: A total of 270 people, 130 of whom were TMD patients and 140 healthy controls, were included in the study. The ESR1 PvuII (rs2234693) and Xbal (rs9340799) variants were genotyped using the polymerase chain reaction based restriction fragment length polymorphism (PCR-RFLP). The results were evaluated statistically. Results: There were 110 women (81.48%) and 25 men (18.52%) in the patient group. We found there was a significant association between rs2234693 T/C, C/C genotypes and TMD (p=0.007). Also, the C allele was more prevalent in patients compared to controls (p=0.002). A statistically significant association was observed when the patients were compared with the controls according to TT versus TC+CC (p=0.002). There was no statistical significance between the patient and control groups in terms of rs9340799 genotype and allele distribution. Then we evaluated the relationship between genotype distributions and clinical characteristics. Both males and females had the highest rs2234693 T/C genotype (p=0.049). The majority of people with bruxism, bruxomania, and bruxism plus bruxoma carried the rs2234693 T/C genotype (p=0.025). Conclusion: Our results showed that ESR1 rs2234693 might be associated with TMD risk in the Turkish population, but not rs9340799.
{"title":"ESR1 rs2234693 might be associated with TMD risk in the Turkish population, but not rs9340799","authors":"A. Nursal, S. Yıgıt, Adem Keskin, Mehmet Kemal Tümer","doi":"10.51271/kmj-0125","DOIUrl":"https://doi.org/10.51271/kmj-0125","url":null,"abstract":"Aims: The gender and age distribution of temporomandibular disorder (TMD) suggest a possible role for the female hormonal axis in the pathogenesis. The goal of this study was to evaluate if estrogen receptor (ESR1) gene variants contribute to TMD susceptibility in the Turkish population.\u0000Methods: A total of 270 people, 130 of whom were TMD patients and 140 healthy controls, were included in the study. The ESR1 PvuII (rs2234693) and Xbal (rs9340799) variants were genotyped using the polymerase chain reaction based restriction fragment length polymorphism (PCR-RFLP). The results were evaluated statistically.\u0000Results: There were 110 women (81.48%) and 25 men (18.52%) in the patient group. We found there was a significant association between rs2234693 T/C, C/C genotypes and TMD (p=0.007). Also, the C allele was more prevalent in patients compared to controls (p=0.002). A statistically significant association was observed when the patients were compared with the controls according to TT versus TC+CC (p=0.002). There was no statistical significance between the patient and control groups in terms of rs9340799 genotype and allele distribution. Then we evaluated the relationship between genotype distributions and clinical characteristics. Both males and females had the highest rs2234693 T/C genotype (p=0.049). The majority of people with bruxism, bruxomania, and bruxism plus bruxoma carried the rs2234693 T/C genotype (p=0.025).\u0000Conclusion: Our results showed that ESR1 rs2234693 might be associated with TMD risk in the Turkish population, but not rs9340799.\u0000","PeriodicalId":369732,"journal":{"name":"Kastamonu Medical Journal","volume":"360 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138966633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: In the earthquakes that took place in Kahramanmaraş on 06.02.2023, a large number of casualties and injuries were observed. Organizations and healthcare personnel providing healthcare services in the earthquake regions have significantly lost their functions and there have been disruptions in the provision of healthcare services. In this study, we analyzed the patients who applied due to being affected by the earthquake in Kastamonu, one of the provinces far from the epicenter of the earthquake. Methods: The records of 135 patients who admitted to Kastamonu Training and Research Hospital Emergency Medicine Clinic with the diagnosis of earthquake damage between 7-16 February 2023 were examined. They were divided into two groups: patients with trauma and other non-traumatic complaints. Demographic data, complaints, requested tests, final diagnoses, consultation and hospitalization status of the patients were recorded. Results: While 50 patients applied with complaints of trauma caused by the earthquake, 85 patients applied to the emergency department due to diseases other than trauma. 10 of these patients were hospitalized and the others were discharged. It was observed that soft tissue trauma was the most common diagnosis in applications for trauma reasons, and upper respiratory tract infection was the most common diagnosis for non-traumatic reasons. Conclusion: In our study, since we were a hospital far from the center of the earthquake, there were no patient applications on the first day, and since the patients arrived over the days, no problems arose during the triage and intervention stages.
{"title":"How much did the February 6 earthquakes affect a distant hospital?","authors":"Miraç Koç, Fatma Mutlu Kukul Güven","doi":"10.51271/kmj-0127","DOIUrl":"https://doi.org/10.51271/kmj-0127","url":null,"abstract":"Aims: In the earthquakes that took place in Kahramanmaraş on 06.02.2023, a large number of casualties and injuries were observed. Organizations and healthcare personnel providing healthcare services in the earthquake regions have significantly lost their functions and there have been disruptions in the provision of healthcare services. In this study, we analyzed the patients who applied due to being affected by the earthquake in Kastamonu, one of the provinces far from the epicenter of the earthquake.\u0000Methods: The records of 135 patients who admitted to Kastamonu Training and Research Hospital Emergency Medicine Clinic with the diagnosis of earthquake damage between 7-16 February 2023 were examined. They were divided into two groups: patients with trauma and other non-traumatic complaints. Demographic data, complaints, requested tests, final diagnoses, consultation and hospitalization status of the patients were recorded.\u0000Results: While 50 patients applied with complaints of trauma caused by the earthquake, 85 patients applied to the emergency department due to diseases other than trauma. 10 of these patients were hospitalized and the others were discharged. It was observed that soft tissue trauma was the most common diagnosis in applications for trauma reasons, and upper respiratory tract infection was the most common diagnosis for non-traumatic reasons.\u0000Conclusion: In our study, since we were a hospital far from the center of the earthquake, there were no patient applications on the first day, and since the patients arrived over the days, no problems arose during the triage and intervention stages.","PeriodicalId":369732,"journal":{"name":"Kastamonu Medical Journal","volume":"24 46","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138965716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ela Delikgöz Soykut, Nilgun Sahin, Eylem Odabasi, Donay Aksan, Ahmet Baran, Hatice Tataroglu
Aims: The incidence of brain metastases in patients with renal cell carcinoma (RCC) and malignant melanoma (MM) with radioresistant histologies is over 50%. Stereotactic radiodiosurgery (SRS) may be beneficial in treating radioresistant histologies. The effectiveness of SRS in terms of local control and survival rates in the treatment of patients with radioresistant brain metastases was the focus of our study. Methods: A retrospective review of RCC and MM brain metastases treated with SRS between 2013 and 2020 was conducted. Local control rates, distant brain metastases free survival, and overall survival (OS) were study endpoints. Results: 55 brain metastases were detected in 29 patients, 14 of whom were MM and 15 were RCC. The median follow-up time was 13 (1-89) months. The 1-y and 3-y actuarial local control rates were 82.4% and 59%, respectively. Increased size and volume of brain metastases were associated with progressive disease (p=0.041, p=0.002). Local control rates were increased in those receiving whole brain radiotherapy (WBRT) prior to SRS (0.008). The 1-y and 3-y distant brain metastases free survival were 87.7% and 60.2%, respectively, and increased in those receiving WBRT before SRS, but not statistically significant (p=0.403). The median OS was 8 months (HR: 1.79, 95% CI: 4.48-11.51). There was no difference in OS according to whether the primary disease diagnosis was RCC or MM (p=0.482). Patients with 1-2 brain metastases had better OS than patients with 3 or more brain metastases (p=0.029). Recursive partitioning analysis (RPA) and graded prognostic assessment (GPA) prognostic risk scores were significantly related to OS (p=0.001, p<0.001). OS worsened in patients who received WBRT before SRS compared to those who did not (0.035). OS increased statistically in patients who received immunotherapy (p=0.033). Conclusion: Improvement in local control was found in patients with small tumor diameter and volume. The addition of WBRT to the SRS increased both local control and distant brain metastasis free survival. Regarding OS, multiple metastases, high RPA score, and low GPA score worsened OS. Another crucial observation is that a positive predictive effect on OS was detected in patients in whom immunotherapy was combined with SRS.
{"title":"Results of stereotactic radiosurgery in the treatment of radioresistant brain metastases","authors":"Ela Delikgöz Soykut, Nilgun Sahin, Eylem Odabasi, Donay Aksan, Ahmet Baran, Hatice Tataroglu","doi":"10.51271/kmj-0112","DOIUrl":"https://doi.org/10.51271/kmj-0112","url":null,"abstract":"Aims: The incidence of brain metastases in patients with renal cell carcinoma (RCC) and malignant melanoma (MM) with radioresistant histologies is over 50%. Stereotactic radiodiosurgery (SRS) may be beneficial in treating radioresistant histologies. The effectiveness of SRS in terms of local control and survival rates in the treatment of patients with radioresistant brain metastases was the focus of our study. Methods: A retrospective review of RCC and MM brain metastases treated with SRS between 2013 and 2020 was conducted. Local control rates, distant brain metastases free survival, and overall survival (OS) were study endpoints. Results: 55 brain metastases were detected in 29 patients, 14 of whom were MM and 15 were RCC. The median follow-up time was 13 (1-89) months. The 1-y and 3-y actuarial local control rates were 82.4% and 59%, respectively. Increased size and volume of brain metastases were associated with progressive disease (p=0.041, p=0.002). Local control rates were increased in those receiving whole brain radiotherapy (WBRT) prior to SRS (0.008). The 1-y and 3-y distant brain metastases free survival were 87.7% and 60.2%, respectively, and increased in those receiving WBRT before SRS, but not statistically significant (p=0.403). The median OS was 8 months (HR: 1.79, 95% CI: 4.48-11.51). There was no difference in OS according to whether the primary disease diagnosis was RCC or MM (p=0.482). Patients with 1-2 brain metastases had better OS than patients with 3 or more brain metastases (p=0.029). Recursive partitioning analysis (RPA) and graded prognostic assessment (GPA) prognostic risk scores were significantly related to OS (p=0.001, p<0.001). OS worsened in patients who received WBRT before SRS compared to those who did not (0.035). OS increased statistically in patients who received immunotherapy (p=0.033). Conclusion: Improvement in local control was found in patients with small tumor diameter and volume. The addition of WBRT to the SRS increased both local control and distant brain metastasis free survival. Regarding OS, multiple metastases, high RPA score, and low GPA score worsened OS. Another crucial observation is that a positive predictive effect on OS was detected in patients in whom immunotherapy was combined with SRS.","PeriodicalId":369732,"journal":{"name":"Kastamonu Medical Journal","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136100170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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