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Synthetic Organs For Transplant And Bio-mimicReactors For Process Intensification Using Nano-structured Micro-porous Materials 用纳米结构微孔材料制备移植器官及强化生物模拟反应器
Pub Date : 2011-07-14 DOI: 10.2495/EHR110331
E. Akay, Z. Okumuş, O. S. Yildirim, M. Bokhari, G. Akay
In order to achieve Process Intensification through monolithic micro-reactors in bioand chemical technology we examined the processing strategy in the human body, taking the liver as a typical organ. The macroand micro-architectural structure can be mimicked by using nano-structured micro-porous polymers which were used as support in tissue engineering and bioprocess intensification. It was shown that these materials could be used as bone transplant and they are integrated into the body. Their integration could be predicted through in vitro experiments. Metallic versions of these structures with a hierarchy of pore size were produced in order to obtain catalytic bioor chemical reactors operating at high temperature and/or pressure.
为了通过生物化学技术中的单片微反应器实现过程强化,我们以肝脏为典型器官,研究了人体的加工策略。利用纳米微孔聚合物可以模拟其宏观和微观结构,并将其作为组织工程和生物过程强化的载体。结果表明,这些材料可用于骨移植,并与人体相结合。它们的结合可以通过体外实验来预测。为了获得在高温和/或高压下工作的催化生物或化学反应器,生产了具有孔隙大小等级的这些结构的金属版本。
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引用次数: 0
Disaster management and generational complacency: five crucial lessons. 灾难管理和一代人的自满:五个关键教训。
Pub Date : 2011-07-14 DOI: 10.2495/EHR110071
E. Bianchi
The World has suffered major disasters in the last 24 months. What have we learnt from natural disasters in the past, and what can we do differently in the management of critical disasters to minimise their impact on life, property and the environment? From a realistic and practical perspective, this paper will challenge conference attendees to consider the relationship between historical events and generational complacency, a learning from history, in measures to manage disasters, from devastating floods (which regularly flood the major Australian state of Queensland and city of Brisbane), to bushfires in 2009 which killed almost 200 hundred people. Australia has a unique history of natural disasters, ranging from extremes in high temperature, to floods and cyclones. The impacts of these are highly destructive, and Australia, like some countries, has partly learnt from the past, and has developed extensive capability and strategic approaches for pre-empting and managing such events, lessons which have world wide application and benefit. Techniques for pre-planning as well as dealing with the aftermath of a disaster are critical in ensuring that the confidence of the public is restored and/or maintained to ensure the effective “normalisation” of communities post the disaster. A simple risk management philosophy will be proposed to define the 5 lessons to manage such disasters, which all too often are a victim of generational complacency resulting in ineffective emergency management. The paper will provide a summary of mistakes from the past, Australia’s current initiatives and techniques in addressing emergency needs, including prevention, communication, response and recovery. Conference delegates will Environmental Health and Biomedicine 69 www.witpress.com, ISSN 1743-3525 (on-line) WIT Transactions on Biomedicine and Health, Vol 15, © 2011 WIT Press doi:10.2495/EHR110071 gain a unique and valuable insight into learning from the past, and the pro-active disaster management processes and techniques which must be formalised and enabled into the future.
在过去的24个月里,世界遭受了重大灾难。我们从过去的自然灾害中学到了什么?在重大灾害的管理中,我们可以采取哪些不同的措施,以尽量减少它们对生命、财产和环境的影响?从现实和实际的角度来看,本文将挑战与会者考虑历史事件和世代自满之间的关系,从历史中吸取教训,在管理灾害的措施中,从毁灭性的洪水(经常淹没澳大利亚昆士兰州和布里斯班市)到2009年造成近200人死亡的森林大火。澳大利亚有着独特的自然灾害历史,从极端高温到洪水和飓风。这些事件的影响是极具破坏性的,澳大利亚同一些国家一样,部分地从过去吸取了教训,并发展了广泛的能力和战略办法,以预防和管理这类事件,这些经验教训在全世界都适用和有益。在确保恢复和/或维持公众的信心,以确保灾后社区的有效“正常化”方面,灾前规划和灾后处理技术至关重要。将提出一种简单的风险管理理念,以确定管理此类灾害的5个教训,这些灾害往往是世代自满导致应急管理无效的受害者。该文件将总结过去所犯的错误、澳大利亚目前在处理紧急需要方面的举措和技术,包括预防、沟通、应对和恢复。会议代表将在环境健康与生物医学69 www.witpress.com, ISSN 1743-3525(在线)WIT生物医学与健康交易,第15卷,©2011 WIT出版社doi:10.2495/EHR110071中获得独特而有价值的见解,了解从过去学习,以及必须正式确定并实现未来的主动灾害管理过程和技术。
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引用次数: 0
Indoor motion analysis of a subject wearing prosthesis for adaptive snowboarding 佩戴自适应滑雪板假体受试者的室内运动分析
Pub Date : 2011-07-14 DOI: 10.2495/EHR110311
L. Gastaldi, S. Pastorelli, M. Caramella, U. Dimanico
The growing popularity of adaptive snowboarding has motivated the designs of new prostheses for lower limb amputees. In the paper the biomechanics of an amputee subject wearing an energy-storing trans-femoral prosthesis for snowboarding is investigated. Experimental motion analysis lab tests were conducted by two expert surfers, an amputee and an able body subject, in order to compare the different behaviours. Results for the two subjects and for different working conditions are reported and analysed. A strong dependence of the prosthesis behaviour on working conditions, especially on working frequency, can be pointed out
自适应滑雪板的日益普及,促使人们为下肢截肢者设计新的假肢。本文研究了一名截肢者佩戴能量储存型股骨假体进行滑雪运动的生物力学。实验运动分析实验室测试由两名冲浪专家进行,一名截肢者和一名健全的身体受试者,以比较不同的行为。报告和分析了两种不同工作条件下的结果。可以指出,假体的行为强烈依赖于工作条件,特别是工作频率
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引用次数: 11
Thermal Comfort In Operating Rooms:A Case Study 手术室热舒适:一个案例研究
Pub Date : 2011-07-14 DOI: 10.2495/EHR110101
F. Patania, A. Gagliano, F. Nocera, A. Galesi
This paper focuses on thermal comfort in hospital operating rooms (ORs). Thermal comfort depends on several factors such as temperature conditions of the operating room, insulation of protective clothing, stress, rate of metabolism and safety mechanisms in the body to keep core temperature stable. The modification of any of these elements triggers defense mechanisms which in extreme cases may lead to serious disturbances in the body. The maintenance of recommended standards (ISO 7330) concerning thermal conditions in operating rooms ensures the highest possible physical capabilities of the personnel while providing maximum safety for the patients. The purpose of the present work is to report the results obtained during an experimental campaign carried out at the Umberto I Hospital in Enna in order to improve efficiency of HVAC installations to secure thermal comfort in the operating rooms.
本文对医院手术室的热舒适进行了研究。热舒适取决于几个因素,如手术室的温度条件、防护服的绝缘、压力、新陈代谢率和体内保持核心温度稳定的安全机制。这些元素的任何改变都会触发防御机制,在极端情况下可能导致身体严重紊乱。维持推荐标准(ISO 7330)关于手术室的热条件,确保人员的最高物理能力,同时为患者提供最大的安全。本报告的目的是报告在恩纳翁贝托第一医院进行的一项实验运动中获得的结果,该运动旨在提高暖通空调装置的效率,以确保手术室的热舒适。
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引用次数: 13
Assessment of diesel particulate matter exposure among underground mine workers 地下煤矿工人柴油机颗粒物暴露评价
Pub Date : 2011-07-14 DOI: 10.2495/EHR110021
D. Bertolatti, K. Rumchev, B. Mullins
Diesel motor emissions are a major source of ultrafine particles as research shows that the particulate fraction of diesel exhaust consists mainly of very small particles, which rapidly agglomerate to form clumps of particles with <1 μm aerodynamic size. Substantial scientific evidence supports that inhalation of emissions from diesel exhaust particulates is associated with a range of adverse health effects. Measurements have shown that underground miners can be exposed to over 100 times the typical environmental concentrations of diesel particulate matter (DPM) and over 10 times the concentration measured in other work environments where diesel engines are common. This paper reports personal and environmental exposures to DPM in an underground mine in Western Australia. The findings demonstrated that the DPM concentration exceeded the provisional 8-hour time weighted average exposure standard of 0.1 mg/m 3 for most of the assessed locations. The elemental analysis indicated high concentrations of silica and iron in DPM which could be potentially associated with some adverse health effects including respiratory illnesses and irritating effects. Thermal comfort underground was also assessed and the results showed non compliance with the standards of the American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE).
研究表明,柴油发动机排放的超细颗粒主要由非常小的颗粒组成,这些颗粒会迅速聚集形成小于1 μm气动尺寸的颗粒团块。大量科学证据支持,吸入柴油废气微粒排放物与一系列不利健康影响有关。测量表明,地下矿工暴露在柴油颗粒物质(DPM)的典型环境浓度的100倍以上,在柴油发动机常见的其他工作环境中测量的浓度的10倍以上。本文报道了西澳大利亚州一个地下矿井中DPM的个人和环境暴露情况。结果表明,大多数评估地点的DPM浓度超过了临时8小时时间加权平均暴露标准0.1 mg/m 3。元素分析表明,DPM中高浓度的二氧化硅和铁可能与一些不利的健康影响有关,包括呼吸系统疾病和刺激效应。对地下热舒适进行了评估,结果显示不符合美国采暖、制冷和空调工程师协会(ASHRAE)的标准。
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引用次数: 2
Allometry Displayed In The Case Of Response ToSingle Exposure To Arsine And Its Use In TheExtraction Of The 0% Lethal Level 单次接触砷的异速生长及其在提取0%致死水平中的应用
Pub Date : 2009-09-12 DOI: 10.2495/EHR090331
A. Guenda
The relation between the exposure response to toxic gases, such as arsine, and the exposure time is almost non linear in a large domain of time. This non linear behaviour is especially visible when closer to the 0% lethal level, or closer to the 100% lethal level. An allometric behaviour has been displayed between the linear extrapolated exposure time corresponding to the 0% lethal level and the time corresponding to the medium of the linearity domain at a given concentration. Different methods have been used when displaying this allometry in order to ensure validity and reliability.
对有毒气体(如砷)的暴露反应与暴露时间之间的关系在很大的时间范围内几乎是非线性的。当接近0%致死水平或接近100%致死水平时,这种非线性行为尤其明显。0%致死水平对应的线性外推暴露时间与给定浓度下线性域介质对应的时间之间显示出异速生长行为。为了保证异速生长的有效性和可靠性,在显示异速生长时采用了不同的方法。
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引用次数: 0
Size distribution and elemental composition of ultrafine and nanoparticles 超细颗粒和纳米颗粒的尺寸分布和元素组成
Pub Date : 2009-09-12 DOI: 10.2495/EHR090051
D. Bertolatti, K. Rumchev
A large body of epidemiological research has found an association between increased particulate air pollution and acute and chronic respiratory symptoms. One area of aerosol science that is currently of much interest, and is the focus of this article, is the formation of particles by combustion. Our major concern is with so-called “nanoparticles” (diameter less than 50 nm), which can be formed, for example, from diesel engine and can be associated with health effects. One of the objectives of this pilot study was to characterize the NanoMoudi Model 125B which a second generation micro-orifice uniform deposit impactor. This new equipment is designed for sampling atmospheric aerosols and also for diesel emission monitoring and analysis. As part of this study the concentrations of particles with different size including PM10, PM2.5, and PM1.0 were also measured at different locations away from busy road within Perth metropolitan area using TSI DustTrakTM 8520 Aerosol Particulate Monitor and TSI P-Trak 8525 Ultrafine Particle Counter. The results of the study showed that the NanoMoudi could be used to successfully collect and analyze fine and ultrafine particles including diesel particulates. Further to this, people who lived closer to busy roads were more likely to be exposed to higher concentrations of ultrafine particles which could be associated with adverse health effects.
大量流行病学研究发现,空气微粒污染加剧与急性和慢性呼吸道症状之间存在关联。气溶胶科学的一个领域,目前是非常感兴趣的,这是本文的重点,是颗粒的燃烧形成。我们主要关注的是所谓的“纳米颗粒”(直径小于50纳米),例如,它可以从柴油发动机中形成,并可能与健康影响有关。本试验研究的目的之一是表征NanoMoudi模型125B,这是第二代微孔均匀沉积冲击器。这种新设备是为大气气溶胶采样和柴油排放监测和分析而设计的。作为研究的一部分,我们还使用TSI DustTrakTM 8520气溶胶颗粒监测仪和TSI P-Trak 8525超细颗粒计数器在珀斯市区远离繁忙道路的不同地点测量了PM10、PM2.5和PM1.0等不同大小的颗粒浓度。研究结果表明,NanoMoudi可以成功地用于收集和分析包括柴油颗粒在内的细颗粒和超细颗粒。此外,住在繁忙道路附近的人更有可能接触到高浓度的超细颗粒,这可能会对健康产生不利影响。
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引用次数: 3
Air Pollutant Deposition Effect AndMorphological Change Of Cryptomeria JaponicaPollen During Its Transport In Urban AndMountainous Areas Of Japan 日本城市和山区空气污染物沉积效应及柳杉花粉运输过程中的形态变化
Pub Date : 2009-09-12 DOI: 10.2495/EHR090081
Qingyue Wang, X. Gong, Shinichi Nakamura, K. Kurihara, M. Suzuki, K. Sakamoto, M. Miwa, S. Lu
Morbidity due to Cryptomeria japonica pollinosis is increasing, especially in the urban areas of Japan. It represents a major health problem for most modern societies. The reasons for this increase might be the association of pollen with air pollutants. Hyper-reactivity tests are being conducted on mice and rats for allergic immune response. However, such tests cannot evaluate the deposition of pollen to the respiratory tract, because they force the animals to be immunized to pollen allergen mixed with air pollutants separately. The purpose of this study is to investigate how air pollutants deposit onto airborne Cryptomeria japonica pollen grains during the pollen-flying season between urban and mountainous areas, and to aid further bioreactivity and hypersensitive research. Suspended particulate matter (SPM), Cryptomeria japonica perigonium and pollen grains were collected to identify the deposition of air pollutants in an urban area, Saitama City, and in a mountainous area, Okuchichibu, during the pollen flying seasons. Ionic and metallic components of SPM and perigonium and pollen grains were analyzed. We found that crustal components (Al, Fe and Ti) tended to deposit on pollen perigonium. The amount of ionic components of particles (NO3, SO4 and NH4) and gaseous pollutants (NO2, SO2 and NH3) deposited on the perigonium and pollen grains were higher in the urban than in the mountainous areas, the results of which was proven by determination of gaseous Environmental Health Risk V 77 © 2009 WIT Press WIT Transactions on Biomedicine and Health, Vol 14, www.witpress.com, ISSN 1743-3525 (on-line) doi:10.2495/EHR090081 pollutants exposed to Cryptomeria japonica pollen. It is suggested that these phenomena may affect the pollinosis and therefore it is necessary to investigate implications on further bioreactivity and hypersensitive research.
日本柳杉花粉症的发病率正在上升,特别是在日本的城市地区。它代表了大多数现代社会的一个主要健康问题。这种增加的原因可能是花粉与空气污染物的联系。高反应性试验正在对小鼠和大鼠进行过敏性免疫反应试验。然而,这种测试不能评估花粉在呼吸道的沉积,因为它们迫使动物对混合空气污染物的花粉过敏原进行单独免疫。本研究的目的是研究城市和山区花粉飞行季节空气污染物如何沉积在空气中的柳杉花粉粒上,并为进一步的生物反应性和超敏性研究提供依据。在花粉飞行季节,对埼玉市市区和大chichibu山区的悬浮颗粒物(SPM)、柳杉(Cryptomeria japonica perigonium)和花粉颗粒进行了采集,以确定空气污染物的沉积情况。分析了SPM和花粉粒的离子和金属成分。我们发现地壳成分(Al, Fe和Ti)倾向于沉积在花粉囊上。大气环境健康风险V测定结果表明,城市地区沉积在花苞和花粉颗粒上的颗粒离子组分(NO3、SO4和NH4)和气态污染物(NO2、SO2和NH3)含量高于山区地区。这一结果通过气体环境健康风险V的测定得到了证实。©2009 WIT出版社,WIT生物医学与健康学报,第14卷,www.witpress.com, ISSN 1743-3525(在线)doi:10.2495/EHR090081。这些现象可能影响传粉,因此有必要进一步研究其生物反应性和超敏性研究的意义。
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引用次数: 11
Thermal Modelling Of The Human Eye ExposedTo Infrared Radiation Of 1064 Nm Nd:YAGAnd 2090 Nm Ho:YAG Lasers 人眼在1064 Nm Nd:YAG和2090 Nm Ho:YAG激光红外辐射下的热模拟
Pub Date : 2009-09-12 DOI: 10.2495/EHR090221
A. Peratta, D. Poljak
In the last few decades laser eye surgery has been implemented in various ophthalmic procedures. The most important issue with laser eye surgery is the estimation of temperature rise in eye tissues due to the absorption of high intensity laser radiation. The 2D model of the human eye, using the Finite Elements Method, is developed in order to study the temperature distribution in human eyes subjected to radiation by two infrared lasers, the 1064 nm Nd:YAG and the 2090 nm Ho:YAG laser. The mathematical model is based on the space–time dependent Pennes’ bioheat transfer equation supplemented with natural boundary condition equations for the cornea and the sclera. The results could prove to be useful in predicting the damage to intraocular tissues due to heating by infrared laser radiation.
在过去的几十年里,激光眼科手术在各种眼科手术中得到了应用。激光眼科手术最重要的问题是估计由于吸收高强度激光辐射而引起的眼组织温升。为了研究1064 nm Nd:YAG和2090 nm Ho:YAG两种红外激光器辐照下人眼的温度分布,采用有限元法建立了人眼二维模型。该数学模型以时空相关的Pennes生物传热方程为基础,辅以角膜和巩膜的自然边界条件方程。该结果可用于预测红外激光加热对眼内组织的损伤。
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引用次数: 7
Contents Of Natural Radium-226 And Lead-210In Foods Produced Within The Russian Territory 俄罗斯境内生产的食品中天然镭-226和铅-210的含量
Pub Date : 2009-09-12 DOI: 10.2495/EHR090261
N. Shandala, N. Novikova, A. Titov, A. Filonova, V. Seregin
Dynamical examination of contents of the observed natural radionuclides in prime foodstuffs demonstrated their relative stability. Generally, Pb and Ra specific activities in foodstuffs depend upon the food type and options of agriculture management. Many-year researches show that average specific activities of Pb and Ra for different foodstuffs vary over the range 0.04-0.15 Bq/kg and 0.02-0.08 Bq/kg. Soil dependence of Pb and Ra contents in foodstuffs has not been revealed. Taking into account the food patterns of the Russian population, the highest intake of Pb and Ra is due to ingestion of bread, meat and drinking water. Annual effective internal doses are about 50 μSv/a.
对主要食品中所观察到的天然放射性核素含量的动态检测表明它们的相对稳定性。一般来说,食品中铅和Ra的特定活性取决于食品类型和农业管理的选择。多年研究表明,不同食品中铅、Ra的平均比活度在0.04 ~ 0.15 Bq/kg和0.02 ~ 0.08 Bq/kg之间变化。食品中铅、Ra含量的土壤依赖性尚未发现。考虑到俄罗斯人口的食物模式,铅和Ra的最高摄入量是由于摄入面包、肉类和饮用水。年有效内剂量约为50 μSv/a。
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引用次数: 0
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WIT Transactions on Biomedicine and Health
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