Abstract Introduction The rock avalanches are a frequent and disruptive phenomenon in the Himalayas and other mountain chains. To minimize future losses, it is essential to investigate the engineering geological causative factors and mechanism of these mass wasting events. Study area The present work is aimed at assessing the failure mechanism of the disastrous 2014 Jure rock avalanche along Araniko Highway, Northern Nepal. The event had blocked the Sunkoshi River and blocked an economically significant route to China. Geotechnical properties and analysis Initially, rockmass characterization and intact strength attribute were determined for the site to classify the failure zone. The parameters measured and obtained from the field and laboratory were integrated into the analytical models to obtain a conclusive interpretation of the failure mechanism. Structural, kinematic, and key block theory analyses have been carried out for decipher the evolution of the failure zone. Results and discussion Rock mass was found to be of fair quality, however, the structural instabilities and the presence of water has led to a progressive failure. Movement of the key block and subsequent sliding of wedges and foot failure appears to be a possible failure mechanism. Conclusion The present research explores the contributory engineering geological aspects of the Jure rock avalanche. The investigation results can be used to tackle similar large scale rock avalanches in similar geological terrains and thus minimizing the losses.
{"title":"Engineering geological characteristics and failure mechanics of Jure rock avalanche, Nepal","authors":"Suman Panthee, Suman Dulal, Vishnu Himanshu Ratnam Pandey, Vikas Yadav, Prakash Kumar Singh, Ashutosh Kainthola","doi":"10.1186/s40677-023-00256-3","DOIUrl":"https://doi.org/10.1186/s40677-023-00256-3","url":null,"abstract":"Abstract Introduction The rock avalanches are a frequent and disruptive phenomenon in the Himalayas and other mountain chains. To minimize future losses, it is essential to investigate the engineering geological causative factors and mechanism of these mass wasting events. Study area The present work is aimed at assessing the failure mechanism of the disastrous 2014 Jure rock avalanche along Araniko Highway, Northern Nepal. The event had blocked the Sunkoshi River and blocked an economically significant route to China. Geotechnical properties and analysis Initially, rockmass characterization and intact strength attribute were determined for the site to classify the failure zone. The parameters measured and obtained from the field and laboratory were integrated into the analytical models to obtain a conclusive interpretation of the failure mechanism. Structural, kinematic, and key block theory analyses have been carried out for decipher the evolution of the failure zone. Results and discussion Rock mass was found to be of fair quality, however, the structural instabilities and the presence of water has led to a progressive failure. Movement of the key block and subsequent sliding of wedges and foot failure appears to be a possible failure mechanism. Conclusion The present research explores the contributory engineering geological aspects of the Jure rock avalanche. The investigation results can be used to tackle similar large scale rock avalanches in similar geological terrains and thus minimizing the losses.","PeriodicalId":37025,"journal":{"name":"Geoenvironmental Disasters","volume":"57 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136157096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-27DOI: 10.1186/s40677-023-00253-6
Shoulong Ma, Mingwei Zhang, Lu Ma, Zhuangcai Tian, Xue Li, Zhenhao Su, Sicheng Bian
Abstract Coal mining has a significant impact on the movement of the overburden, leading to potential safety hazards in the working face. In this paper, a similarity simulation experiment was conducted to investigate the migration of overburden during the mining process of a specific working face in the Liuzhuang Coal Mine located in southern China. Sand and gravel were used to simulate the geological environment of each rock stratum. The deformation of the stratum was monitored using strain gauges, the fracture and displacement changes of the overburden stratum were recorded using cameras, and the characteristics of roof collapse was monitored using infrared thermal imager. The experimental model fully simulated the situation of the working face, and the actual working face size was obtained by enlarging the model by 100 times. The experiment found that during the initial stage of mining, there was no significant subsidence of the roof. In the course of the advancement of the working face, the primary roof intermittently fractured behind the working face, with subsequent propagation of upper cracks in an upward direction. The overburden rock layer above the goaf experienced continuous compaction, leading to the gradual closure of the separation layer. Simultaneously, new cracks constantly emerged in front of the working face, resulting in the progressive stabilization of the height of the crack zone. The stress measurements at each point exhibit a pattern of initial increased, followed by decrease, and ultimately stabilization. By considering the stress variation law of the overburden rock, the stress changes in key layers of the bedrock during mining could be categorized into four zones: the stress stable zone, stress increasing zone, stress reducing zone, and compaction stable zone. During the initial phase of coal seam mining, the presence of rock layers provided support, resulting in minimal subsidence of the overburden rock. However, as the mining operation progressed, the disturbance force and collapse of the overburden rock leaded to further downward subsidence. When the working face reached the stop line, the collapsed overburden rock gradually consolidates, resulting in a deceleration of energy release and the formation of a pressure relief zone. Consequently, the overburden rock above the working face underwent a slight additional subsidence, reaching its maximum level. A short cantilever rock beam structure was formed in the experiment. This study will provide valuable reference for future coal mining and serve as a vital theoretical basis for roof control in deep coal seam mining.
{"title":"Experimental investigation on stress distribution and migration of the overburden during the mining process in deep coal seam mining","authors":"Shoulong Ma, Mingwei Zhang, Lu Ma, Zhuangcai Tian, Xue Li, Zhenhao Su, Sicheng Bian","doi":"10.1186/s40677-023-00253-6","DOIUrl":"https://doi.org/10.1186/s40677-023-00253-6","url":null,"abstract":"Abstract Coal mining has a significant impact on the movement of the overburden, leading to potential safety hazards in the working face. In this paper, a similarity simulation experiment was conducted to investigate the migration of overburden during the mining process of a specific working face in the Liuzhuang Coal Mine located in southern China. Sand and gravel were used to simulate the geological environment of each rock stratum. The deformation of the stratum was monitored using strain gauges, the fracture and displacement changes of the overburden stratum were recorded using cameras, and the characteristics of roof collapse was monitored using infrared thermal imager. The experimental model fully simulated the situation of the working face, and the actual working face size was obtained by enlarging the model by 100 times. The experiment found that during the initial stage of mining, there was no significant subsidence of the roof. In the course of the advancement of the working face, the primary roof intermittently fractured behind the working face, with subsequent propagation of upper cracks in an upward direction. The overburden rock layer above the goaf experienced continuous compaction, leading to the gradual closure of the separation layer. Simultaneously, new cracks constantly emerged in front of the working face, resulting in the progressive stabilization of the height of the crack zone. The stress measurements at each point exhibit a pattern of initial increased, followed by decrease, and ultimately stabilization. By considering the stress variation law of the overburden rock, the stress changes in key layers of the bedrock during mining could be categorized into four zones: the stress stable zone, stress increasing zone, stress reducing zone, and compaction stable zone. During the initial phase of coal seam mining, the presence of rock layers provided support, resulting in minimal subsidence of the overburden rock. However, as the mining operation progressed, the disturbance force and collapse of the overburden rock leaded to further downward subsidence. When the working face reached the stop line, the collapsed overburden rock gradually consolidates, resulting in a deceleration of energy release and the formation of a pressure relief zone. Consequently, the overburden rock above the working face underwent a slight additional subsidence, reaching its maximum level. A short cantilever rock beam structure was formed in the experiment. This study will provide valuable reference for future coal mining and serve as a vital theoretical basis for roof control in deep coal seam mining.","PeriodicalId":37025,"journal":{"name":"Geoenvironmental Disasters","volume":"7 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136317404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-19DOI: 10.1186/s40677-023-00251-8
Yu Huang, Wuwei Mao, Min Xiong, Yian Wang, Cuizhu Zhao, Zhengying He, Fawu Wang
Abstract The International Workshop on Seismic Design and Assessment for Resilience, Robustness and Sustainability of Slope Engineering was held on 13–15 January 2023 on line, focusing on the theme of “Seismic resilience of slope engineering and the concept of resilience-based seismic design (RBSD) for geological disaster prevention and control”. In this workshop, a number of keynote and invited lectures provided an international exchange platform for researchers, industrial engineers and students to share their research, engineering practice and exchange novel ideas on seismic resilience for slope engineering in a way of online. At the same time, during this workshop, technical committee of the ICGdR-TC1 also took this opportunity to hold a working meeting on cutting-edge and strategic issues, and released the Shanghai Declaration on slope engineering.
{"title":"Report on the international workshop on seismic design and assessment for resilience, robustness and sustainability of slope engineering, 13–15 January 2023, Shanghai, China","authors":"Yu Huang, Wuwei Mao, Min Xiong, Yian Wang, Cuizhu Zhao, Zhengying He, Fawu Wang","doi":"10.1186/s40677-023-00251-8","DOIUrl":"https://doi.org/10.1186/s40677-023-00251-8","url":null,"abstract":"Abstract The International Workshop on Seismic Design and Assessment for Resilience, Robustness and Sustainability of Slope Engineering was held on 13–15 January 2023 on line, focusing on the theme of “Seismic resilience of slope engineering and the concept of resilience-based seismic design (RBSD) for geological disaster prevention and control”. In this workshop, a number of keynote and invited lectures provided an international exchange platform for researchers, industrial engineers and students to share their research, engineering practice and exchange novel ideas on seismic resilience for slope engineering in a way of online. At the same time, during this workshop, technical committee of the ICGdR-TC1 also took this opportunity to hold a working meeting on cutting-edge and strategic issues, and released the Shanghai Declaration on slope engineering.","PeriodicalId":37025,"journal":{"name":"Geoenvironmental Disasters","volume":"142 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135730375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-13DOI: 10.1186/s40677-023-00254-5
Alfred Homère Ngandam Mfondoum, Pauline Wokwenmendam Nguet, Dieudonné Tchokona Seuwui, Jean Valéry Mefire Mfondoum, Henry Bang Ngenyam, Ibrahima Diba, Mesmin Tchindjang, Bertin Djiangoue, Ali Mihi, Sofia Hakdaoui, Roseline Batcha, Frédéric Chamberlain Lounang Tchatchouang, Igor Casimir Njombissie Petcheu, Luc Moutila Beni
Abstract Background The Cameroon Volcanic Line (CVL) is an oceanic-continental megastructure prone to geo-hazards, including landslide/mudslide, gully erosion and flash floods targeted in this paper. Recent geospatial practices advocated a multi-hazard analysis approach supported by artificial intelligence. This study proposes the Multi-Geoenvironmental Hazards Susceptibility (MGHS) tool, by combining Analytical Hierarchy Process (AHP) with Machine Learning (ML) over the North-Moungo perimeter (Littoral Region, Cameroon). Methods Twenty-four factors were constructed from satellite imagery, global geodatabase and fieldwork data. Multicollinearity among these factors was quantified using the tolerance coefficient (TOL) and variance inflation factor (VIF). The AHP coefficients were used to weigh the factors and produce a preliminary map per Geoenvironmental hazard through weighted linear combination (WLC). The sampling was conducted based on events records and analyst knowledge to proceed with classification using Google Earth Engine (GEE) cloud computing interface. Classification and Regression Trees (CART), Random Forest (RF) and Gradient Boosting Regression Trees (GBRT), were used as basic learners of the stacked hazard factors, whereas, Support Vector Regression (SVR), was used for a meta-learning. Results The rainfall was ranked as the highest triggering factor for all Geoenvironmental hazards according to AHP, with a coefficient of 1 , while the after-learning importance assessment was more varied. The area under receiver operating characteristic (AUROC/AUC) was always more than 0.96 , and F 1 -score is between [ 0.86–0.88 ] for basic classifiers. Landslides, gully erosion and flash floods showed different spatial distributions, confirming then their probability of co-occurrence. MGHS outputs clearly displayed two and three simultaneous occurrences. Finally, the human vulnerability assessed with population layer and SVR outputs showed that high human concentrations are also the most exposed, using the example of Nkongsamba’s extract. Conclusions Combining AHP with single learners, then a meta-learner, was efficient in modelling MGHS and related human vulnerability. Interactions among geo-environmental hazards are the next step and city councils are recommended to integrate results in the planning process.
{"title":"Stepwise integration of analytical hierarchy process with machine learning algorithms for landslide, gully erosion and flash flood susceptibility mapping over the North-Moungo perimeter, Cameroon","authors":"Alfred Homère Ngandam Mfondoum, Pauline Wokwenmendam Nguet, Dieudonné Tchokona Seuwui, Jean Valéry Mefire Mfondoum, Henry Bang Ngenyam, Ibrahima Diba, Mesmin Tchindjang, Bertin Djiangoue, Ali Mihi, Sofia Hakdaoui, Roseline Batcha, Frédéric Chamberlain Lounang Tchatchouang, Igor Casimir Njombissie Petcheu, Luc Moutila Beni","doi":"10.1186/s40677-023-00254-5","DOIUrl":"https://doi.org/10.1186/s40677-023-00254-5","url":null,"abstract":"Abstract Background The Cameroon Volcanic Line (CVL) is an oceanic-continental megastructure prone to geo-hazards, including landslide/mudslide, gully erosion and flash floods targeted in this paper. Recent geospatial practices advocated a multi-hazard analysis approach supported by artificial intelligence. This study proposes the Multi-Geoenvironmental Hazards Susceptibility (MGHS) tool, by combining Analytical Hierarchy Process (AHP) with Machine Learning (ML) over the North-Moungo perimeter (Littoral Region, Cameroon). Methods Twenty-four factors were constructed from satellite imagery, global geodatabase and fieldwork data. Multicollinearity among these factors was quantified using the tolerance coefficient (TOL) and variance inflation factor (VIF). The AHP coefficients were used to weigh the factors and produce a preliminary map per Geoenvironmental hazard through weighted linear combination (WLC). The sampling was conducted based on events records and analyst knowledge to proceed with classification using Google Earth Engine (GEE) cloud computing interface. Classification and Regression Trees (CART), Random Forest (RF) and Gradient Boosting Regression Trees (GBRT), were used as basic learners of the stacked hazard factors, whereas, Support Vector Regression (SVR), was used for a meta-learning. Results The rainfall was ranked as the highest triggering factor for all Geoenvironmental hazards according to AHP, with a coefficient of 1 , while the after-learning importance assessment was more varied. The area under receiver operating characteristic (AUROC/AUC) was always more than 0.96 , and F 1 -score is between [ 0.86–0.88 ] for basic classifiers. Landslides, gully erosion and flash floods showed different spatial distributions, confirming then their probability of co-occurrence. MGHS outputs clearly displayed two and three simultaneous occurrences. Finally, the human vulnerability assessed with population layer and SVR outputs showed that high human concentrations are also the most exposed, using the example of Nkongsamba’s extract. Conclusions Combining AHP with single learners, then a meta-learner, was efficient in modelling MGHS and related human vulnerability. Interactions among geo-environmental hazards are the next step and city councils are recommended to integrate results in the planning process.","PeriodicalId":37025,"journal":{"name":"Geoenvironmental Disasters","volume":"140 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135853952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-11DOI: 10.1186/s40677-023-00252-7
None Benazir, None Syamsidik, Yunita Idris, Nadri Pratama Putra
Abstract This paper reflects on the progress of tsunami preparedness in a coastal community in Aceh, Indonesia, nearly two decades after the catastrophic 2004 Indian Ocean Tsunami. The research employs a comprehensive approach to thoroughly evaluate and comprehend the community’s preparedness, its correlation with local perceptions of tsunami risk, and delves into the prevalence of tsunamis in the area, with a specific emphasis on the significant impact of the 2004 Indian Ocean Tsunami on the coastal community of Aceh. To investigate the community’s readiness and the potential impacts of tsunamis at the study site, tsunami simulations were performed using the shallow water equation within the COMCOT (Cornell Multi-grid Coupled Tsunami) model. These simulations assessed run-up and inundation scenarios, thereby providing justification for the potential tsunami impact in the area. Modelling the scenario of tsunami in the region is important to measure the potential impact and estimation time for community to prepare the evacuation plan. In addition to the numerical modeling, a mixed-method approach was employed, involving the distribution of questionnaires and conducting in-depth interviews with 150 respondents directly on-site. These assessments yielded valuable insights into community perspectives on tsunami risk and their preparedness measures. The findings contribute to the development of effective strategies for disaster management by integrating local knowledge, experiences, and socialization programs. The study emphasizes the significance of ongoing endeavors to enhance community preparedness and mitigate the consequences of tsunamis.
{"title":"Connecting community’s perspectives on tsunami risk to anticipated future tsunamis: a reflection from a progress of tsunami preparedness from a coastal community in Aceh-Indonesia after 19 years of the 2004 Indian Ocean Tsunami","authors":"None Benazir, None Syamsidik, Yunita Idris, Nadri Pratama Putra","doi":"10.1186/s40677-023-00252-7","DOIUrl":"https://doi.org/10.1186/s40677-023-00252-7","url":null,"abstract":"Abstract This paper reflects on the progress of tsunami preparedness in a coastal community in Aceh, Indonesia, nearly two decades after the catastrophic 2004 Indian Ocean Tsunami. The research employs a comprehensive approach to thoroughly evaluate and comprehend the community’s preparedness, its correlation with local perceptions of tsunami risk, and delves into the prevalence of tsunamis in the area, with a specific emphasis on the significant impact of the 2004 Indian Ocean Tsunami on the coastal community of Aceh. To investigate the community’s readiness and the potential impacts of tsunamis at the study site, tsunami simulations were performed using the shallow water equation within the COMCOT (Cornell Multi-grid Coupled Tsunami) model. These simulations assessed run-up and inundation scenarios, thereby providing justification for the potential tsunami impact in the area. Modelling the scenario of tsunami in the region is important to measure the potential impact and estimation time for community to prepare the evacuation plan. In addition to the numerical modeling, a mixed-method approach was employed, involving the distribution of questionnaires and conducting in-depth interviews with 150 respondents directly on-site. These assessments yielded valuable insights into community perspectives on tsunami risk and their preparedness measures. The findings contribute to the development of effective strategies for disaster management by integrating local knowledge, experiences, and socialization programs. The study emphasizes the significance of ongoing endeavors to enhance community preparedness and mitigate the consequences of tsunamis.","PeriodicalId":37025,"journal":{"name":"Geoenvironmental Disasters","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136063316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-28DOI: 10.1186/s40677-023-00250-9
Michael Nones, Yiwei Guo
Abstract Background Climate change and increasing anthropogenic pressure are two of the major drivers of increasing extreme events like droughts and floods. To deal with the increasing number of flooding events hitting Europe in the last few decades, around twenty years ago the European Commission started to develop ad-hoc legislation to reduce flood risk by mapping flood hazard and risk areas, such as the Directive 2007/60/EC on the Assessment and Management of Flood Risk. This Directive looks to identify regions where flood management strategies should be prioritized. Despite this holistic approach, flaws connected to the consideration of sediment transport and morphological changes in rivers exist, leading to potential underestimations of the impact of floods affecting active watercourses or areas subjected to frequent morphological changes. Results By discussing six examples related to European lowland and mountain watercourses affected by significant floods in the last 20 years, the present mini-review aims to provide additional evidence on the need for a rethinking of flood risk mapping, moving from a “clear water” perspective to a more integrated approach, where the interactions between all the fluvial components (water, sediment, biota, and humans) are adequately considered. Conclusions The examples reported here show the importance of considering sediment and wood in flood risk management, suggesting the need for integrating flood-related studies with other disciplines like geomorphology and ecohydrology.
{"title":"Can sediments play a role in river flood risk mapping? Learning from selected European examples","authors":"Michael Nones, Yiwei Guo","doi":"10.1186/s40677-023-00250-9","DOIUrl":"https://doi.org/10.1186/s40677-023-00250-9","url":null,"abstract":"Abstract Background Climate change and increasing anthropogenic pressure are two of the major drivers of increasing extreme events like droughts and floods. To deal with the increasing number of flooding events hitting Europe in the last few decades, around twenty years ago the European Commission started to develop ad-hoc legislation to reduce flood risk by mapping flood hazard and risk areas, such as the Directive 2007/60/EC on the Assessment and Management of Flood Risk. This Directive looks to identify regions where flood management strategies should be prioritized. Despite this holistic approach, flaws connected to the consideration of sediment transport and morphological changes in rivers exist, leading to potential underestimations of the impact of floods affecting active watercourses or areas subjected to frequent morphological changes. Results By discussing six examples related to European lowland and mountain watercourses affected by significant floods in the last 20 years, the present mini-review aims to provide additional evidence on the need for a rethinking of flood risk mapping, moving from a “clear water” perspective to a more integrated approach, where the interactions between all the fluvial components (water, sediment, biota, and humans) are adequately considered. Conclusions The examples reported here show the importance of considering sediment and wood in flood risk management, suggesting the need for integrating flood-related studies with other disciplines like geomorphology and ecohydrology.","PeriodicalId":37025,"journal":{"name":"Geoenvironmental Disasters","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135386742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-06DOI: 10.1186/s40677-023-00249-2
Alemayehu Letamo, B. Kavitha, T. P. Tezeswi
{"title":"Unified earthquake catalogue and mapping of Gutenberg–Richter parameters for the East African Rift System","authors":"Alemayehu Letamo, B. Kavitha, T. P. Tezeswi","doi":"10.1186/s40677-023-00249-2","DOIUrl":"https://doi.org/10.1186/s40677-023-00249-2","url":null,"abstract":"","PeriodicalId":37025,"journal":{"name":"Geoenvironmental Disasters","volume":"10 1","pages":"1-11"},"PeriodicalIF":4.8,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41449239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-23DOI: 10.1186/s40677-023-00248-3
A. El-Rayes, M. Arnous, E. Shendi, Mohamed H. Geriesh, Ranem A. Gharib
{"title":"Morphotectonic controls on hydro-environmental hazards in rift basins: a case study from Southern Suez Canal Province, Egypt","authors":"A. El-Rayes, M. Arnous, E. Shendi, Mohamed H. Geriesh, Ranem A. Gharib","doi":"10.1186/s40677-023-00248-3","DOIUrl":"https://doi.org/10.1186/s40677-023-00248-3","url":null,"abstract":"","PeriodicalId":37025,"journal":{"name":"Geoenvironmental Disasters","volume":" ","pages":"1-28"},"PeriodicalIF":4.8,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49257160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-25eCollection Date: 2023-10-01DOI: 10.1093/crocol/otad040
Karin Cerna, Dana Duricova, Martin Lukas, Martin Kolar, Nadezda Machkova, Veronika Hruba, Katarina Mitrova, Kristyna Kubickova, Marta Kostrejova, Jakub Jirsa, Kristyna Kastylova, Stepan Peterka, Gabriela Vojtechova, Milan Lukas
Background: A subcutaneous formulation of infliximab (IFX-SC) approved to treat patients with inflammatory bowel disease may offer improved efficacy versus intravenous infliximab.
Methods: Patients with refractory Crohn's disease (CD, n = 32) previously treated unsuccessfully with at least 2 biologics were treated with IFX-SC and followed from baseline at Week 0 (W0) to Week 30 (W30). The study's primary endpoint was the treatment's persistence at W30, while secondary goals included the analysis of serum infliximab trough levels (TL IFX), dynamics of anti-IFX antibodies (ATIs), and clinical, serum and fecal markers of CD activity during IFX-SC treatment.
Results: Midterm treatment persistence with the continuation of treatment after W30 was 53%. TL IFX median values showed rapid, significant upward dynamics and exceeded 15.5 μg/mL at W30, whereas median ATI levels significantly declined. Among ATI-negative patients at W0 (n = 15), only one showed IFX immunogenicity with newly developed ATIs at W30. Among ATI-positive patients at W0, ATI seroconversion from ATI-positive to ATI-negative status was observed in 10 of 17 patients (58.8%). Patients who had continued IFX-SC treatment at W30 showed significant decreases in C-reactive protein (P = .0341), fecal calprotectin (P = .0002), and Harvey-Bradshaw index (P = .0029) since W0.
Conclusions: Patients with refractory CD previously treated with at least 2 biologics exhibited clinically relevant improvement with IFX-SC, which showed less immunogenic potential than IFX-IV and highly stable TL IFX.
{"title":"Subcutaneous Infliximab in Refractory Crohn's Disease Patients: A Possible Biobetter?","authors":"Karin Cerna, Dana Duricova, Martin Lukas, Martin Kolar, Nadezda Machkova, Veronika Hruba, Katarina Mitrova, Kristyna Kubickova, Marta Kostrejova, Jakub Jirsa, Kristyna Kastylova, Stepan Peterka, Gabriela Vojtechova, Milan Lukas","doi":"10.1093/crocol/otad040","DOIUrl":"10.1093/crocol/otad040","url":null,"abstract":"<p><strong>Background: </strong>A subcutaneous formulation of infliximab (IFX-SC) approved to treat patients with inflammatory bowel disease may offer improved efficacy versus intravenous infliximab.</p><p><strong>Methods: </strong>Patients with refractory Crohn's disease (CD, <i>n</i> = 32) previously treated unsuccessfully with at least 2 biologics were treated with IFX-SC and followed from baseline at Week 0 (W0) to Week 30 (W30). The study's primary endpoint was the treatment's persistence at W30, while secondary goals included the analysis of serum infliximab trough levels (TL IFX), dynamics of anti-IFX antibodies (ATIs), and clinical, serum and fecal markers of CD activity during IFX-SC treatment.</p><p><strong>Results: </strong>Midterm treatment persistence with the continuation of treatment after W30 was 53%. TL IFX median values showed rapid, significant upward dynamics and exceeded 15.5 μg/mL at W30, whereas median ATI levels significantly declined. Among ATI-negative patients at W0 (<i>n</i> = 15), only one showed IFX immunogenicity with newly developed ATIs at W30. Among ATI-positive patients at W0, ATI seroconversion from ATI-positive to ATI-negative status was observed in 10 of 17 patients (58.8%). Patients who had continued IFX-SC treatment at W30 showed significant decreases in C-reactive protein (<i>P</i> = .0341), fecal calprotectin (<i>P</i> = .0002), and Harvey-Bradshaw index (<i>P =</i> .0029) since W0.</p><p><strong>Conclusions: </strong>Patients with refractory CD previously treated with at least 2 biologics exhibited clinically relevant improvement with IFX-SC, which showed less immunogenic potential than IFX-IV and highly stable TL IFX.</p>","PeriodicalId":37025,"journal":{"name":"Geoenvironmental Disasters","volume":"4 1","pages":"otad040"},"PeriodicalIF":1.4,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10640858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85085579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-13DOI: 10.1186/s40677-023-00247-4
S. Ma, M. Zhang, Lu Ma, Zhuangcai Tian, Xue Li, Zhenhao Su
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