Acute coronary syndromes (ACS) are common diseases and one of the most common causes of death in the world. The most feared ACS is ST segment elevation myocardial infarction (STEMI). Approximately 50% of STEMI patients have lesions in multivessel disease (MVD), and this is associated with poor outcomes. In this study, we aimed to evaluate prognostic nutritional index (PNI) in patients with STEMI and MVD. 1708 patients diagnosed with STEMI were included in the study. The patients' blood parameters, electrocardiography and echocardiography findings, coronary angiography images were recorded and calculations were made. The mean follow-up period was 38.8±10.3 months. The mean age of 1708 patients was 56.7±12.3 years, and 1370 (80.2) of the patients were male. Lower PNI was associated with MVD (+). Mortality was observed more in the MVD (+) group (p
{"title":"The Role of Prognostic Nutritional Index in Predicting Multivessel Disease in Patients with ST-Segment Elevation Myocardial Infarction","authors":"Emrah AKSAKAL, Oğuzhan BİRDAL","doi":"10.56766/ntms.1363559","DOIUrl":"https://doi.org/10.56766/ntms.1363559","url":null,"abstract":"Acute coronary syndromes (ACS) are common diseases and one of the most common causes of death in the world. The most feared ACS is ST segment elevation myocardial infarction (STEMI). Approximately 50% of STEMI patients have lesions in multivessel disease (MVD), and this is associated with poor outcomes. In this study, we aimed to evaluate prognostic nutritional index (PNI) in patients with STEMI and MVD. 1708 patients diagnosed with STEMI were included in the study. The patients' blood parameters, electrocardiography and echocardiography findings, coronary angiography images were recorded and calculations were made. The mean follow-up period was 38.8±10.3 months. The mean age of 1708 patients was 56.7±12.3 years, and 1370 (80.2) of the patients were male. Lower PNI was associated with MVD (+). Mortality was observed more in the MVD (+) group (p","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"128 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135919886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This study aims to assess Bisphenol-A levels in serum samples from preeclampsia patients and determine potential distinctions by comparing them against samples from healthy pregnant women
Material-Methods: This single-center prospective case-control study aimed to investigate the potential differences in serum Bisphenol-A (BPA) levels between pregnant patients diagnosed with preeclampsia and healthy pregnant women. The study encompassed two distinct groups: the study group consisted of 30 pregnant patients diagnosed with preeclampsia, while the control group included 30 healthy pregnant women matched in terms of gestational weeks and demographic characteristics, maintaining a 1:1 ratio. Serum samples were subjected to analysis using a BPA ELISA kit
Results: The study encompassed a total of 60 patients, who were categorized into two groups: preeclampsia (n=30) and control (n=30). Upon comparison of the BPA values between the two groups, no statistically significant difference was detected (p=0.579).
Conclusion: Clear-cut scientific evidence establishing a conclusive causal link between BPA and preeclampsia is still lacking. Further research is needed in this area
{"title":"Maternal Bisphenol A Levels in Patients Diagnosed with Preeclampsia: A Case-Control Study","authors":"Merve ALDIKAÇTIOĞLU TALMAÇ, Fırat ERSAN, İzel GÜNAY, Gülsen SENER, İbrahim POLAT, Nilüfer ÇETİNKAYA","doi":"10.56766/ntms.1344747","DOIUrl":"https://doi.org/10.56766/ntms.1344747","url":null,"abstract":"Objective: This study aims to assess Bisphenol-A levels in serum samples from preeclampsia patients and determine potential distinctions by comparing them against samples from healthy pregnant women
 Material-Methods: This single-center prospective case-control study aimed to investigate the potential differences in serum Bisphenol-A (BPA) levels between pregnant patients diagnosed with preeclampsia and healthy pregnant women. The study encompassed two distinct groups: the study group consisted of 30 pregnant patients diagnosed with preeclampsia, while the control group included 30 healthy pregnant women matched in terms of gestational weeks and demographic characteristics, maintaining a 1:1 ratio. Serum samples were subjected to analysis using a BPA ELISA kit
 Results: The study encompassed a total of 60 patients, who were categorized into two groups: preeclampsia (n=30) and control (n=30). Upon comparison of the BPA values between the two groups, no statistically significant difference was detected (p=0.579).
 Conclusion: Clear-cut scientific evidence establishing a conclusive causal link between BPA and preeclampsia is still lacking. Further research is needed in this area","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135635683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
It was aimed to investigate the ultrasonography (US) features of axillary COVID-19 immunization adenitis. Patients with axillary COVID-19 immunization adenitis detected between April 2021 and January 2022 were included. US features of the lymph nodes identified at the patient's initial US were all recorded. Radiological follow-up information and if exists pathology results were investigated. 104 immunization adenitis in the axilla following Covid-19 vaccine were detected. Only 18.3 percent had axillary pain or edema. Biopsy was recommended for 4 patients and follow-up was recommended for the other 100 patients. Core biopsy results were lymphoid tissue with focal micro-abscess formations, reactive lymphoid hyperplasia and plasma cell increase. All of the patients had a history of vaccination in the last 3 months. After immunization, initial US imaging was conducted mean 24-days later. The mean long and short axis were 22-mm and 13-mm, respectively. The mean long-short axes ratio was 2.2. The mean thickness of the cortex was 4.8-mm. The long and short axes of the lymph nodes in the first US and control examinations were compared statistically and they decreased in time. The hilum existed (96%). Elastography revealed soft features. The majority of the immunization adenitis are just enlarged benign-appearing lymph nodes. The majority were found during the extensive immunization campaign and were asymptomatic. Patients and their physicians should be aware of the vaccination and imaging evaluation of specific patient groups considering that these vaccinations will continue to be used for a while in the next years.
{"title":"Radiological Characteristics of Immunization Adenitis in the Axilla Following the Covid-19 Vaccine","authors":"Mustafa DÜGER, Abdulkadir EREN","doi":"10.56766/ntms.1341236","DOIUrl":"https://doi.org/10.56766/ntms.1341236","url":null,"abstract":"It was aimed to investigate the ultrasonography (US) features of axillary COVID-19 immunization adenitis. Patients with axillary COVID-19 immunization adenitis detected between April 2021 and January 2022 were included. US features of the lymph nodes identified at the patient's initial US were all recorded. Radiological follow-up information and if exists pathology results were investigated. 104 immunization adenitis in the axilla following Covid-19 vaccine were detected. Only 18.3 percent had axillary pain or edema. Biopsy was recommended for 4 patients and follow-up was recommended for the other 100 patients. Core biopsy results were lymphoid tissue with focal micro-abscess formations, reactive lymphoid hyperplasia and plasma cell increase. All of the patients had a history of vaccination in the last 3 months. After immunization, initial US imaging was conducted mean 24-days later. The mean long and short axis were 22-mm and 13-mm, respectively. The mean long-short axes ratio was 2.2. The mean thickness of the cortex was 4.8-mm. The long and short axes of the lymph nodes in the first US and control examinations were compared statistically and they decreased in time. The hilum existed (96%). Elastography revealed soft features. The majority of the immunization adenitis are just enlarged benign-appearing lymph nodes. The majority were found during the extensive immunization campaign and were asymptomatic. Patients and their physicians should be aware of the vaccination and imaging evaluation of specific patient groups considering that these vaccinations will continue to be used for a while in the next years.","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"327 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135635695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Can KOSE, Ahmet DEMİR, Kübra KARAKOLCU, Ebru ŞAHİN GÜLEÇ
Objective: Letrozole is an aromatase inhibitor which has been used for ovulation induction. Our aim is to evaluate the effectiveness of adding letrozole to gonadotropins in the early follicular phase of gonadotropin-releasing hormone antagonist (GnRH-a) protocol in patients with poor ovarian response who had failed in the preceding GnRH-a cycle.
Materials and Method: Ninety-eight patients with poor ovarian response who had previously failed GnRH-a cycle were included. Patients (n; 58) who were treated with letrozole plus gonadotropins (LzGA) were compared with patients (n; 40) who received gonadotropins (GT). The number of total oocytes retrieved, the number of MII oocytes and fertilized oocytes, fertilization and implantation ratios, the rate of cycle cancellation as well as clinical pregnancy and live birth rates
Results: The LzGA group had a significantly shorter duration of GnRH-a stimulation and higher progesterone level at trigger day (p=0.005, p=0.049 respectively). Although letrozole administration demonstrated lower estradiol levels at trigger day and the total dose of gonadotropins used were lower in LzGA group, this was statistically non-significant (p=0.13, p=0.13 respectively).
Conclusion: Adding letrozole to gonadotropins in GnRH-a protocol in patients with poor prognosis did not improve pregnancy outcomes. But it seems to decrease IVF costs by reducing the GnRH-antagonist and gonadotropin dosage.
{"title":"Gonadotropin Versus Gonadotropin/Letrozole Protocol in Previously Failed Antagonist Cycles in Patients with Low Prognosis","authors":"Can KOSE, Ahmet DEMİR, Kübra KARAKOLCU, Ebru ŞAHİN GÜLEÇ","doi":"10.56766/ntms.1347840","DOIUrl":"https://doi.org/10.56766/ntms.1347840","url":null,"abstract":"Objective: Letrozole is an aromatase inhibitor which has been used for ovulation induction. Our aim is to evaluate the effectiveness of adding letrozole to gonadotropins in the early follicular phase of gonadotropin-releasing hormone antagonist (GnRH-a) protocol in patients with poor ovarian response who had failed in the preceding GnRH-a cycle.
 Materials and Method: Ninety-eight patients with poor ovarian response who had previously failed GnRH-a cycle were included. Patients (n; 58) who were treated with letrozole plus gonadotropins (LzGA) were compared with patients (n; 40) who received gonadotropins (GT). The number of total oocytes retrieved, the number of MII oocytes and fertilized oocytes, fertilization and implantation ratios, the rate of cycle cancellation as well as clinical pregnancy and live birth rates
 Results: The LzGA group had a significantly shorter duration of GnRH-a stimulation and higher progesterone level at trigger day (p=0.005, p=0.049 respectively). Although letrozole administration demonstrated lower estradiol levels at trigger day and the total dose of gonadotropins used were lower in LzGA group, this was statistically non-significant (p=0.13, p=0.13 respectively).
 Conclusion: Adding letrozole to gonadotropins in GnRH-a protocol in patients with poor prognosis did not improve pregnancy outcomes. But it seems to decrease IVF costs by reducing the GnRH-antagonist and gonadotropin dosage.","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135635693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: To determine the incidence of obstetric massive blood transfusion in a tertiary center, to determine the characteristics of massive blood transfusion, its main causes and adverse outcomes in obstetric cases, thus trying to contribute to the creation of obstetric emergency plans.
Materials and methods: The results of 39 cases who underwent massive blood transfusion for obstetric indications were reviewed retrospectively. Demographic data of the cases (age, gravida, parity, body mass index), indications for hospitalization, vital signs during hospitalization, shock index, hemogram values and INR values, massive transfusion indications, transfused blood products (and in intensive care/intensive care units) from patient medical files. Length of hospital stay, reactions and complications related to massive transfusion were recorded.The cases who underwent obstetric massive blood transfusion were divided into 2 groups as low-risk pregnancy and high-risk pregnancy.The data were also compared between the 2 groups.
Results: The rate of massive blood transfusion was found to be 26 (12/4607) in 10000 pregnancies in low-risk pregnancies and 1.2% (27/2269) in high-risk pregnancies. Transfusion was started in 21 of 33 cases who underwent cesarean section due to massive bleeding that occurred intraoperatively. The time between the decision of transfusion due to obstetric hemorrhage and initiation of transfusion, and the vital signs and shock indices of the cases at the time of initiation of transfusion were similar between the groups (p>0.05). However, while the Hb and Htc levels were statistically lower in the low-risk group at the time of initiation of transfusion, the INR value was statistically higher in the high-risk group.
Conclusion: In massive obstetric hemorrhages, which is one of the most important causes of maternal mortality, application of surgical procedures (compression sutures, arter ligation or hysterectomy) combined with massive blood transfusion is life-saving.
{"title":"Incidence of obstetric massive blood transfusion and clinicial features: hospital-based study","authors":"İzzet ÖZGÜRLÜK, Hüseyin Levent KESKİN","doi":"10.56766/ntms.1348308","DOIUrl":"https://doi.org/10.56766/ntms.1348308","url":null,"abstract":"Aim: To determine the incidence of obstetric massive blood transfusion in a tertiary center, to determine the characteristics of massive blood transfusion, its main causes and adverse outcomes in obstetric cases, thus trying to contribute to the creation of obstetric emergency plans.
 Materials and methods: The results of 39 cases who underwent massive blood transfusion for obstetric indications were reviewed retrospectively. Demographic data of the cases (age, gravida, parity, body mass index), indications for hospitalization, vital signs during hospitalization, shock index, hemogram values and INR values, massive transfusion indications, transfused blood products (and in intensive care/intensive care units) from patient medical files. Length of hospital stay, reactions and complications related to massive transfusion were recorded.The cases who underwent obstetric massive blood transfusion were divided into 2 groups as low-risk pregnancy and high-risk pregnancy.The data were also compared between the 2 groups.
 Results: The rate of massive blood transfusion was found to be 26 (12/4607) in 10000 pregnancies in low-risk pregnancies and 1.2% (27/2269) in high-risk pregnancies. Transfusion was started in 21 of 33 cases who underwent cesarean section due to massive bleeding that occurred intraoperatively. The time between the decision of transfusion due to obstetric hemorrhage and initiation of transfusion, and the vital signs and shock indices of the cases at the time of initiation of transfusion were similar between the groups (p>0.05). However, while the Hb and Htc levels were statistically lower in the low-risk group at the time of initiation of transfusion, the INR value was statistically higher in the high-risk group.
 Conclusion: In massive obstetric hemorrhages, which is one of the most important causes of maternal mortality, application of surgical procedures (compression sutures, arter ligation or hysterectomy) combined with massive blood transfusion is life-saving.","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135635940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Serkan Ali AKARSU, Recep Hakkı KOCA, Aslıhan ÇAKIR CİHANGİROĞLU, Tutku Can ACISU, İbrahim Halil GÜNGÖR, Mustafa SÖNMEZ, Gaffari TÜRK, Seyfettin GÜR, Ali Doğan ÖMÜR, Harika Eylül ESMER DURUEL
Objectives;In this study, it was aimed to determine the effect of Epigallocatechin gallate (EGCG) on the cryopreservation of rabbit semen.
Material and metod; For this purpose, semen was collected from six male New Zealand rabbits. Collected semen were divided into 5 groups as control, 25 µM, 50 µM, 100 µM and 200 µM. Semen samples were reconstituted and frozen after adding EGCG. Frozen straws were then thawed.
Results; After freezing and thawing, total motility, progressive motility, and rate of fast and medium speed sperm were significantly higher in the 50 µM group than in the other groups. Static sperm ratio was found to be lower in the 50 µM group than in the other groups. When the flow cytometry results were examined, there was no statistical difference between the groups in terms of the ratio of dead and live sperm. However, the rate of dead sperm with acrosome damage was found to be the lowest in the 50 µM group. High mitochondrial membrane potential sperm ratio was found higher in 50 µM and 100 µM groups compared to other groups (p
{"title":"Determination of the Effect of Epigallocatechin Gallate on Oxidative Stress, Apoptosis and Sperm Quality in Rabbit Semen","authors":"Serkan Ali AKARSU, Recep Hakkı KOCA, Aslıhan ÇAKIR CİHANGİROĞLU, Tutku Can ACISU, İbrahim Halil GÜNGÖR, Mustafa SÖNMEZ, Gaffari TÜRK, Seyfettin GÜR, Ali Doğan ÖMÜR, Harika Eylül ESMER DURUEL","doi":"10.56766/ntms.1340936","DOIUrl":"https://doi.org/10.56766/ntms.1340936","url":null,"abstract":"Objectives;In this study, it was aimed to determine the effect of Epigallocatechin gallate (EGCG) on the cryopreservation of rabbit semen. 
 Material and metod; For this purpose, semen was collected from six male New Zealand rabbits. Collected semen were divided into 5 groups as control, 25 µM, 50 µM, 100 µM and 200 µM. Semen samples were reconstituted and frozen after adding EGCG. Frozen straws were then thawed. 
 Results; After freezing and thawing, total motility, progressive motility, and rate of fast and medium speed sperm were significantly higher in the 50 µM group than in the other groups. Static sperm ratio was found to be lower in the 50 µM group than in the other groups. When the flow cytometry results were examined, there was no statistical difference between the groups in terms of the ratio of dead and live sperm. However, the rate of dead sperm with acrosome damage was found to be the lowest in the 50 µM group. High mitochondrial membrane potential sperm ratio was found higher in 50 µM and 100 µM groups compared to other groups (p","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135637471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: This study aimed to determine the quality of chest compressions performed by lay rescuers assisted by a healthcare worker over the telephone and investigate the effect of metronome use or the Stayin’ Alive song on the quality of these chest compressions.
Material and Method: This study was conducted prospectively at the emergency department of a tertiary hospital. The lay rescuers were assisted by an emergency medicine specialist over the telephone to perform chest compressions using the CPR Lilly PRO+ simulator. Three groups were formed, and the same participants performed three cycles of chest compressions over the telephone for two minutes first without any external stimulus (Group 1), then using a metronome as an external stimulus (Group 2), and finally by listening to the Stayin’ Alive song as another external stimulus (Group 3). The obtained data were analyzed with IBM SPSS v. 23.0.
Results: There was no statistically significant difference between the three groups in terms of the target number of chest compressions (p=0.404). However, the compression depth and chest compression fraction statistically significantly differed between the groups (p
{"title":"Investigation of the Effect of Using a Metronome or Song on the Lay Rescuers' Quality of Chest Compressions","authors":"Fatma TORTUM, Erdal TEKİN","doi":"10.56766/ntms.1276064","DOIUrl":"https://doi.org/10.56766/ntms.1276064","url":null,"abstract":"Introduction: This study aimed to determine the quality of chest compressions performed by lay rescuers assisted by a healthcare worker over the telephone and investigate the effect of metronome use or the Stayin’ Alive song on the quality of these chest compressions.
 Material and Method: This study was conducted prospectively at the emergency department of a tertiary hospital. The lay rescuers were assisted by an emergency medicine specialist over the telephone to perform chest compressions using the CPR Lilly PRO+ simulator. Three groups were formed, and the same participants performed three cycles of chest compressions over the telephone for two minutes first without any external stimulus (Group 1), then using a metronome as an external stimulus (Group 2), and finally by listening to the Stayin’ Alive song as another external stimulus (Group 3). The obtained data were analyzed with IBM SPSS v. 23.0.
 Results: There was no statistically significant difference between the three groups in terms of the target number of chest compressions (p=0.404). However, the compression depth and chest compression fraction statistically significantly differed between the groups (p","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136129333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mustafa DÜGER, Gökhan KARAKURT, Ekrem SEYHAN, Mustafa BOLATKALE
Abstract
Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a common multifactorial disease which has heterogeneous pathogenesis. The most important risk factor is smoking. In addition to many pathogenic mechanisms taking part in inflammatory process, Our study group does research on the relation of COPD with single nucleotide gene polymorphism at ET-1 gene. In the current studies there being a high ratio of Endotelin-1 (ET-1) in BAL liquid of COPD cases made researchers think ET-1 may have an important role in pathogenesis of COPD.
Methods: This prospective case-control study included 89 patients admitted with COPD and 87 control patients. In our study, we search for the density of single nucleotide gene polymorphism (+134 insA/delA) in ET-1 gene in the 87 smoking COPD and 89 healthy cases. Allele ratio and genotype distribution, distribution amongst three genotype in the COPD patient and healthy control group was analyzed. In this study, for endothelin gene -3A/-4A (-138 insertion/deletion) polymorphism analysis, PCR-RFLP method was used.
Results: In comparison with the healthy group, the COPD group has higher ratio of ET-1 gene (+134 insA/delA) polymorphism (p< 0,001).
Conclusion: Endotelin-1 gene polymorphism (+134 insA/delA) significantly increased in the patients than healthy ones (p
{"title":"Endothelin-1 Gene Polymorphism in Chronic Obstructive Pulmonary Disease : A case-control study","authors":"Mustafa DÜGER, Gökhan KARAKURT, Ekrem SEYHAN, Mustafa BOLATKALE","doi":"10.56766/ntms.1331707","DOIUrl":"https://doi.org/10.56766/ntms.1331707","url":null,"abstract":"Abstract
 Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a common multifactorial disease which has heterogeneous pathogenesis. The most important risk factor is smoking. In addition to many pathogenic mechanisms taking part in inflammatory process, Our study group does research on the relation of COPD with single nucleotide gene polymorphism at ET-1 gene. In the current studies there being a high ratio of Endotelin-1 (ET-1) in BAL liquid of COPD cases made researchers think ET-1 may have an important role in pathogenesis of COPD. 
 Methods: This prospective case-control study included 89 patients admitted with COPD and 87 control patients. In our study, we search for the density of single nucleotide gene polymorphism (+134 insA/delA) in ET-1 gene in the 87 smoking COPD and 89 healthy cases. Allele ratio and genotype distribution, distribution amongst three genotype in the COPD patient and healthy control group was analyzed. In this study, for endothelin gene -3A/-4A (-138 insertion/deletion) polymorphism analysis, PCR-RFLP method was used. 
 Results: In comparison with the healthy group, the COPD group has higher ratio of ET-1 gene (+134 insA/delA) polymorphism (p< 0,001). 
 Conclusion: Endotelin-1 gene polymorphism (+134 insA/delA) significantly increased in the patients than healthy ones (p","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136129486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Hypertension is an important public health problem with high morbidity and mortality and seen in approximately 1 in 3 people all over the world. Hypertension can cause direct or indirect labor losses, but despite this, awareness in the society remains at low levels. This research was conducted to examine the awareness of hypertension in newly graduated medical school students.
Methods: There search is across-sectional descriptive study. The population of the study consisted of 55 students studying in the last year of XXX University Faculty of Medicine. For the study, a questionnaire consisting of 26 questions was sent to the students electronically (Google forms), which was prepared by there searcher and questioned the presence of hypertension risk factors in the participants, the knowledge and attitudes of the participants about the diagnosis and treatment of hypertension.
Results: 96,3% (n=53) of 55 people were reached. 43.4% (n=23) of the participants were female and 56.6% (n=30) were male. When the risk factors in the Turkish Hypertension Consensus Report were questioned among the participants, it was seen that the most common risk factor was having a stressful personality with 66% (n=35). 34% (n=18) of the participants had not had their blood pressure measured in the last 6 months. Only 3.8% (n=2) stated that they could completely manage a hypertension patient with their current knowledge. It was seen that the average of correct answers given by the participants to 6 information questions about hypertension was 3.55±1.21.
Conclusion: Although the theoretical knowledge of the participants is partially sufficient, it is a situation that should be questioned well what makes them think that they cannot follow up hypertension patients. This may be due to the fact that medical faculties do not give as much importance to practical education as theoretical courses. More emphasis should be placed on the follow-up of common diseases such as hypertension in medical education, and students should be trained on routine practical approaches.
{"title":"Knowledge and Attitudes of XXX University Medical Faculty Students in the Diagnosis and Treatment of Hypertension: A Cross-sectional Study","authors":"Ersan GÜRSOY, Mercan YAĞIZ","doi":"10.56766/ntms.1206520","DOIUrl":"https://doi.org/10.56766/ntms.1206520","url":null,"abstract":"Objective: Hypertension is an important public health problem with high morbidity and mortality and seen in approximately 1 in 3 people all over the world. Hypertension can cause direct or indirect labor losses, but despite this, awareness in the society remains at low levels. This research was conducted to examine the awareness of hypertension in newly graduated medical school students.
 
 Methods: There search is across-sectional descriptive study. The population of the study consisted of 55 students studying in the last year of XXX University Faculty of Medicine. For the study, a questionnaire consisting of 26 questions was sent to the students electronically (Google forms), which was prepared by there searcher and questioned the presence of hypertension risk factors in the participants, the knowledge and attitudes of the participants about the diagnosis and treatment of hypertension.
 
 Results: 96,3% (n=53) of 55 people were reached. 43.4% (n=23) of the participants were female and 56.6% (n=30) were male. When the risk factors in the Turkish Hypertension Consensus Report were questioned among the participants, it was seen that the most common risk factor was having a stressful personality with 66% (n=35). 34% (n=18) of the participants had not had their blood pressure measured in the last 6 months. Only 3.8% (n=2) stated that they could completely manage a hypertension patient with their current knowledge. It was seen that the average of correct answers given by the participants to 6 information questions about hypertension was 3.55±1.21.
 Conclusion: Although the theoretical knowledge of the participants is partially sufficient, it is a situation that should be questioned well what makes them think that they cannot follow up hypertension patients. This may be due to the fact that medical faculties do not give as much importance to practical education as theoretical courses. More emphasis should be placed on the follow-up of common diseases such as hypertension in medical education, and students should be trained on routine practical approaches.","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136129331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elif AYDIN, Yalçın DİCLE, Şerif KAÇTAŞ, Ali Furkan GÜMÜŞ
Objective: Although brucellosis is the most common zoonosis in the world, it remains an infectious disease that has not received sufficient attention. This study’s aim was to retrospectively examine the results of the Rose Bengal and Brucellacapt tests in serum samples from patients with a prior diagnosis of brucellosis sent to our laboratory in our province, a highly endemic area for brucellosis.
Materials and Methods: Between June 2019 and June 2021, 7827 serum samples sent to the public health laboratory with a provisional diagnosis of brucellosis were evaluated. The Rose Bengal and Brucellacapt test (Vircell, Spain) was used diagnose infection. Samples with antibody titer ≥1/160 were considered positive.
Results: Of the 7827 samples included in the study, 354 (4.6%) of the total 7677 serum samples tested were RBT positive, 118 (3.1%) of the 3776 samples tested were BCAP positive, and 118 (3.3%) of the 3626 samples tested were both RBT and BCAP positive. It was found that seropositivity significantly higher in female patients (p
{"title":"Detection of Human Brucellosis by Brucellacapt and Rose Bengal Test in the Endemic Area","authors":"Elif AYDIN, Yalçın DİCLE, Şerif KAÇTAŞ, Ali Furkan GÜMÜŞ","doi":"10.56766/ntms.1219271","DOIUrl":"https://doi.org/10.56766/ntms.1219271","url":null,"abstract":"Objective: Although brucellosis is the most common zoonosis in the world, it remains an infectious disease that has not received sufficient attention. This study’s aim was to retrospectively examine the results of the Rose Bengal and Brucellacapt tests in serum samples from patients with a prior diagnosis of brucellosis sent to our laboratory in our province, a highly endemic area for brucellosis.
 Materials and Methods: Between June 2019 and June 2021, 7827 serum samples sent to the public health laboratory with a provisional diagnosis of brucellosis were evaluated. The Rose Bengal and Brucellacapt test (Vircell, Spain) was used diagnose infection. Samples with antibody titer ≥1/160 were considered positive. 
 Results: Of the 7827 samples included in the study, 354 (4.6%) of the total 7677 serum samples tested were RBT positive, 118 (3.1%) of the 3776 samples tested were BCAP positive, and 118 (3.3%) of the 3626 samples tested were both RBT and BCAP positive. It was found that seropositivity significantly higher in female patients (p","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136129332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：