Objective :Minimally invasive surgeries have important advantages such as lower morbidity, shorter hospital stay, and earlier return to routine life. Robot-assisted laparoscopic surgery (RALS) plays a leading role in the development process of minimally invasive surgery. In this study, we compared patients with endometrial cancer who were operated with RALS and traditional laparoscopic surgery (TLS) methods in terms of processes related to anesthesia, such as peroperative fluid management and transfusion requirement, analgesic strategies, postoperative complications, duration of post-anesthesia care unit (PACU) and hospital stay
Materials and Methods: Patients with American Society of Anaesthesiologists (ASA) scores II-III, over the age of 18, who were operated for endometrial cancer by TLS or RALS methods between January 2020 and March 2022 were included in the study. Patients age, ASA score, duration of surgery, peroperative fluid management, transfusion requirement, urine output, bleeding, postoperative Visual Analogue Scale (VAS) scores, the PACU admission were obtained from the standard anesthesia record form and preoperative and postoperative hemoglobin (Hb) values, length of hospital stay were obtained from the electronic database of the hospital.
Results: Intravenous fluid input, bleeding and urine output during the operation were statistically lower in group RALS. While there was no difference between the preoperative Hb values of the two groups, the postoperative Hb values were significantly lower in the TLS group. Perioperative bleeding and fluid replacement are lesser and the hospital stay is shorter in RALS.
Conclusion: TLS and RALS, which are minimally invasive surgical methods, are used in the treatment of endometrial cancer. The idea that RALS is more costly than TLS should be reconsidered, as RALS reduces costs with less perioperative bleeding and fluid replacement and shorter hospital stay
{"title":"COST OF ROBOT-ASSİSTED LAPAROSCOPİC SURGERY İN ENDOMETRİAL CANCER SURGERY","authors":"Nalan SAYGI EMİR, Güneş Özlem YILDIZ","doi":"10.56766/ntms.1264292","DOIUrl":"https://doi.org/10.56766/ntms.1264292","url":null,"abstract":"Objective :Minimally invasive surgeries have important advantages such as lower morbidity, shorter hospital stay, and earlier return to routine life. Robot-assisted laparoscopic surgery (RALS) plays a leading role in the development process of minimally invasive surgery. In this study, we compared patients with endometrial cancer who were operated with RALS and traditional laparoscopic surgery (TLS) methods in terms of processes related to anesthesia, such as peroperative fluid management and transfusion requirement, analgesic strategies, postoperative complications, duration of post-anesthesia care unit (PACU) and hospital stay
 Materials and Methods: Patients with American Society of Anaesthesiologists (ASA) scores II-III, over the age of 18, who were operated for endometrial cancer by TLS or RALS methods between January 2020 and March 2022 were included in the study. Patients age, ASA score, duration of surgery, peroperative fluid management, transfusion requirement, urine output, bleeding, postoperative Visual Analogue Scale (VAS) scores, the PACU admission were obtained from the standard anesthesia record form and preoperative and postoperative hemoglobin (Hb) values, length of hospital stay were obtained from the electronic database of the hospital. 
 Results: Intravenous fluid input, bleeding and urine output during the operation were statistically lower in group RALS. While there was no difference between the preoperative Hb values of the two groups, the postoperative Hb values were significantly lower in the TLS group. Perioperative bleeding and fluid replacement are lesser and the hospital stay is shorter in RALS. 
 Conclusion: TLS and RALS, which are minimally invasive surgical methods, are used in the treatment of endometrial cancer. The idea that RALS is more costly than TLS should be reconsidered, as RALS reduces costs with less perioperative bleeding and fluid replacement and shorter hospital stay","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136129335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: Traffic accidents are among the most common causes of mortality due to trauma. This study aimed to examine demographic and clinical characteristics that may affect mortality among patients who were involved in traffic accidents inside and outside a vehicle.
Methods: In this retrospective study conducted with 2,120 patients, the patients were divided into two groups according to whether they had an in-vehicle or out-of-vehicle traffic accident. The patients in both groups were evaluated according to age, gender, personal characteristics, time of accident, Glasgow Coma Scale (GCS) scores, injury sites, and diagnoses. Then, factors that could be effective in mortality were compared between the two groups using statistical methods.
Results: The rate of patients who had had a non-vehicle traffic accident was 19.1% (p=0.001), and 13 patients in this group had a GCS score of 3 (p=0.000). The most common injury site was the head and neck region at a rate of 24.8% (p=0.000). Mortality occurred in 3.2% and 0.9% of the patients in the out-of-vehicle and in-vehicle accident groups, respectively (p=0.001).
Conclusion: Mortality was higher in out-of-vehicle traffic accidents than in in-vehicle traffic accidents. Mortality was also higher among patients with low GCS scores, regardless of whether an accident occurred inside or outside a vehicle.
{"title":"Evaluation of Mortality in Patients Involved In-vehicle and Out-of-vehicle Traffic Accidents","authors":"Fatma ÇAKMAK, Ali GÜR, Bahar KESKİN ÇELİK","doi":"10.56766/ntms.1309803","DOIUrl":"https://doi.org/10.56766/ntms.1309803","url":null,"abstract":"Aims: Traffic accidents are among the most common causes of mortality due to trauma. This study aimed to examine demographic and clinical characteristics that may affect mortality among patients who were involved in traffic accidents inside and outside a vehicle.
 Methods: In this retrospective study conducted with 2,120 patients, the patients were divided into two groups according to whether they had an in-vehicle or out-of-vehicle traffic accident. The patients in both groups were evaluated according to age, gender, personal characteristics, time of accident, Glasgow Coma Scale (GCS) scores, injury sites, and diagnoses. Then, factors that could be effective in mortality were compared between the two groups using statistical methods.
 Results: The rate of patients who had had a non-vehicle traffic accident was 19.1% (p=0.001), and 13 patients in this group had a GCS score of 3 (p=0.000). The most common injury site was the head and neck region at a rate of 24.8% (p=0.000). Mortality occurred in 3.2% and 0.9% of the patients in the out-of-vehicle and in-vehicle accident groups, respectively (p=0.001).
 Conclusion: Mortality was higher in out-of-vehicle traffic accidents than in in-vehicle traffic accidents. Mortality was also higher among patients with low GCS scores, regardless of whether an accident occurred inside or outside a vehicle.","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136129487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Infectious diseases can affect the myocardium directly or through cytokines. Disruption of cardiac depolarization and repolarization is associated with the development of arrhythmia. In this study, we aimed to evaluate electrocardiographic (ECG) parameters in patients with Crimean-Congo Hemorrhagic Fever (CCHF). 42 patients hospitalized with the diagnosis of CCHF were included in the study. Heart rate, PR interval, P dispersion, QRS duration, QT interval and corrected QT, T peak T end, Tp-e/QT ratio, Tp-e/QTc ratio, and QT dispersion parameters were calculated from 12-lead ECGs at the time of admission and discharge. The mean age of the patients in the study was 45.8 ± 16.9 years. ECG parameters were found to be similar at admission and discharge (all p values>0.1). Major events such as life-threatening bleeding, significant hypotension, and shock were not observed in any of the patients. Platelet and white blood cell values were significantly increased at discharge compared to admission (78.3 vs 197.6 x103, p=0.01 and 2.8 vs 5.4 x103, p=0.006 respectively). In patients with CCHF, there was no significant change in ECG polarization parameters at the onset of the active infection process and during hospitalization period and these parameters found to be within normal limits.
传染病可直接或通过细胞因子影响心肌。心脏去极化和复极化的中断与心律失常的发生有关。在这项研究中，我们旨在评估克里米亚-刚果出血热(CCHF)患者的心电图(ECG)参数。42例诊断为慢性心力衰竭的住院患者纳入研究。通过入院和出院时12导联心电图计算患者心率、PR间期、P离散度、QRS持续时间、QT间期及校正QT、T峰T端、Tp-e/QT比值、Tp-e/QTc比值、QT离散度参数。患者的平均年龄为45.8±16.9岁。入院和出院时心电图参数相似(p值均为0.1)。在所有患者中未观察到危及生命的出血、明显低血压和休克等重大事件。与入院时相比，出院时血小板和白细胞值显著增加(分别为78.3 vs 197.6 x103, p=0.01和2.8 vs 5.4 x103, p=0.006)。CCHF患者在感染初期和住院期间的心电图极化参数无明显变化，均在正常范围内。
{"title":"Electrocardiographic Evaluation of Patients with Crimean-Congo Hemorrhagic Fever","authors":"Emrah AKSAKAL, Sibel İBA YILMAZ, Handan ALAY, Oguzhan Ekrem TURAN, Mustafa ÖZTÜRK, Gökhan CEYHUN, Omer KARASAHİN","doi":"10.56766/ntms.1216237","DOIUrl":"https://doi.org/10.56766/ntms.1216237","url":null,"abstract":"Infectious diseases can affect the myocardium directly or through cytokines. Disruption of cardiac depolarization and repolarization is associated with the development of arrhythmia. In this study, we aimed to evaluate electrocardiographic (ECG) parameters in patients with Crimean-Congo Hemorrhagic Fever (CCHF). 42 patients hospitalized with the diagnosis of CCHF were included in the study. Heart rate, PR interval, P dispersion, QRS duration, QT interval and corrected QT, T peak T end, Tp-e/QT ratio, Tp-e/QTc ratio, and QT dispersion parameters were calculated from 12-lead ECGs at the time of admission and discharge. The mean age of the patients in the study was 45.8 ± 16.9 years. ECG parameters were found to be similar at admission and discharge (all p values>0.1). Major events such as life-threatening bleeding, significant hypotension, and shock were not observed in any of the patients. Platelet and white blood cell values were significantly increased at discharge compared to admission (78.3 vs 197.6 x103, p=0.01 and 2.8 vs 5.4 x103, p=0.006 respectively). In patients with CCHF, there was no significant change in ECG polarization parameters at the onset of the active infection process and during hospitalization period and these parameters found to be within normal limits.","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136129330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Selçuk YILMAZ, Hasan ŞİMŞEK, Sefa KÜÇÜKLER, Serpil AYGÖRMEZ, Ender ERDOĞAN, Fatih Mehmet KANDEMİR
Aim: Cancer is a disease that is on the rise worldwide. Paclitaxel (PTX) is one of the most common chemotherapeutic agents used in the treatment of many cancers. PTX causes toxic effects by increasing oxidative stress in tissues. Naringin is a powerful antioxidant found naturally in many plants, especially citrus fruits. The aim of this study was to determine the protective effects of NRG in PTX-induced sciatic nerve injury.
Methods: Thirty-five male rats were randomly divided into five groups: control, PTX, NRG, PTX+NRG-50, PTX+NRG-100. PTX was administered i.p. for the first five days and NRG 50 or 100 mg/kg orally on days 6-14. Sciatic nerve tissues were harvested and analyzed for markers of oxidative stress, inflammation and apoptosis damage levels by biochemical methods.
Results: PTX caused oxidative stress damage by increasing lipid peroxidation (MDA) and decreasing antioxidant capacity (SOD, CAT, GPx and GSH), inflammatory damage by increasing proinflammatory cytokine (NF-κB, TNF-α, IL-1β, SIRT1, TLR4, and NRF2) release, apoptotic damage by increasing apoptotic factor (Bax) and decreasing antiapoptotic factor (Bcl-2) in sciatic nerve tissue (p < 0.05). NRG, on the other hand, reversed all these changes in sciatic nerve tissue and reduced PTX-induced oxidative stress damage, inflammatory damage and apoptotic damage (p < 0.05). These effects were more effective at the 100 mg/kg dose of NRG than at the 50 mg/kg dose (p < 0.05).
Conclusions: In sciatic nerve tissue, PTX induced peripheral neuropathy with increased oxidative stress, inflammation and apoptotic damage. NRG showed a protective effect against PTX-induced peripheral neuropathy.
{"title":"Naringin is Protective in Paclitaxel-Induced Peripheral Neuropathy; A multi-biomarker approach","authors":"Selçuk YILMAZ, Hasan ŞİMŞEK, Sefa KÜÇÜKLER, Serpil AYGÖRMEZ, Ender ERDOĞAN, Fatih Mehmet KANDEMİR","doi":"10.56766/ntms.1325124","DOIUrl":"https://doi.org/10.56766/ntms.1325124","url":null,"abstract":"Aim: Cancer is a disease that is on the rise worldwide. Paclitaxel (PTX) is one of the most common chemotherapeutic agents used in the treatment of many cancers. PTX causes toxic effects by increasing oxidative stress in tissues. Naringin is a powerful antioxidant found naturally in many plants, especially citrus fruits. The aim of this study was to determine the protective effects of NRG in PTX-induced sciatic nerve injury.
 Methods: Thirty-five male rats were randomly divided into five groups: control, PTX, NRG, PTX+NRG-50, PTX+NRG-100. PTX was administered i.p. for the first five days and NRG 50 or 100 mg/kg orally on days 6-14. Sciatic nerve tissues were harvested and analyzed for markers of oxidative stress, inflammation and apoptosis damage levels by biochemical methods.
 Results: PTX caused oxidative stress damage by increasing lipid peroxidation (MDA) and decreasing antioxidant capacity (SOD, CAT, GPx and GSH), inflammatory damage by increasing proinflammatory cytokine (NF-κB, TNF-α, IL-1β, SIRT1, TLR4, and NRF2) release, apoptotic damage by increasing apoptotic factor (Bax) and decreasing antiapoptotic factor (Bcl-2) in sciatic nerve tissue (p < 0.05). NRG, on the other hand, reversed all these changes in sciatic nerve tissue and reduced PTX-induced oxidative stress damage, inflammatory damage and apoptotic damage (p < 0.05). These effects were more effective at the 100 mg/kg dose of NRG than at the 50 mg/kg dose (p < 0.05).
 Conclusions: In sciatic nerve tissue, PTX induced peripheral neuropathy with increased oxidative stress, inflammation and apoptotic damage. NRG showed a protective effect against PTX-induced peripheral neuropathy.","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136129485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: Immunization is the most effective and reliable protection method from infectious diseases in both children and adults. As the issue of adult immunization is not given enough emphasis, this research aims to evaluate the knowledge and attitudes concerning adult immunization of students in health-related fields at Erzincan Binali Yıldırım University, Turkey.
Methods: A descriptive cross-sectional study was conducted among all final-year students studying health at the Erzincan Binali Yıldırım University using a questionnaire including sociodemographic data as well as knowledge and attitudes about adult vaccination. The statistical data were analyzed by number and percentage using Statistical Package for the Social Sciences software, version 21.0.
Results: A total of 379 students took part in the study, and only 19% of the students reported having sufficient knowledge about adult immunization. It was observed that for the participants, among the vaccines administered in adulthood, the hepatitis B and the meningococcus vaccines were the most and least familiar, respectively. When asked about knowledge and attitudes concerning vaccines administered in adulthood, the respondents proved uninformed about many vaccination practices.
Conclusion: In this study, the students lacked sufficient knowledge and awareness on adult immunization; therefore, it is of great importance to educate students on immunization prior to their graduation to increase adult immunization rates in the general public.
目的:免疫接种是儿童和成人预防传染病最有效、最可靠的保护方法。由于成人免疫接种问题没有得到足够的重视，本研究旨在评估土耳其Erzincan Binali Yıldırım大学健康相关专业学生对成人免疫接种的知识和态度。
方法:对Erzincan Binali Yıldırım大学卫生专业的所有大四学生进行描述性横断面研究，使用问卷调查，包括社会人口统计数据以及成人疫苗接种的知识和态度。采用Social Sciences软件statistical Package for version 21.0对统计数据进行数字和百分比分析。& # x0D;结果:共有379名学生参加了研究，只有19%的学生报告对成人免疫有足够的了解。观察到，对于参与者来说，在成年期接种的疫苗中，乙型肝炎和脑膜炎球菌疫苗分别是最熟悉的和最不熟悉的。当被问及关于成人接种疫苗的知识和态度时，应答者证明对许多疫苗接种做法一无所知。结论:本研究中学生成人免疫接种知识和意识不足;因此，在毕业前对学生进行免疫教育，提高成人免疫接种率具有重要意义。
{"title":"Evaluation of knowledge and attitudes concerning adult immunization in university students enrolled in health-related departments: A cross-sectional study","authors":"Sara SALCAN, Duygu KAVUNCUOĞLU","doi":"10.56766/ntms.1283194","DOIUrl":"https://doi.org/10.56766/ntms.1283194","url":null,"abstract":"Aims: Immunization is the most effective and reliable protection method from infectious diseases in both children and adults. As the issue of adult immunization is not given enough emphasis, this research aims to evaluate the knowledge and attitudes concerning adult immunization of students in health-related fields at Erzincan Binali Yıldırım University, Turkey.
 Methods: A descriptive cross-sectional study was conducted among all final-year students studying health at the Erzincan Binali Yıldırım University using a questionnaire including sociodemographic data as well as knowledge and attitudes about adult vaccination. The statistical data were analyzed by number and percentage using Statistical Package for the Social Sciences software, version 21.0. 
 Results: A total of 379 students took part in the study, and only 19% of the students reported having sufficient knowledge about adult immunization. It was observed that for the participants, among the vaccines administered in adulthood, the hepatitis B and the meningococcus vaccines were the most and least familiar, respectively. When asked about knowledge and attitudes concerning vaccines administered in adulthood, the respondents proved uninformed about many vaccination practices.
 Conclusion: In this study, the students lacked sufficient knowledge and awareness on adult immunization; therefore, it is of great importance to educate students on immunization prior to their graduation to increase adult immunization rates in the general public.","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136129334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The role of infections in the etiopathogenesis of Behçet’s Disease has been mentioned, but there is no study in the literature on the frequency of Urinary Tract Infections in Behçet’s Disease.
Objective: The purpose of the present study was to investigate the frequency of Urinary Tract Infections and its relationship with disease severity in patients who had Behçet’s Disease.
Methods: The study had a retrospective cross-sectional design. A total of 113 Behçet’s Disease patients were included in the study. The files of the patients were reviewed and their symptoms as of the date of admission and the results of total urine analysis and urine culture performed in line with this date were recorded. The frequency of urinary system infections and its relationship with disease severity were examined.
Results: A total of 113 Behçet’s Disease patients who had a median age of 38 (IQR: 29 - 47) and 74.3% (n=84) women were evaluated in the present study. Urinary tract infection was defined in 8.8% (n=10) of the patients. Escherichia coli was identified as the causative microorganism in 90% (n=9) and Klebsiella spp. in 10% (n=1) of patients who had Urinary Tract Infections. Behçet’s Disease patients who had Urinary Tract Infections were older and Urinary Tract Infections were more common in those with longer disease duration (p=0.001 and p=0.005, respectively). No statistically significant relationship was detected between the severity of Behçet’s Disease and the presence of urinary system infections (p>0.05). Dysuria and pyuria were detected more frequently in Behçet’s Disease patients who had positive pathergy test results and no Urinary Tract Infections (p=0.007, p=0.038, respectively). Leukocyte esterase positivity was detected more frequently in Behçet’s Disease patients who did not have urinary infections but had genital ulcers (p=0.039).
Conclusion: Urinary system infection was detected in 8.8% (n=10) of Behçet’s Disease patients. Although no relationship was found between the severity of the disease and urinary system infection in the present study, we think that patients who have Urinary Tract Infections should be treated because there are infectious causes in the etiopathogenesis of Behçet’s Disease.
{"title":"Frequency of Urinary Tract Infection and its relationship with disease severity in patients with Behçet’s Disease","authors":"Erdal PALA, Omer KARASAHİN","doi":"10.56766/ntms.1293021","DOIUrl":"https://doi.org/10.56766/ntms.1293021","url":null,"abstract":"Background: The role of infections in the etiopathogenesis of Behçet’s Disease has been mentioned, but there is no study in the literature on the frequency of Urinary Tract Infections in Behçet’s Disease.
 Objective: The purpose of the present study was to investigate the frequency of Urinary Tract Infections and its relationship with disease severity in patients who had Behçet’s Disease.
 Methods: The study had a retrospective cross-sectional design. A total of 113 Behçet’s Disease patients were included in the study. The files of the patients were reviewed and their symptoms as of the date of admission and the results of total urine analysis and urine culture performed in line with this date were recorded. The frequency of urinary system infections and its relationship with disease severity were examined.
 Results: A total of 113 Behçet’s Disease patients who had a median age of 38 (IQR: 29 - 47) and 74.3% (n=84) women were evaluated in the present study. Urinary tract infection was defined in 8.8% (n=10) of the patients. Escherichia coli was identified as the causative microorganism in 90% (n=9) and Klebsiella spp. in 10% (n=1) of patients who had Urinary Tract Infections. Behçet’s Disease patients who had Urinary Tract Infections were older and Urinary Tract Infections were more common in those with longer disease duration (p=0.001 and p=0.005, respectively). No statistically significant relationship was detected between the severity of Behçet’s Disease and the presence of urinary system infections (p>0.05). Dysuria and pyuria were detected more frequently in Behçet’s Disease patients who had positive pathergy test results and no Urinary Tract Infections (p=0.007, p=0.038, respectively). Leukocyte esterase positivity was detected more frequently in Behçet’s Disease patients who did not have urinary infections but had genital ulcers (p=0.039).
 Conclusion: Urinary system infection was detected in 8.8% (n=10) of Behçet’s Disease patients. Although no relationship was found between the severity of the disease and urinary system infection in the present study, we think that patients who have Urinary Tract Infections should be treated because there are infectious causes in the etiopathogenesis of Behçet’s Disease.","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136129488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The oculomotor nerve root's medial aspect in the cisternal space is closely associated with the posterior communicating artery and receives blood supply from it. This study investigates whether ischemic damage to oculomotor nerve roots results from posterior communicating artery spasm in subarachnoid hemorrhages. Methods: A total of 18 rabbits participated in this study. Baseline pupil diameters were measured using sunlight and ocular tomography. Rabbits were divided into control (GI, n=5), SHAM (GII, n=5; 0.75 cc serum physiologic injection), and subarachnoid hemorrhage-induced groups (GIII, n=8; 0.75 cc autolog blood injection). Pupil diameters were re-measured after the experiment and daily for three weeks. The animals were observed for one week before euthanasia. The posterior communicating artery vasospasm index (VSI) was determined using the wall surface/lumen surface ratio. Stereological methods were employed to examine the normal and degenerated axon densities of the oculomotor nerves. The Kruskal-Wallis and Mann-Whitney U tests were used to evaluate degenerated axon density (n/mm2) and VSI values. A p-value of less than 0.005 was considered significant. Results: Degenerated axon numbers (n/mm2) and VSI values of the posterior communicating artery were as follows: 3±1/0.936±0.212 in GI; 18±4/1.578±0.235 in GII; and 212±34/2.515±0.347 in GIII. The p-values were p
{"title":"Predictive Role of Posterior Communicating Artery Spasm on Axonal Degeneration in Oculomotor Nerve Root Following Subarachnoid Hemorrhage: Experimental Study","authors":"M. Zeynal, M. Şahin","doi":"10.56766/ntms.1277530","DOIUrl":"https://doi.org/10.56766/ntms.1277530","url":null,"abstract":"Background: The oculomotor nerve root's medial aspect in the cisternal space is closely associated with the posterior communicating artery and receives blood supply from it. This study investigates whether ischemic damage to oculomotor nerve roots results from posterior communicating artery spasm in subarachnoid hemorrhages. \u0000Methods: A total of 18 rabbits participated in this study. Baseline pupil diameters were measured using sunlight and ocular tomography. Rabbits were divided into control (GI, n=5), SHAM (GII, n=5; 0.75 cc serum physiologic injection), and subarachnoid hemorrhage-induced groups (GIII, n=8; 0.75 cc autolog blood injection). Pupil diameters were re-measured after the experiment and daily for three weeks. The animals were observed for one week before euthanasia. The posterior communicating artery vasospasm index (VSI) was determined using the wall surface/lumen surface ratio. Stereological methods were employed to examine the normal and degenerated axon densities of the oculomotor nerves. The Kruskal-Wallis and Mann-Whitney U tests were used to evaluate degenerated axon density (n/mm2) and VSI values. A p-value of less than 0.005 was considered significant. \u0000Results: Degenerated axon numbers (n/mm2) and VSI values of the posterior communicating artery were as follows: 3±1/0.936±0.212 in GI; 18±4/1.578±0.235 in GII; and 212±34/2.515±0.347 in GIII. The p-values were p","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"110 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121604665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy. Early diagnosis and treatment are important; the condition can cause both maternal and foetal complications. Today, single-/double-bolus oral 50–100-g glucose tolerance tests (OGTTs) are preferred. We explored whether the peripheral blood platelet/lymphocyte ratio (PLR) and/or neutrophil/lymphocyte ratio (NLR) could guide diabetes screening of a target group (rather than all pregnant women). Materials and Methods: This retrospective study was conducted at the Obstetrics and Gynecology Clinic of Sanko University Hospital from January 2010 to January 2020. Pregnant women in gestational weeks 24 to 28 who underwent 75-g OGTTs were included. Patients were evaluated by dividing them into two groups. Group 1 included 300 women with GDM. Group 2 included 300 healthy pregnant women who were negative on the OGTT test. We retrieved patient ages, gestational weeks, all blood count data derived during pregnancy, fasting blood glucose levels, heights and weights, and body mass indices. Results: Leukocyte and neutrophil counts were significantly higher in the diabetic patient group than in the control group (both p < 0.01). The NLR and PLR differed significantly between the two groups (both p < 0.01), but the demographic data did not. Conclusion: Increase in white blood cell count, and elevations in the PLR and NLR, independently predicted GDM. Blood NLR and PLR can also be used as a GDM screening test. The NLR and PLR (markers of inflammation) were significantly increased in pre-diabetic and diabetic patients. The NLR and PLR may usefully predict pre-diabetes and GDM.
{"title":"The platelet/lymphocyte and neutrophil/lymphocyte ratios of pregnant women who underwent the 75-g oral glucose tolerance test to predict gestational diabetes","authors":"Y. Topdağı, Ç. Demiroğlu, A. Şahin","doi":"10.56766/ntms.1199230","DOIUrl":"https://doi.org/10.56766/ntms.1199230","url":null,"abstract":"Background: Gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy. Early diagnosis and treatment are important; the condition can cause both maternal and foetal complications. Today, single-/double-bolus oral 50–100-g glucose tolerance tests (OGTTs) are preferred. We explored whether the peripheral blood platelet/lymphocyte ratio (PLR) and/or neutrophil/lymphocyte ratio (NLR) could guide diabetes screening of a target group (rather than all pregnant women). \u0000Materials and Methods: This retrospective study was conducted at the Obstetrics and Gynecology Clinic of Sanko University Hospital from January 2010 to January 2020. Pregnant women in gestational weeks 24 to 28 who underwent 75-g OGTTs were included. Patients were evaluated by dividing them into two groups. Group 1 included 300 women with GDM. Group 2 included 300 healthy pregnant women who were negative on the OGTT test. We retrieved patient ages, gestational weeks, all blood count data derived during pregnancy, fasting blood glucose levels, heights and weights, and body mass indices. \u0000Results: Leukocyte and neutrophil counts were significantly higher in the diabetic patient group than in the control group (both p < 0.01). The NLR and PLR differed significantly between the two groups (both p < 0.01), but the demographic data did not. \u0000Conclusion: Increase in white blood cell count, and elevations in the PLR and NLR, independently predicted GDM. Blood NLR and PLR can also be used as a GDM screening test. The NLR and PLR (markers of inflammation) were significantly increased in pre-diabetic and diabetic patients. The NLR and PLR may usefully predict pre-diabetes and GDM.","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124219448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Although chemotherapy increases the survival rate of cancer patients, it causes significant side effects such as deterioration in cognitive functions that generate a decline in their living standards. In our study, the effect of adalimumab on anxiety- and depression-like behaviors in mice with cognitive impairment with methotrexate was investigated. In our study, methotrexate (40 mg kg-1) was administered intraperitoneally as a single dose to create a chemobrain model in mice. Adalimumab (10 mg kg-1), a TNF-alpha inhibitor, was administered twice, 1 hour and 5 days before methotrexate administration. Anxiety-like behaviors were measured with elevated plus maze test and open field test, depression-like behaviors were measured with tail suspension test, and hippocampal tissue was examined histopathologically. Methotrexate decreased the time spent in the central zone in the open-field arena, the time spent in the open arms in the elevated plus maze test, and increased the duration of immobility in the tail suspension test in rats. Methotrexate caused a decrease in the number of neuronal cells in the CA3 region of the hippocampus, as well as neurodegenerative and atrophic changes. Adalimumab ameliorated methotrexate-related anxiety- and depression-like behaviors, and caused improvement in histopathological changes. In this study, it was shown that methotrexate-related anxiety and depression-like behavioral disorders were prevented by adalimumab treatment, but further studies are recommended to investigate the mechanisms mediating the therapeutic effect of adalimumab.
{"title":"Effect of tnf-alpha inhibitor on anxiety- and depression-like behaviors in a mouse chemobrain model","authors":"M. Öz, N. Akaras","doi":"10.56766/ntms.1239435","DOIUrl":"https://doi.org/10.56766/ntms.1239435","url":null,"abstract":"Although chemotherapy increases the survival rate of cancer patients, it causes significant side effects such as deterioration in cognitive functions that generate a decline in their living standards. In our study, the effect of adalimumab on anxiety- and depression-like behaviors in mice with cognitive impairment with methotrexate was investigated. In our study, methotrexate (40 mg kg-1) was administered intraperitoneally as a single dose to create a chemobrain model in mice. Adalimumab (10 mg kg-1), a TNF-alpha inhibitor, was administered twice, 1 hour and 5 days before methotrexate administration. Anxiety-like behaviors were measured with elevated plus maze test and open field test, depression-like behaviors were measured with tail suspension test, and hippocampal tissue was examined histopathologically. Methotrexate decreased the time spent in the central zone in the open-field arena, the time spent in the open arms in the elevated plus maze test, and increased the duration of immobility in the tail suspension test in rats. Methotrexate caused a decrease in the number of neuronal cells in the CA3 region of the hippocampus, as well as neurodegenerative and atrophic changes. Adalimumab ameliorated methotrexate-related anxiety- and depression-like behaviors, and caused improvement in histopathological changes. In this study, it was shown that methotrexate-related anxiety and depression-like behavioral disorders were prevented by adalimumab treatment, but further studies are recommended to investigate the mechanisms mediating the therapeutic effect of adalimumab.","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132520559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aims: Intensive care professionals are the individuals who are most exposed to the psychological effects of the COVID-19 pandemic The aim of the present study was to evaluate and compare the, traumatic stress symptoms and health anxiety in intensive care unit (ICU) workers and non-ICU workers who have been playing an active role in caring for COVID-19 patients. Method: The sociodemographic characteristics of all the healthcare professionals working in the ICU and other units, were recorded. In addition, their history of COVID-19 infection, living with an elderly person, intensive care hospitalization history of relatives, and death status of relatives due to COVID-19 were recorded. The participants were divided into two groups, namely ICU workers and non-ICU workers. The Health Anxiety Inventory (HAI)and the Impact of Event Scale-Revised (IES-R) scales were applied to all the participants. Results: Of the 150 healthcare workers initially identified, 116 agreed to participate in this study. Sixty-nine (59.5%) of them were working in the ICU, while 47 (40.5%) were in non-ICU. The mean IES-R score of all participants was 40.19 ± 15.73. When the IES-R scores and ICU results with non-ICUs were compared, the healthcare workers who work in ICU had significantly higher total IES-R scores (42.83 ± 14.65, p
{"title":"TRAUMATIC STRESS AND HEALTH ANXIETY IN INTENSIVECARE WORKERS DURING THE COVID-19 PANDEMIC","authors":"Esra Demi̇ryürek, H. Kocayiğit","doi":"10.56766/ntms.1209313","DOIUrl":"https://doi.org/10.56766/ntms.1209313","url":null,"abstract":"Aims: Intensive care professionals are the individuals who are most exposed to the psychological effects of the COVID-19 pandemic \u0000The aim of the present study was to evaluate and compare the, traumatic stress symptoms and health anxiety in intensive care unit (ICU) workers and non-ICU workers who have been playing an active role in caring for COVID-19 patients. \u0000Method: The sociodemographic characteristics of all the healthcare professionals working in the ICU and other units, were recorded. In addition, their history of COVID-19 infection, living with an elderly person, intensive care hospitalization history of relatives, and death status of relatives due to COVID-19 were recorded. The participants were divided into two groups, namely ICU workers and non-ICU workers. The Health Anxiety Inventory (HAI)and the Impact of Event Scale-Revised (IES-R) scales were applied to all the participants. \u0000Results: Of the 150 healthcare workers initially identified, 116 agreed to participate in this study. Sixty-nine (59.5%) of them were working in the ICU, while 47 (40.5%) were in non-ICU. \u0000The mean IES-R score of all participants was 40.19 ± 15.73. When the IES-R scores and ICU results with non-ICUs were compared, the healthcare workers who work in ICU had significantly higher total IES-R scores (42.83 ± 14.65, p","PeriodicalId":371755,"journal":{"name":"New Trends in Medicine Sciences","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123882087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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