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Functional interplay between the Hippo pathway and heavy metals Hippo通路与重金属之间的功能相互作用
IF 2.1 Q3 ONCOLOGY
Molecular and Cellular Oncology
Pub Date : 2022-04-09 DOI: 10.1080/23723556.2022.2061297
Han Han, Alisa L. Mahieu, Lucas de Paula, Wenqi Wang
ABSTRACT Emerging studies highlight the Hippo pathway as an important player in organ size control, tissue homeostasis, regeneration, development, and diseases, but our understanding of its roles and regulations remains incomplete. Our recent work reported a functional interplay between the Hippo pathway and heavy metals, providing new insights into this key signaling pathway.
摘要：新兴的研究强调，Hippo通路在器官大小控制、组织稳态、再生、发育和疾病中发挥着重要作用，但我们对其作用和调节的理解仍然不完整。我们最近的工作报道了Hippo通路和重金属之间的功能相互作用，为这一关键信号通路提供了新的见解。
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引用次数: 0
RAD51 wrestles with SUMO RAD51与相扑摔跤
IF 2.1 Q3 ONCOLOGY
Molecular and Cellular Oncology
Pub Date : 2022-03-31 DOI: 10.1080/23723556.2022.2054263
Y. Kee, Jung-Hee Lee, H. You
ABSTRACT RAD51 loading onto chromatin is a key step during the homologous recombination (HR) repair. We recently reported a new mode of RAD51 regulation, which is mediated by TOPORS E3 SUMO ligase and RAD51 SUMOylation. ATM/ATR-induced phosphorylation of TOPORS is necessary for this event, revealing a new role of these master DNA damage response kinases in HR repair.
RAD51在染色质上的负载是同源重组（HR）修复过程中的关键步骤。我们最近报道了一种新的RAD51调节模式，该模式由TOPORS E3 SUMO连接酶和RAD51 SUMO化介导。ATM/ATR诱导的TOPORS磷酸化对于这一事件是必要的，揭示了这些主DNA损伤反应激酶在HR修复中的新作用。
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引用次数: 0
Biological effects of olive oil phenolic compounds on mitochondria 橄榄油酚类化合物对线粒体的生物学效应
IF 2.1 Q3 ONCOLOGY
Molecular and Cellular Oncology
Pub Date : 2022-03-20 DOI: 10.1080/23723556.2022.2044263
Mercedes Blanco-Benítez, Ana Calderón-Fernández, Saray Canales-Cortés, Eva Alegre-Cortés, E. Uribe-Carretero, Marta Paredes-Barquero, Alberto Giménez-Bejarano, Gema Duque González, P. Gomez-Suaga, J. Ortega-Vidal, S. Salido, J. Altarejos, G. Martínez-Chacón, M. Niso-Santano, J. M. Fuentes, R. González-Polo, S. M. Yakhine-Diop
ABSTRACT Phenolic compounds derived from olive oil have beneficial health properties against cancer, neurodegenerative, and metabolic diseases. Therefore, there are discrepancies in their impact on mitochondrial function that result in changes in oxidative capacity, mitochondrial respiration, and energetic demands. This review focuses on the versatile role of oleuropein, a potent antioxidant that regulates the AMPK/SIRT1/mTOR pathway to modulate autophagy/mitophagy and maintain metabolic homeostasis.
摘要：从橄榄油中提取的酚类化合物具有对抗癌症、神经退行性疾病和代谢性疾病的有益健康特性。因此，它们对线粒体功能的影响存在差异，导致氧化能力、线粒体呼吸和能量需求的变化。这篇综述的重点是油尿蛋白的多功能作用，油尿蛋白是一种强效抗氧化剂，可调节AMPK/SIRT1/mTOR通路，调节自噬/线粒体自噬并维持代谢稳态。
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引用次数: 6
Yta7, a chromatin segregase regulated by the cell cycle machinery Yta7，一种受细胞周期机制调节的染色质分离酶
IF 2.1 Q3 ONCOLOGY
Molecular and Cellular Oncology
Pub Date : 2022-03-17 DOI: 10.1080/23723556.2022.2039577
Priyanka Bansal, Christoph F. Kurat
ABSTRACT We have recently revealed the existence of a cell cycle-regulated chromatin segregase, Yta7 (Yeast Tat-binding Analog 7), involved in chromosome replication. Phosphorylation of Yta7 by S-CDK (S-phase Cyclin-Dependent Kinase) regulates its function. These findings link the cell cycle to chromatin biology and suggest how chromatin-modifying enzymes become S phase-specific.
我们最近发现了一种细胞周期调节的染色质分离酶Yta7(酵母tat结合类似物7)的存在，它参与了染色体复制。S-CDK (s期周期蛋白依赖激酶)磷酸化Yta7调控其功能。这些发现将细胞周期与染色质生物学联系起来，并提示染色质修饰酶如何成为S期特异性。
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引用次数: 2
Escape from senescence: revisiting cancer therapeutic strategies 逃离衰老：重新审视癌症治疗策略
IF 2.1 Q3 ONCOLOGY
Molecular and Cellular Oncology
Pub Date : 2022-02-15 DOI: 10.1080/23723556.2022.2030158
C. Zampetidis, A. Papantonis, V. Gorgoulis
ABSTRACT Although senescence has been considered as an irreversible cell arrest state, accumulating evidence challenge this view. Consequently, senescence appears as an imperfect barrier to impede cancer progression, constituting a step prior to disease relapse. Therefore, cancer treatment strategies may benefit if revisited to include senolytic agents.
虽然衰老被认为是一种不可逆的细胞停滞状态，但越来越多的证据挑战了这一观点。因此，衰老似乎是阻止癌症进展的不完美屏障，是疾病复发之前的一个步骤。因此，如果重新考虑包括抗衰老药物在内的癌症治疗策略，可能会受益。
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引用次数: 3
Rewired lipid metabolism as an actionable vulnerability of aggressive colorectal carcinoma 脂质代谢异常是侵袭性结直肠癌的一个可操作的弱点
IF 2.1 Q3 ONCOLOGY
Molecular and Cellular Oncology
Pub Date : 2022-01-27 DOI: 10.1080/23723556.2021.2024051
D. Capece, G. Franzoso
ABSTRACT Cancer cells reprogram lipid metabolism to fuel cell division, adaptation to stress, and metastatic dissemination. NF-κB transcription factors control this mechanism in aggressive Consensus Molecular Subtype (CMS)4 of colorectal carcinoma (CRC) via triacylglycerol (TAG) lipase, carboxylesterase 1 (CES1), thereby linking obesity-associated inflammation with metabolic adaptation and cytoprotection from lipid-induced toxicity. Our findings identify a potential therapeutic route to treat patients with metastasis-prone CRC and provide an example for targeting core tumor subtype-based vulnerabilities in cancers beyond CRC.
摘要癌症细胞重新编程脂质代谢以促进细胞分裂、适应压力和转移扩散。NF-κB转录因子通过三酰甘油（TAG）脂肪酶、羧酸酯酶1（CES1）在结直肠癌（CRC）侵袭性共有分子亚型（CMS）4中控制这一机制，从而将肥胖相关炎症与代谢适应和细胞保护作用联系起来，使其免受脂质诱导的毒性。我们的发现确定了一种治疗易转移CRC患者的潜在治疗途径，并为靶向CRC以外癌症中基于核心肿瘤亚型的脆弱性提供了一个例子。
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引用次数: 3
Barrett's esophagus stages: their correlation with SBS17-associated DNA mutations and the identification of histological marker genes Barrett食管分期与SBS17相关DNA突变的相关性及组织学标志基因的鉴定
IF 2.1 Q3 ONCOLOGY
Molecular and Cellular Oncology
Pub Date : 2022-01-22 DOI: 10.1080/23723556.2022.2026559
Georg A. Busslinger
ABSTRACT We have recently reported a correlation between the accumulation of specific T > C and T > G mutations and the chromosomal instability in cells of Barrett's esophagus (BE), which represents a premalignant condition of esophageal adenocarcinoma. Additionally, we identified seven marker genes that facilitate the distinction of individual BE stages by histopathological examination.
摘要：我们最近报道了特异性T>C和T>G突变的积累与巴雷特食管（BE）细胞中染色体不稳定之间的相关性，这代表了食管腺癌的癌前状态。此外，我们通过组织病理学检查鉴定了七个有助于区分个体BE分期的标记基因。
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引用次数: 0
Tumor suppressor pathways shape EGFR-driven lung tumor progression and response to treatment 肿瘤抑制途径影响EGFR驱动的肺部肿瘤进展和治疗反应
IF 2.1 Q3 ONCOLOGY
Molecular and Cellular Oncology
Pub Date : 2022-01-14 DOI: 10.1080/23723556.2021.1994328
G. Foggetti, Chuan Li, Hongchen Cai, D. Petrov, M. Winslow, K. Politi
ABSTRACT In vivo modeling combined with CRISPR/Cas9-mediated somatic genome editing has contributed to elucidating the functional importance of specific genetic alterations in human tumors. Our recent work uncovered tumor suppressor pathways that affect EGFR-driven lung tumor growth and sensitivity to tyrosine kinase inhibitors and reflect the mutational landscape and treatment outcomes in the human disease.
体内建模结合CRISPR/ cas9介导的体细胞基因组编辑有助于阐明人类肿瘤中特定遗传改变的功能重要性。我们最近的工作揭示了影响egfr驱动的肺肿瘤生长和对酪氨酸激酶抑制剂敏感性的肿瘤抑制通路，并反映了人类疾病的突变景观和治疗结果。
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引用次数: 0
Cell demise inhibited: Unexpected liaisons between mitochondria and IκΒα. 抑制细胞死亡：线粒体与 IκΒα 之间意想不到的联系。
IF 2.6 Q3 ONCOLOGY
Molecular and Cellular Oncology
Pub Date : 2022-01-11 eCollection Date: 2021-01-01 DOI: 10.4161/23723556.2014.995020
Evangelos Pazarentzos

IκΒα (the protein product of NFKBIA gene) has widely been considered a pro- apoptotic factor due to its ability to inhibit the anti-apoptotic transcription factor NFκB. Our findings indicate that IκΒα also exerts a strong anti-apoptotic activity at the outer mitochondria membrane (OMM). This function we uncovered is distinct from its ability to sequester and inhibit NFκB. IκΒα instead binds to voltage dependent anion channel 1 (VDAC1) and Hexokinase 2 (HK2), stabilizes this complex and prevents mitochondria outer membrane permeabilisation (MOMP) and apoptosis.

IκΒα（NFKBIA 基因的蛋白产物）由于能够抑制抗凋亡转录因子 NFκB 而被广泛认为是一种促凋亡因子。我们的研究结果表明，IκΒα 在线粒体外膜（OMM）上也具有很强的抗凋亡活性。我们发现的这一功能不同于它封存和抑制 NFκB 的能力。IκΒα 与电压依赖性阴离子通道 1（VDAC1）和六激酶 2（HK2）结合，稳定这一复合物并防止线粒体外膜渗透（MOMP）和细胞凋亡。
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引用次数: 0
APOBEC3 as a driver of genetic intratumor heterogeneity. APOBEC3作为肿瘤内遗传异质性的驱动因素
IF 2.1 Q3 ONCOLOGY
Molecular and Cellular Oncology
Pub Date : 2022-01-03 eCollection Date: 2023-01-01 DOI: 10.1080/23723556.2021.2014734
Subramanian Venkatesan, Mihaela Angelova, Jirina Bartkova, Samuel F Bakhoum, Jiri Bartek, Nnennaya Kanu, Charles Swanton

Our recent study revealed that APOBEC3B is upregulated during the preinvasive stages of non-small cell lung cancer and breast cancer. In addition to its role in mediating single nucleotide variants, we propose that APOBEC3 promotes copy number intratumor heterogeneity prior to invasion, providing a substrate for cancer evolution.

我们最近的研究表明，APOBEC3B在非小细胞肺癌和乳腺癌的侵袭前阶段上调。除了介导单核苷酸变异外，我们提出APOBEC3在侵袭前促进肿瘤内拷贝数的异质性，为癌症进化提供了一个底物。
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引用次数: 0
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