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Salivary biomarkers and burning mouth syndrome: a systematic review and meta-analysis of the literature 唾液生物标志物和灼口综合征:文献的系统回顾和荟萃分析
Q3 Dentistry Pub Date : 2023-01-01 DOI: 10.1051/mbcb/2023024
Florian Kappes, Samy Kerrad, Christelle Grémeau-Richard, L. Devoize
Introduction: Burning Mouth Syndrome (BMS) is defined by a burning sensation or intraoral dysesthesia without obvious causal lesion. Despite the development of research, diagnostic aids for this syndrome are non-existent and treatments are partially ineffective. Some studies have shown changes in salivary composition, viscosity or flow in patients with BMS. The evaluation of the salivary biochemical characteristics of patients with BMS could then help to better understand the pathogenesis of this disease. The objective of this meta-analysis is to perform a qualitative and quantitative synthesis of the literature concerning the salivary biomarkers present in patients with BMS in comparison to healthy subjects. Materials and methods: The PubMed, Web of Science and Cochrane databases were searched to identify articles corresponding to the defined inclusion criteria. Review Manager 5.4.1 software was used to perform the quantitative analysis. Results: The quantitative analysis included 15 articles and found a significant increase in salivary concentrations of cortisol and immunoglobulin A (IgA) with a standardized mean difference SMD = 0.53 and a 95% confidence interval CI [0.33 to 0.74] and SMD = 0.32 to 95% CI [0.10 to 0.55] respectively. For calcium and copper, the analysis found no significant difference in patients with BMS with SMD = 0.06 at 95% CI [–0.19 to 0.32] and SMD = -0.19 at 95% CI [–0.44 to 0.06]. Finally, for magnesium, the analysis found a probable decrease with SMD = -0.29 at 95% CI [–0.52 to -0.06]. Four other biomarkers (potassium, alpha amylase, zinc and total protein) showed too high levels of heterogeneity (I² > 44%) to be able to interpret the results with confidence. Discussion: This strong heterogeneity can be explained by different saliva sampling methods or biomarker measurement techniques that are not strictly identical between the studies. In addition, some saliva samples may have undergone blood contamination which may bias the results. Conclusion: This meta-analysis nevertheless confirms all the interest of focusing on salivary biomarkers in BMS patients; the measurement of cortisol and/or salivary IgA could be a line of research for the establishment of a standardized biological assessment. Nevertheless, the number of available studies being low and of variable methodological quality with a limited number of patients, additional studies are necessary to give a firm and definitive conclusion.
灼口综合征(BMS)的定义是无明显病因病变的烧灼感或口腔内感觉不良。尽管研究有所发展,但这种综合征的诊断辅助工具并不存在,治疗也部分无效。一些研究表明BMS患者的唾液成分、黏度或流量发生了变化。评价BMS患者的唾液生化特征有助于更好地了解这种疾病的发病机制。本荟萃分析的目的是对BMS患者与健康受试者的唾液生物标志物进行定性和定量综合。材料和方法:检索PubMed、Web of Science和Cochrane数据库,以确定符合定义的纳入标准的文章。采用Review Manager 5.4.1软件进行定量分析。结果:定量分析纳入15篇文章,发现唾液中皮质醇和免疫球蛋白a (IgA)浓度显著升高,标准化平均差SMD = 0.53, 95%可信区间CI[0.33 ~ 0.74]和SMD = 0.32 ~ 95% CI[0.10 ~ 0.55]。对于钙和铜,分析发现SMD = 0.06 (95% CI[-0.19至0.32])和SMD = -0.19 (95% CI[-0.44至0.06])的BMS患者无显著差异。最后,对于镁,分析发现SMD可能下降,95% CI[-0.52至-0.06]= -0.29。其他四种生物标志物(钾,α淀粉酶,锌和总蛋白)显示出过高的异质性水平(I²> 44%),无法自信地解释结果。讨论:这种强烈的异质性可以通过不同的唾液取样方法或生物标志物测量技术来解释,这些技术在研究之间并不完全相同。此外,一些唾液样本可能受到血液污染,这可能会影响结果。结论:该荟萃分析证实了关注BMS患者唾液生物标志物的所有兴趣;皮质醇和/或唾液IgA的测量可以作为建立标准化生物学评估的研究方向。然而,由于现有的研究数量较少,而且在有限的患者中,方法质量参差不齐,因此需要进行更多的研究才能得出坚定和明确的结论。
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引用次数: 0
Oral surgery and maxillofacial surgery: the logic of a single discipline 口腔外科与颌面外科:逻辑单一的学科
Q3 Dentistry Pub Date : 2023-01-01 DOI: 10.1051/mbcb/2023030
Joël Ferri
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引用次数: 0
Actinic cheilitis: guidance on monitoring and management in primary care 光化性舌炎:初级保健监测和管理指南
Q3 Dentistry Pub Date : 2023-01-01 DOI: 10.1051/mbcb/2023029
Preena Shah, Qingmei Feng, Barbara Carey, Marcio Diniz-Freitas, Jacobo Limeres, Luis Monteiro, Luis Silva, Jean-Cristophe Fricain, Sylvain Catros, Mathilde Fenelon, Niccolò Lombardi, Alberto Pispero, Giovanni Lodi, Vlaho Brailo, Danica Vidovi Juras, José López-López, Rui Albuquerque
Actinic cheilitis is an oral potentially malignant disorder caused by UV radiation leading to damage to epithelial keratinocytes of the lips. It predominantly affects the vermillion border of the lower lip. Due to its association with chronic UV exposure, associated risk factors include geographic areas, outdoor occupations, and skin subtypes. A high proportion of lip squamous cell carcinomas arise from actinic cheilitis lesions, with histological examination usually showing a degree of dysplasia. This paper aims to review the existing literature regarding the clinical picture of actinic cheilitis, its prevalence, differential diagnoses, and consensus on management, for the education of the general dental practitioner in identifying and surveillance of this lesion.
光化性唇炎是一种由紫外线辐射引起的口腔潜在恶性疾病,可导致唇部上皮角质形成细胞受损。它主要影响下唇的朱红色边界。由于其与慢性紫外线暴露有关,相关的危险因素包括地理区域、户外职业和皮肤亚型。很大比例的唇鳞状细胞癌是由光化性唇炎病变引起的,组织学检查通常显示一定程度的不典型增生。本文旨在回顾现有文献关于光化性口炎的临床表现,患病率,鉴别诊断和管理共识,以教育普通牙科医生识别和监测这种病变。
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引用次数: 0
A stroke mimicker following inferior alveolar nerve block: a case report 下肺泡神经阻滞后卒中模拟1例
Q3 Dentistry Pub Date : 2023-01-01 DOI: 10.1051/mbcb/2023021
Muhammad Kamil Hassan, Namkabir Singh, K. Selvaraju, W. Ngeow
Introduction: Local anesthesia administration albeit being the most common dental procedure is associated with complications that usually arise as a result of wrongly placed injections into local or distant sites. Here we present a case of an unexpected complication affecting the upper limb after dental anesthesia administration. Observation: A 26-year-old Malay female presented with the left upper extremity paralysis and paraesthesia following the administration of a local anesthesia block to the left inferior alveolar nerve, at a dental teaching center. The onset of the dental nerve block and left upper extremity weakness occurred and eventually subsided. As the provisional diagnosis was either a transient ischaemic attack or stroke, she was immediately referred to the Emergency Department. She was thoroughly assessed and monitored with the neurology team being consulted. Her vital signs remained stable and she showed no neurological deterioration throughout the observation period. She was discharged without further investigations after regaining full strength and sensation of her left upper extremity. The report tries to hypothesize the possible cause of this incident. Conclusion: This case highlights the importance of dentists being alert to possible effects of local anesthesia to regions beyond the head and neck area.
简介:局部麻醉虽然是最常见的牙科手术,但通常由于错误地将注射剂放置在局部或远处部位而引起并发症。在此,我们报告一个意外的并发症,影响上肢牙科麻醉后的情况。观察:一名26岁马来女性在牙科教学中心接受左下牙槽神经局部麻醉阻滞后,出现左上肢麻痹和感觉异常。发病时出现牙神经阻滞和左上肢无力,并最终消退。由于临时诊断是短暂性脑缺血发作或中风,她立即被转到急诊科。她接受了全面的评估和监测,并咨询了神经病学小组。患者生命体征稳定,观察期间未见神经功能恶化。患者在恢复左上肢完全力量和感觉后,未经进一步检查出院。报告试图对这一事件的可能原因作出假设。结论:本病例强调了牙医警惕局部麻醉对头颈部以外区域可能产生的影响的重要性。
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引用次数: 0
Multi-modal approach in management of vulvo-vaginal gingival syndrome − a rare variant of oral lichen planus 多模式入路治疗外阴-阴道龈综合征——一种罕见的口腔扁平苔藓
Q3 Dentistry Pub Date : 2023-01-01 DOI: 10.1051/mbcb/2023028
Shwetha V., Sujatha S., Rakesh N., Pavan T., Pooja Rathore
Lichen planus (LP) is a chronic autoimmune relapsing mucocutaneous disease that significantly affects the patient's quality of life (QoL) and is associated with several etiological factors. Vulvo-vaginal gingival syndrome (VVGS) is characterized as a clinical triad of gingival, vaginal and vulval LP. In previous literature, it has been described as a distinctive pattern of erosive plurimucosal LP. This condition if progressed can lead to multiple complications such as urethral and vaginal stenosis. This case report highlights the management of VVGS using a multidisciplinary strategy that includes dermatological consultation, oral hygiene maintenance, topical steroid application using custom-made trays and photodynamic therapy.
扁平苔藓(Lichen planus, LP)是一种慢性自身免疫性复发性粘膜皮肤病,严重影响患者的生活质量,并与多种病因相关。外阴-阴道牙龈综合征(VVGS)的临床特征是牙龈,阴道和外阴LP。在以前的文献中,它被描述为一种独特的糜烂性多粘膜LP。这种情况如果进展,可导致多种并发症,如尿道和阴道狭窄。本病例报告强调了使用多学科策略管理VVGS,包括皮肤病学咨询,口腔卫生维护,使用定制托盘的局部类固醇应用和光动力疗法。
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引用次数: 0
Fusion of primary maxillary incisors 上颌初级门牙融合
Q3 Dentistry Pub Date : 2023-01-01 DOI: 10.1051/mbcb/2023031
Mohamed Faizal Asan, Renita Lorina Castelino
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引用次数: 0
Clinical characteristics and management of odontogenic necrotizing fasciitis: a retrospective study 牙源性坏死性筋膜炎的临床特点及治疗:回顾性研究
Q3 Dentistry Pub Date : 2023-01-01 DOI: 10.1051/mbcb/2023027
Imen Mehri Turki
Background: Life-threatening illnesses like necrotizing fasciitis (NF) from dental origin arise suddenly and unexpectedly as a result of the debilitating condition and frequent self-medicating behaviour. This article aims to report the medical and therapeutic characteristics of 15 patients while discussing risk factors, pathogenetic mechanisms and management of this disease. Method: From 2012 up to 2022, a retrospective chart study of patients with odontogenic NF was carried out. Demographic, medical and therapeutic data were collected and analysed, using the Excel program. Results: Fifteen patients were identified with retrievable medical records. There was a male predominance, and the age ranged from 13 to 82 years with a majority over 40 years. Preadmission delay was ≤4 days in 40% of patients with self-medication of non-steroid anti-inflammatory drugs. 53.85% of patients had previous dental treatment without antibiotic coverage. Rheumatoid arthritis was the predominant comorbidity followed by diabetes mellitus and anaemia. Multispace involvement was found in 73.33% of patients. Preoperative computed tomography was performed for 60% of patients. Conclusion: Prompt and efficient treatment is required for NF, a polymicrobial odontogenic infection that is lethal even in healthy people. Self-medication and debilitating condition should be considered. Early diagnosis and therapy may reduce mortality and morbidity.
背景:牙齿源性坏死性筋膜炎(NF)等危及生命的疾病是由于身体虚弱和频繁的自我用药行为而突然和意外出现的。本文旨在报道15例患者的医学和治疗特点,并讨论本病的危险因素、发病机制和治疗。方法:对2012 ~ 2022年牙源性NF患者进行回顾性图表研究。使用Excel程序收集和分析人口统计、医疗和治疗数据。结果:15例患者有可检索的病历。男性居多,年龄13 ~ 82岁,40岁以上居多。40%自行使用非甾体类抗炎药的患者入院前延迟≤4天。53.85%的患者既往牙科治疗未覆盖抗生素。类风湿关节炎是主要的合并症,其次是糖尿病和贫血。73.33%的患者有多空间受累。60%的患者术前行计算机断层扫描。结论:NF是一种多微生物的牙源性感染,即使在健康人群中也是致命的,需要及时有效的治疗。应考虑自我用药和衰弱状况。早期诊断和治疗可降低死亡率和发病率。
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引用次数: 0
Does surgical removal of mandibular third molar influence the periodontal status of the adjacent second molars? A systematic review 手术切除下颌第三磨牙会影响相邻第二磨牙的牙周状况吗?系统回顾
Q3 Dentistry Pub Date : 2023-01-01 DOI: 10.1051/mbcb/2022032
Lélia Ménager, M. Ruperto, J. Fricain, S. Catros, M. Fénelon
Objective: This study aimed to assess the influence of mandibular third molar surgical removal on the periodontal status of adjacent second molars and to investigate the potential impact of the flap design. Methods: A systematic review of the literature, registered in PROSPERO, has been carried out from Pubmed and Scopus databases following PRISMA guidelines from January 2010 to January 2022. PICO method was used to select the relevant articles. Studies comparing the periodontal status of the second molar before and after mandibular third molar removal were considered. Results: Twenty-three studies involving 1067 patients were included. The two main parameters studied were periodontal pocket depth and clinical attachment level. The envelope flap and the triangular flap were the most commonly used flap techniques. Periodontal health of adjacent second molar was maintained or improved in most of the included studies. The flap design did not seem to have a significant influence either. Conclusion: Avulsion of impacted third molar in healthy young adults does not impair the periodontal health of adjacent second molars. Further studies, with higher levels of evidence, are needed to confirm these results and to identify possible risk factors (such as age, impaction depth or periodontal disease) responsible for poorer healing.
目的:探讨下颌第三磨牙手术切除对邻近第二磨牙牙周状况的影响,并探讨皮瓣设计的潜在影响。方法:根据2010年1月至2022年1月PRISMA指南,对在PROSPERO中注册的Pubmed和Scopus数据库中的文献进行系统综述。采用PICO方法选择相关文献。研究比较下颌第三磨牙拔除前后第二磨牙的牙周状况。结果:纳入23项研究,共1067例患者。研究的两个主要参数是牙周袋深度和临床附着水平。包络皮瓣和三角皮瓣是最常用的皮瓣技术。在大多数纳入的研究中,邻近第二磨牙的牙周健康得到了维持或改善。襟翼设计似乎也没有显著的影响。结论:健康青年阻生第三磨牙的撕脱不影响相邻第二磨牙的牙周健康。需要有更多证据的进一步研究来证实这些结果,并确定导致愈合不良的可能风险因素(如年龄、嵌塞深度或牙周病)。
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引用次数: 0
Reply to “A modified sagittal split osteotomy: description of technique” 回复“改良矢状面劈开截骨术:技术描述”
Q3 Dentistry Pub Date : 2023-01-01 DOI: 10.1051/mbcb/2023014
Dario Andrés Bastidas Castillo, Pamela Ramirez Naranjo
Dear Editor, We would like to thank you for your interest in our paper [1] and for bringing to our attention such important academic and scientific topics of discussion. In the first place, we want to clarify that at the moment the article was submitted, we did not acknowledge the article by Grimaud et al. “Vertical ramus elongation and mandibular advancement by endobuccal approach: Presentation of a new osteotomy technique” [2], because when we performed our literature search in 2020 using PubMed and Medline databases, the following strategies were used: “osteotomy ramus AND orthognathic surgery AND vertical ramus” and “MeSH Term (((“orthognathic surgery”[MeSH Terms]) AND (condyle, mandibular[MeSH Terms])) AND (osteotomy, sagittal split ramus[MeSH Terms])”, and said the article did not appear within the results. However, we now recognize that the article by Girmaud et al., and the article by T. Loncle “Modified technique used for sagittal splitting of the mandible” [3], present very similar techniques with quite the same clinical goals ad results in the treatment of Class II patients with severe loss of posterior facial height; a slight difference could be the fact that the presented cases for this technique were both done using the Wolfords protocol described in 2015 for inactive condylar resorption in Class II patients [4], that carries a simultaneous bilateral meniscopexy, since the loss of posterior facial height was attributed to the past condylar resorption. In addition, it needs to be stated that any kind of mandibular osteotomy design that included the gonial area in the distal fragment, could bear the same results such as the L-inverted osteotomy, the Epker-modified Wolford osteotomy and the Caldwell-Letterman technique, as you stated [5–7]; only, they face a greater restriction in the amount of mandibular advancement that can be achieved.
尊敬的编辑,我们非常感谢您对我们的论文[1]的兴趣,并让我们注意到如此重要的学术和科学话题的讨论。首先,我们要澄清的是,在文章提交时,我们并没有承认Grimaud等人的文章。“口腔内入路的垂直分支延伸和下颌推进:介绍一种新的截骨技术”[2],因为当我们在2020年使用PubMed和Medline数据库进行文献检索时,使用了以下策略:“截骨支和正颌外科以及垂直支”和“MeSH术语”((“正颌外科”[MeSH术语])和(髁突,下颌[MeSH术语]))和(截骨,矢状分裂支[MeSH术语]))”,并表示该文章没有出现在结果中。然而,我们现在认识到,Girmaud等人的文章和T. Loncle的文章“用于下颌矢状分裂的改良技术”[3]提出了非常相似的技术,具有完全相同的临床目标和结果,用于治疗II类患者严重的后面部高度损失;不同之处在于,采用该技术的病例均采用了2015年描述的针对II类患者[4]的非活动性髁骨吸收的Wolfords方案,该方案同时伴有双侧半月板脱位,因为后面部高度的下降归因于过去的髁骨吸收。此外,需要说明的是,如您所说的l-倒截骨术、epker改良的Wolford截骨术和Caldwell-Letterman技术,任何一种包括远端骨碎片的下颌骨截骨设计都可以获得相同的结果[5-7];只是,他们面临着更大的限制,在量下颌骨的进步,可以实现。
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引用次数: 0
Risk factors for early implant failure: a retrospective-multicentric study of 2323 implants in screw retained fixed full arch rehabilitation 早期种植体失败的危险因素:2323个螺钉固定全弓康复种植体的回顾性多中心研究
Q3 Dentistry Pub Date : 2023-01-01 DOI: 10.1051/mbcb/2023022
Matteo Di Lorenzo, Andrea Torsani, Paolo Tonveronachi, Samuele Baruch, Christian Caldari
Objectives: The aim of this retrospective study was to investigate possible risk factors for early implant failure in screw retained fixed full-arch rehabilitation. Methods: data of 487 patients (2323 implants) treated with full-arch rehabilitation supported by same implants brand were collected for the time period from 2017 to 2020 and examined to evaluate early implants failure rates. The following data were collected for statistical analysis: sex, age, health disorders (diabetes and hypertension) and bad habit (smoke) of the patient, location of the implant (maxilla or mandible, anterior or posterior site), type of implant's healing and bone regeneration procedures. Chi-squared test, bivariate comparison analysis and univariate mixed model analysis were used to estimate the effect of both patient-related and implant related variables on early implant failure as a potential risk factors. Results: 487 patients were included, 218 females (62.3 ± 9.14 of age) and 269 males (62.8 ± 10.11 of age) in 30 private institutions for a total of 2323 implants placed and a total of 526 screw retained fixed full arch rehabilitation. A total of 40 out of 2323 (1.7%) implants failed prematurely within 1 year, 32 in the maxilla 8 in the mandible. Bivariate comparison analysis and univariate mixed model analysis showed that female patient, implant placed in maxilla, age <61 years and submerged healed implants showed a statistically significant higher failure rate among the risk factors considered. Conclusions: Implants placed in the upper jaw and their modality of healing seems to be associated with a higher risk of early implant failure.
目的:本回顾性研究的目的是探讨螺钉固定全弓康复中早期种植体失败的可能危险因素。方法:收集2017 - 2020年487例患者(2323颗种植体)采用同一品牌种植体支持全弓康复治疗的数据,评估早期种植体失败率。收集以下数据进行统计分析:患者的性别、年龄、健康障碍(糖尿病、高血压)和不良习惯(吸烟)、种植体的位置(上颌骨或下颌骨、前位或后位)、种植体愈合类型和骨再生程序。采用卡方检验、双因素比较分析和单因素混合模型分析来评估患者相关变量和种植体相关变量对早期种植体失败的影响,作为潜在的危险因素。结果:共纳入30所私立机构487例患者,其中女性218例(62.3±9.14岁),男性269例(62.8±10.11岁),共放置种植体2323枚,固定全弓康复螺钉526枚。2323例种植体中有40例(1.7%)在1年内过早失败,其中32例在上颌骨,8例在下颌骨。双因素比较分析和单因素混合模型分析显示,女性患者、种植体放置于上颌、年龄<61岁、种植体愈合后浸入式种植体的失败率具有统计学意义。结论:种植体放置在上颌及其愈合方式似乎与早期种植体失败的高风险相关。
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引用次数: 1
期刊
Journal of Oral Medicine and Oral Surgery
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